locus-tag class description AEQU_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AEQU_0002 ENOG4105VG0 50S ribosomal protein l34 AEQU_0005 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AEQU_0007 ENOG4107YBR Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AEQU_0008 ENOG4107QJE Chromosome Partitioning Protein AEQU_0009 ENOG4105FA0 parb-like partition protein AEQU_0010 ENOG4105CPF Cell wall formation (By similarity) AEQU_0012 ENOG4105DVT helicase AEQU_0016 ENOG4105Z8H single-stranded DNA-binding protein AEQU_0017 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AEQU_0018 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AEQU_0019 ENOG4105CDU Replicative dna helicase AEQU_0021 ENOG4106D4I domain protein AEQU_0023 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AEQU_0025 ENOG4105CSA Coproporphyrinogen iii oxidase AEQU_0027 ENOG4105D7V transposase AEQU_0028 ENOG4108RE9 Phosphodiesterase AEQU_0029 ENOG4105BZU Histidine kinase AEQU_0031 ENOG4105II7 pyrroline-5-carboxylate reductase AEQU_0032 ENOG4105CUB amino acid AEQU_0039 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AEQU_0041 ENOG4108TVJ Nitroreductase AEQU_0043 ENOG4107QJE Chromosome Partitioning Protein AEQU_0044 ENOG4105FA0 parb-like partition protein AEQU_0048 ENOG4105C0D helicase AEQU_0051 ENOG4105NI8 Cytosine-specific methyltransferase AEQU_0065 ENOG4108J59 Extracellular solute-binding protein, family 5 AEQU_0072 ENOG4105C0W non-ribosomal peptide synthetase AEQU_0073 ENOG4105C0W non-ribosomal peptide synthetase AEQU_0075 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AEQU_0077 ENOG4105BZ1 (ABC) transporter AEQU_0079 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AEQU_0081 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AEQU_0084 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AEQU_0088 ENOG4105C26 Dehydrogenase AEQU_0089 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AEQU_0090 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AEQU_0092 ENOG4105CMR udp-glucose 4-epimerase AEQU_0098 ENOG4105MRR Transcriptional regulator (By similarity) AEQU_0099 ENOG4105C45 hydrogenase expression formation protein (HypE) AEQU_0105 ENOG4105CFG Acts as a chaperone (By similarity) AEQU_0106 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AEQU_0107 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AEQU_0108 ENOG4105KNI merR family transcriptional Regulator AEQU_0109 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AEQU_0111 ENOG4105K8R UPF0145 protein AEQU_0113 ENOG4107QSE Dipeptidase AEQU_0114 ENOG4105DY9 regulatoR AEQU_0115 ENOG4105C89 phosphohexose isomerase AEQU_0118 ENOG4105CQS hydrogenase expression formation protein HypD AEQU_0123 ENOG4105KTH gatB Yqey AEQU_0125 ENOG4105C19 ABC transporter AEQU_0131 ENOG4105CKV Membrane AEQU_0132 ENOG4108JU5 Magnesium and cobalt efflux protein AEQU_0134 ENOG4107VEG TrkA-N domain protein AEQU_0135 ENOG4105C1A potassium transporter peripheral membrane AEQU_0139 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AEQU_0141 ENOG4105EAB amino acid AbC transporter AEQU_0142 ENOG4105E5Q amino acid AbC transporter AEQU_0143 ENOG4105CDA abc transporter atp-binding protein AEQU_0144 ENOG4105C0H protease AEQU_0145 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AEQU_0146 ENOG4105VMP Transcriptional regulator AEQU_0151 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AEQU_0152 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AEQU_0154 ENOG4105KNE Phosphatidate cytidylyltransferase AEQU_0155 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AEQU_0157 ENOG4105DZP Membrane-associated zinc metalloprotease AEQU_0158 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AEQU_0159 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AEQU_0162 ENOG4105C2N RNA methyltransferase TrmH family group 3 AEQU_0164 ENOG41067QW Transcriptional regulator AEQU_0169 ENOG4105C0H protease AEQU_0170 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_0172 ENOG4108J2R molybdopterin oxidoreductase AEQU_0173 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0175 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AEQU_0182 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_0183 ENOG4105BZU Histidine kinase AEQU_0185 ENOG4105QAX Iron-sulfur AEQU_0187 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AEQU_0193 ENOG4107QY8 reductase AEQU_0194 ENOG4105QAX Iron-sulfur AEQU_0195 ENOG4105QAX Iron-sulfur AEQU_0196 ENOG4108NEM leader-binding protein dmsD AEQU_0205 ENOG4105C3R Methionine synthase AEQU_0208 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AEQU_0209 ENOG41080U2 Amidohydrolase family AEQU_0211 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AEQU_0212 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AEQU_0213 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AEQU_0214 ENOG4108W5M transcriptional regulator AEQU_0220 ENOG4105C3J Cysteine desulfurase AEQU_0221 ENOG4105QAX Iron-sulfur AEQU_0226 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase AEQU_0227 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AEQU_0230 ENOG4105C8J )-transporter AEQU_0237 ENOG4105DB1 molybdopterin oxidoreductase AEQU_0238 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0247 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AEQU_0248 ENOG4105CSR polyphosphate kinase 2 AEQU_0249 ENOG4105KFN sortase, SrtB family AEQU_0250 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AEQU_0252 ENOG4108V3E phosphoribosylglycinamide formyltransferase AEQU_0253 ENOG4105XRQ Xanthine dehydrogenase accessory factor AEQU_0255 ENOG4105DC1 bifunctional purine biosynthesis protein purh AEQU_0259 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) AEQU_0260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AEQU_0262 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_0263 ENOG4105CP2 von willebrand factor, type a AEQU_0265 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AEQU_0266 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AEQU_0267 ENOG4105CRK lysyL-tRNA synthetase AEQU_0268 ENOG4105EYW Ion transport protein AEQU_0270 ENOG4108EE7 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AEQU_0271 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AEQU_0273 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AEQU_0278 ENOG4105C8N cysteinyl-tRNA synthetase AEQU_0281 ENOG4105CFP Peptidase U32 AEQU_0284 ENOG4108V1T peptidylprolyl cis-trans isomerase AEQU_0285 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AEQU_0286 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AEQU_0287 ENOG4105CAS nag kinase AEQU_0288 ENOG4105C8Y Acetylornithine aminotransferase AEQU_0289 ENOG4105CDH Citrulline--aspartate ligase AEQU_0291 ENOG4105BZ4 penicillin-binding protein AEQU_0293 ENOG4105CFP Peptidase U32 AEQU_0294 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AEQU_0297 ENOG4105WJF AEQU_0300 ENOG4105C9M aspartyl-trna synthetase AEQU_0302 ENOG4108RC0 Electron transport protein AEQU_0303 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AEQU_0304 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AEQU_0305 ENOG4108JPZ Monovalent cation H antiporter subunit D AEQU_0306 ENOG4107TDF Formate hydrogenlyase subunit 4 AEQU_0307 ENOG4107WQX hydrogenase 4 membrane subunit AEQU_0308 ENOG4108JPZ Monovalent cation H antiporter subunit D AEQU_0309 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AEQU_0311 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AEQU_0312 ENOG4105I6X formate hydrogenlyase maturation AEQU_0313 ENOG4108MG9 hydrogenase 3 maturation protease AEQU_0314 ENOG4105TMB Formate nitrite transporter AEQU_0315 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AEQU_0319 ENOG4105DQR SNARE associated Golgi AEQU_0321 ENOG4105C6E dna polymerase iii AEQU_0322 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AEQU_0323 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AEQU_0326 ENOG4105CSX c4-dicarboxylate anaerobic carrier AEQU_0336 ENOG4108Q5Y Membrane AEQU_0338 ENOG4105CSH Transporter AEQU_0341 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AEQU_0347 ENOG4105CIZ coA-substrate-specific enzyme activase AEQU_0348 ENOG4108NEM leader-binding protein dmsD AEQU_0350 ENOG4105QAX Iron-sulfur AEQU_0351 ENOG4105QAX Iron-sulfur AEQU_0352 ENOG4107QY8 reductase AEQU_0357 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0366 ENOG4108KQY AEQU_0368 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AEQU_0372 ENOG4105DXN mazG family AEQU_0374 ENOG4107EFR Flavocytochrome c AEQU_0375 ENOG4105CI2 imidazolone-5-propionate hydrolase AEQU_0376 ENOG4105CEU Arginine dihydrolase AEQU_0377 ENOG4105DBV ornithine carbamoyltransferase AEQU_0378 ENOG4105C5B carbamate kinase AEQU_0382 ENOG4105CSH Transporter AEQU_0385 ENOG4105CSH Transporter AEQU_0387 ENOG4105CHM Aminotransferase AEQU_0389 ENOG4108Q9V regulatoR AEQU_0393 ENOG4105WE2 aldehyde ferredoxin oxidoreductase AEQU_0394 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein AEQU_0395 ENOG4108J2R molybdopterin oxidoreductase AEQU_0396 ENOG4105QAX Iron-sulfur AEQU_0398 ENOG4108UZE carboxy-peptidase AEQU_0400 ENOG4105CB5 ATP-dependent DNA helicase recG AEQU_0402 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AEQU_0407 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AEQU_0408 ENOG4105DUM transcriptional regulator, lysR family AEQU_0409 ENOG4105C6T cysteine synthase AEQU_0410 ENOG4105BZU Histidine kinase AEQU_0416 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0417 ENOG4108WZA zeta toxin AEQU_0421 ENOG4107ZCW Low molecular weight phosphotyrosine protein phosphatase AEQU_0422 ENOG4105VXR cytoplasmic protein AEQU_0435 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein AEQU_0439 ENOG4105PNM synthesis protein AEQU_0440 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AEQU_0443 ENOG4105CHR reductase AEQU_0444 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AEQU_0445 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AEQU_0446 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AEQU_0447 ENOG4105DGA Diaminopimelate dehydrogenase AEQU_0451 ENOG4105CZV ABC transporter AEQU_0455 ENOG4105D9P serine threonine protein kinase AEQU_0459 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AEQU_0461 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AEQU_0468 ENOG4107QY8 reductase AEQU_0469 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0475 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase AEQU_0479 ENOG4105BZ1 (ABC) transporter AEQU_0480 ENOG4108JJB ABC transporter AEQU_0481 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AEQU_0484 ENOG4105EEM helicase AEQU_0487 ENOG4105DZW Dipeptidase AEQU_0489 ENOG4107TXC Transcriptional regulator AEQU_0492 ENOG4107QRT dEAD DEAH box helicase AEQU_0493 ENOG41061ZR Transcriptional regulator AEQU_0497 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AEQU_0500 ENOG4105CSX c4-dicarboxylate anaerobic carrier AEQU_0501 ENOG4105CEU Arginine dihydrolase AEQU_0502 ENOG4105DBV ornithine carbamoyltransferase AEQU_0504 ENOG4105CAG UPF0210 protein AEQU_0509 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AEQU_0513 ENOG4107B2H carbonic anhydrase AEQU_0518 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AEQU_0519 ENOG4107QY8 reductase AEQU_0520 ENOG4107SFQ iron-sulfur binding AEQU_0524 ENOG4108KGH TRANSCRIPTIONal AEQU_0532 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) AEQU_0534 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AEQU_0536 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AEQU_0537 ENOG4105F8V Hydrolase, tatD family AEQU_0541 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AEQU_0543 ENOG4108Z7F N-acetyltransferase AEQU_0544 ENOG4105C9U ATP-dependent DNA helicase RecQ AEQU_0548 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AEQU_0549 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AEQU_0550 ENOG4108BGM Quinol dehydrogenase periplasmic component AEQU_0551 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AEQU_0554 ENOG4105GXZ Ferredoxin-type protein NapH AEQU_0555 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AEQU_0557 ENOG4105DA4 cytochrome c-type biogenesis protein AEQU_0558 ENOG4108IUW ABC transporter AEQU_0566 ENOG4107EFR Flavocytochrome c AEQU_0570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AEQU_0574 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AEQU_0579 ENOG4105MZU cell filamentation protein AEQU_0580 ENOG4105DZR Type I site-specific deoxyribonuclease AEQU_0582 ENOG4108FPN Integrase AEQU_0584 ENOG4105CDW Resistance protein AEQU_0588 ENOG4107V59 shikimate AEQU_0590 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AEQU_0591 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AEQU_0592 ENOG4105D49 3-dehydroquinate synthase AEQU_0593 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AEQU_0594 ENOG4105DC7 peptidase M24 AEQU_0596 ENOG4105I7V membrAne AEQU_0597 ENOG4108NEM leader-binding protein dmsD AEQU_0598 ENOG4105QAX Iron-sulfur AEQU_0599 ENOG4105C3J Cysteine desulfurase AEQU_0601 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AEQU_0607 ENOG4107QSA Oxaloacetate decarboxylase AEQU_0608 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AEQU_0610 ENOG4105M7K Involved in the transcription termination process (By similarity) AEQU_0612 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AEQU_0614 ENOG4105BZU Histidine kinase AEQU_0615 ENOG4108YZA Nitrogen regulatory protein pii AEQU_0620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AEQU_0621 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AEQU_0622 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_0623 ENOG4107EFR Flavocytochrome c AEQU_0627 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AEQU_0628 ENOG4108ZJ4 polysaccharide deacetylase AEQU_0629 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AEQU_0633 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AEQU_0635 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AEQU_0636 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AEQU_0638 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AEQU_0639 ENOG4105BZU Histidine kinase AEQU_0642 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AEQU_0644 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase AEQU_0645 ENOG4105ESV Glycosyl transferase, family 4 AEQU_0649 ENOG4105EY8 ABC transporter AEQU_0651 ENOG4107RZX Teichoic acid biosynthesis protein AEQU_0652 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AEQU_0654 ENOG4105K64 Glycosyl transferase, family 2 AEQU_0655 ENOG4107QRS glycosyltransferase group 2 family protein AEQU_0656 ENOG4105K64 Glycosyl transferase, family 2 AEQU_0659 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AEQU_0666 ENOG4105CKK Glycosyl transferase, family 2 AEQU_0670 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AEQU_0671 ENOG4105D5G Transposase AEQU_0678 ENOG4105CIH Imidazole acetol-phosphate transaminase AEQU_0680 ENOG4107VDP teichoic acid biosynthesis AEQU_0683 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) AEQU_0684 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AEQU_0685 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) AEQU_0686 ENOG4105C1B dTDP-glucose 4-6-dehydratase AEQU_0687 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin AEQU_0690 ENOG4105KPE licD family AEQU_0692 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AEQU_0694 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AEQU_0696 ENOG4105S7A ErfK ybiS ycfS ynhG family protein AEQU_0699 ENOG4106MCE EamA-like transporter family AEQU_0701 ENOG4105VCQ rubredoxin AEQU_0704 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AEQU_0705 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AEQU_0707 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AEQU_0709 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_0710 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AEQU_0712 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_0714 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AEQU_0715 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AEQU_0717 ENOG4105EHG Permease protein AEQU_0718 ENOG4105E0A ABC, transporter AEQU_0720 ENOG4108JJB ABC transporter AEQU_0721 ENOG4108JJB ABC transporter AEQU_0722 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AEQU_0724 ENOG4105BZG amino acid carrier protein AEQU_0725 ENOG4105BZG amino acid carrier protein AEQU_0726 ENOG4105CBX hi0933 family AEQU_0727 ENOG4105DZ0 fad dependent oxidoreductase AEQU_0729 ENOG4105E5G Alpha beta hydrolase fold AEQU_0731 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AEQU_0732 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AEQU_0735 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AEQU_0737 ENOG4108UK2 deaminase AEQU_0739 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) AEQU_0740 ENOG4105ZA1 atp synthase AEQU_0742 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AEQU_0743 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AEQU_0744 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AEQU_0745 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AEQU_0751 ENOG4105C0B DNA polymerase III (alpha subunit) AEQU_0752 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AEQU_0753 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AEQU_0754 ENOG4105C8J )-transporter AEQU_0755 ENOG4105C3G gtp-binding protein AEQU_0760 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AEQU_0761 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AEQU_0762 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AEQU_0764 ENOG4105DZS Phenylacetate-CoA ligase AEQU_0766 ENOG4105EJ5 oxidoreductase gamma subunit AEQU_0769 ENOG4105DDK oxidoreductase, beta subunit AEQU_0770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AEQU_0771 ENOG4105BZU Histidine kinase AEQU_0772 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AEQU_0779 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AEQU_0781 ENOG4105CEU Arginine dihydrolase AEQU_0782 ENOG4105DBV ornithine carbamoyltransferase AEQU_0783 ENOG4105CSX c4-dicarboxylate anaerobic carrier AEQU_0784 ENOG4105C75 arginyL-tRNA synthetase AEQU_0785 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AEQU_0786 ENOG4108R6K riboflavin synthase, subunit alpha AEQU_0787 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AEQU_0791 ENOG4105CUZ uba thif-type nad fad binding protein AEQU_0793 ENOG4107SUZ Sodium/hydrogen exchanger family AEQU_0794 ENOG4105C31 Tryptophanyl-tRNA synthetase AEQU_0796 ENOG4105M6F mutator MutT protein AEQU_0797 ENOG4105C5H ABC transporter AEQU_0800 ENOG4107SUZ Sodium/hydrogen exchanger family AEQU_0802 ENOG4107EFR Flavocytochrome c AEQU_0804 ENOG4108Z4T Peptidase M50 AEQU_0805 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AEQU_0806 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AEQU_0808 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AEQU_0809 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AEQU_0811 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AEQU_0812 ENOG4105BZU Histidine kinase AEQU_0816 ENOG4105CAT Cytidine monophosphate kinase AEQU_0817 ENOG4105F6E Acyl-transferase AEQU_0818 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AEQU_0820 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AEQU_0821 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AEQU_0822 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AEQU_0824 ENOG4105BZU Histidine kinase AEQU_0826 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AEQU_0827 ENOG4105DJV ribulose-phosphate 3-epimerase AEQU_0828 ENOG4107QI6 Cysteine desulfurase AEQU_0832 ENOG4105VB9 50S ribosomal protein l28 AEQU_0833 ENOG4108ZAA Alkaline-shock protein AEQU_0834 ENOG4105DP4 dak2 domain fusion protein ylov AEQU_0836 ENOG4106H78 methyltransferase AEQU_0839 ENOG4107R4J Chloride channel AEQU_0840 ENOG41067VY 50S ribosomal protein L32 AEQU_0841 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AEQU_0842 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AEQU_0843 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AEQU_0845 ENOG4107QY8 reductase AEQU_0846 ENOG4105QAX Iron-sulfur AEQU_0850 ENOG4105C9B Cysteine desulfurase AEQU_0851 ENOG4107Y1Y Methyltransferase AEQU_0853 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AEQU_0854 ENOG4105CND Glycosyl transferase, family 2 AEQU_0859 ENOG4108IJ6 ABC transporter AEQU_0863 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AEQU_0865 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AEQU_0867 ENOG4105C1J atp-dependent rna helicase AEQU_0868 ENOG4108QBV Monogalactosyldiacylglycerol synthase AEQU_0869 ENOG410838F Glycosyl transferase family 2 AEQU_0871 ENOG4107TE5 Lipid kinase AEQU_0872 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AEQU_0873 ENOG4108ZCU PPIases accelerate the folding of proteins AEQU_0875 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AEQU_0877 ENOG4107SHJ sulfite reductase subunit b AEQU_0879 ENOG4105DPX Hydrogenase, large subunit AEQU_0880 ENOG4105DFF Rod shape-determining protein mreb AEQU_0881 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AEQU_0884 ENOG4105CNI cell division protein FtsW AEQU_0888 ENOG4107YU2 histidine triad (hIT) protein AEQU_0889 ENOG4105C6T cysteine synthase AEQU_0891 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AEQU_0892 ENOG4105E09 nadh pyrophosphatase AEQU_0894 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AEQU_0895 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AEQU_0896 ENOG41080R2 UPF0102 protein AEQU_0897 ENOG4105C0P Mg chelatase subunit ChlI AEQU_0898 ENOG4105C79 DNA protecting protein DprA AEQU_0899 ENOG4108FW6 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AEQU_0900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AEQU_0903 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AEQU_0905 ENOG4105D82 Glutamate dehydrogenase AEQU_0907 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AEQU_0919 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AEQU_0920 ENOG4105DND Transcriptional regulator AEQU_0921 ENOG4107EFR Flavocytochrome c AEQU_0922 ENOG4106V2I dimethylaminohydrolase AEQU_0923 ENOG4107EFR Flavocytochrome c AEQU_0926 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AEQU_0929 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AEQU_0931 ENOG4105CEY Amp-dependent synthetase and ligase AEQU_0934 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AEQU_0935 ENOG4105C1G acyl-Coa dehydrogenase AEQU_0937 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AEQU_0938 ENOG4105BZJ Electron transfer flavoprotein AEQU_0939 ENOG4105C10 Electron transfer flavoprotein AEQU_0940 ENOG4105DF6 Fe-S oxidoreductase AEQU_0944 ENOG4105CEY Amp-dependent synthetase and ligase AEQU_0945 ENOG4105CEY Amp-dependent synthetase and ligase AEQU_0948 ENOG4107EFR Flavocytochrome c AEQU_0951 ENOG4107QY8 reductase AEQU_0952 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_0956 ENOG4107QY8 reductase AEQU_0957 ENOG4105QAX Iron-sulfur AEQU_0959 ENOG4105C1G acyl-Coa dehydrogenase AEQU_0961 ENOG4107RSM transcriptional regulator AEQU_0962 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AEQU_0963 ENOG4105CHV Transcription elongation factor NusA AEQU_0965 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AEQU_0965 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AEQU_0966 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AEQU_0967 ENOG4105SFS phosphoesterase RecJ domain protein AEQU_0968 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AEQU_0969 ENOG4105DTN riboflavin biosynthesis protein ribF AEQU_0970 ENOG4107T7U Sulfatase AEQU_0971 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AEQU_0972 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AEQU_0973 ENOG4105CHW UPF0052 protein AEQU_0974 ENOG4105CIE May be required for sporulation (By similarity) AEQU_0976 ENOG4105BZA Phosphoglycerate kinase AEQU_0977 ENOG4105CP7 Triose-phosphate isomerase AEQU_0978 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AEQU_0982 ENOG4105EE5 Membrane protein terC AEQU_0984 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AEQU_0992 ENOG4105CBD Diacylglycerol kinase AEQU_0993 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AEQU_0995 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AEQU_0996 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AEQU_0997 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AEQU_0998 ENOG4107EFR Flavocytochrome c AEQU_0999 ENOG4108UDW Transcriptional regulator, luxr family AEQU_1000 ENOG4108IJ2 phosphate acetyltransferase AEQU_1003 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AEQU_1004 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AEQU_1006 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AEQU_1007 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AEQU_1008 ENOG4105C34 Pseudouridine synthase AEQU_1009 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AEQU_1011 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AEQU_1012 ENOG4105EGI Transcriptional regulator AEQU_1013 ENOG4107EFR Flavocytochrome c AEQU_1015 ENOG4108S01 response regulator AEQU_1016 ENOG4105CSA Coproporphyrinogen iii oxidase AEQU_1017 ENOG4107EFR Flavocytochrome c AEQU_1020 ENOG4105CWM branched-chain amino acid transport system II carrier protein AEQU_1021 ENOG4105D65 subunit l AEQU_1022 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AEQU_1023 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AEQU_1025 ENOG4108HM5 NADH-ubiquinone oxidoreductase chain 49kDa AEQU_1026 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AEQU_1028 ENOG41073R8 VanW family AEQU_1029 ENOG4105DZS Phenylacetate-CoA ligase AEQU_1031 ENOG4105DZ1 carboxypeptidase AEQU_1036 ENOG4105DZS Phenylacetate-CoA ligase AEQU_1037 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AEQU_1050 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AEQU_1051 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AEQU_1052 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AEQU_1053 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AEQU_1055 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AEQU_1056 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AEQU_1057 ENOG4105MCT stage V sporulation protein S AEQU_1059 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AEQU_1062 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AEQU_1063 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AEQU_1064 ENOG4108VPT UPF0234 protein AEQU_1066 ENOG4107QZI cell division protein FtsK AEQU_1067 ENOG4105CN5 Metallo-Beta-Lactamase AEQU_1068 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AEQU_1069 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AEQU_1070 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AEQU_1071 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AEQU_1075 ENOG4107YR5 Diacylglycerol kinase AEQU_1078 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AEQU_1079 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AEQU_1080 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AEQU_1081 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AEQU_1087 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AEQU_1088 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AEQU_1091 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AEQU_1092 ENOG4105KQC Competence protein AEQU_1093 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AEQU_1095 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AEQU_1097 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AEQU_1098 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AEQU_1099 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AEQU_1100 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AEQU_1101 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AEQU_1102 ENOG4105E0A ABC, transporter AEQU_1103 ENOG4105EHG Permease protein AEQU_1104 ENOG4105DQ5 transport system permease protein AEQU_1106 ENOG4105CD3 dihydroorotase AEQU_1107 ENOG4105CXT aspartate transcarbamylase AEQU_1108 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AEQU_1109 ENOG4108RAC Rubrerythrin AEQU_1111 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AEQU_1115 ENOG4105WGB oxidoreductase, delta subunit AEQU_1116 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AEQU_1118 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AEQU_1121 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AEQU_1122 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AEQU_1123 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AEQU_1124 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AEQU_1125 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AEQU_1127 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AEQU_1128 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AEQU_1130 ENOG4105C7K acetolactate synthase AEQU_1131 ENOG4105C01 Dihydroxy-acid dehydratase AEQU_1133 ENOG4108Z0R Transferase AEQU_1134 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AEQU_1135 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AEQU_1136 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AEQU_1138 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AEQU_1139 ENOG4105QAX Iron-sulfur AEQU_1140 ENOG4107QY8 reductase AEQU_1144 ENOG4105C3M thioredoxin reductase AEQU_1145 ENOG4108IA2 Sodium pantothenate symporter AEQU_1147 ENOG4105C22 threonyL-tRNA synthetase AEQU_1150 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AEQU_1151 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AEQU_1152 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AEQU_1153 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AEQU_1160 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AEQU_1161 ENOG4105WWX n-acetylmuramoyl-l-alanine amidase AEQU_1181 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AEQU_1196 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AEQU_1205 ENOG4108IMY Transcriptional regulator AEQU_1206 ENOG4105EYW Ion transport protein AEQU_1208 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AEQU_1209 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AEQU_1210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_1211 ENOG4105BZU Histidine kinase AEQU_1212 ENOG4105QAX Iron-sulfur AEQU_1213 ENOG4107QY8 reductase AEQU_1216 ENOG4107EFR Flavocytochrome c AEQU_1217 ENOG4105C25 Primosomal protein n' AEQU_1218 ENOG4108Z66 YbaK ebsC protein AEQU_1224 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AEQU_1227 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AEQU_1238 ENOG4105DPX Hydrogenase, large subunit AEQU_1239 ENOG4105E3S small subunit AEQU_1243 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AEQU_1244 ENOG4105CEN a g-specific adenine glycosylase AEQU_1247 ENOG4105BZ1 (ABC) transporter AEQU_1250 ENOG4108UMN azlc family AEQU_1253 ENOG4107QJE Chromosome Partitioning Protein AEQU_1254 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AEQU_1255 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AEQU_1257 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AEQU_1258 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AEQU_1259 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AEQU_1262 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AEQU_1263 ENOG4105VB6 UPF0109 protein AEQU_1267 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AEQU_1269 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AEQU_1271 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AEQU_1272 ENOG4105C8J )-transporter AEQU_1274 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_1279 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AEQU_1280 ENOG4105CN1 protease AEQU_1281 ENOG4105CRP Part of the ABC transporter FtsEX involved in AEQU_1282 ENOG4105CAK Cell division ATP-binding protein ftsE AEQU_1283 ENOG4108IUS Transketolase AEQU_1289 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AEQU_1290 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AEQU_1293 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AEQU_1294 ENOG4105C4M (Ubiquinol oxidase) subunit I AEQU_1296 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AEQU_1297 ENOG4108H0C adenylyltransferase EC 2.7.7.18 AEQU_1298 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AEQU_1299 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AEQU_1300 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AEQU_1301 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AEQU_1303 ENOG4105K46 50S ribosomal protein l27 AEQU_1304 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AEQU_1305 ENOG4105CSX c4-dicarboxylate anaerobic carrier AEQU_1306 ENOG4105CEU Arginine dihydrolase AEQU_1308 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_1309 ENOG4105C2M dna polymerase I AEQU_1310 ENOG4107NHD transcriptional regulator AEQU_1311 ENOG4105C5F glutamine synthetase AEQU_1312 ENOG41082DI 50s ribosomal protein l31 AEQU_1313 ENOG4105MAX Superoxide reductase AEQU_1314 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AEQU_1317 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AEQU_1319 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AEQU_1324 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AEQU_1327 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AEQU_1329 ENOG4108594 Permease of the drug metabolite transporter AEQU_1330 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AEQU_1335 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AEQU_1336 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AEQU_1337 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AEQU_1338 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AEQU_1339 ENOG4105CIH Imidazole acetol-phosphate transaminase AEQU_1340 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AEQU_1341 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AEQU_1342 ENOG4105C8M UPF0272 protein AEQU_1343 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase AEQU_1344 ENOG4105VUF Transcriptional regulator AEQU_1346 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AEQU_1350 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AEQU_1351 ENOG4105CN9 Peptidase m42 family protein AEQU_1356 ENOG4105EPR degv family AEQU_1359 ENOG4105EPR degv family AEQU_1360 ENOG4105DAP Nicotinate phosphoribosyltransferase AEQU_1361 ENOG4105MA4 psp1 domain protein AEQU_1362 ENOG4107QRG dna polymerase iii AEQU_1363 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AEQU_1364 ENOG4105C6K Malic enzyme AEQU_1365 ENOG4106DSS Tartrate dehydratase subunit alpha AEQU_1366 ENOG4107GFK fumarate AEQU_1368 ENOG4105C9U ATP-dependent DNA helicase RecQ AEQU_1374 ENOG4107TXC Transcriptional regulator AEQU_1375 ENOG4105DRP amino acid AbC transporter AEQU_1376 ENOG4105EAD ABC transporter AEQU_1377 ENOG4107RP9 extracellular solute-binding protein, family 3 AEQU_1379 ENOG4105CBJ Metal-dependent enzyme AEQU_1380 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AEQU_1381 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AEQU_1384 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AEQU_1387 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AEQU_1388 ENOG4105CDY transcriptional regulatory protein AEQU_1389 ENOG41061ZR Transcriptional regulator AEQU_1391 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AEQU_1392 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AEQU_1394 ENOG4105I7V membrAne AEQU_1396 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_1397 ENOG4108J2R molybdopterin oxidoreductase AEQU_1399 ENOG4108IJ6 ABC transporter AEQU_1400 ENOG4105E0C molybdate abc transporter AEQU_1407 ENOG4107EFR Flavocytochrome c AEQU_1408 ENOG4105DWF phosphomethylpyrimidine kinase AEQU_1409 ENOG4105D3W isochorismatase AEQU_1410 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AEQU_1411 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AEQU_1414 ENOG41067XK integral membrane protein AEQU_1415 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AEQU_1416 ENOG4105DFA alanine racemase domain protein AEQU_1417 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AEQU_1418 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AEQU_1420 ENOG4105D4A Cell wall formation (By similarity) AEQU_1421 ENOG4105DFU Cell wall formation (By similarity) AEQU_1422 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AEQU_1423 ENOG4105CNI cell division protein FtsW AEQU_1424 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AEQU_1428 ENOG4105CJN penicillin-binding protein AEQU_1430 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AEQU_1431 ENOG4108V6E Cell division protein mraZ AEQU_1432 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AEQU_1433 ENOG4105HDK L-asparaginase AEQU_1434 ENOG4105EN6 Membrane AEQU_1435 ENOG4105DPH UPF0371 protein AEQU_1439 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AEQU_1440 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AEQU_1441 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AEQU_1442 ENOG4105CJR Integral membrane protein (MviN AEQU_1443 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AEQU_1444 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AEQU_1445 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AEQU_1446 ENOG410683Z Preprotein translocase SecE subunit AEQU_1447 ENOG4105WDJ 50S ribosomal protein L33 AEQU_1449 ENOG4105K4H Nlp p60 protein AEQU_1450 ENOG4105CNW domain protein AEQU_1451 ENOG4105CK7 Sodium proline symporter AEQU_1452 ENOG4105XT2 Transcriptional regulator AEQU_1454 ENOG4105CG9 aspartate racemase AEQU_1456 ENOG4105I7V membrAne AEQU_1459 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AEQU_1460 ENOG4105DEF Extracellular solute-binding protein, family 5 AEQU_1462 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AEQU_1463 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AEQU_1464 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AEQU_1465 ENOG410849U 50S ribosomal protein L30 AEQU_1466 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AEQU_1467 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AEQU_1468 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AEQU_1469 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AEQU_1470 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AEQU_1471 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AEQU_1472 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AEQU_1473 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AEQU_1474 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AEQU_1475 ENOG41082SA 50s ribosomal protein l29 AEQU_1476 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AEQU_1477 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AEQU_1478 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AEQU_1479 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AEQU_1480 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AEQU_1485 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AEQU_1487 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AEQU_1495 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AEQU_1496 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AEQU_1497 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AEQU_1498 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AEQU_1499 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AEQU_1500 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AEQU_1501 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AEQU_1502 ENOG4108UDW Transcriptional regulator, luxr family AEQU_1504 ENOG4107EFR Flavocytochrome c AEQU_1507 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AEQU_1508 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AEQU_1509 ENOG4105EJQ L-serine dehydratase AEQU_1511 ENOG4106TNF Periplasmic binding protein AEQU_1517 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AEQU_1518 ENOG4105CFH Aspartokinase AEQU_1520 ENOG4105EN6 Membrane AEQU_1522 ENOG4105CJ3 phosphate transporter AEQU_1523 ENOG4105C5X domain protein AEQU_1524 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AEQU_1525 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AEQU_1526 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AEQU_1527 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AEQU_1528 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AEQU_1529 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AEQU_1531 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AEQU_1532 ENOG4105C5H ABC transporter AEQU_1533 ENOG4105C0R drug resistance transporter emrb qaca subfamily AEQU_1534 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AEQU_1535 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AEQU_1536 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AEQU_1538 ENOG4105C59 p-type ATPase AEQU_1539 ENOG4105VPX protein, conserved in bacteria AEQU_1540 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AEQU_1543 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AEQU_1545 ENOG4105D7N magnesium and cobalt transport protein CorA AEQU_1546 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AEQU_1547 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AEQU_1548 ENOG4108RIR Molybdenum cofactor biosynthesis protein AEQU_1549 ENOG4105CVM Molybdenum cofactor synthesis domain protein AEQU_1550 ENOG4105BZ1 (ABC) transporter AEQU_1552 ENOG4107EFR Flavocytochrome c AEQU_1555 ENOG4105CCI Myosin-Cross-Reactive Antigen AEQU_1557 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AEQU_1560 ENOG4108ZT0 50S ribosomal protein l17 AEQU_1561 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AEQU_1562 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AEQU_1563 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AEQU_1564 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AEQU_1565 ENOG41067V7 50S ribosomal protein L36 AEQU_1566 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AEQU_1567 ENOG4105D9M gamma-glutamylcysteine synthetase AEQU_1569 ENOG41086KC Transcriptional regulator AEQU_1572 ENOG4105CZM Major Facilitator AEQU_1575 ENOG4105D22 carbon starvation protein AEQU_1579 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AEQU_1580 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AEQU_1581 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AEQU_1582 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_1583 ENOG4105BZU Histidine kinase AEQU_1584 ENOG4105C4K Nad synthetase AEQU_1586 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AEQU_1587 ENOG4108CSZ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AEQU_1589 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AEQU_1590 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AEQU_1593 ENOG4108ZQX ybak prolyl-trna synthetase AEQU_1597 ENOG4107SFQ iron-sulfur binding AEQU_1600 ENOG4105EPW hflc protein AEQU_1603 ENOG4105EEX Two component transcriptional regulator (Winged helix family AEQU_1604 ENOG4105C08 Histidine kinase AEQU_1605 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AEQU_1607 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AEQU_1610 ENOG4105K8N protein family UPF0079, ATPase AEQU_1611 ENOG4105TMB Formate nitrite transporter AEQU_1612 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AEQU_1613 ENOG410908R Methenyltetrahydrofolate cyclohydrolase AEQU_1614 ENOG4105CKU formyltetrahydrofolate synthetase AEQU_1615 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AEQU_1616 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_1617 ENOG4105VKD bioY protein AEQU_1619 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_1620 ENOG4107QY8 reductase AEQU_1623 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AEQU_1627 ENOG4105EEI dihydropteroate synthase AEQU_1628 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AEQU_1629 ENOG4108UGV hypoxanthine phosphoribosyltransferase AEQU_1630 ENOG4108Z03 MAF-like protein AEQU_1631 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AEQU_1632 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AEQU_1633 ENOG41082T9 Membrane AEQU_1634 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AEQU_1635 ENOG41090A1 ferritin AEQU_1636 ENOG4105WPN DNA integration recombination invertion protein AEQU_1637 ENOG4108UT2 hemolysin iii AEQU_1638 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AEQU_1640 ENOG4105CV8 reductase AEQU_1641 ENOG4105SZ6 Thioredoxin AEQU_1642 ENOG4105NBF ammecr1 domain protein AEQU_1643 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase AEQU_1644 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AEQU_1645 ENOG4105CNT hydrolase family 2 AEQU_1649 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AEQU_1649 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AEQU_1655 ENOG4105QAX Iron-sulfur AEQU_1656 ENOG4105C3J Cysteine desulfurase AEQU_1658 ENOG4105CV8 reductase AEQU_1660 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AEQU_1661 ENOG4108Z86 Glutamine amidotransferase AEQU_1665 ENOG4107EFR Flavocytochrome c AEQU_1667 ENOG4105E4P ATPase (AAA AEQU_1669 ENOG4105DB7 PHP domain protein AEQU_1670 ENOG4105HRV phosphonate c-p lyase system protein phnl AEQU_1671 ENOG4105FD8 phosphonate metabolism protein PhnM AEQU_1672 ENOG4105ENV phosphonate C-P lyase system protein PhnK AEQU_1677 ENOG4105S7S phosphonate abc transporter AEQU_1679 ENOG4105D5T phosphonate abc transporter AEQU_1682 ENOG4105BZG amino acid carrier protein AEQU_1683 ENOG4105C0D helicase AEQU_1688 ENOG4105BZ1 (ABC) transporter AEQU_1689 ENOG4105EEM helicase AEQU_1692 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AEQU_1693 ENOG4105KME endoribonuclease L-psp AEQU_1702 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AEQU_1706 ENOG41082CG Protein CrcB homolog AEQU_1711 ENOG4108KSB HipA-like N-terminal domain AEQU_1713 ENOG4105CHR reductase AEQU_1715 ENOG4107EFR Flavocytochrome c AEQU_1716 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AEQU_1719 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AEQU_1721 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 AEQU_1723 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AEQU_1727 ENOG4105C5B carbamate kinase AEQU_1730 ENOG4107YB6 acetyltransferase, (GNAT) family AEQU_1733 ENOG4105CHH sulfate transporter AEQU_1734 ENOG4107EFR Flavocytochrome c AEQU_1738 ENOG4105C1A potassium transporter peripheral membrane AEQU_1739 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AEQU_1742 ENOG4105WD1 Membrane AEQU_1743 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AEQU_1744 ENOG4105CHH sulfate transporter AEQU_1745 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AEQU_1757 ENOG4105DZR Type I site-specific deoxyribonuclease AEQU_1758 ENOG41082EK Restriction modification system DNA (Specificity AEQU_1765 ENOG41064MX Tetr family transcriptional regulator AEQU_1767 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AEQU_1772 ENOG4105KTU Transcriptional regulator, arsr family AEQU_1773 ENOG4105C59 p-type ATPase AEQU_1774 ENOG4105C59 p-type ATPase AEQU_1777 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AEQU_1778 ENOG4108VZM 50s ribosomal protein L10 AEQU_1779 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_1780 ENOG4107EFR Flavocytochrome c AEQU_1784 ENOG4105CUT histidyl-tRNA synthetase AEQU_1785 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AEQU_1786 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AEQU_1787 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AEQU_1789 ENOG4105EAH synthase AEQU_1792 ENOG4105I7V membrAne AEQU_1794 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_1795 ENOG4108J2R molybdopterin oxidoreductase AEQU_1797 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_1798 ENOG4105BZU Histidine kinase AEQU_1804 ENOG4105CE1 Ferrous iron transport protein b AEQU_1807 ENOG4105D98 threonine synthase AEQU_1823 ENOG4105CJ1 ABC, transporter AEQU_1824 ENOG4105BZU Histidine kinase AEQU_1825 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_1826 ENOG4105E7U AraC family transcriptional regulator AEQU_1827 ENOG410631K Membrane AEQU_1830 ENOG4105DUM transcriptional regulator, lysR family AEQU_1831 ENOG4107R3N Filamentation induced by cAMP protein fic AEQU_1834 ENOG4105QAX Iron-sulfur AEQU_1835 ENOG4108J2R molybdopterin oxidoreductase AEQU_1837 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_1840 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AEQU_1842 ENOG4105GXZ Ferredoxin-type protein NapH AEQU_1845 ENOG4105QAX Iron-sulfur AEQU_1846 ENOG4108J2R molybdopterin oxidoreductase AEQU_1851 ENOG4105C5H ABC transporter AEQU_1853 ENOG4105CJ1 ABC, transporter AEQU_1858 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AEQU_1859 ENOG4105BZU Histidine kinase AEQU_1860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_1861 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AEQU_1863 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AEQU_1867 ENOG4105BZU Histidine kinase AEQU_1868 ENOG4105C8T Leucyl-tRNA synthetase AEQU_1870 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AEQU_1872 ENOG4105DUM transcriptional regulator, lysR family AEQU_1873 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AEQU_1877 ENOG4108RAC Rubrerythrin AEQU_1878 ENOG4105DFM M18 family aminopeptidase AEQU_1879 ENOG4105DWY Agmatine deiminase AEQU_1880 ENOG410839U amino acid AEQU_1881 ENOG4105DBV ornithine carbamoyltransferase AEQU_1885 ENOG4105CM2 brancheD-chain amino acid aminotransferase AEQU_1890 ENOG4105XJC Two component transcriptional regulator (Winged helix family AEQU_1891 ENOG41062D9 Histidine kinase AEQU_1893 ENOG4107EFR Flavocytochrome c AEQU_1900 ENOG4105QAX Iron-sulfur AEQU_1904 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AEQU_1908 ENOG4108KB2 LysR family Transcriptional regulator AEQU_1916 ENOG4105ETX regulatoR AEQU_1922 ENOG4107R11 Transcriptional regulator AEQU_1926 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) AEQU_1927 ENOG4105DKG l-rhamnose isomerase AEQU_1928 ENOG4105DET Rhamnulokinase AEQU_1933 ENOG4108UJD 30S ribosomal protein S9 AEQU_1934 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AEQU_1941 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AEQU_1944 ENOG4105EYU Glutamine amido-transferase AEQU_1945 ENOG4105CBC glutamate synthase AEQU_1947 ENOG4107EFR Flavocytochrome c AEQU_1948 ENOG4108UDW Transcriptional regulator, luxr family AEQU_1950 ENOG4105CVG Homoserine O-transsuccinylase AEQU_1953 ENOG41061ZR Transcriptional regulator AEQU_1954 ENOG4107EFR Flavocytochrome c AEQU_1957 ENOG4105QAX Iron-sulfur AEQU_1959 ENOG4107RSM transcriptional regulator AEQU_1963 ENOG41061ZR Transcriptional regulator AEQU_1977 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AEQU_1981 ENOG4105C8J )-transporter AEQU_1984 ENOG4108RSN SNARE associated Golgi AEQU_1987 ENOG4105CPF Cell wall formation (By similarity) AEQU_1988 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AEQU_1991 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AEQU_1993 ENOG4105D9P serine threonine protein kinase AEQU_1994 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AEQU_1997 ENOG4108HRK Histidine kinase AEQU_1998 ENOG41087NI Sulfite exporter TauE/SafE AEQU_2000 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AEQU_2002 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AEQU_2003 ENOG4105D4A Cell wall formation (By similarity) AEQU_2004 ENOG4107QIK phosphoribosylformylglycinamidine synthase AEQU_2006 ENOG4105C8V SAICAR synthetase AEQU_2007 ENOG4105BZU Histidine kinase AEQU_2008 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_2010 ENOG4105D17 glycoside hydrolase, family 3 domain protein AEQU_2011 ENOG4107QIV Cytochrome c biogenesis protein AEQU_2012 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AEQU_2013 ENOG4107EFR Flavocytochrome c AEQU_2016 ENOG4105C83 adenylosuccinate lyase AEQU_2019 ENOG4108Z6B deaminase AEQU_2020 ENOG4105BZN citrate synthase AEQU_2021 ENOG4105CJW magnesium transporter AEQU_2023 ENOG4105KPV Transcriptional regulator AEQU_2024 ENOG4107S6Z Na H antiporter AEQU_2028 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AEQU_2029 ENOG4105E4F Isochorismate synthase AEQU_2030 ENOG4105VUC UPF0237 protein AEQU_2031 ENOG4105EUJ GTP cyclohydrolase i AEQU_2032 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AEQU_2034 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AEQU_2035 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AEQU_2038 ENOG4105CGK Exodeoxyribonuclease III AEQU_2040 ENOG4108KGH TRANSCRIPTIONal AEQU_2042 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AEQU_2046 ENOG4107SFQ iron-sulfur binding AEQU_2047 ENOG4105C3J Cysteine desulfurase AEQU_2048 ENOG4107RSM transcriptional regulator AEQU_2049 ENOG4107EFR Flavocytochrome c AEQU_2053 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AEQU_2054 ENOG4105K78 MarR family Transcriptional regulator AEQU_2056 ENOG4105CIH Imidazole acetol-phosphate transaminase AEQU_2057 ENOG4105D5Q Arginine ornithine antiporter AEQU_2058 ENOG4108WQH regulatoR AEQU_2060 ENOG4108URH decarboxylase AEQU_2061 ENOG4105BZU Histidine kinase AEQU_2066 ENOG4107SUZ Sodium/hydrogen exchanger family AEQU_2070 ENOG4105NTD Inherit from COG: Hydrolase AEQU_2071 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AEQU_2073 ENOG4108IMY Transcriptional regulator AEQU_2079 ENOG41086D8 Transcriptional regulator AEQU_2080 ENOG4105K5X acetyltransferase AEQU_2081 ENOG4105C0R drug resistance transporter emrb qaca subfamily AEQU_2085 ENOG4105CSV Glutaminase AEQU_2086 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AEQU_2088 ENOG4106H3A restriction AEQU_2093 ENOG410630P Transcriptional regulator AEQU_2095 ENOG4107TXC Transcriptional regulator AEQU_2097 ENOG41080E8 Transcriptional regulator, Spx MgsR family AEQU_2106 ENOG4108UIN ybak prolyl-trna synthetase associated region AEQU_2110 ENOG4105E5D amino acid AEQU_2111 ENOG4105CTZ aminopeptidase c AEQU_2115 ENOG4107EFR Flavocytochrome c AEQU_2116 ENOG4105WH1 Two component transcriptional regulator luxr family AEQU_2117 ENOG4107EFR Flavocytochrome c AEQU_2118 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AEQU_2121 ENOG4105EHG Permease protein AEQU_2122 ENOG4105E0A ABC, transporter AEQU_2125 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AEQU_2126 ENOG4105BZU Histidine kinase AEQU_2132 ENOG4105VDM plasmid maintenance system antidote protein, xre family AEQU_2136 ENOG4105D7A ATP-binding protein AEQU_2138 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AEQU_2149 ENOG4105CEY Amp-dependent synthetase and ligase AEQU_2150 ENOG4108IPT Naphthoate synthase AEQU_2151 ENOG4105CZX twitching motility protein AEQU_2160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AEQU_2161 ENOG4105DZS Phenylacetate-CoA ligase AEQU_2163 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_2164 ENOG4105BZU Histidine kinase AEQU_2165 ENOG4105QAX Iron-sulfur AEQU_2167 ENOG4107QY8 reductase AEQU_2180 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AEQU_2181 ENOG4106PMH Extracellular solute-binding protein family 3 AEQU_2182 ENOG4105EAD ABC transporter AEQU_2183 ENOG4105CDA abc transporter atp-binding protein AEQU_2184 ENOG41087YS Phage shock protein A AEQU_2191 ENOG4108ZF3 Phosphatase AEQU_2193 ENOG4105D9P serine threonine protein kinase AEQU_2195 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AEQU_2196 ENOG4105BZU Histidine kinase AEQU_2197 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AEQU_2199 ENOG4105E2Z phosphate ABC transporter (Permease AEQU_2200 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AEQU_2201 ENOG4105C8U phosphate abc transporter AEQU_2202 ENOG4107S17 Phosphate-binding protein AEQU_2203 ENOG4105I7V membrAne AEQU_2205 ENOG4105QAX Iron-sulfur AEQU_2206 ENOG4107QY8 reductase AEQU_2207 ENOG4107QY8 reductase AEQU_2208 ENOG4108KB2 LysR family Transcriptional regulator AEQU_2212 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AEQU_2219 ENOG4105ECB domain protein AEQU_2221 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AEQU_2223 ENOG4107QW8 radical SAM domain protein AEQU_2224 ENOG4107QHI -hydrogenase AEQU_2226 ENOG41090P5 ferredoxin-like protein AEQU_2227 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AEQU_2228 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AEQU_2230 ENOG4105CHR reductase AEQU_2231 ENOG4107EFR Flavocytochrome c AEQU_2238 ENOG4107R3N Filamentation induced by cAMP protein fic AEQU_2241 ENOG4107EFR Flavocytochrome c AEQU_2245 ENOG4107QW4 alcohol dehydrogenase AEQU_2248 ENOG4107BJW polysaccharide deacetylase AEQU_2249 ENOG4105D7W serine acetyltransferase AEQU_2251 ENOG4105C37 (CBS) domain AEQU_2253 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AEQU_2254 ENOG4105CI3 gtp-binding protein typa AEQU_2255 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AEQU_2260 ENOG4105D5G Transposase AEQU_2269 ENOG4107QJZ Glycosyl transferase, family 2 AEQU_2277 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AEQU_2278 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AEQU_2279 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)