locus-tag class description AP3564_00170 ENOG4105C0P Mg chelatase subunit ChlI AP3564_00235 ENOG4105E2K Glycosyl transferase (Group 1 AP3564_00250 ENOG4107V0Z fmn reductase AP3564_00280 ENOG4105C32 Amino acid ABC transporter (Permease) AP3564_00285 ENOG4108IV0 ABC, transporter AP3564_00290 ENOG4105C0Z ABC transporter AP3564_00305 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AP3564_00310 ENOG4108Z7G MaoC domain protein dehydratase AP3564_00315 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_00345 ENOG4108JPW Aminotransferase AP3564_00350 ENOG4105C26 Dehydrogenase AP3564_00370 ENOG4105CE4 GlcNAc 6-P deacetylase AP3564_00375 ENOG410904A RNA polymerase AP3564_00385 ENOG4105DA5 (ABC) transporter AP3564_00415 ENOG4105CIG ABC transporter AP3564_00435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_00440 ENOG4105BZU Histidine kinase AP3564_00450 ENOG4105CHR reductase AP3564_00455 ENOG4105EMD TRANSCRIPTIONal AP3564_00465 ENOG410787A Pts system, glucitol sorbitol-specific AP3564_00470 ENOG4105DZY Pts system, glucitol sorbitol-specific AP3564_00480 ENOG4108V06 Glutathione peroxidase AP3564_00485 ENOG41069FQ Metallo-beta-lactamase superfamily AP3564_00490 ENOG4105RWS endonuclease I AP3564_00505 ENOG4105CTS PTS system mannitol-specific AP3564_00510 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) AP3564_00515 ENOG4105DT3 PTS system, galactitol-specific IIc component AP3564_00520 ENOG4105CPQ Dehydrogenase AP3564_00530 ENOG4105CPQ Dehydrogenase AP3564_00550 ENOG4105CSH Transporter AP3564_00555 ENOG4105C5I Dehydrogenase AP3564_00565 ENOG4106P55 Transcriptional regulator AP3564_00590 ENOG4105DTN riboflavin biosynthesis protein ribF AP3564_00595 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AP3564_00600 ENOG4105ERH Fumarylacetoacetate hydrolase AP3564_00615 ENOG4105C26 Dehydrogenase AP3564_00625 ENOG4105C26 Dehydrogenase AP3564_00645 ENOG4105C32 Amino acid ABC transporter (Permease) AP3564_00650 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AP3564_00655 ENOG4105C0Z ABC transporter AP3564_00660 ENOG4108IV0 ABC, transporter AP3564_00665 ENOG4105FUY alpha subunit AP3564_00700 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AP3564_00715 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AP3564_00720 ENOG4105C7N Xanthine uracil vitamin C permease AP3564_00725 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AP3564_00730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AP3564_00735 ENOG4105C83 adenylosuccinate lyase AP3564_00740 ENOG4105C8V SAICAR synthetase AP3564_00745 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AP3564_00750 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AP3564_00755 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AP3564_00765 ENOG4105CXB phosphoribosylaminoimidazole synthetase AP3564_00770 ENOG4108V3E phosphoribosylglycinamide formyltransferase AP3564_00775 ENOG4105DC1 bifunctional purine biosynthesis protein purh AP3564_00790 ENOG4105C12 Phosphoribosylglycinamide synthetase AP3564_00800 ENOG4108R5T secreted protein AP3564_00805 ENOG4105KGF protein, YerC YecD AP3564_00810 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) AP3564_00815 ENOG4105C4R Atp-dependent dna helicase AP3564_00825 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AP3564_00845 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AP3564_00850 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AP3564_00855 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AP3564_00860 ENOG4105CBD Diacylglycerol kinase AP3564_00865 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AP3564_00895 ENOG4105CVR type I restriction-modification system AP3564_00920 ENOG4105C1J atp-dependent rna helicase AP3564_00925 ENOG4105E5H Transposase AP3564_00945 ENOG4107QRT dEAD DEAH box helicase AP3564_00955 ENOG4107QJE Chromosome Partitioning Protein AP3564_00980 ENOG4107QJE Chromosome Partitioning Protein AP3564_01030 ENOG4105CRW Short chain fatty acid transporter AP3564_01035 ENOG4105CMU LysR family (Transcriptional regulator AP3564_01040 ENOG4105CSH Transporter AP3564_01055 ENOG41067SE Tetr family transcriptional regulator AP3564_01060 ENOG4105CJ1 ABC, transporter AP3564_01095 ENOG4105DWT malate dehydrogenase (quinone) AP3564_01100 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AP3564_01105 ENOG4105DCF alanine dehydrogenase AP3564_01110 ENOG4108K8K Transcriptional regulator AP3564_01115 ENOG4105CDA abc transporter atp-binding protein AP3564_01125 ENOG4105S6R Iron-hydroxamate transporter permease subunit AP3564_01145 ENOG4105CDA abc transporter atp-binding protein AP3564_01150 ENOG4105E5Q amino acid AbC transporter AP3564_01155 ENOG4105EAB amino acid AbC transporter AP3564_01165 ENOG41060BG Tetr family transcriptional regulator AP3564_01180 ENOG4105FB9 CRISPR-associated protein AP3564_01200 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AP3564_01205 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) AP3564_01210 ENOG4105C8Q Methyl-accepting chemotaxis AP3564_01225 ENOG4105NCW Trka-c domain protein AP3564_01230 ENOG4107S91 Sodium hydrogen exchanger AP3564_01240 ENOG4105CHU acetyl-coa acetyltransferase AP3564_01245 ENOG4105C0R drug resistance transporter emrb qaca subfamily AP3564_01250 ENOG4105YA8 Transcriptional regulator AP3564_01255 ENOG4105DWK Membrane AP3564_01275 ENOG4105ETE Transcriptional regulator (LacI family AP3564_01280 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AP3564_01285 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AP3564_01295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AP3564_01300 ENOG4105F38 ABC transporter, permease AP3564_01305 ENOG4105D38 putrescine abc transporter AP3564_01310 ENOG4107RUE extracellular solute-binding protein family 1 AP3564_01330 ENOG4105BZ1 (ABC) transporter AP3564_01340 ENOG410667J hydrolase AP3564_01345 ENOG4108Z1Z gCN5-related N-acetyltransferase AP3564_01350 ENOG4105DHS permease protein AP3564_01355 ENOG4105CM4 permease protein AP3564_01360 ENOG4108IPW abc transporter atp-binding protein AP3564_01390 ENOG4105EXQ uroporphyrinogen iii synthase hem4 AP3564_01405 ENOG4108IJ9 (ABC) transporter AP3564_01410 ENOG4105DRS transport system, permease AP3564_01415 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AP3564_01420 ENOG4108IJG ABC transporter substrate-binding protein AP3564_01425 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AP3564_01430 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AP3564_01445 ENOG4105KVH Transcriptional regulator AP3564_01460 ENOG4105C1G acyl-Coa dehydrogenase AP3564_01480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AP3564_01485 ENOG4105ES4 Nitrilase AP3564_01490 ENOG4105DTQ mandelate racemase muconate lactonizing AP3564_01520 ENOG41068PA UPF0435 protein AP3564_01525 ENOG4105KJF protein tyrosine phosphatase AP3564_01535 ENOG4107U9T Pfam:Ribonuclease_BN AP3564_01560 ENOG4105ECB domain protein AP3564_01585 ENOG4105UPD Calcium Proton AP3564_01620 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate AP3564_01625 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) AP3564_01630 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AP3564_01635 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AP3564_01640 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AP3564_01645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AP3564_01650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AP3564_01675 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AP3564_01705 ENOG4105DQ6 Transposase AP3564_01855 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AP3564_01890 ENOG4105C5Y PTS System AP3564_01895 ENOG4108Q3X Transcriptional regulator AP3564_01900 ENOG4105F8D glycoside hydrolase family 4 AP3564_01905 ENOG4105CI1 PTS System AP3564_02000 ENOG4105CTX dehydratase AP3564_02020 ENOG41073TP transcriptional regulator AP3564_02035 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AP3564_02045 ENOG4108RZE Tetr family transcriptional regulator AP3564_02050 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain AP3564_02070 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AP3564_02075 ENOG4105CPU Monooxygenase AP3564_02105 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AP3564_02140 ENOG4105KK4 UPF0060 membrane protein AP3564_02150 ENOG4105D2S major facilitator superfamily AP3564_02170 ENOG4107TXC Transcriptional regulator AP3564_02180 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AP3564_02200 ENOG4105C28 cystathionine AP3564_02205 ENOG4105KAC Antibiotic biosynthesis monooxygenase AP3564_02245 ENOG4107RSM transcriptional regulator AP3564_02250 ENOG4105F27 Major Facilitator AP3564_02255 ENOG4105CSV Glutaminase AP3564_02265 ENOG4105C0H protease AP3564_02270 ENOG4105DJB Major Facilitator Superfamily AP3564_02280 ENOG4107RSM transcriptional regulator AP3564_02285 ENOG4108ZCF integral membrane protein AP3564_02315 ENOG410902V Modulates RecA activity (By similarity) AP3564_02325 ENOG4105XHU Acid-soluble spore protein K AP3564_02330 ENOG41067AE Membrane-bound metal-dependent hydrolase AP3564_02335 ENOG4105CEN a g-specific adenine glycosylase AP3564_02345 ENOG4105CAN Short-chain dehydrogenase reductase Sdr AP3564_02355 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AP3564_02365 ENOG4105EVI UPF0374 protein AP3564_02370 ENOG4105BZ1 (ABC) transporter AP3564_02380 ENOG4107NBY Membrane AP3564_02385 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AP3564_02390 ENOG4108IUW ABC transporter AP3564_02410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_02415 ENOG4105G5W regulator Fur family AP3564_02420 ENOG4105TUA UPF0295 protein AP3564_02520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AP3564_02550 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AP3564_02555 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AP3564_02560 ENOG4108JUB Transcriptional regulator AP3564_02565 ENOG4105CMT Dihydroxyacetone kinase AP3564_02580 ENOG4105KRI phosphocarrier protein (HPr AP3564_02595 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AP3564_02620 ENOG4108Z40 Transcriptional regulator AP3564_02625 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AP3564_02630 ENOG4105DEN Luciferase family AP3564_02650 ENOG4105DBE peroxidase AP3564_02655 ENOG410650H (LipO)protein AP3564_02660 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AP3564_02665 ENOG4107RUY (E1 component), alpha subunit AP3564_02675 ENOG4107QKR Dehydrogenase AP3564_02680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AP3564_02695 ENOG4105C26 Dehydrogenase AP3564_02710 ENOG4105EJJ Dehydrogenase AP3564_02715 ENOG4105IE8 Alpha-ketoglutarate permease AP3564_02725 ENOG4105E98 transcriptional regulator DeoR family AP3564_02730 ENOG4108UZX fmn reductase AP3564_02735 ENOG4105DXX methyltransferase AP3564_02765 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AP3564_02785 ENOG4105CYN Serine protein kinase AP3564_02790 ENOG4106AKX UPF0229 protein AP3564_02805 ENOG4107ZYJ bioY protein AP3564_02810 ENOG4107F3J Amp-dependent synthetase and ligase AP3564_02815 ENOG4105CHU acetyl-coa acetyltransferase AP3564_02820 ENOG4107T5V SNARE associated Golgi AP3564_02830 ENOG4105DYS nad(p)h dehydrogenase (quinone) AP3564_02850 ENOG41080XP Cbs domain AP3564_02865 ENOG4105KPV Transcriptional regulator AP3564_02875 ENOG4105ED1 spovr family AP3564_02880 ENOG4108ZCF integral membrane protein AP3564_02895 ENOG4108REF Sporulation integral membrane protein ytvi AP3564_02900 ENOG4105C02 permease AP3564_02915 ENOG4105WMR Protein CrcB homolog AP3564_02925 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AP3564_02930 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AP3564_02955 ENOG4105C0Z ABC transporter AP3564_02960 ENOG4108IV0 ABC, transporter AP3564_02970 ENOG4106YBV Methyl-accepting chemotaxis AP3564_02995 ENOG410839P AP3564_03000 ENOG410839P AP3564_03015 ENOG4108UH6 UPF0754 membrane protein AP3564_03020 ENOG4105E1K spore germination protein AP3564_03040 ENOG4105WZB UPF0342 protein AP3564_03045 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AP3564_03050 ENOG4105E2R ROK family AP3564_03060 ENOG4105D4P Coproporphyrinogen iii oxidase AP3564_03075 ENOG4107VRP DNA repair exonuclease AP3564_03080 ENOG4106D4I domain protein AP3564_03085 ENOG4105EQI Metal Dependent Phosphohydrolase AP3564_03095 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AP3564_03130 ENOG4105NBU tryptophan transport protein AP3564_03135 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AP3564_03140 ENOG4105K59 histidine triad (HIT) protein AP3564_03155 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AP3564_03160 ENOG4105BZ4 penicillin-binding protein AP3564_03165 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AP3564_03170 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AP3564_03175 ENOG4105C1Q protoporphyrinogen oxidase AP3564_03185 ENOG4106AXD AP3564_03190 ENOG4108RQ5 Beta-lactamase domain-containing protein AP3564_03200 ENOG4105C7J ABC transporter, permease AP3564_03210 ENOG4108JCI Transcriptional regulator AP3564_03215 ENOG4108UMN azlc family AP3564_03225 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AP3564_03235 ENOG4105DFU Cell wall formation (By similarity) AP3564_03240 