locus-tag	class	description
HG15A2_00020	COG0592	DNA-directed DNA polymerase activity
HG15A2_00040	COG0187	DNA topoisomerase II activity
HG15A2_00080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_00110	COG0443	Heat shock 70 kDa protein
HG15A2_00190	COG2706	6-phosphogluconolactonase activity
HG15A2_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG15A2_00310	COG0440	acetolactate synthase activity
HG15A2_00320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG15A2_00360	COG0183	Belongs to the thiolase family
HG15A2_00440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_00470	COG1774	PSP1 C-terminal conserved region
HG15A2_00490	COG0563	adenylate kinase activity
HG15A2_00510	COG2366	antibiotic biosynthetic process
HG15A2_00520	COG0604	alcohol dehydrogenase
HG15A2_00530	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG15A2_00540	COG2900	Belongs to the SlyX family
HG15A2_00570	COG1335	isochorismatase
HG15A2_00580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_00580	COG5549	protein import
HG15A2_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_00630	COG3485	protocatechuate 3,4-dioxygenase
HG15A2_00700	COG0493	'glutamate synthase
HG15A2_00730	COG0067	glutamate synthase
HG15A2_00730	COG0069	glutamate synthase activity
HG15A2_00730	COG0070	glutamate synthase
HG15A2_00740	COG0583	DNA-binding transcription factor activity
HG15A2_00750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_00760	COG0742	ribosomal rna small subunit methyltransferase
HG15A2_00770	COG0657	acetylesterase activity
HG15A2_00770	COG2755	lipolytic protein G-D-S-L family
HG15A2_00780	COG0488	(ABC) transporter
HG15A2_00790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG15A2_00800	COG1408	metallophosphoesterase
HG15A2_00900	COG1132	(ABC) transporter
HG15A2_00920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_00940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_00950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG15A2_00970	COG0515	serine threonine protein kinase
HG15A2_01000	COG3119	arylsulfatase activity
HG15A2_01020	COG4662	Binding-protein-dependent transport system inner membrane component
HG15A2_01040	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
HG15A2_01050	COG1229	Formylmethanofuran dehydrogenase subunit A
HG15A2_01070	COG0746	molybdenum cofactor guanylyltransferase activity
HG15A2_01090	COG0303	'Molybdopterin
HG15A2_01270	COG0463	Glycosyl transferase, family 2
HG15A2_01270	COG1216	Glycosyl transferase, family 2
HG15A2_01330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_01360	COG2208	phosphoserine phosphatase activity
HG15A2_01390	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HG15A2_01410	COG2193	ferroxidase activity
HG15A2_01420	COG0702	epimerase
HG15A2_01460	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_01480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG15A2_01500	COG3046	protein related to deoxyribodipyrimidine photolyase
HG15A2_01520	COG2208	phosphoserine phosphatase activity
HG15A2_01550	COG2204	response regulator
HG15A2_01600	COG2304	oxidoreductase activity
HG15A2_01610	COG2304	oxidoreductase activity
HG15A2_01640	COG0714	Associated with various cellular activities
HG15A2_01710	COG0673	inositol 2-dehydrogenase activity
HG15A2_01830	COG0673	inositol 2-dehydrogenase activity
HG15A2_02020	COG4464	protein tyrosine phosphatase activity
HG15A2_02030	COG0489	protein tyrosine kinase activity
HG15A2_02030	COG3206	protein involved in exopolysaccharide biosynthesis
HG15A2_02090	COG1086	Polysaccharide biosynthesis protein
HG15A2_02130	COG0438	transferase activity, transferring glycosyl groups
HG15A2_02140	COG0438	transferase activity, transferring glycosyl groups
HG15A2_02180	COG0438	transferase activity, transferring glycosyl groups
HG15A2_02190	COG0726	polysaccharide deacetylase
HG15A2_02220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_02240	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_02260	COG0110	maltose O-acetyltransferase activity
HG15A2_02270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_02360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG15A2_02370	COG0724	RNA recognition motif
HG15A2_02380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG15A2_02410	COG0114	fumarate hydratase activity
HG15A2_02540	COG1733	regulation of RNA biosynthetic process
HG15A2_02550	COG1335	isochorismatase
HG15A2_02600	COG4974	Belongs to the 'phage' integrase family
HG15A2_02850	COG2815	serine threonine protein kinase
HG15A2_02850	COG0515	serine threonine protein kinase
HG15A2_02890	COG2146	nitrite reductase [NAD(P)H] activity
HG15A2_02890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG15A2_02900	COG0243	molybdopterin cofactor binding
HG15A2_02910	COG0437	4 iron, 4 sulfur cluster binding
HG15A2_02920	COG2223	nitrite transmembrane transporter activity
HG15A2_02940	COG1119	ATPase activity
HG15A2_03000	COG1196	nuclear chromosome segregation
HG15A2_03130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_03140	COG1136	(ABC) transporter
HG15A2_03340	COG0515	serine threonine protein kinase
HG15A2_03340	COG2815	serine threonine protein kinase
HG15A2_03620	COG3119	arylsulfatase activity
HG15A2_03660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG15A2_03730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG15A2_03740	COG3608	succinylglutamate desuccinylase aspartoacylase
HG15A2_03740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HG15A2_03780	COG3059	membrane
HG15A2_03840	COG1053	succinate dehydrogenase
HG15A2_03850	COG2009	succinate dehydrogenase
HG15A2_03870	COG5433	transposase activity
HG15A2_03920	COG0793	Belongs to the peptidase S41A family
HG15A2_03930	COG0138	bifunctional purine biosynthesis protein purh
HG15A2_03990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG15A2_04000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_04000	COG1776	CheC inhibitor of MCP methylation
HG15A2_04110	COG0590	tRNA wobble adenosine to inosine editing
HG15A2_04120	COG1088	dTDP-glucose 4,6-dehydratase activity
HG15A2_04140	COG2815	serine threonine protein kinase
HG15A2_04140	COG0515	serine threonine protein kinase
HG15A2_04210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG15A2_04390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG15A2_04420	COG0673	inositol 2-dehydrogenase activity
HG15A2_04740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG15A2_04800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG15A2_04800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG15A2_04810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG15A2_04850	COG0714	Associated with various cellular activities
HG15A2_04980	COG5002	protein histidine kinase activity
HG15A2_04990	COG0745	RESPONSE REGULATOR receiver
HG15A2_05030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HG15A2_05050	COG1070	Carbohydrate kinase
HG15A2_05060	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_05060	COG3347	Dehydrogenase
HG15A2_05070	COG1349	DNA-binding transcription factor activity
HG15A2_05100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG15A2_05110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG15A2_05120	COG0750	zinc metalloprotease
HG15A2_05130	COG0303	'Molybdopterin
HG15A2_05140	COG0512	Glutamine amidotransferase of anthranilate synthase
HG15A2_05150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG15A2_05190	COG1695	Transcriptional regulator
HG15A2_05220	COG0071	Belongs to the small heat shock protein (HSP20) family
HG15A2_05230	COG0456	acetyltransferase
HG15A2_05260	COG0545	Peptidyl-prolyl cis-trans isomerase
HG15A2_05280	COG2165	general secretion pathway protein
HG15A2_05300	COG0175	sulfate reduction
HG15A2_05310	COG0529	Catalyzes the synthesis of activated sulfate
HG15A2_05310	COG2895	sulfate adenylyltransferase (ATP) activity
HG15A2_05350	COG1959	2 iron, 2 sulfur cluster binding
HG15A2_05360	COG0175	sulfate reduction
HG15A2_05380	COG2855	membrane
HG15A2_05420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG15A2_05420	COG1017	nitric oxide dioxygenase activity
HG15A2_05440	COG1331	Highly conserved protein containing a thioredoxin domain
HG15A2_05460	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HG15A2_05480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG15A2_05510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG15A2_05550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_05650	COG0587	DNA-directed DNA polymerase activity
HG15A2_05660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_05730	COG2318	DinB family
HG15A2_05800	COG2081	HI0933 family
HG15A2_05820	COG1230	cation diffusion facilitator family transporter
HG15A2_05880	COG0463	Glycosyl transferase, family 2
HG15A2_05930	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG15A2_05940	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG15A2_05940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG15A2_05980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG15A2_05980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG15A2_06000	COG2084	Dehydrogenase
HG15A2_06050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG15A2_06060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG15A2_06070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG15A2_06080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG15A2_06130	COG1205	dead DEAH box helicase
HG15A2_06130	COG1111	helicase
HG15A2_06180	COG0205	6-phosphofructokinase activity
HG15A2_06190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_06210	COG0513	Belongs to the DEAD box helicase family
HG15A2_06280	COG2755	lipolytic protein G-D-S-L family
HG15A2_06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG15A2_06310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG15A2_06350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG15A2_06360	COG1216	Glycosyl transferase, family 2
HG15A2_06420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_06430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_06490	COG4956	integral membrane protein (PIN domain superfamily)
HG15A2_06500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HG15A2_06550	COG0738	Major facilitator superfamily
HG15A2_06560	COG0110	maltose O-acetyltransferase activity
HG15A2_06570	COG0300	oxidoreductase activity
HG15A2_06600	COG1137	ATPase activity
HG15A2_06610	COG0681	Belongs to the peptidase S26 family
HG15A2_06620	COG0681	Belongs to the peptidase S26 family
HG15A2_06670	COG0481	GTPase activity
HG15A2_06680	COG1940	carbohydrate kinase activity
HG15A2_06700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG15A2_06710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG15A2_06730	COG2274	protein secretion by the type I secretion system
HG15A2_06760	COG1131	(ABC) transporter
HG15A2_06770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_06800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG15A2_06810	COG0459	protein refolding
HG15A2_06820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_06830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG15A2_06830	COG0539	negative regulation of cytoplasmic translation
HG15A2_06870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG15A2_06890	COG0799	negative regulation of ribosome biogenesis
HG15A2_06900	COG0018	arginyl-trna synthetase
HG15A2_06930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG15A2_06950	COG1271	oxidase subunit
HG15A2_06990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG15A2_07000	COG2088	sporulation resulting in formation of a cellular spore
HG15A2_07010	COG4864	UPF0365 protein
HG15A2_07020	COG4864	UPF0365 protein
HG15A2_07030	COG0482	sulfurtransferase activity
HG15A2_07040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HG15A2_07090	COG0515	serine threonine protein kinase
HG15A2_07090	COG2815	serine threonine protein kinase
HG15A2_07120	COG0668	transmembrane transport
HG15A2_07140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG15A2_07150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG15A2_07160	COG0406	alpha-ribazole phosphatase activity
HG15A2_07170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG15A2_07220	COG0463	Glycosyl transferase, family 2
HG15A2_07250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG15A2_07260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG15A2_07270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG15A2_07300	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
HG15A2_07330	COG0515	serine threonine protein kinase
HG15A2_07330	COG2815	serine threonine protein kinase
HG15A2_07380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG15A2_07430	COG0686	Belongs to the AlaDH PNT family
HG15A2_07450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG15A2_07460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG15A2_07500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG15A2_07540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG15A2_07560	COG0673	inositol 2-dehydrogenase activity
HG15A2_07600	COG0673	inositol 2-dehydrogenase activity
HG15A2_07630	COG1301	dicarboxylic acid transport
HG15A2_07660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HG15A2_07690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HG15A2_07750	COG0740	serine-type endopeptidase activity
HG15A2_07760	COG0740	serine-type endopeptidase activity
HG15A2_07770	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG15A2_07840	COG0859	PFAM glycosyl transferase family 9
HG15A2_07850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HG15A2_07860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG15A2_07870	COG0297	glycogen (starch) synthase activity
HG15A2_07890	COG0438	transferase activity, transferring glycosyl groups
HG15A2_07920	COG4221	oxidoreductase activity
HG15A2_07960	COG0473	3-isopropylmalate dehydrogenase activity
HG15A2_07970	COG1022	Amp-dependent synthetase and ligase
HG15A2_07980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG15A2_08040	COG0577	efflux transmembrane transporter activity
HG15A2_08040	COG1136	(ABC) transporter
HG15A2_08100	COG1136	(ABC) transporter
HG15A2_08270	COG2095	MarC family integral membrane protein
HG15A2_08290	COG3119	arylsulfatase activity
HG15A2_08390	COG0285	dihydrofolate synthase activity
HG15A2_08430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG15A2_08480	COG1397	ADP-ribosylglycohydrolase
HG15A2_08500	COG1671	Belongs to the UPF0178 family
HG15A2_08540	COG0432	Pfam Uncharacterised protein family UPF0047
HG15A2_08560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_08620	COG0012	GTP binding
HG15A2_08640	COG1324	tolerance protein
HG15A2_08650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG15A2_08700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG15A2_08840	COG0438	transferase activity, transferring glycosyl groups
HG15A2_08880	COG1030	water channel activity
HG15A2_08890	COG1030	water channel activity
HG15A2_08900	COG0515	serine threonine protein kinase
HG15A2_08900	COG0457	Tetratricopeptide repeat
HG15A2_08920	COG4864	UPF0365 protein
HG15A2_08980	COG1785	Belongs to the alkaline phosphatase family
HG15A2_09000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG15A2_09000	COG1793	dna ligase
HG15A2_09040	COG0072	phenylalanine-tRNA ligase activity
HG15A2_09050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG15A2_09060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG15A2_09070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG15A2_09080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG15A2_09090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG15A2_09160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG15A2_09220	COG1162	GTPase activity
HG15A2_09330	COG0515	serine threonine protein kinase
HG15A2_09330	COG2815	serine threonine protein kinase
HG15A2_09480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_09570	COG3328	transposase activity
HG15A2_09600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG15A2_09750	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HG15A2_09760	COG0189	ligase activity
HG15A2_09770	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_09780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_09790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG15A2_09810	COG1858	cytochrome C peroxidase
HG15A2_09830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG15A2_09840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG15A2_09880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG15A2_09890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG15A2_09900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG15A2_09910	COG0596	Alpha beta hydrolase
HG15A2_09940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_09970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG15A2_10000	COG1573	uracil-dna glycosylase
HG15A2_10010	COG1160	GTP binding
HG15A2_10040	COG0395	ABC-type sugar transport system, permease component
HG15A2_10060	COG1175	transmembrane transport
HG15A2_10100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG15A2_10110	COG0463	Glycosyl transferase, family 2
HG15A2_10250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_10260	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG15A2_10300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG15A2_10320	COG0140	phosphoribosyl-ATP diphosphatase activity
HG15A2_10330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG15A2_10340	COG0142	geranyltranstransferase activity
HG15A2_10410	COG1278	Cold shock
HG15A2_10420	COG2197	response regulator
HG15A2_10440	COG1196	nuclear chromosome segregation
HG15A2_10480	COG0594	ribonuclease P activity
HG15A2_10530	COG3119	arylsulfatase activity
HG15A2_10640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG15A2_10670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG15A2_10680	COG0495	leucyl-tRNA aminoacylation
HG15A2_10700	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HG15A2_10710	COG0527	aspartate kinase activity
HG15A2_10740	COG2268	Band 7 protein
HG15A2_10770	COG0525	valine-tRNA ligase activity
HG15A2_10780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG15A2_10810	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_10850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG15A2_10860	COG0357	Ribosomal RNA small subunit methyltransferase G
HG15A2_10910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_10920	COG0514	ATP-dependent DNA helicase (RecQ)
HG15A2_10940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG15A2_10940	COG0574	Belongs to the PEP-utilizing enzyme family
HG15A2_11020	COG0483	inositol monophosphate 1-phosphatase activity
HG15A2_11030	COG0052	Belongs to the universal ribosomal protein uS2 family
HG15A2_11040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG15A2_11050	COG0528	UMP kinase activity
HG15A2_11060	COG0233	cytoplasmic translational termination
HG15A2_11090	COG0436	Aminotransferase
HG15A2_11100	COG1725	Transcriptional regulator
HG15A2_11110	COG1131	(ABC) transporter
HG15A2_11130	COG0505	Belongs to the CarA family
HG15A2_11150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG15A2_11160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG15A2_11170	COG0575	Belongs to the CDS family
HG15A2_11200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG15A2_11230	COG0443	Heat shock 70 kDa protein
HG15A2_11250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG15A2_11300	COG1966	Carbon starvation protein
HG15A2_11330	COG0017	Asparaginyl-tRNA synthetase
HG15A2_11500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG15A2_11510	COG4166	transmembrane transport
HG15A2_11520	COG0601	transmembrane transport
HG15A2_11530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG15A2_11550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG15A2_11580	COG0616	signal peptide processing
HG15A2_11590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG15A2_11600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG15A2_11620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_11640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG15A2_11650	COG1477	protein flavinylation
HG15A2_11660	COG0586	Pfam SNARE associated Golgi protein
HG15A2_11720	COG0126	phosphoglycerate kinase activity
HG15A2_11750	COG0354	folic acid binding
HG15A2_11840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HG15A2_11850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG15A2_11910	COG0205	6-phosphofructokinase activity
HG15A2_11930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG15A2_11940	COG1295	ribonuclease BN
HG15A2_11950	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_11990	COG2259	Doxx family
HG15A2_12010	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG15A2_12020	COG0069	glutamate synthase activity
HG15A2_12040	COG0326	Molecular chaperone. Has ATPase activity
HG15A2_12090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_12110	COG0135	phosphoribosylanthranilate isomerase activity
HG15A2_12120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG15A2_12130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG15A2_12170	COG1192	Involved in chromosome partitioning
HG15A2_12180	COG1475	DNA binding
HG15A2_12220	COG3119	arylsulfatase activity
HG15A2_12230	COG0714	Associated with various cellular activities
HG15A2_12260	COG2304	oxidoreductase activity
HG15A2_12270	COG2304	oxidoreductase activity
HG15A2_12300	COG3119	arylsulfatase activity
HG15A2_12350	COG0426	domain, Protein
HG15A2_12350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG15A2_12380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG15A2_12390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG15A2_12410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_12420	COG0471	metal ion transport
HG15A2_12420	COG3273	potassium ion transport
HG15A2_12440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG15A2_12450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG15A2_12460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG15A2_12470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG15A2_12480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG15A2_12490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG15A2_12500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG15A2_12510	COG0193	aminoacyl-tRNA hydrolase activity
