locus-tag	class	description
Pan181_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan181_00040	COG0187	DNA topoisomerase II activity
Pan181_00090	COG4191	Histidine kinase
Pan181_00280	COG0165	Argininosuccinate lyase
Pan181_00300	COG2204	response regulator
Pan181_00350	COG0582	viral genome integration into host DNA
Pan181_00380	COG1252	NADH dehydrogenase
Pan181_00450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_00460	COG1309	transcriptional regulator
Pan181_00680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_00700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_00710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan181_00720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Pan181_00990	COG3119	arylsulfatase activity
Pan181_01000	COG0052	Belongs to the universal ribosomal protein uS2 family
Pan181_01010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Pan181_01020	COG0528	UMP kinase activity
Pan181_01030	COG0233	cytoplasmic translational termination
Pan181_01050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Pan181_01150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Pan181_01230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan181_01230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan181_01250	COG3119	arylsulfatase activity
Pan181_01260	COG4636	protein conserved in cyanobacteria
Pan181_01280	COG3258	Cytochrome c
Pan181_01300	COG0673	inositol 2-dehydrogenase activity
Pan181_01340	COG3250	beta-galactosidase activity
Pan181_01360	COG0459	protein refolding
Pan181_01370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan181_01460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Pan181_01470	COG0666	response to abiotic stimulus
Pan181_01530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Pan181_01540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Pan181_01580	COG4864	UPF0365 protein
Pan181_01680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Pan181_01690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Pan181_01750	COG0437	4 iron, 4 sulfur cluster binding
Pan181_01770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Pan181_01870	COG0604	alcohol dehydrogenase
Pan181_01870	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_01870	COG3321	synthase
Pan181_01880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan181_01920	COG0126	phosphoglycerate kinase activity
Pan181_01960	COG2815	serine threonine protein kinase
Pan181_01960	COG0515	serine threonine protein kinase
Pan181_01990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_02040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Pan181_02070	COG3361	conserved protein (COG2071)
Pan181_02090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Pan181_02100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Pan181_02110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan181_02130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Pan181_02150	COG0758	DNA mediated transformation
Pan181_02180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Pan181_02180	COG2755	lipolytic protein G-D-S-L family
Pan181_02190	COG1228	amidohydrolase
Pan181_02230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Pan181_02250	COG0259	pyridoxamine-phosphate oxidase activity
Pan181_02260	COG3119	arylsulfatase activity
Pan181_02270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_02300	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_02360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_02460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Pan181_02470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Pan181_02480	COG0588	phosphoglycerate mutase activity
Pan181_02490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Pan181_02670	COG0406	alpha-ribazole phosphatase activity
Pan181_02770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Pan181_02830	COG0069	glutamate synthase activity
Pan181_02890	COG4771	TonB-dependent receptor
Pan181_02960	COG2895	sulfate adenylyltransferase (ATP) activity
Pan181_02960	COG0529	Catalyzes the synthesis of activated sulfate
Pan181_02990	COG0175	sulfate reduction
Pan181_03030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Pan181_03040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_03170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Pan181_03180	COG1408	metallophosphoesterase
Pan181_03200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Pan181_03210	COG0488	(ABC) transporter
Pan181_03260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Pan181_03350	COG5016	pyruvate
Pan181_03350	COG0511	ligase activity, forming carbon-carbon bonds
Pan181_03420	COG0745	RESPONSE REGULATOR receiver
Pan181_03430	COG2204	response regulator
Pan181_03450	COG3437	response regulator, receiver
Pan181_03480	COG0745	RESPONSE REGULATOR receiver
Pan181_03490	COG2201	protein-glutamate methylesterase activity
Pan181_03560	COG2258	MOSC domain
Pan181_03570	COG0512	Glutamine amidotransferase of anthranilate synthase
Pan181_03580	COG2195	Cleaves the N-terminal amino acid of tripeptides
Pan181_03590	COG3119	arylsulfatase activity
Pan181_03630	COG2801	Transposase and inactivated derivatives
Pan181_03750	COG2719	SpoVR family
Pan181_03770	COG2718	Belongs to the UPF0229 family
Pan181_03790	COG2766	serine protein kinase
Pan181_03830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Pan181_03860	COG0539	negative regulation of cytoplasmic translation
Pan181_03870	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Pan181_03930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Pan181_03940	COG0799	negative regulation of ribosome biogenesis
Pan181_03950	COG0018	arginyl-trna synthetase
Pan181_03990	COG2223	nitrite transmembrane transporter activity
Pan181_04150	COG3264	Mechanosensitive ion channel
Pan181_04150	COG1511	domain protein
Pan181_04160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Pan181_04190	COG1530	ribonuclease E activity
Pan181_04230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Pan181_04230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Pan181_04230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Pan181_04270	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_04330	COG1216	Glycosyl transferase, family 2
Pan181_04350	COG2183	response to ionizing radiation
Pan181_04390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Pan181_04400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Pan181_04400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Pan181_04410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Pan181_04420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Pan181_04430	COG0793	Belongs to the peptidase S41A family
Pan181_04440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Pan181_04450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_04460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_04480	COG3842	ATPase activity
Pan181_04540	COG0616	signal peptide processing
Pan181_04610	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Pan181_04770	COG4172	Belongs to the ABC transporter superfamily
Pan181_04780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Pan181_04800	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
Pan181_04850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_05100	COG0297	glycogen (starch) synthase activity
Pan181_05110	COG1448	Aminotransferase
Pan181_05170	COG0848	biopolymer transport protein
Pan181_05200	COG0159	tryptophan synthase activity
Pan181_05230	COG3779	Protein conserved in bacteria
Pan181_05240	COG0133	tryptophan synthase activity
Pan181_05250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Pan181_05260	COG0784	Response regulator, receiver
Pan181_05270	COG4251	negative regulation of phosphorylation
Pan181_05330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Pan181_05510	COG2304	oxidoreductase activity
Pan181_05580	COG1595	DNA-templated transcription, initiation
Pan181_05630	COG3707	response regulator
Pan181_05640	COG3237	CsbD-like
Pan181_05660	COG5487	UPF0391 membrane protein
Pan181_05670	COG0515	serine threonine protein kinase
Pan181_05670	COG2815	serine threonine protein kinase
Pan181_05690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Pan181_05740	COG0529	Catalyzes the synthesis of activated sulfate
Pan181_05780	COG1131	(ABC) transporter
Pan181_05790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Pan181_05810	COG1663	tetraacyldisaccharide 4'-kinase activity
Pan181_05860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan181_05890	COG3293	Transposase
Pan181_05950	COG0163	prenyltransferase activity
Pan181_05960	COG2226	methyltransferase
Pan181_05970	COG2045	Belongs to the ComB family
Pan181_05980	COG0423	glycine-tRNA ligase activity
Pan181_06010	COG2133	pyrroloquinoline quinone binding
Pan181_06040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Pan181_06050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Pan181_06060	COG2205	protein histidine kinase activity
Pan181_06060	COG0784	Response regulator, receiver
Pan181_06070	COG0328	RNA-DNA hybrid ribonuclease activity
Pan181_06080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Pan181_06130	COG1691	(AIR) carboxylase
Pan181_06250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_06320	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_06390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Pan181_06400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Pan181_06440	COG1449	Belongs to the glycosyl hydrolase 57 family
Pan181_06460	COG0840	transmembrane signaling receptor activity
Pan181_06470	COG1234	tRNA 3'-trailer cleavage
Pan181_06510	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Pan181_06550	COG0515	serine threonine protein kinase
Pan181_06550	COG0457	Tetratricopeptide repeat
Pan181_06580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Pan181_06650	COG2096	Adenosyltransferase
Pan181_06700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_06710	COG1090	epimerase
Pan181_06780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_06810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Pan181_06830	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan181_06970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Pan181_07010	COG0438	transferase activity, transferring glycosyl groups
Pan181_07020	COG0438	transferase activity, transferring glycosyl groups
Pan181_07060	COG1131	(ABC) transporter
Pan181_07120	COG0714	Associated with various cellular activities
Pan181_07190	COG0347	Belongs to the P(II) protein family
Pan181_07200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Pan181_07230	COG0811	peptide transport
Pan181_07260	COG0242	peptide deformylase activity
Pan181_07270	COG3293	Transposase
Pan181_07290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Pan181_07310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_07320	COG3293	Transposase
Pan181_07360	COG0347	Belongs to the P(II) protein family
Pan181_07380	COG3119	arylsulfatase activity
Pan181_07410	COG1131	(ABC) transporter
Pan181_07450	COG0124	histidyl-tRNA synthetase
Pan181_07470	COG3293	Transposase
Pan181_07500	COG3119	arylsulfatase activity
Pan181_07540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Pan181_07540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Pan181_07570	COG0196	riboflavin kinase activity
Pan181_07600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Pan181_07630	COG1229	Formylmethanofuran dehydrogenase subunit A
Pan181_07680	COG0058	SHG alpha-glucan phosphorylase activity
Pan181_07700	COG1515	deoxyribonuclease V activity
Pan181_07710	COG0438	transferase activity, transferring glycosyl groups
Pan181_07760	COG1819	glycosyl
Pan181_07810	COG1595	DNA-templated transcription, initiation
Pan181_07850	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_07920	COG0095	Lipoate-protein ligase
Pan181_07940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan181_07950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan181_07960	COG0509	glycine decarboxylation via glycine cleavage system
Pan181_07970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Pan181_07980	COG0557	exoribonuclease II activity
Pan181_08000	COG3293	Transposase
Pan181_08010	COG1253	flavin adenine dinucleotide binding
Pan181_08020	COG3481	metal-dependent phosphohydrolase, HD sub domain
Pan181_08030	COG0442	prolyl-tRNA aminoacylation
Pan181_08040	COG1598	PFAM Uncharacterised protein family UPF0150
Pan181_08120	COG4372	Transposase
Pan181_08150	COG3119	arylsulfatase activity
Pan181_08170	COG0217	transcriptional regulatory protein
Pan181_08190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Pan181_08200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Pan181_08210	COG0195	Participates in both transcription termination and antitermination
Pan181_08230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_08340	COG2801	Transposase and inactivated derivatives
Pan181_08380	COG0445	tRNA wobble uridine modification
Pan181_08400	COG3240	lipase activity
Pan181_08420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_08430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_08440	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_08450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Pan181_08460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Pan181_08560	COG2255	four-way junction helicase activity
Pan181_08600	COG1073	alpha beta
Pan181_08610	COG1073	alpha beta
Pan181_08630	COG0632	four-way junction helicase activity
Pan181_08660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Pan181_08670	COG0215	cysteine-tRNA ligase activity
Pan181_08680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Pan181_08700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Pan181_08780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_08810	COG4284	Utp--glucose-1-phosphate uridylyltransferase
Pan181_08820	COG1994	Peptidase M50
Pan181_08850	COG0489	protein tyrosine kinase activity
Pan181_08910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan181_08940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_08950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Pan181_08980	COG0352	thiamine-phosphate diphosphorylase activity
Pan181_09000	COG0542	response to heat
Pan181_09020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Pan181_09030	COG1127	ABC transporter
Pan181_09080	COG3852	Histidine kinase
Pan181_09100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Pan181_09110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_09120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_09130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Pan181_09140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Pan181_09150	COG4651	solute:proton antiporter activity
Pan181_09150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Pan181_09170	COG4536	flavin adenine dinucleotide binding
Pan181_09260	COG1752	Esterase of the alpha-beta hydrolase superfamily
Pan181_09270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Pan181_09280	COG0573	inorganic phosphate transmembrane transporter activity
Pan181_09290	COG0581	inorganic phosphate transmembrane transporter activity
Pan181_09300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Pan181_09310	COG0704	Plays a role in the regulation of phosphate uptake
Pan181_09320	COG0745	RESPONSE REGULATOR receiver
Pan181_09370	COG1201	RNA secondary structure unwinding
Pan181_09490	COG0135	phosphoribosylanthranilate isomerase activity
Pan181_09560	COG1459	type II secretion system
Pan181_09570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_09580	COG1366	Belongs to the anti-sigma-factor antagonist family
Pan181_09590	COG5002	protein histidine kinase activity
Pan181_09610	COG4969	Belongs to the N-Me-Phe pilin family
Pan181_09620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Pan181_09640	COG0515	serine threonine protein kinase
Pan181_09640	COG2815	serine threonine protein kinase
Pan181_09660	COG2814	Major facilitator Superfamily
Pan181_09690	COG2204	response regulator
Pan181_09700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Pan181_09730	COG0514	ATP-dependent DNA helicase (RecQ)
Pan181_09770	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_09790	COG0800	Aldolase
Pan181_09800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Pan181_09850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_09860	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Pan181_09880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Pan181_09880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Pan181_09890	COG1070	Carbohydrate kinase
Pan181_09920	COG4806	L-rhamnose isomerase
Pan181_09930	COG4977	sequence-specific DNA binding
Pan181_09990	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Pan181_10080	COG0515	serine threonine protein kinase
Pan181_10260	COG3344	reverse transcriptase
Pan181_10270	COG2860	membrane
Pan181_10310	COG1704	LemA family
Pan181_10320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Pan181_10330	COG1509	lysine 2,3-aminomutase activity
Pan181_10340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Pan181_10370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Pan181_10410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Pan181_10470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Pan181_10500	COG2267	carboxylic ester hydrolase activity
Pan181_10530	COG1164	Oligoendopeptidase f
Pan181_10550	COG0534	Mate efflux family protein
Pan181_10680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Pan181_10700	COG3706	GGDEF domain
Pan181_10800	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Pan181_10950	COG0564	pseudouridine synthase activity
Pan181_10960	COG1970	mechanosensitive ion channel activity
Pan181_10970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Pan181_10990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Pan181_11000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Pan181_11060	COG2801	Transposase and inactivated derivatives
Pan181_11070	COG1741	Belongs to the pirin family
Pan181_11100	COG2373	Large extracellular alpha-helical protein
Pan181_11140	COG0284	orotidine-5'-phosphate decarboxylase activity
Pan181_11150	COG2153	protein acetylation
Pan181_11170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Pan181_11200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Pan181_11240	COG0129	dihydroxy-acid dehydratase activity
Pan181_11300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Pan181_11310	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Pan181_11320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Pan181_11330	COG1715	Restriction endonuclease
Pan181_11350	COG2081	HI0933 family
Pan181_11360	COG0571	ribonuclease III activity
Pan181_11370	COG1011	Hydrolase
Pan181_11380	COG0859	PFAM glycosyl transferase family 9
Pan181_11420	COG2738	Putative neutral zinc metallopeptidase
Pan181_11440	COG2104	thiamine diphosphate biosynthetic process
Pan181_11450	COG2022	thiamine diphosphate biosynthetic process
Pan181_11460	COG1199	ATP-dependent helicase activity
Pan181_11480	COG4912	Dna alkylation repair
Pan181_11490	COG0107	imidazoleglycerol-phosphate synthase activity
Pan181_11500	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_11560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_11640	COG3132	Protein of unknown function, DUF480
Pan181_11660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_11680	COG0443	Heat shock 70 kDa protein
Pan181_11710	COG1902	pentaerythritol trinitrate reductase activity
Pan181_11730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Pan181_11740	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan181_11760	COG0662	Cupin 2, conserved barrel domain protein
Pan181_11760	COG2207	Transcriptional regulator
Pan181_11770	COG1064	alcohol dehydrogenase
Pan181_11780	COG0667	Aldo Keto reductase
Pan181_11800	COG3250	beta-galactosidase activity
Pan181_12000	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Pan181_12100	COG0137	argininosuccinate synthase activity
Pan181_12230	COG0110	maltose O-acetyltransferase activity
Pan181_12270	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_12400	COG1045	serine acetyltransferase
Pan181_12420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_12500	COG0438	transferase activity, transferring glycosyl groups
Pan181_12680	COG3119	arylsulfatase activity
Pan181_12690	COG0673	inositol 2-dehydrogenase activity
Pan181_12780	COG0515	serine threonine protein kinase
Pan181_12780	COG2815	serine threonine protein kinase
Pan181_12820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_12840	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_12860	COG3848	Pyruvate phosphate dikinase
Pan181_12860	COG0574	Belongs to the PEP-utilizing enzyme family
Pan181_12910	COG2382	esterase
Pan181_12910	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_12910	COG3693	PFAM glycoside hydrolase, family 10
Pan181_12920	COG1063	alcohol dehydrogenase
Pan181_12930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_13040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Pan181_13070	COG4191	Histidine kinase
Pan181_13090	COG2204	response regulator
Pan181_13120	COG0589	response to stress
Pan181_13150	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_13170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Pan181_13210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_13220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Pan181_13260	COG2239	Acts as a magnesium transporter
Pan181_13280	COG2322	membrane
Pan181_13310	COG0109	protoheme IX farnesyltransferase activity
Pan181_13340	COG0113	porphobilinogen synthase activity
Pan181_13350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Pan181_13360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_13380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_13390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Pan181_13390	COG1796	DNA polymerase
Pan181_13450	COG2010	Cytochrome c
Pan181_13460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Pan181_13490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Pan181_13520	COG0658	competence protein
Pan181_13570	COG0514	ATP-dependent DNA helicase (RecQ)
Pan181_13690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_13690	COG5549	protein import
Pan181_13700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Pan181_13730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Pan181_13750	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Pan181_13780	COG1017	nitric oxide dioxygenase activity
Pan181_13780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Pan181_13880	COG0517	IMP dehydrogenase activity
Pan181_13880	COG0516	GMP reductase activity
Pan181_13930	COG0222	ribosome binding
Pan181_13960	COG0469	pyruvate kinase activity
Pan181_13980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Pan181_13990	COG3437	response regulator, receiver
Pan181_13990	COG2770	Histidine kinase
Pan181_14030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Pan181_14040	COG0142	geranyltranstransferase activity
Pan181_14050	COG1722	exodeoxyribonuclease VII activity
Pan181_14060	COG1570	exodeoxyribonuclease VII activity
Pan181_14080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Pan181_14150	COG0037	tRNA processing
Pan181_14170	COG1418	mRNA catabolic process
Pan181_14180	COG1692	metallophosphoesterase
Pan181_14290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Pan181_14390	COG0343	queuine tRNA-ribosyltransferase activity
Pan181_14410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Pan181_14410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Pan181_14440	COG0784	Response regulator, receiver
Pan181_14440	COG2198	Histidine kinase
Pan181_14440	COG2205	protein histidine kinase activity
Pan181_14470	COG0714	Associated with various cellular activities
Pan181_14490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_14520	COG3335	DDE superfamily endonuclease
Pan181_14560	COG4191	Histidine kinase
Pan181_14580	COG3119	arylsulfatase activity
Pan181_14670	COG3384	dioxygenase
Pan181_14710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Pan181_14720	COG4974	Belongs to the 'phage' integrase family
Pan181_14900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan181_14910	COG1684	flagellar biosynthetic protein fliR
Pan181_14930	COG1338	Plays a role in the flagellum-specific transport system
Pan181_15030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Pan181_15070	COG1157	protein secretion by the type III secretion system
Pan181_15110	COG1677	Flagellar hook-basal body complex protein FliE
Pan181_15120	COG1558	bacterial-type flagellum-dependent cell motility
Pan181_15130	COG1815	bacterial-type flagellum-dependent cell motility
Pan181_15150	COG3852	Histidine kinase
Pan181_15190	COG0039	L-malate dehydrogenase activity
Pan181_15200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan181_15210	COG1419	protein localization to endoplasmic reticulum
Pan181_15240	COG1191	sigma factor activity
Pan181_15250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Pan181_15260	COG1078	dGTPase activity
Pan181_15280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Pan181_15280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_15290	COG1404	Belongs to the peptidase S8 family
Pan181_15300	COG3958	Transketolase
Pan181_15310	COG3959	Transketolase, thiamine diphosphate binding domain
Pan181_15320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_15330	COG0438	transferase activity, transferring glycosyl groups
Pan181_15370	COG0667	Aldo Keto reductase
Pan181_15420	COG0489	protein tyrosine kinase activity
Pan181_15590	COG0235	Class ii aldolase
Pan181_15600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Pan181_15610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Pan181_15620	COG0556	nucleotide-excision repair
Pan181_15650	COG3977	Valine--pyruvate aminotransferase
Pan181_15680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_15730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Pan181_15740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Pan181_15750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_15790	COG3119	arylsulfatase activity
Pan181_15850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Pan181_15870	COG3119	arylsulfatase activity
Pan181_15900	COG3781	membrane
Pan181_15940	COG0519	Catalyzes the synthesis of GMP from XMP
Pan181_15940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Pan181_15950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Pan181_16000	COG0488	(ABC) transporter
Pan181_16060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Pan181_16090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Pan181_16130	COG2211	Major facilitator Superfamily
Pan181_16190	COG0295	cytidine deaminase activity
Pan181_16200	COG0275	rRNA processing
Pan181_16220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_16250	COG0646	methionine synthase
Pan181_16250	COG1410	methionine synthase
Pan181_16340	COG2165	general secretion pathway protein
Pan181_16390	COG1459	type II secretion system
Pan181_16400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_16480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Pan181_16500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan181_16550	COG1136	(ABC) transporter
Pan181_16570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Pan181_16620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_16670	COG4566	intracellular signal transduction
Pan181_16680	COG4566	intracellular signal transduction
Pan181_16690	COG4191	Histidine kinase
Pan181_16710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Pan181_16730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Pan181_16790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Pan181_16910	COG2197	response regulator
Pan181_16980	COG4537	Required for transformation and DNA binding
Pan181_16990	COG3401	FG-GAP repeat protein
Pan181_17000	COG3401	FG-GAP repeat protein
Pan181_17150	COG0840	transmembrane signaling receptor activity
Pan181_17160	COG1442	glycosyl transferase family 8
Pan181_17190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Pan181_17200	COG1185	polyribonucleotide nucleotidyltransferase activity
Pan181_17210	COG4191	Histidine kinase
Pan181_17240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Pan181_17250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Pan181_17340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Pan181_17370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Pan181_17380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_17410	COG0148	phosphopyruvate hydratase activity
Pan181_17450	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_17500	COG1674	ftsk spoiiie
Pan181_17510	COG0045	succinate-CoA ligase (ADP-forming) activity
Pan181_17520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Pan181_17620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Pan181_17630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Pan181_17690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_17720	COG0202	RNA polymerase activity
Pan181_17750	COG1560	Kdo2-lipid A biosynthetic process
Pan181_17770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Pan181_17780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Pan181_17800	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_17830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Pan181_17840	COG0802	atpase or kinase
Pan181_17920	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_17940	COG0363	glucosamine-6-phosphate deaminase activity
Pan181_17950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_17960	COG0673	inositol 2-dehydrogenase activity
Pan181_18000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Pan181_18030	COG0745	RESPONSE REGULATOR receiver
Pan181_18050	COG0745	RESPONSE REGULATOR receiver
Pan181_18130	COG1716	ATPase activity
Pan181_18140	COG3119	arylsulfatase activity
Pan181_18170	COG0793	Belongs to the peptidase S41A family
Pan181_18180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Pan181_18180	COG0321	lipoyl(octanoyl) transferase activity
Pan181_18190	COG0653	protein targeting
Pan181_18200	COG1519	Transferase
Pan181_18240	COG1131	(ABC) transporter
Pan181_18260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_18290	COG0473	3-isopropylmalate dehydrogenase activity
Pan181_18300	COG0515	serine threonine protein kinase
Pan181_18300	COG2815	serine threonine protein kinase
Pan181_18310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Pan181_18350	COG0590	tRNA wobble adenosine to inosine editing
Pan181_18400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Pan181_18410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Pan181_18420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Pan181_18450	COG3253	May function as heme-dependent peroxidase
Pan181_18510	COG3119	arylsulfatase activity
Pan181_18560	COG2801	Transposase and inactivated derivatives
Pan181_18650	COG0726	polysaccharide deacetylase
Pan181_18700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Pan181_18740	COG2843	Capsule synthesis protein
Pan181_18870	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Pan181_18950	COG3852	Histidine kinase
Pan181_19090	COG0714	Associated with various cellular activities
Pan181_19110	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Pan181_19130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Pan181_19270	COG0363	glucosamine-6-phosphate deaminase activity
Pan181_19310	COG3485	protocatechuate 3,4-dioxygenase
Pan181_19320	COG0778	Nitroreductase
Pan181_19330	COG1459	type II secretion system
Pan181_19370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_19390	COG2818	Glycosylase
Pan181_19400	COG0445	tRNA wobble uridine modification
Pan181_19470	COG2217	Heavy metal translocating P-type atpase
Pan181_19500	COG0348	domain, Protein
Pan181_19510	COG2010	Cytochrome c
Pan181_19530	COG3278	Belongs to the heme-copper respiratory oxidase family
Pan181_19570	COG2832	Protein of unknown function (DUF454)
Pan181_19580	COG2855	membrane
Pan181_19610	COG0738	Major facilitator superfamily
Pan181_19630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Pan181_19640	COG3118	belongs to the thioredoxin family
Pan181_19670	COG0471	metal ion transport
Pan181_19670	COG3273	potassium ion transport
Pan181_19920	COG0393	Putative heavy-metal-binding
Pan181_19950	COG0464	growth
Pan181_19960	COG2197	response regulator
Pan181_20010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_20030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_20040	COG0006	proline dipeptidase activity
Pan181_20060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Pan181_20070	COG0066	3-isopropylmalate dehydratase activity
Pan181_20110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Pan181_20190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Pan181_20240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Pan181_20300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_20310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Pan181_20350	COG3335	DDE superfamily endonuclease
Pan181_20390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Pan181_20440	COG0101	tRNA pseudouridine synthase activity
Pan181_20470	COG3335	DDE superfamily endonuclease
Pan181_20500	COG2815	serine threonine protein kinase
Pan181_20500	COG0515	serine threonine protein kinase
Pan181_20510	COG0825	malonyl-CoA metabolic process
Pan181_20680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Pan181_20750	COG0436	Aminotransferase
Pan181_20910	COG2755	lipolytic protein G-D-S-L family
Pan181_20920	COG2207	Transcriptional regulator
Pan181_20920	COG1609	Transcriptional regulator
Pan181_21060	COG2165	general secretion pathway protein
Pan181_21090	COG3250	beta-galactosidase activity
Pan181_21280	COG0515	serine threonine protein kinase
Pan181_21310	COG3481	metal-dependent phosphohydrolase, HD sub domain
Pan181_21330	COG2890	protein-(glutamine-N5) methyltransferase activity
Pan181_21340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Pan181_21350	COG0254	rRNA binding
Pan181_21410	COG2801	Transposase and inactivated derivatives
Pan181_21450	COG0443	Heat shock 70 kDa protein
Pan181_21470	COG2267	carboxylic ester hydrolase activity
Pan181_21540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Pan181_21560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_21600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Pan181_21610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Pan181_21620	COG0602	queuosine metabolic process
Pan181_21650	COG0151	Belongs to the GarS family
Pan181_21690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Pan181_21720	COG2226	methyltransferase
Pan181_21750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_21750	COG0167	dihydroorotate dehydrogenase activity
Pan181_21780	COG1505	serine-type exopeptidase activity
Pan181_21810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Pan181_21870	COG0848	biopolymer transport protein
Pan181_21880	COG0811	peptide transport
Pan181_21930	COG0745	RESPONSE REGULATOR receiver
Pan181_21940	COG3852	Histidine kinase
Pan181_22020	COG0166	Belongs to the GPI family
Pan181_22030	COG1045	serine acetyltransferase
Pan181_22050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Pan181_22070	COG1678	Uncharacterized ACR, COG1678
Pan181_22100	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Pan181_22110	COG2326	polyphosphate kinase activity
Pan181_22140	COG1940	carbohydrate kinase activity
Pan181_22150	COG3119	arylsulfatase activity
Pan181_22230	COG3119	arylsulfatase activity
Pan181_22240	COG3119	arylsulfatase activity
Pan181_22250	COG3250	beta-galactosidase activity
Pan181_22290	COG4409	exo-alpha-(2->6)-sialidase activity
Pan181_22370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_22380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_22420	COG3250	beta-galactosidase activity
Pan181_22490	COG2160	L-arabinose isomerase activity
Pan181_22510	COG1069	ribulokinase activity
Pan181_22570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_22580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_22590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_22670	COG0714	Associated with various cellular activities
Pan181_22700	COG0776	regulation of translation
Pan181_22770	COG5001	Diguanylate cyclase
Pan181_22780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_22840	COG1215	transferase activity, transferring glycosyl groups
Pan181_22870	COG1215	transferase activity, transferring glycosyl groups
Pan181_22880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_22910	COG1477	protein flavinylation
Pan181_22940	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Pan181_22950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Pan181_22960	COG1805	sodium ion transport
Pan181_23020	COG3119	arylsulfatase activity
Pan181_23040	COG3119	arylsulfatase activity
Pan181_23100	COG0515	serine threonine protein kinase
Pan181_23100	COG2815	serine threonine protein kinase
Pan181_23120	COG2207	Transcriptional regulator
Pan181_23160	COG1595	DNA-templated transcription, initiation
Pan181_23170	COG0515	serine threonine protein kinase
Pan181_23170	COG2815	serine threonine protein kinase
Pan181_23280	COG3119	arylsulfatase activity
Pan181_23350	COG3005	denitrification pathway
Pan181_23360	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Pan181_23370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_23760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Pan181_23820	COG1361	Conserved repeat domain
Pan181_24040	COG0811	peptide transport
Pan181_24050	COG0848	biopolymer transport protein
Pan181_24070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Pan181_24080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Pan181_24110	COG2207	Transcriptional regulator
Pan181_24110	COG1609	Transcriptional regulator
Pan181_24160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Pan181_24280	COG3119	arylsulfatase activity
Pan181_24360	COG4191	Histidine kinase
Pan181_24360	COG0784	Response regulator, receiver
Pan181_24400	COG3401	FG-GAP repeat protein
Pan181_24490	COG0473	3-isopropylmalate dehydrogenase activity
Pan181_24530	COG0268	Binds directly to 16S ribosomal RNA
Pan181_24550	COG1187	pseudouridine synthase activity
Pan181_24580	COG2936	dipeptidyl-peptidase activity
Pan181_24640	COG0805	protein transport
Pan181_24650	COG1482	cell wall glycoprotein biosynthetic process
Pan181_24670	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_24730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Pan181_24760	COG3706	GGDEF domain
Pan181_24900	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_24930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Pan181_25000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_25020	COG0471	metal ion transport
Pan181_25080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Pan181_25110	COG2340	Cysteine-rich secretory protein family
Pan181_25140	COG3537	Alpha-1,2-mannosidase
Pan181_25170	COG0038	chloride channel
Pan181_25180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Pan181_25190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan181_25290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Pan181_25310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Pan181_25330	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_25340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Pan181_25400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Pan181_25450	COG0131	Imidazoleglycerol-phosphate dehydratase
Pan181_25470	COG0205	6-phosphofructokinase activity
Pan181_25480	COG0439	Biotin carboxylase
Pan181_25490	COG0511	ligase activity, forming carbon-carbon bonds
Pan181_25500	COG0006	proline dipeptidase activity
Pan181_25560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Pan181_25570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Pan181_25580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Pan181_25590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Pan181_25630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Pan181_25640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_25670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Pan181_25740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_25740	COG3153	acetyltransferase
Pan181_25760	COG1606	tRNA processing
Pan181_25780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Pan181_25780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Pan181_25790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Pan181_25800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Pan181_25810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Pan181_25820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Pan181_25830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Pan181_25840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Pan181_25860	COG0356	it plays a direct role in the translocation of protons across the membrane
Pan181_25900	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Pan181_25940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_25960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Pan181_25970	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_26000	COG0004	ammonium transporteR
Pan181_26010	COG0552	protein localization to endoplasmic reticulum
Pan181_26020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Pan181_26040	COG2226	methyltransferase
Pan181_26120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Pan181_26130	COG0237	dephospho-CoA kinase activity
Pan181_26140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan181_26140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan181_26230	COG1082	Xylose isomerase domain protein TIM barrel
Pan181_26270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan181_26280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Pan181_26280	COG1333	cytochrome c biogenesis protein
Pan181_26330	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_26360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Pan181_26370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan181_26390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan181_26420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Pan181_26450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Pan181_26470	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_26520	COG0575	Belongs to the CDS family
Pan181_26540	COG0438	transferase activity, transferring glycosyl groups
Pan181_26550	COG2244	polysaccharide biosynthetic process
Pan181_26630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan181_26670	COG0653	protein targeting
Pan181_26720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Pan181_26750	COG1131	(ABC) transporter
Pan181_26780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan181_26790	COG4555	ABC transporter
Pan181_26810	COG0402	S-adenosylhomocysteine deaminase activity
Pan181_26850	COG0659	secondary active sulfate transmembrane transporter activity
Pan181_26900	COG0673	inositol 2-dehydrogenase activity
Pan181_26920	COG0424	maF-like protein
Pan181_26930	COG0564	pseudouridine synthase activity
Pan181_26940	COG0515	serine threonine protein kinase
Pan181_26940	COG2815	serine threonine protein kinase
Pan181_26950	COG4106	trans-aconitate 2-methyltransferase activity
Pan181_26960	COG0596	Alpha beta hydrolase
Pan181_26970	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_27000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan181_27010	COG1115	amino acid carrier protein
Pan181_27030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_27040	COG0396	ATPase activity
Pan181_27050	COG0719	Fe-S assembly protein
Pan181_27060	COG0719	Fe-S assembly protein
Pan181_27160	COG0848	biopolymer transport protein
Pan181_27200	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan181_27250	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_27310	COG2207	Transcriptional regulator
Pan181_27310	COG1609	Transcriptional regulator
Pan181_27320	COG0509	glycine decarboxylation via glycine cleavage system
Pan181_27330	COG0523	cobalamin synthesis protein
Pan181_27360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Pan181_27370	COG0142	geranyltranstransferase activity
Pan181_27400	COG1104	cysteine desulfurase activity
Pan181_27410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Pan181_27500	COG0714	Associated with various cellular activities
Pan181_27510	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Pan181_27520	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Pan181_27530	COG1335	isochorismatase
Pan181_27540	COG0494	nUDIX hydrolase
Pan181_27550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Pan181_27570	COG0657	acetylesterase activity
Pan181_27730	COG0784	Response regulator, receiver
Pan181_27730	COG4191	Histidine kinase
Pan181_27760	COG3852	Histidine kinase
Pan181_27870	COG2204	response regulator
Pan181_27880	COG3852	Histidine kinase
Pan181_27910	COG1538	Outer membrane efflux protein
Pan181_27930	COG3119	arylsulfatase activity
Pan181_27990	COG3293	Transposase
Pan181_28060	COG4650	regulator
Pan181_28090	COG0430	RNA-3'-phosphate cyclase activity
Pan181_28180	COG1942	4-Oxalocrotonate Tautomerase
Pan181_28250	COG1064	alcohol dehydrogenase
Pan181_28260	COG4221	oxidoreductase activity
Pan181_28270	COG2207	Transcriptional regulator
Pan181_28300	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_28400	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_28420	COG1802	Transcriptional regulator
Pan181_28520	COG4941	Belongs to the sigma-70 factor family
Pan181_28630	COG3458	cephalosporin-C deacetylase activity
Pan181_28640	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_28730	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_28820	COG3119	arylsulfatase activity
Pan181_29370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Pan181_29380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Pan181_29390	COG1205	dead DEAH box helicase
Pan181_29390	COG1111	helicase
Pan181_29470	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Pan181_29490	COG2801	Transposase and inactivated derivatives
Pan181_29620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Pan181_29630	COG0583	DNA-binding transcription factor activity
Pan181_29640	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Pan181_29660	COG0123	including yeast histone deacetylase and acetoin utilization protein
Pan181_29710	COG4122	O-methyltransferase activity
Pan181_29720	COG2124	cytochrome p450
Pan181_29760	COG1397	ADP-ribosylglycohydrolase
Pan181_29800	COG0701	Predicted permease
Pan181_29820	COG2115	Belongs to the xylose isomerase family
Pan181_29890	COG1349	DNA-binding transcription factor activity
Pan181_29900	COG4869	propanediol catabolic process
Pan181_29910	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Pan181_29930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Pan181_29990	COG0235	Class ii aldolase
Pan181_30000	COG0039	L-malate dehydrogenase activity
Pan181_30070	COG0105	UTP biosynthetic process
Pan181_30080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Pan181_30090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_30110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan181_30120	COG1321	iron dependent repressor
Pan181_30120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan181_30130	COG1121	(ABC) transporter
Pan181_30140	COG0803	Belongs to the bacterial solute-binding protein 9 family
Pan181_30160	COG0612	Peptidase, M16
Pan181_30200	COG2217	Heavy metal translocating P-type atpase
Pan181_30220	COG0673	inositol 2-dehydrogenase activity
Pan181_30250	COG4977	sequence-specific DNA binding
Pan181_30260	COG0543	2 iron, 2 sulfur cluster binding
Pan181_30270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Pan181_30270	COG0493	'glutamate synthase
Pan181_30280	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_30320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_30320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan181_30320	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan181_30320	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan181_30350	COG3243	poly(R)-hydroxyalkanoic acid synthase
Pan181_30360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Pan181_30370	COG4770	biotin carboxylase activity
Pan181_30390	COG2755	lipolytic protein G-D-S-L family
Pan181_30410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Pan181_30420	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Pan181_30430	COG4770	biotin carboxylase activity
Pan181_30460	COG1703	isobutyryl-CoA mutase activity
Pan181_30500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Pan181_30510	COG3243	poly(R)-hydroxyalkanoic acid synthase
Pan181_30540	COG0183	Belongs to the thiolase family
Pan181_30570	COG3119	arylsulfatase activity
Pan181_30700	COG3119	arylsulfatase activity
Pan181_30710	COG3119	arylsulfatase activity
Pan181_30730	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_30780	COG3119	arylsulfatase activity
Pan181_30790	COG2814	Major facilitator Superfamily
Pan181_30830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_30860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_30880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_30890	COG0673	inositol 2-dehydrogenase activity
Pan181_30900	COG1250	3-hydroxyacyl-CoA dehydrogenase
Pan181_30920	COG1609	Transcriptional regulator
Pan181_30990	COG2188	Transcriptional regulator
Pan181_31000	COG5285	phytanoyl-CoA dioxygenase
Pan181_31040	COG0006	proline dipeptidase activity
Pan181_31170	COG0438	transferase activity, transferring glycosyl groups
Pan181_31190	COG2204	response regulator
Pan181_31220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Pan181_31230	COG1091	dTDP-4-dehydrorhamnose reductase activity
Pan181_31250	COG3119	arylsulfatase activity
Pan181_31260	COG2706	6-phosphogluconolactonase activity
Pan181_31320	COG2204	response regulator
Pan181_31330	COG2814	Major facilitator Superfamily
Pan181_31370	COG1846	Transcriptional regulator
Pan181_31410	COG2304	oxidoreductase activity
Pan181_31440	COG0714	Associated with various cellular activities
Pan181_31480	COG3119	arylsulfatase activity
Pan181_31480	COG3408	Glycogen debranching enzyme
Pan181_31510	COG2165	general secretion pathway protein
Pan181_31570	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_31610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_31620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Pan181_31760	COG2814	Major facilitator Superfamily
Pan181_31810	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_31820	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_31830	COG0738	Major facilitator superfamily
Pan181_31840	COG3618	amidohydrolase
Pan181_31850	COG1063	alcohol dehydrogenase
Pan181_31900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_31900	COG0515	serine threonine protein kinase
Pan181_31910	COG2115	Belongs to the xylose isomerase family
Pan181_31930	COG2169	Transcriptional regulator
Pan181_31990	COG2207	Transcriptional regulator
Pan181_31990	COG1609	Transcriptional regulator
Pan181_32020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_32030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_32090	COG3119	arylsulfatase activity
Pan181_32340	COG1518	maintenance of DNA repeat elements
Pan181_32350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Pan181_32490	COG0515	serine threonine protein kinase
Pan181_32490	COG2815	serine threonine protein kinase
Pan181_32550	COG1396	sequence-specific DNA binding
Pan181_32560	COG2207	Transcriptional regulator
Pan181_32560	COG1609	Transcriptional regulator
Pan181_32570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_32580	COG0247	lactate metabolic process
Pan181_32580	COG2181	nitrate reductase activity
Pan181_32600	COG2086	electron transfer activity
Pan181_32680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_32690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Pan181_32710	COG1872	DUF167
Pan181_32800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Pan181_32830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_32860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_32880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Pan181_32920	COG0626	cystathionine gamma-synthase activity
Pan181_32930	COG0180	Tryptophanyl-tRNA synthetase
Pan181_32940	COG0167	dihydroorotate dehydrogenase activity
Pan181_32970	COG0727	PFAM Uncharacterised protein family (UPF0153)
Pan181_32990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Pan181_33000	COG0314	molybdopterin synthase activity
Pan181_33100	COG0247	lactate metabolic process
Pan181_33100	COG0277	FAD linked oxidase domain protein
Pan181_33110	COG0302	gtp cyclohydrolase
Pan181_33140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Pan181_33240	COG0788	formyltetrahydrofolate deformylase activity
Pan181_33280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Pan181_33280	COG0617	tRNA 3'-terminal CCA addition
Pan181_33280	COG0517	IMP dehydrogenase activity
Pan181_33310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_33330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_33340	COG1459	type II secretion system
Pan181_33430	COG1450	Type ii and iii secretion system protein
Pan181_33460	COG1131	(ABC) transporter
Pan181_33530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Pan181_33590	COG3119	arylsulfatase activity
Pan181_33680	COG3293	Transposase
Pan181_33730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Pan181_33740	COG0515	serine threonine protein kinase
Pan181_33740	COG2815	serine threonine protein kinase
Pan181_33750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Pan181_33780	COG0693	protein deglycase activity
Pan181_33790	COG0824	Thioesterase
Pan181_33820	COG1078	dGTPase activity
Pan181_33880	COG4191	Histidine kinase
Pan181_33940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Pan181_33950	COG3021	interspecies interaction between organisms
Pan181_33980	COG0116	Belongs to the methyltransferase superfamily
Pan181_33980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Pan181_34000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Pan181_34000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_34010	COG1546	Belongs to the CinA family
Pan181_34010	COG1058	Belongs to the CinA family
Pan181_34020	COG1233	COG1233 Phytoene dehydrogenase and related
Pan181_34030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_34040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_34050	COG1070	Carbohydrate kinase
Pan181_34160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Pan181_34200	COG2207	Transcriptional regulator
Pan181_34200	COG1609	Transcriptional regulator
Pan181_34240	COG1609	Transcriptional regulator
Pan181_34240	COG2207	Transcriptional regulator
Pan181_34260	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_34270	COG5505	Protein of unknown function (DUF819)
Pan181_34290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Pan181_34400	COG0445	tRNA wobble uridine modification
Pan181_34420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_34490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Pan181_34510	COG3335	DDE superfamily endonuclease
Pan181_34670	COG1321	iron dependent repressor
Pan181_34710	COG0463	Glycosyl transferase, family 2
Pan181_34780	COG0673	inositol 2-dehydrogenase activity
Pan181_34790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_34820	COG2234	aminopeptidase activity
Pan181_34830	COG0784	Response regulator, receiver
Pan181_34840	COG3852	Histidine kinase
Pan181_34850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Pan181_34890	COG4717	serine-type aminopeptidase activity
Pan181_34900	COG0564	pseudouridine synthase activity
Pan181_34910	COG0300	oxidoreductase activity
Pan181_34920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Pan181_34980	COG0515	serine threonine protein kinase
Pan181_34980	COG2815	serine threonine protein kinase
Pan181_35010	COG0673	inositol 2-dehydrogenase activity
Pan181_35020	COG0745	RESPONSE REGULATOR receiver
Pan181_35030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Pan181_35050	COG2308	Evidence 4 Homologs of previously reported genes of
Pan181_35080	COG2307	Protein conserved in bacteria
Pan181_35080	COG2308	Evidence 4 Homologs of previously reported genes of
Pan181_35100	COG1115	amino acid carrier protein
Pan181_35140	COG0606	chelatase, subunit chli
Pan181_35180	COG2095	MarC family integral membrane protein
Pan181_35220	COG1858	cytochrome C peroxidase
Pan181_35250	COG2272	Belongs to the type-B carboxylesterase lipase family
Pan181_35280	COG4112	unkown
Pan181_35350	COG0275	rRNA processing
Pan181_35370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Pan181_35380	COG0784	Response regulator, receiver
Pan181_35390	COG4251	negative regulation of phosphorylation
Pan181_35400	COG0745	RESPONSE REGULATOR receiver
Pan181_35410	COG0745	RESPONSE REGULATOR receiver
Pan181_35420	COG2205	protein histidine kinase activity
Pan181_35430	COG0745	RESPONSE REGULATOR receiver
Pan181_35450	COG0316	Belongs to the HesB IscA family
Pan181_35470	COG1104	cysteine desulfurase activity
Pan181_35480	COG3119	arylsulfatase activity
Pan181_35570	COG0538	isocitrate dehydrogenase activity
Pan181_35670	COG3119	arylsulfatase activity
Pan181_35770	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_35790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_35800	COG3142	Participates in the control of copper homeostasis
Pan181_36120	COG3541	Predicted nucleotidyltransferase
Pan181_36170	COG1242	4 iron, 4 sulfur cluster binding
Pan181_36190	COG1162	GTPase activity
Pan181_36280	COG1090	epimerase
Pan181_36330	COG4464	protein tyrosine phosphatase activity
Pan181_36350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Pan181_36360	COG0357	Ribosomal RNA small subunit methyltransferase G
Pan181_36390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_36400	COG0315	cyclic pyranopterin monophosphate synthase activity
Pan181_36410	COG0142	geranyltranstransferase activity
Pan181_36430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Pan181_36440	COG0140	phosphoribosyl-ATP diphosphatase activity
Pan181_36460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Pan181_36490	COG0426	domain, Protein
Pan181_36490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Pan181_36500	COG0579	oxidoreductase
Pan181_36560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Pan181_36600	COG1706	bacterial-type flagellum-dependent cell motility
Pan181_36610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Pan181_36630	COG4786	Flagellar basal body rod
Pan181_36640	COG4786	Flagellar basal body rod
Pan181_36650	COG0617	tRNA 3'-terminal CCA addition
Pan181_36680	COG2095	MarC family integral membrane protein
Pan181_36730	COG0569	domain protein
Pan181_36760	COG1131	(ABC) transporter
Pan181_36770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Pan181_36780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Pan181_36790	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Pan181_36800	COG0667	Aldo Keto reductase
Pan181_36810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Pan181_36840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_36860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_36870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_36880	COG0649	NAD binding
Pan181_36890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Pan181_36900	COG0839	Belongs to the complex I subunit 6 family
Pan181_36910	COG0713	ATP synthesis coupled electron transport
Pan181_36920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Pan181_36940	COG1007	ATP synthesis coupled electron transport
Pan181_36980	COG0084	hydrolase, TatD family'
Pan181_37030	COG3408	Glycogen debranching enzyme
Pan181_37050	COG3119	arylsulfatase activity
Pan181_37060	COG1063	alcohol dehydrogenase
Pan181_37130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Pan181_37140	COG0798	PFAM Bile acid sodium symporter
Pan181_37160	COG0640	Transcriptional regulator
Pan181_37170	COG0701	Predicted permease
Pan181_37360	COG0542	response to heat
Pan181_37560	COG3335	DDE superfamily endonuclease
Pan181_37630	COG2801	Transposase and inactivated derivatives
Pan181_37850	COG0405	Gamma-glutamyltransferase
Pan181_37860	COG3876	Protein conserved in bacteria
Pan181_37880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Pan181_37890	COG2971	BadF BadG BcrA BcrD
Pan181_37900	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Pan181_37910	COG2207	Transcriptional regulator
Pan181_37910	COG1609	Transcriptional regulator
Pan181_37930	COG1649	PFAM Uncharacterised BCR, COG1649
Pan181_37940	COG2814	Major facilitator Superfamily
Pan181_37960	COG1472	Belongs to the glycosyl hydrolase 3 family
Pan181_37980	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_38020	COG2715	membrane protein required for spore maturation
Pan181_38030	COG0700	Nucleoside recognition
Pan181_38040	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan181_38050	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan181_38080	COG0745	RESPONSE REGULATOR receiver
Pan181_38090	COG3293	Transposase
Pan181_38400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Pan181_38410	COG0175	sulfate reduction
Pan181_38420	COG1959	2 iron, 2 sulfur cluster binding
Pan181_38450	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Pan181_38500	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Pan181_38660	COG0793	Belongs to the peptidase S41A family
Pan181_38740	COG3119	arylsulfatase activity
Pan181_38820	COG0835	chemotaxis
Pan181_38860	COG1053	succinate dehydrogenase
Pan181_38870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Pan181_38890	COG1196	nuclear chromosome segregation
Pan181_38910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Pan181_38920	COG0594	ribonuclease P activity
Pan181_38950	COG0515	serine threonine protein kinase
Pan181_38980	COG0470	DNA polymerase III
Pan181_38990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Pan181_39020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Pan181_39110	COG1136	(ABC) transporter
Pan181_39120	COG0577	efflux transmembrane transporter activity
Pan181_39120	COG1136	(ABC) transporter
Pan181_39130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Pan181_39140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Pan181_39140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Pan181_39180	COG0673	inositol 2-dehydrogenase activity
Pan181_39280	COG0714	Associated with various cellular activities
Pan181_39320	COG0009	L-threonylcarbamoyladenylate synthase
Pan181_39330	COG0698	ribose 5-phosphate isomerase
Pan181_39340	COG2379	hydroxypyruvate reductase
Pan181_39450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Pan181_39470	COG4591	ABC-type transport system involved in lipoprotein release permease component
Pan181_39480	COG1136	(ABC) transporter
Pan181_39560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Pan181_39570	COG4589	Belongs to the CDS family
Pan181_39580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Pan181_39590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Pan181_39600	COG0616	signal peptide processing
Pan181_39630	COG1040	competence protein
Pan181_39650	COG0181	hydroxymethylbilane synthase activity
Pan181_39660	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_39690	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_39720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Pan181_39780	COG2183	response to ionizing radiation
Pan181_39780	COG0539	negative regulation of cytoplasmic translation
Pan181_39830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Pan181_39840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Pan181_39850	COG0569	domain protein
Pan181_39860	COG0305	Participates in initiation and elongation during chromosome replication
Pan181_39870	COG0359	binds to the 23S rRNA
Pan181_39880	COG0629	single-stranded DNA binding
Pan181_39890	COG0360	Binds together with S18 to 16S ribosomal RNA
Pan181_39900	COG0193	aminoacyl-tRNA hydrolase activity
Pan181_39910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Pan181_39920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Pan181_39930	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_39960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Pan181_40030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Pan181_40050	COG0287	Prephenate dehydrogenase
Pan181_40060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Pan181_40070	COG0047	phosphoribosylformylglycinamidine synthase activity
Pan181_40090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_40100	COG0706	membrane insertase activity
Pan181_40100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_40120	COG1214	PFAM Peptidase M22, glycoprotease
Pan181_40160	COG1917	Cupin 2, conserved barrel domain protein
Pan181_40160	COG2207	Transcriptional regulator
Pan181_40260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Pan181_40270	COG1024	Enoyl-CoA hydratase
Pan181_40330	COG1217	gtp-binding protein TYPA
Pan181_40340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan181_40360	COG0484	heat shock protein binding
Pan181_40430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Pan181_40450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_40470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Pan181_40500	COG0495	leucyl-tRNA aminoacylation
Pan181_40530	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Pan181_40550	COG0516	GMP reductase activity
Pan181_40550	COG0517	IMP dehydrogenase activity
Pan181_40600	COG1032	radical SAM domain protein
Pan181_40610	COG0527	aspartate kinase activity
Pan181_40710	COG2204	response regulator
Pan181_40720	COG0205	6-phosphofructokinase activity
Pan181_40730	COG0667	Aldo Keto reductase
Pan181_40740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Pan181_40780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Pan181_40790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Pan181_40800	COG1758	RNA polymerase activity
Pan181_40810	COG0194	GDP metabolic process
Pan181_40820	COG1561	YicC-like family, N-terminal region
Pan181_40840	COG0149	triose-phosphate isomerase activity
Pan181_40850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Pan181_40870	COG0443	Heat shock 70 kDa protein
Pan181_40900	COG0542	response to heat
Pan181_40940	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_40970	COG1556	Lactate utilization protein
Pan181_40980	COG1139	Iron-sulfur cluster binding protein
Pan181_40990	COG0247	lactate metabolic process
Pan181_41020	COG0493	'glutamate synthase
Pan181_41030	COG0067	glutamate synthase
Pan181_41030	COG0069	glutamate synthase activity
Pan181_41030	COG0070	glutamate synthase
Pan181_41040	COG0583	DNA-binding transcription factor activity
Pan181_41050	COG3250	beta-galactosidase activity
Pan181_41060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Pan181_41140	COG1477	protein flavinylation
Pan181_41150	COG0673	inositol 2-dehydrogenase activity
Pan181_41160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Pan181_41210	COG0348	domain, Protein
Pan181_41230	COG1034	ATP synthesis coupled electron transport
Pan181_41260	COG1032	radical SAM domain protein
Pan181_41280	COG0525	valine-tRNA ligase activity
Pan181_41310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_41340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Pan181_41350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Pan181_41360	COG1216	Glycosyl transferase, family 2
Pan181_41370	COG0523	cobalamin synthesis protein
Pan181_41650	COG3437	response regulator, receiver
Pan181_41650	COG2770	Histidine kinase
Pan181_41690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Pan181_41710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Pan181_41730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Pan181_41770	COG0179	Fumarylacetoacetate (FAA) hydrolase
Pan181_41810	COG0736	holo-[acyl-carrier-protein] synthase activity
Pan181_41820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Pan181_41820	COG1754	DNA topoisomerase type I activity
Pan181_41860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_41870	COG0328	RNA-DNA hybrid ribonuclease activity
Pan181_41900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Pan181_41960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_41970	COG0488	(ABC) transporter
Pan181_42000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Pan181_42010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_42040	COG1968	undecaprenyl-diphosphatase activity
Pan181_42050	COG1793	dna ligase
Pan181_42050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Pan181_42110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Pan181_42170	COG0204	Acyl-transferase
Pan181_42170	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_42180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Pan181_42220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Pan181_42240	COG0288	reversible hydration of carbon dioxide
Pan181_42250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Pan181_42340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_42360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Pan181_42370	COG2201	protein-glutamate methylesterase activity
Pan181_42390	COG0835	chemotaxis
Pan181_42400	COG0643	Histidine kinase
Pan181_42400	COG0784	Response regulator, receiver
Pan181_42400	COG2198	Histidine kinase
Pan181_42410	COG0745	RESPONSE REGULATOR receiver
Pan181_42430	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_42440	COG0702	epimerase
Pan181_42450	COG3046	protein related to deoxyribodipyrimidine photolyase
Pan181_42550	COG0443	Heat shock 70 kDa protein
Pan181_42570	COG0443	Heat shock 70 kDa protein
Pan181_42640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Pan181_42660	COG1074	ATP-dependent DNA helicase activity
Pan181_42690	COG2197	response regulator
Pan181_42800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Pan181_42810	COG0484	heat shock protein binding
Pan181_42820	COG0459	protein refolding
Pan181_42830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan181_42840	COG0459	protein refolding
Pan181_42890	COG2165	general secretion pathway protein
Pan181_42910	COG0138	bifunctional purine biosynthesis protein purh
Pan181_42970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Pan181_42980	COG0386	Belongs to the glutathione peroxidase family
Pan181_43000	COG0228	four-way junction DNA binding
Pan181_43010	COG0336	Belongs to the RNA methyltransferase TrmD family
Pan181_43020	COG0335	large ribosomal subunit rRNA binding
Pan181_43040	COG0792	nuclease activity
Pan181_43070	COG0504	CTP synthase activity
Pan181_43120	COG1487	ribonuclease activity
Pan181_43150	COG0322	excinuclease ABC activity
Pan181_43190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan181_43220	COG1595	DNA-templated transcription, initiation
Pan181_43250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan181_43260	COG0742	ribosomal rna small subunit methyltransferase
Pan181_43270	COG2755	lipolytic protein G-D-S-L family
Pan181_43270	COG0657	acetylesterase activity
Pan181_43280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_43300	COG0604	alcohol dehydrogenase
Pan181_43310	COG2154	pterin-4-alpha-carbinolamine dehydratase
Pan181_43320	COG2197	response regulator
Pan181_43330	COG1902	pentaerythritol trinitrate reductase activity
Pan181_43390	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_43400	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Pan181_43400	COG1918	ferrous iron import across plasma membrane
Pan181_43420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_43450	COG5492	domain, Protein
Pan181_43450	COG4932	domain protein
Pan181_43480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Pan181_43490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Pan181_43500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Pan181_43520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Pan181_43530	COG0071	Belongs to the small heat shock protein (HSP20) family
Pan181_43610	COG0427	acetyl-CoA hydrolase
Pan181_43640	COG0481	GTPase activity
Pan181_43660	COG1324	tolerance protein
Pan181_43670	COG0438	transferase activity, transferring glycosyl groups
Pan181_43710	COG0205	6-phosphofructokinase activity
Pan181_43740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Pan181_43760	COG2095	MarC family integral membrane protein
Pan181_43770	COG0513	Belongs to the DEAD box helicase family
Pan181_43800	COG0724	RNA recognition motif
Pan181_43820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_43850	COG0596	Alpha beta hydrolase
Pan181_43900	COG0039	L-malate dehydrogenase activity
Pan181_43950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Pan181_43990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Pan181_44000	COG0081	regulation of translation
Pan181_44010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Pan181_44020	COG0222	ribosome binding
Pan181_44040	COG0085	RNA polymerase activity
Pan181_44050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Pan181_44060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Pan181_44070	COG0049	tRNA binding
Pan181_44080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_44310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Pan181_44320	COG0730	response to heat
Pan181_44380	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Pan181_44390	COG0189	ligase activity
Pan181_44420	COG2268	Band 7 protein
Pan181_44440	COG0673	inositol 2-dehydrogenase activity
Pan181_44450	COG0673	inositol 2-dehydrogenase activity
Pan181_44480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Pan181_44490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Pan181_44540	COG0191	fructose-bisphosphate aldolase activity
Pan181_44630	COG0051	transcription antitermination factor activity, RNA binding
Pan181_44640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Pan181_44650	COG0088	Forms part of the polypeptide exit tunnel
Pan181_44660	COG0089	rRNA binding
Pan181_44670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Pan181_44680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Pan181_44690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Pan181_44700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Pan181_44710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Pan181_44720	COG0255	Belongs to the universal ribosomal protein uL29 family
Pan181_44730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Pan181_44740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Pan181_44750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Pan181_44760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Pan181_44770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Pan181_44780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Pan181_44790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Pan181_44800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Pan181_44810	COG0200	Binds to the 23S rRNA
Pan181_44820	COG0201	protein transport
Pan181_44910	COG0386	Belongs to the glutathione peroxidase family
Pan181_44930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_44950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_44960	COG1459	type II secretion system
Pan181_45030	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_45060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_45070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Pan181_45100	COG4771	TonB-dependent receptor
Pan181_45120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_45190	COG0471	metal ion transport
Pan181_45190	COG3273	potassium ion transport
Pan181_45210	COG1192	Involved in chromosome partitioning
Pan181_45280	COG3293	Transposase
Pan181_45340	COG0673	inositol 2-dehydrogenase activity
Pan181_45390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Pan181_45400	COG0135	phosphoribosylanthranilate isomerase activity
Pan181_45410	COG3267	Type II secretory pathway component ExeA
Pan181_45410	COG3409	Peptidoglycan-binding domain 1 protein
Pan181_45430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Pan181_45440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Pan181_45470	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_45480	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Pan181_45490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Pan181_45540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_45740	COG3250	beta-galactosidase activity
Pan181_45750	COG1621	beta-fructofuranosidase activity
Pan181_45870	COG0811	peptide transport
Pan181_46220	COG3119	arylsulfatase activity
Pan181_46240	COG0203	ribosomal protein L17
Pan181_46250	COG0202	RNA polymerase activity
Pan181_46260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Pan181_46270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Pan181_46280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Pan181_46290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Pan181_46310	COG0590	tRNA wobble adenosine to inosine editing
Pan181_46330	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Pan181_46350	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_46440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Pan181_46450	COG0450	alkyl hydroperoxide reductase
Pan181_46490	COG1205	dead DEAH box helicase
Pan181_46490	COG1111	helicase
Pan181_46520	COG3359	exonuclease
Pan181_46580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Pan181_46610	COG0443	Heat shock 70 kDa protein
Pan181_46640	COG0740	serine-type endopeptidase activity
Pan181_46650	COG0740	serine-type endopeptidase activity
Pan181_46660	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan181_46730	COG1215	transferase activity, transferring glycosyl groups
Pan181_46740	COG0366	Alpha amylase catalytic
Pan181_46750	COG0438	transferase activity, transferring glycosyl groups
Pan181_46770	COG0438	transferase activity, transferring glycosyl groups
Pan181_46800	COG1131	(ABC) transporter
Pan181_46830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Pan181_46860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_46900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Pan181_46910	COG4166	transmembrane transport
Pan181_46920	COG0601	transmembrane transport
Pan181_46960	COG1774	PSP1 C-terminal conserved region
Pan181_46970	COG0537	adenosine 5'-monophosphoramidase activity
Pan181_47100	COG0840	transmembrane signaling receptor activity
Pan181_47120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Pan181_47150	COG1216	Glycosyl transferase, family 2
Pan181_47180	COG2244	polysaccharide biosynthetic process
Pan181_47200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Pan181_47210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_47220	COG2815	serine threonine protein kinase
Pan181_47220	COG0515	serine threonine protein kinase
Pan181_47230	COG0134	indole-3-glycerol-phosphate synthase activity
Pan181_47240	COG0668	transmembrane transport
Pan181_47330	COG1054	Belongs to the UPF0176 family
Pan181_47340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Pan181_47370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Pan181_47390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_47400	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Pan181_47410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Pan181_47420	COG0110	maltose O-acetyltransferase activity
Pan181_47440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Pan181_47630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Pan181_47690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Pan181_47770	COG2801	Transposase and inactivated derivatives
Pan181_47870	COG2337	Toxic component of a toxin-antitoxin (TA) module
Pan181_47920	COG0506	proline dehydrogenase activity
Pan181_47920	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Pan181_47920	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Pan181_47980	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Pan181_48000	COG1331	Highly conserved protein containing a thioredoxin domain
Pan181_48030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Pan181_48090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Pan181_48110	COG1454	alcohol dehydrogenase
Pan181_48180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Pan181_48210	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_48220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Pan181_48310	COG3119	arylsulfatase activity
Pan181_48310	COG3408	Glycogen debranching enzyme
Pan181_48320	COG0686	Belongs to the AlaDH PNT family
Pan181_48340	COG4956	integral membrane protein (PIN domain superfamily)
Pan181_48360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Pan181_48490	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Pan181_48500	COG3408	Glycogen debranching enzyme
Pan181_48500	COG3119	arylsulfatase activity
Pan181_48510	COG1301	dicarboxylic acid transport
Pan181_48550	COG3123	guanosine phosphorylase activity
Pan181_48580	COG0574	Belongs to the PEP-utilizing enzyme family
Pan181_48580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Pan181_48600	COG4771	TonB-dependent receptor
Pan181_48690	COG2204	response regulator
Pan181_48760	COG2020	methyltransferase activity
Pan181_48810	COG0440	acetolactate synthase activity
Pan181_48820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Pan181_48830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Pan181_48840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Pan181_48850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Pan181_48860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Pan181_48910	COG0482	sulfurtransferase activity
Pan181_48920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Pan181_49060	COG0436	Aminotransferase
Pan181_49080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Pan181_49090	COG1776	CheC inhibitor of MCP methylation
Pan181_49090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_49140	COG0006	proline dipeptidase activity
Pan181_49150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan181_49150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan181_49170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan181_49170	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan181_49180	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan181_49200	COG0535	radical SAM domain protein
Pan181_49240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_49340	COG3119	arylsulfatase activity
Pan181_49370	COG3119	arylsulfatase activity
Pan181_49550	COG1609	Transcriptional regulator
Pan181_49550	COG2207	Transcriptional regulator
Pan181_49560	COG0697	spore germination
Pan181_49570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan181_49570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan181_49620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Pan181_49630	COG1216	Glycosyl transferase, family 2
Pan181_49670	COG4974	Belongs to the 'phage' integrase family
Pan181_49680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_49760	COG3335	DDE superfamily endonuclease
Pan181_49770	COG1446	asparaginase
Pan181_49780	COG0446	pyridine nucleotide-disulphide oxidoreductase
Pan181_49790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Pan181_49850	COG0840	transmembrane signaling receptor activity
Pan181_49860	COG2309	aminopeptidase activity
Pan181_49870	COG1960	acyl-CoA dehydrogenase activity
Pan181_49880	COG1137	ATPase activity
Pan181_49890	COG0681	Belongs to the peptidase S26 family
Pan181_49910	COG0438	transferase activity, transferring glycosyl groups
Pan181_49940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_49950	COG3437	response regulator, receiver
Pan181_49990	COG0017	Asparaginyl-tRNA synthetase
Pan181_50010	COG1966	Carbon starvation protein
Pan181_50020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_50030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Pan181_50040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Pan181_50060	COG4303	Ethanolamine ammonia lyase large subunit
Pan181_50100	COG0183	Belongs to the thiolase family
Pan181_50170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_50190	COG0505	Belongs to the CarA family
Pan181_50200	COG0436	Aminotransferase
Pan181_50310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Pan181_50330	COG0517	IMP dehydrogenase activity
Pan181_50330	COG0617	tRNA 3'-terminal CCA addition
Pan181_50330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Pan181_50440	COG3604	Transcriptional regulator
Pan181_50740	COG2815	serine threonine protein kinase
Pan181_50740	COG0515	serine threonine protein kinase
Pan181_50830	COG1285	pathogenesis
Pan181_50910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Pan181_50920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Pan181_50960	COG4977	sequence-specific DNA binding
Pan181_50990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Pan181_51000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_51010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Pan181_51100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Pan181_51160	COG1119	ATPase activity
Pan181_51170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Pan181_51210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_51290	COG1136	(ABC) transporter
Pan181_51290	COG0577	efflux transmembrane transporter activity
Pan181_51310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_51410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Pan181_51440	COG0822	iron-sulfur transferase activity
Pan181_51490	COG2815	serine threonine protein kinase
Pan181_51490	COG0515	serine threonine protein kinase
Pan181_51500	COG1272	protein, Hemolysin III
Pan181_51540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_51820	COG3250	beta-galactosidase activity
Pan181_51860	COG3537	Alpha-1,2-mannosidase
Pan181_51980	COG0659	secondary active sulfate transmembrane transporter activity
Pan181_52030	COG1733	regulation of RNA biosynthetic process
Pan181_52080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Pan181_52090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Pan181_52100	COG1120	ATPase activity
Pan181_52110	COG2226	methyltransferase
Pan181_52140	COG3119	arylsulfatase activity
Pan181_52150	COG0288	reversible hydration of carbon dioxide
Pan181_52180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Pan181_52190	COG2088	sporulation resulting in formation of a cellular spore
Pan181_52210	COG0114	fumarate hydratase activity
Pan181_52230	COG0288	reversible hydration of carbon dioxide
Pan181_52240	COG0793	Belongs to the peptidase S41A family
Pan181_52280	COG3386	PFAM SMP-30 Gluconolaconase
Pan181_52290	COG2084	Dehydrogenase
Pan181_52310	COG1760	l-serine dehydratase
Pan181_52350	COG0463	Glycosyl transferase, family 2
Pan181_52420	COG0714	Associated with various cellular activities
Pan181_52500	COG0438	transferase activity, transferring glycosyl groups
Pan181_52520	COG0628	permease
Pan181_52530	COG1940	carbohydrate kinase activity
Pan181_52550	COG2205	protein histidine kinase activity
Pan181_52550	COG0784	Response regulator, receiver
Pan181_52560	COG3293	Transposase
Pan181_52640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Pan181_52670	COG4067	protein conserved in archaea
Pan181_52670	COG0189	ligase activity
Pan181_52680	COG0569	domain protein
Pan181_52680	COG0189	ligase activity
Pan181_52820	COG0577	efflux transmembrane transporter activity
Pan181_52820	COG1136	(ABC) transporter
Pan181_52830	COG1136	(ABC) transporter
Pan181_52850	COG1063	alcohol dehydrogenase
Pan181_52860	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_52930	COG1595	DNA-templated transcription, initiation
Pan181_52950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Pan181_52990	COG3119	arylsulfatase activity
Pan181_53020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_53040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Pan181_53060	COG1132	(ABC) transporter
Pan181_53130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan181_53190	COG0072	phenylalanine-tRNA ligase activity
Pan181_53200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Pan181_53210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Pan181_53220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Pan181_53250	COG4864	UPF0365 protein
Pan181_53310	COG1136	(ABC) transporter
Pan181_53380	COG1030	water channel activity
Pan181_53400	COG1192	Involved in chromosome partitioning
Pan181_53430	COG1595	DNA-templated transcription, initiation
Pan181_53610	COG1834	amidinotransferase
Pan181_53670	COG1216	Glycosyl transferase, family 2
Pan181_53690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Pan181_53710	COG1301	dicarboxylic acid transport
Pan181_53730	COG1940	carbohydrate kinase activity
Pan181_53750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Pan181_53750	COG0517	IMP dehydrogenase activity
Pan181_53800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Pan181_53880	COG1283	sodium-dependent phosphate transmembrane transporter activity
Pan181_53890	COG0673	inositol 2-dehydrogenase activity
Pan181_53960	COG3534	alpha-L-arabinofuranosidase
Pan181_53970	COG0673	inositol 2-dehydrogenase activity
Pan181_54000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Pan181_54030	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_54070	COG1160	GTP binding
Pan181_54080	COG1573	uracil-dna glycosylase
Pan181_54090	COG0531	amino acid
Pan181_54120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Pan181_54140	COG1104	cysteine desulfurase activity