ENOG4105C88 aminopeptidase AP3564_03260 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AP3564_03265 ENOG4105ETE Transcriptional regulator (LacI family AP3564_03270 ENOG4105DGU Histone deacetylase AP3564_03275 ENOG4105W87 Cbs domain AP3564_03280 ENOG4105F1V Acetoin utilization protein AP3564_03305 ENOG4105CNA YD repeat protein AP3564_03515 ENOG4106KNT transcriptional regulator AP3564_03525 ENOG4105CPQ Dehydrogenase AP3564_03530 ENOG41061GT Aldolase AP3564_03555 ENOG4105C8M UPF0272 protein AP3564_03560 ENOG4105C5I Dehydrogenase AP3564_03600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AP3564_03605 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AP3564_03610 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AP3564_03620 ENOG4105CPQ Dehydrogenase AP3564_03625 ENOG41061GT Aldolase AP3564_03640 ENOG4105C5I Dehydrogenase AP3564_03650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AP3564_03660 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AP3564_03675 ENOG4105K64 Glycosyl transferase, family 2 AP3564_03715 ENOG4105DQ4 alcohol dehydrogenase AP3564_03725 ENOG4108PTS heparinase ii AP3564_03735 ENOG4105D3Q Sugar transferase AP3564_03740 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AP3564_03745 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AP3564_03750 ENOG4107YJ4 chain length determinant protein AP3564_03755 ENOG4105HTX biosynthesis protein AP3564_03760 ENOG4105KBK Zinc finger, swim domain protein AP3564_03765 ENOG4105C0D helicase AP3564_03770 ENOG4105Z8H single-stranded DNA-binding protein AP3564_03780 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR AP3564_03805 ENOG4105CGA flagellar basal-body rod protein FlgG AP3564_03815 ENOG4105DFF Rod shape-determining protein mreb AP3564_03820 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AP3564_03835 ENOG4105E7W lamb ycsf family protein AP3564_03840 ENOG4105P4J Allophanate hydrolase, subunit 1 AP3564_03845 ENOG4107TCE N-acetyltransferase AP3564_03850 ENOG4105FRN stage II sporulation protein AP3564_03865 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AP3564_03875 ENOG4106778 Protein of unknown function (DUF1146) AP3564_03880 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AP3564_03885 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AP3564_03890 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AP3564_03895 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AP3564_03900 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AP3564_03905 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AP3564_03910 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AP3564_03915 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AP3564_03920 ENOG41062M3 atp synthase AP3564_03930 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AP3564_03940 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AP3564_03945 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AP3564_03955 ENOG4108YZG isomerase AP3564_03960 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AP3564_03965 ENOG4107WAU Protein tyrosine phosphatase AP3564_03970 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AP3564_03975 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AP3564_03985 ENOG4108ZXQ stage ii sporulation protein r AP3564_03990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AP3564_03995 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AP3564_04010 ENOG4107104 thymidine kinase AP3564_04015 ENOG41082DI 50s ribosomal protein l31 AP3564_04020 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AP3564_04025 ENOG4105CBT Fructose-1,6-bisphosphatase AP3564_04030 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AP3564_04035 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AP3564_04040 ENOG4105D2N Aldolase AP3564_04045 ENOG410812K response regulator receiver protein AP3564_04055 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AP3564_04065 ENOG4105DF6 Fe-S oxidoreductase AP3564_04070 ENOG4105EMN RNA polymerase sigma factor AP3564_04075 ENOG4105C75 arginyL-tRNA synthetase AP3564_04080 ENOG410684U Domain of unknown function (DUF1934) AP3564_04085 ENOG4105CYW agmatinase AP3564_04090 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AP3564_04095 ENOG4105BZ4 penicillin-binding protein AP3564_04100 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AP3564_04105 ENOG4108QCI YvbH-like oligomerisation region AP3564_04110 ENOG4108VCI transcription factor, rsfa family AP3564_04115 ENOG4105QAT UPF0741 protein AP3564_04120 ENOG4105DCI Phosphohydrolase AP3564_04130 ENOG4108Z4T Peptidase M50 AP3564_04135 ENOG4108XFG YwhD family AP3564_04140 ENOG4108IJ2 phosphate acetyltransferase AP3564_04145 ENOG4107JTW chlorite dismutase AP3564_04150 ENOG4108VKI Cell wall hydrolase AP3564_04160 ENOG4107RQ2 Cytochrome c oxidase, subunit I AP3564_04165 ENOG4105NAA Cytochrome C oxidase, subunit II AP3564_04200 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AP3564_04220 ENOG4105DWF phosphomethylpyrimidine kinase AP3564_04225 ENOG4105DAP Nicotinate phosphoribosyltransferase AP3564_04230 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AP3564_04240 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AP3564_04245 ENOG41060D1 Quinol oxidase AP3564_04260 ENOG4105E2S oxidase) subunit II AP3564_04265 ENOG4108DBC nitroreductase AP3564_04270 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AP3564_04280 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AP3564_04285 ENOG4106PMH Extracellular solute-binding protein family 3 AP3564_04290 ENOG4105E5Q amino acid AbC transporter AP3564_04305 ENOG4108X4Q Hydrolase AP3564_04310 ENOG4107YBY Hydrolase AP3564_04340 ENOG4108IV0 ABC, transporter AP3564_04345 ENOG4105C0Z ABC transporter AP3564_04355 ENOG4105C32 Amino acid ABC transporter (Permease) AP3564_04360 ENOG4105CAD extracellular ligand-binding receptor AP3564_04380 ENOG4105CPP Dehydrogenase, E1 component AP3564_04385 ENOG4107RUY (E1 component), alpha subunit AP3564_04430 ENOG4107T9Q phosphonate abc transporter AP3564_04435 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AP3564_04455 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AP3564_04460 ENOG4105CJZ response regulator AP3564_04465 ENOG4105EWM Histidine kinase AP3564_04470 ENOG4105C19 ABC transporter AP3564_04475 ENOG4108HVR ABC transporter, permease AP3564_04480 ENOG4108RYK Nad-dependent epimerase dehydratase AP3564_04485 ENOG4108Z40 Transcriptional regulator AP3564_04515 ENOG4105CJ1 ABC, transporter AP3564_04520 ENOG4105E1J oxidoreductase AP3564_04530 ENOG4108S4H thioesterase Superfamily protein AP3564_04535 ENOG4105CAY ferredoxin--nadp reductase AP3564_04540 ENOG4105CMU LysR family (Transcriptional regulator AP3564_04570 ENOG4105EEM helicase AP3564_04575 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AP3564_04585 ENOG4105BZU Histidine kinase AP3564_04605 ENOG4105DZR Type I site-specific deoxyribonuclease AP3564_04610 ENOG4105EKX Restriction modification system DNA (Specificity AP3564_04615 ENOG4105CVR type I restriction-modification system AP3564_04630 ENOG4105E98 transcriptional regulator DeoR family AP3564_04640 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AP3564_04650 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AP3564_04655 ENOG4105ENY Ethanolamine utilization protein eutH AP3564_04665 ENOG4105E98 transcriptional regulator DeoR family AP3564_04685 ENOG41079K6 HNH endonuclease AP3564_04700 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AP3564_04710 ENOG4105C0H protease AP3564_04715 ENOG4105Q2H domain protein AP3564_04730 ENOG4105BZU Histidine kinase AP3564_04735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_04750 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AP3564_04755 ENOG4105CDU Replicative dna helicase AP3564_04760 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AP3564_04765 ENOG4105BZR domain protein AP3564_04770 ENOG4108XMW Membrane AP3564_04775 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AP3564_04780 ENOG4108UUM single-stranded DNA-binding protein AP3564_04785 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AP3564_04790 ENOG4105C3G gtp-binding protein AP3564_04795 ENOG4105VDK protein, conserved in bacteria AP3564_04800 ENOG4108ZDA Sporulation protein YyaC AP3564_04805 ENOG4105FA0 parb-like partition protein AP3564_04810 ENOG4107QJE Chromosome Partitioning Protein AP3564_04820 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) AP3564_04825 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AP3564_04830 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AP3564_04835 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AP3564_04840 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein AP3564_04845 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AP3564_04850 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AP3564_04855 ENOG4105VG0 50S ribosomal protein l34 AP3564_04865 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AP3564_04870 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AP3564_04875 ENOG410848D S4 domain protein YaaA AP3564_04880 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AP3564_04885 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AP3564_04890 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AP3564_04895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AP3564_04930 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AP3564_04950 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AP3564_04955 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AP3564_04960 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AP3564_04965 ENOG4105D5U fad dependent oxidoreductase AP3564_04985 ENOG4105VRS hydrolase family 18 AP3564_04990 ENOG4108Z6B deaminase AP3564_05000 ENOG4105C6E dna polymerase iii AP3564_05005 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AP3564_05010 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AP3564_05020 ENOG41067KS pro-sigma K processing AP3564_05045 ENOG4105CXN decarboxylase AP3564_05050 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AP3564_05055 ENOG4105X0R protein from nitrogen regulatory protein P-II AP3564_05060 ENOG4105XVJ Protein of unknown function (DUF327) AP3564_05065 ENOG4105FA2 dna polymerase iii AP3564_05070 ENOG4105MA4 psp1 domain protein AP3564_05075 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) AP3564_05080 ENOG41060K3 Methyltransferase AP3564_05085 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AP3564_05090 ENOG4105KRN Transcriptional regulator, abrb family AP3564_05100 ENOG4105F8V Hydrolase, tatD family AP3564_05105 ENOG41069ER domain protein AP3564_05115 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AP3564_05120 ENOG4105XFA sporulation peptidase YabG AP3564_05125 ENOG4105W42 Veg protein AP3564_05130 ENOG4105XEW small acid-soluble spore protein AP3564_05135 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AP3564_05140 ENOG4105DFT pur operon repressor AP3564_05145 ENOG4105KME endoribonuclease L-psp AP3564_05155 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AP3564_05160 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AP3564_05165 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AP3564_05170 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AP3564_05180 ENOG4108JA2 transcriptioN-repair coupling factor AP3564_05185 ENOG4108M14 stage v sporulation protein t AP3564_05205 ENOG4105D7V transposase AP3564_05215 ENOG4108IY2 MazG family AP3564_05220 ENOG41082I2 s4 domain protein AP3564_05225 ENOG4105VYY sporulation protein yabp AP3564_05240 ENOG41060GV RNA binding s1 domain protein AP3564_05270 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AP3564_05275 ENOG4108UGV hypoxanthine phosphoribosyltransferase AP3564_05280 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AP3564_05285 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AP3564_05290 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AP3564_05295 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase AP3564_05300 ENOG4105C6T cysteine synthase AP3564_05305 ENOG4105CRQ synthase (Component I) AP3564_05310 ENOG4105DDQ anthranilate synthase AP3564_05315 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AP3564_05320 ENOG4105EEI dihydropteroate synthase AP3564_05325 ENOG4105KRF dihydroneopterin aldolase AP3564_05330 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AP3564_05340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AP3564_05345 ENOG4105CRK lysyL-tRNA synthetase AP3564_05450 ENOG4105DA5 (ABC) transporter AP3564_05470 ENOG4105E5H Transposase AP3564_05505 ENOG4106A3R peptidase AP3564_05535 ENOG4105CZX twitching motility protein AP3564_05540 ENOG4107QHF type ii secretion system protein e AP3564_05565 ENOG4105KT7 mgtC SapB transporter AP3564_05575 ENOG4108Z0C Uvrb UvrC protein AP3564_05580 ENOG41066A3 ATP guanido phosphotransferase AP3564_05590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AP3564_05595 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AP3564_05600 ENOG4105CTP PilT protein domain protein AP3564_05605 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AP3564_05610 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AP3564_05615 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AP3564_05620 ENOG4105D7W serine acetyltransferase AP3564_05625 ENOG4105C8N cysteinyl-tRNA synthetase AP3564_05630 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AP3564_05635 ENOG4105C2N RNA methyltransferase TrmH family group 3 AP3564_05640 ENOG4105M0M Tetracycline resistance protein AP3564_05645 ENOG4105QIV RNA polymerase AP3564_05655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AP3564_05665 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AP3564_05670 ENOG4108VZM 50s ribosomal protein L10 AP3564_05675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AP3564_05680 ENOG4107Y49 methyltransferase AP3564_05685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AP3564_05690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AP3564_05695 ENOG4105XPM ribosomal protein AP3564_05700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AP3564_05705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AP3564_05710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AP3564_05715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AP3564_05720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AP3564_05725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AP3564_05730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AP3564_05735 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AP3564_05740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AP3564_05745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AP3564_05750 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AP3564_05755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AP3564_05760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AP3564_05765 ENOG41082SA 50s ribosomal protein l29 AP3564_05770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AP3564_05775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AP3564_05780 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AP3564_05785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AP3564_05790 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AP3564_05795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AP3564_05800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AP3564_05805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AP3564_05810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AP3564_05820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AP3564_05825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AP3564_05830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AP3564_05835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AP3564_05845 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AP3564_05855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AP3564_05860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AP3564_05870 ENOG4108ZT0 50S ribosomal protein l17 AP3564_05875 ENOG4108JJB ABC transporter AP3564_05880 ENOG4108JJB ABC transporter AP3564_05885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AP3564_05890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AP3564_05895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AP3564_05900 ENOG4108UJD 30S ribosomal protein S9 AP3564_05940 ENOG4105D1F ATP-binding protein AP3564_05960 ENOG4108NMV polysaccharide deacetylase AP3564_06040 ENOG4107TXC Transcriptional regulator AP3564_06045 ENOG4105EMN RNA polymerase sigma factor AP3564_06055 ENOG4105C8B TIGR00159 family AP3564_06060 ENOG4107U5W ybbr family AP3564_06065 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AP3564_06070 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AP3564_06085 ENOG4105C37 (CBS) domain AP3564_06110 ENOG4105FBW Monooxygenase AP3564_06115 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AP3564_06140 ENOG4105D7K pfkb domain protein AP3564_06150 ENOG41080HJ 6-phospho 3-hexuloisomerase AP3564_06155 ENOG4105DG4 malate L-lactate dehydrogenase AP3564_06160 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit AP3564_06170 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AP3564_06175 ENOG4105CPQ Dehydrogenase AP3564_06180 ENOG4108UHU Aldolase AP3564_06185 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AP3564_06190 ENOG4105DMW Dehydrogenase reductase AP3564_06235 ENOG4105C85 amino acid AP3564_06250 ENOG4105EA8 2-Nitropropane dioxygenase AP3564_06265 ENOG4105CQB FAD linked oxidase domain protein AP3564_06270 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AP3564_06275 ENOG4105CQB FAD linked oxidase domain protein AP3564_06280 ENOG4105C82 Malate synthase AP3564_06290 ENOG4105J4Q Transcriptional regulator AP3564_06295 ENOG4105DAA L-lactate AP3564_06300 ENOG4105XTG Pfam:DUF156 AP3564_06310 ENOG4105EAB amino acid AbC transporter AP3564_06315 ENOG4105E5Q amino acid AbC transporter AP3564_06320 ENOG4105CDA abc transporter atp-binding protein AP3564_06340 ENOG410814C multidrug resistance protein AP3564_06345 ENOG4107E54 Small Multidrug Resistance protein AP3564_06355 ENOG4105DKG l-rhamnose isomerase AP3564_06360 ENOG4105CMG Carbohydrate kinase AP3564_06365 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AP3564_06375 ENOG4105C2F Histidine kinase AP3564_06380 ENOG41075H3 AraC family transcriptional regulator AP3564_06385 ENOG4105DJV ribulose-phosphate 3-epimerase AP3564_06390 ENOG4108RVA ribokinase AP3564_06395 ENOG4105C2J ABC transporter AP3564_06400 ENOG4105CNN ABC, transporter AP3564_06405 ENOG4105F5R ABC transporter AP3564_06410 ENOG4105D4B ABC, transporter AP3564_06415 ENOG4105DET Rhamnulokinase AP3564_06440 ENOG4108WUZ (ABC) transporter AP3564_06445 ENOG41066N6 Abortive infection protein AP3564_06450 ENOG4107ZBH radical SAM domain protein AP3564_06460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AP3564_06510 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AP3564_06540 ENOG4105DEN Luciferase family AP3564_06545 ENOG4105NBF ammecr1 domain protein AP3564_06560 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AP3564_06580 ENOG41069M3 Transcriptional regulator AP3564_06590 ENOG4105ECY inositol monophosphatase AP3564_06595 ENOG41073TP transcriptional regulator AP3564_06600 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AP3564_06615 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AP3564_06635 ENOG4107RKG DJ-1/PfpI family AP3564_06645 ENOG4105DEN Luciferase family AP3564_06655 ENOG4105DJ2 Major Facilitator Superfamily AP3564_06675 ENOG4105DJ2 Major Facilitator Superfamily AP3564_06680 ENOG4108IJ9 (ABC) transporter AP3564_06685 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AP3564_06690 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AP3564_06695 ENOG4105BZ7 extracellular solute-binding protein family 1 AP3564_06700 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AP3564_06705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_06710 ENOG4105BZU Histidine kinase AP3564_06715 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AP3564_06720 ENOG4108Q5U germination protein, ger(x)c family AP3564_06730 ENOG4105CBC glutamate synthase AP3564_06740 ENOG4105CM2 brancheD-chain amino acid aminotransferase AP3564_06745 ENOG4105U0R haloacid dehalogenase-like hydrolase AP3564_06750 ENOG4105SZ6 Thioredoxin AP3564_06755 ENOG4105CPF Cell wall formation (By similarity) AP3564_06760 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AP3564_06765 ENOG4105C1J atp-dependent rna helicase AP3564_06770 ENOG410905X membrane-flanked domain protein AP3564_06775 ENOG4105CKV Membrane AP3564_06785 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AP3564_06790 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AP3564_06805 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AP3564_06815 ENOG4107MMM Anti-sigma-factor antagonist AP3564_06820 ENOG4105FUA antagonist AP3564_06825 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AP3564_06830 ENOG4107SGM protein serine threonine phosphatase AP3564_06835 ENOG4105WN5 stage II sporulation protein AP3564_06840 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AP3564_06850 ENOG41064BQ Phosphatase AP3564_06940 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AP3564_06945 ENOG4105K8N protein family UPF0079, ATPase AP3564_06950 ENOG41072GX Peptidase M22 Glycoprotease AP3564_06955 ENOG410801F ribosomal-protein-alanine acetyltransferase AP3564_06960 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AP3564_06965 ENOG4105C5H ABC transporter AP3564_06970 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AP3564_06975 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AP3564_06980 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AP3564_06990 ENOG4108TYN CAAX amino terminal protease family protein AP3564_06995 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AP3564_07000 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AP3564_07005 ENOG4105NX3 Membrane AP3564_07040 ENOG4107TRE AP endonuclease, family 2 AP3564_07055 ENOG4105D0M Protease HtpX homolog AP3564_07075 ENOG4105CJ1 ABC, transporter AP3564_07110 ENOG4105C26 Dehydrogenase AP3564_07115 ENOG4105DH8 myo-inositol catabolism AP3564_07120 ENOG4105D7K pfkb domain protein AP3564_07125 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AP3564_07130 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AP3564_07140 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AP3564_07145 ENOG4105C2J ABC transporter AP3564_07150 ENOG4105CNN ABC, transporter AP3564_07155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AP3564_07160 ENOG4105CK5 oxidoreductase AP3564_07165 ENOG4105D2N Aldolase AP3564_07175 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AP3564_07180 ENOG4105CQB FAD linked oxidase domain protein AP3564_07185 ENOG4105JXH GntR family transcriptional regulator AP3564_07205 ENOG4105FGM Fructosamine kinase AP3564_07215 ENOG4105C5A transporter AP3564_07220 ENOG4105E7W lamb ycsf family protein AP3564_07230 ENOG4105P4J Allophanate hydrolase, subunit 1 AP3564_07235 ENOG4107258 Transcriptional regulator AP3564_07260 ENOG4105CFM UPF0317 protein AP3564_07290 ENOG4105ETD TRANSCRIPTIONal AP3564_07315 ENOG4105DA5 (ABC) transporter AP3564_07330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AP3564_07340 ENOG4108594 Permease of the drug metabolite transporter AP3564_07345 ENOG4105CIH Imidazole acetol-phosphate transaminase AP3564_07360 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AP3564_07365 ENOG4105CVM Molybdenum cofactor synthesis domain protein AP3564_07375 ENOG4105DSE periplasmic solute binding protein AP3564_07380 ENOG4105DIK (ABC) transporter AP3564_07385 ENOG4105CC5 ABC transporter AP3564_07390 ENOG4105CC5 ABC transporter AP3564_07395 ENOG4105KST dependent repressor AP3564_07415 ENOG4105BZ4 penicillin-binding protein AP3564_07430 ENOG4105VFR signal peptidase AP3564_07465 ENOG410787A Pts system, glucitol sorbitol-specific AP3564_07470 ENOG4105DZY Pts system, glucitol sorbitol-specific AP3564_07475 ENOG4105VI0 Pts system, glucitol sorbitol-specific AP3564_07480 ENOG4107RHR regulatoR AP3564_07485 ENOG4107RUY (E1 component), alpha subunit AP3564_07490 ENOG4105CPP Dehydrogenase, E1 component AP3564_07495 ENOG4105C7S Dehydrogenase AP3564_07505 ENOG4107RHR regulatoR AP3564_07510 ENOG4108MRH transcriptional regulatory protein AP3564_07515 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AP3564_07520 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AP3564_07525 ENOG4107QJT sodium dicarboxylate symporter AP3564_07530 ENOG4105DG6 mannose-6-phosphate isomerase AP3564_07545 ENOG4108KGH TRANSCRIPTIONal AP3564_07555 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AP3564_07575 ENOG4105CKK Glycosyl transferase, family 2 AP3564_07585 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AP3564_07610 ENOG4105CJR Integral membrane protein (MviN AP3564_07615 ENOG4105ESV Glycosyl transferase, family 4 AP3564_07620 ENOG4105JNK Glycosyl transferase (Group 1 AP3564_07625 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AP3564_07630 ENOG4105ESV Glycosyl transferase, family 4 AP3564_07635 ENOG4108KGH TRANSCRIPTIONal AP3564_07640 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AP3564_07645 ENOG4105BZU Histidine kinase AP3564_07650 ENOG4105WH1 Two component transcriptional regulator luxr family AP3564_07670 ENOG41081UC Inherit from COG: Competence protein AP3564_07675 ENOG4105RU3 AP3564_07690 ENOG4105E1Q flagellar hook-associated protein AP3564_07695 ENOG4105DTJ flagellar hook-associated protein AP3564_07700 ENOG4105MKD AP3564_07705 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AP3564_07710 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AP3564_07715 ENOG4105I03 Flagellin AP3564_07735 ENOG4108IAJ Nad-dependent epimerase dehydratase AP3564_07740 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AP3564_07745 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase AP3564_07750 ENOG4105D2T synthase AP3564_07780 ENOG4105MZG transcriptional modulator of maze toxin, mazf AP3564_07815 ENOG41067SE Tetr family transcriptional regulator AP3564_07820 ENOG41069ER domain protein AP3564_07830 ENOG4106I4J membrane AP3564_07835 ENOG4108JUB Transcriptional regulator AP3564_07840 ENOG4105C0A alcohol dehydrogenase AP3564_07850 ENOG4105C26 Dehydrogenase AP3564_07855 ENOG4105D94 Major Facilitator Superfamily AP3564_07865 ENOG4105CID antiterminator AP3564_07870 ENOG4105CS2 ec 3.2.1.21 AP3564_07875 ENOG4105CS2 ec 3.2.1.21 AP3564_07880 ENOG4105C5Y PTS System AP3564_07885 ENOG4107Z6I Thiamine biosynthesis protein AP3564_07890 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AP3564_07900 ENOG4105EC8 Methyl-accepting chemotaxis AP3564_07910 ENOG4105EIG urea carboxylase-associated protein 1 AP3564_07915 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AP3564_07925 ENOG4105CNN ABC, transporter AP3564_07930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AP3564_07945 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AP3564_07955 ENOG4108JB8 alcohol dehydrogenase AP3564_07960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AP3564_07970 ENOG4107YHD transcriptional regulator AP3564_07975 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AP3564_07980 ENOG4105BZ8 glutamate synthase AP3564_07985 ENOG4107SJI Dehydrogenase AP3564_08005 ENOG4105EKQ RNA-directed DNA polymerase AP3564_08040 ENOG4108IUX (ABC) transporter AP3564_08045 ENOG4105RHA ABC transporter, permease AP3564_08050 ENOG4105C8Q Methyl-accepting chemotaxis AP3564_08060 ENOG4105E98 transcriptional regulator DeoR family AP3564_08065 ENOG4105NWF RbsD or FucU transport AP3564_08070 ENOG4105CMG Carbohydrate kinase AP3564_08075 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AP3564_08080 ENOG4105C2J ABC transporter AP3564_08105 ENOG4107W7X Aldolase AP3564_08110 ENOG4105DET Rhamnulokinase AP3564_08120 ENOG4105EF1 ribulokinase AP3564_08130 ENOG4108IIH CoA-transferase subunit B AP3564_08135 ENOG4105D6N CoA-transferase, subunit a AP3564_08140 ENOG4105CMU LysR family (Transcriptional regulator AP3564_08145 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AP3564_08150 ENOG4107TYC hydantoinase B oxoprolinase AP3564_08155 ENOG4105HKX acetone carboxylase, gamma subunit AP3564_08170 ENOG4105BZU Histidine kinase AP3564_08175 ENOG4105WH1 Two component transcriptional regulator luxr family AP3564_08180 ENOG4105CJ1 ABC, transporter AP3564_08195 ENOG4105BZ1 (ABC) transporter AP3564_08210 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase AP3564_08220 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AP3564_08225 ENOG4108UVJ appr-1-p processing domain protein AP3564_08230 ENOG4108VEN abc transporter atp-binding protein AP3564_08235 ENOG4108Z66 YbaK ebsC protein AP3564_08250 ENOG4105X1N Glycosyl transferase family 8 AP3564_08265 ENOG4105G9B Transcriptional regulator AP3564_08270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AP3564_08275 ENOG4105E39 Enoyl-CoA hydratase AP3564_08280 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_08290 ENOG4105C1G acyl-Coa dehydrogenase AP3564_08310 ENOG4105DZS Phenylacetate-CoA ligase AP3564_08325 ENOG4105ERH Fumarylacetoacetate hydrolase AP3564_08350 ENOG41083S7 flagellar protein FlaG AP3564_08355 ENOG4107RT6 flagellar hook-associated AP3564_08360 ENOG4105MQ3 flagellar protein FliS AP3564_08370 ENOG4105MS2 ribosomal subunit Interface protein AP3564_08375 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AP3564_08380 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AP3564_08390 ENOG4105CAK Cell division ATP-binding protein ftsE AP3564_08395 ENOG4105CRP Part of the ABC transporter FtsEX involved in AP3564_08400 ENOG4105DR5 peptidase AP3564_08405 ENOG4105CN1 protease AP3564_08415 ENOG4105H3G oxidoreductase AP3564_08420 ENOG4105PGM cation diffusion facilitator family transporter AP3564_08425 ENOG4105KTU Transcriptional regulator, arsr family AP3564_08450 ENOG4105D7V transposase AP3564_08455 ENOG4105EVU fructokinase AP3564_08465 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AP3564_08470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AP3564_08475 ENOG4105FDT acyl-CoA dehydrogenase AP3564_08485 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AP3564_08505 ENOG41086DT Membrane protein of unknown function AP3564_08510 ENOG41088CQ domain protein AP3564_08515 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AP3564_08525 ENOG4105HKU nucleoside recognition domain-containing protein AP3564_08530 ENOG4107XGZ Hydrolase AP3564_08535 ENOG4108S4C acetyltransferase AP3564_08540 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AP3564_08545 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AP3564_08550 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AP3564_08555 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AP3564_08560 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AP3564_08565 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AP3564_08570 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AP3564_08575 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AP3564_08585 ENOG4105C3M thioredoxin reductase AP3564_08590 ENOG4108Z4K mutator MutT protein AP3564_08595 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AP3564_08600 ENOG4105CHW UPF0052 protein AP3564_08605 ENOG4105CIE May be required for sporulation (By similarity) AP3564_08610 ENOG4105KRI phosphocarrier protein (HPr AP3564_08615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AP3564_08630 ENOG4105DY9 regulatoR AP3564_08635 ENOG4105CYC Transferase AP3564_08640 ENOG4105BZW Glycerate kinase AP3564_08650 ENOG4105F8D glycoside hydrolase family 4 AP3564_08680 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AP3564_08710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AP3564_08715 ENOG4105ETE Transcriptional regulator (LacI family AP3564_08720 ENOG41079KZ Major Facilitator Superfamily AP3564_08730 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AP3564_08740 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AP3564_08755 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_08775 ENOG4105BZA Phosphoglycerate kinase AP3564_08780 ENOG4105CP7 Triose-phosphate isomerase AP3564_08790 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AP3564_08800 ENOG4105XZU Preprotein translocase, subunit SecG AP3564_08810 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AP3564_08815 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AP3564_08830 ENOG4105CIY formyltetrahydrofolate deformylase AP3564_08835 ENOG4105V75 Transcriptional regulator AP3564_08840 ENOG4105C9Q fumarate hydratase class II AP3564_08850 ENOG4105CZN Potassium uptake protein AP3564_08855 ENOG4108MES Periplasmic binding protein AP3564_08860 ENOG4105DQ5 transport system permease protein AP3564_08865 ENOG4108IHU transport system permease protein AP3564_08870 ENOG4105E0A ABC, transporter AP3564_08900 ENOG4105CHU acetyl-coa acetyltransferase AP3564_08905 ENOG4105C1G acyl-Coa dehydrogenase AP3564_08910 ENOG41080E8 Transcriptional regulator, Spx MgsR family AP3564_08915 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AP3564_08935 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AP3564_08940 ENOG4108UMI ABC transporter, permease AP3564_08945 ENOG4105D01 (LipO)protein AP3564_08955 ENOG4105C3K feS assembly ATPase SufC AP3564_08960 ENOG4105JRK feS assembly protein SufD AP3564_08965 ENOG4105C9B Cysteine desulfurase AP3564_08970 ENOG4108UNV SUF system FeS assembly protein, NifU family AP3564_08975 ENOG4105DIW FeS assembly protein SUFB AP3564_08990 ENOG4105I3N Conserved Protein AP3564_08995 ENOG4107R8B 5'-nucleotidase AP3564_09000 ENOG4105KZD Domain of unknown function (DUF1805) AP3564_09005 ENOG4105FAA peptidase M23 AP3564_09010 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AP3564_09015 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AP3564_09020 ENOG4105MMD transcriptional regulator AP3564_09040 ENOG4105D4U had-superfamily hydrolase, subfamily iia AP3564_09045 ENOG4108W5N phosphatidylglycerophosphatase a AP3564_09055 ENOG4105C5I Dehydrogenase AP3564_09060 ENOG4105D6E homoserine dehydrogenase AP3564_09065 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AP3564_09070 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AP3564_09075 ENOG41083MR nifu domain-containing protein AP3564_09095 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AP3564_09100 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AP3564_09105 ENOG4105CAY ferredoxin--nadp reductase AP3564_09110 ENOG4105CEP NADH dehydrogenase AP3564_09120 ENOG41069ER domain protein AP3564_09125 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AP3564_09135 ENOG4105DCF alanine dehydrogenase AP3564_09165 ENOG4105C26 Dehydrogenase AP3564_09170 ENOG4105CY2 Citrate transporter AP3564_09205 ENOG4105BZU Histidine kinase AP3564_09215 ENOG4105KJM monovalent cation h antiporter subunit g AP3564_09225 ENOG4105SC1 monovalent cation H antiporter subunit E AP3564_09230 ENOG4108JPZ Monovalent cation H antiporter subunit D AP3564_09235 ENOG4108ZE9 Monovalent cation H antiporter subunit C AP3564_09240 ENOG4105HC0 Na H antiporter AP3564_09245 ENOG4105D65 subunit l AP3564_09255 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AP3564_09265 ENOG4105Y38 Kinase-associated protein B AP3564_09275 ENOG4105C87 Aminotransferase class I and II AP3564_09285 ENOG4108MUZ hydrolase AP3564_09290 ENOG4108ZB6 transcriptional regulator AsnC family AP3564_09295 ENOG4105CHM Aminotransferase AP3564_09305 ENOG4105WG9 Conserved Protein AP3564_09310 ENOG4107QYV phosphohexose isomerase AP3564_09320 ENOG4107PBV potassium channel AP3564_09325 ENOG4107PBV potassium channel AP3564_09335 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AP3564_09465 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AP3564_09470 ENOG4105E4F Isochorismate synthase AP3564_09475 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AP3564_09480 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AP3564_09485 ENOG4108IPT Naphthoate synthase AP3564_09490 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_09500 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AP3564_09505 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AP3564_09510 ENOG4108RMU ferritin dps family protein AP3564_09525 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AP3564_09535 ENOG4105D2X ABC transporter substrate-binding protein AP3564_09560 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AP3564_09565 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AP3564_09575 ENOG4108Z0R Transferase AP3564_09590 ENOG4105E8V Alpha Beta Hydrolase Fold protein AP3564_09605 ENOG4105N5T Radical SAM Protein AP3564_09615 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AP3564_09625 ENOG4105C8T Leucyl-tRNA synthetase AP3564_09630 ENOG41085GJ domain protein AP3564_09640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AP3564_09655 ENOG4105CBX hi0933 family AP3564_09670 ENOG4105YW5 deoR family transcriptional regulator AP3564_09680 ENOG4105C7N Xanthine uracil vitamin C permease AP3564_09685 ENOG4107QSE Dipeptidase AP3564_09690 ENOG41080TC multidrug resistance protein AP3564_09695 ENOG410839T multidrug resistance protein AP3564_09700 ENOG4105C6T cysteine synthase AP3564_09715 ENOG41067MG lrgb family AP3564_09725 ENOG4108V15 phosphotransferase enzyme family AP3564_09735 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AP3564_09765 ENOG4108NKM UPF0354 protein AP3564_09770 ENOG4108VDD TRNA binding domain protein AP3564_09780 ENOG4107QP3 malate synthase g AP3564_09795 ENOG4105XVF Competence transcription factor AP3564_09820 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AP3564_09825 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AP3564_09835 ENOG4105EYH Exonuclease AP3564_09870 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family AP3564_09880 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AP3564_09885 ENOG4108I5D sulfate abc transporter AP3564_09890 ENOG4105ECW sulfate abc transporter AP3564_09900 ENOG4105GVF (ABC) transporter AP3564_09915 ENOG4108RE7 deoxyribonuclease AP3564_09920 ENOG4105ERH Fumarylacetoacetate hydrolase AP3564_09935 ENOG4105CAQ asparagine synthetase AP3564_09955 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AP3564_09960 ENOG41088CQ domain protein AP3564_09985 ENOG4108VPT UPF0234 protein AP3564_09990 ENOG4105D7V transposase AP3564_10005 ENOG4105EPR degv family AP3564_10015 ENOG4108KP7 hydrolase AP3564_10020 ENOG4108MXZ Esterase AP3564_10025 ENOG4105VG1 fes assembly suf system protein AP3564_10030 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AP3564_10035 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AP3564_10050 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AP3564_10060 ENOG4105DBV ornithine carbamoyltransferase AP3564_10070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AP3564_10090 ENOG4107RMD Basic membrane lipoprotein AP3564_10100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AP3564_10105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AP3564_10125 ENOG4105C31 Tryptophanyl-tRNA synthetase AP3564_10130 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AP3564_10135 ENOG4108ZCF integral membrane protein AP3564_10140 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis AP3564_10145 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AP3564_10155 ENOG4105DPN Oligoendopeptidase f AP3564_10160 ENOG4105T58 Dithiol-disulfide isomerase AP3564_10165 ENOG4108Z18 K06886 hemoglobin AP3564_10170 ENOG4105E4C Lytic transglycosylase catalytic AP3564_10175 ENOG4105MIX Adenylate cyclase AP3564_10190 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AP3564_10195 ENOG4105EMS pseudouridine synthase AP3564_10200 ENOG4105CJW magnesium transporter AP3564_10210 ENOG4108VEU Thiamine monophosphate synthase AP3564_10225 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AP3564_10230 ENOG4105D06 uba thif-type nad fad binding protein AP3564_10235 ENOG4105DWF phosphomethylpyrimidine kinase AP3564_10240 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AP3564_10300 ENOG4105H67 Protein of unknown function (DUF421) AP3564_10310 ENOG4108ZMI UPF0477 protein AP3564_10330 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AP3564_10340 ENOG4105C28 cystathionine AP3564_10345 ENOG4105C28 cystathionine AP3564_10370 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AP3564_10380 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AP3564_10385 ENOG4107XVH Transcriptional regulator AP3564_10390 ENOG4105XRQ Xanthine dehydrogenase accessory factor AP3564_10420 ENOG4105E39 Enoyl-CoA hydratase AP3564_10425 ENOG4105CSH Transporter AP3564_10465 ENOG4105CAQ asparagine synthetase AP3564_10585 ENOG4105C5Y PTS System AP3564_10590 ENOG4105CG3 alpha amylase, catalytic region AP3564_10595 ENOG4107414 GntR family transcriptional regulator AP3564_10600 ENOG4105EKQ RNA-directed DNA polymerase AP3564_10645 ENOG4105BZU Histidine kinase AP3564_10650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_10680 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_10685 ENOG4107QIV Cytochrome c biogenesis protein AP3564_10690 ENOG4105VPX protein, conserved in bacteria AP3564_10695 ENOG4105C59 p-type ATPase AP3564_10710 ENOG4107R16 Multicopper oxidase AP3564_10725 ENOG4105E5H Transposase AP3564_10735 ENOG4105C5Y PTS System AP3564_10745 ENOG4105D7K pfkb domain protein AP3564_10750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AP3564_10755 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AP3564_10770 ENOG4105DHP deoxycytidine triphosphate deaminase AP3564_10775 ENOG4105CKI cobalamin synthesis protein AP3564_10790 ENOG4107R7Y intracellular protease Pfpi family AP3564_10800 ENOG4105CQB FAD linked oxidase domain protein AP3564_10805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AP3564_10810 ENOG4105XXY Thioredoxin AP3564_10850 ENOG4107SCJ type I restriction enzyme EcoKI subunit R AP3564_10865 ENOG4105E5H Transposase AP3564_10930 ENOG4105CQB FAD linked oxidase domain protein AP3564_10935 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AP3564_10940 ENOG4105D5U fad dependent oxidoreductase AP3564_10980 ENOG4105CVR type I restriction-modification system AP3564_11000 ENOG4108JJ9 ABC, transporter AP3564_11005 ENOG4108JJ8 (ABC) transporter AP3564_11025 ENOG4105CJ1 ABC, transporter AP3564_11040 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AP3564_11045 ENOG4108IEG Formate dehydrogenase Alpha subunit AP3564_11055 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AP3564_11075 ENOG4105CZM Major Facilitator AP3564_11100 ENOG41082UD thioesterase Superfamily protein AP3564_11105 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AP3564_11115 ENOG4105CAK Cell division ATP-binding protein ftsE AP3564_11135 ENOG4106YBV Methyl-accepting chemotaxis AP3564_11165 ENOG4107258 Transcriptional regulator AP3564_11170 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AP3564_11210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AP3564_11215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AP3564_11220 ENOG4105CHU acetyl-coa acetyltransferase AP3564_11225 ENOG4105C26 Dehydrogenase AP3564_11230 ENOG4105E39 Enoyl-CoA hydratase AP3564_11245 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AP3564_11255 ENOG4105VG1 fes assembly suf system protein AP3564_11270 ENOG4105E39 Enoyl-CoA hydratase AP3564_11275 ENOG4105E39 Enoyl-CoA hydratase AP3564_11290 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_11310 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AP3564_11315 ENOG4105DVE abc transporter atp-binding protein AP3564_11325 ENOG4105EMN RNA polymerase sigma factor AP3564_11335 ENOG4105F0I Aminotransferase AP3564_11350 ENOG4108SJC Membrane AP3564_11355 ENOG4107YZX Universal stress protein AP3564_11395 ENOG4108ZJ4 polysaccharide deacetylase AP3564_11405 ENOG4105C3M thioredoxin reductase AP3564_11410 ENOG4105F0V Cell wall hydrolase AP3564_11415 ENOG4105EKQ RNA-directed DNA polymerase AP3564_11435 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AP3564_11440 ENOG4105EHG Permease protein AP3564_11445 ENOG4105E0A ABC, transporter AP3564_11450 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AP3564_11455 ENOG4107QZB decarboxylase AP3564_11460 ENOG4108YZT Adenosylcobinamide kinase AP3564_11470 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AP3564_11500 ENOG4105C37 (CBS) domain AP3564_11505 ENOG4105EVH UPF0753 protein AP3564_11510 ENOG4108TWJ NADH dehydrogenase subunit 5 AP3564_11515 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AP3564_11520 ENOG4105CFH Aspartokinase AP3564_11525 ENOG4105C8Q Methyl-accepting chemotaxis AP3564_11535 ENOG4105BZU Histidine kinase AP3564_11545 ENOG4105DQE DNA ligase AP3564_11550 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AP3564_11555 ENOG4105FDF Could be involved in DNA repair (By similarity) AP3564_11560 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AP3564_11565 ENOG410681C small acid-soluble spore protein AP3564_11570 ENOG4108IJ7 Glycine betaine AP3564_11605 ENOG4107RVG penicillin-binding protein AP3564_11610 ENOG4107G43 radical SAM domain protein AP3564_11615 ENOG4105JXH GntR family transcriptional regulator AP3564_11620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AP3564_11625 ENOG4107QR9 Iron-sulfur cluster binding protein AP3564_11630 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AP3564_11635 ENOG4108TGC Acyltransferase AP3564_11640 ENOG4105BZU Histidine kinase AP3564_11645 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AP3564_11650 ENOG4105CDW Resistance protein AP3564_11660 ENOG4105K8R UPF0145 protein AP3564_11680 ENOG4105BZU Histidine kinase AP3564_11685 ENOG41090MY MarR family Transcriptional regulator AP3564_11695 ENOG4105ER2 Ompa motb domain protein AP3564_11700 ENOG4105E14 MotA TolQ exbB proton channel AP3564_11710 ENOG4108K88 Membrane AP3564_11715 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AP3564_11720 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AP3564_11725 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase AP3564_11730 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AP3564_11765 ENOG4108B31 Spore germination protein AP3564_11785 ENOG4105C59 p-type ATPase AP3564_11795 ENOG4107Y9E nuclease AP3564_11800 ENOG4105CTQ phosphohexokinase AP3564_11825 ENOG4105CID antiterminator AP3564_11835 ENOG4105KRI phosphocarrier protein (HPr AP3564_11840 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AP3564_11845 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AP3564_11850 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AP3564_11855 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AP3564_11860 ENOG4105K4I Scp-like extracellular AP3564_11870 ENOG4105BZU Histidine kinase AP3564_11875 ENOG4105CHM Aminotransferase AP3564_11880 ENOG4105D7N magnesium and cobalt transport protein CorA AP3564_11895 ENOG4107R88 Chemotaxis protein (CheV) AP3564_11900 ENOG4105UIN AP3564_11905 ENOG4105KTU Transcriptional regulator, arsr family AP3564_11930 ENOG4105EPM Diguanylate phosphodiesterase AP3564_11940 ENOG4105E0A ABC, transporter AP3564_11950 ENOG4108V5C ABC transporter AP3564_11955 ENOG4105DQ5 transport system permease protein AP3564_11960 ENOG4105EHG Permease protein AP3564_11975 ENOG4105C0R drug resistance transporter emrb qaca subfamily AP3564_11990 ENOG4105CH2 amidohydrolase AP3564_11995 ENOG4105D8X mechanosensitive ion channel AP3564_12000 ENOG4105D3R alkyl hydroperoxide reductase AP3564_12005 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_12020 ENOG4105ETU transcriptional activator (TenA AP3564_12025 ENOG4105ETU transcriptional activator (TenA AP3564_12035 ENOG4108JJB ABC transporter AP3564_12045 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AP3564_12050 ENOG4105C32 Amino acid ABC transporter (Permease) AP3564_12060 ENOG4105C0Z ABC transporter AP3564_12065 ENOG4108IV0 ABC, transporter AP3564_12070 ENOG4108YZ9 Urea amidohydrolase subunit gamma AP3564_12075 ENOG4105KI2 Urea amidohydrolase subunit beta AP3564_12085 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AP3564_12125 ENOG4105DKW ABC transporter AP3564_12130 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AP3564_12165 ENOG4105DZC cytosine deaminase AP3564_12170 ENOG4105CS1 NAD(P)H quinone oxidoreductase AP3564_12175 ENOG4105XRQ Xanthine dehydrogenase accessory factor AP3564_12190 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AP3564_12195 ENOG4107YV9 domain protein AP3564_12220 ENOG4105G9B Transcriptional regulator AP3564_12230 ENOG4105C5R Aminotransferase AP3564_12235 ENOG4105CD3 dihydroorotase AP3564_12250 ENOG4105EE0 oxidoreductase AP3564_12260 ENOG4105CFI type iii restriction protein res subunit AP3564_12335 ENOG4105E98 transcriptional regulator DeoR family AP3564_12340 ENOG4105DE4 1-phosphofructokinase AP3564_12345 ENOG4105DM4 PTS System AP3564_12355 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AP3564_12365 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AP3564_12370 ENOG4105CPN adenine deaminase AP3564_12375 ENOG4105FGV Chromate AP3564_12380 ENOG4105CAH Chromate AP3564_12400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AP3564_12420 ENOG4108IUX (ABC) transporter AP3564_12425 ENOG4105DVE abc transporter atp-binding protein AP3564_12430 ENOG4105FDP GntR family transcriptional regulator AP3564_12445 ENOG4105C7Z Conserved Protein AP3564_12460 ENOG4107V6Q Cyclic nucleotide-binding domain AP3564_12475 ENOG4107X8C Efflux transporter RND family MFP subunit AP3564_12480 ENOG4105C19 ABC transporter AP3564_12485 ENOG4107RBB ABC transporter, permease AP3564_12520 ENOG4105FDT acyl-CoA dehydrogenase AP3564_12525 ENOG4105EU0 Major facilitator Superfamily AP3564_12545 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AP3564_12555 ENOG4107ZYR domain protein AP3564_12560 ENOG4105CN5 Metallo-Beta-Lactamase AP3564_12565 ENOG4106148 UPF0356 protein AP3564_12570 ENOG4108X4Q Hydrolase AP3564_12575 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AP3564_12585 ENOG4105CPP Dehydrogenase, E1 component AP3564_12590 ENOG4105C7S Dehydrogenase AP3564_12610 ENOG4105VZ8 Transcriptional regulator AP3564_12635 ENOG4105CJ1 ABC, transporter AP3564_12665 ENOG4105SX7 Transporter AP3564_12670 ENOG4105CXN decarboxylase AP3564_12700 ENOG4105ECY inositol monophosphatase AP3564_12710 ENOG4105CI3 gtp-binding protein typa AP3564_12715 ENOG4105QA2 AP3564_12730 ENOG4108IAB Phoh family AP3564_12745 ENOG4105CNI cell division protein FtsW AP3564_12750 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AP3564_12765 ENOG410890F Dynamin family AP3564_12775 ENOG41081VK Ribonuclease AP3564_12795 ENOG4105CVG Homoserine O-transsuccinylase AP3564_12800 ENOG4108V06 Glutathione peroxidase AP3564_12810 ENOG4108Y6J UPF0403 protein AP3564_12825 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AP3564_12830 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AP3564_12835 ENOG4105C7B Threonine dehydratase AP3564_12845 ENOG4108RCR degv family AP3564_12850 ENOG4108KF3 Electron transport protein SCO1 SenC AP3564_12885 ENOG41090WU lipolytic protein G-D-S-L family AP3564_12890 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) AP3564_12895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AP3564_12910 ENOG4105E0X reductase AP3564_12920 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AP3564_12925 ENOG4105VSD UPF0346 protein AP3564_12940 ENOG4105G0J serine threonine protein kinase AP3564_12945 ENOG4108N23 SpoOM-related protein AP3564_12955 ENOG410841Q phosphoesterase PA-phosphatase related protein AP3564_12960 ENOG4106Z5R AP3564_12970 ENOG4108VXD carboxy-peptidase AP3564_12995 ENOG4105FR1 rard protein AP3564_13015 ENOG4105K4H Nlp p60 protein AP3564_13045 ENOG4108IQI permease AP3564_13050 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AP3564_13055 ENOG4107T89 von Willebrand factor, type A AP3564_13060 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AP3564_13065 ENOG4105C7S Dehydrogenase AP3564_13075 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AP3564_13080 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AP3564_13090 ENOG4105C26 Dehydrogenase AP3564_13110 ENOG4105WEF catalase AP3564_13120 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AP3564_13155 ENOG4108YTE sporulation protein YunB AP3564_13170 ENOG41090VF Stage v sporulation protein ac AP3564_13175 ENOG4105CZ3 stage V sporulation protein ad AP3564_13190 ENOG4108QY0 Membrane AP3564_13195 ENOG4105C3M thioredoxin reductase AP3564_13210 ENOG4105C01 Dihydroxy-acid dehydratase AP3564_13225 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AP3564_13245 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AP3564_13260 ENOG41079KZ Major Facilitator Superfamily AP3564_13265 ENOG41067SE Tetr family transcriptional regulator AP3564_13320 ENOG4105VPX protein, conserved in bacteria AP3564_13325 ENOG4105C59 p-type ATPase AP3564_13330 ENOG41082MP copper ion binding protein AP3564_13360 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AP3564_13385 ENOG4105CW7 secretion protein, HlyD family AP3564_13390 ENOG4105C0R drug resistance transporter emrb qaca subfamily AP3564_13400 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AP3564_13405 ENOG4108RPX mosc domain containing protein AP3564_13420 ENOG4105CR4 methylisocitrate lyase AP3564_13425 ENOG4105DXD 2-methylcitrate dehydratase AP3564_13445 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AP3564_13450 ENOG4105CPC Aldo Keto reductase AP3564_13460 ENOG4108HRK Histidine kinase AP3564_13465 ENOG4108NEV two component transcriptional regulator, LytTR family AP3564_13475 ENOG4105PF9 Transcriptional regulator AP3564_13485 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AP3564_13500 ENOG4105IIP Membrane AP3564_13505 ENOG4105W1N transcriptional regulator AP3564_13520 ENOG4107ZXU DSBA oxidoreductase AP3564_13535 ENOG4105EMN RNA polymerase sigma factor AP3564_13545 ENOG41067TZ transcriptional regulator, MarR family AP3564_13550 ENOG4105EYF MMPL domain protein AP3564_13555 ENOG4105VRS hydrolase family 18 AP3564_13570 ENOG4105VEQ Cold shock protein AP3564_13575 ENOG4105C9U ATP-dependent DNA helicase RecQ AP3564_13580 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AP3564_13615 ENOG410667J hydrolase AP3564_13625 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AP3564_13630 ENOG4105ECK Fatty Acid Desaturase AP3564_13635 ENOG4108ZGX Histidine kinase AP3564_13640 ENOG4108S01 response regulator AP3564_13650 ENOG4107TPS domain protein AP3564_13685 ENOG4105CG3 alpha amylase, catalytic region AP3564_13690 ENOG41080XP Cbs domain AP3564_13700 ENOG4105EMU Dehydrogenase AP3564_13705 ENOG4105BZU Histidine kinase AP3564_13710 ENOG4105WH1 Two component transcriptional regulator luxr family AP3564_13715 ENOG4107R6D beta-lactam binding protein AmpH AP3564_13730 ENOG4105VCD cytoplasmic protein AP3564_13740 ENOG41080HI glycine oxidase AP3564_13750 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AP3564_13795 ENOG4105CAQ asparagine synthetase AP3564_13800 ENOG4105UQX Mate efflux family protein AP3564_13805 ENOG4106HBX Transcriptional Regulator AraC Family AP3564_13815 ENOG4107FKK extracellular solute-binding protein family 1 AP3564_13825 ENOG4105EG2 ABC transporter, permease AP3564_13830 ENOG4108IUK alpha amylase, catalytic AP3564_13840 ENOG4105ETE Transcriptional regulator (LacI family AP3564_13880 ENOG4105XTG Pfam:DUF156 AP3564_13885 ENOG4105VFE sira family AP3564_13890 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AP3564_13920 ENOG4107QIV Cytochrome c biogenesis protein AP3564_13925 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_13930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_13935 ENOG4105EB3 Histidine kinase AP3564_13940 ENOG4105VRS hydrolase family 18 AP3564_13945 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AP3564_13955 ENOG4107TPS domain protein AP3564_13960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AP3564_13970 ENOG4105XTG Pfam:DUF156 AP3564_13975 ENOG4105VFE sira family AP3564_13980 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AP3564_13990 ENOG41085GJ domain protein AP3564_13995 ENOG4105VFE sira family AP3564_14000 ENOG4107TPS domain protein AP3564_14005 ENOG41084XP SirA-like domain-containing protein AP3564_14010 ENOG41087NI Sulfite exporter TauE/SafE AP3564_14035 ENOG4105DUM transcriptional regulator, lysR family AP3564_14050 ENOG4105C59 p-type ATPase AP3564_14090 ENOG4105WAB arsR family transcriptional regulator AP3564_14095 ENOG4108EKI Dehydrogenase AP3564_14125 ENOG4105EWC Purine nucleoside phosphorylase AP3564_14135 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) AP3564_14145 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AP3564_14150 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AP3564_14155 ENOG4108JUB Transcriptional regulator AP3564_14165 ENOG4105C0A alcohol dehydrogenase AP3564_14185 ENOG4105VMP Transcriptional regulator AP3564_14210 ENOG4105C09 Bile acid AP3564_14225 ENOG4105C5H ABC transporter AP3564_14230 ENOG4105DHI Methyltransferase AP3564_14240 ENOG4105U5Y Transcriptional regulator AP3564_14245 ENOG4105C1G acyl-Coa dehydrogenase AP3564_14250 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_14255 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AP3564_14260 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AP3564_14265 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AP3564_14270 ENOG4105E39 Enoyl-CoA hydratase AP3564_14275 ENOG4107QX3 carboxylase AP3564_14280 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AP3564_14285 ENOG4105E0C molybdate abc transporter AP3564_14290 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AP3564_14295 ENOG4105EKQ RNA-directed DNA polymerase AP3564_14300 ENOG4108R96 Methyltransferase, YaeB family AP3564_14305 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AP3564_14315 ENOG4105E1F short-chain dehydrogenase reductase AP3564_14320 ENOG4108HFV AP3564_14330 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AP3564_14340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AP3564_14345 ENOG4108UMI ABC transporter, permease AP3564_14350 ENOG41082YX Transcriptional regulator, arsr family AP3564_14355 ENOG4105D6J arsenicaL-resistance protein AP3564_14360 ENOG4108UXE Protein tyrosine phosphatase AP3564_14370 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AP3564_14375 ENOG4107EPV Aminotransferase class V AP3564_14380 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AP3564_14385 ENOG41089UC methyltransferase, type 11 AP3564_14420 ENOG4105E5H Transposase AP3564_14435 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AP3564_14510 ENOG4105DA5 (ABC) transporter AP3564_14515 ENOG4105DQ4 alcohol dehydrogenase AP3564_14520 ENOG4105ST3 Transcriptional regulator AP3564_14525 ENOG4105E1F short-chain dehydrogenase reductase AP3564_14530 ENOG4105CF7 AraC family transcriptional regulator AP3564_14590 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AP3564_14605 ENOG4108ZAF Molybdopterin AP3564_14610 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AP3564_14615 ENOG4105CVM Molybdenum cofactor synthesis domain protein AP3564_14620 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AP3564_14625 ENOG4105EPU Molybdenum cofactor synthesis domain protein AP3564_14655 ENOG4105VG1 fes assembly suf system protein AP3564_14665 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AP3564_14670 ENOG4107V6Q Cyclic nucleotide-binding domain AP3564_14685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AP3564_14700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AP3564_14705 ENOG4105K4P CoA-binding domain protein AP3564_14710 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AP3564_14715 ENOG4105DVT helicase AP3564_14735 ENOG4105W8X HesB YadR YfhF-family protein AP3564_14740 ENOG4105MI2 AP3564_14755 ENOG41075ZD Small, acid-soluble spore protein N AP3564_14760 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_14765 ENOG4108I0Z Aconitate hydratase AP3564_14795 ENOG4107YTP response regulator receiver protein AP3564_14800 ENOG4107QIV Cytochrome c biogenesis protein AP3564_14805 ENOG4105VXM UPF0154 protein AP3564_14820 ENOG4105VPS UPF0291 protein AP3564_14825 ENOG4108SVB resolvase AP3564_14835 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AP3564_14840 ENOG4105D82 Glutamate dehydrogenase AP3564_14845 ENOG4105F6E Acyl-transferase AP3564_14850 ENOG4108URH decarboxylase AP3564_14855 ENOG4107SET aldo keto reductase AP3564_14860 ENOG4105FBA Phospholipase Carboxylesterase AP3564_14865 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AP3564_14900 ENOG4105ENE Histidine kinase AP3564_14905 ENOG4105WH1 Two component transcriptional regulator luxr family AP3564_14915 ENOG4105C8Q Methyl-accepting chemotaxis AP3564_14925 ENOG4105BZU Histidine kinase AP3564_14955 ENOG4108KK1 membrane protein AbrB duplication AP3564_14960 ENOG4108KAM Transcriptional regulator AP3564_14980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_14985 ENOG4105BZU Histidine kinase AP3564_14995 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AP3564_15025 ENOG4105C19 ABC transporter AP3564_15065 ENOG4105E1F short-chain dehydrogenase reductase AP3564_15085 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AP3564_15175 ENOG4107QJZ Glycosyl transferase, family 2 AP3564_15185 ENOG4105BZU Histidine kinase AP3564_15190 ENOG4107R88 Chemotaxis protein (CheV) AP3564_15195 ENOG4105D7V transposase AP3564_15300 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AP3564_15310 ENOG4108KPW sugar kinase AP3564_15335 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AP3564_15340 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AP3564_15345 ENOG4105XN3 extracellular solute-binding protein family 1 AP3564_15355 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AP3564_15360 ENOG4105FDP GntR family transcriptional regulator AP3564_15370 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AP3564_15395 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AP3564_15475 ENOG4105DQ6 Transposase AP3564_15530 ENOG4105C6Z Gluconate AP3564_15535 ENOG4105CMG Carbohydrate kinase AP3564_15545 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AP3564_15550 ENOG4108V4M Cobalt abc transporter AP3564_15585 ENOG4108V9W transcriptional regulatory protein AP3564_15590 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AP3564_15615 ENOG4105CPU Monooxygenase AP3564_15630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AP3564_15640 ENOG4107QSA Oxaloacetate decarboxylase AP3564_15645 ENOG4105DZS Phenylacetate-CoA ligase AP3564_15650 ENOG4107258 Transcriptional regulator AP3564_15655 ENOG4107HP6 Transcriptional regulator AP3564_15765 ENOG4105C5F glutamine synthetase AP3564_15770 ENOG4105KV4 Transcriptional regulator AP3564_15775 ENOG4105CXI aluminum resistance protein AP3564_15780 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AP3564_15785 ENOG4106F1P AAA ATPase, central domain protein AP3564_15790 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AP3564_15795 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AP3564_15800 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AP3564_15805 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AP3564_15820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AP3564_15825 ENOG4105DQU oxidoreductase, subunit beta AP3564_15830 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AP3564_15835 ENOG4105MCT stage V sporulation protein S AP3564_15840 ENOG4105D48 metallophosphoesterase AP3564_15845 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AP3564_15850 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AP3564_15855 ENOG4105CEV competence damage-inducible protein AP3564_15860 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AP3564_15875 ENOG4105XZV Protein of unknown function (DUF3243) AP3564_15880 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AP3564_15905 ENOG4105CNU cell division protein FtsK AP3564_15915 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AP3564_15925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AP3564_15935 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AP3564_15940 ENOG4108S0H Dipicolinic acid synthetase, b subunit AP3564_15945 ENOG4105E35 Dipicolinate synthase subunit A AP3564_15955 ENOG4105C1V Peptidase, M16 AP3564_15965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AP3564_15970 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AP3564_15975 ENOG4105DTN riboflavin biosynthesis protein ribF AP3564_15980 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AP3564_15990 ENOG4105W7A Protein of unknown function (DUF503) AP3564_15995 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AP3564_16000 ENOG4105VHM ribosomal protein AP3564_16005 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AP3564_16010 ENOG4105CHV Transcription elongation factor NusA AP3564_16015 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AP3564_16020 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AP3564_16025 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AP3564_16030 ENOG4105DZP Membrane-associated zinc metalloprotease AP3564_16040 ENOG4105KNE Phosphatidate cytidylyltransferase AP3564_16045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AP3564_16050 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AP3564_16055 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AP3564_16060 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AP3564_16065 ENOG4105CE9 30S ribosomal protein S2 AP3564_16075 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_16080 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AP3564_16090 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AP3564_16095 ENOG4105CBS Chea signal transduction histidine kinase AP3564_16100 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AP3564_16110 ENOG4105FZW flagellar biosynthesis regulator FlhF AP3564_16115 ENOG4105D7B Flagellar biosynthesis protein flha AP3564_16120 ENOG4105D00 flagellar biosynthetic protein flhB AP3564_16125 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AP3564_16130 ENOG4105VS8 Flagellar biosynthetic protein fliq AP3564_16135 ENOG4105CN7 Flagellar biosynthetic protein FliP AP3564_16145 ENOG4107YTP response regulator receiver protein AP3564_16150 ENOG4105DD5 Flagellar motor switch protein AP3564_16155 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AP3564_16165 ENOG41068WV flagellar FlbD family protein AP3564_16170 ENOG4108JQA flagellar AP3564_16175 ENOG410822I Flagellar hook capping protein AP3564_16180 ENOG410696Y Flagellar hook-length control protein AP3564_16190 ENOG4106YF4 Flagellar biosynthesis chaperone AP3564_16205 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AP3564_16210 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AP3564_16215 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AP3564_16220 ENOG4108ZC9 flagellar basal-body rod protein flgc AP3564_16225 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AP3564_16230 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) AP3564_16235 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AP3564_16240 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AP3564_16245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AP3564_16250 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AP3564_16255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AP3564_16260 ENOG4105C79 DNA protecting protein DprA AP3564_16265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AP3564_16270 ENOG4105CMV Succinyl-CoA synthetase subunit beta AP3564_16275 ENOG4105VM1 flagellar AP3564_16285 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AP3564_16300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AP3564_16310 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AP3564_16325 ENOG4105VB6 UPF0109 protein AP3564_16330 ENOG4105K5M 30s ribosomal protein S16 AP3564_16340 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AP3564_16345 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AP3564_16350 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AP3564_16355 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AP3564_16360 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AP3564_16365 ENOG4105CHR reductase AP3564_16370 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AP3564_16375 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AP3564_16380 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AP3564_16385 ENOG4105CB5 ATP-dependent DNA helicase recG AP3564_16390 ENOG4105DP4 dak2 domain fusion protein ylov AP3564_16395 ENOG4108ZAA Alkaline-shock protein AP3564_16400 ENOG4105VB9 50S ribosomal protein l28 AP3564_16410 ENOG4105DJV ribulose-phosphate 3-epimerase AP3564_16415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AP3564_16420 ENOG4105D9P serine threonine protein kinase AP3564_16425 ENOG4108ZF3 Phosphatase AP3564_16430 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AP3564_16435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AP3564_16440 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AP3564_16445 ENOG4105C25 Primosomal protein n' AP3564_16450 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AP3564_16460 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AP3564_16465 ENOG4105KC4 UPF0296 protein AP3564_16470 ENOG4105DSJ YicC domain protein AP3564_16480 ENOG4105F23 Fibronectin-binding protein AP3564_16485 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AP3564_16490 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AP3564_16500 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AP3564_16505 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AP3564_16510 ENOG4107RIQ Sulfate adenylate transferase AP3564_16515 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AP3564_16520 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AP3564_16525 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AP3564_16530 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AP3564_16535 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AP3564_16540 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AP3564_16555 ENOG4105CXT aspartate transcarbamylase AP3564_16565 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AP3564_16570 ENOG4105C34 Pseudouridine synthase AP3564_16575 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AP3564_16585 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AP3564_16595 ENOG4105DBK s4 domain protein AP3564_16600 ENOG41067XK integral membrane protein AP3564_16605 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AP3564_16610 ENOG4105DFA alanine racemase domain protein AP3564_16615 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AP3564_16620 ENOG4105WR5 sporulation protein, YlmC YmxH family AP3564_16630 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_16635 ENOG4105FFI sigma-e processing peptidase spoiiga AP3564_16640 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AP3564_16645 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AP3564_16650 ENOG4105K67 small basic protein AP3564_16660 ENOG4108R2U division initiation protein AP3564_16665 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AP3564_16670 ENOG4105D4A Cell wall formation (By similarity) AP3564_16675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AP3564_16680 ENOG4105CNI cell division protein FtsW AP3564_16685 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AP3564_16690 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AP3564_16695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AP3564_16700 ENOG4105CJN penicillin-binding protein AP3564_16705 ENOG4105CJN penicillin-binding protein AP3564_16715 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AP3564_16720 ENOG4108V6E Cell division protein mraZ AP3564_16725 ENOG41074B2 UPF0747 protein AP3564_16755 ENOG41067VY 50S ribosomal protein L32 AP3564_16760 ENOG4105KNH Nucleic acid-binding protein AP3564_16765 ENOG4105CDE UPF0348 protein AP3564_16770 ENOG41063PX domain protein AP3564_16775 ENOG4105D78 K07001 NTE family protein AP3564_16780 ENOG4105H20 Sporulation integral membrane protein YlbJ AP3564_16785 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AP3564_16790 ENOG4106H78 methyltransferase AP3564_16805 ENOG4105WUC UPF0298 protein AP3564_16835 ENOG4106UY4 Inherit from COG: Scp-like extracellular AP3564_16855 ENOG41064X9 cytochrome C oxidase subunit IV AP3564_16860 ENOG4105CCU oxidase (Subunit III) AP3564_16865 ENOG4105BZ9 Cytochrome C oxidase, subunit I AP3564_16875 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AP3564_16880 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AP3564_16885 ENOG4105CTD carboxy-peptidase AP3564_16890 ENOG4105DVT helicase AP3564_16895 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AP3564_16915 ENOG4107X2U Inherit from COG: Exonuclease-like protein AP3564_16920 ENOG4108I5C dEAD DEAH box helicase AP3564_16955 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AP3564_16960 ENOG4105BZ4 penicillin-binding protein AP3564_16970 ENOG4105CSM endonuclease III AP3564_16980 ENOG4105C5S asparaginyl-tRNA synthetase AP3564_16985 ENOG4105CHM Aminotransferase AP3564_16995 ENOG4105YAC AP3564_17005 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AP3564_17010 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AP3564_17015 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AP3564_17025 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AP3564_17030 ENOG4105CPK Glycosyl transferase (Group 1 AP3564_17035 ENOG4108Z5K methylglyoxal synthase AP3564_17040 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AP3564_17045 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AP3564_17050 ENOG4108JYZ YitT family AP3564_17075 ENOG4105BZG amino acid carrier protein AP3564_17085 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AP3564_17090 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AP3564_17110 ENOG4108SXZ UPF0302 protein AP3564_17115 ENOG41068YB TPR repeat-containing protein AP3564_17125 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AP3564_17135 ENOG4105CIH Imidazole acetol-phosphate transaminase AP3564_17140 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AP3564_17150 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AP3564_17155 ENOG4105DK0 Indole-3-glycerol phosphate synthase AP3564_17160 ENOG4108I0Q anthranilate phosphoribosyltransferase AP3564_17170 ENOG4105KHN chorismate mutase AP3564_17175 ENOG4105D49 3-dehydroquinate synthase AP3564_17180 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AP3564_17185 ENOG4105BZU Histidine kinase AP3564_17190 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AP3564_17195 ENOG4105EAH synthase AP3564_17200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AP3564_17205 ENOG4105XXQ heptaprenyl diphosphate synthase component I AP3564_17210 ENOG4105WP2 Tryptophan RNA-binding attenuator protein AP3564_17215 ENOG4105EUJ GTP cyclohydrolase i AP3564_17220 ENOG4105K70 DNA-binding protein AP3564_17235 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AP3564_17250 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AP3564_17255 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AP3564_17260 ENOG41065D1 AP3564_17265 ENOG4105S2F AP3564_17275 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AP3564_17280 ENOG4105F6E Acyl-transferase AP3564_17285 ENOG4105CAT Cytidine monophosphate kinase AP3564_17295 ENOG4105MSI germination protein ypeb AP3564_17305 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AP3564_17310 ENOG4105HDK L-asparaginase AP3564_17315 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AP3564_17340 ENOG4105I7S Abortive infection protein AP3564_17345 ENOG4105C9U ATP-dependent DNA helicase RecQ AP3564_17350 ENOG4105T7X AP3564_17360 ENOG4108SAX Membrane AP3564_17370 ENOG4108JQ1 Dehydrogenase AP3564_17385 ENOG4108WBT adenosyltransferase AP3564_17390 ENOG4105BZU Histidine kinase AP3564_17395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AP3564_17400 ENOG4105CRE cytochrome C AP3564_17405 ENOG4107TWT Cytochrome c biogenesis protein AP3564_17410 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AP3564_17415 ENOG4105FE9 pseudouridine synthase AP3564_17425 ENOG4108JIC nucleoside recognition domain protein AP3564_17430 ENOG4105DZ1 carboxypeptidase AP3564_17435 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AP3564_17440 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AP3564_17455 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AP3564_17460 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AP3564_17465 ENOG4108R6K riboflavin synthase, subunit alpha AP3564_17480 ENOG4107ZE5 PPIases accelerate the folding of proteins AP3564_17485 ENOG4105PTM secreted protein AP3564_17490 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AP3564_17500 ENOG4105CZ3 stage V sporulation protein ad AP3564_17515 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_17520 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AP3564_17525 ENOG41082AN stage II sporulation protein AP3564_17530 ENOG4105DZ1 carboxypeptidase AP3564_17550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AP3564_17560 ENOG4105I3K Ferric uptake regulator, Fur family AP3564_17565 ENOG4105MZ9 stage II sporulation protein m AP3564_17575 ENOG4108YZ4 nudix hydrolase AP3564_17585 ENOG4105CPC Aldo Keto reductase AP3564_17615 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AP3564_17620 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AP3564_17635 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AP3564_17645 ENOG4108IXY short-chain dehydrogenase reductase AP3564_17650 ENOG41069FQ Metallo-beta-lactamase superfamily AP3564_17655 ENOG4105II7 pyrroline-5-carboxylate reductase AP3564_17660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AP3564_17670 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AP3564_17675 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AP3564_17680 ENOG410855V Acylphosphatase AP3564_17685 ENOG4108HWW ABC transporter AP3564_17700 ENOG4105EWU Squalene--hopene cyclase AP3564_17720 ENOG4105C2J ABC transporter AP3564_17735 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AP3564_17740 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AP3564_17745 ENOG4105BZ8 glutamate synthase AP3564_17750 ENOG4105CBC glutamate synthase AP3564_17755 ENOG4105C5Q Transcriptional regulator AP3564_17760 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AP3564_17765 ENOG4108QEG Membrane AP3564_17770 ENOG4108Y6J UPF0403 protein AP3564_17775 ENOG4105C7S Dehydrogenase AP3564_17780 ENOG4105CPP Dehydrogenase, E1 component AP3564_17795 ENOG4106CCJ Protein of unknown function (DUF2627) AP3564_17800 ENOG4107QQR Sporulation AP3564_17805 ENOG4105S1Z Stage IV sporulation protein B AP3564_17810 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AP3564_17815 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AP3564_17820 ENOG4105DX0 Hemolysin A AP3564_17825 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AP3564_17835 ENOG4105CTB Polyprenyl synthetase AP3564_17840 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AP3564_17845 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AP3564_17850 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AP3564_17855 ENOG4105M7K Involved in the transcription termination process (By similarity) AP3564_17860 ENOG4108ZSR alkaline shock protein AP3564_17865 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AP3564_17885 ENOG410644B Stage III sporulation protein af AP3564_17895 ENOG4105KQ4 Stage iii sporulation protein ad AP3564_17900 ENOG4108CQH stage III sporulation protein AC AP3564_17905 ENOG4105KR5 Stage iii sporulation protein AP3564_17910 ENOG4105CD2 stage iii sporulation protein aa AP3564_17915 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AP3564_17920 ENOG4105DC7 peptidase M24 AP3564_17925 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AP3564_17935 ENOG4105CBJ Metal-dependent enzyme AP3564_17965 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein AP3564_18005 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AP3564_18010 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AP3564_18015 ENOG4105WZW rhodanese family AP3564_18020 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AP3564_18025 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AP3564_18030 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AP3564_18035 ENOG4105C0D helicase AP3564_18070 ENOG4106855 Competence protein AP3564_18100 ENOG4105C5X domain protein AP3564_18120 ENOG4105E0M Sulfatase AP3564_18135 ENOG4107ZXI Rhomboid family AP3564_18145 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AP3564_18150 ENOG4105WDJ 50S ribosomal protein L33 AP3564_18160 ENOG41068DG YceG-like family AP3564_18165 ENOG4108UTW Plays a role in the regulation of phosphate uptake AP3564_18170 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AP3564_18175 ENOG4105E2Z phosphate ABC transporter (Permease AP3564_18180 ENOG4105C8U phosphate abc transporter AP3564_18185 ENOG4105EXS phosphate abc transporter AP3564_18205 ENOG4105SXS Protein of unknown function (DUF456) AP3564_18220 ENOG4105C8Q Methyl-accepting chemotaxis AP3564_18235 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AP3564_18245 ENOG41063Y9 AP3564_18250 ENOG4105N80 Ferric uptake regulator, Fur family AP3564_18255 ENOG4105FAV ABC, transporter AP3564_18260 ENOG4105FDK ABC transporter AP3564_18265 ENOG4108JYZ YitT family AP3564_18270 ENOG41069ZM Protein of unknown function (DUF2624) AP3564_18275 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AP3564_18290 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AP3564_18295 ENOG4105EGD dinuclear metal center protein, YbgI family AP3564_18310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_18315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AP3564_18320 ENOG4107XJU UPF0178 protein AP3564_18325 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AP3564_18335 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AP3564_18340 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AP3564_18345 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) AP3564_18355 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AP3564_18360 ENOG4105KG3 cytidine deaminase AP3564_18365 ENOG4107YR5 Diacylglycerol kinase AP3564_18370 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AP3564_18375 ENOG4105CTJ Metal Dependent Phosphohydrolase AP3564_18380 ENOG4105C9A Phoh family AP3564_18390 ENOG41068P3 sporulation protein YqfC AP3564_18400 ENOG4105DI5 UPF0365 protein AP3564_18405 ENOG4105F7J membrane-bound serine protease AP3564_18410 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AP3564_18425 ENOG4105KTH gatB Yqey AP3564_18430 ENOG4105VCC 30S ribosomal protein S21 AP3564_18440 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AP3564_18445 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AP3564_18450 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AP3564_18455 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AP3564_18460 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AP3564_18465 ENOG4105CFG Acts as a chaperone (By similarity) AP3564_18470 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AP3564_18475 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AP3564_18480 ENOG4105CSA Coproporphyrinogen iii oxidase AP3564_18485 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AP3564_18495 ENOG4108ZRV stage ii sporulation protein p AP3564_18505 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AP3564_18510 ENOG4105TQK DNA polymerase iii, delta' subunit AP3564_18520 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AP3564_18525 ENOG4108UK2 deaminase AP3564_18530 ENOG4105KQC Competence protein AP3564_18540 ENOG4108D32 Methyltransferase AP3564_18550 ENOG4108WF2 Metal Dependent Phosphohydrolase AP3564_18555 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AP3564_18560 ENOG410812S Rna-binding protein AP3564_18570 ENOG4105CQW ribosome biogenesis GTPase YqeH AP3564_18575 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AP3564_18585 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AP3564_18595 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AP3564_18605 ENOG4107XRG penicillin-binding protein AP3564_18610 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AP3564_18615 ENOG4105CFP Peptidase U32 AP3564_18620 ENOG4105XYU peptidase (U32 family) AP3564_18625 ENOG4108VQJ O-methyltransferase AP3564_18630 ENOG4105HHA aminodeoxychorismate lyase AP3564_18635 ENOG4105VPH UPF0473 protein AP3564_18640 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AP3564_18645 ENOG4105VBH UPF0297 protein AP3564_18650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AP3564_18655 ENOG4105C02 permease AP3564_18660 ENOG41060CR AP3564_18665 ENOG4105C7H Helicase, RecD TraA family AP3564_18675 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AP3564_18680 ENOG4105C3J Cysteine desulfurase AP3564_18690 ENOG4105D1H recombination factor protein RarA AP3564_18695 ENOG4105CUZ uba thif-type nad fad binding protein AP3564_18705 ENOG4105C9M aspartyl-trna synthetase AP3564_18710 ENOG4105CUT histidyl-tRNA synthetase AP3564_18715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AP3564_18720 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AP3564_18725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AP3564_18730 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AP3564_18735 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AP3564_18740 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AP3564_18750 ENOG4105CKP Polysaccharide Biosynthesis Protein AP3564_18755 ENOG4105NAP AP3564_18760 ENOG4105VIE preprotein translocase, subunit YajC AP3564_18765 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AP3564_18770 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AP3564_18775 ENOG41061AI Protein of unknown function (DUF2905) AP3564_18780 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AP3564_18785 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AP3564_18795 ENOG4105CDY transcriptional regulatory protein AP3564_18805 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AP3564_18810 ENOG4105EKQ RNA-directed DNA polymerase AP3564_18815 ENOG4106678 morphogenetic protein associated with SpoVID AP3564_18820 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AP3564_18825 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AP3564_18835 ENOG4108IYU L-aspartate oxidase AP3564_18850 ENOG4105CQC Prephenate dehydratase AP3564_18855 ENOG41090I5 UPF0735 ACT domain-containing protein AP3564_18860 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AP3564_18870 ENOG4105K46 50S ribosomal protein l27 AP3564_18875 ENOG4105X36 (ribosomal) protein AP3564_18880 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AP3564_18885 ENOG4105C03 ribonuclease AP3564_18900 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AP3564_18905 ENOG4107Y03 Nitroreductase AP3564_18915 ENOG4107QMS site-determining protein AP3564_18920 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AP3564_18925 ENOG4105YHC Rod shape-determining protein MreD AP3564_18930 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AP3564_18935 ENOG4105DFF Rod shape-determining protein mreb AP3564_18940 ENOG4105W5Q DNA repair protein (RadC AP3564_18945 ENOG4108Z03 MAF-like protein AP3564_18955 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AP3564_18975 ENOG41068KH stage VI sporulation protein D AP3564_18980 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AP3564_18985 ENOG4105D52 delta-aminolevulinic acid dehydratase AP3564_18995 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AP3564_19005 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AP3564_19015 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AP3564_19020 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AP3564_19025 ENOG4108IUQ atp-dependent protease AP3564_19030 ENOG4105EKQ RNA-directed DNA polymerase AP3564_19035 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AP3564_19040 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AP3564_19050 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AP3564_19055 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AP3564_19060 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AP3564_19065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AP3564_19070 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AP3564_19075 ENOG4108ZP8 Acetolactate synthase small subunit AP3564_19080 ENOG4105C7K acetolactate synthase AP3564_19085 ENOG4105UNS Pfam:DUF419 AP3564_19095 ENOG4105M59 Phosphodiesterase, mj0936 family AP3564_19100 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AP3564_19105 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AP3564_19110 ENOG4108XJQ germination protein AP3564_19115 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AP3564_19120 ENOG41067TZ transcriptional regulator, MarR family AP3564_19125 ENOG4105PFC Transcriptional regulator AP3564_19130 ENOG4105E33 succinate dehydrogenase AP3564_19140 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AP3564_19150 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AP3564_19155 ENOG4105K63 Thioredoxin AP3564_19160 ENOG4105C10 Electron transfer flavoprotein AP3564_19165 ENOG4105BZJ Electron transfer flavoprotein AP3564_19170 ENOG4107Z3H Transcriptional regulator, TetR family AP3564_19175 ENOG4105CEY Amp-dependent synthetase and ligase AP3564_19185 ENOG4105C98 muts2 protein AP3564_19205 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AP3564_19210 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AP3564_19215 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AP3564_19220 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AP3564_19230 ENOG4108RWN rrna methyltransferase AP3564_19240 ENOG4105CN9 Peptidase m42 family protein AP3564_19255 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AP3564_19260 ENOG4105VJV 50s ribosomal protein L35 AP3564_19270 ENOG4106GRI small acid-soluble spore protein H AP3564_19275 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AP3564_19280 ENOG4105EKQ RNA-directed DNA polymerase AP3564_19285 ENOG4105C22 threonyL-tRNA synthetase AP3564_19290 ENOG4108TDW sporulation protein YtxC AP3564_19305 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AP3564_19310 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AP3564_19315 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AP3564_19330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AP3564_19335 ENOG4105C2M dna polymerase I AP3564_19340 ENOG4105EPW hflc protein AP3564_19345 ENOG4107QJR hflk protein AP3564_19350 ENOG4105BZU Histidine kinase AP3564_19355 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AP3564_19365 ENOG4108HMX isocitrate dehydrogenase (NADP) AP3564_19370 ENOG4105BZN citrate synthase AP3564_19375 ENOG4105FS0 cytoplasmic membrane protein AP3564_19380 ENOG4105CA9 Pyruvate kinase AP3564_19385 ENOG4105CTQ phosphohexokinase AP3564_19390 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AP3564_19395 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AP3564_19400 ENOG4105C6K Malic enzyme AP3564_19405 ENOG4105C0B DNA polymerase III (alpha subunit) AP3564_19410 ENOG4105VV2 AP3564_19420 ENOG4105SFS phosphoesterase RecJ domain protein AP3564_19435 ENOG4105E8R UPF0173 metal-dependent hydrolase AP3564_19445 ENOG4105CH7 arginosuccinase AP3564_19450 ENOG4105CDH Citrulline--aspartate ligase AP3564_19470 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AP3564_19480 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AP3564_19485 ENOG4105KBJ sporulation protein ytfj AP3564_19495 ENOG4105VK3 rdd domain containing protein AP3564_19500 ENOG4105D07 Signal peptide peptidase, SppA AP3564_19505 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AP3564_19515 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AP3564_19525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AP3564_19530 ENOG4105CV8 reductase AP3564_19545 ENOG4105U5Y Transcriptional regulator AP3564_19555 ENOG4105BZU Histidine kinase AP3564_19560 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AP3564_19635 ENOG41061GT Aldolase AP3564_19640 ENOG4105CPQ Dehydrogenase AP3564_19650 ENOG4106KNT transcriptional regulator