HG15A2_12520	COG0360	Binds together with S18 to 16S ribosomal RNA
HG15A2_12530	COG0629	single-stranded DNA binding
HG15A2_12540	COG0359	binds to the 23S rRNA
HG15A2_12550	COG0305	Participates in initiation and elongation during chromosome replication
HG15A2_12570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG15A2_12580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_12590	COG0539	negative regulation of cytoplasmic translation
HG15A2_12590	COG2183	response to ionizing radiation
HG15A2_12610	COG1943	Transposase
HG15A2_12630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG15A2_12690	COG2363	Small membrane protein
HG15A2_12700	COG2379	hydroxypyruvate reductase
HG15A2_12780	COG0438	transferase activity, transferring glycosyl groups
HG15A2_12830	COG1215	transferase activity, transferring glycosyl groups
HG15A2_12860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG15A2_12900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_12920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_12930	COG1459	type II secretion system
HG15A2_13000	COG3118	belongs to the thioredoxin family
HG15A2_13050	COG4974	Belongs to the 'phage' integrase family
HG15A2_13080	COG2204	response regulator
HG15A2_13090	COG1620	l-lactate permease
HG15A2_13170	COG1968	undecaprenyl-diphosphatase activity
HG15A2_13220	COG0784	Response regulator, receiver
HG15A2_13230	COG4251	negative regulation of phosphorylation
HG15A2_13450	COG2204	response regulator
HG15A2_13470	COG3693	PFAM glycoside hydrolase, family 10
HG15A2_13480	COG3264	Mechanosensitive ion channel
HG15A2_13480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HG15A2_13490	COG3119	arylsulfatase activity
HG15A2_13500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG15A2_13520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG15A2_13540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG15A2_13550	COG1595	DNA-templated transcription, initiation
HG15A2_13590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG15A2_13600	COG0322	excinuclease ABC activity
HG15A2_13620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_13650	COG0504	CTP synthase activity
HG15A2_13660	COG0792	nuclease activity
HG15A2_13670	COG0335	large ribosomal subunit rRNA binding
HG15A2_13680	COG0336	Belongs to the RNA methyltransferase TrmD family
HG15A2_13690	COG0228	four-way junction DNA binding
HG15A2_13720	COG2852	Protein conserved in bacteria
HG15A2_13740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG15A2_13840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG15A2_13850	COG4591	ABC-type transport system involved in lipoprotein release permease component
HG15A2_13860	COG1136	(ABC) transporter
HG15A2_13890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG15A2_13890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG15A2_13900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG15A2_13980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG15A2_13990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG15A2_14110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG15A2_14260	COG3119	arylsulfatase activity
HG15A2_14270	COG3119	arylsulfatase activity
HG15A2_14360	COG3119	arylsulfatase activity
HG15A2_14760	COG1070	Carbohydrate kinase
HG15A2_14780	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_14800	COG1349	DNA-binding transcription factor activity
HG15A2_14810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_14840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG15A2_14870	COG2188	Transcriptional regulator
HG15A2_14910	COG1136	(ABC) transporter
HG15A2_14920	COG0577	efflux transmembrane transporter activity
HG15A2_14920	COG1136	(ABC) transporter
HG15A2_14940	COG0640	Transcriptional regulator
HG15A2_14950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_14960	COG0798	PFAM Bile acid sodium symporter
HG15A2_15020	COG1297	OPT oligopeptide transporter protein
HG15A2_15240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG15A2_15250	COG1757	Na H antiporter
HG15A2_15260	COG1619	proteins homologs of microcin C7 resistance protein MccF
HG15A2_15270	COG0405	Gamma-glutamyltransferase
HG15A2_15280	COG1757	Na H antiporter
HG15A2_15290	COG1686	Belongs to the peptidase S11 family
HG15A2_15300	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_15370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HG15A2_15380	COG2971	BadF BadG BcrA BcrD
HG15A2_15390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HG15A2_15410	COG3876	Protein conserved in bacteria
HG15A2_15550	COG3250	beta-galactosidase activity
HG15A2_15550	COG5297	Belongs to the glycosyl hydrolase family 6
HG15A2_15580	COG1649	PFAM Uncharacterised BCR, COG1649
HG15A2_15590	COG2807	transmembrane transport
HG15A2_15610	COG1472	Belongs to the glycosyl hydrolase 3 family
HG15A2_15750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HG15A2_15790	COG2205	protein histidine kinase activity
HG15A2_15820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_15840	COG1040	competence protein
HG15A2_15860	COG0181	hydroxymethylbilane synthase activity
HG15A2_15870	COG4786	Flagellar basal body rod
HG15A2_15880	COG4786	Flagellar basal body rod
HG15A2_15900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG15A2_15910	COG1706	bacterial-type flagellum-dependent cell motility
HG15A2_15940	COG4786	Flagellar basal body rod
HG15A2_15940	COG1256	bacterial-type flagellum assembly
HG15A2_15950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG15A2_15960	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HG15A2_15970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_16020	COG1473	amidohydrolase
HG15A2_16030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HG15A2_16050	COG3118	belongs to the thioredoxin family
HG15A2_16100	COG3842	ATPase activity
HG15A2_16130	COG2165	general secretion pathway protein
HG15A2_16210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_16230	COG0673	inositol 2-dehydrogenase activity
HG15A2_16250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HG15A2_16260	COG0470	DNA polymerase III
HG15A2_16280	COG2205	protein histidine kinase activity
HG15A2_16290	COG0047	phosphoribosylformylglycinamidine synthase activity
HG15A2_16310	COG0287	Prephenate dehydrogenase
HG15A2_16390	COG1217	gtp-binding protein TYPA
HG15A2_16410	COG1408	metallophosphoesterase
HG15A2_16450	COG0714	Associated with various cellular activities
HG15A2_16480	COG0009	L-threonylcarbamoyladenylate synthase
HG15A2_16490	COG0698	ribose 5-phosphate isomerase
HG15A2_16500	COG0515	serine threonine protein kinase
HG15A2_16500	COG2815	serine threonine protein kinase
HG15A2_16530	COG1131	(ABC) transporter
HG15A2_16560	COG0569	domain protein
HG15A2_16620	COG1074	ATP-dependent DNA helicase activity
HG15A2_16630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HG15A2_16690	COG4401	Chorismate mutase type I
HG15A2_16730	COG1760	l-serine dehydratase
HG15A2_16750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG15A2_16760	COG0598	Magnesium transport protein CorA
HG15A2_16770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG15A2_16780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_16860	COG0515	serine threonine protein kinase
HG15A2_16860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG15A2_16880	COG2723	6-phospho-beta-galactosidase activity
HG15A2_17080	COG0515	serine threonine protein kinase
HG15A2_17080	COG2815	serine threonine protein kinase
HG15A2_17090	COG0538	isocitrate dehydrogenase activity
HG15A2_17130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_17140	COG5002	protein histidine kinase activity
HG15A2_17170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HG15A2_17180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_17190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HG15A2_17240	COG1254	Belongs to the acylphosphatase family
HG15A2_17280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG15A2_17300	COG1253	flavin adenine dinucleotide binding
HG15A2_17320	COG1070	Carbohydrate kinase
HG15A2_17330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_17340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_17350	COG1233	COG1233 Phytoene dehydrogenase and related
HG15A2_17360	COG2304	oxidoreductase activity
HG15A2_17410	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG15A2_17550	COG0811	peptide transport
HG15A2_17620	COG3119	arylsulfatase activity
HG15A2_17690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_17700	COG3119	arylsulfatase activity
HG15A2_17720	COG2814	Major facilitator Superfamily
HG15A2_17750	COG3119	arylsulfatase activity
HG15A2_17760	COG3119	arylsulfatase activity
HG15A2_17780	COG0800	Aldolase
HG15A2_17800	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_17810	COG1802	Transcriptional regulator
HG15A2_17840	COG3119	arylsulfatase activity
HG15A2_17850	COG3119	arylsulfatase activity
HG15A2_17910	COG0515	serine threonine protein kinase
HG15A2_17910	COG2815	serine threonine protein kinase
HG15A2_17940	COG0134	indole-3-glycerol-phosphate synthase activity
HG15A2_17980	COG2204	response regulator
HG15A2_18010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_18070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG15A2_18080	COG2815	serine threonine protein kinase
HG15A2_18080	COG0515	serine threonine protein kinase
HG15A2_18100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG15A2_18120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG15A2_18130	COG0693	protein deglycase activity
HG15A2_18140	COG0824	Thioesterase
HG15A2_18190	COG0328	RNA-DNA hybrid ribonuclease activity
HG15A2_18200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG15A2_18230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG15A2_18230	COG1754	DNA topoisomerase type I activity
HG15A2_18250	COG0736	holo-[acyl-carrier-protein] synthase activity
HG15A2_18260	COG0180	Tryptophanyl-tRNA synthetase
HG15A2_18320	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG15A2_18330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG15A2_18340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG15A2_18350	COG0314	molybdopterin synthase activity
HG15A2_18360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG15A2_18370	COG0277	FAD linked oxidase domain protein
HG15A2_18400	COG0302	gtp cyclohydrolase
HG15A2_18430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG15A2_18440	COG0717	Belongs to the dCTP deaminase family
HG15A2_18450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG15A2_18450	COG0475	glutathione-regulated potassium exporter activity
HG15A2_18470	COG0788	formyltetrahydrofolate deformylase activity
HG15A2_18490	COG0116	Belongs to the methyltransferase superfamily
HG15A2_18490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG15A2_18510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG15A2_18510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG15A2_18520	COG1058	Belongs to the CinA family
