locus-tag	class	description
HUW48_00020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_00050	COG1970	mechanosensitive ion channel activity
HUW48_00120	COG1278	Cold shock
HUW48_00145	COG2226	methyltransferase
HUW48_00155	COG0798	PFAM Bile acid sodium symporter
HUW48_00165	COG1742	UPF0060 membrane protein
HUW48_00170	COG2217	Heavy metal translocating P-type atpase
HUW48_00215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_00280	COG2217	Heavy metal translocating P-type atpase
HUW48_00295	COG2217	Heavy metal translocating P-type atpase
HUW48_00300	COG1396	sequence-specific DNA binding
HUW48_00325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW48_00355	COG0739	heme binding
HUW48_00355	COG0741	lytic transglycosylase activity
HUW48_00355	COG1196	nuclear chromosome segregation
HUW48_00460	COG4227	nucleotidyltransferase activity
HUW48_00465	COG1192	Involved in chromosome partitioning
HUW48_00505	COG2198	Histidine kinase
HUW48_00505	COG0784	Response regulator, receiver
HUW48_00505	COG0643	Histidine kinase
HUW48_00510	COG5002	protein histidine kinase activity
HUW48_00520	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_00525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW48_00560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_00615	COG1295	ribonuclease BN
HUW48_00680	COG1917	Cupin 2, conserved barrel domain protein
HUW48_00680	COG2207	Transcriptional regulator
HUW48_00700	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_00715	COG4191	Histidine kinase
HUW48_00720	COG0784	Response regulator, receiver
HUW48_00725	COG2198	Histidine kinase
HUW48_00725	COG2205	protein histidine kinase activity
HUW48_00725	COG0784	Response regulator, receiver
HUW48_00730	COG0745	RESPONSE REGULATOR receiver
HUW48_00735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_00760	COG2217	Heavy metal translocating P-type atpase
HUW48_00795	COG3278	Belongs to the heme-copper respiratory oxidase family
HUW48_00805	COG2010	Cytochrome c
HUW48_00835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW48_00865	COG4245	von Willebrand factor, type A
HUW48_00890	COG2084	Dehydrogenase
HUW48_00915	COG4977	sequence-specific DNA binding
HUW48_00940	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_00945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW48_00955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_00980	COG1725	Transcriptional regulator
HUW48_00995	COG2814	Major facilitator Superfamily
HUW48_01005	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_01015	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_01030	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_01050	COG0662	Cupin 2, conserved barrel domain protein
HUW48_01065	COG0745	RESPONSE REGULATOR receiver
HUW48_01065	COG3292	Two component regulator propeller
HUW48_01065	COG2205	protein histidine kinase activity
HUW48_01075	COG0577	efflux transmembrane transporter activity
HUW48_01080	COG0577	efflux transmembrane transporter activity
HUW48_01085	COG0577	efflux transmembrane transporter activity
HUW48_01090	COG0577	efflux transmembrane transporter activity
HUW48_01100	COG0577	efflux transmembrane transporter activity
HUW48_01120	COG2197	response regulator
HUW48_01135	COG1733	regulation of RNA biosynthetic process
HUW48_01150	COG0577	efflux transmembrane transporter activity
HUW48_01155	COG0577	efflux transmembrane transporter activity
HUW48_01160	COG1136	(ABC) transporter
HUW48_01160	COG0577	efflux transmembrane transporter activity
HUW48_01180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW48_01185	COG0577	efflux transmembrane transporter activity
HUW48_01190	COG0577	efflux transmembrane transporter activity
HUW48_01200	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUW48_01205	COG3387	PFAM Glycoside hydrolase 15-related
HUW48_01220	COG4771	TonB-dependent receptor
HUW48_01225	COG0561	phosphatase activity
HUW48_01235	COG3291	Pkd domain containing protein
HUW48_01255	COG3292	Two component regulator propeller
HUW48_01255	COG0745	RESPONSE REGULATOR receiver
HUW48_01255	COG2205	protein histidine kinase activity
HUW48_01280	COG1902	pentaerythritol trinitrate reductase activity
HUW48_01285	COG0667	Aldo Keto reductase
HUW48_01290	COG0300	oxidoreductase activity
HUW48_01315	COG0702	epimerase
HUW48_01330	COG1999	signal sequence binding
HUW48_01345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW48_01350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW48_01355	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW48_01360	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_01365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_01370	COG4654	Cytochrome c, class I
HUW48_01380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW48_01385	COG1085	galactose-1-phosphate uridylyltransferase
HUW48_01390	COG0673	inositol 2-dehydrogenase activity
HUW48_01395	COG0442	prolyl-tRNA aminoacylation
HUW48_01430	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_01450	COG4864	UPF0365 protein
HUW48_01465	COG2223	nitrite transmembrane transporter activity
HUW48_01475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW48_01475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW48_01515	COG1704	LemA family
HUW48_01535	COG2852	Protein conserved in bacteria
HUW48_01560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUW48_01565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW48_01575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW48_01580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW48_01590	COG0335	large ribosomal subunit rRNA binding
HUW48_01595	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW48_01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW48_01605	COG0228	four-way junction DNA binding
HUW48_01615	COG0463	Glycosyl transferase, family 2
HUW48_01620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_01635	COG0564	pseudouridine synthase activity
HUW48_01640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUW48_01650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW48_01660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW48_01670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUW48_01675	COG2095	MarC family integral membrane protein
HUW48_01680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW48_01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW48_01715	COG0300	oxidoreductase activity
HUW48_01720	COG0300	oxidoreductase activity
HUW48_01730	COG0542	response to heat
HUW48_01735	COG1187	pseudouridine synthase activity
HUW48_01740	COG0443	Heat shock 70 kDa protein
HUW48_01745	COG4585	Histidine kinase
HUW48_01755	COG2197	response regulator
HUW48_01770	COG3851	Histidine kinase
HUW48_01820	COG1902	pentaerythritol trinitrate reductase activity
HUW48_01825	COG1515	deoxyribonuclease V activity
HUW48_01850	COG0517	IMP dehydrogenase activity
HUW48_01850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW48_01870	COG2366	antibiotic biosynthetic process
HUW48_01925	COG0346	lactoylglutathione lyase activity
HUW48_01930	COG2353	YceI-like domain
HUW48_01940	COG1940	carbohydrate kinase activity
HUW48_01945	COG2133	pyrroloquinoline quinone binding
HUW48_01950	COG1309	transcriptional regulator
HUW48_01980	COG2814	Major facilitator Superfamily
HUW48_01985	COG1505	serine-type exopeptidase activity
HUW48_02020	COG0792	nuclease activity
HUW48_02025	COG0166	Belongs to the GPI family
HUW48_02030	COG0321	lipoyl(octanoyl) transferase activity
HUW48_02060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_02080	COG1289	transmembrane transporter activity
HUW48_02085	COG0322	excinuclease ABC activity
HUW48_02110	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW48_02115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW48_02120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW48_02125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW48_02130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW48_02135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW48_02140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW48_02155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW48_02155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW48_02180	COG0431	NADPH-dependent FMN reductase
HUW48_02190	COG0488	(ABC) transporter
HUW48_02210	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUW48_02220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW48_02250	COG0006	proline dipeptidase activity
HUW48_02255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_02285	COG4993	Dehydrogenase
HUW48_02305	COG1446	asparaginase
HUW48_02325	COG0714	Associated with various cellular activities
HUW48_02335	COG4654	Cytochrome c, class I
HUW48_02360	COG2226	methyltransferase
HUW48_02400	COG1138	Cytochrome C-type biogenesis protein
HUW48_02405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_02410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUW48_02415	COG1278	Cold shock
HUW48_02430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW48_02435	COG0138	bifunctional purine biosynthesis protein purh
HUW48_02440	COG1077	Cell shape determining protein MreB Mrl
HUW48_02455	COG0768	penicillin binding
HUW48_02460	COG0772	Belongs to the SEDS family
HUW48_02485	COG0673	inositol 2-dehydrogenase activity
HUW48_02495	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_02560	COG4771	TonB-dependent receptor
HUW48_02580	COG0709	Synthesizes selenophosphate from selenide and ATP
HUW48_02585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUW48_02590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUW48_02605	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW48_02625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW48_02640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW48_02660	COG0564	pseudouridine synthase activity
HUW48_02670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW48_02685	COG0848	biopolymer transport protein
HUW48_02700	COG3956	TIGRFAM MazG family protein
HUW48_02705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW48_02710	COG1104	cysteine desulfurase activity
HUW48_02715	COG0009	L-threonylcarbamoyladenylate synthase
HUW48_02720	COG1611	Belongs to the LOG family
HUW48_02725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUW48_02730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW48_02735	COG1160	GTP binding
HUW48_02755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW48_02770	COG1022	Amp-dependent synthetase and ligase
HUW48_02780	COG1024	Enoyl-CoA hydratase
HUW48_02780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_02785	COG0183	Belongs to the thiolase family
HUW48_02795	COG1960	acyl-CoA dehydrogenase activity
HUW48_02805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW48_02815	COG4535	Mg2 and Co2 transporter CorC
HUW48_02820	COG0629	single-stranded DNA binding
HUW48_02825	COG1194	a g-specific adenine glycosylase
HUW48_02830	COG0776	regulation of translation
HUW48_02840	COG1530	ribonuclease E activity
HUW48_02865	COG0113	porphobilinogen synthase activity
HUW48_02875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW48_02880	COG2267	carboxylic ester hydrolase activity
HUW48_02890	COG0251	oxidation-reduction process
HUW48_02895	COG1921	L-seryl-tRNASec selenium transferase activity
HUW48_02925	COG1435	thymidine kinase activity
HUW48_02940	COG1381	Involved in DNA repair and RecF pathway recombination
HUW48_02950	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_02955	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_02960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW48_02965	COG0105	UTP biosynthetic process
HUW48_02980	COG5180	pathogenesis
HUW48_02980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW48_02985	COG0195	Participates in both transcription termination and antitermination
HUW48_03000	COG0215	cysteine-tRNA ligase activity
HUW48_03005	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUW48_03015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW48_03020	COG2873	o-acetylhomoserine
HUW48_03025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW48_03035	COG0590	tRNA wobble adenosine to inosine editing
HUW48_03050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW48_03055	COG1522	sequence-specific DNA binding
HUW48_03090	COG2755	lipolytic protein G-D-S-L family
HUW48_03095	COG2755	lipolytic protein G-D-S-L family
HUW48_03105	COG1629	transport
HUW48_03110	COG0702	epimerase
HUW48_03115	COG0745	RESPONSE REGULATOR receiver
HUW48_03115	COG2205	protein histidine kinase activity
HUW48_03115	COG0745	RESPONSE REGULATOR receiver
HUW48_03115	COG3292	Two component regulator propeller
HUW48_03115	COG3292	Two component regulator propeller
HUW48_03115	COG2205	protein histidine kinase activity
HUW48_03120	COG4771	TonB-dependent receptor
HUW48_03135	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_03140	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUW48_03145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_03150	COG0246	Mannitol dehydrogenase
HUW48_03155	COG2721	sulfolactate sulfo-lyase activity
HUW48_03160	COG1904	glucuronate isomerase
HUW48_03165	COG2271	Major facilitator Superfamily
HUW48_03175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUW48_03185	COG2755	lipolytic protein G-D-S-L family
HUW48_03190	COG4677	pectinesterase activity
HUW48_03250	COG3263	regulation of cellular component size
HUW48_03275	COG2382	esterase
HUW48_03285	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_03290	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_03315	COG0657	acetylesterase activity
HUW48_03315	COG2755	lipolytic protein G-D-S-L family
HUW48_03330	COG2382	esterase
HUW48_03335	COG2382	esterase
HUW48_03340	COG3693	PFAM glycoside hydrolase, family 10
HUW48_03340	COG2382	esterase
HUW48_03340	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_03345	COG3693	PFAM glycoside hydrolase, family 10
HUW48_03345	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_03345	COG2382	esterase
HUW48_03355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW48_03365	COG2382	esterase
HUW48_03375	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_03380	COG2851	Citrate transporter
HUW48_03410	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_03450	COG2197	response regulator
HUW48_03455	COG4585	Histidine kinase
HUW48_03460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_03465	COG2146	nitrite reductase [NAD(P)H] activity
HUW48_03465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_03475	COG2223	nitrite transmembrane transporter activity
HUW48_03480	COG0243	molybdopterin cofactor binding
HUW48_03490	COG0303	'Molybdopterin
HUW48_03505	COG0746	molybdenum cofactor guanylyltransferase activity
HUW48_03505	COG0315	cyclic pyranopterin monophosphate synthase activity
HUW48_03515	COG0314	molybdopterin synthase activity
HUW48_03525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUW48_03530	COG1007	ATP synthesis coupled electron transport
HUW48_03535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_03545	COG0713	ATP synthesis coupled electron transport
HUW48_03550	COG0839	Belongs to the complex I subunit 6 family
HUW48_03555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_03560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_03565	COG1034	ATP synthesis coupled electron transport
HUW48_03580	COG0649	NAD binding
HUW48_03585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_03590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_03595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_03600	COG2755	lipolytic protein G-D-S-L family
HUW48_03600	COG0657	acetylesterase activity
HUW48_03605	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_03610	COG1011	Hydrolase
HUW48_03625	COG0626	cystathionine gamma-synthase activity
HUW48_03635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW48_03650	COG0343	queuine tRNA-ribosyltransferase activity
HUW48_03655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW48_03665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW48_03670	COG0254	rRNA binding
HUW48_03675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_03685	COG0470	DNA polymerase III
HUW48_03690	COG0181	hydroxymethylbilane synthase activity
HUW48_03715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW48_03720	COG1331	Highly conserved protein containing a thioredoxin domain
HUW48_03730	COG0359	binds to the 23S rRNA
HUW48_03735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW48_03740	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW48_03750	COG0437	4 iron, 4 sulfur cluster binding
HUW48_03780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW48_03790	COG0109	protoheme IX farnesyltransferase activity
HUW48_03810	COG1999	signal sequence binding
HUW48_03815	COG2322	membrane
HUW48_03825	COG5000	phosphorelay sensor kinase activity
HUW48_03850	COG5001	Diguanylate cyclase
HUW48_03865	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW48_03870	COG3123	guanosine phosphorylase activity
HUW48_03885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUW48_03890	COG4654	Cytochrome c, class I
HUW48_03905	COG0612	Peptidase, M16
HUW48_03910	COG0438	transferase activity, transferring glycosyl groups
HUW48_03915	COG0006	proline dipeptidase activity
HUW48_03920	COG2885	chlorophyll binding
HUW48_03940	COG0419	ATPase involved in DNA repair
HUW48_03960	COG0584	glycerophosphoryl diester phosphodiesterase
HUW48_03965	COG1139	Iron-sulfur cluster binding protein
HUW48_03980	COG2234	aminopeptidase activity
HUW48_03985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW48_04000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW48_04010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW48_04020	COG2201	protein-glutamate methylesterase activity
HUW48_04045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_04050	COG0673	inositol 2-dehydrogenase activity
HUW48_04055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUW48_04075	COG3279	Response regulator of the LytR AlgR family
HUW48_04080	COG3275	phosphorelay sensor kinase activity
HUW48_04090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW48_04100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW48_04105	COG0006	proline dipeptidase activity
HUW48_04115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW48_04125	COG0552	protein localization to endoplasmic reticulum
HUW48_04135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_04140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HUW48_04145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW48_04150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUW48_04175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW48_04180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW48_04205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW48_04215	COG0745	RESPONSE REGULATOR receiver
HUW48_04220	COG5002	protein histidine kinase activity
HUW48_04225	COG0564	pseudouridine synthase activity
HUW48_04235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW48_04240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUW48_04245	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW48_04250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW48_04270	COG0714	Associated with various cellular activities
HUW48_04285	COG2172	sigma factor antagonist activity
HUW48_04300	COG0517	IMP dehydrogenase activity
HUW48_04300	COG0516	GMP reductase activity
HUW48_04315	COG1253	flavin adenine dinucleotide binding
HUW48_04325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW48_04340	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW48_04350	COG0667	Aldo Keto reductase
HUW48_04375	COG2003	Belongs to the UPF0758 family
HUW48_04385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_04385	COG0072	phenylalanine-tRNA ligase activity
HUW48_04400	COG1418	mRNA catabolic process
HUW48_04415	COG1609	Transcriptional regulator
HUW48_04420	COG4771	TonB-dependent receptor
HUW48_04425	COG0561	phosphatase activity
HUW48_04430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW48_04435	COG0673	inositol 2-dehydrogenase activity
HUW48_04465	COG0010	Belongs to the arginase family
HUW48_04475	COG2267	carboxylic ester hydrolase activity
HUW48_04505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_04520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_04530	COG0438	transferase activity, transferring glycosyl groups
HUW48_04540	COG0438	transferase activity, transferring glycosyl groups
HUW48_04550	COG1216	Glycosyl transferase, family 2
HUW48_04550	COG0463	Glycosyl transferase, family 2
HUW48_04600	COG0183	Belongs to the thiolase family
HUW48_04605	COG0101	tRNA pseudouridine synthase activity
HUW48_04610	COG1132	(ABC) transporter
HUW48_04620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW48_04635	COG4771	TonB-dependent receptor
HUW48_04640	COG0702	epimerase
HUW48_04675	COG0673	inositol 2-dehydrogenase activity
HUW48_04710	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_04720	COG2222	sugar isomerase
HUW48_04730	COG5652	VanZ like family
HUW48_04735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW48_04750	COG4946	Tricorn protease homolog
HUW48_04750	COG1506	peptidase
HUW48_04750	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_04755	COG1629	transport
HUW48_04760	COG0702	epimerase
HUW48_04775	COG1349	DNA-binding transcription factor activity
HUW48_04785	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_04795	COG0420	3'-5' exonuclease activity
HUW48_04800	COG2201	protein-glutamate methylesterase activity
HUW48_04805	COG0039	L-malate dehydrogenase activity
HUW48_04810	COG0037	tRNA processing
HUW48_04850	COG0497	DNA recombination
HUW48_04855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUW48_04860	COG0662	Cupin 2, conserved barrel domain protein
HUW48_04860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW48_04865	COG3237	CsbD-like
HUW48_04875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW48_04915	COG0492	ferredoxin-NADP+ reductase activity
HUW48_04940	COG0489	protein tyrosine kinase activity
HUW48_04940	COG3206	protein involved in exopolysaccharide biosynthesis
HUW48_04955	COG1215	transferase activity, transferring glycosyl groups
HUW48_05000	COG0110	maltose O-acetyltransferase activity
HUW48_05005	COG0463	Glycosyl transferase, family 2
HUW48_05020	COG0297	glycogen (starch) synthase activity
HUW48_05070	COG1216	Glycosyl transferase, family 2
HUW48_05070	COG0463	Glycosyl transferase, family 2
HUW48_05075	COG0726	polysaccharide deacetylase
HUW48_05080	COG1215	transferase activity, transferring glycosyl groups
HUW48_05085	COG1216	Glycosyl transferase, family 2
HUW48_05105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_05110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUW48_05115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_05120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW48_05140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_05145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_05150	COG0673	inositol 2-dehydrogenase activity
HUW48_05170	COG1555	photosystem II stabilization
HUW48_05170	COG1596	polysaccharide export
HUW48_05185	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_05195	COG3158	transport of potassium into the cell
HUW48_05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW48_05210	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUW48_05220	COG4206	TonB-dependent receptor
HUW48_05220	COG1629	transport
HUW48_05235	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_05240	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_05255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUW48_05255	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_05265	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_05270	COG0180	Tryptophanyl-tRNA synthetase
HUW48_05280	COG1234	tRNA 3'-trailer cleavage
HUW48_05290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW48_05295	COG0019	diaminopimelate decarboxylase activity
HUW48_05300	COG0527	aspartate kinase activity
HUW48_05310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_05320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW48_05325	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_05330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW48_05335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW48_05365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_05385	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_05400	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_05460	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_05525	COG0667	Aldo Keto reductase
HUW48_05545	COG0702	epimerase
HUW48_05550	COG4771	TonB-dependent receptor
HUW48_05555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW48_05620	COG4771	TonB-dependent receptor
HUW48_05625	COG0702	epimerase
HUW48_05640	COG3254	rhamnose metabolic process
HUW48_05650	COG1063	alcohol dehydrogenase
HUW48_05690	COG1216	Glycosyl transferase, family 2
HUW48_05710	COG1216	Glycosyl transferase, family 2
HUW48_05730	COG0463	Glycosyl transferase, family 2
HUW48_05730	COG1216	Glycosyl transferase, family 2
HUW48_05760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW48_05770	COG0563	adenylate kinase activity
HUW48_05775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW48_05780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW48_05785	COG0484	heat shock protein binding
HUW48_05790	COG4152	abc transporter atp-binding protein
HUW48_05800	COG3781	membrane
HUW48_05805	COG0316	Belongs to the HesB IscA family
HUW48_05820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_05835	COG0438	transferase activity, transferring glycosyl groups
HUW48_05840	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_05845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW48_05870	COG0175	sulfate reduction
HUW48_05875	COG0529	Catalyzes the synthesis of activated sulfate
HUW48_05885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW48_05895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUW48_05905	COG0175	sulfate reduction
HUW48_05910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_05915	COG0697	spore germination
