locus-tag	class	description
LDL78_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDL78_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDL78_00040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDL78_00045	COG0626	cystathionine gamma-synthase activity
LDL78_00050	COG1228	amidohydrolase
LDL78_00075	COG0488	(ABC) transporter
LDL78_00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDL78_00110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDL78_00115	COG1575	Belongs to the MenA family. Type 1 subfamily
LDL78_00155	COG0009	L-threonylcarbamoyladenylate synthase
LDL78_00175	COG0069	glutamate synthase activity
LDL78_00190	COG4585	Histidine kinase
LDL78_00210	COG0308	aminopeptidase N
LDL78_00215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDL78_00225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDL78_00235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDL78_00245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDL78_00265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDL78_00275	COG3956	TIGRFAM MazG family protein
LDL78_00285	COG0242	peptide deformylase activity
LDL78_00290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDL78_00310	COG0463	Glycosyl transferase, family 2
LDL78_00325	COG0463	Glycosyl transferase, family 2
LDL78_00335	COG1215	transferase activity, transferring glycosyl groups
LDL78_00340	COG0009	L-threonylcarbamoyladenylate synthase
LDL78_00350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDL78_00350	COG0617	tRNA 3'-terminal CCA addition
LDL78_00350	COG0517	IMP dehydrogenase activity
LDL78_00355	COG1612	heme a metabolic process
LDL78_00375	COG0514	ATP-dependent DNA helicase (RecQ)
LDL78_00380	COG0517	IMP dehydrogenase activity
LDL78_00380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LDL78_00385	COG0805	protein transport
LDL78_00395	COG1137	ATPase activity
LDL78_00420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDL78_00425	COG0438	transferase activity, transferring glycosyl groups
LDL78_00480	COG0438	transferase activity, transferring glycosyl groups
LDL78_00490	COG1215	transferase activity, transferring glycosyl groups
LDL78_00505	COG0438	transferase activity, transferring glycosyl groups
LDL78_00510	COG0438	transferase activity, transferring glycosyl groups
LDL78_00520	COG0438	transferase activity, transferring glycosyl groups
LDL78_00545	COG0463	Glycosyl transferase, family 2
LDL78_00545	COG1216	Glycosyl transferase, family 2
LDL78_00615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LDL78_00660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDL78_00665	COG0489	protein tyrosine kinase activity
LDL78_00665	COG3206	protein involved in exopolysaccharide biosynthesis
LDL78_00685	COG0488	(ABC) transporter
LDL78_00695	COG1136	(ABC) transporter
LDL78_00715	COG0653	protein targeting
LDL78_00750	COG1764	response to oxidative stress
LDL78_00770	COG1368	sulfuric ester hydrolase activity
LDL78_00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL78_00785	COG0463	Glycosyl transferase, family 2
LDL78_00800	COG0671	phosphoesterase, PA-phosphatase related
LDL78_00810	COG0534	Mate efflux family protein
LDL78_00885	COG2326	polyphosphate kinase activity
LDL78_00890	COG2204	response regulator
LDL78_00900	COG1668	transmembrane transport
LDL78_00905	COG4152	abc transporter atp-binding protein
LDL78_00910	COG0484	heat shock protein binding
LDL78_00915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDL78_00930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LDL78_00930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDL78_00940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDL78_00970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDL78_00995	COG1522	sequence-specific DNA binding
LDL78_01005	COG1703	isobutyryl-CoA mutase activity
LDL78_01005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDL78_01005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDL78_01025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDL78_01030	COG0284	orotidine-5'-phosphate decarboxylase activity
LDL78_01035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDL78_01045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDL78_01050	COG0823	Involved in the tonB-independent uptake of proteins
LDL78_01055	COG1462	curli production assembly transport component CsgG
LDL78_01100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDL78_01120	COG2264	protein methyltransferase activity
LDL78_01125	COG0149	triose-phosphate isomerase activity
LDL78_01130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_01135	COG0601	transmembrane transport
LDL78_01150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDL78_01155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LDL78_01160	COG1132	(ABC) transporter
LDL78_01165	COG0101	tRNA pseudouridine synthase activity
LDL78_01190	COG0494	nUDIX hydrolase
LDL78_01195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDL78_01205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LDL78_01205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LDL78_01210	COG0799	negative regulation of ribosome biogenesis
LDL78_01215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDL78_01225	COG4589	Belongs to the CDS family
LDL78_01230	COG0688	phosphatidylethanolamine metabolic process
LDL78_01245	COG0525	valine-tRNA ligase activity
LDL78_01260	COG0436	Aminotransferase
LDL78_01265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDL78_01280	COG1216	Glycosyl transferase, family 2
LDL78_01285	COG1595	DNA-templated transcription, initiation
LDL78_01290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDL78_01295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDL78_01300	COG0784	Response regulator, receiver
LDL78_01300	COG2198	Histidine kinase
LDL78_01300	COG2205	protein histidine kinase activity
LDL78_01305	COG1663	tetraacyldisaccharide 4'-kinase activity
LDL78_01310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDL78_01320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDL78_01360	COG3844	kynureninase activity
LDL78_01365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDL78_01380	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_01395	COG3104	oligopeptide transport
LDL78_01400	COG4122	O-methyltransferase activity
LDL78_01405	COG0671	phosphoesterase, PA-phosphatase related
LDL78_01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDL78_01435	COG3340	Belongs to the peptidase S51 family
LDL78_01450	COG1876	peptidase activity
LDL78_01455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LDL78_01475	COG2226	methyltransferase
LDL78_01485	COG1477	protein flavinylation
LDL78_01500	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL78_01510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL78_01515	COG1805	sodium ion transport
LDL78_01535	COG2967	ApaG domain
LDL78_01545	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_01555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_01580	COG0357	Ribosomal RNA small subunit methyltransferase G
LDL78_01585	COG3239	Fatty acid desaturase
LDL78_01590	COG0436	Aminotransferase
LDL78_01600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LDL78_01610	COG0569	domain protein
LDL78_01615	COG2226	methyltransferase
LDL78_01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL78_01635	COG0191	fructose-bisphosphate aldolase activity
LDL78_01640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LDL78_01650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDL78_01655	COG1185	polyribonucleotide nucleotidyltransferase activity
LDL78_01680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDL78_01690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDL78_01695	COG0492	ferredoxin-NADP+ reductase activity
LDL78_01700	COG3228	Belongs to the MtfA family
LDL78_01710	COG1629	transport
LDL78_01730	COG4206	TonB-dependent receptor
LDL78_01730	COG1629	transport
LDL78_01735	COG2217	Heavy metal translocating P-type atpase
LDL78_01740	COG0701	Predicted permease
LDL78_01750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDL78_01795	COG0138	bifunctional purine biosynthesis protein purh
LDL78_01800	COG1077	Cell shape determining protein MreB Mrl
LDL78_01815	COG0768	penicillin binding
LDL78_01820	COG0772	Belongs to the SEDS family
LDL78_01835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDL78_01845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDL78_01855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDL78_01865	COG0268	Binds directly to 16S ribosomal RNA
LDL78_01875	COG0442	prolyl-tRNA aminoacylation
LDL78_01890	COG0302	gtp cyclohydrolase
LDL78_01895	COG0215	cysteine-tRNA ligase activity
LDL78_01900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDL78_01905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDL78_01915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDL78_01955	COG0187	DNA topoisomerase II activity
LDL78_01965	COG0602	queuosine metabolic process
LDL78_01975	COG0433	COG0433 Predicted ATPase
LDL78_02010	COG3339	Conserved Protein
LDL78_02015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDL78_02025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LDL78_02035	COG3279	Response regulator of the LytR AlgR family
LDL78_02050	COG0531	amino acid
LDL78_02075	COG0798	PFAM Bile acid sodium symporter
LDL78_02090	COG0513	Belongs to the DEAD box helicase family
LDL78_02100	COG0745	RESPONSE REGULATOR receiver
LDL78_02115	COG1064	alcohol dehydrogenase
LDL78_02155	COG0288	reversible hydration of carbon dioxide
LDL78_02165	COG0018	arginyl-trna synthetase
LDL78_02170	COG2095	MarC family integral membrane protein
LDL78_02195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_02200	COG1477	protein flavinylation
LDL78_02220	COG1054	Belongs to the UPF0176 family
LDL78_02225	COG1054	Belongs to the UPF0176 family
LDL78_02235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_02240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDL78_02245	COG0512	Glutamine amidotransferase of anthranilate synthase
LDL78_02250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDL78_02255	COG0134	indole-3-glycerol-phosphate synthase activity
LDL78_02260	COG0135	phosphoribosylanthranilate isomerase activity
LDL78_02265	COG0133	tryptophan synthase activity
LDL78_02270	COG0159	tryptophan synthase activity
LDL78_02295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LDL78_02325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDL78_02335	COG3189	MarR family transcriptional regulator
LDL78_02370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LDL78_02375	COG2226	methyltransferase
LDL78_02390	COG0463	Glycosyl transferase, family 2
LDL78_02405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDL78_02420	COG1215	transferase activity, transferring glycosyl groups
LDL78_02435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDL78_02455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDL78_02465	COG0563	adenylate kinase activity
LDL78_02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDL78_02490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LDL78_02500	COG4221	oxidoreductase activity
LDL78_02535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDL78_02550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDL78_02555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDL78_02565	COG0339	signal peptide processing
LDL78_02590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDL78_02590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDL78_02595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDL78_02610	COG1785	Belongs to the alkaline phosphatase family
LDL78_02615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDL78_02645	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL78_02655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDL78_02675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDL78_02680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDL78_02700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LDL78_02730	COG0848	biopolymer transport protein
LDL78_02735	COG0811	peptide transport
LDL78_02750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LDL78_02755	COG1960	acyl-CoA dehydrogenase activity
LDL78_02770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDL78_02790	COG0745	RESPONSE REGULATOR receiver
LDL78_02790	COG2205	protein histidine kinase activity
LDL78_02790	COG3292	Two component regulator propeller
LDL78_02805	COG0321	lipoyl(octanoyl) transferase activity
LDL78_02830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDL78_02850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDL78_02855	COG0791	NLP P60 protein
LDL78_02855	COG1388	LysM domain
LDL78_02860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LDL78_02870	COG4585	Histidine kinase
LDL78_02900	COG0022	dehydrogenase e1 component
LDL78_02900	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL78_02910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDL78_02920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LDL78_02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDL78_02945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDL78_02950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LDL78_02965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDL78_02975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDL78_02985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDL78_02995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDL78_02995	COG1519	Transferase
LDL78_03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDL78_03100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDL78_03105	COG0628	permease
LDL78_03125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDL78_03150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDL78_03155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDL78_03165	COG0463	Glycosyl transferase, family 2
LDL78_03225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDL78_03230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDL78_03240	COG2204	response regulator
LDL78_03245	COG4191	Histidine kinase
LDL78_03285	COG0740	serine-type endopeptidase activity
LDL78_03310	COG0228	four-way junction DNA binding
LDL78_03315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDL78_03320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LDL78_03355	COG0633	Ferredoxin
LDL78_03360	COG0492	ferredoxin-NADP+ reductase activity
LDL78_03370	COG0489	protein tyrosine kinase activity
LDL78_03375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDL78_03385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDL78_03390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDL78_03395	COG5002	protein histidine kinase activity
LDL78_03400	COG0745	RESPONSE REGULATOR receiver
LDL78_03415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDL78_03435	COG0463	Glycosyl transferase, family 2
LDL78_03450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LDL78_03455	COG2363	Small membrane protein
LDL78_03465	COG2738	Putative neutral zinc metallopeptidase
LDL78_03470	COG0495	leucyl-tRNA aminoacylation
LDL78_03480	COG2177	Part of the ABC transporter FtsEX involved in
LDL78_03490	COG1968	undecaprenyl-diphosphatase activity
LDL78_03495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDL78_03505	COG0519	Catalyzes the synthesis of GMP from XMP
LDL78_03525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LDL78_03535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDL78_03555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDL78_03570	COG2205	protein histidine kinase activity
LDL78_03570	COG0784	Response regulator, receiver
LDL78_03585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDL78_03610	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LDL78_03620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDL78_03630	COG0436	Aminotransferase
LDL78_03635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LDL78_03655	COG1040	competence protein
LDL78_03665	COG0423	glycine-tRNA ligase activity
LDL78_03680	COG0708	Exodeoxyribonuclease III
LDL78_03685	COG0667	Aldo Keto reductase
LDL78_03690	COG1960	acyl-CoA dehydrogenase activity
LDL78_03695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LDL78_03700	COG4585	Histidine kinase
LDL78_03720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDL78_03725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDL78_03730	COG0297	glycogen (starch) synthase activity
LDL78_03740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDL78_03785	COG1530	ribonuclease E activity
LDL78_03790	COG0776	regulation of translation
LDL78_03800	COG0629	single-stranded DNA binding
LDL78_03820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDL78_03820	COG3743	rRNA binding
LDL78_03825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDL78_03850	COG1053	succinate dehydrogenase
LDL78_03885	COG0006	proline dipeptidase activity
LDL78_03890	COG2267	carboxylic ester hydrolase activity
LDL78_03900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LDL78_03920	COG1858	cytochrome C peroxidase
LDL78_03925	COG0316	Belongs to the HesB IscA family
LDL78_03930	COG0719	Fe-S assembly protein
LDL78_03940	COG0396	ATPase activity
LDL78_03945	COG0719	Fe-S assembly protein
LDL78_03950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDL78_03960	COG2166	iron-sulfur cluster assembly
LDL78_03965	COG2151	metal-sulfur cluster biosynthetic enzyme
LDL78_03980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDL78_04020	COG4771	TonB-dependent receptor
LDL78_04035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LDL78_04040	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LDL78_04050	COG0322	excinuclease ABC activity
LDL78_04060	COG4206	TonB-dependent receptor
LDL78_04065	COG0189	ligase activity
LDL78_04070	COG0189	ligase activity
LDL78_04070	COG4067	protein conserved in archaea
LDL78_04075	COG0189	ligase activity
LDL78_04085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDL78_04100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDL78_04110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDL78_04170	COG2855	membrane
LDL78_04175	COG0668	transmembrane transport
LDL78_04230	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_04235	COG1247	-acetyltransferase
LDL78_04240	COG1381	Involved in DNA repair and RecF pathway recombination
LDL78_04250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDL78_04260	COG1054	Belongs to the UPF0176 family
LDL78_04265	COG1774	PSP1 C-terminal conserved region
LDL78_04275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LDL78_04280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDL78_04290	COG4172	Belongs to the ABC transporter superfamily
LDL78_04320	COG1253	flavin adenine dinucleotide binding
LDL78_04335	COG0113	porphobilinogen synthase activity
LDL78_04345	COG0408	coproporphyrinogen oxidase activity
LDL78_04350	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LDL78_04365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDL78_04375	COG0569	domain protein
LDL78_04380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDL78_04385	COG0181	hydroxymethylbilane synthase activity
LDL78_04390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDL78_04405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDL78_04420	COG1981	membrane
LDL78_04425	COG5000	phosphorelay sensor kinase activity
LDL78_04430	COG1024	Enoyl-CoA hydratase
LDL78_04435	COG0071	Belongs to the small heat shock protein (HSP20) family
LDL78_04450	COG1418	mRNA catabolic process
LDL78_04470	COG0484	heat shock protein binding
LDL78_04475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL78_04475	COG1321	iron dependent repressor
LDL78_04480	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDL78_04485	COG1121	(ABC) transporter
LDL78_04490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL78_04495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL78_04515	COG1999	signal sequence binding
LDL78_04560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL78_04570	COG3590	peptidase
LDL78_04585	COG0516	GMP reductase activity
LDL78_04585	COG0517	IMP dehydrogenase activity
LDL78_04595	COG0629	single-stranded DNA binding
LDL78_04615	COG2183	response to ionizing radiation
LDL78_04625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL78_04625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL78_04630	COG1619	proteins homologs of microcin C7 resistance protein MccF
LDL78_04635	COG0792	nuclease activity
LDL78_04645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDL78_04665	COG1201	RNA secondary structure unwinding
LDL78_04670	COG1793	dna ligase
LDL78_04685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LDL78_04695	COG0527	aspartate kinase activity
LDL78_04725	COG0346	lactoylglutathione lyase activity
LDL78_04730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDL78_04745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDL78_04750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDL78_04755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDL78_04760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDL78_04765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDL78_04770	COG0356	it plays a direct role in the translocation of protons across the membrane
LDL78_04830	COG0151	Belongs to the GarS family
LDL78_04855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL78_04860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDL78_04895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDL78_04900	COG2089	acid synthase
LDL78_04945	COG4942	peptidase
LDL78_04945	COG1388	LysM domain
LDL78_04950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDL78_04960	COG1388	LysM domain
LDL78_04960	COG0791	NLP P60 protein
LDL78_04965	COG0126	phosphoglycerate kinase activity
LDL78_04980	COG0445	tRNA wobble uridine modification
LDL78_04985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDL78_04995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDL78_05055	COG0557	exoribonuclease II activity
LDL78_05065	COG0698	ribose 5-phosphate isomerase
LDL78_05075	COG2153	protein acetylation
LDL78_05095	COG0793	Belongs to the peptidase S41A family
LDL78_05105	COG0594	ribonuclease P activity
LDL78_05120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDL78_05125	COG3263	regulation of cellular component size
LDL78_05135	COG0481	GTPase activity
LDL78_05150	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDL78_05155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDL78_05175	COG0307	riboflavin synthase, alpha
LDL78_05180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDL78_05190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDL78_05195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDL78_05200	COG0511	ligase activity, forming carbon-carbon bonds
LDL78_05205	COG0439	Biotin carboxylase
LDL78_05215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDL78_05230	COG1289	transmembrane transporter activity
LDL78_05235	COG2130	NADP-dependent
LDL78_05240	COG3842	ATPase activity
LDL78_05255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDL78_05270	COG0659	secondary active sulfate transmembrane transporter activity
LDL78_05280	COG0659	secondary active sulfate transmembrane transporter activity
LDL78_05305	COG2304	oxidoreductase activity
LDL78_05310	COG2304	oxidoreductase activity
LDL78_05325	COG0714	Associated with various cellular activities
LDL78_05345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDL78_05355	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_05370	COG1446	asparaginase
LDL78_05385	COG4953	penicillin-binding protein 1C
LDL78_05395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL78_05415	COG2954	triphosphatase activity
LDL78_05425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDL78_05435	COG0469	pyruvate kinase activity
LDL78_05445	COG0571	ribonuclease III activity
LDL78_05450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDL78_05455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDL78_05465	COG0328	RNA-DNA hybrid ribonuclease activity
LDL78_05465	COG3341	Caulimovirus viroplasmin
LDL78_05475	COG1105	Belongs to the carbohydrate kinase PfkB family
LDL78_05485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDL78_05490	COG1074	ATP-dependent DNA helicase activity
LDL78_05495	COG0156	8-amino-7-oxononanoate synthase activity
LDL78_05500	COG2885	chlorophyll binding
LDL78_05535	COG0720	synthase
LDL78_05545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDL78_05545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LDL78_05565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LDL78_05580	COG1435	thymidine kinase activity
LDL78_05585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDL78_05595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDL78_05605	COG1505	serine-type exopeptidase activity
LDL78_05615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDL78_05620	COG0194	GDP metabolic process
LDL78_05625	COG1561	YicC-like family, N-terminal region
LDL78_05630	COG0429	hydrolase of the alpha beta-hydrolase fold
LDL78_05640	COG0697	spore germination
LDL78_05655	COG0626	cystathionine gamma-synthase activity
LDL78_05680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDL78_05700	COG0180	Tryptophanyl-tRNA synthetase
LDL78_05705	COG0758	DNA mediated transformation
LDL78_05705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDL78_05715	COG1607	acyl-coa hydrolase
LDL78_05740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LDL78_05745	COG0756	dUTP diphosphatase activity
LDL78_05760	COG2239	Acts as a magnesium transporter
LDL78_05765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDL78_05795	COG2095	MarC family integral membrane protein
LDL78_05805	COG0793	Belongs to the peptidase S41A family
LDL78_05880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDL78_05885	COG1061	Type III restriction enzyme res subunit
LDL78_05890	COG1002	Type II restriction enzyme, methylase subunits
LDL78_05910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDL78_05915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDL78_05920	COG0193	aminoacyl-tRNA hydrolase activity
LDL78_05925	COG0196	riboflavin kinase activity
LDL78_05935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDL78_05945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDL78_05945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDL78_05990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LDL78_06000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDL78_06010	COG1278	Cold shock
LDL78_06020	COG0038	chloride channel
LDL78_06025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDL78_06060	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL78_06070	COG4585	Histidine kinase
LDL78_06080	COG0084	hydrolase, TatD family'
LDL78_06085	COG0252	asparaginase activity
LDL78_06095	COG0811	peptide transport
LDL78_06125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LDL78_06130	COG0017	Asparaginyl-tRNA synthetase
LDL78_06155	COG0233	cytoplasmic translational termination
LDL78_06160	COG0528	UMP kinase activity
LDL78_06170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDL78_06175	COG0052	Belongs to the universal ribosomal protein uS2 family
LDL78_06180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDL78_06185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDL78_06195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDL78_06195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDL78_06205	COG4242	Belongs to the peptidase S51 family
LDL78_06210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDL78_06210	COG0189	ligase activity
LDL78_06220	COG3118	belongs to the thioredoxin family
LDL78_06255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDL78_06270	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_06275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDL78_06280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDL78_06295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDL78_06300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL78_06320	COG1131	(ABC) transporter
LDL78_06335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDL78_06350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDL78_06380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL78_06415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LDL78_06425	COG0589	response to stress
LDL78_06430	COG0779	Required for maturation of 30S ribosomal subunits
LDL78_06435	COG0195	Participates in both transcription termination and antitermination
LDL78_06440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDL78_06450	COG4654	Cytochrome c, class I
LDL78_06455	COG0437	4 iron, 4 sulfur cluster binding
LDL78_06460	COG0052	Belongs to the universal ribosomal protein uS2 family
LDL78_06460	COG3743	rRNA binding
LDL78_06480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDL78_06485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDL78_06490	COG2255	four-way junction helicase activity
LDL78_06500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LDL78_06510	COG0632	four-way junction helicase activity
LDL78_06520	COG0509	glycine decarboxylation via glycine cleavage system
LDL78_06550	COG0109	protoheme IX farnesyltransferase activity
LDL78_06555	COG1845	cytochrome c oxidase, subunit III
LDL78_06560	COG1845	cytochrome c oxidase, subunit III
LDL78_06575	COG1999	signal sequence binding
LDL78_06580	COG2322	membrane
LDL78_06590	COG1136	(ABC) transporter
LDL78_06595	COG1136	(ABC) transporter
LDL78_06595	COG0577	efflux transmembrane transporter activity
LDL78_06600	COG1136	(ABC) transporter
LDL78_06600	COG0577	efflux transmembrane transporter activity
LDL78_06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL78_06635	COG0668	transmembrane transport
LDL78_06640	COG1331	Highly conserved protein containing a thioredoxin domain
LDL78_06675	COG3275	phosphorelay sensor kinase activity
LDL78_06680	COG3279	Response regulator of the LytR AlgR family
LDL78_06685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LDL78_06690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDL78_06710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDL78_06720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDL78_06730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LDL78_06735	COG0596	Alpha beta hydrolase
LDL78_06750	COG1950	PFAM Membrane protein of
LDL78_06755	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDL78_06765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDL78_06785	COG1428	Deoxynucleoside kinase
LDL78_06790	COG1187	pseudouridine synthase activity
LDL78_06800	COG0010	Belongs to the arginase family
LDL78_06805	COG1899	peptidyl-lysine modification to peptidyl-hypusine
LDL78_06810	COG3153	acetyltransferase
LDL78_06810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDL78_06830	COG0459	protein refolding
LDL78_06835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDL78_06860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDL78_06880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDL78_06910	COG0488	(ABC) transporter
LDL78_06915	COG1752	Esterase of the alpha-beta hydrolase superfamily
LDL78_06955	COG2824	Alkylphosphonate utilization operon protein PhnA
LDL78_06990	COG1475	DNA binding
LDL78_07035	COG0629	single-stranded DNA binding
LDL78_07040	COG0629	single-stranded DNA binding
LDL78_07070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDL78_07155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDL78_07190	COG2217	Heavy metal translocating P-type atpase
LDL78_07205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDL78_07210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LDL78_07215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDL78_07235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDL78_07240	COG3174	membrane
LDL78_07245	COG0205	6-phosphofructokinase activity
LDL78_07255	COG1830	Aldolase
LDL78_07345	COG2132	Multicopper oxidase
LDL78_07365	COG0701	Predicted permease
LDL78_07405	COG0347	Belongs to the P(II) protein family
LDL78_07420	COG2217	Heavy metal translocating P-type atpase
LDL78_07425	COG2217	Heavy metal translocating P-type atpase
LDL78_07455	COG0076	glutamate decarboxylase activity
LDL78_07460	COG2081	HI0933 family
LDL78_07490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDL78_07495	COG4558	Periplasmic binding protein
LDL78_07510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDL78_07520	COG1902	pentaerythritol trinitrate reductase activity
LDL78_07525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDL78_07535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDL78_07545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDL78_07545	COG1333	cytochrome c biogenesis protein
LDL78_07570	COG0492	ferredoxin-NADP+ reductase activity
LDL78_07640	COG1629	transport
LDL78_07665	COG0084	hydrolase, TatD family'
LDL78_07710	COG1309	transcriptional regulator
LDL78_07720	COG0697	spore germination
LDL78_07735	COG2318	DinB family
LDL78_07740	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_07760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LDL78_07775	COG3275	phosphorelay sensor kinase activity
LDL78_07785	COG0006	proline dipeptidase activity
LDL78_07825	COG3609	addiction module antidote protein, CC2985 family
LDL78_07860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDL78_07895	COG0778	Nitroreductase
LDL78_07935	COG0456	acetyltransferase
LDL78_07950	COG1131	(ABC) transporter
LDL78_07970	COG3279	Response regulator of the LytR AlgR family
LDL78_07975	COG3275	phosphorelay sensor kinase activity
LDL78_07995	COG4251	negative regulation of phosphorylation
LDL78_08000	COG2201	protein-glutamate methylesterase activity
LDL78_08020	COG2169	Transcriptional regulator
LDL78_08035	COG2378	regulation of single-species biofilm formation
LDL78_08040	COG0534	Mate efflux family protein
LDL78_08045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDL78_08050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LDL78_08055	COG3174	membrane
LDL78_08065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDL78_08070	COG1428	Deoxynucleoside kinase
LDL78_08105	COG3186	Phenylalanine-4-hydroxylase
LDL78_08115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDL78_08120	COG3396	Phenylacetate-CoA oxygenase
LDL78_08130	COG3460	Phenylacetate-CoA oxygenase
LDL78_08140	COG3396	Phenylacetate-CoA oxygenase
LDL78_08145	COG2151	metal-sulfur cluster biosynthetic enzyme
LDL78_08150	COG1024	Enoyl-CoA hydratase
LDL78_08155	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDL78_08170	COG2321	neutral zinc metallopeptidase
LDL78_08175	COG0183	Belongs to the thiolase family
LDL78_08180	COG2030	dehydratase
LDL78_08180	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_08200	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL78_08205	COG0022	dehydrogenase e1 component
LDL78_08225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDL78_08235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDL78_08245	COG1160	GTP binding
LDL78_08265	COG1704	LemA family
LDL78_08280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDL78_08310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDL78_08330	COG0646	methionine synthase
LDL78_08330	COG1410	methionine synthase
LDL78_08335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDL78_08345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDL78_08375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LDL78_08385	COG1162	GTPase activity
LDL78_08390	COG1490	D-aminoacyl-tRNA deacylase activity
LDL78_08405	COG1694	Mazg nucleotide pyrophosphohydrolase
LDL78_08420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDL78_08430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LDL78_08435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDL78_08460	COG0358	DNA primase activity
LDL78_08465	COG2197	response regulator
LDL78_08470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDL78_08485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LDL78_08495	COG2001	Belongs to the MraZ family
LDL78_08500	COG0275	rRNA processing
LDL78_08510	COG0768	penicillin binding
LDL78_08515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDL78_08520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDL78_08525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDL78_08530	COG0772	Belongs to the SEDS family
LDL78_08535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDL78_08540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDL78_08555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDL78_08560	COG1610	YqeY-like protein
LDL78_08580	COG2003	Belongs to the UPF0758 family
LDL78_08590	COG1011	Hydrolase
LDL78_08610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDL78_08620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL78_08635	COG1629	transport
LDL78_08645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDL78_08650	COG0049	tRNA binding
LDL78_08655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDL78_08660	COG0051	transcription antitermination factor activity, RNA binding
LDL78_08665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDL78_08670	COG0088	Forms part of the polypeptide exit tunnel
LDL78_08675	COG0089	rRNA binding
LDL78_08680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDL78_08685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDL78_08690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDL78_08695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDL78_08700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDL78_08705	COG0255	Belongs to the universal ribosomal protein uL29 family
LDL78_08710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDL78_08715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDL78_08720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDL78_08725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDL78_08730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDL78_08735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDL78_08740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDL78_08750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDL78_08755	COG1841	ribosomal large subunit assembly
LDL78_08760	COG0200	Binds to the 23S rRNA
LDL78_08765	COG0201	protein transport
LDL78_08770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDL78_08775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDL78_08780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDL78_08785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDL78_08790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDL78_08795	COG0202	RNA polymerase activity
LDL78_08800	COG0203	ribosomal protein L17
LDL78_08805	COG0505	Belongs to the CarA family
LDL78_08810	COG0148	phosphopyruvate hydratase activity
LDL78_08830	COG3104	oligopeptide transport
LDL78_08845	COG0658	competence protein
LDL78_08845	COG2333	competence protein COMEC
LDL78_08850	COG0791	NLP P60 protein
LDL78_08855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL78_08860	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDL78_08870	COG0564	pseudouridine synthase activity
LDL78_08880	COG3401	FG-GAP repeat protein
LDL78_08890	COG3591	Belongs to the peptidase S1B family
LDL78_08895	COG2354	Protein conserved in bacteria
LDL78_08920	COG0488	(ABC) transporter
LDL78_08950	COG3263	regulation of cellular component size
LDL78_08970	COG3022	response to hydroperoxide
LDL78_08985	COG0339	signal peptide processing
LDL78_08995	COG4717	serine-type aminopeptidase activity
LDL78_09045	COG1595	DNA-templated transcription, initiation
LDL78_09060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LDL78_09085	COG4095	Psort location CytoplasmicMembrane, score
LDL78_09095	COG3685	Protein conserved in bacteria
LDL78_09140	COG0300	oxidoreductase activity
LDL78_09175	COG2949	membrane
LDL78_09180	COG4452	Inner membrane protein CreD
LDL78_09200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LDL78_09205	COG1217	gtp-binding protein TYPA
LDL78_09285	COG0438	transferase activity, transferring glycosyl groups
LDL78_09295	COG0463	Glycosyl transferase, family 2
LDL78_09295	COG1216	Glycosyl transferase, family 2
LDL78_09315	COG2884	Cell division ATP-binding protein ftsE
LDL78_09325	COG1943	Transposase
LDL78_09340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDL78_09350	COG3876	Protein conserved in bacteria
LDL78_09355	COG0577	efflux transmembrane transporter activity
LDL78_09380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDL78_09385	COG1115	amino acid carrier protein
LDL78_09390	COG1596	polysaccharide export
LDL78_09390	COG1555	photosystem II stabilization
LDL78_09395	COG1960	acyl-CoA dehydrogenase activity
LDL78_09405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LDL78_09410	COG4974	Belongs to the 'phage' integrase family
LDL78_09415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDL78_09450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDL78_09460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDL78_09465	COG0081	regulation of translation
LDL78_09470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDL78_09475	COG0222	ribosome binding
LDL78_09480	COG0085	RNA polymerase activity
LDL78_09485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDL78_09495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDL78_09510	COG2885	chlorophyll binding
LDL78_09515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LDL78_09525	COG1482	cell wall glycoprotein biosynthetic process
LDL78_09545	COG0596	Alpha beta hydrolase
LDL78_09560	COG1404	Belongs to the peptidase S8 family
LDL78_09560	COG4935	Belongs to the peptidase S8 family
LDL78_09565	COG0326	Molecular chaperone. Has ATPase activity
LDL78_09575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDL78_09580	COG0823	Involved in the tonB-independent uptake of proteins
LDL78_09580	COG1506	peptidase
LDL78_09585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDL78_09600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDL78_09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDL78_09620	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL78_09625	COG2176	DNA-directed DNA polymerase activity
LDL78_09625	COG5002	protein histidine kinase activity
LDL78_09630	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDL78_09640	COG1058	Belongs to the CinA family
LDL78_09640	COG1546	Belongs to the CinA family
LDL78_09645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDL78_09650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDL78_09660	COG0552	protein localization to endoplasmic reticulum
LDL78_09665	COG0823	Involved in the tonB-independent uptake of proteins
LDL78_09665	COG1506	peptidase
LDL78_09670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDL78_09705	COG4974	Belongs to the 'phage' integrase family
LDL78_09735	COG0038	chloride channel
LDL78_09785	COG0556	nucleotide-excision repair
LDL78_09800	COG1187	pseudouridine synthase activity
LDL78_09805	COG0071	Belongs to the small heat shock protein (HSP20) family
LDL78_09820	COG0045	succinate-CoA ligase (ADP-forming) activity
LDL78_09825	COG0019	diaminopimelate decarboxylase activity
LDL78_09845	COG1404	Belongs to the peptidase S8 family
LDL78_09850	COG0482	sulfurtransferase activity
LDL78_09860	COG0706	membrane insertase activity
LDL78_09865	COG0504	CTP synthase activity
LDL78_09875	COG3530	Putative quorum-sensing-regulated virulence factor
LDL78_09890	COG1388	LysM domain
LDL78_09890	COG3942	CHAP domain
LDL78_09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDL78_09895	COG0519	Catalyzes the synthesis of GMP from XMP
LDL78_09900	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LDL78_09920	COG1704	LemA family
LDL78_09930	COG2304	oxidoreductase activity
LDL78_09945	COG1131	(ABC) transporter
LDL78_09960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDL78_09965	COG2318	DinB family
LDL78_09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL78_10000	COG0659	secondary active sulfate transmembrane transporter activity
LDL78_10015	COG1132	(ABC) transporter
LDL78_10025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDL78_10035	COG1862	Preprotein translocase
LDL78_10040	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDL78_10045	COG0167	dihydroorotate dehydrogenase activity
LDL78_10050	COG1280	lysine exporter protein (LysE YggA)
LDL78_10055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDL78_10060	COG0737	Belongs to the 5'-nucleotidase family
LDL78_10090	COG0516	GMP reductase activity
LDL78_10090	COG0517	IMP dehydrogenase activity
LDL78_10105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDL78_10115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDL78_10120	COG0714	Associated with various cellular activities
LDL78_10130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_10175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDL78_10180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LDL78_10195	COG3958	Transketolase
LDL78_10200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDL78_10205	COG0343	queuine tRNA-ribosyltransferase activity
LDL78_10220	COG0825	malonyl-CoA metabolic process
LDL78_10225	COG0305	Participates in initiation and elongation during chromosome replication
LDL78_10235	COG2885	chlorophyll binding
LDL78_10240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDL78_10245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDL78_10250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDL78_10255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDL78_10290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDL78_10310	COG0335	large ribosomal subunit rRNA binding
LDL78_10315	COG0336	Belongs to the RNA methyltransferase TrmD family
LDL78_10355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDL78_10360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDL78_10370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LDL78_10375	COG2234	aminopeptidase activity
LDL78_10385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDL78_10385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDL78_10400	COG0562	UDP-galactopyranose mutase
LDL78_10425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDL78_10440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDL78_10460	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_10480	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_10485	COG1192	Involved in chromosome partitioning
LDL78_10490	COG1475	DNA binding
LDL78_10500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDL78_10510	COG2133	pyrroloquinoline quinone binding
LDL78_10520	COG0439	Biotin carboxylase
LDL78_10525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDL78_10530	COG0730	response to heat
LDL78_10555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDL78_10560	COG1127	ABC transporter
LDL78_10585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDL78_10590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDL78_10620	COG2988	succinylglutamate desuccinylase activity
LDL78_10625	COG0189	ligase activity
LDL78_10660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL78_10685	COG0589	response to stress
LDL78_10690	COG0813	purine-nucleoside phosphorylase activity
LDL78_10695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LDL78_10715	COG2205	protein histidine kinase activity
LDL78_10720	COG0745	RESPONSE REGULATOR receiver
LDL78_10755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDL78_10795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LDL78_10800	COG4263	nitrous-oxide reductase activity
LDL78_10820	COG1131	(ABC) transporter
LDL78_10845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDL78_10850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDL78_10860	COG0427	acetyl-CoA hydrolase
LDL78_10885	COG2217	Heavy metal translocating P-type atpase
LDL78_10905	COG2010	Cytochrome c
LDL78_10910	COG0348	domain, Protein
LDL78_10940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDL78_10955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDL78_10965	COG0492	ferredoxin-NADP+ reductase activity
LDL78_11020	COG0714	Associated with various cellular activities
LDL78_11055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDL78_11090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LDL78_11105	COG3655	Transcriptional regulator
LDL78_11120	COG3275	phosphorelay sensor kinase activity
LDL78_11140	COG3279	Response regulator of the LytR AlgR family
LDL78_11200	COG0037	tRNA processing
LDL78_11205	COG0205	6-phosphofructokinase activity
LDL78_11220	COG0166	Belongs to the GPI family
LDL78_11225	COG0606	chelatase, subunit chli
LDL78_11230	COG0612	Peptidase, M16
LDL78_11260	COG4585	Histidine kinase
LDL78_11265	COG2197	response regulator
LDL78_11270	COG0564	pseudouridine synthase activity
LDL78_11275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDL78_11285	COG1760	l-serine dehydratase
LDL78_11300	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_11310	COG0443	Heat shock 70 kDa protein
LDL78_11330	COG2050	protein possibly involved in aromatic compounds catabolism
LDL78_11335	COG1169	isochorismate synthase
LDL78_11340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDL78_11380	COG0367	asparagine synthase
LDL78_11390	COG0022	dehydrogenase e1 component
LDL78_11410	COG1611	Belongs to the LOG family
LDL78_11425	COG0405	Gamma-glutamyltransferase
LDL78_11440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDL78_11460	COG0705	Rhomboid family
LDL78_11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_11495	COG0783	Belongs to the Dps family
LDL78_11515	COG0529	Catalyzes the synthesis of activated sulfate
LDL78_11525	COG0175	sulfate reduction
LDL78_11550	COG2244	polysaccharide biosynthetic process
LDL78_11565	COG1216	Glycosyl transferase, family 2
LDL78_11565	COG0463	Glycosyl transferase, family 2
LDL78_11580	COG0438	transferase activity, transferring glycosyl groups
LDL78_11590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDL78_11655	COG3177	Filamentation induced by cAMP protein fic
LDL78_11700	COG2201	protein-glutamate methylesterase activity
LDL78_11775	COG1104	cysteine desulfurase activity
LDL78_11790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDL78_11815	COG1074	ATP-dependent DNA helicase activity
LDL78_11840	COG4771	TonB-dependent receptor
LDL78_11890	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_11895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDL78_11900	COG0587	DNA-directed DNA polymerase activity
LDL78_11915	COG4585	Histidine kinase
LDL78_11940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDL78_11945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDL78_11970	COG0095	Lipoate-protein ligase
LDL78_11980	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LDL78_11985	COG1047	Peptidyl-prolyl cis-trans
LDL78_11995	COG2353	YceI-like domain
LDL78_12000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDL78_12005	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_12010	COG3384	dioxygenase
LDL78_12015	COG2259	Doxx family
LDL78_12025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDL78_12035	COG0592	DNA-directed DNA polymerase activity
LDL78_12060	COG1702	phosphate starvation-inducible protein PhoH
LDL78_12065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDL78_12080	COG1115	amino acid carrier protein
LDL78_12095	COG1363	Peptidase, m42
LDL78_12140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDL78_12145	COG0116	Belongs to the methyltransferase superfamily
LDL78_12145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LDL78_12160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDL78_12165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDL78_12195	COG1104	cysteine desulfurase activity
LDL78_12225	COG1418	mRNA catabolic process
LDL78_12230	COG0656	L-ascorbic acid biosynthetic process
LDL78_12235	COG4974	Belongs to the 'phage' integrase family
LDL78_12260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDL78_12265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDL78_12270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDL78_12275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDL78_12290	COG2270	Major facilitator Superfamily
LDL78_12305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDL78_12315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDL78_12320	COG1970	mechanosensitive ion channel activity
LDL78_12345	COG1522	sequence-specific DNA binding
LDL78_12360	COG0693	protein deglycase activity
LDL78_12370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDL78_12385	COG0686	Belongs to the AlaDH PNT family
LDL78_12405	COG0802	atpase or kinase
LDL78_12410	COG2204	response regulator
LDL78_12415	COG1078	dGTPase activity
LDL78_12420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL78_12425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL78_12425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LDL78_12430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL78_12435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDL78_12450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LDL78_12455	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_12470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDL78_12475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDL78_12480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDL78_12485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDL78_12490	COG0131	Imidazoleglycerol-phosphate dehydratase
LDL78_12490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDL78_12500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDL78_12515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDL78_12515	COG0140	phosphoribosyl-ATP diphosphatase activity
LDL78_12520	COG0598	Magnesium transport protein CorA
LDL78_12530	COG4181	ATPase activity
LDL78_12535	COG0577	efflux transmembrane transporter activity
LDL78_12535	COG1136	(ABC) transporter
LDL78_12545	COG3239	Fatty acid desaturase
LDL78_12550	COG1278	Cold shock
LDL78_12580	COG0586	Pfam SNARE associated Golgi protein
LDL78_12675	COG1136	(ABC) transporter
LDL78_12690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDL78_12710	COG0574	Belongs to the PEP-utilizing enzyme family
LDL78_12710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDL78_12720	COG2205	protein histidine kinase activity
LDL78_12730	COG0071	Belongs to the small heat shock protein (HSP20) family
LDL78_12810	COG2116	formate transmembrane transporter activity
LDL78_12850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDL78_12860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL78_12865	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_12875	COG2226	methyltransferase
LDL78_12900	COG0022	dehydrogenase e1 component
LDL78_12915	COG0813	purine-nucleoside phosphorylase activity
LDL78_12925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDL78_12935	COG3011	Protein conserved in bacteria
LDL78_12945	COG1301	dicarboxylic acid transport
LDL78_12950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDL78_12960	COG0247	lactate metabolic process
LDL78_12960	COG0277	FAD linked oxidase domain protein
LDL78_12970	COG0438	transferase activity, transferring glycosyl groups
LDL78_12975	COG1472	Belongs to the glycosyl hydrolase 3 family
LDL78_12985	COG0247	lactate metabolic process
LDL78_12985	COG2181	nitrate reductase activity
LDL78_12995	COG0247	lactate metabolic process
LDL78_12995	COG2181	nitrate reductase activity
LDL78_13000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDL78_13005	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDL78_13015	COG0251	oxidation-reduction process
LDL78_13025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDL78_13040	COG0628	permease
LDL78_13070	COG0183	Belongs to the thiolase family
LDL78_13075	COG0791	NLP P60 protein
LDL78_13080	COG0457	Tetratricopeptide repeat
LDL78_13090	COG0542	response to heat
LDL78_13105	COG2986	histidine ammonia-lyase
LDL78_13110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDL78_13135	COG2197	response regulator
LDL78_13150	COG0697	spore germination
LDL78_13155	COG0513	Belongs to the DEAD box helicase family
LDL78_13160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDL78_13165	COG4628	conserved protein (DUF2132)
LDL78_13175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDL78_13210	COG2353	YceI-like domain
LDL78_13220	COG1741	Belongs to the pirin family
LDL78_13270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDL78_13275	COG0471	metal ion transport
LDL78_13275	COG3273	potassium ion transport
LDL78_13280	COG0668	transmembrane transport
LDL78_13295	COG0300	oxidoreductase activity
LDL78_13305	COG1196	nuclear chromosome segregation
LDL78_13305	COG3264	Mechanosensitive ion channel
LDL78_13310	COG2814	Major facilitator Superfamily
LDL78_13315	COG0668	transmembrane transport
LDL78_13340	COG1012	belongs to the aldehyde dehydrogenase family
LDL78_13345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDL78_13350	COG2066	Belongs to the glutaminase family
LDL78_13360	COG2154	pterin-4-alpha-carbinolamine dehydratase
LDL78_13365	COG0217	transcriptional regulatory protein
LDL78_13380	COG1454	alcohol dehydrogenase
LDL78_13395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDL78_13425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDL78_13455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDL78_13465	COG0259	pyridoxamine-phosphate oxidase activity
LDL78_13470	COG1234	tRNA 3'-trailer cleavage
LDL78_13480	COG0540	Belongs to the ATCase OTCase family
LDL78_13485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LDL78_13505	COG0484	heat shock protein binding
LDL78_13520	COG0012	GTP binding
LDL78_13540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDL78_13550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDL78_13555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDL78_13580	COG4771	TonB-dependent receptor
LDL78_13590	COG0302	gtp cyclohydrolase
LDL78_13595	COG1136	(ABC) transporter
LDL78_13605	COG2205	protein histidine kinase activity
LDL78_13605	COG0784	Response regulator, receiver
LDL78_13620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDL78_13645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LDL78_13655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDL78_13660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LDL78_13675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDL78_13705	COG0456	acetyltransferase
LDL78_13710	COG0156	8-amino-7-oxononanoate synthase activity
LDL78_13725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LDL78_13785	COG1393	Belongs to the ArsC family
LDL78_13805	COG1333	cytochrome c biogenesis protein
LDL78_13805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDL78_13830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDL78_13840	COG0424	maF-like protein
LDL78_13870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDL78_13870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDL78_13885	COG0047	phosphoribosylformylglycinamidine synthase activity
LDL78_13885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDL78_13925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL78_13985	COG1022	Amp-dependent synthetase and ligase
LDL78_13995	COG2076	Multidrug Resistance protein
LDL78_14005	COG1024	Enoyl-CoA hydratase
LDL78_14005	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDL78_14015	COG0183	Belongs to the thiolase family
LDL78_14025	COG1960	acyl-CoA dehydrogenase activity
LDL78_14055	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LDL78_14060	COG1652	LysM domain
LDL78_14060	COG2823	Periplasmic or secreted lipoprotein
LDL78_14145	COG1757	Na H antiporter
LDL78_14150	COG0450	alkyl hydroperoxide reductase
LDL78_14155	COG3118	belongs to the thioredoxin family
LDL78_14165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LDL78_14185	COG1674	ftsk spoiiie
LDL78_14200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDL78_14200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDL78_14205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDL78_14220	COG4974	Belongs to the 'phage' integrase family
LDL78_14305	COG1629	transport
LDL78_14315	COG0823	Involved in the tonB-independent uptake of proteins
LDL78_14315	COG1506	peptidase
LDL78_14330	COG1609	Transcriptional regulator
LDL78_14330	COG2207	Transcriptional regulator
LDL78_14340	COG0156	8-amino-7-oxononanoate synthase activity
LDL78_14375	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDL78_14485	COG0629	single-stranded DNA binding
LDL78_14515	COG1459	type II secretion system
LDL78_14530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDL78_14630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDL78_14670	COG1595	DNA-templated transcription, initiation
LDL78_14695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDL78_14700	COG1120	ATPase activity
LDL78_14720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDL78_14725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDL78_14755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDL78_14760	COG4166	transmembrane transport
LDL78_14775	COG0254	rRNA binding
LDL78_14790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDL78_14795	COG1132	(ABC) transporter
LDL78_14825	COG1028	Short-chain dehydrogenase reductase Sdr
LDL78_14830	COG0415	Belongs to the DNA photolyase family
LDL78_14845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDL78_14855	COG2921	Belongs to the UPF0250 family
LDL78_14865	COG0514	ATP-dependent DNA helicase (RecQ)
LDL78_14870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDL78_14880	COG1678	Uncharacterized ACR, COG1678
LDL78_14915	COG0124	histidyl-tRNA synthetase
LDL78_14920	COG0577	efflux transmembrane transporter activity
LDL78_14930	COG0359	binds to the 23S rRNA
LDL78_14935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDL78_14940	COG0360	Binds together with S18 to 16S ribosomal RNA
LDL78_14945	COG3279	Response regulator of the LytR AlgR family
LDL78_14950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDL78_14960	COG1295	ribonuclease BN
LDL78_14970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LDL78_15000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDL78_15000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDL78_15010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDL78_15020	COG0572	uridine kinase
LDL78_15045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDL78_15055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDL78_15065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDL78_15080	COG0105	UTP biosynthetic process
LDL78_15085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDL78_15095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDL78_15100	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDL78_15135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL78_15140	COG0501	Belongs to the peptidase M48B family
LDL78_15165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LDL78_15190	COG0488	(ABC) transporter
LDL78_15200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDL78_15205	COG0300	oxidoreductase activity
LDL78_15235	COG0590	tRNA wobble adenosine to inosine editing
LDL78_15245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDL78_15265	COG0542	response to heat
LDL78_15300	COG3237	CsbD-like
LDL78_15310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDL78_15330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDL78_15335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDL78_15345	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDL78_15355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDL78_15365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDL78_15370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDL78_15385	COG0237	dephospho-CoA kinase activity
LDL78_15395	COG0463	Glycosyl transferase, family 2
LDL78_15395	COG1216	Glycosyl transferase, family 2
LDL78_15415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LDL78_15420	COG0497	DNA recombination
LDL78_15445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDL78_15455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDL78_15460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDL78_15465	COG1611	Belongs to the LOG family
LDL78_15470	COG2890	protein-(glutamine-N5) methyltransferase activity
LDL78_15475	COG0456	acetyltransferase
LDL78_15480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDL78_15480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDL78_15485	COG0697	spore germination
LDL78_15490	COG1739	Uncharacterized protein family UPF0029