HG15A2_18520	COG1546	Belongs to the CinA family
HG15A2_18550	COG0626	cystathionine gamma-synthase activity
HG15A2_18590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_18600	COG0358	DNA primase activity
HG15A2_18610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_18630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG15A2_18750	COG4970	Tfp pilus assembly protein FimT
HG15A2_18780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_18790	COG0590	tRNA wobble adenosine to inosine editing
HG15A2_18830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HG15A2_18850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG15A2_18860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG15A2_18880	COG2342	PFAM TM1410 hypothetical-related protein
HG15A2_18960	COG0514	ATP-dependent DNA helicase (RecQ)
HG15A2_18970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG15A2_18990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG15A2_19050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_19060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG15A2_19080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG15A2_19100	COG1459	type II secretion system
HG15A2_19130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HG15A2_19160	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG15A2_19170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HG15A2_19230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG15A2_19260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG15A2_19270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG15A2_19280	COG0673	inositol 2-dehydrogenase activity
HG15A2_19390	COG1560	Kdo2-lipid A biosynthetic process
HG15A2_19410	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_19420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_19450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_19480	COG2766	serine protein kinase
HG15A2_19490	COG2718	Belongs to the UPF0229 family
HG15A2_19500	COG2719	SpoVR family
HG15A2_19530	COG3253	May function as heme-dependent peroxidase
HG15A2_19540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG15A2_19550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG15A2_19570	COG0295	cytidine deaminase activity
HG15A2_19620	COG1090	epimerase
HG15A2_19690	COG0673	inositol 2-dehydrogenase activity
HG15A2_19700	COG0745	RESPONSE REGULATOR receiver
HG15A2_19840	COG1242	4 iron, 4 sulfur cluster binding
HG15A2_19870	COG1162	GTPase activity
HG15A2_19880	COG1196	nuclear chromosome segregation
HG15A2_19880	COG3264	Mechanosensitive ion channel
HG15A2_19890	COG1363	Peptidase, m42
HG15A2_19920	COG0084	hydrolase, TatD family'
HG15A2_19940	COG1007	ATP synthesis coupled electron transport
HG15A2_19960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG15A2_19970	COG0713	ATP synthesis coupled electron transport
HG15A2_19980	COG0839	Belongs to the complex I subunit 6 family
HG15A2_19990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG15A2_20000	COG0649	NAD binding
HG15A2_20010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_20020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_20040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_20060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG15A2_20080	COG0667	Aldo Keto reductase
HG15A2_20110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HG15A2_20190	COG0517	IMP dehydrogenase activity
HG15A2_20190	COG0617	tRNA 3'-terminal CCA addition
HG15A2_20190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_20220	COG1960	acyl-CoA dehydrogenase activity
HG15A2_20230	COG0667	Aldo Keto reductase
HG15A2_20250	COG0113	porphobilinogen synthase activity
HG15A2_20260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG15A2_20320	COG3344	reverse transcriptase
HG15A2_20340	COG0204	Acyl-transferase
HG15A2_20340	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_20400	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HG15A2_20410	COG1388	LysM domain
HG15A2_20410	COG0791	NLP P60 protein
HG15A2_20450	COG0515	serine threonine protein kinase
HG15A2_20450	COG2815	serine threonine protein kinase
HG15A2_20460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG15A2_20470	COG1214	PFAM Peptidase M22, glycoprotease
HG15A2_20490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_20490	COG0706	membrane insertase activity
HG15A2_20500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_20540	COG3119	arylsulfatase activity
HG15A2_20540	COG3408	Glycogen debranching enzyme
HG15A2_20560	COG2815	serine threonine protein kinase
HG15A2_20560	COG0515	serine threonine protein kinase
HG15A2_20780	COG0437	4 iron, 4 sulfur cluster binding
HG15A2_20850	COG4372	Transposase
HG15A2_20940	COG3119	arylsulfatase activity
HG15A2_20950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_20960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_21040	COG3119	arylsulfatase activity
HG15A2_21050	COG3119	arylsulfatase activity
HG15A2_21080	COG3119	arylsulfatase activity
HG15A2_21100	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_21110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_21130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_21140	COG2124	cytochrome p450
HG15A2_21160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_21190	COG2963	transposase activity
HG15A2_21210	COG5433	transposase activity
HG15A2_21260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG15A2_21280	COG0670	Belongs to the BI1 family
HG15A2_21350	COG1609	Transcriptional regulator
HG15A2_21350	COG2207	Transcriptional regulator
HG15A2_21360	COG0673	inositol 2-dehydrogenase activity
HG15A2_21420	COG4372	Transposase
HG15A2_21470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_21590	COG4106	trans-aconitate 2-methyltransferase activity
HG15A2_21750	COG0542	response to heat
HG15A2_21790	COG0443	Heat shock 70 kDa protein
HG15A2_21820	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG15A2_21830	COG0149	triose-phosphate isomerase activity
HG15A2_21850	COG1561	YicC-like family, N-terminal region
HG15A2_21860	COG0194	GDP metabolic process
HG15A2_21870	COG1758	RNA polymerase activity
HG15A2_21880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG15A2_21890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG15A2_21910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HG15A2_21920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG15A2_21990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG15A2_22000	COG4232	protein-disulfide reductase activity
HG15A2_22050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HG15A2_22070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG15A2_22080	COG0484	heat shock protein binding
HG15A2_22090	COG0459	protein refolding
HG15A2_22100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_22110	COG0459	protein refolding
HG15A2_22130	COG2770	Histidine kinase
HG15A2_22130	COG3437	response regulator, receiver
HG15A2_22170	COG4717	serine-type aminopeptidase activity
HG15A2_22190	COG0463	Glycosyl transferase, family 2
HG15A2_22210	COG0564	pseudouridine synthase activity
HG15A2_22220	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_22230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG15A2_22280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HG15A2_22310	COG5002	protein histidine kinase activity
HG15A2_22330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_22340	COG1459	type II secretion system
HG15A2_22430	COG0606	chelatase, subunit chli
HG15A2_22470	COG0564	pseudouridine synthase activity
HG15A2_22480	COG1970	mechanosensitive ion channel activity
HG15A2_22490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG15A2_22500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG15A2_22510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG15A2_22540	COG2211	Major facilitator Superfamily
HG15A2_22560	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG15A2_22600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG15A2_22630	COG4565	transcriptional regulatory protein
HG15A2_22700	COG0275	rRNA processing
HG15A2_22720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG15A2_22740	COG0316	Belongs to the HesB IscA family
HG15A2_22750	COG1104	cysteine desulfurase activity
HG15A2_22760	COG4112	unkown
HG15A2_22770	COG2373	Large extracellular alpha-helical protein
HG15A2_22780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_22800	COG3706	GGDEF domain
HG15A2_22810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_22870	COG1216	Glycosyl transferase, family 2
HG15A2_22880	COG0297	glycogen (starch) synthase activity
HG15A2_22890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_22900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HG15A2_22910	COG1442	glycosyl transferase family 8
HG15A2_22910	COG1216	Glycosyl transferase, family 2
HG15A2_22920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_22930	COG0673	inositol 2-dehydrogenase activity
HG15A2_23000	COG1477	protein flavinylation
HG15A2_23020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_23030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_23050	COG1805	sodium ion transport
HG15A2_23060	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_23070	COG0045	succinate-CoA ligase (ADP-forming) activity
HG15A2_23080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG15A2_23170	COG0202	RNA polymerase activity
HG15A2_23190	COG1796	DNA polymerase
HG15A2_23190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HG15A2_23220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG15A2_23320	COG1918	ferrous iron import across plasma membrane
HG15A2_23320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG15A2_23460	COG4245	von Willebrand factor, type A
HG15A2_23480	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HG15A2_23530	COG5433	transposase activity
HG15A2_23540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_23550	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_23580	COG1233	COG1233 Phytoene dehydrogenase and related
HG15A2_23590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_23610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG15A2_23690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_23810	COG3328	transposase activity
HG15A2_23850	COG2755	lipolytic protein G-D-S-L family
HG15A2_23900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_23940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_23960	COG0673	inositol 2-dehydrogenase activity
HG15A2_23990	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_24000	COG0673	inositol 2-dehydrogenase activity
HG15A2_24030	COG3328	transposase activity
HG15A2_24110	COG3119	arylsulfatase activity
HG15A2_24120	COG0673	inositol 2-dehydrogenase activity
HG15A2_24210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_24220	COG2942	2-epimerase
HG15A2_24280	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_24290	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_24300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_24360	COG2801	Transposase and inactivated derivatives
