locus-tag	class	description
TKWG_00025	COG0697	spore germination
TKWG_00030	COG1309	transcriptional regulator
TKWG_00055	COG0583	DNA-binding transcription factor activity
TKWG_00095	COG1733	regulation of RNA biosynthetic process
TKWG_00130	COG0583	DNA-binding transcription factor activity
TKWG_00135	COG1335	isochorismatase
TKWG_00155	COG0625	glutathione transferase activity
TKWG_00170	COG0625	glutathione transferase activity
TKWG_00175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TKWG_00190	COG1802	Transcriptional regulator
TKWG_00205	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_00210	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_00215	COG1063	alcohol dehydrogenase
TKWG_00220	COG3962	Belongs to the TPP enzyme family
TKWG_00240	COG1522	sequence-specific DNA binding
TKWG_00255	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_00270	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_00280	COG1802	Transcriptional regulator
TKWG_00290	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_00300	COG0179	Fumarylacetoacetate (FAA) hydrolase
TKWG_00305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_00310	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_00325	COG0251	oxidation-reduction process
TKWG_00345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKWG_00350	COG0798	PFAM Bile acid sodium symporter
TKWG_00370	COG2205	protein histidine kinase activity
TKWG_00385	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TKWG_00390	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TKWG_00395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TKWG_00400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TKWG_00405	COG1140	nitrate reductase beta subunit
TKWG_00410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TKWG_00415	COG2181	nitrate reductase activity
TKWG_00430	COG1250	3-hydroxyacyl-CoA dehydrogenase
TKWG_00435	COG3257	ureidoglycine aminohydrolase activity
TKWG_00445	COG1301	dicarboxylic acid transport
TKWG_00460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TKWG_00490	COG1414	Transcriptional regulator
TKWG_00495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TKWG_00500	COG3485	protocatechuate 3,4-dioxygenase
TKWG_00515	COG0583	DNA-binding transcription factor activity
TKWG_00535	COG0673	inositol 2-dehydrogenase activity
TKWG_00560	COG0590	tRNA wobble adenosine to inosine editing
TKWG_00565	COG2807	transmembrane transport
TKWG_00575	COG0583	DNA-binding transcription factor activity
TKWG_00585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TKWG_00595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TKWG_00605	COG0596	Alpha beta hydrolase
TKWG_00610	COG0596	Alpha beta hydrolase
TKWG_00615	COG2309	aminopeptidase activity
TKWG_00620	COG1335	isochorismatase
TKWG_00625	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
TKWG_00635	COG0446	pyridine nucleotide-disulphide oxidoreductase
TKWG_00640	COG2146	nitrite reductase [NAD(P)H] activity
TKWG_00645	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TKWG_00715	COG3473	Maleate cis-trans isomerase
TKWG_00725	COG1487	ribonuclease activity
TKWG_00745	COG3755	Protein conserved in bacteria
TKWG_00755	COG3237	CsbD-like
TKWG_00765	COG1546	Belongs to the CinA family
TKWG_00785	COG1573	uracil-dna glycosylase
TKWG_00790	COG1280	lysine exporter protein (LysE YggA)
TKWG_00805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKWG_00840	COG0861	Integral membrane protein TerC family
TKWG_00870	COG2706	6-phosphogluconolactonase activity
TKWG_00935	COG4771	TonB-dependent receptor
TKWG_00980	COG2211	Major facilitator Superfamily
TKWG_01045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TKWG_01045	COG2010	Cytochrome c
TKWG_01055	COG0683	leucine binding
TKWG_01065	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKWG_01075	COG0411	ABC transporter
TKWG_01080	COG0410	ABC transporter
TKWG_01100	COG0596	Alpha beta hydrolase
TKWG_01105	COG2309	aminopeptidase activity
TKWG_01110	COG1335	isochorismatase
TKWG_01115	COG1309	transcriptional regulator
TKWG_01175	COG1230	cation diffusion facilitator family transporter
TKWG_01205	COG0583	DNA-binding transcription factor activity
TKWG_01210	COG2910	NAD(P)H-binding
TKWG_01230	COG2223	nitrite transmembrane transporter activity
TKWG_01235	COG2223	nitrite transmembrane transporter activity
TKWG_01255	COG5383	Protein conserved in bacteria
TKWG_01270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKWG_01275	COG4605	iron ion homeostasis
TKWG_01280	COG4604	ABC transporter, ATP-binding protein
TKWG_01300	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_01305	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_01320	COG3284	Transcriptional regulator
TKWG_01325	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_01340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TKWG_01350	COG3608	succinylglutamate desuccinylase aspartoacylase
TKWG_01350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TKWG_01355	COG2010	Cytochrome c
TKWG_01365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TKWG_01405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TKWG_01425	COG0024	Methionine aminopeptidase
TKWG_01430	COG0024	Methionine aminopeptidase
TKWG_01445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TKWG_01460	COG3189	MarR family transcriptional regulator
TKWG_01470	COG4993	Dehydrogenase
TKWG_01480	COG4772	TonB-dependent receptor
TKWG_01485	COG4772	TonB-dependent receptor
TKWG_01490	COG1335	isochorismatase
TKWG_01500	COG1414	Transcriptional regulator
TKWG_01515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_01530	COG1560	Kdo2-lipid A biosynthetic process
TKWG_01580	COG0583	DNA-binding transcription factor activity
TKWG_01600	COG1131	(ABC) transporter
TKWG_01605	COG1131	(ABC) transporter
TKWG_01610	COG0842	Transport permease protein
TKWG_01630	COG4176	ABC-type proline glycine betaine transport system permease component
TKWG_01650	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_01655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_01675	COG2129	metallophosphoesterase
TKWG_01695	COG1247	-acetyltransferase
TKWG_01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_01715	COG0601	transmembrane transport
TKWG_01720	COG4608	Belongs to the ABC transporter superfamily
TKWG_01730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKWG_01765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TKWG_01770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TKWG_01775	COG2161	toxin-antitoxin pair type II binding
TKWG_01780	COG4115	mRNA cleavage
TKWG_01785	COG3501	Rhs element vgr protein
TKWG_01795	COG3501	Rhs element vgr protein
TKWG_01875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TKWG_01880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TKWG_01885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TKWG_01900	COG1414	Transcriptional regulator
TKWG_01905	COG1024	Enoyl-CoA hydratase
TKWG_01920	COG1960	acyl-CoA dehydrogenase activity
TKWG_01925	COG1960	acyl-CoA dehydrogenase activity
TKWG_01940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKWG_01945	COG3422	double-strand break repair
TKWG_01955	COG5339	Protein conserved in bacteria
TKWG_01970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TKWG_01975	COG0028	Belongs to the TPP enzyme family
TKWG_01980	COG2072	flavoprotein involved in K transport
TKWG_01985	COG2072	flavoprotein involved in K transport
TKWG_01990	COG0601	transmembrane transport
TKWG_01995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_02000	COG0444	Belongs to the ABC transporter superfamily
TKWG_02005	COG4608	Belongs to the ABC transporter superfamily
TKWG_02010	COG0747	negative chemotaxis
TKWG_02020	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_02030	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TKWG_02040	COG3433	isochorismatase activity
TKWG_02040	COG2226	methyltransferase
TKWG_02085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TKWG_02110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TKWG_02125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TKWG_02150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TKWG_02155	COG0183	Belongs to the thiolase family
TKWG_02190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_02210	COG1960	acyl-CoA dehydrogenase activity
TKWG_02230	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_02245	COG1024	Enoyl-CoA hydratase
TKWG_02250	COG2188	Transcriptional regulator
TKWG_02255	COG1280	lysine exporter protein (LysE YggA)
TKWG_02275	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TKWG_02285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TKWG_02325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKWG_02340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TKWG_02350	COG2193	ferroxidase activity
TKWG_02380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TKWG_02405	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TKWG_02410	COG1160	GTP binding
TKWG_02440	COG0697	spore germination
TKWG_02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKWG_02480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TKWG_02480	COG0678	peroxiredoxin activity
TKWG_02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_02510	COG4215	(ABC) transporter
TKWG_02515	COG4160	amino acid transport
TKWG_02520	COG4160	amino acid transport
TKWG_02550	COG3045	CreA protein
TKWG_02560	COG0405	Gamma-glutamyltransferase
TKWG_02565	COG2070	2-Nitropropane dioxygenase
TKWG_02590	COG0778	Nitroreductase
TKWG_02600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKWG_02605	COG1116	anion transmembrane transporter activity
TKWG_02615	COG2175	clavaminate synthase activity
TKWG_02620	COG1741	Belongs to the pirin family
TKWG_02665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TKWG_02675	COG2271	Major facilitator Superfamily
TKWG_02680	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_02685	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_02690	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_02695	COG1414	Transcriptional regulator
TKWG_02725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_02760	COG2009	succinate dehydrogenase
TKWG_02780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TKWG_02805	COG3038	cytochrome b561
TKWG_02860	COG2070	2-Nitropropane dioxygenase
TKWG_02865	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_02895	COG1335	isochorismatase
TKWG_02910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_02915	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_02920	COG0604	alcohol dehydrogenase
TKWG_02925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TKWG_02930	COG1522	sequence-specific DNA binding
TKWG_02945	COG0463	Glycosyl transferase, family 2
TKWG_02960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TKWG_02970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TKWG_02975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TKWG_03020	COG0109	protoheme IX farnesyltransferase activity
TKWG_03025	COG1999	signal sequence binding
TKWG_03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TKWG_03065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TKWG_03070	COG0513	Belongs to the DEAD box helicase family
TKWG_03100	COG1127	ABC transporter
TKWG_03105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TKWG_03110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TKWG_03135	COG1131	(ABC) transporter
TKWG_03140	COG0842	Transport permease protein
TKWG_03145	COG0271	Belongs to the BolA IbaG family
TKWG_03150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKWG_03155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TKWG_03160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TKWG_03165	COG0131	Imidazoleglycerol-phosphate dehydratase
TKWG_03170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TKWG_03175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TKWG_03180	COG0107	imidazoleglycerol-phosphate synthase activity
TKWG_03185	COG0107	imidazoleglycerol-phosphate synthase activity
TKWG_03190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TKWG_03195	COG0140	phosphoribosyl-ATP diphosphatase activity
TKWG_03200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TKWG_03210	COG0805	protein transport
TKWG_03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKWG_03225	COG1970	mechanosensitive ion channel activity
TKWG_03230	COG0723	plastoquinol--plastocyanin reductase activity
TKWG_03245	COG2857	Cytochrome c1
TKWG_03250	COG0625	glutathione transferase activity
TKWG_03255	COG2969	positive regulation of protein catabolic process
TKWG_03260	COG2096	Adenosyltransferase
TKWG_03270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TKWG_03275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TKWG_03280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TKWG_03285	COG0523	cobalamin synthesis protein
TKWG_03290	COG0735	belongs to the Fur family
TKWG_03300	COG1121	(ABC) transporter
TKWG_03305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TKWG_03315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TKWG_03325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TKWG_03330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TKWG_03335	COG1560	Kdo2-lipid A biosynthetic process
TKWG_03340	COG2076	Multidrug Resistance protein
TKWG_03360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TKWG_03365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TKWG_03370	COG1950	PFAM Membrane protein of
TKWG_03375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TKWG_03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TKWG_03390	COG0617	tRNA 3'-terminal CCA addition
TKWG_03430	COG0513	Belongs to the DEAD box helicase family
TKWG_03445	COG0134	indole-3-glycerol-phosphate synthase activity
TKWG_03460	COG0512	Glutamine amidotransferase of anthranilate synthase
TKWG_03470	COG0546	phosphoglycolate phosphatase activity
TKWG_03480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TKWG_03485	COG2967	ApaG domain
TKWG_03510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TKWG_03520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TKWG_03530	COG2823	Periplasmic or secreted lipoprotein
TKWG_03535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TKWG_03540	COG0792	nuclease activity
TKWG_03555	COG1660	Displays ATPase and GTPase activities
TKWG_03560	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TKWG_03570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TKWG_03575	COG1137	ATPase activity
TKWG_03590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TKWG_03615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TKWG_03620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TKWG_03625	COG1238	metal cluster binding
TKWG_03635	COG1984	allophanate hydrolase subunit 2
TKWG_03640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TKWG_03645	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_03670	COG5002	protein histidine kinase activity
TKWG_03685	COG2226	methyltransferase
TKWG_03730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TKWG_03755	COG0351	phosphomethylpyrimidine kinase
TKWG_03760	COG2326	polyphosphate kinase activity
TKWG_03775	COG0791	NLP P60 protein
TKWG_03780	COG1902	pentaerythritol trinitrate reductase activity
TKWG_03785	COG1902	pentaerythritol trinitrate reductase activity
TKWG_03795	COG1446	asparaginase
TKWG_03810	COG0747	negative chemotaxis
TKWG_03815	COG0601	transmembrane transport
TKWG_03820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_03850	COG1794	racemase activity, acting on amino acids and derivatives
TKWG_03870	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_03920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TKWG_03925	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TKWG_03940	COG2188	Transcriptional regulator
TKWG_03945	COG3624	Phosphonate C-P lyase system protein PhnG
TKWG_03955	COG3626	phosphonate metabolism
TKWG_03960	COG3627	carbon phosphorus lyase activity
TKWG_03975	COG4778	phosphonate C-P lyase system protein PhnL
TKWG_03980	COG3454	Phosphonate metabolism
TKWG_03995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TKWG_04035	COG0668	transmembrane transport
TKWG_04040	COG0668	transmembrane transport
TKWG_04065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_04070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TKWG_04100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TKWG_04110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKWG_04115	COG0473	3-isopropylmalate dehydrogenase activity
TKWG_04120	COG0252	asparaginase activity
TKWG_04125	COG0667	Aldo Keto reductase
TKWG_04130	COG3284	Transcriptional regulator
TKWG_04145	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
TKWG_04150	COG4647	ligase activity
TKWG_04155	COG2610	gluconate transmembrane transporter activity
TKWG_04170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TKWG_04265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_04280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TKWG_04280	COG0506	proline dehydrogenase activity
TKWG_04280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TKWG_04295	COG1956	GAF domain-containing protein
TKWG_04300	COG1956	GAF domain-containing protein
TKWG_04315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TKWG_04320	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_04330	COG3093	addiction module antidote protein HigA
TKWG_04340	COG2321	neutral zinc metallopeptidase
TKWG_04345	COG1994	Peptidase M50
TKWG_04350	COG3568	Endonuclease Exonuclease Phosphatase
TKWG_04380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TKWG_04385	COG2945	thiolester hydrolase activity
TKWG_04390	COG1686	Belongs to the peptidase S11 family
TKWG_04400	COG2921	Belongs to the UPF0250 family
TKWG_04405	COG0321	lipoyl(octanoyl) transferase activity
TKWG_04410	COG0321	lipoyl(octanoyl) transferase activity
TKWG_04415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TKWG_04420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TKWG_04425	COG0438	transferase activity, transferring glycosyl groups
TKWG_04440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TKWG_04445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TKWG_04450	COG0438	transferase activity, transferring glycosyl groups
TKWG_04500	COG1946	Acyl-CoA thioesterase
TKWG_04515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TKWG_04570	COG0095	Lipoate-protein ligase
TKWG_04580	COG0242	peptide deformylase activity
TKWG_04585	COG0758	DNA mediated transformation
TKWG_04590	COG0431	NADPH-dependent FMN reductase
TKWG_04620	COG0546	phosphoglycolate phosphatase activity
TKWG_04630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TKWG_04630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TKWG_04650	COG2204	response regulator
TKWG_04655	COG0569	domain protein
TKWG_04675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TKWG_04680	COG0010	Belongs to the arginase family
TKWG_04695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_04700	COG1414	Transcriptional regulator
TKWG_04705	COG1040	competence protein
TKWG_04715	COG2226	methyltransferase
TKWG_04730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TKWG_04735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TKWG_04750	COG0588	phosphoglycerate mutase activity
TKWG_04760	COG4942	peptidase
TKWG_04780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TKWG_04795	COG1024	Enoyl-CoA hydratase
TKWG_04805	COG0356	it plays a direct role in the translocation of protons across the membrane
TKWG_04815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TKWG_04820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TKWG_04825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TKWG_04830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TKWG_04835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TKWG_04840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TKWG_04845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TKWG_04855	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_04880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TKWG_04900	COG3245	cytochrome
TKWG_04920	COG5265	(ABC) transporter
TKWG_04930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TKWG_04950	COG0583	DNA-binding transcription factor activity
TKWG_04965	COG4977	sequence-specific DNA binding
TKWG_04965	COG1917	Cupin 2, conserved barrel domain protein
TKWG_05055	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_05080	COG0601	transmembrane transport
TKWG_05085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_05095	COG4172	Belongs to the ABC transporter superfamily
TKWG_05120	COG0154	amidase activity
TKWG_05125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_05145	COG0477	Major facilitator Superfamily
TKWG_05180	COG2186	Transcriptional regulator
TKWG_05185	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_05190	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_05215	COG1609	Transcriptional regulator
TKWG_05220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_05245	COG1850	ribulose-bisphosphate carboxylase activity
TKWG_05255	COG3360	Dodecin
TKWG_05280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_05305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TKWG_05310	COG0765	amino acid transport
TKWG_05315	COG0765	amino acid transport
TKWG_05320	COG1126	abc transporter atp-binding protein
TKWG_05435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_05445	COG0765	amino acid transport
TKWG_05450	COG1126	abc transporter atp-binding protein
TKWG_05460	COG0583	DNA-binding transcription factor activity
TKWG_05475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_05495	COG1024	Enoyl-CoA hydratase
TKWG_05510	COG1024	Enoyl-CoA hydratase
TKWG_05515	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_05530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_05565	COG1177	transmembrane transport
TKWG_05570	COG1176	ABC-type spermidine putrescine transport system, permease component I
TKWG_05575	COG3842	ATPase activity
TKWG_05610	COG0583	DNA-binding transcription factor activity
TKWG_05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_05655	COG4215	(ABC) transporter
TKWG_05660	COG4160	amino acid transport
TKWG_05665	COG4598	ABC transporter
TKWG_05680	COG2918	glutathione biosynthetic process
TKWG_05685	COG2918	glutathione biosynthetic process
TKWG_05690	COG2918	glutathione biosynthetic process
TKWG_05710	COG2813	Specifically methylates the guanine in position
TKWG_05710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TKWG_05715	COG2223	nitrite transmembrane transporter activity
TKWG_05725	COG2010	Cytochrome c
TKWG_05750	COG2259	Doxx family
TKWG_05755	COG0583	DNA-binding transcription factor activity
TKWG_05770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TKWG_05785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TKWG_05800	COG1792	Involved in formation and maintenance of cell shape
TKWG_05810	COG0768	penicillin binding
TKWG_05815	COG0772	Belongs to the SEDS family
TKWG_05820	COG0772	Belongs to the SEDS family
TKWG_05825	COG1194	a g-specific adenine glycosylase
TKWG_05830	COG2177	Part of the ABC transporter FtsEX involved in
TKWG_05835	COG2884	Cell division ATP-binding protein ftsE
TKWG_05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_05845	COG4597	amino acid ABC transporter
TKWG_05865	COG1126	abc transporter atp-binding protein
TKWG_05875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TKWG_05880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TKWG_05885	COG2197	response regulator
TKWG_05900	COG0237	dephospho-CoA kinase activity
TKWG_05905	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TKWG_05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TKWG_05920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TKWG_05925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TKWG_05930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TKWG_05950	COG1045	serine acetyltransferase
TKWG_05970	COG0142	geranyltranstransferase activity
TKWG_05975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_05980	COG0765	amino acid transport
TKWG_05985	COG1126	abc transporter atp-binding protein
TKWG_05990	COG0129	dihydroxy-acid dehydratase activity
TKWG_06010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TKWG_06015	COG3707	response regulator
TKWG_06020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TKWG_06035	COG1116	anion transmembrane transporter activity
TKWG_06040	COG1116	anion transmembrane transporter activity
TKWG_06045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TKWG_06050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TKWG_06075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TKWG_06080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TKWG_06085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TKWG_06085	COG1648	precorrin-2 dehydrogenase activity
TKWG_06095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TKWG_06100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TKWG_06115	COG1309	transcriptional regulator
TKWG_06130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TKWG_06135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TKWG_06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TKWG_06145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TKWG_06170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TKWG_06175	COG0352	thiamine-phosphate diphosphorylase activity
TKWG_06180	COG0351	phosphomethylpyrimidine kinase
TKWG_06185	COG1773	rubredoxin
TKWG_06190	COG1678	Uncharacterized ACR, COG1678
TKWG_06195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TKWG_06200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TKWG_06205	COG0540	Belongs to the ATCase OTCase family
TKWG_06210	COG0540	Belongs to the ATCase OTCase family
TKWG_06230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TKWG_06250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TKWG_06255	COG0557	exoribonuclease II activity
TKWG_06260	COG3150	esterase
TKWG_06265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TKWG_06270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TKWG_06275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKWG_06280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TKWG_06285	COG0511	ligase activity, forming carbon-carbon bonds
TKWG_06290	COG0511	ligase activity, forming carbon-carbon bonds
TKWG_06325	COG0762	integral membrane protein
TKWG_06355	COG1042	CoA-binding domain protein
TKWG_06355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TKWG_06355	COG0045	succinate-CoA ligase (ADP-forming) activity
TKWG_06365	COG3028	Belongs to the UPF0307 family
TKWG_06380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TKWG_06385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TKWG_06390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TKWG_06410	COG0316	Belongs to the HesB IscA family
TKWG_06415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TKWG_06420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TKWG_06440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TKWG_06445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TKWG_06445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TKWG_06450	COG0307	riboflavin synthase, alpha
TKWG_06460	COG3657	addiction module killer protein
TKWG_06465	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TKWG_06490	COG2837	iron assimilation
TKWG_06520	COG1999	signal sequence binding
TKWG_06565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TKWG_06570	COG0252	asparaginase activity
TKWG_06585	COG5487	UPF0391 membrane protein
TKWG_06590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TKWG_06590	COG0475	glutathione-regulated potassium exporter activity
TKWG_06630	COG1280	lysine exporter protein (LysE YggA)
TKWG_06640	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_06650	COG0129	dihydroxy-acid dehydratase activity
TKWG_06655	COG0583	DNA-binding transcription factor activity
TKWG_06670	COG0039	L-malate dehydrogenase activity
TKWG_06680	COG3501	Rhs element vgr protein
TKWG_06715	COG5507	3-demethylubiquinone-9 3-methyltransferase
TKWG_06735	COG0328	RNA-DNA hybrid ribonuclease activity
TKWG_06740	COG2226	methyltransferase
TKWG_06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TKWG_06750	COG0741	lytic transglycosylase activity
TKWG_06750	COG1388	LysM domain
TKWG_06765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TKWG_06770	COG0463	Glycosyl transferase, family 2
TKWG_06790	COG0589	response to stress
TKWG_06795	COG0642	Histidine kinase
TKWG_06800	COG0745	RESPONSE REGULATOR receiver
TKWG_06815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TKWG_06835	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TKWG_06850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TKWG_06855	COG0746	molybdenum cofactor guanylyltransferase activity
TKWG_06860	COG0303	'Molybdopterin
TKWG_06865	COG0303	'Molybdopterin
TKWG_06870	COG0303	'Molybdopterin
TKWG_06875	COG0521	Mo-molybdopterin cofactor biosynthetic process
TKWG_06880	COG0314	molybdopterin synthase activity
TKWG_06890	COG0315	cyclic pyranopterin monophosphate synthase activity
TKWG_06895	COG0678	peroxiredoxin activity
TKWG_06900	COG0477	Major facilitator Superfamily
TKWG_06920	COG0697	spore germination
TKWG_06925	COG0697	spore germination
TKWG_06930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TKWG_06935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_06940	COG4215	(ABC) transporter
TKWG_06955	COG0494	nUDIX hydrolase
TKWG_06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TKWG_06970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TKWG_06975	COG2721	sulfolactate sulfo-lyase activity
TKWG_06980	COG2186	Transcriptional regulator
TKWG_06985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TKWG_06990	COG3443	Belongs to the bacterial solute-binding protein 9 family
TKWG_07040	COG0587	DNA-directed DNA polymerase activity
TKWG_07045	COG0587	DNA-directed DNA polymerase activity
TKWG_07050	COG0587	DNA-directed DNA polymerase activity
TKWG_07055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TKWG_07060	COG4535	Mg2 and Co2 transporter CorC
TKWG_07065	COG4535	Mg2 and Co2 transporter CorC
TKWG_07070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TKWG_07075	COG1702	phosphate starvation-inducible protein PhoH
TKWG_07080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TKWG_07090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKWG_07100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKWG_07105	COG1862	Preprotein translocase
TKWG_07110	COG0343	queuine tRNA-ribosyltransferase activity
TKWG_07115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TKWG_07135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TKWG_07155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TKWG_07190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TKWG_07195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TKWG_07200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TKWG_07205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TKWG_07210	COG0126	phosphoglycerate kinase activity
TKWG_07240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TKWG_07260	COG0521	Mo-molybdopterin cofactor biosynthetic process
TKWG_07290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TKWG_07295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TKWG_07300	COG0009	L-threonylcarbamoyladenylate synthase
TKWG_07305	COG1473	amidohydrolase
TKWG_07335	COG0415	Belongs to the DNA photolyase family
TKWG_07340	COG1309	transcriptional regulator
TKWG_07355	COG1021	2,3-dihydroxybenzoate-AMP ligase
TKWG_07370	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_07385	COG2267	carboxylic ester hydrolase activity
TKWG_07400	COG1396	sequence-specific DNA binding
TKWG_07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_07410	COG0765	amino acid transport
TKWG_07415	COG1126	abc transporter atp-binding protein
TKWG_07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_07425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_07435	COG1490	D-aminoacyl-tRNA deacylase activity
TKWG_07450	COG1346	cytolysis
TKWG_07465	COG3836	Belongs to the HpcH HpaI aldolase family
TKWG_07495	COG0412	Dienelactone hydrolase
TKWG_07500	COG2989	Protein conserved in bacteria
TKWG_07505	COG3108	Peptidase M15
TKWG_07510	COG1250	3-hydroxyacyl-CoA dehydrogenase
TKWG_07520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TKWG_07525	COG3246	L-lysine catabolic process to acetate
TKWG_07580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TKWG_07600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_07605	COG0765	amino acid transport
TKWG_07610	COG0765	amino acid transport
TKWG_07620	COG1802	Transcriptional regulator
TKWG_07625	COG0439	Biotin carboxylase
TKWG_07630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TKWG_07640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_07650	COG0825	malonyl-CoA metabolic process
TKWG_07660	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
TKWG_07690	COG3237	CsbD-like
TKWG_07735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TKWG_07745	COG0859	PFAM glycosyl transferase family 9
TKWG_07760	COG2192	nodulation
TKWG_07830	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_07840	COG2030	dehydratase
TKWG_07845	COG0831	urea catabolic process
TKWG_07850	COG0832	Belongs to the urease beta subunit family
TKWG_07865	COG0829	nickel cation binding
TKWG_07870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TKWG_07920	COG3121	Chaperone
TKWG_07925	COG3539	Fimbrial protein
TKWG_07940	COG0579	oxidoreductase
TKWG_07945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_07955	COG0259	pyridoxamine-phosphate oxidase activity
TKWG_07960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
TKWG_07965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TKWG_07990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TKWG_08000	COG1215	transferase activity, transferring glycosyl groups
TKWG_08010	COG0488	(ABC) transporter
TKWG_08025	COG0488	(ABC) transporter
TKWG_08040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TKWG_08045	COG2894	cell division
TKWG_08100	COG0745	RESPONSE REGULATOR receiver
TKWG_08110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TKWG_08140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TKWG_08145	COG1929	Belongs to the glycerate kinase type-1 family
TKWG_08150	COG1929	Belongs to the glycerate kinase type-1 family
TKWG_08155	COG1929	Belongs to the glycerate kinase type-1 family
TKWG_08170	COG0469	pyruvate kinase activity
TKWG_08175	COG0346	lactoylglutathione lyase activity
TKWG_08185	COG0204	Acyl-transferase
TKWG_08190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TKWG_08195	COG0751	glycine-tRNA ligase activity
TKWG_08200	COG0752	glycyl-tRNA synthetase alpha subunit
TKWG_08250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_08255	COG0444	Belongs to the ABC transporter superfamily
TKWG_08260	COG4608	Belongs to the ABC transporter superfamily
TKWG_08270	COG0617	tRNA 3'-terminal CCA addition
TKWG_08295	COG0628	permease
TKWG_08310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TKWG_08325	COG0860	N-Acetylmuramoyl-L-alanine amidase
TKWG_08330	COG0802	atpase or kinase
TKWG_08340	COG4974	Belongs to the 'phage' integrase family
TKWG_08375	COG1522	sequence-specific DNA binding
TKWG_08430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TKWG_08435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TKWG_08455	COG0505	Belongs to the CarA family
TKWG_08460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TKWG_08470	COG0300	oxidoreductase activity
TKWG_08475	COG0406	alpha-ribazole phosphatase activity
TKWG_08495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TKWG_08505	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TKWG_08510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TKWG_08525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TKWG_08540	COG0248	Ppx GppA phosphatase
TKWG_08575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TKWG_08585	COG0789	Transcriptional regulator
TKWG_08595	COG2217	Heavy metal translocating P-type atpase
TKWG_08610	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TKWG_08655	COG1404	Belongs to the peptidase S8 family
TKWG_08735	COG0671	phosphoesterase, PA-phosphatase related
TKWG_08795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TKWG_08800	COG2080	2 iron, 2 sulfur cluster binding
TKWG_08860	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_08865	COG2030	dehydratase
TKWG_08865	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_08895	COG5002	protein histidine kinase activity
TKWG_08900	COG1132	(ABC) transporter
TKWG_08925	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_08945	COG2863	cytochrome
TKWG_08950	COG0642	Histidine kinase
TKWG_08955	COG0745	RESPONSE REGULATOR receiver
TKWG_08960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TKWG_08985	COG2010	Cytochrome c
TKWG_09050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKWG_09095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TKWG_09115	COG0640	Transcriptional regulator
TKWG_09145	COG1024	Enoyl-CoA hydratase
TKWG_09150	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_09180	COG0583	DNA-binding transcription factor activity
TKWG_09200	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_09205	COG0028	Belongs to the TPP enzyme family
TKWG_09210	COG3119	arylsulfatase activity
TKWG_09220	COG0583	DNA-binding transcription factor activity
TKWG_09225	COG2249	NAD(P)H dehydrogenase (quinone) activity
TKWG_09230	COG1733	regulation of RNA biosynthetic process
TKWG_09240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TKWG_09250	COG1414	Transcriptional regulator
TKWG_09265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TKWG_09290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_09315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_09325	COG2814	Major facilitator Superfamily
TKWG_09330	COG0659	secondary active sulfate transmembrane transporter activity
TKWG_09345	COG0745	RESPONSE REGULATOR receiver
TKWG_09355	COG0149	triose-phosphate isomerase activity
TKWG_09360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKWG_09365	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
TKWG_09370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_09375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKWG_09380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKWG_09385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKWG_09390	COG0649	NAD binding
TKWG_09405	COG1034	ATP synthesis coupled electron transport
TKWG_09420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKWG_09430	COG0713	ATP synthesis coupled electron transport
TKWG_09455	COG1007	ATP synthesis coupled electron transport
TKWG_09485	COG0625	glutathione transferase activity
TKWG_09490	COG0560	Phosphoserine phosphatase
TKWG_09495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TKWG_09520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKWG_09525	COG0450	alkyl hydroperoxide reductase
TKWG_09540	COG0745	RESPONSE REGULATOR receiver
TKWG_09560	COG1573	uracil-dna glycosylase
TKWG_09565	COG2814	Major facilitator Superfamily
TKWG_09590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TKWG_09595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TKWG_09605	COG2917	probably involved in intracellular septation
TKWG_09610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TKWG_09625	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKWG_09640	COG0410	ABC transporter
TKWG_09660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TKWG_09665	COG2878	Part of a membrane complex involved in electron transport
TKWG_09690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TKWG_09695	COG0251	oxidation-reduction process
TKWG_09705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TKWG_09710	COG0133	tryptophan synthase activity
TKWG_09715	COG0159	tryptophan synthase activity
TKWG_09720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TKWG_09795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TKWG_09800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TKWG_09805	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TKWG_09810	COG3023	N-Acetylmuramoyl-L-alanine amidase
TKWG_09825	COG0424	maF-like protein
TKWG_09835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TKWG_09840	COG0416	fatty acid biosynthetic process
TKWG_09875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TKWG_09900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKWG_09910	COG0481	GTPase activity
TKWG_09915	COG0681	Belongs to the peptidase S26 family
TKWG_09920	COG0571	ribonuclease III activity
TKWG_09975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TKWG_09990	COG0583	DNA-binding transcription factor activity
TKWG_09995	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_10020	COG1024	Enoyl-CoA hydratase
TKWG_10020	COG1250	3-hydroxyacyl-CoA dehydrogenase
TKWG_10030	COG0183	Belongs to the thiolase family
TKWG_10035	COG1960	acyl-CoA dehydrogenase activity
TKWG_10050	COG0791	NLP P60 protein
TKWG_10055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TKWG_10065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TKWG_10095	COG1733	regulation of RNA biosynthetic process
TKWG_10100	COG2814	Major facilitator Superfamily
TKWG_10105	COG2363	Small membrane protein
TKWG_10120	COG2855	membrane
TKWG_10125	COG0583	DNA-binding transcription factor activity
TKWG_10130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TKWG_10140	COG2814	Major facilitator Superfamily
TKWG_10145	COG0534	Mate efflux family protein
TKWG_10160	COG0254	rRNA binding
TKWG_10170	COG3483	tryptophan 2,3-dioxygenase activity
TKWG_10180	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TKWG_10185	COG2003	Belongs to the UPF0758 family
TKWG_10210	COG0625	glutathione transferase activity
TKWG_10215	COG0424	maF-like protein
TKWG_10220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TKWG_10225	COG0799	negative regulation of ribosome biogenesis
TKWG_10230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TKWG_10235	COG0151	Belongs to the GarS family
TKWG_10245	COG0217	transcriptional regulatory protein
TKWG_10250	COG0433	COG0433 Predicted ATPase
TKWG_10280	COG0667	Aldo Keto reductase
TKWG_10285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TKWG_10310	COG0308	aminopeptidase N
TKWG_10330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TKWG_10345	COG0277	FAD linked oxidase domain protein
TKWG_10350	COG0247	lactate metabolic process
TKWG_10355	COG0482	sulfurtransferase activity
TKWG_10365	COG3909	cytochrome
TKWG_10390	COG0069	glutamate synthase activity
TKWG_10400	COG2134	cdp-diacylglycerol pyrophosphatase
TKWG_10415	COG2732	(Barnase) inhibitor
TKWG_10425	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
TKWG_10430	COG2323	membrane
TKWG_10480	COG2951	lytic endotransglycosylase activity
TKWG_10520	COG1091	dTDP-4-dehydrorhamnose reductase activity
TKWG_10535	COG2885	chlorophyll binding
TKWG_10545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TKWG_10560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TKWG_10580	COG0287	Prephenate dehydrogenase
TKWG_10585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TKWG_10590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TKWG_10625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TKWG_10630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TKWG_10655	COG3278	Belongs to the heme-copper respiratory oxidase family
TKWG_10670	COG3278	Belongs to the heme-copper respiratory oxidase family
TKWG_10710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TKWG_10715	COG0410	ABC transporter
TKWG_10720	COG0411	ABC transporter
TKWG_10760	COG2841	Protein conserved in bacteria
TKWG_10765	COG0628	permease
TKWG_10775	COG3135	benzoate transporter
TKWG_10780	COG3135	benzoate transporter
TKWG_10785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TKWG_10800	COG0556	nucleotide-excision repair
TKWG_10820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TKWG_10825	COG2137	regulation of response to DNA damage stimulus
TKWG_10830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TKWG_10835	COG0583	DNA-binding transcription factor activity
TKWG_10865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TKWG_10870	COG0861	Integral membrane protein TerC family
TKWG_10875	COG0861	Integral membrane protein TerC family
TKWG_10880	COG0181	hydroxymethylbilane synthase activity
TKWG_10905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TKWG_10975	COG0425	Belongs to the sulfur carrier protein TusA family
TKWG_10980	COG0228	four-way junction DNA binding
TKWG_10985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TKWG_10990	COG0336	Belongs to the RNA methyltransferase TrmD family
TKWG_10995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TKWG_11000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKWG_11010	COG1104	cysteine desulfurase activity
TKWG_11015	COG0822	iron-sulfur transferase activity
TKWG_11020	COG0316	Belongs to the HesB IscA family
TKWG_11025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TKWG_11030	COG0443	Heat shock 70 kDa protein
TKWG_11035	COG0633	Ferredoxin
TKWG_11050	COG0604	alcohol dehydrogenase
TKWG_11115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TKWG_11130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TKWG_11140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TKWG_11145	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_11150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TKWG_11195	COG3047	cAMP biosynthetic process
TKWG_11195	COG2885	chlorophyll binding
TKWG_11210	COG1136	(ABC) transporter
TKWG_11215	COG0084	hydrolase, TatD family'
TKWG_11235	COG0613	PHP domain protein
TKWG_11250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TKWG_11255	COG0584	glycerophosphoryl diester phosphodiesterase
TKWG_11260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TKWG_11270	COG4181	ATPase activity
TKWG_11290	COG1758	RNA polymerase activity
TKWG_11295	COG0194	GDP metabolic process
TKWG_11300	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_11310	COG1561	YicC-like family, N-terminal region
TKWG_11315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TKWG_11320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TKWG_11325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TKWG_11340	COG3852	Histidine kinase
TKWG_11360	COG1178	ABC-type Fe3 transport system permease component
TKWG_11365	COG1840	ABC-type Fe3 transport system, periplasmic component
TKWG_11380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TKWG_11400	COG3842	ATPase activity
TKWG_11405	COG0395	ABC-type sugar transport system, permease component
TKWG_11450	COG0410	ABC transporter
TKWG_11465	COG1999	signal sequence binding
TKWG_11470	COG0339	signal peptide processing
TKWG_11475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TKWG_11505	COG0508	dehydrogenase complex catalyzes the overall conversion of
TKWG_11510	COG0508	dehydrogenase complex catalyzes the overall conversion of
TKWG_11515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKWG_11520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKWG_11525	COG0285	dihydrofolate synthase activity
TKWG_11550	COG2814	Major facilitator Superfamily
TKWG_11570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TKWG_11575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TKWG_11580	COG0024	Methionine aminopeptidase
TKWG_11585	COG0052	Belongs to the universal ribosomal protein uS2 family
TKWG_11590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TKWG_11595	COG0528	UMP kinase activity
TKWG_11600	COG0233	cytoplasmic translational termination
TKWG_11605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TKWG_11610	COG0575	Belongs to the CDS family
TKWG_11615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TKWG_11625	COG0750	zinc metalloprotease
TKWG_11640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TKWG_11655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TKWG_11660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TKWG_11665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TKWG_11675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKWG_11680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TKWG_11710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TKWG_11720	COG2914	Belongs to the UPF0125 (RnfH) family
TKWG_11725	COG1024	Enoyl-CoA hydratase
TKWG_11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
TKWG_11740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TKWG_11745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TKWG_11755	COG0084	hydrolase, TatD family'
TKWG_11780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKWG_11785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKWG_11790	COG0625	glutathione transferase activity
TKWG_11795	COG0386	Belongs to the glutathione peroxidase family
TKWG_11800	COG5006	permease, DMT superfamily
TKWG_11805	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_11815	COG0583	DNA-binding transcription factor activity
TKWG_11820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TKWG_11825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_11855	COG3386	PFAM SMP-30 Gluconolaconase
TKWG_11870	COG1129	ABC transporter
TKWG_11885	COG1802	Transcriptional regulator
TKWG_11900	COG1609	Transcriptional regulator
TKWG_11905	COG1609	Transcriptional regulator
TKWG_11920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TKWG_11980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TKWG_11985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TKWG_11995	COG1764	response to oxidative stress
TKWG_12000	COG0583	DNA-binding transcription factor activity
TKWG_12025	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_12035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKWG_12035	COG2111	Na H antiporter
TKWG_12040	COG2111	Na H antiporter
TKWG_12040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKWG_12045	COG2111	Na H antiporter
TKWG_12045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKWG_12050	COG1006	Multisubunit Na H antiporter MnhC subunit
TKWG_12070	COG2212	antiporter activity
TKWG_12095	COG0778	Nitroreductase
TKWG_12100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TKWG_12160	COG0183	Belongs to the thiolase family
TKWG_12175	COG1187	pseudouridine synthase activity
TKWG_12180	COG3161	chorismate lyase activity
TKWG_12185	COG0347	Belongs to the P(II) protein family
TKWG_12190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TKWG_12190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TKWG_12195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TKWG_12195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TKWG_12210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKWG_12240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TKWG_12245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TKWG_12250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TKWG_12255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TKWG_12260	COG2252	PERMEase
TKWG_12265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKWG_12285	COG1619	proteins homologs of microcin C7 resistance protein MccF
TKWG_12290	COG0590	tRNA wobble adenosine to inosine editing
TKWG_12310	COG1595	DNA-templated transcription, initiation
TKWG_12350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TKWG_12350	COG0519	Catalyzes the synthesis of GMP from XMP
TKWG_12375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKWG_12375	COG0047	phosphoribosylformylglycinamidine synthase activity
TKWG_12390	COG1686	Belongs to the peptidase S11 family
TKWG_12415	COG0210	DNA helicase
TKWG_12460	COG4608	Belongs to the ABC transporter superfamily
TKWG_12465	COG4608	Belongs to the ABC transporter superfamily
TKWG_12470	COG0601	transmembrane transport
TKWG_12485	COG0546	phosphoglycolate phosphatase activity
TKWG_12520	COG3959	Transketolase, thiamine diphosphate binding domain
TKWG_12525	COG1802	Transcriptional regulator
TKWG_12535	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_12580	COG0022	dehydrogenase e1 component
TKWG_12585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TKWG_12590	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_12595	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_12600	COG2186	Transcriptional regulator
TKWG_12610	COG1304	FMN binding
TKWG_12615	COG1304	FMN binding
TKWG_12625	COG0776	regulation of translation
TKWG_12640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TKWG_12645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TKWG_12650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TKWG_12660	COG2960	long-chain fatty acid transporting porin activity
TKWG_12675	COG0004	ammonium transporteR
TKWG_12690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKWG_12695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKWG_12705	COG0189	ligase activity
TKWG_12710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TKWG_12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TKWG_12750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TKWG_12765	COG0544	peptidyl-prolyl cis-trans isomerase activity
TKWG_12775	COG3258	Cytochrome c
TKWG_12780	COG2863	cytochrome
TKWG_12785	COG2863	cytochrome
TKWG_12810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TKWG_12820	COG0410	ABC transporter
TKWG_12825	COG0829	nickel cation binding
TKWG_12830	COG0831	urea catabolic process
TKWG_12840	COG0832	Belongs to the urease beta subunit family
TKWG_12845	COG0804	urea catabolic process
TKWG_12850	COG0804	urea catabolic process
TKWG_12860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TKWG_12870	COG1760	l-serine dehydratase
TKWG_12890	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TKWG_12915	COG1278	Cold shock
TKWG_12965	COG1126	abc transporter atp-binding protein
TKWG_12970	COG0765	amino acid transport
TKWG_12985	COG2721	sulfolactate sulfo-lyase activity
TKWG_13010	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_13025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_13055	COG1024	Enoyl-CoA hydratase
TKWG_13060	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_13070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TKWG_13105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TKWG_13110	COG0625	glutathione transferase activity
TKWG_13150	COG0582	viral genome integration into host DNA
TKWG_13155	COG3093	addiction module antidote protein HigA
TKWG_13195	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_13230	COG2135	peptidase activity
TKWG_13255	COG0582	viral genome integration into host DNA
TKWG_13380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TKWG_13410	COG0330	HflC and HflK could
TKWG_13415	COG0330	HflC and HflK could
TKWG_13420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TKWG_13425	COG1923	regulation of RNA biosynthetic process
TKWG_13430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TKWG_13465	COG0124	histidyl-tRNA synthetase
TKWG_13470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TKWG_13480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TKWG_13485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TKWG_13490	COG0105	UTP biosynthetic process
TKWG_13495	COG0525	valine-tRNA ligase activity
TKWG_13515	COG0656	L-ascorbic acid biosynthetic process
TKWG_13520	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_13545	COG5285	phytanoyl-CoA dioxygenase
TKWG_13550	COG0662	Cupin 2, conserved barrel domain protein
TKWG_13555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TKWG_13560	COG0456	acetyltransferase
TKWG_13575	COG2207	Transcriptional regulator
TKWG_13600	COG0583	DNA-binding transcription factor activity
TKWG_13620	COG0596	Alpha beta hydrolase
TKWG_13645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TKWG_13660	COG3119	arylsulfatase activity
TKWG_13665	COG0583	DNA-binding transcription factor activity
TKWG_13725	COG0730	response to heat
TKWG_13735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKWG_13775	COG1024	Enoyl-CoA hydratase
TKWG_13780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_13795	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_13830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TKWG_13845	COG0583	DNA-binding transcription factor activity
TKWG_13850	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_13875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TKWG_13890	COG0583	DNA-binding transcription factor activity
TKWG_13910	COG0673	inositol 2-dehydrogenase activity
TKWG_13930	COG1335	isochorismatase
TKWG_13935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TKWG_13965	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_13975	COG0589	response to stress
TKWG_13985	COG0625	glutathione transferase activity
TKWG_14000	COG2130	NADP-dependent
TKWG_14045	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_14050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKWG_14055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_14060	COG0583	DNA-binding transcription factor activity
TKWG_14085	COG0697	spore germination
TKWG_14090	COG1285	pathogenesis
TKWG_14105	COG0165	Argininosuccinate lyase
TKWG_14115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_14125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_14135	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_14230	COG2135	peptidase activity
TKWG_14240	COG1280	lysine exporter protein (LysE YggA)
TKWG_14260	COG0436	Aminotransferase
TKWG_14265	COG2171	N-acyltransferase activity
TKWG_14270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TKWG_14275	COG2890	protein-(glutamine-N5) methyltransferase activity
TKWG_14295	COG0135	phosphoribosylanthranilate isomerase activity
TKWG_14315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TKWG_14360	COG0066	3-isopropylmalate dehydratase activity
TKWG_14365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TKWG_14395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TKWG_14400	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TKWG_14440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TKWG_14445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TKWG_14460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TKWG_14465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TKWG_14470	COG0038	chloride channel
TKWG_14480	COG0038	chloride channel
TKWG_14495	COG0501	Belongs to the peptidase M48B family
TKWG_14530	COG2086	electron transfer activity
TKWG_14560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TKWG_14565	COG0322	excinuclease ABC activity
TKWG_14580	COG1472	Belongs to the glycosyl hydrolase 3 family
TKWG_14585	COG0736	holo-[acyl-carrier-protein] synthase activity
TKWG_14600	COG0501	Belongs to the peptidase M48B family
TKWG_14605	COG1162	GTPase activity
TKWG_14615	COG0494	nUDIX hydrolase
TKWG_14620	COG0335	large ribosomal subunit rRNA binding
TKWG_14635	COG0450	alkyl hydroperoxide reductase
TKWG_14640	COG1960	acyl-CoA dehydrogenase activity
TKWG_14685	COG0583	DNA-binding transcription factor activity
TKWG_14780	COG2070	2-Nitropropane dioxygenase
TKWG_14785	COG1671	Belongs to the UPF0178 family
TKWG_14855	COG1733	regulation of RNA biosynthetic process
TKWG_14895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TKWG_14900	COG0196	riboflavin kinase activity
TKWG_14905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TKWG_14910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TKWG_14925	COG0586	Pfam SNARE associated Golgi protein
TKWG_14965	COG2995	paraquat-inducible protein a
TKWG_14975	COG0542	response to heat
TKWG_14980	COG0542	response to heat
TKWG_14985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TKWG_14990	COG1278	Cold shock
TKWG_15005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TKWG_15030	COG1663	tetraacyldisaccharide 4'-kinase activity
TKWG_15035	COG2835	tetraacyldisaccharide 4'-kinase activity
TKWG_15040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TKWG_15045	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TKWG_15050	COG0563	adenylate kinase activity
TKWG_15080	COG0728	peptidoglycan biosynthetic process
TKWG_15085	COG0268	Binds directly to 16S ribosomal RNA
TKWG_15095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TKWG_15100	COG0137	argininosuccinate synthase activity
TKWG_15115	COG0642	Histidine kinase
TKWG_15120	COG0745	RESPONSE REGULATOR receiver
TKWG_15125	COG0419	ATPase involved in DNA repair
TKWG_15130	COG0419	ATPase involved in DNA repair
TKWG_15165	COG2354	Protein conserved in bacteria
TKWG_15170	COG0776	regulation of translation
TKWG_15185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKWG_15215	COG3094	Invasion gene expression up-regulator, SirB
TKWG_15220	COG2153	protein acetylation
TKWG_15225	COG4178	(ABC) transporter
TKWG_15230	COG1253	flavin adenine dinucleotide binding
TKWG_15235	COG1253	flavin adenine dinucleotide binding
TKWG_15240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TKWG_15245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TKWG_15250	COG4208	sulfate ABC transporter
TKWG_15270	COG2895	sulfate adenylyltransferase (ATP) activity
TKWG_15275	COG0175	sulfate reduction
TKWG_15315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKWG_15330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_15420	COG0859	PFAM glycosyl transferase family 9
TKWG_15430	COG1733	regulation of RNA biosynthetic process
TKWG_15435	COG1335	isochorismatase
TKWG_15440	COG0726	polysaccharide deacetylase
TKWG_15445	COG0438	transferase activity, transferring glycosyl groups
TKWG_15480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TKWG_15490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TKWG_15505	COG1177	transmembrane transport
TKWG_15510	COG1176	ABC-type spermidine putrescine transport system, permease component I
TKWG_15515	COG1176	ABC-type spermidine putrescine transport system, permease component I
TKWG_15530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TKWG_15540	COG2346	COG2346, Truncated hemoglobins
TKWG_15545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TKWG_15550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TKWG_15570	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_15575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TKWG_15580	COG1562	ergosterol biosynthetic process
TKWG_15595	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TKWG_15645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TKWG_15650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TKWG_15655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TKWG_15665	COG0305	Participates in initiation and elongation during chromosome replication
TKWG_15670	COG0359	binds to the 23S rRNA
TKWG_15675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TKWG_15680	COG2965	DNA replication, synthesis of RNA primer
TKWG_15685	COG0360	Binds together with S18 to 16S ribosomal RNA
TKWG_15710	COG0142	geranyltranstransferase activity
TKWG_15715	COG1722	exodeoxyribonuclease VII activity
TKWG_15755	COG0583	DNA-binding transcription factor activity
TKWG_15770	COG0583	DNA-binding transcription factor activity
TKWG_15785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKWG_15785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKWG_15790	COG1611	Belongs to the LOG family
TKWG_15800	COG2197	response regulator
TKWG_15825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TKWG_15850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TKWG_15860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TKWG_15875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TKWG_15880	COG0148	phosphopyruvate hydratase activity
TKWG_15885	COG0477	Major facilitator Superfamily
TKWG_15890	COG0477	Major facilitator Superfamily
TKWG_15900	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TKWG_15905	COG0504	CTP synthase activity
TKWG_15915	COG0662	Cupin 2, conserved barrel domain protein
TKWG_15930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TKWG_15935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TKWG_15940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TKWG_16015	COG1850	ribulose-bisphosphate carboxylase activity
TKWG_16025	COG0464	growth
TKWG_16030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKWG_16035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TKWG_16040	COG3954	Phosphoribulokinase
TKWG_16055	COG0191	fructose-bisphosphate aldolase activity
TKWG_16060	COG0191	fructose-bisphosphate aldolase activity
TKWG_16065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TKWG_16070	COG3791	Glutathione-dependent formaldehyde-activating
TKWG_16080	COG0596	Alpha beta hydrolase
TKWG_16090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TKWG_16095	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TKWG_16105	COG0535	radical SAM domain protein
TKWG_16130	COG0385	Bile acid
TKWG_16135	COG0456	acetyltransferase
TKWG_16155	COG1175	transmembrane transport
TKWG_16160	COG0395	ABC-type sugar transport system, permease component
TKWG_16175	COG3842	ATPase activity
TKWG_16185	COG2326	polyphosphate kinase activity
TKWG_16215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TKWG_16220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TKWG_16235	COG0195	Participates in both transcription termination and antitermination
TKWG_16235	COG2251	uridine kinase activity
TKWG_16240	COG0779	Required for maturation of 30S ribosomal subunits
TKWG_16245	COG1187	pseudouridine synthase activity
TKWG_16255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TKWG_16270	COG1522	sequence-specific DNA binding
TKWG_16295	COG0602	queuosine metabolic process
TKWG_16300	COG0720	synthase
TKWG_16305	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_16315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_16385	COG3237	CsbD-like
TKWG_16410	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TKWG_16415	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_16420	COG3243	poly(R)-hydroxyalkanoic acid synthase
TKWG_16430	COG0564	pseudouridine synthase activity
TKWG_16440	COG1199	ATP-dependent helicase activity
TKWG_16445	COG2183	response to ionizing radiation
TKWG_16465	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_16470	COG5265	(ABC) transporter
TKWG_16475	COG4608	Belongs to the ABC transporter superfamily
TKWG_16480	COG0444	Belongs to the ABC transporter superfamily
TKWG_16485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_16490	COG0601	transmembrane transport
TKWG_16500	COG0747	negative chemotaxis
TKWG_16505	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TKWG_16510	COG0180	Tryptophanyl-tRNA synthetase
TKWG_16515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TKWG_16520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKWG_16565	COG0372	Belongs to the citrate synthase family
TKWG_16570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TKWG_16575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TKWG_16580	COG1053	succinate dehydrogenase
TKWG_16585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TKWG_16670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TKWG_16685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TKWG_16695	COG1666	GTP binding
TKWG_16745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKWG_16765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TKWG_16765	COG4106	trans-aconitate 2-methyltransferase activity
TKWG_16770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TKWG_16820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TKWG_16835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_16845	COG1960	acyl-CoA dehydrogenase activity
TKWG_16860	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_16870	COG2159	amidohydrolase
TKWG_16880	COG0583	DNA-binding transcription factor activity
TKWG_16930	COG1024	Enoyl-CoA hydratase
TKWG_16955	COG1802	Transcriptional regulator
TKWG_16960	COG2271	Major facilitator Superfamily
TKWG_16970	COG0583	DNA-binding transcription factor activity
TKWG_16995	COG0037	tRNA processing
TKWG_17005	COG0825	malonyl-CoA metabolic process
TKWG_17040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TKWG_17045	COG1024	Enoyl-CoA hydratase
TKWG_17075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TKWG_17100	COG1253	flavin adenine dinucleotide binding
TKWG_17105	COG0583	DNA-binding transcription factor activity
TKWG_17110	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_17115	COG2030	dehydratase
TKWG_17145	COG0668	transmembrane transport
TKWG_17150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TKWG_17155	COG0679	Auxin Efflux Carrier
TKWG_17165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_17175	COG1335	isochorismatase
TKWG_17180	COG1126	abc transporter atp-binding protein
TKWG_17185	COG0765	amino acid transport
TKWG_17200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_17225	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_17235	COG2186	Transcriptional regulator
TKWG_17255	COG2850	peptidyl-arginine hydroxylation
TKWG_17260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TKWG_17265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TKWG_17270	COG0009	L-threonylcarbamoyladenylate synthase
TKWG_17295	COG0583	DNA-binding transcription factor activity
TKWG_17300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TKWG_17330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TKWG_17345	COG3193	protein, possibly involved in utilization of glycolate and propanediol
TKWG_17350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TKWG_17355	COG1185	polyribonucleotide nucleotidyltransferase activity
TKWG_17360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TKWG_17375	COG1183	phosphatidylcholine synthase activity
TKWG_17395	COG0765	amino acid transport
TKWG_17400	COG0765	amino acid transport
TKWG_17405	COG1126	abc transporter atp-binding protein
TKWG_17410	COG0183	Belongs to the thiolase family
TKWG_17415	COG0183	Belongs to the thiolase family
TKWG_17420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TKWG_17430	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_17435	COG0183	Belongs to the thiolase family
TKWG_17440	COG0183	Belongs to the thiolase family
TKWG_17455	COG1960	acyl-CoA dehydrogenase activity
TKWG_17465	COG1960	acyl-CoA dehydrogenase activity
TKWG_17470	COG2050	protein possibly involved in aromatic compounds catabolism
TKWG_17485	COG1024	Enoyl-CoA hydratase
TKWG_17495	COG1960	acyl-CoA dehydrogenase activity
TKWG_17500	COG1960	acyl-CoA dehydrogenase activity
TKWG_17535	COG1126	abc transporter atp-binding protein
TKWG_17540	COG0765	amino acid transport
TKWG_17545	COG0765	amino acid transport
TKWG_17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_17575	COG0436	Aminotransferase
TKWG_17580	COG0436	Aminotransferase
TKWG_17585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_17590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TKWG_17595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TKWG_17600	COG0440	acetolactate synthase activity
TKWG_17635	COG2271	Major facilitator Superfamily
TKWG_17640	COG3022	response to hydroperoxide
TKWG_17645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TKWG_17655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TKWG_17660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TKWG_17710	COG1053	succinate dehydrogenase
TKWG_17710	COG3976	FMN-binding domain protein
TKWG_17710	COG0431	NADPH-dependent FMN reductase
TKWG_17725	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_17730	COG0583	DNA-binding transcription factor activity
TKWG_17735	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_17745	COG0538	isocitrate dehydrogenase activity
TKWG_17775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TKWG_17800	COG3585	molybdate ion transport
TKWG_17800	COG2005	Transcriptional regulator
TKWG_17805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TKWG_17815	COG4149	molybdate abc transporter
TKWG_17820	COG0725	ABC transporter, periplasmic molybdate-binding protein
TKWG_17830	COG0484	heat shock protein binding
TKWG_17835	COG0443	Heat shock 70 kDa protein
TKWG_17840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TKWG_17850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TKWG_17855	COG1420	regulation of RNA biosynthetic process
TKWG_17860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TKWG_17875	COG0735	belongs to the Fur family
TKWG_17880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TKWG_17890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TKWG_17915	COG0477	Major facilitator Superfamily
TKWG_17930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TKWG_17935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TKWG_17945	COG1845	cytochrome c oxidase, subunit III
TKWG_17950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TKWG_17965	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TKWG_18010	COG0546	phosphoglycolate phosphatase activity
TKWG_18015	COG3842	ATPase activity
TKWG_18025	COG0395	ABC-type sugar transport system, permease component
TKWG_18030	COG1653	transport
TKWG_18050	COG1408	metallophosphoesterase
TKWG_18060	COG0531	amino acid
TKWG_18065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKWG_18070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_18095	COG2988	succinylglutamate desuccinylase activity
TKWG_18105	COG0583	DNA-binding transcription factor activity
TKWG_18110	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_18120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TKWG_18120	COG2169	Transcriptional regulator
TKWG_18155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TKWG_18170	COG2391	methyltransferase activity
TKWG_18190	COG3186	Phenylalanine-4-hydroxylase
TKWG_18195	COG2154	pterin-4-alpha-carbinolamine dehydratase
TKWG_18215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TKWG_18220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TKWG_18240	COG1414	Transcriptional regulator
TKWG_18260	COG0513	Belongs to the DEAD box helicase family
TKWG_18290	COG0429	hydrolase of the alpha beta-hydrolase fold
TKWG_18310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TKWG_18345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_18350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TKWG_18360	COG2255	four-way junction helicase activity
TKWG_18390	COG0514	ATP-dependent DNA helicase (RecQ)
TKWG_18415	COG2022	thiamine diphosphate biosynthetic process
TKWG_18450	COG1120	ATPase activity
TKWG_18455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKWG_18460	COG4558	Periplasmic binding protein
TKWG_18465	COG3720	iron ion transport
TKWG_18470	COG4771	TonB-dependent receptor
TKWG_18470	COG1629	transport
TKWG_18490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TKWG_18510	COG1742	UPF0060 membrane protein
TKWG_18520	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKWG_18530	COG1129	ABC transporter
TKWG_18535	COG1137	ATPase activity
TKWG_18620	COG1196	nuclear chromosome segregation
TKWG_18620	COG0741	lytic transglycosylase activity
TKWG_18620	COG0739	heme binding
TKWG_18630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TKWG_18650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TKWG_18665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TKWG_18705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKWG_18710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKWG_18715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TKWG_18735	COG3116	cell division
TKWG_18740	COG0275	rRNA processing
TKWG_18745	COG2001	Belongs to the MraZ family
TKWG_18765	COG0418	dihydroorotase activity
TKWG_18785	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_18790	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_18800	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_18835	COG4774	siderophore transport
TKWG_18840	COG1063	alcohol dehydrogenase
TKWG_18845	COG0477	Major facilitator Superfamily
TKWG_18850	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_18860	COG1609	Transcriptional regulator
TKWG_18910	COG1858	cytochrome C peroxidase
TKWG_18955	COG0437	4 iron, 4 sulfur cluster binding
TKWG_18960	COG0348	domain, Protein
TKWG_18990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TKWG_19000	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TKWG_19025	COG2084	Dehydrogenase
TKWG_19030	COG0494	nUDIX hydrolase
TKWG_19035	COG0442	prolyl-tRNA aminoacylation
TKWG_19040	COG0824	Thioesterase
TKWG_19050	COG0848	biopolymer transport protein
TKWG_19110	COG0586	Pfam SNARE associated Golgi protein
TKWG_19115	COG0586	Pfam SNARE associated Golgi protein
TKWG_19120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_19125	COG1120	ATPase activity
TKWG_19145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKWG_19155	COG0512	Glutamine amidotransferase of anthranilate synthase
TKWG_19155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TKWG_19165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TKWG_19175	COG1294	oxidase, subunit
TKWG_19200	COG0583	DNA-binding transcription factor activity
TKWG_19210	COG2814	Major facilitator Superfamily
TKWG_19215	COG0235	Class ii aldolase
TKWG_19235	COG0431	NADPH-dependent FMN reductase
TKWG_19240	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TKWG_19240	COG0778	Nitroreductase
TKWG_19260	COG1566	PFAM secretion protein HlyD family protein
TKWG_19310	COG1280	lysine exporter protein (LysE YggA)
TKWG_19330	COG0446	pyridine nucleotide-disulphide oxidoreductase
TKWG_19330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TKWG_19345	COG2186	Transcriptional regulator
TKWG_19350	COG0179	Fumarylacetoacetate (FAA) hydrolase
TKWG_19380	COG0477	Major facilitator Superfamily
TKWG_19395	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TKWG_19400	COG4172	Belongs to the ABC transporter superfamily
TKWG_19425	COG0747	negative chemotaxis
TKWG_19430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_19435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_19440	COG0028	Belongs to the TPP enzyme family
TKWG_19470	COG4176	ABC-type proline glycine betaine transport system permease component
TKWG_19480	COG3448	diguanylate cyclase activity
TKWG_19480	COG4175	Glycine betaine
TKWG_19505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TKWG_19510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_19515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_19530	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_19555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKWG_19560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKWG_19565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKWG_19570	COG1120	ATPase activity
TKWG_19620	COG0745	RESPONSE REGULATOR receiver
TKWG_19625	COG2205	protein histidine kinase activity
TKWG_19630	COG2205	protein histidine kinase activity
TKWG_19635	COG2205	protein histidine kinase activity
TKWG_19640	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TKWG_19655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TKWG_19660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TKWG_19665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TKWG_19675	COG0288	reversible hydration of carbon dioxide
TKWG_19680	COG0861	Integral membrane protein TerC family
TKWG_19685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKWG_19695	COG0019	diaminopimelate decarboxylase activity
TKWG_19710	COG1733	regulation of RNA biosynthetic process
TKWG_19715	COG0625	glutathione transferase activity
TKWG_19785	COG1335	isochorismatase
TKWG_19790	COG2309	aminopeptidase activity
TKWG_19795	COG0596	Alpha beta hydrolase
TKWG_19800	COG0596	Alpha beta hydrolase
TKWG_19815	COG2080	2 iron, 2 sulfur cluster binding
TKWG_19820	COG2010	Cytochrome c
TKWG_19820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TKWG_19825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TKWG_19825	COG2010	Cytochrome c
TKWG_19830	COG1846	Transcriptional regulator
TKWG_19895	COG0129	dihydroxy-acid dehydratase activity
TKWG_19910	COG0583	DNA-binding transcription factor activity
TKWG_19915	COG2076	Multidrug Resistance protein
TKWG_19975	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TKWG_19985	COG1396	sequence-specific DNA binding
TKWG_19985	COG3800	Transcriptional regulator
TKWG_20005	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_20020	COG1960	acyl-CoA dehydrogenase activity
TKWG_20030	COG4670	ketone body catabolic process
TKWG_20035	COG1024	Enoyl-CoA hydratase
TKWG_20040	COG3976	FMN-binding domain protein
TKWG_20040	COG1053	succinate dehydrogenase
TKWG_20060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_20075	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_20080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TKWG_20085	COG0459	protein refolding
TKWG_20115	COG0284	orotidine-5'-phosphate decarboxylase activity
TKWG_20120	COG0284	orotidine-5'-phosphate decarboxylase activity
TKWG_20125	COG1487	ribonuclease activity
TKWG_20130	COG4691	Plasmid stability protein
TKWG_20140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TKWG_20145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TKWG_20150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TKWG_20155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TKWG_20180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TKWG_20185	COG1960	acyl-CoA dehydrogenase activity
TKWG_20200	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_20205	COG1902	pentaerythritol trinitrate reductase activity
TKWG_20260	COG0742	ribosomal rna small subunit methyltransferase
TKWG_20265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TKWG_20270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKWG_20310	COG0346	lactoylglutathione lyase activity
TKWG_20320	COG0193	aminoacyl-tRNA hydrolase activity
TKWG_20325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TKWG_20330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TKWG_20335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TKWG_20425	COG0367	asparagine synthase
TKWG_20445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TKWG_20450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKWG_20460	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TKWG_20465	COG1765	OsmC-like protein
TKWG_20470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TKWG_20475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TKWG_20495	COG1737	Transcriptional regulator
TKWG_20500	COG3842	ATPase activity
TKWG_20505	COG1175	transmembrane transport
TKWG_20510	COG0395	ABC-type sugar transport system, permease component
TKWG_20525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKWG_20535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TKWG_20535	COG1796	DNA polymerase
TKWG_20555	COG0509	glycine decarboxylation via glycine cleavage system
TKWG_20575	COG2081	HI0933 family
TKWG_20590	COG0717	Belongs to the dCTP deaminase family
TKWG_20630	COG0489	protein tyrosine kinase activity
TKWG_20655	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_20680	COG1902	pentaerythritol trinitrate reductase activity
TKWG_20705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKWG_20705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKWG_20715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TKWG_20725	COG1652	LysM domain
TKWG_20765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TKWG_20775	COG3023	N-Acetylmuramoyl-L-alanine amidase
TKWG_20850	COG1396	sequence-specific DNA binding
TKWG_20965	COG3501	Rhs element vgr protein
TKWG_20970	COG2207	Transcriptional regulator
TKWG_20985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TKWG_21020	COG0640	Transcriptional regulator
TKWG_21030	COG2207	Transcriptional regulator
TKWG_21065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TKWG_21085	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_21090	COG1309	transcriptional regulator
TKWG_21175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TKWG_21180	COG1737	Transcriptional regulator
TKWG_21190	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TKWG_21220	COG1715	Restriction endonuclease
TKWG_21235	COG3119	arylsulfatase activity
TKWG_21245	COG2267	carboxylic ester hydrolase activity
TKWG_21265	COG3214	Protein conserved in bacteria
TKWG_21270	COG0583	DNA-binding transcription factor activity
TKWG_21275	COG1116	anion transmembrane transporter activity
TKWG_21275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TKWG_21280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKWG_21285	COG3839	Belongs to the ABC transporter superfamily
TKWG_21310	COG3971	2-oxopent-4-enoate hydratase activity
TKWG_21345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_21370	COG0477	Major facilitator Superfamily
TKWG_21375	COG0235	Class ii aldolase
TKWG_21380	COG0583	DNA-binding transcription factor activity
TKWG_21425	COG1764	response to oxidative stress
TKWG_21480	COG3210	domain, Protein
TKWG_21485	COG2831	hemolysin activation secretion protein
TKWG_21505	COG3501	Rhs element vgr protein
TKWG_21535	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_21540	COG0583	DNA-binding transcription factor activity
TKWG_21580	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_21610	COG0583	DNA-binding transcription factor activity
TKWG_21625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKWG_21630	COG0789	Transcriptional regulator
TKWG_21635	COG0778	Nitroreductase
TKWG_21645	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_21650	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_21715	COG0444	Belongs to the ABC transporter superfamily
TKWG_21720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKWG_21740	COG0583	DNA-binding transcription factor activity
TKWG_21760	COG0625	glutathione transferase activity
TKWG_21770	COG0604	alcohol dehydrogenase
TKWG_21790	COG1304	FMN binding
TKWG_21795	COG1304	FMN binding
TKWG_21830	COG1609	Transcriptional regulator
TKWG_21850	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_21855	COG2188	Transcriptional regulator
TKWG_21875	COG0066	3-isopropylmalate dehydratase activity
TKWG_21880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TKWG_21885	COG3501	Rhs element vgr protein
TKWG_21930	COG0745	RESPONSE REGULATOR receiver
TKWG_21935	COG4771	TonB-dependent receptor
TKWG_21945	COG0583	DNA-binding transcription factor activity
TKWG_21950	COG0667	Aldo Keto reductase
TKWG_21975	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_22065	COG0583	DNA-binding transcription factor activity
TKWG_22090	COG0066	3-isopropylmalate dehydratase activity
TKWG_22110	COG2271	Major facilitator Superfamily
TKWG_22130	COG1802	Transcriptional regulator
TKWG_22145	COG1309	transcriptional regulator
TKWG_22150	COG0655	NAD(P)H dehydrogenase (quinone) activity
TKWG_22160	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_22165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKWG_22180	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_22185	COG1024	Enoyl-CoA hydratase
TKWG_22200	COG1414	Transcriptional regulator
TKWG_22205	COG0604	alcohol dehydrogenase
TKWG_22245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_22260	COG1414	Transcriptional regulator
TKWG_22265	COG0159	tryptophan synthase activity
TKWG_22270	COG0133	tryptophan synthase activity
TKWG_22295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TKWG_22300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKWG_22300	COG2207	Transcriptional regulator
TKWG_22310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_22325	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_22330	COG1115	amino acid carrier protein
TKWG_22370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TKWG_22375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TKWG_22385	COG0693	protein deglycase activity
TKWG_22395	COG0438	transferase activity, transferring glycosyl groups
TKWG_22400	COG1525	nuclease
TKWG_22415	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_22420	COG1959	2 iron, 2 sulfur cluster binding
TKWG_22425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TKWG_22425	COG1017	nitric oxide dioxygenase activity
TKWG_22430	COG2860	membrane
TKWG_22435	COG1113	amino acid transport
TKWG_22440	COG0629	single-stranded DNA binding
TKWG_22450	COG1115	amino acid carrier protein
TKWG_22460	COG0748	coenzyme F420 binding
TKWG_22485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TKWG_22510	COG1414	Transcriptional regulator
TKWG_22525	COG0523	cobalamin synthesis protein
TKWG_22530	COG1228	amidohydrolase
TKWG_22575	COG1414	Transcriptional regulator
TKWG_22580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKWG_22585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKWG_22600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TKWG_22605	COG4521	taurine ABC transporter
TKWG_22610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_22620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_22670	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_22675	COG4948	Mandelate Racemase Muconate Lactonizing
TKWG_22680	COG2186	Transcriptional regulator
TKWG_22715	COG2186	Transcriptional regulator
TKWG_22720	COG0730	response to heat
TKWG_22740	COG1252	NADH dehydrogenase
TKWG_22765	COG0789	Transcriptional regulator
TKWG_22785	COG1607	acyl-coa hydrolase
TKWG_22790	COG2885	chlorophyll binding
TKWG_22830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKWG_22835	COG0492	ferredoxin-NADP+ reductase activity
TKWG_22850	COG0037	tRNA processing
TKWG_22855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TKWG_22855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TKWG_22865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TKWG_22870	COG2890	protein-(glutamine-N5) methyltransferase activity
TKWG_22875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TKWG_22905	COG1201	RNA secondary structure unwinding
TKWG_22955	COG3395	kinase activity
TKWG_22975	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_22980	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_22995	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_23015	COG4619	ABC transporter
TKWG_23070	COG1414	Transcriptional regulator
TKWG_23075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_23080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TKWG_23115	COG0534	Mate efflux family protein
TKWG_23120	COG0583	DNA-binding transcription factor activity
TKWG_23140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKWG_23155	COG0765	amino acid transport
TKWG_23190	COG2217	Heavy metal translocating P-type atpase
TKWG_23195	COG2301	Belongs to the HpcH HpaI aldolase family
TKWG_23205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_23225	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_23235	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_23240	COG1414	Transcriptional regulator
TKWG_23260	COG1250	3-hydroxyacyl-CoA dehydrogenase
TKWG_23260	COG1024	Enoyl-CoA hydratase
TKWG_23270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TKWG_23275	COG0318	PFAM AMP-dependent synthetase and ligase
TKWG_23280	COG2188	Transcriptional regulator
TKWG_23285	COG2721	sulfolactate sulfo-lyase activity
TKWG_23305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_23395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TKWG_23400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TKWG_23415	COG1596	polysaccharide export
TKWG_23440	COG2610	gluconate transmembrane transporter activity
TKWG_23460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TKWG_23485	COG1176	ABC-type spermidine putrescine transport system, permease component I
TKWG_23525	COG1566	PFAM secretion protein HlyD family protein
TKWG_23530	COG2814	Major facilitator Superfamily
TKWG_23585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_23615	COG0583	DNA-binding transcription factor activity
TKWG_23620	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_23625	COG0477	Major facilitator Superfamily
TKWG_23640	COG0436	Aminotransferase
TKWG_23645	COG0697	spore germination
TKWG_23650	COG0697	spore germination
TKWG_23655	COG2375	cellular response to nickel ion
TKWG_23660	COG1695	Transcriptional regulator
TKWG_23675	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_23710	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_23715	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_23720	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_23735	COG1960	acyl-CoA dehydrogenase activity
TKWG_23740	COG0045	succinate-CoA ligase (ADP-forming) activity
TKWG_23740	COG1042	CoA-binding domain protein
TKWG_23740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TKWG_23755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKWG_23760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TKWG_23785	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_23805	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_23820	COG1764	response to oxidative stress
TKWG_23830	COG0583	DNA-binding transcription factor activity
TKWG_23845	COG1595	DNA-templated transcription, initiation
TKWG_23865	COG2814	Major facilitator Superfamily
TKWG_23895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TKWG_23910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TKWG_23925	COG1965	Belongs to the frataxin family
TKWG_23950	COG1116	anion transmembrane transporter activity
TKWG_23960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKWG_23990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TKWG_24015	COG1088	dTDP-glucose 4,6-dehydratase activity
TKWG_24065	COG4232	protein-disulfide reductase activity
TKWG_24080	COG1324	tolerance protein
TKWG_24085	COG2814	Major facilitator Superfamily
TKWG_24095	COG0203	ribosomal protein L17
TKWG_24100	COG0202	RNA polymerase activity
TKWG_24105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TKWG_24110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TKWG_24115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TKWG_24120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TKWG_24130	COG0201	protein transport
TKWG_24135	COG0200	Binds to the 23S rRNA
TKWG_24140	COG1841	ribosomal large subunit assembly
TKWG_24145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TKWG_24150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TKWG_24165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TKWG_24170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TKWG_24175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TKWG_24180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TKWG_24185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TKWG_24195	COG3713	MltA-interacting MipA family protein
TKWG_24215	COG1176	ABC-type spermidine putrescine transport system, permease component I
TKWG_24230	COG3842	ATPase activity
TKWG_24235	COG3842	ATPase activity
TKWG_24240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TKWG_24325	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_24370	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKWG_24390	COG0411	ABC transporter
TKWG_24395	COG0640	Transcriptional regulator
TKWG_24400	COG3832	glyoxalase III activity
TKWG_24425	COG3622	Belongs to the hyi family
TKWG_24430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TKWG_24435	COG0800	Aldolase
TKWG_24440	COG0277	FAD linked oxidase domain protein
TKWG_24445	COG0129	dihydroxy-acid dehydratase activity
TKWG_24450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TKWG_24465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TKWG_24470	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_24525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TKWG_24530	COG0800	Aldolase
TKWG_24535	COG3734	2-keto-3-deoxy-galactonokinase
TKWG_24540	COG0277	FAD linked oxidase domain protein
TKWG_24545	COG0277	FAD linked oxidase domain protein
TKWG_24560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TKWG_24565	COG0255	Belongs to the universal ribosomal protein uL29 family
TKWG_24570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TKWG_24575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TKWG_24580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TKWG_24585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TKWG_24590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TKWG_24595	COG0089	rRNA binding
TKWG_24600	COG0088	Forms part of the polypeptide exit tunnel
TKWG_24605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TKWG_24615	COG2423	ornithine cyclodeaminase activity
TKWG_24655	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKWG_24680	COG2308	Evidence 4 Homologs of previously reported genes of
TKWG_24695	COG2308	Evidence 4 Homologs of previously reported genes of
TKWG_24700	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_24705	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_24710	COG1012	belongs to the aldehyde dehydrogenase family
TKWG_24735	COG1322	Protein conserved in bacteria
TKWG_24765	COG2011	ABC-type metal ion transport system permease component
TKWG_24775	COG0051	transcription antitermination factor activity, RNA binding
TKWG_24780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TKWG_24790	COG0049	tRNA binding
TKWG_24795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TKWG_24815	COG2205	protein histidine kinase activity
TKWG_24815	COG0784	Response regulator, receiver
TKWG_24820	COG2301	Belongs to the HpcH HpaI aldolase family
TKWG_24825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TKWG_24830	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TKWG_24850	COG1960	acyl-CoA dehydrogenase activity
TKWG_24860	COG1917	Cupin 2, conserved barrel domain protein
TKWG_24860	COG2169	Transcriptional regulator
TKWG_24880	COG3313	Fe-S protein
TKWG_24905	COG2818	Glycosylase
TKWG_24920	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_24925	COG1802	Transcriptional regulator
TKWG_24950	COG3246	L-lysine catabolic process to acetate
TKWG_24955	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_24985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TKWG_25000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TKWG_25025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TKWG_25070	COG1028	Short-chain dehydrogenase reductase Sdr
TKWG_25075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TKWG_25100	COG2423	ornithine cyclodeaminase activity
TKWG_25120	COG2133	pyrroloquinoline quinone binding
TKWG_25125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_25130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TKWG_25145	COG0222	ribosome binding
TKWG_25150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TKWG_25155	COG0081	regulation of translation
TKWG_25160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TKWG_25170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKWG_25185	COG1192	Involved in chromosome partitioning
TKWG_25190	COG0357	Ribosomal RNA small subunit methyltransferase G
TKWG_25195	COG0445	tRNA wobble uridine modification
TKWG_25200	COG0445	tRNA wobble uridine modification
TKWG_25205	COG0445	tRNA wobble uridine modification
TKWG_25210	COG0436	Aminotransferase
TKWG_25220	COG0537	adenosine 5'-monophosphoramidase activity
TKWG_25225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TKWG_25230	COG0477	Major facilitator Superfamily
TKWG_25235	COG3180	Ammonia monooxygenase
TKWG_25270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TKWG_25300	COG0842	Transport permease protein
TKWG_25305	COG0842	Transport permease protein
TKWG_25310	COG1131	(ABC) transporter
TKWG_25345	COG0583	DNA-binding transcription factor activity
TKWG_25365	COG0045	succinate-CoA ligase (ADP-forming) activity
TKWG_25365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TKWG_25365	COG1042	CoA-binding domain protein
TKWG_25370	COG1960	acyl-CoA dehydrogenase activity
TKWG_25390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKWG_25405	COG0706	membrane insertase activity
TKWG_25415	COG0594	ribonuclease P activity
TKWG_25420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TKWG_25544	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKWG_25554	COG3181	Tripartite tricarboxylate transporter family receptor
TKWG_25609	COG0629	single-stranded DNA binding
TKWG_25619	COG2948	multi-organism process
TKWG_25624	COG3504	Conjugal transfer protein
TKWG_25739	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TKWG_25779	COG4974	Belongs to the 'phage' integrase family
TKWG_25794	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TKWG_25799	COG0583	DNA-binding transcription factor activity
TKWG_25809	COG1272	protein, Hemolysin III
TKWG_25819	COG0583	DNA-binding transcription factor activity