HUW48_05925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW48_05935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW48_05940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW48_05960	COG4067	protein conserved in archaea
HUW48_05960	COG0189	ligase activity
HUW48_05965	COG0189	ligase activity
HUW48_05970	COG3608	succinylglutamate desuccinylase aspartoacylase
HUW48_05990	COG0702	epimerase
HUW48_05995	COG0596	Alpha beta hydrolase
HUW48_06010	COG3618	amidohydrolase
HUW48_06025	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW48_06030	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_06040	COG0673	inositol 2-dehydrogenase activity
HUW48_06080	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_06095	COG1090	epimerase
HUW48_06100	COG0302	gtp cyclohydrolase
HUW48_06110	COG3118	belongs to the thioredoxin family
HUW48_06140	COG1388	LysM domain
HUW48_06140	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW48_06160	COG1053	succinate dehydrogenase
HUW48_06175	COG4941	Belongs to the sigma-70 factor family
HUW48_06210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_06250	COG0527	aspartate kinase activity
HUW48_06260	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_06275	COG0673	inositol 2-dehydrogenase activity
HUW48_06295	COG2207	Transcriptional regulator
HUW48_06295	COG0662	Cupin 2, conserved barrel domain protein
HUW48_06320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW48_06325	COG2885	chlorophyll binding
HUW48_06335	COG0247	lactate metabolic process
HUW48_06335	COG2181	nitrate reductase activity
HUW48_06340	COG2181	nitrate reductase activity
HUW48_06340	COG0247	lactate metabolic process
HUW48_06385	COG4191	Histidine kinase
HUW48_06395	COG4974	Belongs to the 'phage' integrase family
HUW48_06435	COG1215	transferase activity, transferring glycosyl groups
HUW48_06440	COG0110	maltose O-acetyltransferase activity
HUW48_06450	COG2755	lipolytic protein G-D-S-L family
HUW48_06450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW48_06460	COG1216	Glycosyl transferase, family 2
HUW48_06460	COG0463	Glycosyl transferase, family 2
HUW48_06480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_06485	COG0745	RESPONSE REGULATOR receiver
HUW48_06490	COG5002	protein histidine kinase activity
HUW48_06490	COG2198	Histidine kinase
HUW48_06490	COG0784	Response regulator, receiver
HUW48_06495	COG1215	transferase activity, transferring glycosyl groups
HUW48_06530	COG0668	transmembrane transport
HUW48_06535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUW48_06550	COG2314	TM2 domain
HUW48_06555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_06575	COG0531	amino acid
HUW48_06585	COG1266	CAAX protease self-immunity
HUW48_06590	COG4589	Belongs to the CDS family
HUW48_06595	COG0793	Belongs to the peptidase S41A family
HUW48_06600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUW48_06610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW48_06615	COG0612	Peptidase, M16
HUW48_06620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW48_06645	COG0799	negative regulation of ribosome biogenesis
HUW48_06650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW48_06655	COG1556	Lactate utilization protein
HUW48_06700	COG0154	amidase activity
HUW48_06730	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUW48_06750	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_06780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUW48_06845	COG1597	lipid kinase activity
HUW48_06900	COG3590	peptidase
HUW48_06905	COG3876	Protein conserved in bacteria
HUW48_06910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW48_06915	COG0616	signal peptide processing
HUW48_06925	COG0067	glutamate synthase
HUW48_06925	COG0069	glutamate synthase activity
HUW48_06925	COG0070	glutamate synthase
HUW48_06975	COG1136	(ABC) transporter
HUW48_06985	COG4191	Histidine kinase
HUW48_06990	COG3279	Response regulator of the LytR AlgR family
HUW48_06995	COG4251	negative regulation of phosphorylation
HUW48_07005	COG2755	lipolytic protein G-D-S-L family
HUW48_07005	COG0657	acetylesterase activity
HUW48_07010	COG3118	belongs to the thioredoxin family
HUW48_07035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW48_07055	COG0531	amino acid
HUW48_07065	COG2259	Doxx family
HUW48_07135	COG2353	YceI-like domain
HUW48_07195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW48_07235	COG5654	RES domain protein
HUW48_07275	COG1295	ribonuclease BN
HUW48_07310	COG1253	flavin adenine dinucleotide binding
HUW48_07315	COG1253	flavin adenine dinucleotide binding
HUW48_07350	COG3547	Transposase (IS116 IS110 IS902 family)
HUW48_07425	COG0196	riboflavin kinase activity
HUW48_07430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW48_07435	COG1968	undecaprenyl-diphosphatase activity
HUW48_07445	COG2177	Part of the ABC transporter FtsEX involved in
HUW48_07455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW48_07470	COG0439	Biotin carboxylase
HUW48_07480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW48_07485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW48_07490	COG0416	fatty acid biosynthetic process
HUW48_07495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUW48_07505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUW48_07510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW48_07515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW48_07520	COG2239	Acts as a magnesium transporter
HUW48_07525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_07530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_07565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUW48_07575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_07590	COG0346	lactoylglutathione lyase activity
HUW48_07600	COG0517	IMP dehydrogenase activity
HUW48_07600	COG0617	tRNA 3'-terminal CCA addition
HUW48_07600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW48_07615	COG1695	Transcriptional regulator
HUW48_07640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW48_07645	COG0784	Response regulator, receiver
HUW48_07650	COG4251	negative regulation of phosphorylation
HUW48_07655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUW48_07660	COG2045	Belongs to the ComB family
HUW48_07665	COG1694	Mazg nucleotide pyrophosphohydrolase
HUW48_07670	COG1490	D-aminoacyl-tRNA deacylase activity
HUW48_07680	COG0598	Magnesium transport protein CorA
HUW48_07690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_07705	COG2244	polysaccharide biosynthetic process
HUW48_07710	COG1215	transferase activity, transferring glycosyl groups
HUW48_07750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_07755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUW48_07760	COG1162	GTPase activity
HUW48_07780	COG0527	aspartate kinase activity
HUW48_07795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW48_07810	COG2226	methyltransferase
HUW48_07820	COG4221	oxidoreductase activity
HUW48_07835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW48_07840	COG0328	RNA-DNA hybrid ribonuclease activity
HUW48_07850	COG2095	MarC family integral membrane protein
HUW48_07860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUW48_07865	COG4974	Belongs to the 'phage' integrase family
HUW48_07890	COG0167	dihydroorotate dehydrogenase activity
HUW48_07895	COG1674	ftsk spoiiie
HUW48_07910	COG0247	lactate metabolic process
HUW48_07910	COG0277	FAD linked oxidase domain protein
HUW48_07920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUW48_07925	COG0791	NLP P60 protein
HUW48_07935	COG0539	negative regulation of cytoplasmic translation
HUW48_07945	COG2197	response regulator
HUW48_07960	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW48_07960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW48_07970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUW48_07985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW48_07990	COG0681	Belongs to the peptidase S26 family
HUW48_07995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW48_08005	COG1475	DNA binding
HUW48_08010	COG1192	Involved in chromosome partitioning
HUW48_08015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_08020	COG0747	negative chemotaxis
HUW48_08025	COG0706	membrane insertase activity
HUW48_08030	COG0504	CTP synthase activity
HUW48_08065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_08070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_08090	COG3217	Mosc domain protein beta barrel domain protein
HUW48_08090	COG0633	Ferredoxin
HUW48_08100	COG1129	ABC transporter
HUW48_08100	COG0842	Transport permease protein
HUW48_08105	COG0842	Transport permease protein
HUW48_08110	COG1131	(ABC) transporter
HUW48_08115	COG1131	(ABC) transporter
HUW48_08120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_08140	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW48_08145	COG2166	iron-sulfur cluster assembly
HUW48_08155	COG0719	Fe-S assembly protein
HUW48_08160	COG0396	ATPase activity
HUW48_08165	COG0719	Fe-S assembly protein
HUW48_08170	COG0316	Belongs to the HesB IscA family
HUW48_08185	COG0492	ferredoxin-NADP+ reductase activity
HUW48_08200	COG0739	heme binding
HUW48_08215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW48_08280	COG2814	Major facilitator Superfamily
HUW48_08300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_08305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW48_08310	COG2080	2 iron, 2 sulfur cluster binding
HUW48_08320	COG0028	Belongs to the TPP enzyme family
HUW48_08340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_08350	COG1278	Cold shock
HUW48_08365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW48_08395	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_08400	COG1187	pseudouridine synthase activity
HUW48_08405	COG2197	response regulator
HUW48_08480	COG3546	catalase activity
HUW48_08485	COG0667	Aldo Keto reductase
HUW48_08505	COG0604	alcohol dehydrogenase
HUW48_08535	COG4302	ethanolamine ammonia-lyase activity
HUW48_08550	COG4771	TonB-dependent receptor
HUW48_08555	COG0702	epimerase
HUW48_08575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW48_08585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_08610	COG3162	membrane
HUW48_08625	COG0183	Belongs to the thiolase family
HUW48_08635	COG2304	oxidoreductase activity
HUW48_08730	COG0039	L-malate dehydrogenase activity
HUW48_08830	COG0402	S-adenosylhomocysteine deaminase activity
HUW48_08850	COG0745	RESPONSE REGULATOR receiver
HUW48_08850	COG2205	protein histidine kinase activity
HUW48_08850	COG3292	Two component regulator propeller
HUW48_08875	COG0730	response to heat
HUW48_08890	COG2814	Major facilitator Superfamily
HUW48_08920	COG0431	NADPH-dependent FMN reductase
HUW48_08975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW48_09015	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HUW48_09030	COG3547	Transposase (IS116 IS110 IS902 family)
HUW48_09045	COG0210	DNA helicase
HUW48_09075	COG3292	Two component regulator propeller
HUW48_09075	COG2205	protein histidine kinase activity
HUW48_09075	COG0745	RESPONSE REGULATOR receiver
HUW48_09090	COG3781	membrane
HUW48_09100	COG1132	(ABC) transporter
HUW48_09120	COG2514	catechol 2,3-dioxygenase activity
HUW48_09125	COG1473	amidohydrolase
HUW48_09175	COG3794	PFAM blue (type 1) copper domain protein
HUW48_09180	COG1595	DNA-templated transcription, initiation
HUW48_09190	COG0302	gtp cyclohydrolase
HUW48_09195	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_09225	COG1943	Transposase
HUW48_09230	COG2610	gluconate transmembrane transporter activity
HUW48_09240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW48_09270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_09275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_09290	COG2217	Heavy metal translocating P-type atpase
HUW48_09300	COG1741	Belongs to the pirin family
HUW48_09335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW48_09340	COG3585	molybdate ion transport
HUW48_09340	COG2005	Transcriptional regulator
HUW48_09370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_09415	COG1609	Transcriptional regulator
HUW48_09425	COG0673	inositol 2-dehydrogenase activity
HUW48_09435	COG2814	Major facilitator Superfamily
HUW48_09440	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_09445	COG0673	inositol 2-dehydrogenase activity
HUW48_09455	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_09470	COG4993	Dehydrogenase
HUW48_09485	COG1629	transport
HUW48_09495	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_09505	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_09540	COG4771	TonB-dependent receptor
HUW48_09545	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_09555	COG4206	TonB-dependent receptor
HUW48_09555	COG1629	transport
HUW48_09565	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_09570	COG1609	Transcriptional regulator
HUW48_09575	COG3734	2-keto-3-deoxy-galactonokinase
HUW48_09595	COG1196	nuclear chromosome segregation
HUW48_09610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW48_09615	COG3104	oligopeptide transport
HUW48_09625	COG0459	protein refolding
HUW48_09630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW48_09650	COG3604	Transcriptional regulator
HUW48_09655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_09670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW48_09675	COG1663	tetraacyldisaccharide 4'-kinase activity
HUW48_09705	COG0577	efflux transmembrane transporter activity
HUW48_09725	COG1119	ATPase activity
HUW48_09735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_09740	COG1368	sulfuric ester hydrolase activity
HUW48_09755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUW48_09765	COG2315	Protein conserved in bacteria
HUW48_09780	COG0784	Response regulator, receiver
HUW48_09780	COG2205	protein histidine kinase activity
HUW48_09785	COG0495	leucyl-tRNA aminoacylation
HUW48_09795	COG2382	esterase
HUW48_09795	COG3693	PFAM glycoside hydrolase, family 10
HUW48_09810	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HUW48_09815	COG1047	Peptidyl-prolyl cis-trans
HUW48_09845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUW48_09850	COG2223	nitrite transmembrane transporter activity
HUW48_09855	COG2201	protein-glutamate methylesterase activity
HUW48_09895	COG4191	Histidine kinase
HUW48_09895	COG0784	Response regulator, receiver
HUW48_09930	COG2766	serine protein kinase
HUW48_09940	COG2719	SpoVR family
HUW48_09965	COG5002	protein histidine kinase activity
HUW48_10040	COG0247	lactate metabolic process
HUW48_10045	COG1139	Iron-sulfur cluster binding protein
HUW48_10050	COG1556	Lactate utilization protein
HUW48_10060	COG4095	Psort location CytoplasmicMembrane, score
HUW48_10095	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW48_10100	COG5002	protein histidine kinase activity
HUW48_10105	COG1278	Cold shock
HUW48_10140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUW48_10170	COG2171	N-acyltransferase activity
HUW48_10175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_10195	COG0488	(ABC) transporter
HUW48_10260	COG1199	ATP-dependent helicase activity
HUW48_10260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW48_10270	COG0628	permease
HUW48_10290	COG4771	TonB-dependent receptor
HUW48_10300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW48_10305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUW48_10310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW48_10315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW48_10335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW48_10340	COG1185	polyribonucleotide nucleotidyltransferase activity
HUW48_10345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW48_10350	COG0492	ferredoxin-NADP+ reductase activity
HUW48_10355	COG0739	heme binding
HUW48_10365	COG0439	Biotin carboxylase
HUW48_10370	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_10380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW48_10405	COG0811	peptide transport
HUW48_10410	COG0848	biopolymer transport protein
HUW48_10425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW48_10430	COG0135	phosphoribosylanthranilate isomerase activity
HUW48_10435	COG0482	sulfurtransferase activity
HUW48_10450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW48_10465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUW48_10475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW48_10480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW48_10480	COG0131	Imidazoleglycerol-phosphate dehydratase
HUW48_10485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUW48_10490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUW48_10495	COG0107	imidazoleglycerol-phosphate synthase activity
HUW48_10500	COG0140	phosphoribosyl-ATP diphosphatase activity
HUW48_10500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUW48_10505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_10515	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUW48_10555	COG3275	phosphorelay sensor kinase activity
HUW48_10560	COG3279	Response regulator of the LytR AlgR family
HUW48_10570	COG1722	exodeoxyribonuclease VII activity
HUW48_10575	COG1570	exodeoxyribonuclease VII activity
HUW48_10590	COG0793	Belongs to the peptidase S41A family
HUW48_10600	COG3685	Protein conserved in bacteria
HUW48_10630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUW48_10645	COG3339	Conserved Protein
HUW48_10650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_10655	COG2081	HI0933 family
HUW48_10665	COG0673	inositol 2-dehydrogenase activity
HUW48_10675	COG3239	Fatty acid desaturase
HUW48_10680	COG2076	Multidrug Resistance protein
HUW48_10685	COG0513	Belongs to the DEAD box helicase family
HUW48_10695	COG1074	ATP-dependent DNA helicase activity
HUW48_10705	COG2887	Belongs to the helicase family. UvrD subfamily
HUW48_10710	COG1652	LysM domain
HUW48_10735	COG1741	Belongs to the pirin family
HUW48_10745	COG0514	ATP-dependent DNA helicase (RecQ)
HUW48_10755	COG1950	PFAM Membrane protein of
HUW48_10760	COG0010	Belongs to the arginase family
HUW48_10765	COG1776	CheC inhibitor of MCP methylation
HUW48_10770	COG0643	Histidine kinase
HUW48_10770	COG2198	Histidine kinase
HUW48_10770	COG2198	Histidine kinase
HUW48_10770	COG0643	Histidine kinase
HUW48_10775	COG2201	protein-glutamate methylesterase activity
HUW48_10785	COG0840	transmembrane signaling receptor activity
HUW48_10790	COG1192	Involved in chromosome partitioning
HUW48_10795	COG0588	phosphoglycerate mutase activity
HUW48_10805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW48_10810	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_10815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_10820	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUW48_10825	COG0436	Aminotransferase
HUW48_10830	COG0534	Mate efflux family protein
HUW48_10840	COG0723	plastoquinol--plastocyanin reductase activity
HUW48_10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW48_10845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_10870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUW48_10875	COG2363	Small membrane protein
HUW48_10885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_10895	COG0494	nUDIX hydrolase
HUW48_10905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW48_10915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW48_10940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUW48_10960	COG0012	GTP binding
HUW48_10975	COG0346	lactoylglutathione lyase activity
HUW48_10995	COG0488	(ABC) transporter
HUW48_11020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUW48_11040	COG0406	alpha-ribazole phosphatase activity
HUW48_11055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW48_11070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW48_11085	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_11100	COG1446	asparaginase
HUW48_11110	COG1940	carbohydrate kinase activity
HUW48_11120	COG1629	transport
HUW48_11120	COG4206	TonB-dependent receptor
HUW48_11130	COG1609	Transcriptional regulator
HUW48_11145	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_11145	COG3347	Dehydrogenase
HUW48_11150	COG4952	isomerase
HUW48_11160	COG4771	TonB-dependent receptor
HUW48_11165	COG0702	epimerase
HUW48_11185	COG0673	inositol 2-dehydrogenase activity
HUW48_11200	COG0745	RESPONSE REGULATOR receiver
HUW48_11235	COG1629	transport
HUW48_11240	COG0702	epimerase
HUW48_11275	COG3254	rhamnose metabolic process
HUW48_11290	COG1725	Transcriptional regulator
HUW48_11315	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW48_11320	COG2814	Major facilitator Superfamily
HUW48_11340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW48_11350	COG0463	Glycosyl transferase, family 2
HUW48_11400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW48_11420	COG0137	argininosuccinate synthase activity
HUW48_11425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUW48_11430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW48_11440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW48_11445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUW48_11455	COG0165	Argininosuccinate lyase
HUW48_11460	COG5002	protein histidine kinase activity
HUW48_11475	COG0673	inositol 2-dehydrogenase activity
HUW48_11480	COG0673	inositol 2-dehydrogenase activity
HUW48_11495	COG0024	Methionine aminopeptidase
HUW48_11500	COG0673	inositol 2-dehydrogenase activity
HUW48_11520	COG1063	alcohol dehydrogenase
HUW48_11555	COG0793	Belongs to the peptidase S41A family
HUW48_11580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_11635	COG2217	Heavy metal translocating P-type atpase
HUW48_11660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_11675	COG5297	Belongs to the glycosyl hydrolase family 6
HUW48_11675	COG3250	beta-galactosidase activity
HUW48_11705	COG1506	peptidase
HUW48_11705	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_11705	COG4946	Tricorn protease homolog
HUW48_11710	COG0583	DNA-binding transcription factor activity
HUW48_11720	COG0667	Aldo Keto reductase
HUW48_11725	COG0667	Aldo Keto reductase
HUW48_11735	COG0596	Alpha beta hydrolase
HUW48_11765	COG1538	Outer membrane efflux protein
HUW48_11770	COG2502	aspartate--ammonia ligase
HUW48_11785	COG1678	Uncharacterized ACR, COG1678
HUW48_11800	COG0424	maF-like protein
HUW48_11805	COG0667	Aldo Keto reductase
HUW48_11820	COG3483	tryptophan 2,3-dioxygenase activity
HUW48_11825	COG1760	l-serine dehydratase
HUW48_11860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW48_11880	COG0517	IMP dehydrogenase activity
HUW48_11885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_11890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_11900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_11900	COG0649	NAD binding
HUW48_11905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUW48_11910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_11920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_11925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_11930	COG0839	Belongs to the complex I subunit 6 family
HUW48_11935	COG0713	ATP synthesis coupled electron transport
HUW48_11940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW48_11950	COG1007	ATP synthesis coupled electron transport
HUW48_11965	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUW48_12005	COG0022	dehydrogenase e1 component
HUW48_12010	COG0408	coproporphyrinogen oxidase activity
HUW48_12030	COG0671	phosphoesterase, PA-phosphatase related
HUW48_12055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_12060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW48_12075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_12080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW48_12085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW48_12100	COG0758	DNA mediated transformation
HUW48_12110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW48_12145	COG2132	Multicopper oxidase
HUW48_12180	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HUW48_12205	COG4206	TonB-dependent receptor
HUW48_12205	COG1629	transport
HUW48_12220	COG3275	phosphorelay sensor kinase activity
HUW48_12240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_12255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW48_12255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_12260	COG0730	response to heat
HUW48_12275	COG3119	arylsulfatase activity
HUW48_12290	COG5002	protein histidine kinase activity
HUW48_12415	COG2003	Belongs to the UPF0758 family
HUW48_12440	COG4206	TonB-dependent receptor
HUW48_12440	COG1629	transport
HUW48_12455	COG0038	chloride channel
HUW48_12460	COG0577	efflux transmembrane transporter activity
HUW48_12495	COG3275	phosphorelay sensor kinase activity
HUW48_12500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_12520	COG0825	malonyl-CoA metabolic process
HUW48_12525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_12560	COG2267	carboxylic ester hydrolase activity
HUW48_12565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_12575	COG1215	transferase activity, transferring glycosyl groups
HUW48_12595	COG5343	regulation of RNA biosynthetic process
HUW48_12605	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_12645	COG1643	Atp-dependent helicase
HUW48_12655	COG2161	toxin-antitoxin pair type II binding
HUW48_12705	COG5002	protein histidine kinase activity
HUW48_12730	COG0668	transmembrane transport
HUW48_12735	COG2354	Protein conserved in bacteria
HUW48_12750	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUW48_12760	COG0501	Belongs to the peptidase M48B family
HUW48_12775	COG3250	beta-galactosidase activity
HUW48_12780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_12795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_12835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW48_12845	COG0730	response to heat
HUW48_12850	COG0450	alkyl hydroperoxide reductase
HUW48_12865	COG1959	2 iron, 2 sulfur cluster binding
HUW48_12870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW48_12875	COG0737	Belongs to the 5'-nucleotidase family
HUW48_12905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_12910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_12910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_12915	COG4191	Histidine kinase
HUW48_12915	COG0784	Response regulator, receiver
HUW48_12940	COG0778	Nitroreductase
HUW48_12960	COG2963	transposase activity
HUW48_12965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUW48_12980	COG2091	lysine biosynthetic process via aminoadipic acid
HUW48_12990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW48_12990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW48_12995	COG0436	Aminotransferase
HUW48_13005	COG1215	transferase activity, transferring glycosyl groups
HUW48_13010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUW48_13040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW48_13045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW48_13060	COG0492	ferredoxin-NADP+ reductase activity
HUW48_13065	COG3852	Histidine kinase
HUW48_13095	COG4251	negative regulation of phosphorylation
HUW48_13120	COG0339	signal peptide processing
HUW48_13135	COG3590	peptidase
HUW48_13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_13150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_13180	COG3119	arylsulfatase activity
HUW48_13220	COG1904	glucuronate isomerase
HUW48_13225	COG0246	Mannitol dehydrogenase
HUW48_13230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW48_13245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_13245	COG3153	acetyltransferase
HUW48_13250	COG0124	histidyl-tRNA synthetase
HUW48_13255	COG2986	histidine ammonia-lyase
HUW48_13270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUW48_13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_13285	COG0022	dehydrogenase e1 component
HUW48_13335	COG2089	acid synthase
HUW48_13345	COG0028	Belongs to the TPP enzyme family
HUW48_13375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUW48_13390	COG0590	tRNA wobble adenosine to inosine editing
HUW48_13395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW48_13410	COG1086	Polysaccharide biosynthesis protein
HUW48_13420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_13430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW48_13450	COG2089	acid synthase
HUW48_13490	COG2884	Cell division ATP-binding protein ftsE
HUW48_13500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW48_13515	COG3237	CsbD-like
HUW48_13520	COG0519	Catalyzes the synthesis of GMP from XMP
HUW48_13520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUW48_13530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUW48_13565	COG1131	(ABC) transporter
HUW48_13570	COG0300	oxidoreductase activity
HUW48_13575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW48_13610	COG2169	Transcriptional regulator
HUW48_13640	COG0640	Transcriptional regulator
HUW48_13690	COG2271	Major facilitator Superfamily
HUW48_13705	COG4251	negative regulation of phosphorylation
HUW48_13710	COG1073	alpha beta
HUW48_13720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUW48_13740	COG0110	maltose O-acetyltransferase activity
HUW48_13760	COG4221	oxidoreductase activity
HUW48_13780	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_13800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW48_13815	COG1064	alcohol dehydrogenase
HUW48_13820	COG2080	2 iron, 2 sulfur cluster binding
HUW48_13825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW48_13830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_13835	COG2192	nodulation
HUW48_13850	COG0561	phosphatase activity
HUW48_13855	COG4771	TonB-dependent receptor
HUW48_13920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_13940	COG4771	TonB-dependent receptor
HUW48_13945	COG0726	polysaccharide deacetylase
HUW48_13990	COG0745	RESPONSE REGULATOR receiver
HUW48_13995	COG3850	Histidine kinase
HUW48_13995	COG5002	protein histidine kinase activity
HUW48_14040	COG4585	Histidine kinase
HUW48_14045	COG2197	response regulator
HUW48_14060	COG0277	FAD linked oxidase domain protein
HUW48_14075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW48_14090	COG0667	Aldo Keto reductase
HUW48_14105	COG0346	lactoylglutathione lyase activity
HUW48_14140	COG0288	reversible hydration of carbon dioxide
HUW48_14155	COG0745	RESPONSE REGULATOR receiver
HUW48_14165	COG1070	Carbohydrate kinase
HUW48_14170	COG2115	Belongs to the xylose isomerase family
HUW48_14180	COG2010	Cytochrome c
HUW48_14185	COG1999	signal sequence binding
HUW48_14215	COG1858	cytochrome C peroxidase
HUW48_14225	COG0673	inositol 2-dehydrogenase activity
HUW48_14240	COG2721	sulfolactate sulfo-lyase activity
HUW48_14285	COG2308	Evidence 4 Homologs of previously reported genes of
HUW48_14340	COG5002	protein histidine kinase activity
HUW48_14360	COG1252	NADH dehydrogenase
HUW48_14375	COG5002	protein histidine kinase activity
HUW48_14390	COG3275	phosphorelay sensor kinase activity
HUW48_14405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW48_14405	COG1017	nitric oxide dioxygenase activity
HUW48_14420	COG4251	negative regulation of phosphorylation
HUW48_14430	COG2172	sigma factor antagonist activity
HUW48_14435	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW48_14440	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW48_14455	COG2963	transposase activity
HUW48_14480	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_14495	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW48_14525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW48_14540	COG2378	regulation of single-species biofilm formation
HUW48_14555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW48_14565	COG3396	Phenylacetate-CoA oxygenase
HUW48_14580	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW48_14610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW48_14615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_14620	COG0116	Belongs to the methyltransferase superfamily
HUW48_14625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW48_14640	COG1193	negative regulation of DNA recombination
HUW48_14685	COG0406	alpha-ribazole phosphatase activity
HUW48_14705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_14710	COG1064	alcohol dehydrogenase
HUW48_14715	COG0673	inositol 2-dehydrogenase activity
HUW48_14720	COG0438	transferase activity, transferring glycosyl groups
HUW48_14750	COG0022	dehydrogenase e1 component
HUW48_14780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW48_14785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW48_14790	COG2270	Major facilitator Superfamily
HUW48_14815	COG1690	Belongs to the RtcB family
HUW48_14820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_14840	COG3530	Putative quorum-sensing-regulated virulence factor
HUW48_14860	COG0628	permease
HUW48_14880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW48_14880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW48_14890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW48_14895	COG0159	tryptophan synthase activity
HUW48_14900	COG0133	tryptophan synthase activity
HUW48_14905	COG0135	phosphoribosylanthranilate isomerase activity
HUW48_14910	COG0134	indole-3-glycerol-phosphate synthase activity
HUW48_14915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW48_14920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW48_14920	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW48_14930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW48_14940	COG0366	Alpha amylase catalytic
HUW48_14980	COG1289	transmembrane transporter activity
HUW48_14990	COG0824	Thioesterase
HUW48_14995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUW48_15005	COG0009	L-threonylcarbamoyladenylate synthase
HUW48_15020	COG0542	response to heat
HUW48_15025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW48_15030	COG1363	Peptidase, m42
HUW48_15035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW48_15040	COG0789	Transcriptional regulator
HUW48_15050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW48_15135	COG3275	phosphorelay sensor kinase activity
HUW48_15155	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW48_15165	COG1404	Belongs to the peptidase S8 family
HUW48_15165	COG4412	M6 family metalloprotease domain protein
HUW48_15185	COG3853	Toxic anion resistance protein (TelA)
HUW48_15195	COG2271	Major facilitator Superfamily
HUW48_15200	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_15210	COG0542	response to heat
HUW48_15245	COG0673	inositol 2-dehydrogenase activity
HUW48_15270	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_15285	COG1309	transcriptional regulator
HUW48_15315	COG0628	permease
HUW48_15345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW48_15350	COG0673	inositol 2-dehydrogenase activity
HUW48_15460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_15485	COG1929	Belongs to the glycerate kinase type-1 family
HUW48_15490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_15500	COG0579	oxidoreductase
HUW48_15505	COG2378	regulation of single-species biofilm formation
HUW48_15555	COG2885	chlorophyll binding
HUW48_15560	COG0602	queuosine metabolic process
HUW48_15565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW48_15570	COG0481	GTPase activity
HUW48_15580	COG1703	isobutyryl-CoA mutase activity
HUW48_15580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_15580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_15590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW48_15605	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW48_15610	COG0126	phosphoglycerate kinase activity
HUW48_15625	COG3321	synthase
HUW48_15625	COG0604	alcohol dehydrogenase
HUW48_15630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUW48_15645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW48_15645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW48_15660	COG0358	DNA primase activity
HUW48_15670	COG0489	protein tyrosine kinase activity
HUW48_15675	COG0316	Belongs to the HesB IscA family
HUW48_15675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUW48_15685	COG1335	isochorismatase
HUW48_15700	COG0514	ATP-dependent DNA helicase (RecQ)
HUW48_15715	COG1136	(ABC) transporter
HUW48_15725	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW48_15730	COG1764	response to oxidative stress
HUW48_15740	COG0531	amino acid
HUW48_15750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUW48_15765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW48_15770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW48_15775	COG0772	Belongs to the SEDS family
HUW48_15780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW48_15785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW48_15790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW48_15795	COG0768	penicillin binding
HUW48_15805	COG0275	rRNA processing
HUW48_15810	COG2001	Belongs to the MraZ family
HUW48_15825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW48_15850	COG1595	DNA-templated transcription, initiation
HUW48_15870	COG0658	competence protein
HUW48_15870	COG2333	competence protein COMEC
HUW48_15880	COG1702	phosphate starvation-inducible protein PhoH
HUW48_15900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW48_15920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW48_15945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUW48_15950	COG2255	four-way junction helicase activity
HUW48_15960	COG1960	acyl-CoA dehydrogenase activity
HUW48_15980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW48_16000	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUW48_16000	COG3409	Peptidoglycan-binding domain 1 protein
HUW48_16010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUW48_16025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW48_16030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW48_16035	COG0247	lactate metabolic process
HUW48_16045	COG0248	Ppx GppA phosphatase
HUW48_16050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW48_16060	COG0004	ammonium transporteR
HUW48_16080	COG1621	beta-fructofuranosidase activity
HUW48_16085	COG1621	beta-fructofuranosidase activity
HUW48_16090	COG1621	beta-fructofuranosidase activity
HUW48_16100	COG4771	TonB-dependent receptor
HUW48_16110	COG2814	Major facilitator Superfamily
HUW48_16115	COG2205	protein histidine kinase activity
HUW48_16115	COG3292	Two component regulator propeller
HUW48_16115	COG0745	RESPONSE REGULATOR receiver
HUW48_16125	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW48_16140	COG2197	response regulator
HUW48_16155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_16175	COG2814	Major facilitator Superfamily
HUW48_16190	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_16205	COG2610	gluconate transmembrane transporter activity
HUW48_16210	COG0129	dihydroxy-acid dehydratase activity
HUW48_16215	COG0800	Aldolase
HUW48_16240	COG1629	transport
HUW48_16250	COG2885	chlorophyll binding
HUW48_16320	COG1501	Belongs to the glycosyl hydrolase 31 family
HUW48_16335	COG3781	membrane
HUW48_16365	COG1132	(ABC) transporter
HUW48_16370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW48_16380	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_16390	COG1862	Preprotein translocase