HG15A2_24400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_24460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_24470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HG15A2_24490	COG2239	Acts as a magnesium transporter
HG15A2_24500	COG0571	ribonuclease III activity
HG15A2_24520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_24530	COG2208	phosphoserine phosphatase activity
HG15A2_24610	COG3119	arylsulfatase activity
HG15A2_24740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_24750	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HG15A2_24760	COG1609	Transcriptional regulator
HG15A2_24850	COG3119	arylsulfatase activity
HG15A2_25010	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HG15A2_25030	COG0714	Associated with various cellular activities
HG15A2_25060	COG1690	Belongs to the RtcB family
HG15A2_25080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG15A2_25100	COG1056	cytidyltransferase-related domain
HG15A2_25100	COG1051	belongs to the nudix hydrolase family
HG15A2_25110	COG1397	ADP-ribosylglycohydrolase
HG15A2_25130	COG1335	isochorismatase
HG15A2_25170	COG0494	nUDIX hydrolase
HG15A2_25190	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HG15A2_25210	COG3541	Predicted nucleotidyltransferase
HG15A2_25580	COG0430	RNA-3'-phosphate cyclase activity
HG15A2_25620	COG4650	regulator
HG15A2_25710	COG2132	Multicopper oxidase
HG15A2_25730	COG1937	Protein conserved in bacteria
HG15A2_25770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_25920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_25950	COG1522	sequence-specific DNA binding
HG15A2_25960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_25970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG15A2_25990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_26050	COG5433	transposase activity
HG15A2_26140	COG2207	Transcriptional regulator
HG15A2_26140	COG1609	Transcriptional regulator
HG15A2_26200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_26250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_26260	COG3328	transposase activity
HG15A2_26290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG15A2_26330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG15A2_26430	COG0515	serine threonine protein kinase
HG15A2_26430	COG2815	serine threonine protein kinase
HG15A2_26590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG15A2_26610	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_26640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_26640	COG0617	tRNA 3'-terminal CCA addition
HG15A2_26640	COG0517	IMP dehydrogenase activity
HG15A2_26730	COG2165	general secretion pathway protein
HG15A2_26760	COG2204	response regulator
HG15A2_26770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_26780	COG1459	type II secretion system
HG15A2_26800	COG2165	general secretion pathway protein
HG15A2_26940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG15A2_26970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG15A2_27030	COG1131	(ABC) transporter
HG15A2_27070	COG0612	Peptidase, M16
HG15A2_27080	COG0612	Peptidase, M16
HG15A2_27120	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG15A2_27130	COG1121	(ABC) transporter
HG15A2_27140	COG1321	iron dependent repressor
HG15A2_27140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG15A2_27150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG15A2_27180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HG15A2_27190	COG0105	UTP biosynthetic process
HG15A2_27220	COG1278	Cold shock
HG15A2_27290	COG2151	metal-sulfur cluster biosynthetic enzyme
HG15A2_27310	COG0719	Fe-S assembly protein
HG15A2_27320	COG0719	Fe-S assembly protein
HG15A2_27330	COG0396	ATPase activity
HG15A2_27340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_27360	COG1115	amino acid carrier protein
HG15A2_27390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG15A2_27420	COG2815	serine threonine protein kinase
HG15A2_27420	COG0515	serine threonine protein kinase
HG15A2_27430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_27450	COG0673	inositol 2-dehydrogenase activity
HG15A2_27460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_27470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_27560	COG0714	Associated with various cellular activities
HG15A2_27600	COG0776	regulation of translation
HG15A2_27620	COG2815	serine threonine protein kinase
HG15A2_27620	COG0515	serine threonine protein kinase
HG15A2_27720	COG2801	Transposase and inactivated derivatives
HG15A2_27820	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_27850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG15A2_27860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG15A2_27880	COG2204	response regulator
HG15A2_27910	COG0628	permease
HG15A2_27930	COG3237	CsbD-like
HG15A2_28020	COG3685	Protein conserved in bacteria
HG15A2_28030	COG3237	CsbD-like
HG15A2_28050	COG0628	permease
HG15A2_28090	COG0693	protein deglycase activity
HG15A2_28120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_28120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG15A2_28160	COG4999	Histidine kinase
HG15A2_28160	COG2205	protein histidine kinase activity
HG15A2_28160	COG3437	response regulator, receiver
HG15A2_28160	COG3850	Histidine kinase
HG15A2_28180	COG4372	Transposase
HG15A2_28230	COG0811	peptide transport
HG15A2_28240	COG0848	biopolymer transport protein
HG15A2_28250	COG0848	biopolymer transport protein
HG15A2_28290	COG2815	serine threonine protein kinase
HG15A2_28290	COG0515	serine threonine protein kinase
HG15A2_28310	COG0564	pseudouridine synthase activity
HG15A2_28330	COG0673	inositol 2-dehydrogenase activity
HG15A2_28350	COG1272	protein, Hemolysin III
HG15A2_28370	COG0402	S-adenosylhomocysteine deaminase activity
HG15A2_28380	COG1668	transmembrane transport
HG15A2_28390	COG4555	ABC transporter
HG15A2_28400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG15A2_28430	COG4152	abc transporter atp-binding protein
HG15A2_28470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG15A2_28500	COG0243	molybdopterin cofactor binding
HG15A2_28510	COG0653	protein targeting
HG15A2_28550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG15A2_28630	COG0438	transferase activity, transferring glycosyl groups
HG15A2_28650	COG4589	Belongs to the CDS family
HG15A2_28700	COG0475	glutathione-regulated potassium exporter activity
HG15A2_28700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG15A2_28720	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HG15A2_28770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG15A2_28820	COG4191	Histidine kinase
HG15A2_28830	COG2204	response regulator
HG15A2_28850	COG0247	lactate metabolic process
HG15A2_28860	COG0277	FAD linked oxidase domain protein
HG15A2_28870	COG0277	FAD linked oxidase domain protein
HG15A2_28910	COG2801	Transposase and inactivated derivatives
HG15A2_28920	COG3344	reverse transcriptase
HG15A2_29090	COG5433	transposase activity
HG15A2_29140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_29160	COG3237	CsbD-like
HG15A2_29170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG15A2_29200	COG0438	transferase activity, transferring glycosyl groups
HG15A2_29280	COG5433	transposase activity
HG15A2_29400	COG0515	serine threonine protein kinase
HG15A2_29400	COG2815	serine threonine protein kinase
HG15A2_29430	COG0714	Associated with various cellular activities
HG15A2_29520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_29530	COG0537	adenosine 5'-monophosphoramidase activity
HG15A2_29680	COG3119	arylsulfatase activity
HG15A2_29690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG15A2_29730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG15A2_29760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG15A2_29890	COG1333	cytochrome c biogenesis protein
HG15A2_29890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG15A2_29950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG15A2_29960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG15A2_29970	COG0154	amidase activity
HG15A2_29980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG15A2_30000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG15A2_30040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG15A2_30060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG15A2_30070	COG0552	protein localization to endoplasmic reticulum
HG15A2_30080	COG0004	ammonium transporteR
HG15A2_30110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG15A2_30120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG15A2_30130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG15A2_30140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG15A2_30150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG15A2_30160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG15A2_30180	COG0356	it plays a direct role in the translocation of protons across the membrane
HG15A2_30220	COG1606	tRNA processing
HG15A2_30330	COG2755	lipolytic protein G-D-S-L family
HG15A2_30350	COG0515	serine threonine protein kinase
HG15A2_30370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HG15A2_30430	COG3706	GGDEF domain
HG15A2_30430	COG4251	negative regulation of phosphorylation
HG15A2_30430	COG5001	Diguanylate cyclase
HG15A2_30430	COG2203	Gaf domain
HG15A2_30480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG15A2_30500	COG3706	GGDEF domain
HG15A2_30510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_30540	COG0473	3-isopropylmalate dehydrogenase activity
HG15A2_30570	COG2326	polyphosphate kinase activity
HG15A2_30580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HG15A2_30610	COG1678	Uncharacterized ACR, COG1678
HG15A2_30640	COG1904	glucuronate isomerase
HG15A2_30700	COG0534	Mate efflux family protein
HG15A2_30730	COG0556	nucleotide-excision repair
HG15A2_30790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_30850	COG0471	metal ion transport
HG15A2_30940	COG1609	Transcriptional regulator
HG15A2_31010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG15A2_31110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HG15A2_31140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG15A2_31180	COG0066	3-isopropylmalate dehydratase activity
HG15A2_31190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG15A2_31200	COG0515	serine threonine protein kinase
HG15A2_31200	COG2815	serine threonine protein kinase
HG15A2_31220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_31230	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HG15A2_31240	COG0393	Putative heavy-metal-binding
HG15A2_31250	COG0393	Putative heavy-metal-binding
HG15A2_31280	COG1404	Belongs to the peptidase S8 family
HG15A2_31290	COG3958	Transketolase
HG15A2_31300	COG3959	Transketolase, thiamine diphosphate binding domain
HG15A2_31310	COG0667	Aldo Keto reductase
HG15A2_31320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_31420	COG3206	protein involved in exopolysaccharide biosynthesis
HG15A2_31420	COG0489	protein tyrosine kinase activity
HG15A2_31440	COG1086	Polysaccharide biosynthesis protein
HG15A2_31460	COG0477	Major facilitator Superfamily
HG15A2_31460	COG2814	Major facilitator Superfamily
HG15A2_31520	COG4464	protein tyrosine phosphatase activity
HG15A2_31530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_31550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG15A2_31570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_31630	COG2197	response regulator
HG15A2_31640	COG0464	growth
HG15A2_31670	COG5487	UPF0391 membrane protein
HG15A2_31700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HG15A2_31770	COG0457	Tetratricopeptide repeat
HG15A2_31770	COG0515	serine threonine protein kinase
HG15A2_31810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG15A2_31830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG15A2_31840	COG2010	Cytochrome c
HG15A2_31850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HG15A2_31890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG15A2_31900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG15A2_31930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG15A2_31980	COG0006	proline dipeptidase activity
HG15A2_31990	COG0511	ligase activity, forming carbon-carbon bonds
HG15A2_32000	COG0439	Biotin carboxylase
HG15A2_32010	COG0205	6-phosphofructokinase activity
HG15A2_32020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG15A2_32040	COG0131	Imidazoleglycerol-phosphate dehydratase
HG15A2_32060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG15A2_32070	COG0307	riboflavin synthase, alpha
HG15A2_32090	COG0688	phosphatidylethanolamine metabolic process
HG15A2_32100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG15A2_32110	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_32130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG15A2_32160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG15A2_32270	COG1132	(ABC) transporter
HG15A2_32280	COG3119	arylsulfatase activity
HG15A2_32380	COG2211	Major facilitator Superfamily
HG15A2_32420	COG1136	(ABC) transporter
HG15A2_32420	COG0577	efflux transmembrane transporter activity
HG15A2_32450	COG4191	Histidine kinase
HG15A2_32470	COG0577	efflux transmembrane transporter activity
HG15A2_32470	COG1136	(ABC) transporter
HG15A2_32490	COG0277	FAD linked oxidase domain protein
HG15A2_32490	COG0247	lactate metabolic process
HG15A2_32530	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_32560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG15A2_32590	COG0811	peptide transport
HG15A2_32720	COG5433	transposase activity
HG15A2_32910	COG2207	Transcriptional regulator
HG15A2_32910	COG1609	Transcriptional regulator
HG15A2_32980	COG0673	inositol 2-dehydrogenase activity
HG15A2_33070	COG2801	Transposase and inactivated derivatives
HG15A2_33140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG15A2_33170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HG15A2_33180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG15A2_33190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG15A2_33220	COG2244	polysaccharide biosynthetic process
HG15A2_33270	COG1216	Glycosyl transferase, family 2
HG15A2_33290	COG0493	'glutamate synthase
HG15A2_33300	COG0535	radical SAM domain protein
HG15A2_33310	COG1505	serine-type exopeptidase activity
HG15A2_33320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG15A2_33360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG15A2_33370	COG1078	dGTPase activity
HG15A2_33480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG15A2_33520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HG15A2_33530	COG0254	rRNA binding
HG15A2_33540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG15A2_33550	COG2890	protein-(glutamine-N5) methyltransferase activity
HG15A2_33590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_33620	COG4974	Belongs to the 'phage' integrase family
HG15A2_33650	COG0811	peptide transport
HG15A2_33710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG15A2_33720	COG1684	flagellar biosynthetic protein fliR
HG15A2_33730	COG1987	bacterial-type flagellum assembly
HG15A2_33740	COG1338	Plays a role in the flagellum-specific transport system
HG15A2_33790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG15A2_33800	COG1582	Flagellar protein (FlbD)
HG15A2_33820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG15A2_33860	COG1157	protein secretion by the type III secretion system
HG15A2_33880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_33900	COG1677	Flagellar hook-basal body complex protein FliE
HG15A2_33920	COG1815	bacterial-type flagellum-dependent cell motility
HG15A2_33940	COG3852	Histidine kinase
HG15A2_33980	COG0039	L-malate dehydrogenase activity
HG15A2_34000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG15A2_34010	COG1419	protein localization to endoplasmic reticulum
HG15A2_34040	COG1191	sigma factor activity
HG15A2_34080	COG0137	argininosuccinate synthase activity
HG15A2_34110	COG0540	Belongs to the ATCase OTCase family
HG15A2_34140	COG0745	RESPONSE REGULATOR receiver
HG15A2_34150	COG0445	tRNA wobble uridine modification
HG15A2_34200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG15A2_34210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG15A2_34240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG15A2_34270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG15A2_34290	COG0673	inositol 2-dehydrogenase activity
HG15A2_34310	COG0658	competence protein
HG15A2_34310	COG2333	competence protein COMEC
HG15A2_34330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG15A2_34340	COG1185	polyribonucleotide nucleotidyltransferase activity
HG15A2_34350	COG4191	Histidine kinase
HG15A2_34380	COG0640	Transcriptional regulator
HG15A2_34410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_34420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG15A2_34430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG15A2_34460	COG2885	chlorophyll binding
HG15A2_34470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG15A2_34480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HG15A2_34530	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_34570	COG1674	ftsk spoiiie
HG15A2_34580	COG0488	(ABC) transporter
HG15A2_34590	COG2226	methyltransferase
HG15A2_34600	COG0148	phosphopyruvate hydratase activity
HG15A2_34670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG15A2_34680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG15A2_34680	COG0519	Catalyzes the synthesis of GMP from XMP
HG15A2_34690	COG0488	(ABC) transporter
HG15A2_34730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG15A2_34760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG15A2_34810	COG0321	lipoyl(octanoyl) transferase activity
HG15A2_34810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HG15A2_34820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG15A2_34880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG15A2_34890	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG15A2_34900	COG0602	queuosine metabolic process
HG15A2_34950	COG0151	Belongs to the GarS family
HG15A2_34970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG15A2_35040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG15A2_35060	COG0109	protoheme IX farnesyltransferase activity
HG15A2_35070	COG1845	cytochrome c oxidase, subunit III
HG15A2_35070	COG1845	cytochrome c oxidase, subunit III
HG15A2_35090	COG1131	(ABC) transporter
HG15A2_35120	COG2322	membrane
HG15A2_35180	COG0653	protein targeting
HG15A2_35190	COG1519	Transferase
HG15A2_35220	COG1131	(ABC) transporter
HG15A2_35260	COG1045	serine acetyltransferase
HG15A2_35280	COG0805	protein transport
HG15A2_35290	COG1482	cell wall glycoprotein biosynthetic process
HG15A2_35310	COG1187	pseudouridine synthase activity
HG15A2_35320	COG0543	2 iron, 2 sulfur cluster binding
HG15A2_35330	COG0268	Binds directly to 16S ribosomal RNA
HG15A2_35380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_35390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG15A2_35460	COG0736	holo-[acyl-carrier-protein] synthase activity
HG15A2_35480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG15A2_35490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG15A2_35580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG15A2_35660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_35690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG15A2_35700	COG0589	response to stress
HG15A2_35730	COG3002	Belongs to the UPF0753 family
HG15A2_35740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG15A2_35750	COG1007	ATP synthesis coupled electron transport
HG15A2_35780	COG0288	reversible hydration of carbon dioxide
HG15A2_35790	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HG15A2_35810	COG0589	response to stress
HG15A2_35840	COG0589	response to stress
HG15A2_35870	COG4191	Histidine kinase
HG15A2_35880	COG2201	protein-glutamate methylesterase activity
HG15A2_35920	COG2204	response regulator
HG15A2_35970	COG0730	response to heat
HG15A2_35980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_35990	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG15A2_36010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_36030	COG1136	(ABC) transporter
HG15A2_36070	COG1305	Transglutaminase-like
HG15A2_36080	COG2308	Evidence 4 Homologs of previously reported genes of
HG15A2_36110	COG2308	Evidence 4 Homologs of previously reported genes of
HG15A2_36130	COG1253	flavin adenine dinucleotide binding
HG15A2_36170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_36180	COG0398	Pfam SNARE associated Golgi protein
HG15A2_36190	COG3842	ATPase activity
HG15A2_36210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG15A2_36270	COG0124	histidyl-tRNA synthetase
HG15A2_36310	COG0189	ligase activity
HG15A2_36310	COG4067	protein conserved in archaea
HG15A2_36320	COG0800	Aldolase
HG15A2_36330	COG0284	orotidine-5'-phosphate decarboxylase activity
HG15A2_36420	COG0667	Aldo Keto reductase
HG15A2_36450	COG1131	(ABC) transporter
HG15A2_36480	COG0159	tryptophan synthase activity
HG15A2_36490	COG0133	tryptophan synthase activity
HG15A2_36500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG15A2_36510	COG0457	Tetratricopeptide repeat
HG15A2_36510	COG0515	serine threonine protein kinase
HG15A2_36520	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HG15A2_36530	COG0347	Belongs to the P(II) protein family
HG15A2_36540	COG0004	ammonium transporteR
HG15A2_36550	COG2096	Adenosyltransferase
HG15A2_36560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_36650	COG4191	Histidine kinase
HG15A2_36670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG15A2_36680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG15A2_36690	COG0784	Response regulator, receiver
HG15A2_36690	COG2205	protein histidine kinase activity
HG15A2_36700	COG0328	RNA-DNA hybrid ribonuclease activity
HG15A2_36710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG15A2_36730	COG0515	serine threonine protein kinase
HG15A2_36730	COG2815	serine threonine protein kinase
HG15A2_36750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG15A2_36760	COG1201	RNA secondary structure unwinding
HG15A2_36770	COG0415	Belongs to the DNA photolyase family
HG15A2_36800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG15A2_36830	COG1136	(ABC) transporter
HG15A2_36830	COG0577	efflux transmembrane transporter activity
HG15A2_36840	COG1136	(ABC) transporter
HG15A2_36880	COG3386	PFAM SMP-30 Gluconolaconase
HG15A2_36920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HG15A2_36980	COG2188	Transcriptional regulator
HG15A2_37100	COG1609	Transcriptional regulator
HG15A2_37100	COG2207	Transcriptional regulator
HG15A2_37150	COG0658	competence protein
HG15A2_37150	COG2333	competence protein COMEC
HG15A2_37190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG15A2_37190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HG15A2_37220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_37230	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_37250	COG0673	inositol 2-dehydrogenase activity
HG15A2_37270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_37410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_37440	COG0673	inositol 2-dehydrogenase activity
HG15A2_37480	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_37660	COG2115	Belongs to the xylose isomerase family
HG15A2_37680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_37690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_37730	COG0704	Plays a role in the regulation of phosphate uptake
HG15A2_37740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG15A2_37750	COG0581	inorganic phosphate transmembrane transporter activity
HG15A2_37760	COG0573	inorganic phosphate transmembrane transporter activity
HG15A2_37770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG15A2_37780	COG5002	protein histidine kinase activity
HG15A2_37970	COG0217	transcriptional regulatory protein
HG15A2_37990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG15A2_38000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG15A2_38010	COG0195	Participates in both transcription termination and antitermination
HG15A2_38010	COG2251	uridine kinase activity
HG15A2_38020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_38050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_38060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_38070	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_38080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG15A2_38090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG15A2_38110	COG2255	four-way junction helicase activity
HG15A2_38150	COG0509	glycine decarboxylation via glycine cleavage system
HG15A2_38170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG15A2_38190	COG1454	alcohol dehydrogenase
HG15A2_38240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_38300	COG4536	flavin adenine dinucleotide binding
HG15A2_38350	COG0530	calcium, potassium:sodium antiporter activity
HG15A2_38370	COG0469	pyruvate kinase activity
HG15A2_38390	COG3693	PFAM glycoside hydrolase, family 10
HG15A2_38390	COG2382	esterase
HG15A2_38410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG15A2_38420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG15A2_38430	COG0142	geranyltranstransferase activity
HG15A2_38440	COG1722	exodeoxyribonuclease VII activity
HG15A2_38450	COG1570	exodeoxyribonuclease VII activity
HG15A2_38500	COG0037	tRNA processing
HG15A2_38520	COG1418	mRNA catabolic process
HG15A2_38530	COG1692	metallophosphoesterase
HG15A2_38590	COG1054	Belongs to the UPF0176 family
HG15A2_38610	COG0248	Ppx GppA phosphatase
HG15A2_38620	COG0196	riboflavin kinase activity
HG15A2_38630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_38650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG15A2_38660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG15A2_38710	COG0517	IMP dehydrogenase activity
HG15A2_38710	COG0516	GMP reductase activity
HG15A2_38730	COG3132	Protein of unknown function, DUF480
HG15A2_38760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG15A2_38770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_38780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_38800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG15A2_38820	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_38850	COG0825	malonyl-CoA metabolic process
HG15A2_38860	COG0515	serine threonine protein kinase
HG15A2_38860	COG2815	serine threonine protein kinase
HG15A2_38870	COG0668	transmembrane transport
HG15A2_38890	COG0101	tRNA pseudouridine synthase activity
HG15A2_38900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG15A2_38910	COG1490	D-aminoacyl-tRNA deacylase activity
HG15A2_38930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_38990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HG15A2_39010	COG0406	alpha-ribazole phosphatase activity
HG15A2_39080	COG0436	Aminotransferase
HG15A2_39120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG15A2_39210	COG0343	queuine tRNA-ribosyltransferase activity
HG15A2_39220	COG1862	Preprotein translocase
HG15A2_39230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG15A2_39390	COG3119	arylsulfatase activity
HG15A2_39410	COG3408	Glycogen debranching enzyme
HG15A2_39410	COG3119	arylsulfatase activity
HG15A2_39420	COG0702	epimerase
HG15A2_39440	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_39480	COG0481	GTPase activity
HG15A2_39510	COG0697	spore germination
HG15A2_39710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG15A2_39730	COG1017	nitric oxide dioxygenase activity
HG15A2_39730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG15A2_39760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG15A2_39770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG15A2_39840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG15A2_39850	COG5002	protein histidine kinase activity
HG15A2_39860	COG0745	RESPONSE REGULATOR receiver
HG15A2_39880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG15A2_39920	COG0259	pyridoxamine-phosphate oxidase activity
HG15A2_39940	COG0515	serine threonine protein kinase
HG15A2_39940	COG2815	serine threonine protein kinase
HG15A2_39950	COG0385	Bile acid
HG15A2_39970	COG2204	response regulator
HG15A2_39980	COG4191	Histidine kinase
HG15A2_40040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG15A2_40110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG15A2_40110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG15A2_40160	COG0646	methionine synthase
HG15A2_40160	COG1410	methionine synthase
HG15A2_40170	COG0129	dihydroxy-acid dehydratase activity
HG15A2_40340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG15A2_40340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG15A2_40350	COG1691	(AIR) carboxylase
HG15A2_40550	COG0673	inositol 2-dehydrogenase activity
HG15A2_40560	COG0657	acetylesterase activity
HG15A2_40660	COG2130	NADP-dependent
HG15A2_40680	COG3237	CsbD-like
HG15A2_40730	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG15A2_40740	COG3621	Patatin-like phospholipase
HG15A2_40760	COG0281	malic enzyme
HG15A2_40860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_40880	COG0306	phosphate transporter
HG15A2_40910	COG2226	methyltransferase
HG15A2_41060	COG1960	acyl-CoA dehydrogenase activity
HG15A2_41070	COG0529	Catalyzes the synthesis of activated sulfate
HG15A2_41090	COG1663	tetraacyldisaccharide 4'-kinase activity
HG15A2_41110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HG15A2_41120	COG1131	(ABC) transporter
HG15A2_41160	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HG15A2_41240	COG4941	Belongs to the sigma-70 factor family
HG15A2_41270	COG3795	YCII-related domain
HG15A2_41280	COG3795	YCII-related domain
HG15A2_41360	COG1459	type II secretion system
HG15A2_41480	COG1175	transmembrane transport
HG15A2_41490	COG0395	ABC-type sugar transport system, permease component
HG15A2_41500	COG3842	ATPase activity
HG15A2_41590	COG3119	arylsulfatase activity
HG15A2_41610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG15A2_41620	COG0584	glycerophosphoryl diester phosphodiesterase
HG15A2_41660	COG3119	arylsulfatase activity
HG15A2_41680	COG0584	glycerophosphoryl diester phosphodiesterase
HG15A2_41700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG15A2_41710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG15A2_41750	COG0673	inositol 2-dehydrogenase activity
HG15A2_41770	COG4251	negative regulation of phosphorylation
HG15A2_41820	COG0069	glutamate synthase activity
HG15A2_41860	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_41870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HG15A2_41870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG15A2_41950	COG2211	Major facilitator Superfamily
HG15A2_41980	COG3328	transposase activity
HG15A2_42040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG15A2_42160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG15A2_42160	COG0167	dihydroorotate dehydrogenase activity
HG15A2_42190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG15A2_42220	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_42270	COG3347	Dehydrogenase
HG15A2_42270	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_42300	COG3119	arylsulfatase activity
HG15A2_42330	COG3119	arylsulfatase activity
HG15A2_42340	COG3119	arylsulfatase activity
HG15A2_42350	COG3119	arylsulfatase activity
HG15A2_42360	COG0657	acetylesterase activity
HG15A2_42450	COG1940	carbohydrate kinase activity
HG15A2_42590	COG3119	arylsulfatase activity
HG15A2_42610	COG1472	Belongs to the glycosyl hydrolase 3 family
HG15A2_42630	COG1595	DNA-templated transcription, initiation
HG15A2_42690	COG3119	arylsulfatase activity
HG15A2_42940	COG3119	arylsulfatase activity
HG15A2_42960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_43020	COG3119	arylsulfatase activity
HG15A2_43040	COG3408	Glycogen debranching enzyme
HG15A2_43040	COG3119	arylsulfatase activity
HG15A2_43080	COG3119	arylsulfatase activity
HG15A2_43090	COG3119	arylsulfatase activity
HG15A2_43100	COG3119	arylsulfatase activity
HG15A2_43110	COG3119	arylsulfatase activity
HG15A2_43140	COG1082	Xylose isomerase domain protein TIM barrel
HG15A2_43150	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_43170	COG3119	arylsulfatase activity
HG15A2_43200	COG3119	arylsulfatase activity
HG15A2_43220	COG3119	arylsulfatase activity
HG15A2_43280	COG3119	arylsulfatase activity
HG15A2_43300	COG1164	Oligoendopeptidase f
HG15A2_43320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG15A2_43350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_43370	COG0107	imidazoleglycerol-phosphate synthase activity
HG15A2_43390	COG4067	protein conserved in archaea
HG15A2_43390	COG0189	ligase activity
HG15A2_43400	COG0189	ligase activity
HG15A2_43450	COG2022	thiamine diphosphate biosynthetic process
HG15A2_43460	COG1199	ATP-dependent helicase activity
HG15A2_43530	COG2442	InterPro IPR007367
HG15A2_43540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG15A2_43560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG15A2_43570	COG0163	prenyltransferase activity
HG15A2_43590	COG2226	methyltransferase
HG15A2_43600	COG2045	Belongs to the ComB family
HG15A2_43610	COG0423	glycine-tRNA ligase activity
HG15A2_43660	COG2267	carboxylic ester hydrolase activity
HG15A2_43690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG15A2_43770	COG3177	Filamentation induced by cAMP protein fic
HG15A2_43840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG15A2_43900	COG0189	ligase activity
HG15A2_43900	COG4067	protein conserved in archaea
HG15A2_43910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG15A2_43930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG15A2_43940	COG1704	LemA family
HG15A2_43950	COG0501	Belongs to the peptidase M48B family
HG15A2_43960	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HG15A2_43980	COG0519	Catalyzes the synthesis of GMP from XMP
HG15A2_44000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG15A2_44030	COG0347	Belongs to the P(II) protein family
HG15A2_44050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HG15A2_44070	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HG15A2_44110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG15A2_44120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_44140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG15A2_44150	COG0242	peptide deformylase activity
HG15A2_44170	COG0811	peptide transport
HG15A2_44300	COG0714	Associated with various cellular activities
HG15A2_44350	COG1247	-acetyltransferase
HG15A2_44380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_44390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_44400	COG1321	iron dependent repressor
HG15A2_44500	COG3237	CsbD-like
HG15A2_44560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_44610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG15A2_44630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG15A2_44640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG15A2_44650	COG1449	Belongs to the glycosyl hydrolase 57 family
HG15A2_44670	COG0297	glycogen (starch) synthase activity
HG15A2_44710	COG0513	Belongs to the DEAD box helicase family
HG15A2_44730	COG1840	ABC-type Fe3 transport system, periplasmic component
HG15A2_44740	COG1234	tRNA 3'-trailer cleavage
HG15A2_44780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG15A2_44800	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HG15A2_44840	COG0277	FAD linked oxidase domain protein
HG15A2_44870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG15A2_44910	COG0142	geranyltranstransferase activity
HG15A2_44960	COG0438	transferase activity, transferring glycosyl groups
HG15A2_44970	COG4191	Histidine kinase
HG15A2_44980	COG4566	intracellular signal transduction
HG15A2_45000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG15A2_45030	COG1136	(ABC) transporter
HG15A2_45120	COG0542	response to heat
HG15A2_45140	COG0352	thiamine-phosphate diphosphorylase activity
HG15A2_45170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG15A2_45210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG15A2_45220	COG0489	protein tyrosine kinase activity
HG15A2_45260	COG1994	Peptidase M50
HG15A2_45270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_45290	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HG15A2_45300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG15A2_45320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG15A2_45330	COG0215	cysteine-tRNA ligase activity
HG15A2_45360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG15A2_45370	COG0632	four-way junction helicase activity
HG15A2_45380	COG1073	alpha beta
HG15A2_45420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG15A2_45460	COG0442	prolyl-tRNA aminoacylation
HG15A2_45500	COG0557	exoribonuclease II activity
HG15A2_45510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG15A2_45520	COG0509	glycine decarboxylation via glycine cleavage system
HG15A2_45530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_45550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_45560	COG0457	Tetratricopeptide repeat
HG15A2_45560	COG0515	serine threonine protein kinase
HG15A2_45570	COG0457	Tetratricopeptide repeat
HG15A2_45570	COG0515	serine threonine protein kinase
HG15A2_45580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_45590	COG0095	Lipoate-protein ligase
HG15A2_45660	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HG15A2_45670	COG3239	Fatty acid desaturase
HG15A2_45750	COG1819	glycosyl
HG15A2_45790	COG0671	phosphoesterase, PA-phosphatase related
HG15A2_46010	COG2815	serine threonine protein kinase
HG15A2_46010	COG0515	serine threonine protein kinase
HG15A2_46020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG15A2_46050	COG0058	SHG alpha-glucan phosphorylase activity
HG15A2_46290	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG15A2_46550	COG1943	Transposase
HG15A2_46560	COG2010	Cytochrome c
HG15A2_46580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG15A2_46610	COG0745	RESPONSE REGULATOR receiver
HG15A2_46620	COG0745	RESPONSE REGULATOR receiver
HG15A2_46620	COG2205	protein histidine kinase activity
HG15A2_46620	COG3292	Two component regulator propeller
HG15A2_46630	COG1943	Transposase
HG15A2_46660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HG15A2_46730	COG1595	DNA-templated transcription, initiation
HG15A2_46750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG15A2_46760	COG1511	domain protein
HG15A2_46760	COG3264	Mechanosensitive ion channel
HG15A2_46890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_46900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG15A2_46910	COG0616	signal peptide processing
HG15A2_46940	COG0750	zinc metalloprotease
HG15A2_46950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG15A2_46960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG15A2_46990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG15A2_47000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG15A2_47190	COG0601	transmembrane transport
HG15A2_47200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG15A2_47280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG15A2_47290	COG1090	epimerase
HG15A2_47320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_47370	COG0187	DNA topoisomerase II activity
HG15A2_47460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HG15A2_47470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG15A2_47480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG15A2_47500	COG1530	ribonuclease E activity
HG15A2_47550	COG0758	DNA mediated transformation
HG15A2_47560	COG1595	DNA-templated transcription, initiation
HG15A2_47630	COG4172	Belongs to the ABC transporter superfamily
HG15A2_47650	COG2062	phosphohistidine phosphatase, SixA
HG15A2_47690	COG5487	UPF0391 membrane protein
HG15A2_47710	COG0822	iron-sulfur transferase activity
HG15A2_47720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG15A2_47750	COG1858	cytochrome C peroxidase
HG15A2_47760	COG0450	alkyl hydroperoxide reductase
HG15A2_47770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG15A2_47780	COG0673	inositol 2-dehydrogenase activity
HG15A2_47860	COG1192	Involved in chromosome partitioning
HG15A2_47900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG15A2_47960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_47970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG15A2_47980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG15A2_47990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG15A2_48040	COG0659	secondary active sulfate transmembrane transporter activity
HG15A2_48120	COG0530	calcium, potassium:sodium antiporter activity
HG15A2_48380	COG0191	fructose-bisphosphate aldolase activity
HG15A2_48410	COG0203	ribosomal protein L17
HG15A2_48420	COG0202	RNA polymerase activity
HG15A2_48430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG15A2_48440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG15A2_48450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG15A2_48460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG15A2_48480	COG0563	adenylate kinase activity
HG15A2_48490	COG0201	protein transport
HG15A2_48500	COG0200	Binds to the 23S rRNA
HG15A2_48510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG15A2_48520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG15A2_48530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG15A2_48540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG15A2_48550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG15A2_48560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG15A2_48570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG15A2_48580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG15A2_48590	COG0255	Belongs to the universal ribosomal protein uL29 family
HG15A2_48600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG15A2_48610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG15A2_48620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG15A2_48630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG15A2_48640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG15A2_48650	COG0089	rRNA binding
HG15A2_48660	COG0088	Forms part of the polypeptide exit tunnel
HG15A2_48670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG15A2_48680	COG0051	transcription antitermination factor activity, RNA binding
HG15A2_48700	COG3707	response regulator
HG15A2_48710	COG3237	CsbD-like
HG15A2_48800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG15A2_48810	COG0049	tRNA binding
HG15A2_48830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG15A2_48840	COG0085	RNA polymerase activity
HG15A2_48850	COG0222	ribosome binding
HG15A2_48860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG15A2_48870	COG0081	regulation of translation
HG15A2_48880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG15A2_48890	COG0250	Participates in transcription elongation, termination and antitermination
HG15A2_48920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG15A2_49010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_49030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG15A2_49060	COG1598	PFAM Uncharacterised protein family UPF0150
HG15A2_49380	COG1733	regulation of RNA biosynthetic process
HG15A2_49500	COG0438	transferase activity, transferring glycosyl groups
HG15A2_49520	COG3177	Filamentation induced by cAMP protein fic
HG15A2_49550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG15A2_49560	COG0517	IMP dehydrogenase activity
HG15A2_49560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG15A2_49590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG15A2_49600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_49650	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_49690	COG1704	LemA family
HG15A2_49720	COG0165	Argininosuccinate lyase
HG15A2_49740	COG2204	response regulator
HG15A2_49760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG15A2_49780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves