locus-tag	class	description
ADCFC_00020	COG3437	response regulator, receiver
ADCFC_00080	COG0431	NADPH-dependent FMN reductase
ADCFC_00080	COG1053	succinate dehydrogenase
ADCFC_00080	COG3976	FMN-binding domain protein
ADCFC_00100	COG0745	RESPONSE REGULATOR receiver
ADCFC_00110	COG2205	protein histidine kinase activity
ADCFC_00120	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_00130	COG0243	molybdopterin cofactor binding
ADCFC_00230	COG1053	succinate dehydrogenase
ADCFC_00300	COG0765	amino acid transport
ADCFC_00310	COG4598	ABC transporter
ADCFC_00340	COG1842	Phage shock protein A
ADCFC_00420	COG0631	protein serine/threonine phosphatase activity
ADCFC_00440	COG2815	serine threonine protein kinase
ADCFC_00440	COG0515	serine threonine protein kinase
ADCFC_00470	COG5002	protein histidine kinase activity
ADCFC_00480	COG0745	RESPONSE REGULATOR receiver
ADCFC_00490	COG1283	sodium-dependent phosphate transmembrane transporter activity
ADCFC_00500	COG1053	succinate dehydrogenase
ADCFC_00500	COG3976	FMN-binding domain protein
ADCFC_00500	COG0431	NADPH-dependent FMN reductase
ADCFC_00510	COG2197	response regulator
ADCFC_00530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ADCFC_00540	COG0581	inorganic phosphate transmembrane transporter activity
ADCFC_00550	COG0573	inorganic phosphate transmembrane transporter activity
ADCFC_00600	COG1131	(ABC) transporter
ADCFC_00620	COG1328	CTP reductase activity
ADCFC_00640	COG1122	ATPase activity
ADCFC_00680	COG1511	domain protein
ADCFC_00720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ADCFC_00750	COG0436	Aminotransferase
ADCFC_00800	COG1979	alcohol dehydrogenase
ADCFC_00840	COG1045	serine acetyltransferase
ADCFC_00850	COG2814	Major facilitator Superfamily
ADCFC_00860	COG1253	flavin adenine dinucleotide binding
ADCFC_00870	COG2197	response regulator
ADCFC_00880	COG1053	succinate dehydrogenase
ADCFC_00900	COG1122	ATPase activity
ADCFC_00910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ADCFC_00920	COG1217	gtp-binding protein TYPA
ADCFC_01080	COG2801	Transposase and inactivated derivatives
ADCFC_01160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ADCFC_01170	COG0187	DNA topoisomerase II activity
ADCFC_01180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ADCFC_01210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ADCFC_01220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ADCFC_01230	COG0594	ribonuclease P activity
ADCFC_01240	COG0706	membrane insertase activity
ADCFC_01250	COG1847	R3H domain protein
ADCFC_01260	COG0357	Ribosomal RNA small subunit methyltransferase G
ADCFC_01270	COG1192	Involved in chromosome partitioning
ADCFC_01330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ADCFC_01340	COG1181	Belongs to the D-alanine--D-alanine ligase family
ADCFC_01360	COG1199	ATP-dependent helicase activity
ADCFC_01360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ADCFC_01410	COG0629	single-stranded DNA binding
ADCFC_01420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ADCFC_01430	COG0359	binds to the 23S rRNA
ADCFC_01440	COG0305	Participates in initiation and elongation during chromosome replication
ADCFC_01460	COG4717	serine-type aminopeptidase activity
ADCFC_01480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ADCFC_01540	COG0622	Phosphoesterase
ADCFC_01550	COG3706	GGDEF domain
ADCFC_01570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ADCFC_01580	COG0531	amino acid
ADCFC_01630	COG1396	sequence-specific DNA binding
ADCFC_01640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADCFC_01660	COG0778	Nitroreductase
ADCFC_01680	COG1192	Involved in chromosome partitioning
ADCFC_01690	COG1475	DNA binding
ADCFC_01740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ADCFC_01770	COG0270	DNA (cytosine-5-)-methyltransferase activity
ADCFC_01920	COG4166	transmembrane transport
ADCFC_01980	COG3328	transposase activity
ADCFC_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ADCFC_02020	COG3433	isochorismatase activity
ADCFC_02020	COG2226	methyltransferase
ADCFC_02030	COG3433	isochorismatase activity
ADCFC_02030	COG2226	methyltransferase
ADCFC_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ADCFC_02040	COG1021	2,3-dihydroxybenzoate-AMP ligase
ADCFC_02070	COG1132	(ABC) transporter
ADCFC_02090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ADCFC_02110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ADCFC_02120	COG3328	transposase activity
ADCFC_02150	COG2337	Toxic component of a toxin-antitoxin (TA) module
ADCFC_02210	COG1192	Involved in chromosome partitioning
ADCFC_02240	COG1484	DNA-dependent DNA replication
ADCFC_02250	COG4584	PFAM Integrase catalytic
ADCFC_02280	COG3328	transposase activity
ADCFC_02350	COG1053	succinate dehydrogenase
ADCFC_02390	COG5002	protein histidine kinase activity
ADCFC_02450	COG1129	ABC transporter
ADCFC_02480	COG1132	(ABC) transporter
ADCFC_02520	COG1012	belongs to the aldehyde dehydrogenase family
ADCFC_02560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ADCFC_02600	COG0864	Transcriptional regulator
ADCFC_02660	COG0443	Heat shock 70 kDa protein
ADCFC_02670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ADCFC_02680	COG0484	heat shock protein binding
ADCFC_02690	COG0789	Transcriptional regulator
ADCFC_02700	COG0542	response to heat
ADCFC_02720	COG0431	NADPH-dependent FMN reductase
ADCFC_02720	COG3976	FMN-binding domain protein
ADCFC_02720	COG1053	succinate dehydrogenase
ADCFC_02730	COG1301	dicarboxylic acid transport
ADCFC_02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADCFC_02760	COG3279	Response regulator of the LytR AlgR family
ADCFC_02770	COG0166	Belongs to the GPI family
ADCFC_02780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ADCFC_02790	COG0298	carbon dioxide binding
ADCFC_02810	COG2827	Endonuclease containing a URI domain
ADCFC_02960	COG1610	YqeY-like protein
ADCFC_02970	COG0577	efflux transmembrane transporter activity
ADCFC_02980	COG1136	(ABC) transporter
ADCFC_02990	COG2205	protein histidine kinase activity
ADCFC_03040	COG3428	Bacterial PH domain
ADCFC_03050	COG4535	Mg2 and Co2 transporter CorC
ADCFC_03070	COG0569	domain protein
ADCFC_03110	COG1115	amino acid carrier protein
ADCFC_03130	COG1763	Mo-molybdopterin cofactor biosynthetic process
ADCFC_03150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADCFC_03160	COG0765	amino acid transport
ADCFC_03170	COG1126	abc transporter atp-binding protein
ADCFC_03180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADCFC_03190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADCFC_03210	COG3655	Transcriptional regulator
ADCFC_03310	COG0528	UMP kinase activity
ADCFC_03320	COG0233	cytoplasmic translational termination
ADCFC_03340	COG4589	Belongs to the CDS family
ADCFC_03350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ADCFC_03370	COG0750	zinc metalloprotease
ADCFC_03380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ADCFC_03390	COG0442	prolyl-tRNA aminoacylation
ADCFC_03420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ADCFC_03440	COG3620	sequence-specific DNA binding
ADCFC_03500	COG0644	oxidoreductase
ADCFC_03510	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ADCFC_03520	COG2814	Major facilitator Superfamily
ADCFC_03530	COG0318	PFAM AMP-dependent synthetase and ligase
ADCFC_03630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADCFC_03640	COG3328	transposase activity
ADCFC_03660	COG2197	response regulator
ADCFC_03710	COG0542	response to heat
ADCFC_03770	COG0745	RESPONSE REGULATOR receiver
ADCFC_03780	COG0784	Response regulator, receiver
ADCFC_03780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADCFC_03780	COG2198	Histidine kinase
ADCFC_03780	COG2205	protein histidine kinase activity
ADCFC_03790	COG0243	molybdopterin cofactor binding
ADCFC_03800	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_03820	COG1136	(ABC) transporter
ADCFC_03920	COG0646	methionine synthase
ADCFC_03920	COG1410	methionine synthase
ADCFC_03950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ADCFC_03960	COG0402	S-adenosylhomocysteine deaminase activity
ADCFC_03980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADCFC_03990	COG0085	RNA polymerase activity
ADCFC_04000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ADCFC_04010	COG0583	DNA-binding transcription factor activity
ADCFC_04130	COG0140	phosphoribosyl-ATP diphosphatase activity
ADCFC_04140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ADCFC_04160	COG0733	neurotransmitter:sodium symporter activity
ADCFC_04190	COG2076	Multidrug Resistance protein
ADCFC_04230	COG2326	polyphosphate kinase activity
ADCFC_04240	COG4509	Sortase family
ADCFC_04250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ADCFC_04270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ADCFC_04300	COG0138	bifunctional purine biosynthesis protein purh
ADCFC_04350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ADCFC_04370	COG1979	alcohol dehydrogenase
ADCFC_04400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADCFC_04410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ADCFC_04420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ADCFC_04430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ADCFC_04450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ADCFC_04520	COG2357	RelA SpoT domain protein
ADCFC_04560	COG0215	cysteine-tRNA ligase activity
ADCFC_04570	COG0826	peptidase U32
ADCFC_04600	COG0545	Peptidyl-prolyl cis-trans isomerase
ADCFC_04610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ADCFC_04620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ADCFC_04630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ADCFC_04640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ADCFC_04650	COG0137	argininosuccinate synthase activity
ADCFC_04670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ADCFC_04690	COG0826	peptidase U32
ADCFC_04710	COG1053	succinate dehydrogenase
ADCFC_04730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ADCFC_04780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ADCFC_04790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ADCFC_04820	COG0586	Pfam SNARE associated Golgi protein
ADCFC_04830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ADCFC_04840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ADCFC_04850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ADCFC_04880	COG1288	antiporter activity
ADCFC_04900	COG0024	Methionine aminopeptidase
ADCFC_04920	COG0697	spore germination
ADCFC_04940	COG0477	Major facilitator Superfamily
ADCFC_04970	COG0484	heat shock protein binding
ADCFC_05030	COG1924	4 iron, 4 sulfur cluster binding
ADCFC_05040	COG3381	protein complex oligomerization
ADCFC_05060	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_05070	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_05080	COG0243	molybdopterin cofactor binding
ADCFC_05100	COG2814	Major facilitator Superfamily
ADCFC_05130	COG0326	Molecular chaperone. Has ATPase activity
ADCFC_05170	COG3956	TIGRFAM MazG family protein
ADCFC_05190	COG1053	succinate dehydrogenase
ADCFC_05190	COG3976	FMN-binding domain protein
ADCFC_05200	COG3328	transposase activity
ADCFC_05230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ADCFC_05250	COG0792	nuclease activity
ADCFC_05270	COG1192	Involved in chromosome partitioning
ADCFC_05410	COG1910	domain protein
ADCFC_05500	COG0791	NLP P60 protein
ADCFC_05570	COG1484	DNA-dependent DNA replication
ADCFC_05620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ADCFC_05710	COG0640	Transcriptional regulator
ADCFC_05770	COG3177	Filamentation induced by cAMP protein fic
ADCFC_05820	COG1733	regulation of RNA biosynthetic process
ADCFC_05830	COG1373	ATPase (AAA superfamily
ADCFC_05840	COG1397	ADP-ribosylglycohydrolase
ADCFC_05850	COG3177	Filamentation induced by cAMP protein fic
ADCFC_05980	COG3328	transposase activity
ADCFC_06100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ADCFC_06110	COG1028	Short-chain dehydrogenase reductase Sdr
ADCFC_06120	COG0659	secondary active sulfate transmembrane transporter activity
ADCFC_06130	COG0363	glucosamine-6-phosphate deaminase activity
ADCFC_06180	COG2832	Protein of unknown function (DUF454)
ADCFC_06220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ADCFC_06230	COG0569	domain protein
ADCFC_06260	COG0659	secondary active sulfate transmembrane transporter activity
ADCFC_06280	COG0431	NADPH-dependent FMN reductase
ADCFC_06280	COG3976	FMN-binding domain protein
ADCFC_06280	COG1053	succinate dehydrogenase
ADCFC_06310	COG2153	protein acetylation
ADCFC_06330	COG0549	Belongs to the carbamate kinase family
ADCFC_06370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ADCFC_06390	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ADCFC_06410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ADCFC_06440	COG0446	pyridine nucleotide-disulphide oxidoreductase
ADCFC_06480	COG1028	Short-chain dehydrogenase reductase Sdr
ADCFC_06500	COG1053	succinate dehydrogenase
ADCFC_06560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ADCFC_06610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ADCFC_06610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ADCFC_06680	COG2205	protein histidine kinase activity
ADCFC_06680	COG3437	response regulator, receiver
ADCFC_06680	COG4999	Histidine kinase
ADCFC_06680	COG3850	Histidine kinase
ADCFC_06690	COG2205	protein histidine kinase activity
ADCFC_06690	COG0784	Response regulator, receiver
ADCFC_06700	COG0251	oxidation-reduction process
ADCFC_06710	COG1234	tRNA 3'-trailer cleavage
ADCFC_06740	COG3973	AAA domain
ADCFC_06750	COG1132	(ABC) transporter
ADCFC_06770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ADCFC_06780	COG1053	succinate dehydrogenase
ADCFC_06800	COG1115	amino acid carrier protein
ADCFC_06820	COG1053	succinate dehydrogenase
ADCFC_06840	COG2949	membrane
ADCFC_06870	COG1053	succinate dehydrogenase
ADCFC_06890	COG1053	succinate dehydrogenase
ADCFC_06920	COG1489	DNA binding
ADCFC_06930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ADCFC_06940	COG1490	D-aminoacyl-tRNA deacylase activity
ADCFC_06980	COG0243	molybdopterin cofactor binding
ADCFC_06990	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_07040	COG1053	succinate dehydrogenase
ADCFC_07080	COG3250	beta-galactosidase activity
ADCFC_07100	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ADCFC_07110	COG3885	ferrous iron binding
ADCFC_07110	COG2078	PFAM AMMECR1 domain protein
ADCFC_07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ADCFC_07150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ADCFC_07160	COG1272	protein, Hemolysin III
ADCFC_07170	COG1528	Iron-storage protein
ADCFC_07180	COG0577	efflux transmembrane transporter activity
ADCFC_07180	COG1136	(ABC) transporter
ADCFC_07190	COG1950	PFAM Membrane protein of
ADCFC_07200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADCFC_07210	COG0037	tRNA processing
ADCFC_07230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ADCFC_07240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADCFC_07250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ADCFC_07280	COG1268	BioY protein
ADCFC_07290	COG0745	RESPONSE REGULATOR receiver
ADCFC_07300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ADCFC_07310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ADCFC_07320	COG3404	Formiminotransferase-cyclodeaminase
ADCFC_07330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ADCFC_07340	COG2909	trisaccharide binding
ADCFC_07350	COG3976	FMN-binding domain protein
ADCFC_07350	COG1053	succinate dehydrogenase
ADCFC_07360	COG2116	formate transmembrane transporter activity
ADCFC_07370	COG0802	atpase or kinase
ADCFC_07400	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ADCFC_07430	COG2205	protein histidine kinase activity
ADCFC_07440	COG0745	RESPONSE REGULATOR receiver
ADCFC_07480	COG0243	molybdopterin cofactor binding
ADCFC_07520	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
ADCFC_07550	COG2226	methyltransferase
ADCFC_07560	COG0402	S-adenosylhomocysteine deaminase activity
ADCFC_07580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADCFC_07590	COG0805	protein transport
ADCFC_07600	COG0375	protein maturation
ADCFC_07610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ADCFC_07610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ADCFC_07620	COG4585	Histidine kinase
ADCFC_07630	COG2197	response regulator
ADCFC_07640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ADCFC_07650	COG0459	protein refolding
ADCFC_07700	COG1966	Carbon starvation protein
ADCFC_07730	COG2814	Major facilitator Superfamily
ADCFC_07740	COG2918	glutathione biosynthetic process
ADCFC_07740	COG0189	ligase activity
ADCFC_07760	COG2957	Belongs to the agmatine deiminase family
ADCFC_07770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_07810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ADCFC_07830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ADCFC_07840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ADCFC_07850	COG0202	RNA polymerase activity
ADCFC_07860	COG0203	ribosomal protein L17
ADCFC_07880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ADCFC_07900	COG4716	Myosin-crossreactive antigen
ADCFC_07940	COG3976	FMN-binding domain protein
ADCFC_07940	COG1053	succinate dehydrogenase
ADCFC_07960	COG1132	(ABC) transporter
ADCFC_07970	COG0303	'Molybdopterin
ADCFC_07980	COG0521	Mo-molybdopterin cofactor biosynthetic process
ADCFC_07990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ADCFC_08000	COG1573	uracil-dna glycosylase
ADCFC_08010	COG0598	Magnesium transport protein CorA
ADCFC_08030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ADCFC_08060	COG1937	Protein conserved in bacteria
ADCFC_08070	COG2217	Heavy metal translocating P-type atpase
ADCFC_08090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ADCFC_08100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ADCFC_08110	COG0193	aminoacyl-tRNA hydrolase activity
ADCFC_08120	COG2814	Major facilitator Superfamily
ADCFC_08130	COG0488	(ABC) transporter
ADCFC_08140	COG1739	Uncharacterized protein family UPF0029
ADCFC_08150	COG0720	synthase
ADCFC_08160	COG0602	queuosine metabolic process
ADCFC_08170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ADCFC_08190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ADCFC_08200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ADCFC_08200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ADCFC_08210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ADCFC_08220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADCFC_08230	COG0306	phosphate transporter
ADCFC_08250	COG2860	membrane
ADCFC_08280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ADCFC_08370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADCFC_08390	COG1760	l-serine dehydratase
ADCFC_08400	COG1227	inorganic diphosphatase activity
ADCFC_08410	COG2195	Cleaves the N-terminal amino acid of tripeptides
ADCFC_08440	COG1053	succinate dehydrogenase
ADCFC_08470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ADCFC_08480	COG0049	tRNA binding
ADCFC_08490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADCFC_08500	COG0051	transcription antitermination factor activity, RNA binding
ADCFC_08510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ADCFC_08520	COG0088	Forms part of the polypeptide exit tunnel
ADCFC_08530	COG0089	rRNA binding
ADCFC_08560	COG2197	response regulator
ADCFC_08610	COG1136	(ABC) transporter
ADCFC_08650	COG0544	peptidyl-prolyl cis-trans isomerase activity
ADCFC_08680	COG1053	succinate dehydrogenase
ADCFC_08690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ADCFC_08720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ADCFC_08770	COG1053	succinate dehydrogenase
ADCFC_08770	COG3976	FMN-binding domain protein
ADCFC_08780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ADCFC_08790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ADCFC_08810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ADCFC_08820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ADCFC_08840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ADCFC_08850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ADCFC_08860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ADCFC_08870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ADCFC_08880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ADCFC_08890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ADCFC_08900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ADCFC_08910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ADCFC_08920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ADCFC_08930	COG1841	ribosomal large subunit assembly
ADCFC_08940	COG0200	Binds to the 23S rRNA
ADCFC_08960	COG0563	adenylate kinase activity
ADCFC_08980	COG0747	negative chemotaxis
ADCFC_08990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ADCFC_08990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADCFC_08990	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADCFC_08990	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADCFC_09000	COG0243	molybdopterin cofactor binding
ADCFC_09020	COG2205	protein histidine kinase activity
ADCFC_09030	COG0745	RESPONSE REGULATOR receiver
ADCFC_09050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ADCFC_09050	COG3976	FMN-binding domain protein
ADCFC_09060	COG0243	molybdopterin cofactor binding
ADCFC_09070	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_09100	COG1725	Transcriptional regulator
ADCFC_09150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADCFC_09160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADCFC_09170	COG0426	domain, Protein
ADCFC_09190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ADCFC_09200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ADCFC_09210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ADCFC_09220	COG0250	Participates in transcription elongation, termination and antitermination
ADCFC_09230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ADCFC_09240	COG0081	regulation of translation
ADCFC_09250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ADCFC_09270	COG0024	Methionine aminopeptidase
ADCFC_09280	COG0504	CTP synthase activity
ADCFC_09300	COG1053	succinate dehydrogenase
ADCFC_09350	COG2860	membrane
ADCFC_09360	COG0252	asparaginase activity
ADCFC_09370	COG4974	Belongs to the 'phage' integrase family
ADCFC_09380	COG2001	Belongs to the MraZ family
ADCFC_09390	COG0275	rRNA processing
ADCFC_09410	COG0768	penicillin binding
ADCFC_09420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ADCFC_09450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ADCFC_09460	COG0772	Belongs to the SEDS family
ADCFC_09470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ADCFC_09480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ADCFC_09490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ADCFC_09500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ADCFC_09510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ADCFC_09520	COG1496	oxidoreductase activity
ADCFC_09540	COG1799	cell septum assembly
ADCFC_09550	COG0762	integral membrane protein
ADCFC_09580	COG1053	succinate dehydrogenase
ADCFC_09620	COG1564	THIamine pyrophosphokinase
ADCFC_09630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ADCFC_09640	COG0352	thiamine-phosphate diphosphorylase activity
ADCFC_09650	COG1335	isochorismatase
ADCFC_09660	COG0351	phosphomethylpyrimidine kinase
ADCFC_09680	COG0617	tRNA 3'-terminal CCA addition
ADCFC_09730	COG4149	molybdate abc transporter
ADCFC_09760	COG0243	molybdopterin cofactor binding
ADCFC_09770	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_09790	COG3976	FMN-binding domain protein
ADCFC_09790	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ADCFC_09810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADCFC_09830	COG1053	succinate dehydrogenase
ADCFC_09840	COG2909	trisaccharide binding
ADCFC_09870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADCFC_09870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADCFC_09900	COG0217	transcriptional regulatory protein
ADCFC_09910	COG1028	Short-chain dehydrogenase reductase Sdr
ADCFC_09930	COG0632	four-way junction helicase activity
ADCFC_09940	COG2255	four-way junction helicase activity
ADCFC_09960	COG1278	Cold shock
ADCFC_09970	COG2226	methyltransferase
ADCFC_09980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ADCFC_09990	COG3872	metal-dependent enzyme
ADCFC_10000	COG1126	abc transporter atp-binding protein
ADCFC_10010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADCFC_10020	COG0765	amino acid transport
ADCFC_10030	COG0765	amino acid transport
ADCFC_10110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ADCFC_10110	COG0551	DNA topoisomerase type I activity
ADCFC_10120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ADCFC_10120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ADCFC_10140	COG0281	malic enzyme
ADCFC_10150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ADCFC_10170	COG1774	PSP1 C-terminal conserved region
ADCFC_10180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ADCFC_10190	COG1307	EDD domain protein, DegV family
ADCFC_10220	COG1307	EDD domain protein, DegV family
ADCFC_10280	COG1363	Peptidase, m42
ADCFC_10290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ADCFC_10330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ADCFC_10350	COG0789	Transcriptional regulator
ADCFC_10360	COG1691	(AIR) carboxylase
ADCFC_10370	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ADCFC_10380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ADCFC_10390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ADCFC_10400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ADCFC_10410	COG0131	Imidazoleglycerol-phosphate dehydratase
ADCFC_10420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ADCFC_10430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ADCFC_10440	COG0107	imidazoleglycerol-phosphate synthase activity
ADCFC_10490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ADCFC_10520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ADCFC_10550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADCFC_10550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADCFC_10560	COG0052	Belongs to the universal ribosomal protein uS2 family
ADCFC_10570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ADCFC_10580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ADCFC_10600	COG0316	Belongs to the HesB IscA family
ADCFC_10600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ADCFC_10630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ADCFC_10640	COG2033	superoxide reductase activity
ADCFC_10660	COG0174	glutamine synthetase
ADCFC_10670	COG0745	RESPONSE REGULATOR receiver
ADCFC_10680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ADCFC_10680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ADCFC_10690	COG2197	response regulator
ADCFC_10700	COG2235	arginine
ADCFC_10710	COG1288	antiporter activity
ADCFC_10760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ADCFC_10770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ADCFC_10780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ADCFC_10790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ADCFC_10800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ADCFC_10810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ADCFC_10820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ADCFC_10820	COG1713	HD superfamily hydrolase involved in NAD metabolism
ADCFC_10830	COG0799	negative regulation of ribosome biogenesis
ADCFC_10850	COG1271	oxidase subunit
ADCFC_10860	COG1294	oxidase, subunit
ADCFC_10890	COG0653	protein targeting
ADCFC_10900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ADCFC_10920	COG3958	Transketolase
ADCFC_10930	COG2884	Cell division ATP-binding protein ftsE
ADCFC_10940	COG2177	Part of the ABC transporter FtsEX involved in
ADCFC_10960	COG0557	exoribonuclease II activity
ADCFC_11010	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_11030	COG0733	neurotransmitter:sodium symporter activity
ADCFC_11040	COG0552	protein localization to endoplasmic reticulum
ADCFC_11060	COG0747	negative chemotaxis
ADCFC_11070	COG0601	transmembrane transport
ADCFC_11080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ADCFC_11090	COG1136	(ABC) transporter
ADCFC_11120	COG1837	Belongs to the UPF0109 family
ADCFC_11140	COG0336	Belongs to the RNA methyltransferase TrmD family
ADCFC_11150	COG0681	Belongs to the peptidase S26 family
ADCFC_11160	COG0752	glycyl-tRNA synthetase alpha subunit
ADCFC_11170	COG0751	glycine-tRNA ligase activity
ADCFC_11180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ADCFC_11200	COG0574	Belongs to the PEP-utilizing enzyme family
ADCFC_11200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ADCFC_11210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADCFC_11220	COG1192	Involved in chromosome partitioning
ADCFC_11250	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ADCFC_11280	COG1132	(ABC) transporter
ADCFC_11310	COG1194	a g-specific adenine glycosylase
ADCFC_11340	COG0077	Prephenate dehydratase
ADCFC_11350	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ADCFC_11440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ADCFC_11500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADCFC_11530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ADCFC_11570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ADCFC_11580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ADCFC_11610	COG0515	serine threonine protein kinase
ADCFC_11700	COG0243	molybdopterin cofactor binding
ADCFC_11710	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_11740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ADCFC_11750	COG0116	Belongs to the methyltransferase superfamily
ADCFC_11750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADCFC_11760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ADCFC_11840	COG0544	peptidyl-prolyl cis-trans isomerase activity
ADCFC_11850	COG0740	serine-type endopeptidase activity
ADCFC_11860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ADCFC_11870	COG0525	valine-tRNA ligase activity
ADCFC_11890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ADCFC_11910	COG4145	pantothenate transmembrane transporter activity
ADCFC_11920	COG0492	ferredoxin-NADP+ reductase activity
ADCFC_11940	COG0569	domain protein
ADCFC_11940	COG0475	glutathione-regulated potassium exporter activity
ADCFC_11950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ADCFC_11960	COG2890	protein-(glutamine-N5) methyltransferase activity
ADCFC_12000	COG0129	dihydroxy-acid dehydratase activity
ADCFC_12010	COG0028	Belongs to the TPP enzyme family
ADCFC_12020	COG0440	acetolactate synthase activity
ADCFC_12030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ADCFC_12040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADCFC_12070	COG0328	RNA-DNA hybrid ribonuclease activity
ADCFC_12100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ADCFC_12110	COG0358	DNA primase activity
ADCFC_12120	COG0242	peptide deformylase activity
ADCFC_12130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ADCFC_12140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ADCFC_12140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ADCFC_12160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ADCFC_12180	COG1144	Oxidoreductase
ADCFC_12190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADCFC_12190	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADCFC_12230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ADCFC_12240	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ADCFC_12250	COG1592	Rubrerythrin
ADCFC_12260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ADCFC_12270	COG0540	Belongs to the ATCase OTCase family
ADCFC_12280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ADCFC_12290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ADCFC_12300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADCFC_12310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADCFC_12320	COG1120	ATPase activity
ADCFC_12390	COG0505	Belongs to the CarA family
ADCFC_12400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ADCFC_12410	COG0543	2 iron, 2 sulfur cluster binding
ADCFC_12420	COG0167	dihydroorotate dehydrogenase activity
ADCFC_12430	COG0284	orotidine-5'-phosphate decarboxylase activity
ADCFC_12450	COG0194	GDP metabolic process
ADCFC_12470	COG0301	tRNA thio-modification
ADCFC_12480	COG1555	photosystem II stabilization
ADCFC_12480	COG1596	polysaccharide export
ADCFC_12490	COG2333	competence protein COMEC
ADCFC_12490	COG0658	competence protein
ADCFC_12510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADCFC_12520	COG0268	Binds directly to 16S ribosomal RNA
ADCFC_12530	COG0481	GTPase activity
ADCFC_12560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ADCFC_12570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ADCFC_12580	COG1420	regulation of RNA biosynthetic process
ADCFC_12590	COG0484	heat shock protein binding
ADCFC_12600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ADCFC_12610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADCFC_12640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ADCFC_12680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ADCFC_12690	COG1185	polyribonucleotide nucleotidyltransferase activity
ADCFC_12700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ADCFC_12710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ADCFC_12720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ADCFC_12750	COG1666	GTP binding
ADCFC_12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADCFC_12770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ADCFC_12800	COG1418	mRNA catabolic process
ADCFC_12820	COG2359	stage V sporulation protein S
ADCFC_12830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADCFC_12840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ADCFC_12860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ADCFC_12870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ADCFC_12880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ADCFC_12890	COG0756	dUTP diphosphatase activity
ADCFC_13080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADCFC_13090	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ADCFC_13140	COG1686	Belongs to the peptidase S11 family
ADCFC_13170	COG2720	vancomycin resistance protein
ADCFC_13190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADCFC_13220	COG3260	NADH ubiquinone oxidoreductase 20
ADCFC_13230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ADCFC_13240	COG2111	Na H antiporter
ADCFC_13240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ADCFC_13270	COG3976	FMN-binding domain protein
ADCFC_13270	COG0431	NADPH-dependent FMN reductase
ADCFC_13270	COG1053	succinate dehydrogenase
ADCFC_13280	COG4566	intracellular signal transduction
ADCFC_13290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ADCFC_13330	COG1053	succinate dehydrogenase
ADCFC_13340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ADCFC_13350	COG0564	pseudouridine synthase activity
ADCFC_13360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ADCFC_13370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ADCFC_13390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ADCFC_13400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ADCFC_13410	COG1215	transferase activity, transferring glycosyl groups
ADCFC_13430	COG0280	phosphate acetyltransferase
ADCFC_13460	COG1053	succinate dehydrogenase
ADCFC_13460	COG3976	FMN-binding domain protein
ADCFC_13470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ADCFC_13480	COG1722	exodeoxyribonuclease VII activity
ADCFC_13490	COG1570	exodeoxyribonuclease VII activity
ADCFC_13500	COG2738	Putative neutral zinc metallopeptidase
ADCFC_13510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ADCFC_13520	COG1597	lipid kinase activity
ADCFC_13620	COG0861	Integral membrane protein TerC family
ADCFC_13650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ADCFC_13660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ADCFC_13700	COG1481	regulation of sporulation
ADCFC_13710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ADCFC_13720	COG1660	Displays ATPase and GTPase activities
ADCFC_13730	COG0322	excinuclease ABC activity
ADCFC_13750	COG0196	riboflavin kinase activity
ADCFC_13760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ADCFC_13770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ADCFC_13780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ADCFC_13790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ADCFC_13790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ADCFC_13810	COG0195	Participates in both transcription termination and antitermination
ADCFC_13820	COG0779	Required for maturation of 30S ribosomal subunits
ADCFC_13830	COG0583	DNA-binding transcription factor activity
ADCFC_13860	COG1960	acyl-CoA dehydrogenase activity
ADCFC_13880	COG1053	succinate dehydrogenase
ADCFC_13880	COG3976	FMN-binding domain protein
ADCFC_13900	COG0318	PFAM AMP-dependent synthetase and ligase
ADCFC_13910	COG0318	PFAM AMP-dependent synthetase and ligase
ADCFC_13950	COG2181	nitrate reductase activity
ADCFC_13950	COG0247	lactate metabolic process
ADCFC_13960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ADCFC_13970	COG2086	electron transfer activity
ADCFC_13980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ADCFC_14000	COG1960	acyl-CoA dehydrogenase activity
ADCFC_14040	COG0318	PFAM AMP-dependent synthetase and ligase
ADCFC_14060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADCFC_14070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ADCFC_14080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ADCFC_14120	COG1074	ATP-dependent DNA helicase activity
ADCFC_14200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ADCFC_14220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ADCFC_14240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ADCFC_14280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ADCFC_14290	COG0758	DNA mediated transformation
ADCFC_14300	COG0606	chelatase, subunit chli
ADCFC_14310	COG0792	nuclease activity
ADCFC_14320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ADCFC_14330	COG0335	large ribosomal subunit rRNA binding
ADCFC_14360	COG1151	hydroxylamine reductase activity
ADCFC_14380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ADCFC_14390	COG0537	adenosine 5'-monophosphoramidase activity
ADCFC_14430	COG0772	Belongs to the SEDS family
ADCFC_14460	COG1792	Involved in formation and maintenance of cell shape
ADCFC_14470	COG1077	Cell shape determining protein MreB Mrl
ADCFC_14480	COG3976	FMN-binding domain protein
ADCFC_14480	COG0431	NADPH-dependent FMN reductase
ADCFC_14480	COG1053	succinate dehydrogenase
ADCFC_14550	COG0105	UTP biosynthetic process
ADCFC_14570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ADCFC_14580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADCFC_14590	COG1597	lipid kinase activity
ADCFC_14620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ADCFC_14630	COG0513	Belongs to the DEAD box helicase family
ADCFC_14650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ADCFC_14670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ADCFC_14710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ADCFC_14750	COG1215	transferase activity, transferring glycosyl groups
ADCFC_14760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ADCFC_14780	COG2226	methyltransferase
ADCFC_14820	COG0243	molybdopterin cofactor binding
ADCFC_14870	COG0243	molybdopterin cofactor binding
ADCFC_14900	COG1196	nuclear chromosome segregation
ADCFC_14910	COG0571	ribonuclease III activity
ADCFC_14920	COG0416	fatty acid biosynthetic process
ADCFC_14930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ADCFC_14940	COG0038	chloride channel
ADCFC_14970	COG0742	ribosomal rna small subunit methyltransferase
ADCFC_14980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ADCFC_14990	COG1461	Dihydroxyacetone kinase
ADCFC_15000	COG1302	Protein conserved in bacteria
ADCFC_15010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ADCFC_15050	COG1104	cysteine desulfurase activity
ADCFC_15060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ADCFC_15070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ADCFC_15100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ADCFC_15110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ADCFC_15120	COG1160	GTP binding
ADCFC_15140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ADCFC_15150	COG0204	Acyl-transferase
ADCFC_15160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ADCFC_15360	COG2205	protein histidine kinase activity
ADCFC_15360	COG0784	Response regulator, receiver
ADCFC_15390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ADCFC_15400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ADCFC_15410	COG1187	pseudouridine synthase activity
ADCFC_15420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ADCFC_15440	COG1994	Peptidase M50
ADCFC_15450	COG0025	NhaP-type Na H and K H
ADCFC_15470	COG0488	(ABC) transporter
ADCFC_15480	COG0494	nUDIX hydrolase
ADCFC_15500	COG0180	Tryptophanyl-tRNA synthetase
ADCFC_15510	COG0025	NhaP-type Na H and K H
ADCFC_15530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ADCFC_15550	COG0018	arginyl-trna synthetase
ADCFC_15560	COG1288	antiporter activity
ADCFC_15570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_15580	COG2235	arginine
ADCFC_15640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADCFC_15670	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ADCFC_15680	COG2202	Pas domain
ADCFC_15680	COG2205	protein histidine kinase activity
ADCFC_15690	COG0745	RESPONSE REGULATOR receiver
ADCFC_15700	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADCFC_15710	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADCFC_15730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADCFC_15750	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ADCFC_15770	COG0549	Belongs to the carbamate kinase family
ADCFC_15800	COG2957	Belongs to the agmatine deiminase family
ADCFC_15810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_15830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ADCFC_15840	COG0154	amidase activity
ADCFC_15850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ADCFC_15890	COG0012	GTP binding
ADCFC_15900	COG0733	neurotransmitter:sodium symporter activity
ADCFC_15920	COG4656	Part of a membrane complex involved in electron transport
ADCFC_15930	COG0101	tRNA pseudouridine synthase activity
ADCFC_15990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ADCFC_16000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ADCFC_16010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ADCFC_16020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ADCFC_16030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ADCFC_16050	COG0356	it plays a direct role in the translocation of protons across the membrane
ADCFC_16070	COG2131	deaminase
ADCFC_16100	COG0698	ribose 5-phosphate isomerase
ADCFC_16110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ADCFC_16120	COG1401	restriction endodeoxyribonuclease activity
ADCFC_16150	COG2267	carboxylic ester hydrolase activity
ADCFC_16170	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ADCFC_16180	COG2081	HI0933 family
ADCFC_16190	COG1115	amino acid carrier protein
ADCFC_16200	COG1115	amino acid carrier protein
ADCFC_16220	COG4566	intracellular signal transduction
ADCFC_16250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ADCFC_16260	COG0644	oxidoreductase
ADCFC_16280	COG2086	electron transfer activity
ADCFC_16320	COG1024	Enoyl-CoA hydratase
ADCFC_16330	COG1960	acyl-CoA dehydrogenase activity
ADCFC_16350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ADCFC_16360	COG1122	ATPase activity
ADCFC_16370	COG1122	ATPase activity
ADCFC_16400	COG1120	ATPase activity
ADCFC_16410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADCFC_16430	COG0535	radical SAM domain protein
ADCFC_16460	COG2197	response regulator
ADCFC_16480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ADCFC_16480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ADCFC_16490	COG2197	response regulator
ADCFC_16520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ADCFC_16530	COG0343	queuine tRNA-ribosyltransferase activity
ADCFC_16550	COG1773	rubredoxin
ADCFC_16550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ADCFC_16590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ADCFC_16610	COG1376	ErfK ybiS ycfS ynhG family protein
ADCFC_16620	COG4193	domain, Protein
ADCFC_16630	COG1088	dTDP-glucose 4,6-dehydratase activity
ADCFC_16640	COG0151	Belongs to the GarS family
ADCFC_16670	COG0463	Glycosyl transferase, family 2
ADCFC_16680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADCFC_16710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ADCFC_16770	COG1696	Membrane protein involved in D-alanine export
ADCFC_16780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ADCFC_16810	COG1215	transferase activity, transferring glycosyl groups
ADCFC_16810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ADCFC_16830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ADCFC_16980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ADCFC_16990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ADCFC_17030	COG3328	transposase activity
ADCFC_17140	COG3328	transposase activity
ADCFC_17160	COG1216	Glycosyl transferase, family 2
ADCFC_17190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ADCFC_17240	COG1396	sequence-specific DNA binding
ADCFC_17240	COG3800	Transcriptional regulator
ADCFC_17250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ADCFC_17260	COG1134	teichoic acid transport
ADCFC_17270	COG1682	transport, permease protein
ADCFC_17290	COG3657	addiction module killer protein
ADCFC_17310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ADCFC_17320	COG3942	CHAP domain
ADCFC_17320	COG1705	Flagellar rod assembly protein muramidase FlgJ
ADCFC_17370	COG2205	protein histidine kinase activity
ADCFC_17370	COG0784	Response regulator, receiver
ADCFC_17380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ADCFC_17390	COG0736	holo-[acyl-carrier-protein] synthase activity
ADCFC_17400	COG0072	phenylalanine-tRNA ligase activity
ADCFC_17410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ADCFC_17450	COG0497	DNA recombination
ADCFC_17470	COG0556	nucleotide-excision repair
ADCFC_17500	COG1053	succinate dehydrogenase
ADCFC_17540	COG0237	dephospho-CoA kinase activity
ADCFC_17550	COG0539	negative regulation of cytoplasmic translation
ADCFC_17590	COG0347	Belongs to the P(II) protein family
ADCFC_17600	COG0004	ammonium transporteR
ADCFC_17640	COG3301	Polysulphide reductase, NrfD
ADCFC_17660	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_17670	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_17690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ADCFC_17710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ADCFC_17730	COG0439	Biotin carboxylase
ADCFC_17740	COG0511	ligase activity, forming carbon-carbon bonds
ADCFC_17740	COG5016	pyruvate
ADCFC_17760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ADCFC_17770	COG1053	succinate dehydrogenase
ADCFC_17820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ADCFC_17840	COG0243	molybdopterin cofactor binding
ADCFC_17850	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_17860	COG3381	protein complex oligomerization
ADCFC_17890	COG0006	proline dipeptidase activity
ADCFC_17900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ADCFC_17910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ADCFC_17920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ADCFC_17930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ADCFC_17950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ADCFC_17980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ADCFC_17990	COG3853	Toxic anion resistance protein (TelA)
ADCFC_18090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADCFC_18140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ADCFC_18180	COG3976	FMN-binding domain protein
ADCFC_18180	COG1053	succinate dehydrogenase
ADCFC_18230	COG1733	regulation of RNA biosynthetic process
ADCFC_18300	COG4555	ABC transporter
ADCFC_18310	COG1138	Cytochrome C-type biogenesis protein
ADCFC_18340	COG0348	domain, Protein
ADCFC_18370	COG0243	molybdopterin cofactor binding
ADCFC_18380	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_18390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADCFC_18400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ADCFC_18450	COG0538	isocitrate dehydrogenase activity
ADCFC_18460	COG0514	ATP-dependent DNA helicase (RecQ)
ADCFC_18470	COG1247	-acetyltransferase
ADCFC_18510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ADCFC_18530	COG0084	hydrolase, TatD family'
ADCFC_18540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADCFC_18540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADCFC_18550	COG2198	Histidine kinase
ADCFC_18550	COG2205	protein histidine kinase activity
ADCFC_18550	COG0784	Response regulator, receiver
ADCFC_18560	COG1959	2 iron, 2 sulfur cluster binding
ADCFC_18580	COG0822	iron-sulfur transferase activity
ADCFC_18640	COG1316	TRANSCRIPTIONal
ADCFC_18680	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_18690	COG0243	molybdopterin cofactor binding
ADCFC_18710	COG1725	Transcriptional regulator
ADCFC_18740	COG0288	reversible hydration of carbon dioxide
ADCFC_18780	COG0542	response to heat
ADCFC_18790	COG0515	serine threonine protein kinase
ADCFC_18790	COG2815	serine threonine protein kinase
ADCFC_18810	COG2848	UPF0210 protein
ADCFC_18830	COG3254	rhamnose metabolic process
ADCFC_18840	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_18850	COG0243	molybdopterin cofactor binding
ADCFC_18890	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_18900	COG0243	molybdopterin cofactor binding
ADCFC_18910	COG0824	Thioesterase
ADCFC_18920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_18930	COG2235	arginine
ADCFC_18940	COG1288	antiporter activity
ADCFC_18960	COG1396	sequence-specific DNA binding
ADCFC_18980	COG3254	rhamnose metabolic process
ADCFC_18990	COG0824	Thioesterase
ADCFC_19010	COG1053	succinate dehydrogenase
ADCFC_19030	COG1053	succinate dehydrogenase
ADCFC_19030	COG1053	succinate dehydrogenase
ADCFC_19040	COG2909	trisaccharide binding
ADCFC_19050	COG0583	DNA-binding transcription factor activity
ADCFC_19070	COG2909	trisaccharide binding
ADCFC_19080	COG1201	RNA secondary structure unwinding
ADCFC_19110	COG1053	succinate dehydrogenase
ADCFC_19120	COG0789	Transcriptional regulator
ADCFC_19170	COG3973	AAA domain
ADCFC_19180	COG0657	acetylesterase activity
ADCFC_19200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ADCFC_19210	COG1122	ATPase activity
ADCFC_19220	COG3845	ABC transporter
ADCFC_19250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_19260	COG0531	amino acid
ADCFC_19270	COG2957	Belongs to the agmatine deiminase family
ADCFC_19280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ADCFC_19330	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_19370	COG1725	Transcriptional regulator
ADCFC_19390	COG1968	undecaprenyl-diphosphatase activity
ADCFC_19430	COG2815	serine threonine protein kinase
ADCFC_19430	COG0515	serine threonine protein kinase
ADCFC_19470	COG1131	(ABC) transporter
ADCFC_19510	COG1748	Saccharopine dehydrogenase
ADCFC_19520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ADCFC_19520	COG0825	malonyl-CoA metabolic process
ADCFC_19530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ADCFC_19560	COG3321	synthase
ADCFC_19560	COG1028	Short-chain dehydrogenase reductase Sdr
ADCFC_19560	COG0604	alcohol dehydrogenase
ADCFC_19570	COG2070	2-Nitropropane dioxygenase
ADCFC_19580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ADCFC_19590	COG2843	Capsule synthesis protein
ADCFC_19640	COG0560	Phosphoserine phosphatase
ADCFC_19680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ADCFC_19710	COG0542	response to heat
ADCFC_19730	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_19800	COG0784	Response regulator, receiver
ADCFC_19800	COG2205	protein histidine kinase activity
ADCFC_19810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ADCFC_19830	COG0482	sulfurtransferase activity
ADCFC_19880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADCFC_19900	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ADCFC_20000	COG1876	peptidase activity
ADCFC_20040	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_20050	COG2414	aldehyde ferredoxin oxidoreductase
ADCFC_20110	COG0436	Aminotransferase
ADCFC_20130	COG0477	Major facilitator Superfamily
ADCFC_20140	COG1834	amidinotransferase
ADCFC_20160	COG0477	Major facilitator Superfamily
ADCFC_20190	COG1834	amidinotransferase
ADCFC_20200	COG0549	Belongs to the carbamate kinase family
ADCFC_20210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADCFC_20220	COG2235	arginine
ADCFC_20230	COG1228	amidohydrolase
ADCFC_20250	COG3328	transposase activity
ADCFC_20270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ADCFC_20280	COG1401	restriction endodeoxyribonuclease activity
ADCFC_20290	COG4268	DNA restriction-modification system
ADCFC_20340	COG4974	Belongs to the 'phage' integrase family
ADCFC_20400	COG0640	Transcriptional regulator
ADCFC_20410	COG2217	Heavy metal translocating P-type atpase
ADCFC_20420	COG2217	Heavy metal translocating P-type atpase
ADCFC_20450	COG2197	response regulator
ADCFC_20470	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_20480	COG0243	molybdopterin cofactor binding
ADCFC_20490	COG0386	Belongs to the glutathione peroxidase family
ADCFC_20500	COG0222	ribosome binding
ADCFC_20510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ADCFC_20520	COG2197	response regulator
ADCFC_20530	COG1053	succinate dehydrogenase
ADCFC_20550	COG1487	ribonuclease activity
ADCFC_20570	COG0124	histidyl-tRNA synthetase
ADCFC_20580	COG0473	3-isopropylmalate dehydrogenase activity
ADCFC_20590	COG0066	3-isopropylmalate dehydratase activity
ADCFC_20600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ADCFC_20620	COG0142	geranyltranstransferase activity
ADCFC_20650	COG3976	FMN-binding domain protein
ADCFC_20650	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ADCFC_20670	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_20680	COG0243	molybdopterin cofactor binding
ADCFC_20690	COG0745	RESPONSE REGULATOR receiver
ADCFC_20700	COG2205	protein histidine kinase activity
ADCFC_20760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ADCFC_20760	COG1918	ferrous iron import across plasma membrane
ADCFC_20940	COG1131	(ABC) transporter
ADCFC_20980	COG0697	spore germination
ADCFC_21060	COG2197	response regulator
ADCFC_21140	COG0488	(ABC) transporter
ADCFC_21210	COG1136	(ABC) transporter
ADCFC_21220	COG5002	protein histidine kinase activity
ADCFC_21240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ADCFC_21260	COG1309	transcriptional regulator
ADCFC_21300	COG0784	Response regulator, receiver
ADCFC_21300	COG2205	protein histidine kinase activity
ADCFC_21310	COG0495	leucyl-tRNA aminoacylation
ADCFC_21330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ADCFC_21350	COG0583	DNA-binding transcription factor activity
ADCFC_21390	COG1592	Rubrerythrin
ADCFC_21400	COG1362	aminopeptidase activity
ADCFC_21410	COG0549	Belongs to the carbamate kinase family
ADCFC_21420	COG2235	arginine
ADCFC_21430	COG2235	arginine
ADCFC_21440	COG2235	arginine
ADCFC_21470	COG2957	Belongs to the agmatine deiminase family
ADCFC_21480	COG0531	amino acid
ADCFC_21510	COG2197	response regulator
ADCFC_21520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ADCFC_21540	COG0549	Belongs to the carbamate kinase family
ADCFC_21570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ADCFC_21630	COG0477	Major facilitator Superfamily
ADCFC_21680	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_21710	COG2197	response regulator
ADCFC_21770	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_21830	COG2233	PERMEase
ADCFC_21860	COG2197	response regulator
ADCFC_21900	COG0745	RESPONSE REGULATOR receiver
ADCFC_21920	COG3850	Histidine kinase
ADCFC_21920	COG5002	protein histidine kinase activity
ADCFC_22060	COG2205	protein histidine kinase activity
ADCFC_22080	COG1131	(ABC) transporter
ADCFC_22090	COG0745	RESPONSE REGULATOR receiver
ADCFC_22120	COG2814	Major facilitator Superfamily
ADCFC_22130	COG0235	Class ii aldolase
ADCFC_22140	COG1070	Carbohydrate kinase
ADCFC_22140	COG4806	L-rhamnose isomerase
ADCFC_22150	COG1070	Carbohydrate kinase
ADCFC_22200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ADCFC_22210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ADCFC_22270	COG0067	glutamate synthase
ADCFC_22280	COG0069	glutamate synthase activity
ADCFC_22300	COG1053	succinate dehydrogenase
ADCFC_22330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ADCFC_22340	COG2873	o-acetylhomoserine
ADCFC_22470	COG1396	sequence-specific DNA binding
ADCFC_22490	COG0460	homoserine dehydrogenase
ADCFC_22510	COG0019	diaminopimelate decarboxylase activity
ADCFC_22540	COG0733	neurotransmitter:sodium symporter activity
ADCFC_22580	COG0398	Pfam SNARE associated Golgi protein
ADCFC_22610	COG1181	Belongs to the D-alanine--D-alanine ligase family
ADCFC_22620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADCFC_22650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ADCFC_22670	COG0515	serine threonine protein kinase
ADCFC_22670	COG2815	serine threonine protein kinase
ADCFC_22680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ADCFC_22700	COG3275	phosphorelay sensor kinase activity
ADCFC_22710	COG0730	response to heat
ADCFC_22730	COG1162	GTPase activity
ADCFC_22750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ADCFC_22770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ADCFC_22780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ADCFC_22800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ADCFC_22810	COG5002	protein histidine kinase activity
ADCFC_22820	COG0745	RESPONSE REGULATOR receiver
ADCFC_22840	COG1472	Belongs to the glycosyl hydrolase 3 family
ADCFC_22850	COG0785	Cytochrome C biogenesis protein
ADCFC_22870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ADCFC_22880	COG1053	succinate dehydrogenase
ADCFC_22950	COG2239	Acts as a magnesium transporter
ADCFC_22970	COG1959	2 iron, 2 sulfur cluster binding
ADCFC_22980	COG1757	Na H antiporter
ADCFC_22990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADCFC_23020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ADCFC_23030	COG1169	isochorismate synthase
ADCFC_23050	COG1053	succinate dehydrogenase
ADCFC_23120	COG3830	Belongs to the UPF0237 family
ADCFC_23130	COG0302	gtp cyclohydrolase
ADCFC_23170	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_23180	COG0243	molybdopterin cofactor binding
ADCFC_23200	COG0708	Exodeoxyribonuclease III
ADCFC_23210	COG1316	TRANSCRIPTIONal
ADCFC_23220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ADCFC_23230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ADCFC_23270	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_23280	COG0243	molybdopterin cofactor binding
ADCFC_23290	COG0583	DNA-binding transcription factor activity
ADCFC_23310	COG1053	succinate dehydrogenase
ADCFC_23360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ADCFC_23370	COG3189	MarR family transcriptional regulator
ADCFC_23380	COG2233	PERMEase
ADCFC_23390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ADCFC_23410	COG2197	response regulator
ADCFC_23440	COG3447	MASE1 domain protein
ADCFC_23440	COG5002	protein histidine kinase activity
ADCFC_23440	COG5001	Diguanylate cyclase
ADCFC_23480	COG0025	NhaP-type Na H and K H
ADCFC_23490	COG0519	Catalyzes the synthesis of GMP from XMP
ADCFC_23510	COG1396	sequence-specific DNA binding
ADCFC_23540	COG0657	acetylesterase activity
ADCFC_23580	COG0456	acetyltransferase
ADCFC_23600	COG0477	Major facilitator Superfamily
ADCFC_23620	COG2066	Belongs to the glutaminase family
ADCFC_23630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ADCFC_23650	COG1715	Restriction endonuclease
ADCFC_23720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ADCFC_23730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ADCFC_23760	COG1307	EDD domain protein, DegV family
ADCFC_23770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ADCFC_23800	COG0437	4 iron, 4 sulfur cluster binding
ADCFC_23810	COG0243	molybdopterin cofactor binding
ADCFC_23840	COG1393	Belongs to the ArsC family
ADCFC_23860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ADCFC_23920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ADCFC_23960	COG0531	amino acid
ADCFC_24000	COG2223	nitrite transmembrane transporter activity
ADCFC_24070	COG0431	NADPH-dependent FMN reductase
ADCFC_24070	COG1053	succinate dehydrogenase
ADCFC_24070	COG3976	FMN-binding domain protein
ADCFC_24080	COG3976	FMN-binding domain protein
ADCFC_24080	COG0431	NADPH-dependent FMN reductase
ADCFC_24080	COG1053	succinate dehydrogenase
ADCFC_24110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADCFC_24120	COG1120	ATPase activity
ADCFC_24150	COG0745	RESPONSE REGULATOR receiver
ADCFC_24160	COG2205	protein histidine kinase activity
ADCFC_24190	COG1733	regulation of RNA biosynthetic process
ADCFC_24230	COG0433	COG0433 Predicted ATPase
ADCFC_24240	COG0390	transport system, permease component
ADCFC_24250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ADCFC_24440	COG0318	PFAM AMP-dependent synthetase and ligase