HUW48_16400	COG0237	dephospho-CoA kinase activity
HUW48_16405	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_16410	COG3661	Belongs to the glycosyl hydrolase 67 family
HUW48_16495	COG2252	PERMEase
HUW48_16505	COG1733	regulation of RNA biosynthetic process
HUW48_16560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUW48_16565	COG2086	electron transfer activity
HUW48_16595	COG5002	protein histidine kinase activity
HUW48_16600	COG0745	RESPONSE REGULATOR receiver
HUW48_16610	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_16615	COG0415	Belongs to the DNA photolyase family
HUW48_16670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW48_16675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW48_16695	COG0829	nickel cation binding
HUW48_16705	COG0832	Belongs to the urease beta subunit family
HUW48_16745	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_16750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW48_16755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW48_16765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW48_16770	COG0698	ribose 5-phosphate isomerase
HUW48_16790	COG2814	Major facilitator Superfamily
HUW48_16795	COG0667	Aldo Keto reductase
HUW48_16810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW48_16810	COG1796	DNA polymerase
HUW48_16830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW48_16835	COG0540	Belongs to the ATCase OTCase family
HUW48_16840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW48_16845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW48_16855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_16855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_16875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_16890	COG2814	Major facilitator Superfamily
HUW48_16900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUW48_16965	COG3279	Response regulator of the LytR AlgR family
HUW48_16970	COG0697	spore germination
HUW48_16980	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_16990	COG2201	protein-glutamate methylesterase activity
HUW48_17005	COG1595	DNA-templated transcription, initiation
HUW48_17010	COG1629	transport
HUW48_17010	COG4206	TonB-dependent receptor
HUW48_17035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW48_17040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW48_17045	COG1252	NADH dehydrogenase
HUW48_17060	COG1640	4-alpha-glucanotransferase
HUW48_17080	COG5002	protein histidine kinase activity
HUW48_17085	COG1228	amidohydrolase
HUW48_17090	COG3458	cephalosporin-C deacetylase activity
HUW48_17095	COG5002	protein histidine kinase activity
HUW48_17165	COG1629	transport
HUW48_17165	COG4206	TonB-dependent receptor
HUW48_17175	COG1187	pseudouridine synthase activity
HUW48_17180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUW48_17185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW48_17195	COG3844	kynureninase activity
HUW48_17200	COG3757	hydrolase, family 25
HUW48_17225	COG2514	catechol 2,3-dioxygenase activity
HUW48_17235	COG1695	Transcriptional regulator
HUW48_17270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_17275	COG0387	Pfam Sodium calcium exchanger
HUW48_17295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_17300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_17310	COG1538	Outer membrane efflux protein
HUW48_17345	COG1011	Hydrolase
HUW48_17380	COG1090	epimerase
HUW48_17395	COG0702	epimerase
HUW48_17400	COG1629	transport
HUW48_17405	COG0450	alkyl hydroperoxide reductase
HUW48_17435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW48_17460	COG2855	membrane
HUW48_17480	COG0702	epimerase
HUW48_17485	COG1629	transport
HUW48_17510	COG1733	regulation of RNA biosynthetic process
HUW48_17560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW48_17565	COG0702	epimerase
HUW48_17570	COG4771	TonB-dependent receptor
HUW48_17575	COG0305	Participates in initiation and elongation during chromosome replication
HUW48_17580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW48_17595	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW48_17605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_17610	COG2304	oxidoreductase activity
HUW48_17615	COG1595	DNA-templated transcription, initiation
HUW48_17635	COG3273	potassium ion transport
HUW48_17635	COG0471	metal ion transport
HUW48_17645	COG0205	6-phosphofructokinase activity
HUW48_17650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW48_17660	COG5002	protein histidine kinase activity
HUW48_17660	COG2198	Histidine kinase
HUW48_17660	COG0784	Response regulator, receiver
HUW48_17675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW48_17675	COG0321	lipoyl(octanoyl) transferase activity
HUW48_17680	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUW48_17700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_17725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUW48_17745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW48_17780	COG1278	Cold shock
HUW48_17805	COG5654	RES domain protein
HUW48_17815	COG3604	Transcriptional regulator
HUW48_17825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_17920	COG0626	cystathionine gamma-synthase activity
HUW48_17925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW48_17965	COG0077	Prephenate dehydratase
HUW48_17970	COG0436	Aminotransferase
HUW48_17975	COG1605	Chorismate mutase
HUW48_17975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW48_18015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUW48_18035	COG0247	lactate metabolic process
HUW48_18035	COG0277	FAD linked oxidase domain protein
HUW48_18070	COG2223	nitrite transmembrane transporter activity
HUW48_18080	COG0612	Peptidase, M16
HUW48_18085	COG2318	DinB family
HUW48_18105	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_18110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_18130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_18140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_18145	COG1132	(ABC) transporter
HUW48_18155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUW48_18165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW48_18170	COG2885	chlorophyll binding
HUW48_18185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUW48_18195	COG1764	response to oxidative stress
HUW48_18215	COG0612	Peptidase, M16
HUW48_18225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_18260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW48_18265	COG0601	transmembrane transport
HUW48_18280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW48_18285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUW48_18305	COG3401	FG-GAP repeat protein
HUW48_18305	COG2755	lipolytic protein G-D-S-L family
HUW48_18330	COG4771	TonB-dependent receptor
HUW48_18350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW48_18355	COG0280	phosphate acetyltransferase
HUW48_18355	COG0857	belongs to the CobB CobQ family
HUW48_18380	COG0667	Aldo Keto reductase
HUW48_18385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW48_18405	COG3848	Pyruvate phosphate dikinase
HUW48_18405	COG0574	Belongs to the PEP-utilizing enzyme family
HUW48_18415	COG0673	inositol 2-dehydrogenase activity
HUW48_18420	COG1404	Belongs to the peptidase S8 family
HUW48_18490	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_18510	COG3292	Two component regulator propeller
HUW48_18510	COG0745	RESPONSE REGULATOR receiver
HUW48_18510	COG2205	protein histidine kinase activity
HUW48_18520	COG2267	carboxylic ester hydrolase activity
HUW48_18525	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_18560	COG4771	TonB-dependent receptor
HUW48_18600	COG0640	Transcriptional regulator
HUW48_18625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW48_18645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_18695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW48_18750	COG4134	Bacterial extracellular solute-binding protein
HUW48_18765	COG1115	amino acid carrier protein
HUW48_18780	COG4654	Cytochrome c, class I
HUW48_18790	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_18830	COG4651	solute:proton antiporter activity
HUW48_18830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUW48_18875	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW48_18880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUW48_18890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW48_18895	COG1984	allophanate hydrolase subunit 2
HUW48_18910	COG0667	Aldo Keto reductase
HUW48_18920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW48_18950	COG3321	synthase
HUW48_18950	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_18950	COG0604	alcohol dehydrogenase
HUW48_18955	COG2706	6-phosphogluconolactonase activity
HUW48_18960	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_18965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW48_19015	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_19030	COG1136	(ABC) transporter
HUW48_19040	COG0700	Nucleoside recognition
HUW48_19050	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_19125	COG2205	protein histidine kinase activity
HUW48_19125	COG0745	RESPONSE REGULATOR receiver
HUW48_19125	COG3292	Two component regulator propeller
HUW48_19130	COG2996	Protein conserved in bacteria
HUW48_19150	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_19155	COG1940	carbohydrate kinase activity
HUW48_19155	COG1846	Transcriptional regulator
HUW48_19175	COG0346	lactoylglutathione lyase activity
HUW48_19185	COG0517	IMP dehydrogenase activity
HUW48_19185	COG1125	glycine betaine transport
HUW48_19190	COG1174	glycine betaine transport
HUW48_19195	COG3279	Response regulator of the LytR AlgR family
HUW48_19200	COG3275	phosphorelay sensor kinase activity
HUW48_19210	COG2353	YceI-like domain
HUW48_19225	COG0802	atpase or kinase
HUW48_19230	COG2204	response regulator
HUW48_19235	COG1078	dGTPase activity
HUW48_19245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_19250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW48_19250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUW48_19255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_19260	COG4133	protoheme IX ABC transporter activity
HUW48_19280	COG1058	Belongs to the CinA family
HUW48_19280	COG1546	Belongs to the CinA family
HUW48_19285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_19305	COG1136	(ABC) transporter
HUW48_19325	COG2204	response regulator
HUW48_19335	COG0277	FAD linked oxidase domain protein
HUW48_19350	COG4106	trans-aconitate 2-methyltransferase activity
HUW48_19360	COG2205	protein histidine kinase activity
HUW48_19360	COG0745	RESPONSE REGULATOR receiver
HUW48_19360	COG3292	Two component regulator propeller
HUW48_19365	COG0525	valine-tRNA ligase activity
HUW48_19375	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_19380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUW48_19400	COG0813	purine-nucleoside phosphorylase activity
HUW48_19425	COG0284	orotidine-5'-phosphate decarboxylase activity
HUW48_19455	COG0513	Belongs to the DEAD box helicase family
HUW48_19470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW48_19475	COG1129	ABC transporter
HUW48_19495	COG0204	Acyl-transferase
HUW48_19495	COG0318	PFAM AMP-dependent synthetase and ligase
HUW48_19500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW48_19510	COG1136	(ABC) transporter
HUW48_19560	COG4771	TonB-dependent receptor
HUW48_19570	COG4771	TonB-dependent receptor
HUW48_19580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW48_19600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW48_19605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW48_19610	COG0577	efflux transmembrane transporter activity
HUW48_19610	COG1136	(ABC) transporter
HUW48_19615	COG1611	Belongs to the LOG family
HUW48_19630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW48_19645	COG1024	Enoyl-CoA hydratase
HUW48_19655	COG0017	Asparaginyl-tRNA synthetase
HUW48_19675	COG0193	aminoacyl-tRNA hydrolase activity
HUW48_19680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUW48_19685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW48_19685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_19690	COG0571	ribonuclease III activity
HUW48_19695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_19700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW48_19710	COG0469	pyruvate kinase activity
HUW48_19715	COG0268	Binds directly to 16S ribosomal RNA
HUW48_19720	COG0429	hydrolase of the alpha beta-hydrolase fold
HUW48_19735	COG0366	Alpha amylase catalytic
HUW48_19745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW48_19760	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUW48_19780	COG4974	Belongs to the 'phage' integrase family
HUW48_19830	COG3728	DNA packaging
HUW48_19830	COG5484	DNA packaging
HUW48_19890	COG2135	peptidase activity
HUW48_19955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW48_19970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUW48_19980	COG1970	mechanosensitive ion channel activity
HUW48_19985	COG1024	Enoyl-CoA hydratase
HUW48_19995	COG0756	dUTP diphosphatase activity
HUW48_20020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_20025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_20030	COG0154	amidase activity
HUW48_20035	COG0791	NLP P60 protein
HUW48_20035	COG1388	LysM domain
HUW48_20040	COG0280	phosphate acetyltransferase
HUW48_20040	COG0281	malic enzyme
HUW48_20045	COG0632	four-way junction helicase activity
HUW48_20055	COG0509	glycine decarboxylation via glycine cleavage system
HUW48_20065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_20070	COG1561	YicC-like family, N-terminal region
HUW48_20075	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW48_20095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_20100	COG1183	phosphatidylcholine synthase activity
HUW48_20130	COG2885	chlorophyll binding
HUW48_20145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW48_20160	COG3118	belongs to the thioredoxin family
HUW48_20175	COG0022	dehydrogenase e1 component
HUW48_20180	COG0612	Peptidase, M16
HUW48_20190	COG0667	Aldo Keto reductase
HUW48_20215	COG0492	ferredoxin-NADP+ reductase activity
HUW48_20235	COG0488	(ABC) transporter
HUW48_20250	COG1121	(ABC) transporter
HUW48_20290	COG2814	Major facilitator Superfamily
HUW48_20305	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_20310	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_20315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_20320	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_20330	COG1473	amidohydrolase
HUW48_20340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUW48_20345	COG0653	protein targeting
HUW48_20350	COG0248	Ppx GppA phosphatase
HUW48_20355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW48_20355	COG0116	Belongs to the methyltransferase superfamily
HUW48_20360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW48_20400	COG0148	phosphopyruvate hydratase activity
HUW48_20405	COG0505	Belongs to the CarA family
HUW48_20410	COG0203	ribosomal protein L17
HUW48_20415	COG0202	RNA polymerase activity
HUW48_20420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW48_20425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW48_20430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW48_20435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW48_20440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW48_20445	COG0024	Methionine aminopeptidase
HUW48_20450	COG0201	protein transport
HUW48_20455	COG0200	Binds to the 23S rRNA
HUW48_20460	COG1841	ribosomal large subunit assembly
HUW48_20465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW48_20470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW48_20475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW48_20480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW48_20485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW48_20490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW48_20495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW48_20500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW48_20505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUW48_20510	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW48_20515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW48_20520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW48_20525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW48_20530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW48_20535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW48_20540	COG0089	rRNA binding
HUW48_20545	COG0088	Forms part of the polypeptide exit tunnel
HUW48_20550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW48_20555	COG0051	transcription antitermination factor activity, RNA binding
HUW48_20560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW48_20565	COG0049	tRNA binding
HUW48_20570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW48_20585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUW48_20590	COG0085	RNA polymerase activity
HUW48_20595	COG0222	ribosome binding
HUW48_20600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW48_20605	COG0081	regulation of translation
HUW48_20610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW48_20650	COG0308	aminopeptidase N
HUW48_20660	COG0528	UMP kinase activity
HUW48_20665	COG0233	cytoplasmic translational termination
HUW48_20695	COG0191	fructose-bisphosphate aldolase activity
HUW48_20705	COG0004	ammonium transporteR
HUW48_20710	COG0788	formyltetrahydrofolate deformylase activity
HUW48_20720	COG3142	Participates in the control of copper homeostasis
HUW48_20735	COG1428	Deoxynucleoside kinase
HUW48_20745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW48_20750	COG0194	GDP metabolic process
HUW48_20760	COG1595	DNA-templated transcription, initiation
HUW48_20775	COG0463	Glycosyl transferase, family 2
HUW48_20780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW48_20790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW48_20805	COG3220	belongs to the UPF0276 family
HUW48_20810	COG2094	Belongs to the DNA glycosylase MPG family
HUW48_20820	COG4206	TonB-dependent receptor
HUW48_20840	COG1007	ATP synthesis coupled electron transport
HUW48_20850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW48_20855	COG0713	ATP synthesis coupled electron transport
HUW48_20860	COG0839	Belongs to the complex I subunit 6 family
HUW48_20870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_20875	COG0754	glutathionylspermidine amidase activity
HUW48_20885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW48_20895	COG0488	(ABC) transporter
HUW48_20905	COG0217	transcriptional regulatory protein
HUW48_20910	COG0513	Belongs to the DEAD box helicase family
HUW48_20915	COG1575	Belongs to the MenA family. Type 1 subfamily
HUW48_20920	COG0386	Belongs to the glutathione peroxidase family
HUW48_20925	COG0018	arginyl-trna synthetase
HUW48_20940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW48_20945	COG0463	Glycosyl transferase, family 2
HUW48_20970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW48_20985	COG0671	phosphoesterase, PA-phosphatase related
HUW48_20990	COG0671	phosphoesterase, PA-phosphatase related
HUW48_21000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW48_21020	COG0463	Glycosyl transferase, family 2
HUW48_21035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW48_21075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW48_21090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW48_21100	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW48_21105	COG0740	serine-type endopeptidase activity
HUW48_21110	COG4268	DNA restriction-modification system
HUW48_21115	COG1401	restriction endodeoxyribonuclease activity
HUW48_21120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW48_21125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_21135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW48_21140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW48_21145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_21150	COG2814	Major facilitator Superfamily
HUW48_21170	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_21230	COG1464	Belongs to the NlpA lipoprotein family
HUW48_21235	COG2011	ABC-type metal ion transport system permease component
HUW48_21255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW48_21275	COG1278	Cold shock
HUW48_21290	COG1774	PSP1 C-terminal conserved region
HUW48_21350	COG0326	Molecular chaperone. Has ATPase activity
HUW48_21375	COG0596	Alpha beta hydrolase
HUW48_21395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_21420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_21430	COG0367	asparagine synthase
HUW48_21435	COG0791	NLP P60 protein
HUW48_21450	COG0673	inositol 2-dehydrogenase activity
HUW48_21470	COG3119	arylsulfatase activity
HUW48_21475	COG3119	arylsulfatase activity
HUW48_21495	COG0583	DNA-binding transcription factor activity
HUW48_21520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_21525	COG2353	YceI-like domain
HUW48_21545	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_21560	COG2201	protein-glutamate methylesterase activity
HUW48_21570	COG1301	dicarboxylic acid transport
HUW48_21580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_21595	COG1058	Belongs to the CinA family
HUW48_21595	COG1546	Belongs to the CinA family
HUW48_21615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_21630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUW48_21635	COG0783	Belongs to the Dps family
HUW48_21690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW48_21695	COG3842	ATPase activity
HUW48_21705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW48_21710	COG0681	Belongs to the peptidase S26 family
HUW48_21730	COG1609	Transcriptional regulator
HUW48_21765	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUW48_21785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW48_21790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_21805	COG1309	transcriptional regulator
HUW48_21810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW48_21815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_21845	COG0305	Participates in initiation and elongation during chromosome replication
HUW48_21870	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUW48_21875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUW48_21895	COG1401	restriction endodeoxyribonuclease activity
HUW48_21995	COG2197	response regulator
HUW48_22000	COG4585	Histidine kinase
HUW48_22040	COG0587	DNA-directed DNA polymerase activity
HUW48_22050	COG1396	sequence-specific DNA binding
HUW48_22085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_22085	COG2010	Cytochrome c
HUW48_22090	COG2080	2 iron, 2 sulfur cluster binding
HUW48_22110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW48_22135	COG0673	inositol 2-dehydrogenase activity
HUW48_22145	COG0598	Magnesium transport protein CorA
HUW48_22150	COG0531	amino acid
HUW48_22165	COG2226	methyltransferase
HUW48_22180	COG0318	PFAM AMP-dependent synthetase and ligase
HUW48_22195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW48_22300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW48_22310	COG0861	Integral membrane protein TerC family
HUW48_22315	COG1666	GTP binding
HUW48_22335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW48_22345	COG0436	Aminotransferase
HUW48_22370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW48_22380	COG0438	transferase activity, transferring glycosyl groups
HUW48_22385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW48_22440	COG2205	protein histidine kinase activity
HUW48_22440	COG0784	Response regulator, receiver
HUW48_22450	COG0243	molybdopterin cofactor binding
HUW48_22465	COG2323	membrane
HUW48_22490	COG1214	PFAM Peptidase M22, glycoprotease
HUW48_22490	COG0456	acetyltransferase
HUW48_22525	COG0531	amino acid
HUW48_22585	COG4771	TonB-dependent receptor
HUW48_22595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW48_22600	COG0601	transmembrane transport
HUW48_22615	COG0793	Belongs to the peptidase S41A family
HUW48_22665	COG4181	ATPase activity
HUW48_22675	COG2198	Histidine kinase
HUW48_22675	COG2205	protein histidine kinase activity
HUW48_22675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW48_22675	COG0784	Response regulator, receiver
HUW48_22685	COG1073	alpha beta
HUW48_22690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW48_22695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUW48_22700	COG0440	acetolactate synthase activity
HUW48_22705	COG0028	Belongs to the TPP enzyme family
HUW48_22710	COG0129	dihydroxy-acid dehydratase activity
HUW48_22715	COG0527	aspartate kinase activity
HUW48_22715	COG0460	homoserine dehydrogenase
HUW48_22720	COG0083	homoserine kinase activity
HUW48_22725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW48_22730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW48_22735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW48_22740	COG0066	3-isopropylmalate dehydratase activity
HUW48_22745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_22750	COG4585	Histidine kinase
HUW48_22765	COG0667	Aldo Keto reductase
HUW48_22775	COG0242	peptide deformylase activity
HUW48_22790	COG1295	ribonuclease BN
HUW48_22805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUW48_22825	COG3011	Protein conserved in bacteria
HUW48_22875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_22880	COG1136	(ABC) transporter
HUW48_22880	COG0577	efflux transmembrane transporter activity
HUW48_22890	COG0577	efflux transmembrane transporter activity
HUW48_22890	COG1136	(ABC) transporter
HUW48_22895	COG1136	(ABC) transporter
HUW48_22895	COG0577	efflux transmembrane transporter activity
HUW48_22910	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_22915	COG0567	Dehydrogenase, E1 component
HUW48_22930	COG2201	protein-glutamate methylesterase activity
HUW48_22935	COG2323	membrane
HUW48_22960	COG1027	Aspartate ammonia-lyase
HUW48_23005	COG1629	transport
HUW48_23030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_23035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_23040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_23045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_23050	COG3586	endonuclease activity
HUW48_23055	COG0649	NAD binding
HUW48_23075	COG0702	epimerase
HUW48_23080	COG4771	TonB-dependent receptor
HUW48_23110	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_23140	COG4771	TonB-dependent receptor
HUW48_23170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW48_23180	COG2197	response regulator
HUW48_23185	COG1528	Iron-storage protein
HUW48_23245	COG0501	Belongs to the peptidase M48B family
HUW48_23255	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_23275	COG0612	Peptidase, M16
HUW48_23290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW48_23295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW48_23310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUW48_23345	COG3254	rhamnose metabolic process
HUW48_23350	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_23355	COG1063	alcohol dehydrogenase
HUW48_23360	COG0667	Aldo Keto reductase
HUW48_23370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW48_23380	COG1132	(ABC) transporter
HUW48_23395	COG0606	chelatase, subunit chli
HUW48_23410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW48_23415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW48_23425	COG2264	protein methyltransferase activity
HUW48_23435	COG0149	triose-phosphate isomerase activity
HUW48_23485	COG0463	Glycosyl transferase, family 2
HUW48_23490	COG2137	regulation of response to DNA damage stimulus
HUW48_23505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUW48_23540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW48_23555	COG4895	conserved protein (DUF2196)
HUW48_23570	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_23575	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_23595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW48_23595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUW48_23605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW48_23610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW48_23620	COG2304	oxidoreductase activity
HUW48_23640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW48_23670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_23690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUW48_23695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUW48_23760	COG2160	L-arabinose isomerase activity
HUW48_23790	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_23840	COG0673	inositol 2-dehydrogenase activity
HUW48_23855	COG0628	permease
HUW48_23870	COG3279	Response regulator of the LytR AlgR family
HUW48_23875	COG3275	phosphorelay sensor kinase activity
HUW48_23890	COG4251	negative regulation of phosphorylation
HUW48_23895	COG2201	protein-glutamate methylesterase activity
HUW48_23910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW48_23925	COG4771	TonB-dependent receptor
HUW48_23935	COG0251	oxidation-reduction process
HUW48_23970	COG4771	TonB-dependent receptor
HUW48_23985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_23995	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW48_24005	COG1309	transcriptional regulator
HUW48_24010	COG4335	DNA alkylation repair
HUW48_24085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_24145	COG1132	(ABC) transporter
HUW48_24160	COG3387	PFAM Glycoside hydrolase 15-related
HUW48_24185	COG0673	inositol 2-dehydrogenase activity
HUW48_24210	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_24215	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUW48_24220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW48_24235	COG0483	inositol monophosphate 1-phosphatase activity
HUW48_24255	COG0668	transmembrane transport
HUW48_24270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW48_24280	COG2814	Major facilitator Superfamily
HUW48_24300	COG0596	Alpha beta hydrolase
HUW48_24310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW48_24315	COG0805	protein transport
HUW48_24320	COG0698	ribose 5-phosphate isomerase
HUW48_24330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW48_24340	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUW48_24345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW48_24355	COG1233	COG1233 Phytoene dehydrogenase and related
HUW48_24370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW48_24395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUW48_24415	COG1629	transport
HUW48_24415	COG4206	TonB-dependent receptor
HUW48_24420	COG0384	phenazine biosynthesis protein PhzF
HUW48_24430	COG0730	response to heat
HUW48_24435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_24455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUW48_24485	COG2226	methyltransferase
HUW48_24525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_24550	COG1137	ATPase activity
HUW48_24575	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUW48_24575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUW48_24595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW48_24605	COG0297	glycogen (starch) synthase activity
HUW48_24610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUW48_24615	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUW48_24625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW48_24625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW48_24635	COG1960	acyl-CoA dehydrogenase activity
HUW48_24645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HUW48_24660	COG0484	heat shock protein binding
HUW48_24665	COG0753	catalase activity
HUW48_24720	COG1301	dicarboxylic acid transport
HUW48_24750	COG0584	glycerophosphoryl diester phosphodiesterase
HUW48_24755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUW48_24820	COG2197	response regulator
HUW48_24845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUW48_24855	COG3104	oligopeptide transport
HUW48_24865	COG0517	IMP dehydrogenase activity
HUW48_24865	COG0516	GMP reductase activity
HUW48_24870	COG4628	conserved protein (DUF2132)
HUW48_24895	COG1643	Atp-dependent helicase
HUW48_24900	COG4989	oxidoreductase activity
HUW48_24905	COG1187	pseudouridine synthase activity
HUW48_24955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_24960	COG1040	competence protein
HUW48_24975	COG0708	Exodeoxyribonuclease III
HUW48_24990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW48_24995	COG0445	tRNA wobble uridine modification
HUW48_25020	COG0306	phosphate transporter
HUW48_25025	COG0423	glycine-tRNA ligase activity
HUW48_25035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUW48_25040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUW48_25045	COG4172	Belongs to the ABC transporter superfamily
HUW48_25050	COG0557	exoribonuclease II activity
HUW48_25055	COG0142	geranyltranstransferase activity
HUW48_25090	COG3685	Protein conserved in bacteria
HUW48_25095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_25100	COG0217	transcriptional regulatory protein
HUW48_25105	COG0586	Pfam SNARE associated Golgi protein
HUW48_25120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW48_25125	COG1051	belongs to the nudix hydrolase family
HUW48_25135	COG2234	aminopeptidase activity
HUW48_25155	COG0436	Aminotransferase
HUW48_25160	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_25185	COG5002	protein histidine kinase activity
HUW48_25185	COG0784	Response regulator, receiver
HUW48_25190	COG2204	response regulator
HUW48_25205	COG2183	response to ionizing radiation
HUW48_25220	COG0477	Major facilitator Superfamily
HUW48_25235	COG2124	cytochrome p450
HUW48_25245	COG0673	inositol 2-dehydrogenase activity
HUW48_25255	COG0657	acetylesterase activity
HUW48_25255	COG2755	lipolytic protein G-D-S-L family
HUW48_25260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUW48_25270	COG0367	asparagine synthase
HUW48_25275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW48_25285	COG1595	DNA-templated transcription, initiation
HUW48_25335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_25370	COG1607	acyl-coa hydrolase
HUW48_25380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW48_25385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUW48_25395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUW48_25410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUW48_25415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW48_25420	COG1187	pseudouridine synthase activity
HUW48_25425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUW48_25450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW48_25465	COG2211	Major facilitator Superfamily
HUW48_25480	COG0673	inositol 2-dehydrogenase activity
HUW48_25510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW48_25550	COG4206	TonB-dependent receptor
HUW48_25550	COG1629	transport
HUW48_25565	COG2723	6-phospho-beta-galactosidase activity
HUW48_25580	COG1595	DNA-templated transcription, initiation
HUW48_25640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW48_25675	COG1136	(ABC) transporter
HUW48_25675	COG0577	efflux transmembrane transporter activity
HUW48_25680	COG0577	efflux transmembrane transporter activity
HUW48_25700	COG1136	(ABC) transporter
HUW48_25700	COG0577	efflux transmembrane transporter activity
HUW48_25715	COG0577	efflux transmembrane transporter activity
HUW48_25720	COG1136	(ABC) transporter
HUW48_25720	COG0577	efflux transmembrane transporter activity
HUW48_25735	COG0492	ferredoxin-NADP+ reductase activity
HUW48_25745	COG2226	methyltransferase
HUW48_25750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW48_25785	COG4771	TonB-dependent receptor
HUW48_25790	COG0702	epimerase
HUW48_25810	COG0346	lactoylglutathione lyase activity
HUW48_25825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW48_25825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW48_25830	COG0745	RESPONSE REGULATOR receiver
HUW48_25835	COG2205	protein histidine kinase activity
HUW48_25855	COG0673	inositol 2-dehydrogenase activity
HUW48_25860	COG0688	phosphatidylethanolamine metabolic process
HUW48_25865	COG1956	GAF domain-containing protein
HUW48_25870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW48_25870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW48_25875	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW48_25885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUW48_25890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW48_25900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_25905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUW48_25910	COG1228	amidohydrolase
HUW48_25920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUW48_25955	COG1215	transferase activity, transferring glycosyl groups
HUW48_25965	COG1132	(ABC) transporter
HUW48_25990	COG0589	response to stress
HUW48_25990	COG0475	glutathione-regulated potassium exporter activity
HUW48_26015	COG0673	inositol 2-dehydrogenase activity
HUW48_26025	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_26070	COG0513	Belongs to the DEAD box helicase family
HUW48_26075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW48_26105	COG2329	Antibiotic biosynthesis monooxygenase
HUW48_26120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW48_26125	COG0594	ribonuclease P activity
HUW48_26175	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_26190	COG2271	Major facilitator Superfamily
HUW48_26195	COG4206	TonB-dependent receptor
HUW48_26195	COG1629	transport
HUW48_26265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW48_26275	COG4974	Belongs to the 'phage' integrase family
HUW48_26280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW48_26285	COG1960	acyl-CoA dehydrogenase activity
HUW48_26305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_26315	COG1809	phosphosulfolactate synthase activity
HUW48_26320	COG0586	Pfam SNARE associated Golgi protein
HUW48_26325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW48_26360	COG0556	nucleotide-excision repair
HUW48_26390	COG0583	DNA-binding transcription factor activity
HUW48_26395	COG4106	trans-aconitate 2-methyltransferase activity
HUW48_26420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW48_26420	COG1648	precorrin-2 dehydrogenase activity
HUW48_26425	COG0673	inositol 2-dehydrogenase activity
HUW48_26440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW48_26485	COG0726	polysaccharide deacetylase
HUW48_26490	COG1215	transferase activity, transferring glycosyl groups
HUW48_26495	COG0084	hydrolase, TatD family'
HUW48_26500	COG0252	asparaginase activity
HUW48_26520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_26565	COG0546	phosphoglycolate phosphatase activity
HUW48_26595	COG0577	efflux transmembrane transporter activity
HUW48_26595	COG1136	(ABC) transporter
HUW48_26605	COG2204	response regulator
HUW48_26610	COG5002	protein histidine kinase activity
HUW48_26610	COG3850	Histidine kinase
HUW48_26630	COG4953	penicillin-binding protein 1C
HUW48_26640	COG0488	(ABC) transporter
HUW48_26650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis