locus-tag	class	description
HUW51_00050	COG1196	nuclear chromosome segregation
HUW51_00050	COG0741	lytic transglycosylase activity
HUW51_00050	COG0739	heme binding
HUW51_00105	COG0671	phosphoesterase, PA-phosphatase related
HUW51_00115	COG0148	phosphopyruvate hydratase activity
HUW51_00120	COG0038	chloride channel
HUW51_00130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW51_00140	COG0671	phosphoesterase, PA-phosphatase related
HUW51_00145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_00170	COG0745	RESPONSE REGULATOR receiver
HUW51_00175	COG0671	phosphoesterase, PA-phosphatase related
HUW51_00220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW51_00315	COG1064	alcohol dehydrogenase
HUW51_00340	COG0300	oxidoreductase activity
HUW51_00365	COG4804	nuclease activity
HUW51_00455	COG0798	PFAM Bile acid sodium symporter
HUW51_00465	COG1742	UPF0060 membrane protein
HUW51_00470	COG0671	phosphoesterase, PA-phosphatase related
HUW51_00475	COG2217	Heavy metal translocating P-type atpase
HUW51_00510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_00540	COG2207	Transcriptional regulator
HUW51_00585	COG2217	Heavy metal translocating P-type atpase
HUW51_00615	COG1192	Involved in chromosome partitioning
HUW51_00620	COG4227	nucleotidyltransferase activity
HUW51_00680	COG1201	RNA secondary structure unwinding
HUW51_00710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW51_00780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW51_00785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW51_00815	COG0587	DNA-directed DNA polymerase activity
HUW51_00820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_00825	COG2135	peptidase activity
HUW51_00855	COG2003	Belongs to the UPF0758 family
HUW51_00965	COG0739	heme binding
HUW51_00965	COG1196	nuclear chromosome segregation
HUW51_00965	COG0741	lytic transglycosylase activity
HUW51_01025	COG3239	Fatty acid desaturase
HUW51_01030	COG1278	Cold shock
HUW51_01035	COG1595	DNA-templated transcription, initiation
HUW51_01120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_01125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW51_01130	COG2080	2 iron, 2 sulfur cluster binding
HUW51_01145	COG0702	epimerase
HUW51_01150	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_01170	COG0110	maltose O-acetyltransferase activity
HUW51_01190	COG0028	Belongs to the TPP enzyme family
HUW51_01195	COG1733	regulation of RNA biosynthetic process
HUW51_01205	COG3547	Transposase (IS116 IS110 IS902 family)
HUW51_01215	COG0577	efflux transmembrane transporter activity
HUW51_01250	COG1388	LysM domain
HUW51_01250	COG4932	domain protein
HUW51_01265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUW51_01275	COG1597	lipid kinase activity
HUW51_01285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUW51_01320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW51_01325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW51_01340	COG1053	succinate dehydrogenase
HUW51_01350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUW51_01360	COG0791	NLP P60 protein
HUW51_01360	COG3103	Sh3 type 3 domain protein
HUW51_01360	COG1388	LysM domain
HUW51_01375	COG3851	Histidine kinase
HUW51_01390	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_01400	COG3118	belongs to the thioredoxin family
HUW51_01415	COG0302	gtp cyclohydrolase
HUW51_01420	COG1090	epimerase
HUW51_01430	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_01480	COG4771	TonB-dependent receptor
HUW51_01515	COG1629	transport
HUW51_01520	COG1629	transport
HUW51_01530	COG1595	DNA-templated transcription, initiation
HUW51_01540	COG1760	l-serine dehydratase
HUW51_01575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW51_01590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW51_01600	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW51_01605	COG0740	serine-type endopeptidase activity
HUW51_01615	COG1401	restriction endodeoxyribonuclease activity
HUW51_01620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW51_01625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW51_01640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_01650	COG2814	Major facilitator Superfamily
HUW51_01670	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_01685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW51_01690	COG0513	Belongs to the DEAD box helicase family
HUW51_01735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_01795	COG0673	inositol 2-dehydrogenase activity
HUW51_01860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_01900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW51_01910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW51_01935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUW51_01945	COG3844	kynureninase activity
HUW51_01950	COG3757	hydrolase, family 25
HUW51_01970	COG2514	catechol 2,3-dioxygenase activity
HUW51_02010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_02035	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW51_02050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW51_02060	COG1253	flavin adenine dinucleotide binding
HUW51_02075	COG3046	protein related to deoxyribodipyrimidine photolyase
HUW51_02085	COG2223	nitrite transmembrane transporter activity
HUW51_02090	COG1943	Transposase
HUW51_02095	COG2318	DinB family
HUW51_02135	COG2259	Doxx family
HUW51_02140	COG0531	amino acid
HUW51_02160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW51_02185	COG3118	belongs to the thioredoxin family
HUW51_02190	COG4251	negative regulation of phosphorylation
HUW51_02195	COG3279	Response regulator of the LytR AlgR family
HUW51_02200	COG4191	Histidine kinase
HUW51_02205	COG2204	response regulator
HUW51_02265	COG0070	glutamate synthase
HUW51_02265	COG0069	glutamate synthase activity
HUW51_02265	COG0067	glutamate synthase
HUW51_02270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUW51_02275	COG0616	signal peptide processing
HUW51_02280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW51_02285	COG3876	Protein conserved in bacteria
HUW51_02295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW51_02310	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_02320	COG1136	(ABC) transporter
HUW51_02340	COG0700	Nucleoside recognition
HUW51_02345	COG2027	D-alanyl-D-alanine carboxypeptidase
HUW51_02350	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_02355	COG0564	pseudouridine synthase activity
HUW51_02360	COG5002	protein histidine kinase activity
HUW51_02365	COG0745	RESPONSE REGULATOR receiver
HUW51_02375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW51_02400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW51_02405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_02410	COG1741	Belongs to the pirin family
HUW51_02415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW51_02420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW51_02425	COG0577	efflux transmembrane transporter activity
HUW51_02425	COG1136	(ABC) transporter
HUW51_02430	COG1611	Belongs to the LOG family
HUW51_02440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW51_02455	COG1024	Enoyl-CoA hydratase
HUW51_02465	COG0017	Asparaginyl-tRNA synthetase
HUW51_02485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW51_02525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUW51_02550	COG1446	asparaginase
HUW51_02565	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_02570	COG4993	Dehydrogenase
HUW51_02605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW51_02615	COG0861	Integral membrane protein TerC family
HUW51_02620	COG1666	GTP binding
HUW51_02625	COG3040	lipid binding
HUW51_02640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW51_02650	COG0436	Aminotransferase
HUW51_02655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_02670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW51_02685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW51_02695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW51_02725	COG4636	protein conserved in cyanobacteria
HUW51_02735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW51_02750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUW51_02760	COG1970	mechanosensitive ion channel activity
HUW51_02765	COG1024	Enoyl-CoA hydratase
HUW51_02775	COG0756	dUTP diphosphatase activity
HUW51_02800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW51_02805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW51_02810	COG0154	amidase activity
HUW51_02820	COG0280	phosphate acetyltransferase
HUW51_02820	COG0281	malic enzyme
HUW51_02825	COG0632	four-way junction helicase activity
HUW51_02835	COG0509	glycine decarboxylation via glycine cleavage system
HUW51_02845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_02850	COG1561	YicC-like family, N-terminal region
HUW51_02860	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW51_02875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_02880	COG1183	phosphatidylcholine synthase activity
HUW51_02930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW51_02940	COG3118	belongs to the thioredoxin family
HUW51_02955	COG0022	dehydrogenase e1 component
HUW51_02960	COG4771	TonB-dependent receptor
HUW51_02965	COG0612	Peptidase, M16
HUW51_02975	COG0667	Aldo Keto reductase
HUW51_03025	COG0488	(ABC) transporter
HUW51_03040	COG1121	(ABC) transporter
HUW51_03045	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_03070	COG2814	Major facilitator Superfamily
HUW51_03085	COG0300	oxidoreductase activity
HUW51_03090	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_03095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_03100	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW51_03110	COG1473	amidohydrolase
HUW51_03120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUW51_03125	COG0653	protein targeting
HUW51_03135	COG0116	Belongs to the methyltransferase superfamily
HUW51_03135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW51_03140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW51_03180	COG0148	phosphopyruvate hydratase activity
HUW51_03185	COG0505	Belongs to the CarA family
HUW51_03190	COG0203	ribosomal protein L17
HUW51_03195	COG0202	RNA polymerase activity
HUW51_03200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW51_03205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW51_03210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW51_03215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW51_03220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW51_03225	COG0024	Methionine aminopeptidase
HUW51_03230	COG0201	protein transport
HUW51_03235	COG0200	Binds to the 23S rRNA
HUW51_03240	COG1841	ribosomal large subunit assembly
HUW51_03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW51_03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW51_03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW51_03260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW51_03265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW51_03275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW51_03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW51_03285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUW51_03290	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW51_03295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW51_03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW51_03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW51_03310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW51_03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW51_03320	COG0089	rRNA binding
HUW51_03325	COG0088	Forms part of the polypeptide exit tunnel
HUW51_03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW51_03335	COG0051	transcription antitermination factor activity, RNA binding
HUW51_03340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW51_03345	COG0049	tRNA binding
HUW51_03350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW51_03360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUW51_03365	COG0085	RNA polymerase activity
HUW51_03370	COG0222	ribosome binding
HUW51_03375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW51_03380	COG0081	regulation of translation
HUW51_03385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW51_03425	COG0308	aminopeptidase N
HUW51_03430	COG0511	ligase activity, forming carbon-carbon bonds
HUW51_03435	COG0528	UMP kinase activity
HUW51_03440	COG0233	cytoplasmic translational termination
HUW51_03445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUW51_03470	COG0191	fructose-bisphosphate aldolase activity
HUW51_03480	COG0004	ammonium transporteR
HUW51_03485	COG0788	formyltetrahydrofolate deformylase activity
HUW51_03500	COG3142	Participates in the control of copper homeostasis
HUW51_03515	COG1428	Deoxynucleoside kinase
HUW51_03530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW51_03535	COG0194	GDP metabolic process
HUW51_03545	COG1595	DNA-templated transcription, initiation
HUW51_03560	COG0463	Glycosyl transferase, family 2
HUW51_03565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW51_03605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_03615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_03635	COG1309	transcriptional regulator
HUW51_03640	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_03645	COG2353	YceI-like domain
HUW51_03665	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_03670	COG1301	dicarboxylic acid transport
HUW51_03680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_03695	COG1546	Belongs to the CinA family
HUW51_03695	COG1058	Belongs to the CinA family
HUW51_03715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_03720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW51_03725	COG1132	(ABC) transporter
HUW51_03735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUW51_03745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW51_03750	COG2885	chlorophyll binding
HUW51_03760	COG0750	zinc metalloprotease
HUW51_03765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUW51_03775	COG1764	response to oxidative stress
HUW51_03785	COG0730	response to heat
HUW51_03790	COG0450	alkyl hydroperoxide reductase
HUW51_03805	COG1959	2 iron, 2 sulfur cluster binding
HUW51_03810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW51_03815	COG0737	Belongs to the 5'-nucleotidase family
HUW51_03820	COG0737	Belongs to the 5'-nucleotidase family
HUW51_03835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_03845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_03845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_03860	COG5642	Protein of unknown function (DUF2384)
HUW51_03865	COG5654	RES domain protein
HUW51_03890	COG0778	Nitroreductase
HUW51_03905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUW51_03915	COG2319	Wd-40 repeat
HUW51_03920	COG2091	lysine biosynthetic process via aminoadipic acid
HUW51_03930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW51_03930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW51_03935	COG0436	Aminotransferase
HUW51_03945	COG2502	aspartate--ammonia ligase
HUW51_03950	COG0667	Aldo Keto reductase
HUW51_03965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW51_03985	COG1215	transferase activity, transferring glycosyl groups
HUW51_03995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUW51_04030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW51_04035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW51_04050	COG0525	valine-tRNA ligase activity
HUW51_04065	COG2204	response regulator
HUW51_04085	COG1136	(ABC) transporter
HUW51_04100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_04105	COG1058	Belongs to the CinA family
HUW51_04105	COG1546	Belongs to the CinA family
HUW51_04135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_04140	COG1217	gtp-binding protein TYPA
HUW51_04155	COG4773	Receptor
HUW51_04165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUW51_04180	COG2314	TM2 domain
HUW51_04185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW51_04190	COG5002	protein histidine kinase activity
HUW51_04205	COG0531	amino acid
HUW51_04220	COG2197	response regulator
HUW51_04225	COG1528	Iron-storage protein
HUW51_04245	COG2252	PERMEase
HUW51_04260	COG3250	beta-galactosidase activity
HUW51_04265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_04270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_04290	COG2353	YceI-like domain
HUW51_04315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW51_04325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW51_04345	COG0612	Peptidase, M16
HUW51_04350	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUW51_04365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW51_04430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUW51_04455	COG0463	Glycosyl transferase, family 2
HUW51_04505	COG0149	triose-phosphate isomerase activity
HUW51_04515	COG2264	protein methyltransferase activity
HUW51_04525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW51_04570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW51_04575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW51_04605	COG0702	epimerase
HUW51_04645	COG0300	oxidoreductase activity
HUW51_04650	COG0667	Aldo Keto reductase
HUW51_04655	COG1902	pentaerythritol trinitrate reductase activity
HUW51_04660	COG1846	Transcriptional regulator
HUW51_04670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW51_04675	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HUW51_04680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_04685	COG0552	protein localization to endoplasmic reticulum
HUW51_04695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW51_04700	COG1215	transferase activity, transferring glycosyl groups
HUW51_04705	COG0006	proline dipeptidase activity
HUW51_04710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW51_04720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW51_04735	COG0113	porphobilinogen synthase activity
HUW51_04740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_04745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW51_04745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUW51_04750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_04755	COG4133	protoheme IX ABC transporter activity
HUW51_04765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_04765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_04785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_04795	COG0540	Belongs to the ATCase OTCase family
HUW51_04800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW51_04820	COG1796	DNA polymerase
HUW51_04820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW51_04845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW51_04850	COG0601	transmembrane transport
HUW51_04865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW51_04870	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUW51_04895	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_04905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_04920	COG4771	TonB-dependent receptor
HUW51_04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_04950	COG3275	phosphorelay sensor kinase activity
HUW51_04955	COG3279	Response regulator of the LytR AlgR family
HUW51_04990	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_04995	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_05000	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_05010	COG1629	transport
HUW51_05140	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_05150	COG0159	tryptophan synthase activity
HUW51_05155	COG0133	tryptophan synthase activity
HUW51_05160	COG0135	phosphoribosylanthranilate isomerase activity
HUW51_05165	COG0134	indole-3-glycerol-phosphate synthase activity
HUW51_05170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW51_05175	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW51_05175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW51_05185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW51_05195	COG0366	Alpha amylase catalytic
HUW51_05240	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUW51_05250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_05270	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_05275	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW51_05280	COG2205	protein histidine kinase activity
HUW51_05280	COG0784	Response regulator, receiver
HUW51_05290	COG3618	amidohydrolase
HUW51_05305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_05315	COG0596	Alpha beta hydrolase
HUW51_05320	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_05325	COG1940	carbohydrate kinase activity
HUW51_05325	COG1846	Transcriptional regulator
HUW51_05330	COG2706	6-phosphogluconolactonase activity
HUW51_05335	COG2084	Dehydrogenase
HUW51_05370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_05380	COG1629	transport
HUW51_05385	COG0702	epimerase
HUW51_05390	COG3119	arylsulfatase activity
HUW51_05395	COG3408	Glycogen debranching enzyme
HUW51_05395	COG3119	arylsulfatase activity
HUW51_05455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW51_05460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW51_05465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_05495	COG1725	Transcriptional regulator
HUW51_05510	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_05520	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_05540	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_05550	COG3059	membrane
HUW51_05555	COG2207	Transcriptional regulator
HUW51_05555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_05565	COG4335	DNA alkylation repair
HUW51_05570	COG0697	spore germination
HUW51_05580	COG2197	response regulator
HUW51_05585	COG4771	TonB-dependent receptor
HUW51_05635	COG1629	transport
HUW51_05680	COG4251	negative regulation of phosphorylation
HUW51_05690	COG2172	sigma factor antagonist activity
HUW51_05695	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW51_05700	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW51_05705	COG4251	negative regulation of phosphorylation
HUW51_05725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW51_05735	COG4804	nuclease activity
HUW51_05760	COG4677	pectinesterase activity
HUW51_05765	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_05770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUW51_05800	COG1629	transport
HUW51_05835	COG5564	TIM-barrel signal transduction protein
HUW51_05845	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_05855	COG1070	Carbohydrate kinase
HUW51_05860	COG1070	Carbohydrate kinase
HUW51_05865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_05870	COG2814	Major facilitator Superfamily
HUW51_05875	COG0702	epimerase
HUW51_05880	COG1629	transport
HUW51_05885	COG1349	DNA-binding transcription factor activity
HUW51_05890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_05900	COG0657	acetylesterase activity
HUW51_05900	COG2755	lipolytic protein G-D-S-L family
HUW51_05910	COG2271	Major facilitator Superfamily
HUW51_05920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW51_05925	COG0702	epimerase
HUW51_05930	COG4771	TonB-dependent receptor
HUW51_05935	COG2186	Transcriptional regulator
HUW51_05950	COG1278	Cold shock
HUW51_05965	COG1774	PSP1 C-terminal conserved region
HUW51_05985	COG1556	Lactate utilization protein
HUW51_05990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW51_05995	COG0799	negative regulation of ribosome biogenesis
HUW51_06020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW51_06025	COG0612	Peptidase, M16
HUW51_06030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW51_06045	COG1596	polysaccharide export
HUW51_06045	COG1555	photosystem II stabilization
HUW51_06065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUW51_06070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_06075	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW51_06085	COG0297	glycogen (starch) synthase activity
HUW51_06105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW51_06130	COG0438	transferase activity, transferring glycosyl groups
HUW51_06135	COG0438	transferase activity, transferring glycosyl groups
HUW51_06140	COG1216	Glycosyl transferase, family 2
HUW51_06180	COG0492	ferredoxin-NADP+ reductase activity
HUW51_06190	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW51_06200	COG1215	transferase activity, transferring glycosyl groups
HUW51_06205	COG5002	protein histidine kinase activity
HUW51_06205	COG2198	Histidine kinase
HUW51_06205	COG0784	Response regulator, receiver
HUW51_06210	COG0745	RESPONSE REGULATOR receiver
HUW51_06215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW51_06235	COG1216	Glycosyl transferase, family 2
HUW51_06235	COG0463	Glycosyl transferase, family 2
HUW51_06245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW51_06245	COG2755	lipolytic protein G-D-S-L family
HUW51_06255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_06290	COG3123	guanosine phosphorylase activity
HUW51_06305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUW51_06310	COG4654	Cytochrome c, class I
HUW51_06325	COG0612	Peptidase, M16
HUW51_06330	COG0438	transferase activity, transferring glycosyl groups
HUW51_06335	COG0006	proline dipeptidase activity
HUW51_06340	COG2885	chlorophyll binding
HUW51_06360	COG0419	ATPase involved in DNA repair
HUW51_06365	COG0420	3'-5' exonuclease activity
HUW51_06370	COG2201	protein-glutamate methylesterase activity
HUW51_06375	COG0039	L-malate dehydrogenase activity
HUW51_06380	COG0037	tRNA processing
HUW51_06415	COG0497	DNA recombination
HUW51_06420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUW51_06425	COG0662	Cupin 2, conserved barrel domain protein
HUW51_06425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW51_06445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW51_06535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_06540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_06545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_06550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_06555	COG0649	NAD binding
HUW51_06560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW51_06560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW51_06575	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HUW51_06580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW51_06585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW51_06590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW51_06595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW51_06600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW51_06605	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW51_06630	COG0322	excinuclease ABC activity
HUW51_06635	COG1289	transmembrane transporter activity
HUW51_06655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_06675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW51_06685	COG0321	lipoyl(octanoyl) transferase activity
HUW51_06690	COG0166	Belongs to the GPI family
HUW51_06695	COG0792	nuclease activity
HUW51_06730	COG1505	serine-type exopeptidase activity
HUW51_06755	COG2852	Protein conserved in bacteria
HUW51_06775	COG1704	LemA family
HUW51_06820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW51_06820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW51_06830	COG2223	nitrite transmembrane transporter activity
HUW51_06845	COG4864	UPF0365 protein
HUW51_06860	COG0662	Cupin 2, conserved barrel domain protein
HUW51_06870	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_06900	COG0442	prolyl-tRNA aminoacylation
HUW51_06905	COG0673	inositol 2-dehydrogenase activity
HUW51_06910	COG1085	galactose-1-phosphate uridylyltransferase
HUW51_06915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW51_06925	COG4654	Cytochrome c, class I
HUW51_06930	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_06935	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_06940	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW51_06970	COG4771	TonB-dependent receptor
HUW51_07005	COG0793	Belongs to the peptidase S41A family
HUW51_07025	COG3047	cAMP biosynthetic process
HUW51_07025	COG2885	chlorophyll binding
HUW51_07040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUW51_07050	COG4181	ATPase activity
HUW51_07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW51_07060	COG2198	Histidine kinase
HUW51_07060	COG0784	Response regulator, receiver
HUW51_07060	COG2205	protein histidine kinase activity
HUW51_07070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW51_07075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUW51_07080	COG0440	acetolactate synthase activity
HUW51_07085	COG0028	Belongs to the TPP enzyme family
HUW51_07095	COG0129	dihydroxy-acid dehydratase activity
HUW51_07100	COG0460	homoserine dehydrogenase
HUW51_07100	COG0527	aspartate kinase activity
HUW51_07105	COG0083	homoserine kinase activity
HUW51_07110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW51_07115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW51_07120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW51_07125	COG0066	3-isopropylmalate dehydratase activity
HUW51_07165	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_07175	COG3158	transport of potassium into the cell
HUW51_07195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_07205	COG2205	protein histidine kinase activity
HUW51_07205	COG0784	Response regulator, receiver
HUW51_07220	COG0673	inositol 2-dehydrogenase activity
HUW51_07230	COG2755	lipolytic protein G-D-S-L family
HUW51_07230	COG0657	acetylesterase activity
HUW51_07290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_07330	COG1607	acyl-coa hydrolase
HUW51_07340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW51_07345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUW51_07355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUW51_07370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUW51_07375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW51_07380	COG1187	pseudouridine synthase activity
HUW51_07385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUW51_07405	COG1253	flavin adenine dinucleotide binding
HUW51_07410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_07420	COG5002	protein histidine kinase activity
HUW51_07425	COG0745	RESPONSE REGULATOR receiver
HUW51_07430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW51_07430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW51_07445	COG0346	lactoylglutathione lyase activity
HUW51_07455	COG1137	ATPase activity
HUW51_07475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUW51_07475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUW51_07480	COG1295	ribonuclease BN
HUW51_07485	COG0251	oxidation-reduction process
HUW51_07490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW51_07500	COG0297	glycogen (starch) synthase activity
HUW51_07505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUW51_07510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUW51_07520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW51_07520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW51_07530	COG1960	acyl-CoA dehydrogenase activity
HUW51_07540	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HUW51_07555	COG0484	heat shock protein binding
HUW51_07560	COG0753	catalase activity
HUW51_07575	COG3781	membrane
HUW51_07590	COG2181	nitrate reductase activity
HUW51_07590	COG0247	lactate metabolic process
HUW51_07595	COG2181	nitrate reductase activity
HUW51_07595	COG0247	lactate metabolic process
HUW51_07605	COG2885	chlorophyll binding
HUW51_07610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW51_07625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW51_07630	COG0805	protein transport
HUW51_07645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW51_07655	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUW51_07660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW51_07670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW51_07690	COG0577	efflux transmembrane transporter activity
HUW51_07690	COG1136	(ABC) transporter
HUW51_07700	COG1136	(ABC) transporter
HUW51_07700	COG0577	efflux transmembrane transporter activity
HUW51_07730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW51_07755	COG0577	efflux transmembrane transporter activity
HUW51_07760	COG0577	efflux transmembrane transporter activity
HUW51_07770	COG0577	efflux transmembrane transporter activity
HUW51_07770	COG1136	(ABC) transporter
HUW51_07785	COG0477	Major facilitator Superfamily
HUW51_07800	COG2183	response to ionizing radiation
HUW51_07815	COG2204	response regulator
HUW51_07820	COG0784	Response regulator, receiver
HUW51_07820	COG5002	protein histidine kinase activity
HUW51_07850	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_07855	COG0436	Aminotransferase
HUW51_07860	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_07870	COG2234	aminopeptidase activity
HUW51_07875	COG1051	belongs to the nudix hydrolase family
HUW51_07880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW51_07905	COG0586	Pfam SNARE associated Golgi protein
HUW51_07915	COG0217	transcriptional regulatory protein
HUW51_07925	COG3685	Protein conserved in bacteria
HUW51_07945	COG0705	Rhomboid family
HUW51_07950	COG0142	geranyltranstransferase activity
HUW51_07955	COG0557	exoribonuclease II activity
HUW51_07965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUW51_07970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUW51_07980	COG0423	glycine-tRNA ligase activity
HUW51_07985	COG0306	phosphate transporter
HUW51_08010	COG0445	tRNA wobble uridine modification
HUW51_08015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW51_08030	COG0708	Exodeoxyribonuclease III
HUW51_08045	COG1040	competence protein
HUW51_08050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_08090	COG1187	pseudouridine synthase activity
HUW51_08095	COG4989	oxidoreductase activity
HUW51_08100	COG1643	Atp-dependent helicase
HUW51_08120	COG4628	conserved protein (DUF2132)
HUW51_08125	COG2239	Acts as a magnesium transporter
HUW51_08140	COG3104	oligopeptide transport
HUW51_08150	COG5265	(ABC) transporter
HUW51_08200	COG2814	Major facilitator Superfamily
HUW51_08210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW51_08225	COG0668	transmembrane transport
HUW51_08245	COG0483	inositol monophosphate 1-phosphatase activity
HUW51_08260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW51_08265	COG2304	oxidoreductase activity
HUW51_08285	COG2255	four-way junction helicase activity
HUW51_08305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW51_08310	COG0346	lactoylglutathione lyase activity
HUW51_08315	COG1473	amidohydrolase
HUW51_08325	COG0527	aspartate kinase activity
HUW51_08335	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_08335	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_08360	COG0673	inositol 2-dehydrogenase activity
HUW51_08405	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_08420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW51_08425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW51_08465	COG4895	conserved protein (DUF2196)
HUW51_08485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_08500	COG0590	tRNA wobble adenosine to inosine editing
HUW51_08505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW51_08550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUW51_08570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_08575	COG0730	response to heat
HUW51_08585	COG0384	phenazine biosynthesis protein PhzF
HUW51_08595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW51_08620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUW51_08640	COG1629	transport
HUW51_08640	COG4206	TonB-dependent receptor
HUW51_08650	COG1233	COG1233 Phytoene dehydrogenase and related
HUW51_08660	COG0577	efflux transmembrane transporter activity
HUW51_08665	COG0577	efflux transmembrane transporter activity
HUW51_08715	COG1629	transport
HUW51_08720	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_08730	COG4206	TonB-dependent receptor
HUW51_08730	COG1629	transport
HUW51_08740	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_08745	COG1609	Transcriptional regulator
HUW51_08750	COG3734	2-keto-3-deoxy-galactonokinase
HUW51_08755	COG0800	Aldolase
HUW51_08785	COG0702	epimerase
HUW51_08790	COG4771	TonB-dependent receptor
HUW51_08810	COG0352	thiamine-phosphate diphosphorylase activity
HUW51_08815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW51_08820	COG2226	methyltransferase
HUW51_08835	COG1309	transcriptional regulator
HUW51_08850	COG4221	oxidoreductase activity
HUW51_08855	COG1794	racemase activity, acting on amino acids and derivatives
HUW51_08860	COG1733	regulation of RNA biosynthetic process
HUW51_08865	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUW51_08870	COG1733	regulation of RNA biosynthetic process
HUW51_08875	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_08920	COG0577	efflux transmembrane transporter activity
HUW51_08925	COG0577	efflux transmembrane transporter activity
HUW51_08955	COG0577	efflux transmembrane transporter activity
HUW51_08955	COG1136	(ABC) transporter
HUW51_08970	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_09010	COG1609	Transcriptional regulator
HUW51_09015	COG4771	TonB-dependent receptor
HUW51_09020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HUW51_09025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_09110	COG2323	membrane
HUW51_09120	COG2353	YceI-like domain
HUW51_09155	COG1595	DNA-templated transcription, initiation
HUW51_09160	COG2852	Protein conserved in bacteria
HUW51_09165	COG2723	6-phospho-beta-galactosidase activity
HUW51_09180	COG4206	TonB-dependent receptor
HUW51_09180	COG1629	transport
HUW51_09215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW51_09240	COG0673	inositol 2-dehydrogenase activity
HUW51_09260	COG2211	Major facilitator Superfamily
HUW51_09290	COG0714	Associated with various cellular activities
HUW51_09305	COG2226	methyltransferase
HUW51_09310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUW51_09345	COG1138	Cytochrome C-type biogenesis protein
HUW51_09355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUW51_09360	COG1278	Cold shock
HUW51_09370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUW51_09375	COG0138	bifunctional purine biosynthesis protein purh
HUW51_09380	COG1077	Cell shape determining protein MreB Mrl
HUW51_09395	COG0768	penicillin binding
HUW51_09400	COG0772	Belongs to the SEDS family
HUW51_09415	COG1435	thymidine kinase activity
HUW51_09430	COG1381	Involved in DNA repair and RecF pathway recombination
HUW51_09440	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_09445	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_09450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW51_09455	COG0105	UTP biosynthetic process
HUW51_09470	COG5180	pathogenesis
HUW51_09470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW51_09475	COG0195	Participates in both transcription termination and antitermination
HUW51_09490	COG0215	cysteine-tRNA ligase activity
HUW51_09495	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUW51_09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW51_09510	COG2873	o-acetylhomoserine
HUW51_09515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW51_09540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW51_09545	COG1522	sequence-specific DNA binding
HUW51_09575	COG4771	TonB-dependent receptor
HUW51_09600	COG3254	rhamnose metabolic process
HUW51_09610	COG1063	alcohol dehydrogenase
HUW51_09615	COG0667	Aldo Keto reductase
HUW51_09620	COG1063	alcohol dehydrogenase
HUW51_09625	COG1082	Xylose isomerase domain protein TIM barrel
HUW51_09630	COG3254	rhamnose metabolic process
HUW51_09675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUW51_09700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW51_09715	COG0612	Peptidase, M16
HUW51_09735	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_09790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_09805	COG2197	response regulator
HUW51_09825	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW51_09835	COG0004	ammonium transporteR
HUW51_09845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW51_09850	COG0248	Ppx GppA phosphatase
HUW51_09855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW51_09860	COG0247	lactate metabolic process
HUW51_09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW51_09870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW51_09905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_09925	COG2329	Antibiotic biosynthesis monooxygenase
HUW51_09940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW51_09945	COG0594	ribonuclease P activity
HUW51_09950	COG0793	Belongs to the peptidase S41A family
HUW51_09995	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_10010	COG2271	Major facilitator Superfamily
HUW51_10030	COG1629	transport
HUW51_10060	COG1301	dicarboxylic acid transport
HUW51_10070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUW51_10125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUW51_10195	COG1858	cytochrome C peroxidase
HUW51_10215	COG0656	L-ascorbic acid biosynthetic process
HUW51_10220	COG0667	Aldo Keto reductase
HUW51_10260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_10260	COG2010	Cytochrome c
HUW51_10295	COG0464	growth
HUW51_10310	COG0626	cystathionine gamma-synthase activity
HUW51_10320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW51_10350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUW51_10370	COG1605	Chorismate mutase
HUW51_10370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW51_10380	COG0077	Prephenate dehydratase
HUW51_10390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW51_10405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW51_10425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW51_10430	COG4771	TonB-dependent receptor
HUW51_10435	COG0702	epimerase
HUW51_10450	COG0535	radical SAM domain protein
HUW51_10480	COG0596	Alpha beta hydrolase
HUW51_10565	COG2366	antibiotic biosynthetic process
HUW51_10595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW51_10605	COG4974	Belongs to the 'phage' integrase family
HUW51_10610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW51_10615	COG1960	acyl-CoA dehydrogenase activity
HUW51_10625	COG0489	protein tyrosine kinase activity
HUW51_10625	COG3206	protein involved in exopolysaccharide biosynthesis
HUW51_10635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_10645	COG1809	phosphosulfolactate synthase activity
HUW51_10650	COG0586	Pfam SNARE associated Golgi protein
HUW51_10655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW51_10685	COG0556	nucleotide-excision repair
HUW51_10695	COG0431	NADPH-dependent FMN reductase
HUW51_10720	COG0583	DNA-binding transcription factor activity
HUW51_10760	COG4206	TonB-dependent receptor
HUW51_10770	COG2094	Belongs to the DNA glycosylase MPG family
HUW51_10775	COG3220	belongs to the UPF0276 family
HUW51_10785	COG0300	oxidoreductase activity
HUW51_10790	COG0024	Methionine aminopeptidase
HUW51_10820	COG3173	Aminoglycoside phosphotransferase
HUW51_10855	COG1595	DNA-templated transcription, initiation
HUW51_10865	COG4771	TonB-dependent receptor
HUW51_10870	COG0702	epimerase
HUW51_10900	COG0488	(ABC) transporter
HUW51_10960	COG4771	TonB-dependent receptor
HUW51_10975	COG0702	epimerase
HUW51_10980	COG4771	TonB-dependent receptor
HUW51_10990	COG3279	Response regulator of the LytR AlgR family
HUW51_11000	COG0280	phosphate acetyltransferase
HUW51_11000	COG0857	belongs to the CobB CobQ family
HUW51_11005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW51_11025	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_11030	COG1139	Iron-sulfur cluster binding protein
HUW51_11035	COG4941	Belongs to the sigma-70 factor family
HUW51_11065	COG2234	aminopeptidase activity
HUW51_11070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW51_11075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW51_11085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW51_11110	COG0673	inositol 2-dehydrogenase activity
HUW51_11120	COG0488	(ABC) transporter
HUW51_11125	COG1477	protein flavinylation
HUW51_11130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW51_11150	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUW51_11155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUW51_11190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW51_11205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW51_11225	COG0564	pseudouridine synthase activity
HUW51_11235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW51_11250	COG0848	biopolymer transport protein
HUW51_11265	COG3956	TIGRFAM MazG family protein
HUW51_11270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW51_11275	COG1104	cysteine desulfurase activity
HUW51_11280	COG0009	L-threonylcarbamoyladenylate synthase
HUW51_11290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUW51_11295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW51_11300	COG1160	GTP binding
HUW51_11320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUW51_11330	COG2814	Major facilitator Superfamily
HUW51_11355	COG0277	FAD linked oxidase domain protein
HUW51_11375	COG4682	membrane
HUW51_11405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW51_11425	COG1022	Amp-dependent synthetase and ligase
HUW51_11435	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW51_11435	COG1024	Enoyl-CoA hydratase
HUW51_11440	COG0183	Belongs to the thiolase family
HUW51_11450	COG1960	acyl-CoA dehydrogenase activity
HUW51_11460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW51_11470	COG4535	Mg2 and Co2 transporter CorC
HUW51_11475	COG0629	single-stranded DNA binding
HUW51_11480	COG1194	a g-specific adenine glycosylase
HUW51_11485	COG0776	regulation of translation
HUW51_11495	COG1530	ribonuclease E activity
HUW51_11515	COG1078	dGTPase activity
HUW51_11520	COG2204	response regulator
HUW51_11525	COG0802	atpase or kinase
HUW51_11550	COG4206	TonB-dependent receptor
HUW51_11555	COG3275	phosphorelay sensor kinase activity
HUW51_11560	COG3279	Response regulator of the LytR AlgR family
HUW51_11575	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_11600	COG1629	transport
HUW51_11605	COG0702	epimerase
HUW51_11625	COG2855	membrane
HUW51_11650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW51_11665	COG0450	alkyl hydroperoxide reductase
HUW51_11670	COG1629	transport
HUW51_11675	COG0702	epimerase
HUW51_11690	COG1090	epimerase
HUW51_11735	COG1418	mRNA catabolic process
HUW51_11750	COG0072	phenylalanine-tRNA ligase activity
HUW51_11750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_11760	COG2003	Belongs to the UPF0758 family
HUW51_11785	COG0667	Aldo Keto reductase
HUW51_11790	COG4585	Histidine kinase
HUW51_11820	COG1609	Transcriptional regulator
HUW51_11825	COG4771	TonB-dependent receptor
HUW51_11835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_11840	COG0673	inositol 2-dehydrogenase activity
HUW51_11860	COG0606	chelatase, subunit chli
HUW51_11870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUW51_11880	COG1132	(ABC) transporter
HUW51_11890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW51_11900	COG4771	TonB-dependent receptor
HUW51_11935	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_11940	COG2207	Transcriptional regulator
HUW51_11955	COG2205	protein histidine kinase activity
HUW51_11955	COG0745	RESPONSE REGULATOR receiver
HUW51_11955	COG3292	Two component regulator propeller
HUW51_11985	COG2197	response regulator
HUW51_11990	COG4585	Histidine kinase
HUW51_11995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_12000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_12000	COG2146	nitrite reductase [NAD(P)H] activity
HUW51_12010	COG2223	nitrite transmembrane transporter activity
HUW51_12015	COG0243	molybdopterin cofactor binding
HUW51_12025	COG0303	'Molybdopterin
HUW51_12040	COG0315	cyclic pyranopterin monophosphate synthase activity
HUW51_12040	COG0746	molybdenum cofactor guanylyltransferase activity
HUW51_12050	COG0314	molybdopterin synthase activity
HUW51_12060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUW51_12065	COG1007	ATP synthesis coupled electron transport
HUW51_12070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_12080	COG0713	ATP synthesis coupled electron transport
HUW51_12085	COG0839	Belongs to the complex I subunit 6 family
HUW51_12090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_12095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW51_12100	COG1034	ATP synthesis coupled electron transport
HUW51_12110	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUW51_12115	COG0649	NAD binding
HUW51_12120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_12125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_12130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_12135	COG0657	acetylesterase activity
HUW51_12135	COG2755	lipolytic protein G-D-S-L family
HUW51_12140	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_12170	COG1252	NADH dehydrogenase
HUW51_12175	COG0626	cystathionine gamma-synthase activity
HUW51_12185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW51_12200	COG0343	queuine tRNA-ribosyltransferase activity
HUW51_12205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW51_12215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW51_12220	COG0254	rRNA binding
HUW51_12225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_12235	COG0470	DNA polymerase III
HUW51_12240	COG0181	hydroxymethylbilane synthase activity
HUW51_12255	COG2226	methyltransferase
HUW51_12265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW51_12270	COG1331	Highly conserved protein containing a thioredoxin domain
HUW51_12280	COG0359	binds to the 23S rRNA
HUW51_12285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW51_12290	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW51_12300	COG0437	4 iron, 4 sulfur cluster binding
HUW51_12330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW51_12340	COG0109	protoheme IX farnesyltransferase activity
HUW51_12345	COG1845	cytochrome c oxidase, subunit III
HUW51_12350	COG1845	cytochrome c oxidase, subunit III
HUW51_12360	COG1999	signal sequence binding
HUW51_12365	COG2322	membrane
HUW51_12375	COG5000	phosphorelay sensor kinase activity
HUW51_12445	COG0101	tRNA pseudouridine synthase activity
HUW51_12450	COG1132	(ABC) transporter
HUW51_12485	COG4771	TonB-dependent receptor
HUW51_12490	COG0702	epimerase
HUW51_12520	COG0673	inositol 2-dehydrogenase activity
HUW51_12555	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_12565	COG2222	sugar isomerase
HUW51_12575	COG5652	VanZ like family
HUW51_12580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW51_12595	COG1506	peptidase
HUW51_12595	COG4946	Tricorn protease homolog
HUW51_12595	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_12600	COG1629	transport
HUW51_12605	COG0702	epimerase
HUW51_12620	COG1349	DNA-binding transcription factor activity
HUW51_12640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_12640	COG2207	Transcriptional regulator
HUW51_12655	COG0793	Belongs to the peptidase S41A family
HUW51_12660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUW51_12665	COG0242	peptide deformylase activity
HUW51_12675	COG2217	Heavy metal translocating P-type atpase
HUW51_12685	COG1295	ribonuclease BN
HUW51_12705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUW51_12725	COG3011	Protein conserved in bacteria
HUW51_12750	COG2323	membrane
HUW51_12780	COG4771	TonB-dependent receptor
HUW51_12795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_12800	COG0567	Dehydrogenase, E1 component
HUW51_12810	COG3850	Histidine kinase
HUW51_12810	COG3437	response regulator, receiver
HUW51_12810	COG2205	protein histidine kinase activity
HUW51_12810	COG4999	Histidine kinase
HUW51_12815	COG0784	Response regulator, receiver
HUW51_12815	COG2198	Histidine kinase
HUW51_12815	COG2205	protein histidine kinase activity
HUW51_12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW51_12820	COG2323	membrane
HUW51_12845	COG1027	Aspartate ammonia-lyase
HUW51_12860	COG0367	asparagine synthase
HUW51_12885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUW51_12900	COG0475	glutathione-regulated potassium exporter activity
HUW51_12900	COG0589	response to stress
HUW51_12925	COG0673	inositol 2-dehydrogenase activity
HUW51_12930	COG1082	Xylose isomerase domain protein TIM barrel
HUW51_12960	COG0321	lipoyl(octanoyl) transferase activity
HUW51_12960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW51_12970	COG5002	protein histidine kinase activity
HUW51_12970	COG2198	Histidine kinase
HUW51_12970	COG0784	Response regulator, receiver
HUW51_12980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW51_12985	COG0205	6-phosphofructokinase activity
HUW51_12995	COG0471	metal ion transport
HUW51_12995	COG3273	potassium ion transport
HUW51_13015	COG1595	DNA-templated transcription, initiation
HUW51_13020	COG3958	Transketolase
HUW51_13025	COG2304	oxidoreductase activity
HUW51_13030	COG3959	Transketolase, thiamine diphosphate binding domain
HUW51_13035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW51_13045	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW51_13060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW51_13065	COG0305	Participates in initiation and elongation during chromosome replication
HUW51_13070	COG4771	TonB-dependent receptor
HUW51_13075	COG0702	epimerase
HUW51_13105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_13120	COG0288	reversible hydration of carbon dioxide
HUW51_13130	COG1011	Hydrolase
HUW51_13150	COG0596	Alpha beta hydrolase
HUW51_13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW51_13200	COG0784	Response regulator, receiver
HUW51_13205	COG4191	Histidine kinase
HUW51_13215	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_13215	COG1506	peptidase
HUW51_13235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_13240	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_13255	COG3278	Belongs to the heme-copper respiratory oxidase family
HUW51_13290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW51_13295	COG0246	Mannitol dehydrogenase
HUW51_13300	COG1904	glucuronate isomerase
HUW51_13335	COG1733	regulation of RNA biosynthetic process
HUW51_13340	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_13345	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_13385	COG3119	arylsulfatase activity
HUW51_13405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_13410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_13420	COG3590	peptidase
HUW51_13430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_13470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW51_13475	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_13485	COG4771	TonB-dependent receptor
HUW51_13495	COG4771	TonB-dependent receptor
HUW51_13505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW51_13515	COG1136	(ABC) transporter
HUW51_13525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW51_13530	COG0318	PFAM AMP-dependent synthetase and ligase
HUW51_13530	COG0204	Acyl-transferase
HUW51_13550	COG1129	ABC transporter
HUW51_13555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW51_13570	COG0513	Belongs to the DEAD box helicase family
HUW51_13625	COG1054	Belongs to the UPF0176 family
HUW51_13630	COG0813	purine-nucleoside phosphorylase activity
HUW51_13645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUW51_13655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW51_13665	COG3853	Toxic anion resistance protein (TelA)
HUW51_13690	COG0667	Aldo Keto reductase
HUW51_13715	COG0667	Aldo Keto reductase
HUW51_13760	COG2814	Major facilitator Superfamily
HUW51_13820	COG4654	Cytochrome c, class I
HUW51_13825	COG1733	regulation of RNA biosynthetic process
HUW51_13860	COG2308	Evidence 4 Homologs of previously reported genes of
HUW51_13900	COG2200	EAL domain
HUW51_13955	COG2197	response regulator
HUW51_13960	COG2017	converts alpha-aldose to the beta-anomer
HUW51_13970	COG2814	Major facilitator Superfamily
HUW51_13970	COG0477	Major facilitator Superfamily
HUW51_13975	COG0457	Tetratricopeptide repeat
HUW51_13980	COG1064	alcohol dehydrogenase
HUW51_13990	COG3263	regulation of cellular component size
HUW51_13995	COG2201	protein-glutamate methylesterase activity
HUW51_14040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_14045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_14055	COG0387	Pfam Sodium calcium exchanger
HUW51_14060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_14070	COG2204	response regulator
HUW51_14075	COG5002	protein histidine kinase activity
HUW51_14080	COG2205	protein histidine kinase activity
HUW51_14090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUW51_14095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUW51_14100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUW51_14120	COG0791	NLP P60 protein
HUW51_14125	COG0367	asparagine synthase
HUW51_14135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_14140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_14145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_14155	COG2089	acid synthase
HUW51_14160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW51_14165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_14165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW51_14175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUW51_14180	COG1083	cytidylyl-transferase
HUW51_14215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW51_14255	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW51_14265	COG0563	adenylate kinase activity
HUW51_14270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW51_14275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW51_14280	COG0484	heat shock protein binding
HUW51_14285	COG4152	abc transporter atp-binding protein
HUW51_14295	COG3781	membrane
HUW51_14315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_14330	COG0438	transferase activity, transferring glycosyl groups
HUW51_14335	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_14340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW51_14365	COG0175	sulfate reduction
HUW51_14370	COG0529	Catalyzes the synthesis of activated sulfate
HUW51_14375	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUW51_14385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW51_14395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUW51_14405	COG0175	sulfate reduction
HUW51_14410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW51_14415	COG0697	spore germination
HUW51_14430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW51_14435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW51_14440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW51_14465	COG0189	ligase activity
HUW51_14465	COG4067	protein conserved in archaea
HUW51_14480	COG4585	Histidine kinase
HUW51_14485	COG2197	response regulator
HUW51_14490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW51_14525	COG0745	RESPONSE REGULATOR receiver
HUW51_14525	COG3292	Two component regulator propeller
HUW51_14525	COG2205	protein histidine kinase activity
HUW51_14530	COG2996	Protein conserved in bacteria
HUW51_14585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW51_14590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUW51_14595	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW51_14600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW51_14615	COG0714	Associated with various cellular activities
HUW51_14620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_14625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_14645	COG0516	GMP reductase activity
HUW51_14645	COG0517	IMP dehydrogenase activity
HUW51_14650	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_14680	COG1725	Transcriptional regulator
HUW51_14690	COG1131	(ABC) transporter
HUW51_14695	COG0247	lactate metabolic process
HUW51_14695	COG0277	FAD linked oxidase domain protein
HUW51_14730	COG2814	Major facilitator Superfamily
HUW51_14745	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_14750	COG2706	6-phosphogluconolactonase activity
HUW51_14755	COG0604	alcohol dehydrogenase
HUW51_14755	COG3321	synthase
HUW51_14755	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_14785	COG3781	membrane
HUW51_14795	COG1204	response to ionizing radiation
HUW51_14805	COG0667	Aldo Keto reductase
HUW51_14810	COG0667	Aldo Keto reductase
HUW51_14820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW51_14825	COG1984	allophanate hydrolase subunit 2
HUW51_14830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUW51_14835	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW51_14850	COG0193	aminoacyl-tRNA hydrolase activity
HUW51_14855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUW51_14860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW51_14870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW51_14880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW51_14885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUW51_14910	COG0628	permease
HUW51_14915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_14920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_14935	COG1278	Cold shock
HUW51_14940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW51_14960	COG1187	pseudouridine synthase activity
HUW51_15010	COG1733	regulation of RNA biosynthetic process
HUW51_15025	COG0405	Gamma-glutamyltransferase
HUW51_15040	COG1073	alpha beta
HUW51_15055	COG2271	Major facilitator Superfamily
HUW51_15105	COG2169	Transcriptional regulator
HUW51_15110	COG0673	inositol 2-dehydrogenase activity
HUW51_15155	COG1733	regulation of RNA biosynthetic process
HUW51_15170	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUW51_15175	COG2354	Protein conserved in bacteria
HUW51_15190	COG0668	transmembrane transport
HUW51_15200	COG1621	beta-fructofuranosidase activity
HUW51_15205	COG5002	protein histidine kinase activity
HUW51_15275	COG2010	Cytochrome c
HUW51_15275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_15280	COG2080	2 iron, 2 sulfur cluster binding
HUW51_15290	COG0038	chloride channel
HUW51_15315	COG1090	epimerase
HUW51_15340	COG3237	CsbD-like
HUW51_15345	COG1741	Belongs to the pirin family
HUW51_15355	COG1131	(ABC) transporter
HUW51_15375	COG2721	sulfolactate sulfo-lyase activity
HUW51_15395	COG0673	inositol 2-dehydrogenase activity
HUW51_15405	COG1858	cytochrome C peroxidase
HUW51_15420	COG1858	cytochrome C peroxidase
HUW51_15435	COG1999	signal sequence binding
HUW51_15460	COG1070	Carbohydrate kinase
HUW51_15470	COG0745	RESPONSE REGULATOR receiver
HUW51_15475	COG5002	protein histidine kinase activity
HUW51_15485	COG0288	reversible hydration of carbon dioxide
HUW51_15535	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_15580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW51_15590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_15595	COG1363	Peptidase, m42
HUW51_15600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW51_15605	COG0542	response to heat
HUW51_15620	COG0009	L-threonylcarbamoyladenylate synthase
HUW51_15625	COG2205	protein histidine kinase activity
HUW51_15625	COG0784	Response regulator, receiver
HUW51_15635	COG0824	Thioesterase
HUW51_15650	COG1464	Belongs to the NlpA lipoprotein family
HUW51_15655	COG2011	ABC-type metal ion transport system permease component
HUW51_15665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW51_15680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW51_15720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW51_15725	COG1309	transcriptional regulator
HUW51_15745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW51_15785	COG0693	protein deglycase activity
HUW51_15800	COG0673	inositol 2-dehydrogenase activity
HUW51_15820	COG0628	permease
HUW51_15830	COG0028	Belongs to the TPP enzyme family
HUW51_15845	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUW51_15870	COG1609	Transcriptional regulator
HUW51_15895	COG0681	Belongs to the peptidase S26 family
HUW51_15900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW51_15910	COG3842	ATPase activity
HUW51_15915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW51_15950	COG2885	chlorophyll binding
HUW51_15965	COG1629	transport
HUW51_15990	COG0129	dihydroxy-acid dehydratase activity
HUW51_15995	COG2610	gluconate transmembrane transporter activity
HUW51_16005	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_16010	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_16045	COG0415	Belongs to the DNA photolyase family
HUW51_16050	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_16070	COG2086	electron transfer activity
HUW51_16075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUW51_16090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW51_16095	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_16100	COG1131	(ABC) transporter
HUW51_16135	COG0717	Belongs to the dCTP deaminase family
HUW51_16140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUW51_16150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUW51_16150	COG0519	Catalyzes the synthesis of GMP from XMP
HUW51_16155	COG5002	protein histidine kinase activity
HUW51_16170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW51_16180	COG2884	Cell division ATP-binding protein ftsE
HUW51_16215	COG2089	acid synthase
HUW51_16225	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUW51_16230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_16235	COG1086	Polysaccharide biosynthesis protein
HUW51_16250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW51_16255	COG0590	tRNA wobble adenosine to inosine editing
HUW51_16290	COG1309	transcriptional regulator
HUW51_16325	COG4771	TonB-dependent receptor
HUW51_16380	COG1253	flavin adenine dinucleotide binding
HUW51_16415	COG1132	(ABC) transporter
HUW51_16445	COG2198	Histidine kinase
HUW51_16445	COG0784	Response regulator, receiver
HUW51_16445	COG0643	Histidine kinase
HUW51_16470	COG2353	YceI-like domain
HUW51_16525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW51_16545	COG1960	acyl-CoA dehydrogenase activity
HUW51_16555	COG2255	four-way junction helicase activity
HUW51_16560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUW51_16605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW51_16615	COG0572	uridine kinase
HUW51_16625	COG1702	phosphate starvation-inducible protein PhoH
HUW51_16635	COG0658	competence protein
HUW51_16635	COG2333	competence protein COMEC
HUW51_16655	COG1595	DNA-templated transcription, initiation
HUW51_16680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW51_16705	COG2001	Belongs to the MraZ family
HUW51_16710	COG0275	rRNA processing
HUW51_16720	COG0768	penicillin binding
HUW51_16725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW51_16730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW51_16735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW51_16740	COG0772	Belongs to the SEDS family
HUW51_16745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW51_16750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW51_16765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUW51_16775	COG0531	amino acid
HUW51_16785	COG1764	response to oxidative stress
HUW51_16790	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW51_16800	COG1136	(ABC) transporter
HUW51_16830	COG4251	negative regulation of phosphorylation
HUW51_16860	COG3781	membrane
HUW51_16870	COG2610	gluconate transmembrane transporter activity
HUW51_16890	COG2255	four-way junction helicase activity
HUW51_17000	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HUW51_17075	COG0616	signal peptide processing
HUW51_17210	COG1132	(ABC) transporter
HUW51_17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW51_17230	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_17240	COG1862	Preprotein translocase
HUW51_17250	COG0237	dephospho-CoA kinase activity
HUW51_17255	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_17260	COG3661	Belongs to the glycosyl hydrolase 67 family
HUW51_17270	COG2814	Major facilitator Superfamily
HUW51_17295	COG1309	transcriptional regulator
HUW51_17300	COG2133	pyrroloquinoline quinone binding
HUW51_17305	COG1940	carbohydrate kinase activity
HUW51_17310	COG2353	YceI-like domain
HUW51_17315	COG0346	lactoylglutathione lyase activity
HUW51_17340	COG3279	Response regulator of the LytR AlgR family
HUW51_17345	COG3275	phosphorelay sensor kinase activity
HUW51_17400	COG3621	Patatin-like phospholipase
HUW51_17430	COG3547	Transposase (IS116 IS110 IS902 family)
HUW51_17440	COG4771	TonB-dependent receptor
HUW51_17535	COG0247	lactate metabolic process
HUW51_17540	COG1139	Iron-sulfur cluster binding protein
HUW51_17545	COG1556	Lactate utilization protein
HUW51_17600	COG3292	Two component regulator propeller
HUW51_17600	COG2205	protein histidine kinase activity
HUW51_17600	COG0745	RESPONSE REGULATOR receiver
HUW51_17610	COG0784	Response regulator, receiver
HUW51_17610	COG4191	Histidine kinase
HUW51_17620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW51_17640	COG0431	NADPH-dependent FMN reductase
HUW51_17645	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW51_17650	COG2166	iron-sulfur cluster assembly
HUW51_17660	COG0719	Fe-S assembly protein
HUW51_17665	COG0396	ATPase activity
HUW51_17670	COG0719	Fe-S assembly protein
HUW51_17675	COG0316	Belongs to the HesB IscA family
HUW51_17685	COG0633	Ferredoxin
HUW51_17690	COG0492	ferredoxin-NADP+ reductase activity
HUW51_17710	COG1131	(ABC) transporter
HUW51_17735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_17765	COG0346	lactoylglutathione lyase activity
HUW51_17770	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUW51_17780	COG2267	carboxylic ester hydrolase activity
HUW51_17810	COG1733	regulation of RNA biosynthetic process
HUW51_17855	COG0673	inositol 2-dehydrogenase activity
HUW51_17875	COG0702	epimerase
HUW51_17880	COG4771	TonB-dependent receptor
HUW51_17890	COG4952	isomerase
HUW51_17895	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_17895	COG3347	Dehydrogenase
HUW51_17910	COG1609	Transcriptional regulator
HUW51_17915	COG4771	TonB-dependent receptor
HUW51_17930	COG1629	transport
HUW51_17930	COG4206	TonB-dependent receptor
HUW51_17950	COG1446	asparaginase
HUW51_17975	COG0318	PFAM AMP-dependent synthetase and ligase
HUW51_17980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW51_17995	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW51_18000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW51_18010	COG0406	alpha-ribazole phosphatase activity
HUW51_18030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUW51_18055	COG0488	(ABC) transporter
HUW51_18070	COG0346	lactoylglutathione lyase activity
HUW51_18080	COG0012	GTP binding
HUW51_18100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUW51_18120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW51_18130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW51_18140	COG2816	NAD+ diphosphatase activity
HUW51_18145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW51_18155	COG2363	Small membrane protein
HUW51_18160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUW51_18185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_18190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW51_18190	COG0723	plastoquinol--plastocyanin reductase activity
HUW51_18200	COG0534	Mate efflux family protein
HUW51_18205	COG0436	Aminotransferase
HUW51_18210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUW51_18215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_18225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW51_18250	COG0835	chemotaxis
HUW51_18255	COG2201	protein-glutamate methylesterase activity
HUW51_18260	COG2198	Histidine kinase
HUW51_18260	COG0643	Histidine kinase
HUW51_18265	COG1776	CheC inhibitor of MCP methylation
HUW51_18270	COG0010	Belongs to the arginase family
HUW51_18285	COG0514	ATP-dependent DNA helicase (RecQ)
HUW51_18295	COG1741	Belongs to the pirin family
HUW51_18320	COG1652	LysM domain
HUW51_18325	COG2887	Belongs to the helicase family. UvrD subfamily
HUW51_18350	COG1074	ATP-dependent DNA helicase activity
HUW51_18355	COG0513	Belongs to the DEAD box helicase family
HUW51_18405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW51_18420	COG0463	Glycosyl transferase, family 2
HUW51_18440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW51_18450	COG0671	phosphoesterase, PA-phosphatase related
HUW51_18455	COG0671	phosphoesterase, PA-phosphatase related
HUW51_18470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW51_18505	COG0463	Glycosyl transferase, family 2
HUW51_18510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW51_18520	COG0010	Belongs to the arginase family
HUW51_18525	COG0018	arginyl-trna synthetase
HUW51_18530	COG0386	Belongs to the glutathione peroxidase family
HUW51_18535	COG1575	Belongs to the MenA family. Type 1 subfamily
HUW51_18540	COG0513	Belongs to the DEAD box helicase family
HUW51_18545	COG0217	transcriptional regulatory protein
HUW51_18555	COG0488	(ABC) transporter
HUW51_18565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW51_18575	COG0754	glutathionylspermidine amidase activity
HUW51_18590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW51_18605	COG0713	ATP synthesis coupled electron transport
HUW51_18610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW51_18620	COG1007	ATP synthesis coupled electron transport
HUW51_18625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUW51_18635	COG1648	precorrin-2 dehydrogenase activity
HUW51_18635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW51_18640	COG0673	inositol 2-dehydrogenase activity
HUW51_18655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW51_18695	COG1215	transferase activity, transferring glycosyl groups
HUW51_18700	COG0084	hydrolase, TatD family'
HUW51_18705	COG0252	asparaginase activity
HUW51_18730	COG2814	Major facilitator Superfamily
HUW51_18760	COG0673	inositol 2-dehydrogenase activity
HUW51_18780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_18800	COG4251	negative regulation of phosphorylation
HUW51_18805	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUW51_18825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW51_18830	COG0673	inositol 2-dehydrogenase activity
HUW51_18860	COG3387	PFAM Glycoside hydrolase 15-related
HUW51_18875	COG0640	Transcriptional regulator
HUW51_18890	COG1187	pseudouridine synthase activity
HUW51_18895	COG0300	oxidoreductase activity
HUW51_18905	COG4771	TonB-dependent receptor
HUW51_18960	COG1222	aaa ATPase
HUW51_19135	COG5002	protein histidine kinase activity
HUW51_19140	COG3458	cephalosporin-C deacetylase activity
HUW51_19145	COG0784	Response regulator, receiver
HUW51_19145	COG5002	protein histidine kinase activity
HUW51_19145	COG2205	protein histidine kinase activity
HUW51_19150	COG1228	amidohydrolase
HUW51_19230	COG2076	Multidrug Resistance protein
HUW51_19240	COG2860	membrane
HUW51_19250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW51_19250	COG2755	lipolytic protein G-D-S-L family
HUW51_19265	COG2378	regulation of single-species biofilm formation
HUW51_19325	COG4771	TonB-dependent receptor
HUW51_19355	COG3546	catalase activity
HUW51_19365	COG0667	Aldo Keto reductase
HUW51_19400	COG0604	alcohol dehydrogenase
HUW51_19415	COG1278	Cold shock
HUW51_19460	COG0492	ferredoxin-NADP+ reductase activity
HUW51_19495	COG4771	TonB-dependent receptor
HUW51_19500	COG0702	epimerase
HUW51_19525	COG1609	Transcriptional regulator
HUW51_19540	COG0745	RESPONSE REGULATOR receiver
HUW51_19545	COG5002	protein histidine kinase activity
HUW51_19560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_19575	COG2382	esterase
HUW51_19585	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_19610	COG2755	lipolytic protein G-D-S-L family
HUW51_19610	COG0657	acetylesterase activity
HUW51_19620	COG2382	esterase
HUW51_19625	COG2382	esterase
HUW51_19630	COG2382	esterase
HUW51_19635	COG2382	esterase
HUW51_19635	COG3693	PFAM glycoside hydrolase, family 10
HUW51_19635	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_19640	COG4993	Dehydrogenase
HUW51_19650	COG3386	PFAM SMP-30 Gluconolaconase
HUW51_19655	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HUW51_19675	COG3852	Histidine kinase
HUW51_19705	COG2217	Heavy metal translocating P-type atpase
HUW51_19730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUW51_19745	COG1321	iron dependent repressor
HUW51_19750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW51_19760	COG2171	N-acyltransferase activity
HUW51_19765	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW51_19785	COG0488	(ABC) transporter
HUW51_19810	COG1104	cysteine desulfurase activity
HUW51_19815	COG0346	lactoylglutathione lyase activity
HUW51_19825	COG0617	tRNA 3'-terminal CCA addition
HUW51_19840	COG1695	Transcriptional regulator
HUW51_19865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_19870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW51_19880	COG0668	transmembrane transport
HUW51_19890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW51_19900	COG2197	response regulator
HUW51_19920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW51_19935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_19960	COG3162	membrane
HUW51_19965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW51_19970	COG0784	Response regulator, receiver
HUW51_19975	COG4251	negative regulation of phosphorylation
HUW51_19980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUW51_19985	COG2045	Belongs to the ComB family
HUW51_19990	COG1694	Mazg nucleotide pyrophosphohydrolase
HUW51_19995	COG1490	D-aminoacyl-tRNA deacylase activity
HUW51_20005	COG0598	Magnesium transport protein CorA
HUW51_20020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_20040	COG1216	Glycosyl transferase, family 2
HUW51_20080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_20085	COG1162	GTPase activity
HUW51_20090	COG1519	Transferase
HUW51_20095	COG0527	aspartate kinase activity
HUW51_20110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW51_20120	COG2226	methyltransferase
HUW51_20130	COG4221	oxidoreductase activity
HUW51_20145	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW51_20150	COG0328	RNA-DNA hybrid ribonuclease activity
HUW51_20155	COG2095	MarC family integral membrane protein
HUW51_20165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUW51_20170	COG4974	Belongs to the 'phage' integrase family
HUW51_20195	COG0167	dihydroorotate dehydrogenase activity
HUW51_20200	COG1674	ftsk spoiiie
HUW51_20215	COG0277	FAD linked oxidase domain protein
HUW51_20215	COG0247	lactate metabolic process
HUW51_20225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUW51_20230	COG0791	NLP P60 protein
HUW51_20240	COG0539	negative regulation of cytoplasmic translation
HUW51_20285	COG1063	alcohol dehydrogenase
HUW51_20290	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_20305	COG0673	inositol 2-dehydrogenase activity
HUW51_20315	COG0673	inositol 2-dehydrogenase activity
HUW51_20330	COG5002	protein histidine kinase activity
HUW51_20335	COG0165	Argininosuccinate lyase
HUW51_20350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW51_20355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW51_20360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW51_20365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUW51_20370	COG0137	argininosuccinate synthase activity
HUW51_20380	COG0287	Prephenate dehydrogenase
HUW51_20390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW51_20445	COG0463	Glycosyl transferase, family 2
HUW51_20455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW51_20475	COG2814	Major facilitator Superfamily
HUW51_20485	COG3239	Fatty acid desaturase
HUW51_20490	COG0673	inositol 2-dehydrogenase activity
HUW51_20515	COG1216	Glycosyl transferase, family 2
HUW51_20530	COG1216	Glycosyl transferase, family 2
HUW51_20530	COG0463	Glycosyl transferase, family 2
HUW51_20560	COG0438	transferase activity, transferring glycosyl groups
HUW51_20570	COG0022	dehydrogenase e1 component
HUW51_20570	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_20585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUW51_20605	COG0124	histidyl-tRNA synthetase
HUW51_20610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_20610	COG3153	acetyltransferase
HUW51_20625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW51_20630	COG0196	riboflavin kinase activity
HUW51_20635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW51_20640	COG1968	undecaprenyl-diphosphatase activity
HUW51_20650	COG2177	Part of the ABC transporter FtsEX involved in
HUW51_20660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW51_20675	COG0439	Biotin carboxylase
HUW51_20685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW51_20690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW51_20695	COG0416	fatty acid biosynthetic process
HUW51_20700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUW51_20710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUW51_20715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW51_20720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW51_20725	COG2239	Acts as a magnesium transporter
HUW51_20730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_20735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_20740	COG0537	adenosine 5'-monophosphoramidase activity
HUW51_20745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUW51_20800	COG1199	ATP-dependent helicase activity
HUW51_20800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW51_20805	COG0628	permease
HUW51_20830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW51_20835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUW51_20840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW51_20845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW51_20865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW51_20870	COG1185	polyribonucleotide nucleotidyltransferase activity
HUW51_20875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW51_20880	COG0492	ferredoxin-NADP+ reductase activity
HUW51_20885	COG0739	heme binding
HUW51_20895	COG0439	Biotin carboxylase
HUW51_20910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW51_20935	COG0811	peptide transport
HUW51_20940	COG0848	biopolymer transport protein
HUW51_20955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW51_20960	COG0135	phosphoribosylanthranilate isomerase activity
HUW51_20965	COG0482	sulfurtransferase activity
HUW51_20980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW51_20995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUW51_21000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUW51_21005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW51_21010	COG0131	Imidazoleglycerol-phosphate dehydratase
HUW51_21010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW51_21015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUW51_21020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUW51_21025	COG0107	imidazoleglycerol-phosphate synthase activity
HUW51_21030	COG0140	phosphoribosyl-ATP diphosphatase activity
HUW51_21030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUW51_21035	COG1309	transcriptional regulator
HUW51_21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_21045	COG4771	TonB-dependent receptor
HUW51_21055	COG2814	Major facilitator Superfamily
HUW51_21065	COG0673	inositol 2-dehydrogenase activity
HUW51_21095	COG2081	HI0933 family
HUW51_21105	COG3339	Conserved Protein
HUW51_21120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUW51_21150	COG1446	asparaginase
HUW51_21160	COG3685	Protein conserved in bacteria
HUW51_21185	COG1570	exodeoxyribonuclease VII activity
HUW51_21190	COG1722	exodeoxyribonuclease VII activity
HUW51_21200	COG3279	Response regulator of the LytR AlgR family
HUW51_21205	COG3275	phosphorelay sensor kinase activity
HUW51_21230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUW51_21240	COG2197	response regulator
HUW51_21245	COG4585	Histidine kinase
HUW51_21270	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_21295	COG1678	Uncharacterized ACR, COG1678
HUW51_21310	COG0424	maF-like protein
HUW51_21315	COG0667	Aldo Keto reductase
HUW51_21325	COG3483	tryptophan 2,3-dioxygenase activity
HUW51_21330	COG1760	l-serine dehydratase
HUW51_21345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW51_21375	COG1538	Outer membrane efflux protein
HUW51_21385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_21405	COG0300	oxidoreductase activity
HUW51_21410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW51_21430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW51_21435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_21470	COG0504	CTP synthase activity
HUW51_21475	COG0706	membrane insertase activity
HUW51_21480	COG0747	negative chemotaxis
HUW51_21485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_21490	COG1192	Involved in chromosome partitioning
HUW51_21495	COG1475	DNA binding
HUW51_21505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW51_21510	COG0681	Belongs to the peptidase S26 family
HUW51_21515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW51_21530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUW51_21540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW51_21540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW51_21550	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUW51_21575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW51_21590	COG0408	coproporphyrinogen oxidase activity
HUW51_21605	COG0671	phosphoesterase, PA-phosphatase related
HUW51_21630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW51_21635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW51_21640	COG1607	acyl-coa hydrolase
HUW51_21650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_21655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW51_21660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW51_21675	COG0758	DNA mediated transformation
HUW51_21685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW51_21710	COG2223	nitrite transmembrane transporter activity
HUW51_21715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUW51_21735	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_21740	COG1047	Peptidyl-prolyl cis-trans
HUW51_21745	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HUW51_21790	COG0495	leucyl-tRNA aminoacylation
HUW51_21800	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_21810	COG2315	Protein conserved in bacteria
HUW51_21815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUW51_21835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_21845	COG1119	ATPase activity
HUW51_21865	COG0577	efflux transmembrane transporter activity
HUW51_21865	COG1136	(ABC) transporter
HUW51_21885	COG1663	tetraacyldisaccharide 4'-kinase activity
HUW51_21890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW51_21905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_21910	COG3604	Transcriptional regulator
HUW51_21930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW51_21935	COG0459	protein refolding
HUW51_21945	COG3104	oligopeptide transport
HUW51_21950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW51_21965	COG1196	nuclear chromosome segregation
HUW51_21980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_21985	COG0825	malonyl-CoA metabolic process
HUW51_22015	COG1115	amino acid carrier protein
HUW51_22030	COG4134	Bacterial extracellular solute-binding protein
HUW51_22045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW51_22055	COG0659	secondary active sulfate transmembrane transporter activity
HUW51_22065	COG4651	solute:proton antiporter activity
HUW51_22065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUW51_22070	COG4585	Histidine kinase
HUW51_22125	COG4302	ethanolamine ammonia-lyase activity
HUW51_22130	COG4303	Ethanolamine ammonia lyase large subunit
HUW51_22135	COG0531	amino acid
HUW51_22155	COG0517	IMP dehydrogenase activity
HUW51_22155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW51_22160	COG0662	Cupin 2, conserved barrel domain protein
HUW51_22160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HUW51_22175	COG1981	membrane
HUW51_22190	COG1515	deoxyribonuclease V activity
HUW51_22200	COG0300	oxidoreductase activity
HUW51_22205	COG0300	oxidoreductase activity
HUW51_22215	COG0542	response to heat
HUW51_22220	COG1187	pseudouridine synthase activity
HUW51_22225	COG0443	Heat shock 70 kDa protein
HUW51_22235	COG2197	response regulator
HUW51_22250	COG4585	Histidine kinase
HUW51_22315	COG1214	PFAM Peptidase M22, glycoprotease
HUW51_22320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW51_22335	COG0829	nickel cation binding
HUW51_22340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUW51_22345	COG0830	nickel cation binding
HUW51_22350	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HUW51_22355	COG0804	urea catabolic process
HUW51_22360	COG0832	Belongs to the urease beta subunit family
HUW51_22365	COG0831	urea catabolic process
HUW51_22380	COG2176	DNA-directed DNA polymerase activity
HUW51_22405	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_22410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW51_22415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW51_22425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW51_22430	COG0698	ribose 5-phosphate isomerase
HUW51_22440	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_22450	COG2814	Major facilitator Superfamily
HUW51_22455	COG0667	Aldo Keto reductase
HUW51_22475	COG4251	negative regulation of phosphorylation
HUW51_22500	COG0339	signal peptide processing
HUW51_22535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW51_22545	COG1215	transferase activity, transferring glycosyl groups
HUW51_22585	COG3781	membrane
HUW51_22590	COG2080	2 iron, 2 sulfur cluster binding
HUW51_22595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW51_22600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_22615	COG4771	TonB-dependent receptor
HUW51_22625	COG0251	oxidation-reduction process
HUW51_22655	COG1629	transport
HUW51_22670	COG0402	S-adenosylhomocysteine deaminase activity
HUW51_22680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW51_22700	COG3254	rhamnose metabolic process
HUW51_22705	COG1725	Transcriptional regulator
HUW51_22730	COG5002	protein histidine kinase activity
HUW51_22735	COG0745	RESPONSE REGULATOR receiver
HUW51_22740	COG0673	inositol 2-dehydrogenase activity
HUW51_22750	COG1266	CAAX protease self-immunity
HUW51_22755	COG4589	Belongs to the CDS family
HUW51_22760	COG0688	phosphatidylethanolamine metabolic process
HUW51_22765	COG1956	GAF domain-containing protein
HUW51_22770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW51_22770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW51_22775	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW51_22790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW51_22800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_22805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUW51_22810	COG1228	amidohydrolase
HUW51_22820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUW51_22825	COG0656	L-ascorbic acid biosynthetic process
HUW51_22850	COG2226	methyltransferase
HUW51_22860	COG5002	protein histidine kinase activity
HUW51_22915	COG2304	oxidoreductase activity
HUW51_22925	COG0183	Belongs to the thiolase family
HUW51_22935	COG0116	Belongs to the methyltransferase superfamily
HUW51_22940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW51_22945	COG1193	negative regulation of DNA recombination
HUW51_22985	COG0673	inositol 2-dehydrogenase activity
HUW51_22990	COG0438	transferase activity, transferring glycosyl groups
HUW51_23010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW51_23020	COG0022	dehydrogenase e1 component
HUW51_23050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW51_23055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW51_23060	COG2270	Major facilitator Superfamily
HUW51_23080	COG1690	Belongs to the RtcB family
HUW51_23120	COG2160	L-arabinose isomerase activity
HUW51_23180	COG1929	Belongs to the glycerate kinase type-1 family
HUW51_23185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_23195	COG0579	oxidoreductase
HUW51_23245	COG0602	queuosine metabolic process
HUW51_23250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW51_23255	COG0481	GTPase activity
HUW51_23260	COG5002	protein histidine kinase activity
HUW51_23265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_23265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_23265	COG1703	isobutyryl-CoA mutase activity
HUW51_23275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW51_23295	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW51_23300	COG0126	phosphoglycerate kinase activity
HUW51_23335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW51_23335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW51_23350	COG0358	DNA primase activity
HUW51_23380	COG0489	protein tyrosine kinase activity
HUW51_23385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUW51_23385	COG0316	Belongs to the HesB IscA family
HUW51_23395	COG1335	isochorismatase
HUW51_23405	COG0514	ATP-dependent DNA helicase (RecQ)
HUW51_23410	COG0154	amidase activity
HUW51_23425	COG0730	response to heat
HUW51_23445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_23460	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_23470	COG2271	Major facilitator Superfamily
HUW51_23490	COG0673	inositol 2-dehydrogenase activity
HUW51_23510	COG0739	heme binding
HUW51_23545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW51_23550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW51_23555	COG2095	MarC family integral membrane protein
HUW51_23560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUW51_23565	COG2912	Transglutaminase-like superfamily
HUW51_23570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW51_23580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW51_23590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUW51_23595	COG0564	pseudouridine synthase activity
HUW51_23610	COG0228	four-way junction DNA binding
HUW51_23615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW51_23620	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW51_23625	COG0335	large ribosomal subunit rRNA binding
HUW51_23650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUW51_23655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUW51_23660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_23660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW51_23665	COG0571	ribonuclease III activity
HUW51_23670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_23675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW51_23685	COG0469	pyruvate kinase activity
HUW51_23690	COG0268	Binds directly to 16S ribosomal RNA
HUW51_23695	COG0429	hydrolase of the alpha beta-hydrolase fold
HUW51_23705	COG0366	Alpha amylase catalytic
HUW51_23715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW51_23730	COG1289	transmembrane transporter activity
HUW51_23745	COG0697	spore germination
HUW51_23765	COG3386	PFAM SMP-30 Gluconolaconase
HUW51_23775	COG0745	RESPONSE REGULATOR receiver
HUW51_23785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUW51_23790	COG0783	Belongs to the Dps family
HUW51_23815	COG0598	Magnesium transport protein CorA
HUW51_23820	COG0531	amino acid
HUW51_23835	COG2226	methyltransferase
HUW51_23850	COG3546	catalase activity
HUW51_23860	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW51_23865	COG0673	inositol 2-dehydrogenase activity
HUW51_23895	COG0667	Aldo Keto reductase
HUW51_23910	COG1643	Atp-dependent helicase
HUW51_23935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW51_23940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW51_23945	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_23950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW51_23955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW51_23960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_23970	COG0527	aspartate kinase activity
HUW51_23975	COG0019	diaminopimelate decarboxylase activity
HUW51_23995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW51_24005	COG1234	tRNA 3'-trailer cleavage
HUW51_24015	COG0180	Tryptophanyl-tRNA synthetase
HUW51_24020	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_24030	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_24030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUW51_24045	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_24050	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_24065	COG1629	transport
HUW51_24065	COG4206	TonB-dependent receptor
HUW51_24075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW51_24080	COG2226	methyltransferase
HUW51_24095	COG0587	DNA-directed DNA polymerase activity
HUW51_24105	COG1396	sequence-specific DNA binding
HUW51_24110	COG2135	peptidase activity
HUW51_24135	COG5002	protein histidine kinase activity
HUW51_24160	COG2936	dipeptidyl-peptidase activity
HUW51_24175	COG3119	arylsulfatase activity
HUW51_24180	COG3119	arylsulfatase activity
HUW51_24195	COG1629	transport
HUW51_24200	COG0702	epimerase
HUW51_24210	COG2211	Major facilitator Superfamily
HUW51_24220	COG0673	inositol 2-dehydrogenase activity
HUW51_24255	COG0745	RESPONSE REGULATOR receiver
HUW51_24255	COG3292	Two component regulator propeller
HUW51_24255	COG2205	protein histidine kinase activity
HUW51_24275	COG3291	Pkd domain containing protein
HUW51_24285	COG0561	phosphatase activity
HUW51_24290	COG4771	TonB-dependent receptor
HUW51_24300	COG3387	PFAM Glycoside hydrolase 15-related
HUW51_24305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUW51_24310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW51_24315	COG0405	Gamma-glutamyltransferase
HUW51_24320	COG4953	penicillin-binding protein 1C
HUW51_24335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUW51_24340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUW51_24375	COG3530	Putative quorum-sensing-regulated virulence factor
HUW51_24390	COG0628	permease
HUW51_24395	COG0484	heat shock protein binding
HUW51_24410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW51_24410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW51_24425	COG1309	transcriptional regulator
HUW51_24435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family