locus-tag	class	description
AP3564_00170	COG0606	chelatase, subunit chli
AP3564_00205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_00215	COG2153	protein acetylation
AP3564_00235	COG0438	transferase activity, transferring glycosyl groups
AP3564_00240	COG2144	transferase activity, transferring acyl groups
AP3564_00250	COG0431	NADPH-dependent FMN reductase
AP3564_00280	COG0559	Belongs to the binding-protein-dependent transport system permease family
AP3564_00290	COG0411	ABC transporter
AP3564_00305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_00310	COG2030	dehydratase
AP3564_00315	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_00335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_00345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AP3564_00350	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_00370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AP3564_00375	COG1595	DNA-templated transcription, initiation
AP3564_00385	COG1131	(ABC) transporter
AP3564_00435	COG0745	RESPONSE REGULATOR receiver
AP3564_00440	COG5002	protein histidine kinase activity
AP3564_00455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_00455	COG3711	transcriptional antiterminator
AP3564_00465	COG3730	PTS system glucitol sorbitol-specific
AP3564_00470	COG3732	PTS system glucitol sorbitol-specific
AP3564_00480	COG0386	Belongs to the glutathione peroxidase family
AP3564_00485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_00490	COG2356	endonuclease I
AP3564_00505	COG2213	PTS system mannitol-specific
AP3564_00505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_00510	COG3414	Phosphotransferase system galactitol-specific IIB component
AP3564_00515	COG3775	system Galactitol-specific IIC component
AP3564_00520	COG1063	alcohol dehydrogenase
AP3564_00530	COG1063	alcohol dehydrogenase
AP3564_00550	COG0477	Major facilitator Superfamily
AP3564_00565	COG0583	DNA-binding transcription factor activity
AP3564_00580	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_00590	COG0196	riboflavin kinase activity
AP3564_00595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP3564_00600	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_00615	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_00625	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_00645	COG0559	Belongs to the binding-protein-dependent transport system permease family
AP3564_00655	COG0411	ABC transporter
AP3564_00660	COG0410	ABC transporter
AP3564_00700	COG0714	Associated with various cellular activities
AP3564_00705	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AP3564_00710	COG1305	Transglutaminase-like
AP3564_00715	COG0519	Catalyzes the synthesis of GMP from XMP
AP3564_00715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AP3564_00720	COG2252	PERMEase
AP3564_00725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AP3564_00730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AP3564_00735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AP3564_00740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AP3564_00745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP3564_00750	COG0047	phosphoribosylformylglycinamidine synthase activity
AP3564_00755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP3564_00760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AP3564_00765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AP3564_00770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AP3564_00775	COG0138	bifunctional purine biosynthesis protein purh
AP3564_00790	COG0151	Belongs to the GarS family
AP3564_00795	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_00800	COG1470	cell adhesion involved in biofilm formation
AP3564_00805	COG4496	protein, YerC YecD
AP3564_00810	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AP3564_00815	COG0210	DNA helicase
AP3564_00825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AP3564_00830	COG4851	CamS sex pheromone cAM373 precursor
AP3564_00845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AP3564_00850	COG0154	amidase activity
AP3564_00860	COG1597	lipid kinase activity
AP3564_00865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP3564_00895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_00925	COG4372	Transposase
AP3564_00945	COG1201	RNA secondary structure unwinding
AP3564_00955	COG1192	Involved in chromosome partitioning
AP3564_00980	COG1192	Involved in chromosome partitioning
AP3564_01030	COG2031	fatty acid transporter
AP3564_01035	COG0583	DNA-binding transcription factor activity
AP3564_01040	COG0477	Major facilitator Superfamily
AP3564_01055	COG1309	transcriptional regulator
AP3564_01060	COG1131	(ABC) transporter
AP3564_01095	COG0579	oxidoreductase
AP3564_01100	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_01105	COG0686	Belongs to the AlaDH PNT family
AP3564_01110	COG2508	Transcriptional regulator
AP3564_01110	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AP3564_01115	COG1126	abc transporter atp-binding protein
AP3564_01120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_01145	COG1126	abc transporter atp-binding protein
AP3564_01165	COG1309	transcriptional regulator
AP3564_01200	COG1518	maintenance of DNA repeat elements
AP3564_01205	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AP3564_01210	COG0840	transmembrane signaling receptor activity
AP3564_01220	COG0582	viral genome integration into host DNA
AP3564_01225	COG0490	domain, Protein
AP3564_01230	COG0475	glutathione-regulated potassium exporter activity
AP3564_01235	COG1473	amidohydrolase
AP3564_01245	COG2814	Major facilitator Superfamily
AP3564_01250	COG1309	transcriptional regulator
AP3564_01255	COG2966	Psort location CytoplasmicMembrane, score
AP3564_01280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AP3564_01295	COG3842	ATPase activity
AP3564_01300	COG1176	ABC-type spermidine putrescine transport system, permease component I
AP3564_01305	COG1177	transmembrane transport
AP3564_01310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP3564_01320	COG2814	Major facilitator Superfamily
AP3564_01325	COG0753	catalase activity
AP3564_01330	COG1132	(ABC) transporter
AP3564_01340	COG0561	phosphatase activity
AP3564_01345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AP3564_01350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_01355	COG4605	iron ion homeostasis
AP3564_01360	COG4604	ABC transporter, ATP-binding protein
AP3564_01365	COG4607	ABC-type enterochelin transport system periplasmic component
AP3564_01390	COG1587	Uroporphyrinogen-III synthase
AP3564_01405	COG3842	ATPase activity
AP3564_01410	COG0395	ABC-type sugar transport system, permease component
AP3564_01415	COG1175	transmembrane transport
AP3564_01420	COG1653	transport
AP3564_01425	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AP3564_01430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_01445	COG1733	regulation of RNA biosynthetic process
AP3564_01460	COG1960	acyl-CoA dehydrogenase activity
AP3564_01480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_01485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_01490	COG4948	Mandelate Racemase Muconate Lactonizing
AP3564_01500	COG2311	Membrane
AP3564_01520	COG4840	Belongs to the UPF0435 family
AP3564_01525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_01530	COG4980	gas vesicle protein
AP3564_01535	COG1295	ribonuclease BN
AP3564_01560	COG1511	domain protein
AP3564_01565	COG1309	transcriptional regulator
AP3564_01585	COG0387	Pfam Sodium calcium exchanger
AP3564_01595	COG0535	radical SAM domain protein
AP3564_01620	COG1850	ribulose-bisphosphate carboxylase activity
AP3564_01625	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AP3564_01630	COG0235	Class ii aldolase
AP3564_01635	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AP3564_01640	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AP3564_01645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AP3564_01650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_01655	COG0436	Aminotransferase
AP3564_01670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AP3564_01675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP3564_01680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AP3564_01705	COG2801	Transposase and inactivated derivatives
AP3564_01780	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_01855	COG1404	Belongs to the peptidase S8 family
AP3564_01890	COG2190	(PTS) system
AP3564_01895	COG1737	Transcriptional regulator
AP3564_01900	COG1486	melibiose metabolic process
AP3564_01905	COG1263	PTS System
AP3564_01905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_02000	COG2721	sulfolactate sulfo-lyase activity
AP3564_02020	COG2186	Transcriptional regulator
AP3564_02035	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_02045	COG1309	transcriptional regulator
AP3564_02050	COG1694	Mazg nucleotide pyrophosphohydrolase
AP3564_02065	COG1116	anion transmembrane transporter activity
AP3564_02070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_02105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP3564_02110	COG1063	alcohol dehydrogenase
AP3564_02140	COG1742	UPF0060 membrane protein
AP3564_02145	COG0501	Belongs to the peptidase M48B family
AP3564_02150	COG2814	Major facilitator Superfamily
AP3564_02170	COG0789	Transcriptional regulator
AP3564_02180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AP3564_02200	COG0626	cystathionine gamma-synthase activity
AP3564_02205	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_02210	COG0385	Bile acid
AP3564_02245	COG0583	DNA-binding transcription factor activity
AP3564_02250	COG2814	Major facilitator Superfamily
AP3564_02255	COG2066	Belongs to the glutaminase family
AP3564_02265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_02270	COG2271	Major facilitator Superfamily
AP3564_02275	COG0028	Belongs to the TPP enzyme family
AP3564_02280	COG0583	DNA-binding transcription factor activity
AP3564_02285	COG0861	Integral membrane protein TerC family
AP3564_02315	COG2137	regulation of response to DNA damage stimulus
AP3564_02330	COG1988	membrane-bound metal-dependent
AP3564_02335	COG1194	a g-specific adenine glycosylase
AP3564_02345	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_02355	COG1968	undecaprenyl-diphosphatase activity
AP3564_02365	COG3557	Belongs to the UPF0374 family
AP3564_02370	COG1132	(ABC) transporter
AP3564_02380	COG4129	membrane
AP3564_02385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP3564_02390	COG4555	ABC transporter
AP3564_02410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP3564_02415	COG0735	belongs to the Fur family
AP3564_02520	COG4974	Belongs to the 'phage' integrase family
AP3564_02550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AP3564_02555	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AP3564_02560	COG3290	protein histidine kinase activity
AP3564_02560	COG3829	transcription factor binding
AP3564_02565	COG2376	Dihydroxyacetone kinase
AP3564_02580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_02590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AP3564_02595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AP3564_02620	COG1959	2 iron, 2 sulfur cluster binding
AP3564_02625	COG0482	sulfurtransferase activity
AP3564_02630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_02635	COG0702	epimerase
AP3564_02650	COG2837	iron assimilation
AP3564_02655	COG2822	iron ion transport
AP3564_02660	COG3284	Transcriptional regulator
AP3564_02665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_02670	COG0022	dehydrogenase e1 component
AP3564_02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_02695	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_02710	COG1063	alcohol dehydrogenase
AP3564_02715	COG2814	Major facilitator Superfamily
AP3564_02730	COG0431	NADPH-dependent FMN reductase
AP3564_02735	COG2226	methyltransferase
AP3564_02760	COG3382	B3 4 domain protein
AP3564_02785	COG2766	serine protein kinase
AP3564_02790	COG2718	Belongs to the UPF0229 family
AP3564_02795	COG0706	membrane insertase activity
AP3564_02805	COG1268	BioY protein
AP3564_02810	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_02815	COG0183	Belongs to the thiolase family
AP3564_02820	COG0586	Pfam SNARE associated Golgi protein
AP3564_02830	COG2249	NAD(P)H dehydrogenase (quinone) activity
AP3564_02835	COG0656	L-ascorbic acid biosynthetic process
AP3564_02850	COG0517	IMP dehydrogenase activity
AP3564_02855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP3564_02865	COG1959	2 iron, 2 sulfur cluster binding
AP3564_02875	COG2719	SpoVR family
AP3564_02880	COG0861	Integral membrane protein TerC family
AP3564_02900	COG0628	permease
AP3564_02915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AP3564_02925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_02930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_02955	COG0411	ABC transporter
AP3564_02970	COG0840	transmembrane signaling receptor activity
AP3564_02995	COG0189	ligase activity
AP3564_03000	COG0189	ligase activity
AP3564_03005	COG0189	ligase activity
AP3564_03015	COG4399	Belongs to the UPF0754 family
AP3564_03020	COG0697	spore germination
AP3564_03040	COG3679	Belongs to the UPF0342 family
AP3564_03045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP3564_03050	COG1940	carbohydrate kinase activity
AP3564_03055	COG0561	phosphatase activity
AP3564_03060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP3564_03075	COG0420	3'-5' exonuclease activity
AP3564_03080	COG4717	serine-type aminopeptidase activity
AP3564_03085	COG3481	metal-dependent phosphohydrolase, HD sub domain
AP3564_03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP3564_03115	COG1846	Transcriptional regulator
AP3564_03120	COG4980	gas vesicle protein
AP3564_03135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AP3564_03140	COG0537	adenosine 5'-monophosphoramidase activity
AP3564_03145	COG4473	ABC transporter
AP3564_03150	COG1131	(ABC) transporter
AP3564_03155	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_03160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_03165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AP3564_03180	COG1609	Transcriptional regulator
AP3564_03190	COG1234	tRNA 3'-trailer cleavage
AP3564_03200	COG4120	Belongs to the binding-protein-dependent transport system permease family
AP3564_03205	COG1116	anion transmembrane transporter activity
AP3564_03205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_03210	COG1396	sequence-specific DNA binding
AP3564_03215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AP3564_03225	COG0501	Belongs to the peptidase M48B family
AP3564_03230	COG1674	ftsk spoiiie
AP3564_03235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AP3564_03240	COG2309	aminopeptidase activity
AP3564_03245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AP3564_03260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AP3564_03260	COG1605	Chorismate mutase
AP3564_03265	COG1609	Transcriptional regulator
AP3564_03270	COG0123	including yeast histone deacetylase and acetoin utilization protein
AP3564_03275	COG0517	IMP dehydrogenase activity
AP3564_03280	COG0454	-acetyltransferase
AP3564_03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AP3564_03290	COG0456	acetyltransferase
AP3564_03305	COG3209	COG3209 Rhs family protein
AP3564_03515	COG1737	Transcriptional regulator
AP3564_03525	COG1063	alcohol dehydrogenase
AP3564_03530	COG1830	Aldolase
AP3564_03555	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AP3564_03560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_03600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP3564_03605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AP3564_03610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_03620	COG1063	alcohol dehydrogenase
AP3564_03625	COG1830	Aldolase
AP3564_03640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_03650	COG1091	dTDP-4-dehydrorhamnose reductase activity
AP3564_03675	COG1216	Glycosyl transferase, family 2
AP3564_03675	COG0463	Glycosyl transferase, family 2
AP3564_03715	COG1064	alcohol dehydrogenase
AP3564_03730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AP3564_03735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AP3564_03740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AP3564_03745	COG4464	protein tyrosine phosphatase activity
AP3564_03750	COG0489	protein tyrosine kinase activity
AP3564_03755	COG3944	biosynthesis protein
AP3564_03760	COG4715	Zinc finger, swim domain protein
AP3564_03765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP3564_03770	COG0629	single-stranded DNA binding
AP3564_03780	COG1476	TRANSCRIPTIONal
AP3564_03805	COG4786	Flagellar basal body rod
AP3564_03810	COG4786	Flagellar basal body rod
AP3564_03815	COG1077	Cell shape determining protein MreB Mrl
AP3564_03820	COG1609	Transcriptional regulator
AP3564_03830	COG1984	allophanate hydrolase subunit 2
AP3564_03835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_03840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_03845	COG1247	-acetyltransferase
AP3564_03850	COG0739	heme binding
AP3564_03860	COG2385	sporulation resulting in formation of a cellular spore
AP3564_03865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP3564_03875	COG4836	Membrane
AP3564_03880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AP3564_03885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AP3564_03890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AP3564_03895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AP3564_03900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP3564_03905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AP3564_03910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP3564_03915	COG0356	it plays a direct role in the translocation of protons across the membrane
AP3564_03930	COG1404	Belongs to the peptidase S8 family
AP3564_03940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AP3564_03945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AP3564_03955	COG0698	ribose 5-phosphate isomerase
AP3564_03960	COG0840	transmembrane signaling receptor activity
AP3564_03965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_03970	COG1971	Probably functions as a manganese efflux pump
AP3564_03975	COG0009	L-threonylcarbamoyladenylate synthase
AP3564_03990	COG2890	protein-(glutamine-N5) methyltransferase activity
AP3564_03995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AP3564_04000	COG0789	Transcriptional regulator
AP3564_04010	COG1435	thymidine kinase activity
AP3564_04015	COG0254	rRNA binding
AP3564_04020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AP3564_04025	COG1494	fructose-1,6-bisphosphatase
AP3564_04030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP3564_04035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP3564_04040	COG0191	fructose-bisphosphate aldolase activity
AP3564_04045	COG2204	response regulator
AP3564_04050	COG4821	SIS domain
AP3564_04055	COG0504	CTP synthase activity
AP3564_04060	COG3343	RNA polymerase activity
AP3564_04065	COG2181	nitrate reductase activity
AP3564_04065	COG0247	lactate metabolic process
AP3564_04070	COG1595	DNA-templated transcription, initiation
AP3564_04075	COG0018	arginyl-trna synthetase
AP3564_04080	COG4506	Protein conserved in bacteria
AP3564_04085	COG0010	Belongs to the arginase family
AP3564_04090	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AP3564_04095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_04115	COG4844	belongs to the
AP3564_04120	COG1078	dGTPase activity
AP3564_04125	COG3465	dGTPase activity
AP3564_04130	COG1994	Peptidase M50
AP3564_04140	COG0280	phosphate acetyltransferase
AP3564_04150	COG3773	Cell wall hydrolase
AP3564_04160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AP3564_04165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AP3564_04170	COG2363	Small membrane protein
AP3564_04220	COG0351	phosphomethylpyrimidine kinase
AP3564_04225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AP3564_04230	COG0584	glycerophosphoryl diester phosphodiesterase
AP3564_04240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_04245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AP3564_04260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AP3564_04265	COG0778	Nitroreductase
AP3564_04270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP3564_04280	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AP3564_04290	COG0765	amino acid transport
AP3564_04305	COG0561	phosphatase activity
AP3564_04310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP3564_04330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP3564_04340	COG0410	ABC transporter
AP3564_04345	COG0411	ABC transporter
AP3564_04360	COG0683	leucine binding
AP3564_04370	COG3764	Sortase (surface protein transpeptidase)
AP3564_04380	COG0022	dehydrogenase e1 component
AP3564_04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_04430	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AP3564_04435	COG0737	Belongs to the 5'-nucleotidase family
AP3564_04450	COG0456	acetyltransferase
AP3564_04455	COG3153	acetyltransferase
AP3564_04455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_04460	COG0745	RESPONSE REGULATOR receiver
AP3564_04465	COG2205	protein histidine kinase activity
AP3564_04470	COG1136	(ABC) transporter
AP3564_04475	COG0577	efflux transmembrane transporter activity
AP3564_04480	COG2910	NAD(P)H-binding
AP3564_04485	COG1959	2 iron, 2 sulfur cluster binding
AP3564_04490	COG0784	Response regulator, receiver
AP3564_04495	COG4191	Histidine kinase
AP3564_04515	COG1131	(ABC) transporter
AP3564_04520	COG2072	flavoprotein involved in K transport
AP3564_04530	COG1607	acyl-coa hydrolase
AP3564_04540	COG0583	DNA-binding transcription factor activity
AP3564_04570	COG3973	AAA domain
AP3564_04575	COG0039	L-malate dehydrogenase activity
AP3564_04585	COG5002	protein histidine kinase activity
AP3564_04605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP3564_04610	COG0732	type I restriction modification DNA specificity domain
AP3564_04615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_04630	COG1349	DNA-binding transcription factor activity
AP3564_04640	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP3564_04640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_04655	COG3192	ethanolamine utilization protein
AP3564_04665	COG1349	DNA-binding transcription factor activity
AP3564_04685	COG1403	HNH endonuclease
AP3564_04700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AP3564_04710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_04715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AP3564_04720	COG4853	Protein conserved in bacteria
AP3564_04730	COG5002	protein histidine kinase activity
AP3564_04735	COG0745	RESPONSE REGULATOR receiver
AP3564_04750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AP3564_04755	COG0305	Participates in initiation and elongation during chromosome replication
AP3564_04760	COG0359	binds to the 23S rRNA
AP3564_04765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AP3564_04770	COG4241	membrane
AP3564_04775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AP3564_04780	COG0629	single-stranded DNA binding
AP3564_04785	COG0360	Binds together with S18 to 16S ribosomal RNA
AP3564_04790	COG0012	GTP binding
AP3564_04795	COG4481	Protein conserved in bacteria
AP3564_04805	COG1475	DNA binding
AP3564_04810	COG1192	Involved in chromosome partitioning
AP3564_04820	COG1475	DNA binding
AP3564_04825	COG0357	Ribosomal RNA small subunit methyltransferase G
AP3564_04830	COG0445	tRNA wobble uridine modification
AP3564_04835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AP3564_04840	COG1847	R3H domain protein
AP3564_04845	COG0706	membrane insertase activity
AP3564_04850	COG0594	ribonuclease P activity
AP3564_04855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AP3564_04865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AP3564_04870	COG0592	DNA-directed DNA polymerase activity
AP3564_04875	COG2501	S4 domain
AP3564_04880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP3564_04885	COG0187	DNA topoisomerase II activity
AP3564_04890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP3564_04930	COG0517	IMP dehydrogenase activity
AP3564_04930	COG0516	GMP reductase activity
AP3564_04950	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AP3564_04955	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AP3564_04960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AP3564_04965	COG0579	oxidoreductase
AP3564_04985	COG3858	chitin binding
AP3564_04985	COG1388	LysM domain
AP3564_04990	COG0590	tRNA wobble adenosine to inosine editing
AP3564_05000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AP3564_05005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AP3564_05010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AP3564_05045	COG1982	Orn Lys Arg decarboxylase major
AP3564_05050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AP3564_05055	COG3870	Protein conserved in bacteria
AP3564_05060	COG1728	Protein conserved in bacteria
AP3564_05065	COG0470	DNA polymerase III
AP3564_05070	COG1774	PSP1 C-terminal conserved region
AP3564_05075	COG4467	Involved in initiation control of chromosome replication
AP3564_05080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AP3564_05085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AP3564_05090	COG2002	toxin-antitoxin pair type II binding
AP3564_05100	COG0084	hydrolase, TatD family'
AP3564_05105	COG3583	domain protein
AP3564_05105	COG3584	3D domain protein
AP3564_05110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AP3564_05115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AP3564_05125	COG4466	Protein conserved in bacteria
AP3564_05135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AP3564_05140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP3564_05145	COG0251	oxidation-reduction process
AP3564_05150	COG2088	sporulation resulting in formation of a cellular spore
AP3564_05155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AP3564_05160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AP3564_05165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AP3564_05170	COG0193	aminoacyl-tRNA hydrolase activity
AP3564_05180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AP3564_05185	COG2002	toxin-antitoxin pair type II binding
AP3564_05210	COG2244	polysaccharide biosynthetic process
AP3564_05215	COG3956	TIGRFAM MazG family protein
AP3564_05220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AP3564_05235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AP3564_05240	COG1098	S1 RNA binding domain
AP3564_05255	COG2208	phosphoserine phosphatase activity
AP3564_05260	COG2304	oxidoreductase activity
AP3564_05265	COG0515	serine threonine protein kinase
AP3564_05270	COG0037	tRNA processing
AP3564_05280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP3564_05285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AP3564_05290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AP3564_05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP3564_05300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP3564_05305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP3564_05310	COG0512	Glutamine amidotransferase of anthranilate synthase
AP3564_05315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP3564_05320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AP3564_05325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AP3564_05330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AP3564_05335	COG1396	sequence-specific DNA binding
AP3564_05340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP3564_05345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AP3564_05450	COG1131	(ABC) transporter
AP3564_05470	COG4372	Transposase
AP3564_05505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AP3564_05540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP3564_05565	COG1285	pathogenesis
AP3564_05570	COG4463	regulation of RNA biosynthetic process
AP3564_05575	COG3880	PFAM UvrB UvrC protein
AP3564_05580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AP3564_05585	COG0542	response to heat
AP3564_05590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AP3564_05595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AP3564_05600	COG4956	integral membrane protein (PIN domain superfamily)
AP3564_05605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AP3564_05610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AP3564_05615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP3564_05620	COG1045	serine acetyltransferase
AP3564_05625	COG0215	cysteine-tRNA ligase activity
AP3564_05630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AP3564_05635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_05640	COG3688	RNA-binding protein containing a PIN domain
AP3564_05650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP3564_05655	COG0250	Participates in transcription elongation, termination and antitermination
AP3564_05665	COG0081	regulation of translation
AP3564_05670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AP3564_05675	COG0222	ribosome binding
AP3564_05680	COG2813	Specifically methylates the guanine in position
AP3564_05685	COG0085	RNA polymerase activity
AP3564_05690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AP3564_05695	COG1358	cellular component organization or biogenesis
AP3564_05700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AP3564_05705	COG0049	tRNA binding
AP3564_05710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AP3564_05715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AP3564_05720	COG0051	transcription antitermination factor activity, RNA binding
AP3564_05725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AP3564_05730	COG0088	Forms part of the polypeptide exit tunnel
AP3564_05735	COG0089	rRNA binding
AP3564_05740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AP3564_05745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AP3564_05750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AP3564_05755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AP3564_05760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AP3564_05765	COG0255	Belongs to the universal ribosomal protein uL29 family
AP3564_05770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AP3564_05775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AP3564_05780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AP3564_05785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AP3564_05790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AP3564_05795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AP3564_05800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AP3564_05805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AP3564_05810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AP3564_05820	COG0200	Binds to the 23S rRNA
AP3564_05825	COG0201	protein transport
AP3564_05830	COG0563	adenylate kinase activity
AP3564_05835	COG0024	Methionine aminopeptidase
AP3564_05840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
AP3564_05845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AP3564_05850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AP3564_05855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AP3564_05860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AP3564_05870	COG0203	ribosomal protein L17
AP3564_05875	COG1122	ATPase activity
AP3564_05880	COG1122	ATPase activity
AP3564_05885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AP3564_05890	COG0101	tRNA pseudouridine synthase activity
AP3564_05895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AP3564_05900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AP3564_05935	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_05940	COG0489	protein tyrosine kinase activity
AP3564_05950	COG2194	sulfuric ester hydrolase activity
AP3564_05960	COG0726	polysaccharide deacetylase
AP3564_06040	COG0789	Transcriptional regulator
AP3564_06045	COG1595	DNA-templated transcription, initiation
AP3564_06050	COG5662	AntiSigma factor
AP3564_06055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AP3564_06060	COG4856	YbbR-like protein
AP3564_06065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP3564_06070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP3564_06080	COG0789	Transcriptional regulator
AP3564_06085	COG1253	flavin adenine dinucleotide binding
AP3564_06110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_06115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_06115	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP3564_06135	COG1609	Transcriptional regulator
AP3564_06140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_06150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AP3564_06155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AP3564_06160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_06170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP3564_06175	COG1063	alcohol dehydrogenase
AP3564_06180	COG0800	Aldolase
AP3564_06185	COG1312	Catalyzes the dehydration of D-mannonate
AP3564_06190	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_06235	COG1113	amino acid transport
AP3564_06245	COG0583	DNA-binding transcription factor activity
AP3564_06250	COG2070	2-Nitropropane dioxygenase
AP3564_06265	COG0277	FAD linked oxidase domain protein
AP3564_06270	COG0247	lactate metabolic process
AP3564_06275	COG0277	FAD linked oxidase domain protein
AP3564_06280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AP3564_06290	COG1414	Transcriptional regulator
AP3564_06295	COG1620	l-lactate permease
AP3564_06300	COG1937	Protein conserved in bacteria
AP3564_06305	COG0534	Mate efflux family protein
AP3564_06315	COG0765	amino acid transport
AP3564_06320	COG1126	abc transporter atp-binding protein
AP3564_06340	COG2076	Multidrug Resistance protein
AP3564_06345	COG2076	Multidrug Resistance protein
AP3564_06355	COG4806	L-rhamnose isomerase
AP3564_06360	COG1070	Carbohydrate kinase
AP3564_06375	COG2972	Histidine kinase
AP3564_06380	COG2207	Transcriptional regulator
AP3564_06385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP3564_06390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_06395	COG1129	ABC transporter
AP3564_06400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_06410	COG1879	ABC-type sugar transport system periplasmic component
AP3564_06415	COG1070	Carbohydrate kinase
AP3564_06430	COG1413	lyase activity
AP3564_06440	COG1131	(ABC) transporter
AP3564_06445	COG1266	CAAX protease self-immunity
AP3564_06450	COG0535	radical SAM domain protein
AP3564_06460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_06465	COG2814	Major facilitator Superfamily
AP3564_06475	COG3832	glyoxalase III activity
AP3564_06490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP3564_06510	COG1472	Belongs to the glycosyl hydrolase 3 family
AP3564_06525	COG1114	Component of the transport system for branched-chain amino acids
AP3564_06540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_06545	COG2078	PFAM AMMECR1 domain protein
AP3564_06545	COG3885	ferrous iron binding
AP3564_06560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_06590	COG0483	inositol monophosphate 1-phosphatase activity
AP3564_06595	COG2186	Transcriptional regulator
AP3564_06600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AP3564_06615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_06635	COG0693	protein deglycase activity
AP3564_06645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_06650	COG0702	epimerase
AP3564_06655	COG2807	transmembrane transport
AP3564_06675	COG2807	transmembrane transport
AP3564_06685	COG1175	transmembrane transport
AP3564_06690	COG0395	ABC-type sugar transport system, permease component
AP3564_06695	COG1653	transport
AP3564_06700	COG0584	glycerophosphoryl diester phosphodiesterase
AP3564_06705	COG0745	RESPONSE REGULATOR receiver
AP3564_06710	COG3850	Histidine kinase
AP3564_06710	COG5002	protein histidine kinase activity
AP3564_06715	COG2514	catechol 2,3-dioxygenase activity
AP3564_06730	COG0069	glutamate synthase activity
AP3564_06735	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AP3564_06740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP3564_06750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_06755	COG1181	Belongs to the D-alanine--D-alanine ligase family
AP3564_06760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AP3564_06765	COG0513	Belongs to the DEAD box helicase family
AP3564_06770	COG3402	PFAM membrane-flanked domain
AP3564_06775	COG3428	Bacterial PH domain
AP3564_06780	COG0705	Rhomboid family
AP3564_06785	COG0736	holo-[acyl-carrier-protein] synthase activity
AP3564_06790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AP3564_06800	COG0864	Transcriptional regulator
AP3564_06805	COG2337	Toxic component of a toxin-antitoxin (TA) module
AP3564_06815	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_06820	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_06825	COG2172	sigma factor antagonist activity
AP3564_06830	COG2208	phosphoserine phosphatase activity
AP3564_06835	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_06845	COG1191	sigma factor activity
AP3564_06850	COG2208	phosphoserine phosphatase activity
AP3564_06855	COG2183	response to ionizing radiation
AP3564_06860	COG3091	SprT-like family
AP3564_06940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AP3564_06945	COG0802	atpase or kinase
AP3564_06950	COG1214	PFAM Peptidase M22, glycoprotease
AP3564_06955	COG0456	acetyltransferase
AP3564_06960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AP3564_06965	COG0488	(ABC) transporter
AP3564_06970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AP3564_06975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP3564_06980	COG0805	protein transport
AP3564_06990	COG1266	CAAX protease self-immunity
AP3564_06995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP3564_07000	COG0459	protein refolding
AP3564_07005	COG3739	integral membrane protein
AP3564_07055	COG0501	Belongs to the peptidase M48B family
AP3564_07075	COG1131	(ABC) transporter
AP3564_07105	COG1349	DNA-binding transcription factor activity
AP3564_07110	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_07115	COG3718	enzyme involved in inositol metabolism
AP3564_07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_07125	COG3962	Belongs to the TPP enzyme family
AP3564_07130	COG1082	Xylose isomerase domain protein TIM barrel
AP3564_07140	COG0673	inositol 2-dehydrogenase activity
AP3564_07145	COG1129	ABC transporter
AP3564_07150	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_07155	COG1879	ABC-type sugar transport system periplasmic component
AP3564_07160	COG0673	inositol 2-dehydrogenase activity
AP3564_07165	COG0191	fructose-bisphosphate aldolase activity
AP3564_07175	COG0247	lactate metabolic process
AP3564_07180	COG0277	FAD linked oxidase domain protein
AP3564_07185	COG2186	Transcriptional regulator
AP3564_07195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AP3564_07215	COG1914	H( )-stimulated, divalent metal cation uptake system
AP3564_07220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_07225	COG1984	allophanate hydrolase subunit 2
AP3564_07230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_07235	COG1414	Transcriptional regulator
AP3564_07260	COG4336	lyase activity
AP3564_07290	COG3711	transcriptional antiterminator
AP3564_07315	COG1131	(ABC) transporter
AP3564_07330	COG3842	ATPase activity
AP3564_07360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AP3564_07365	COG0303	'Molybdopterin
AP3564_07375	COG0803	Belongs to the bacterial solute-binding protein 9 family
AP3564_07380	COG1121	(ABC) transporter
AP3564_07385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_07385	COG1321	iron dependent repressor
AP3564_07390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_07395	COG1321	iron dependent repressor
AP3564_07405	COG3764	Sortase (surface protein transpeptidase)
AP3564_07410	COG1113	amino acid transport
AP3564_07415	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_07415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_07430	COG0681	Belongs to the peptidase S26 family
AP3564_07465	COG3730	PTS system glucitol sorbitol-specific
AP3564_07470	COG3732	PTS system glucitol sorbitol-specific
AP3564_07480	COG2390	Transcriptional regulator
AP3564_07485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_07490	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_07490	COG0022	dehydrogenase e1 component
AP3564_07495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_07500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP3564_07505	COG2390	Transcriptional regulator
AP3564_07515	COG3290	protein histidine kinase activity
AP3564_07520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_07525	COG1301	dicarboxylic acid transport
AP3564_07530	COG1482	cell wall glycoprotein biosynthetic process
AP3564_07545	COG1316	TRANSCRIPTIONal
AP3564_07555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP3564_07565	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AP3564_07575	COG0463	Glycosyl transferase, family 2
AP3564_07585	COG2076	Multidrug Resistance protein
AP3564_07605	COG4193	domain, Protein
AP3564_07610	COG0728	peptidoglycan biosynthetic process
AP3564_07615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_07620	COG0438	transferase activity, transferring glycosyl groups
AP3564_07625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AP3564_07630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_07635	COG1316	TRANSCRIPTIONal
AP3564_07640	COG1739	Uncharacterized protein family UPF0029
AP3564_07645	COG4585	Histidine kinase
AP3564_07650	COG2197	response regulator
AP3564_07655	COG1307	EDD domain protein, DegV family
AP3564_07660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AP3564_07670	COG1040	competence protein
AP3564_07690	COG1256	bacterial-type flagellum assembly
AP3564_07690	COG4786	Flagellar basal body rod
AP3564_07695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP3564_07705	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AP3564_07710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AP3564_07715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP3564_07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP3564_07740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AP3564_07745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP3564_07750	COG2089	acid synthase
AP3564_07760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP3564_07780	COG2337	Toxic component of a toxin-antitoxin (TA) module
AP3564_07800	COG0604	alcohol dehydrogenase
AP3564_07815	COG1309	transcriptional regulator
AP3564_07820	COG1388	LysM domain
AP3564_07820	COG3584	3D domain protein
AP3564_07830	COG0670	Belongs to the BI1 family
AP3564_07835	COG3290	protein histidine kinase activity
AP3564_07835	COG3829	transcription factor binding
AP3564_07840	COG1454	alcohol dehydrogenase
AP3564_07850	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_07855	COG2814	Major facilitator Superfamily
AP3564_07865	COG3711	transcriptional antiterminator
AP3564_07870	COG2723	6-phospho-beta-galactosidase activity
AP3564_07875	COG2723	6-phospho-beta-galactosidase activity
AP3564_07880	COG2190	(PTS) system
AP3564_07880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_07880	COG1263	PTS System
AP3564_07885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_07890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_07895	COG1116	anion transmembrane transporter activity
AP3564_07900	COG0840	transmembrane signaling receptor activity
AP3564_07900	COG5278	phosphoserine phosphatase activity
AP3564_07910	COG3665	Urea carboxylase-associated protein
AP3564_07915	COG0439	Biotin carboxylase
AP3564_07925	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_07930	COG1879	ABC-type sugar transport system periplasmic component
AP3564_07945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP3564_07955	COG1454	alcohol dehydrogenase
AP3564_07970	COG2508	Transcriptional regulator
AP3564_08005	COG3344	reverse transcriptase
AP3564_08040	COG4152	abc transporter atp-binding protein
AP3564_08045	COG1668	transmembrane transport
AP3564_08050	COG0840	transmembrane signaling receptor activity
AP3564_08055	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_08055	COG3347	Dehydrogenase
AP3564_08060	COG1349	DNA-binding transcription factor activity
AP3564_08065	COG4154	Belongs to the RbsD FucU family
AP3564_08070	COG1070	Carbohydrate kinase
AP3564_08075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP3564_08080	COG1129	ABC transporter
AP3564_08105	COG0235	Class ii aldolase
AP3564_08110	COG1070	Carbohydrate kinase
AP3564_08120	COG1069	ribulokinase activity
AP3564_08125	COG0183	Belongs to the thiolase family
AP3564_08130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AP3564_08135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AP3564_08140	COG0583	DNA-binding transcription factor activity
AP3564_08145	COG0145	ligase activity
AP3564_08150	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AP3564_08155	COG4647	ligase activity
AP3564_08170	COG4585	Histidine kinase
AP3564_08175	COG2197	response regulator
AP3564_08180	COG1131	(ABC) transporter
AP3564_08195	COG1132	(ABC) transporter
AP3564_08205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AP3564_08220	COG1376	ErfK ybiS ycfS ynhG family protein
AP3564_08230	COG3842	ATPase activity
AP3564_08235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AP3564_08250	COG1442	glycosyl transferase family 8
AP3564_08265	COG2508	Transcriptional regulator
AP3564_08270	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_08275	COG1024	Enoyl-CoA hydratase
AP3564_08280	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_08290	COG1960	acyl-CoA dehydrogenase activity
AP3564_08300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP3564_08310	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AP3564_08325	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_08350	COG1334	flagellar protein FlaG
AP3564_08355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AP3564_08360	COG1516	flagellar protein fliS
AP3564_08370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AP3564_08375	COG0653	protein targeting
AP3564_08380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AP3564_08385	COG2010	Cytochrome c
AP3564_08390	COG2884	Cell division ATP-binding protein ftsE
AP3564_08395	COG2177	Part of the ABC transporter FtsEX involved in
AP3564_08400	COG0739	heme binding
AP3564_08405	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_08405	COG0793	Belongs to the peptidase S41A family
AP3564_08410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_08415	COG2072	flavoprotein involved in K transport
AP3564_08420	COG1230	cation diffusion facilitator family transporter
AP3564_08425	COG0640	Transcriptional regulator
AP3564_08455	COG1940	carbohydrate kinase activity
AP3564_08465	COG0556	nucleotide-excision repair
AP3564_08470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AP3564_08475	COG1960	acyl-CoA dehydrogenase activity
AP3564_08485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AP3564_08490	COG0765	amino acid transport
AP3564_08495	COG0765	amino acid transport
AP3564_08505	COG1950	PFAM Membrane protein of
AP3564_08510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AP3564_08515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AP3564_08520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP3564_08525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AP3564_08530	COG0546	phosphoglycolate phosphatase activity
AP3564_08535	COG0110	maltose O-acetyltransferase activity
AP3564_08540	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AP3564_08545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AP3564_08550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AP3564_08555	COG0131	Imidazoleglycerol-phosphate dehydratase
AP3564_08560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AP3564_08565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AP3564_08570	COG0107	imidazoleglycerol-phosphate synthase activity
AP3564_08575	COG0140	phosphoribosyl-ATP diphosphatase activity
AP3564_08575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AP3564_08580	COG0457	Tetratricopeptide repeat
AP3564_08585	COG0492	ferredoxin-NADP+ reductase activity
AP3564_08590	COG1051	belongs to the nudix hydrolase family
AP3564_08595	COG1660	Displays ATPase and GTPase activities
AP3564_08600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AP3564_08605	COG1481	regulation of sporulation
AP3564_08610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_08615	COG0740	serine-type endopeptidase activity
AP3564_08630	COG3279	Response regulator of the LytR AlgR family
AP3564_08635	COG0427	acetyl-CoA hydrolase
AP3564_08640	COG1929	Belongs to the glycerate kinase type-1 family
AP3564_08650	COG1486	melibiose metabolic process
AP3564_08710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP3564_08715	COG1609	Transcriptional regulator
AP3564_08720	COG0477	Major facilitator Superfamily
AP3564_08740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_08755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AP3564_08775	COG0126	phosphoglycerate kinase activity
AP3564_08790	COG0148	phosphopyruvate hydratase activity
AP3564_08800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP3564_08805	COG1647	Serine aminopeptidase, S33
AP3564_08810	COG0557	exoribonuclease II activity
AP3564_08815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AP3564_08830	COG0788	formyltetrahydrofolate deformylase activity
AP3564_08835	COG0789	Transcriptional regulator
AP3564_08840	COG0114	fumarate hydratase activity
AP3564_08850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP3564_08855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_08860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_08865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_08870	COG1120	ATPase activity
AP3564_08885	COG5577	PFAM Coat F domain
AP3564_08895	COG1024	Enoyl-CoA hydratase
AP3564_08895	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_08900	COG0183	Belongs to the thiolase family
AP3564_08905	COG1960	acyl-CoA dehydrogenase activity
AP3564_08910	COG1393	Belongs to the ArsC family
AP3564_08915	COG0509	glycine decarboxylation via glycine cleavage system
AP3564_08920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AP3564_08925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_08935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_08940	COG2011	ABC-type metal ion transport system permease component
AP3564_08945	COG1464	Belongs to the NlpA lipoprotein family
AP3564_08955	COG0396	ATPase activity
AP3564_08960	COG0719	Fe-S assembly protein
AP3564_08965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP3564_08970	COG0822	iron-sulfur transferase activity
AP3564_08975	COG0719	Fe-S assembly protein
AP3564_08990	COG1801	Protein of unknown function DUF72
AP3564_08995	COG0737	Belongs to the 5'-nucleotidase family
AP3564_09000	COG3377	Domain of unknown function (DUF1805)
AP3564_09005	COG0739	heme binding
AP3564_09010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AP3564_09020	COG4470	Protein conserved in bacteria
AP3564_09035	COG2445	Protein of unknown function DUF86
AP3564_09040	COG0647	UMP catabolic process
AP3564_09045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AP3564_09050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AP3564_09055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_09060	COG0460	homoserine dehydrogenase
AP3564_09065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AP3564_09070	COG0083	homoserine kinase activity
AP3564_09075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AP3564_09080	COG4837	Protein of unknown function (DUF1462)
AP3564_09085	COG1252	NADH dehydrogenase
AP3564_09095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AP3564_09100	COG0316	Belongs to the HesB IscA family
AP3564_09105	COG0492	ferredoxin-NADP+ reductase activity
AP3564_09110	COG1252	NADH dehydrogenase
AP3564_09120	COG3584	3D domain protein
AP3564_09125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AP3564_09135	COG0686	Belongs to the AlaDH PNT family
AP3564_09140	COG1418	mRNA catabolic process
AP3564_09165	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_09170	COG2610	gluconate transmembrane transporter activity
AP3564_09200	COG0142	geranyltranstransferase activity
AP3564_09205	COG4585	Histidine kinase
AP3564_09210	COG2197	response regulator
AP3564_09215	COG1320	monovalent cation:proton antiporter activity
AP3564_09220	COG2212	antiporter activity
AP3564_09225	COG1863	multisubunit Na H antiporter MnhE subunit
AP3564_09230	COG0651	ATP synthesis coupled electron transport
AP3564_09235	COG1006	Multisubunit Na H antiporter MnhC subunit
AP3564_09240	COG2111	Na H antiporter
AP3564_09245	COG2111	Na H antiporter
AP3564_09245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP3564_09255	COG3011	Protein conserved in bacteria
AP3564_09260	COG5018	Exonuclease
AP3564_09275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AP3564_09285	COG2267	carboxylic ester hydrolase activity
AP3564_09290	COG1522	sequence-specific DNA binding
AP3564_09295	COG0436	Aminotransferase
AP3564_09300	COG1098	S1 RNA binding domain
AP3564_09305	COG2155	Conserved Protein
AP3564_09310	COG0166	Belongs to the GPI family
AP3564_09320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AP3564_09330	COG2738	Putative neutral zinc metallopeptidase
AP3564_09335	COG0432	Pfam Uncharacterised protein family UPF0047
AP3564_09460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AP3564_09465	COG1575	Belongs to the MenA family. Type 1 subfamily
AP3564_09470	COG1169	isochorismate synthase
AP3564_09480	COG0596	Alpha beta hydrolase
AP3564_09485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AP3564_09490	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_09500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AP3564_09505	COG1854	S-ribosylhomocysteine lyase activity
AP3564_09510	COG0783	Belongs to the Dps family
AP3564_09520	COG0494	nUDIX hydrolase
AP3564_09525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_09530	COG1116	anion transmembrane transporter activity
AP3564_09535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_09540	COG1506	peptidase
AP3564_09560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AP3564_09565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AP3564_09575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AP3564_09590	COG2267	carboxylic ester hydrolase activity
AP3564_09600	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AP3564_09605	COG1242	4 iron, 4 sulfur cluster binding
AP3564_09615	COG1725	Transcriptional regulator
AP3564_09620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_09625	COG0495	leucyl-tRNA aminoacylation
AP3564_09630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_09640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP3564_09640	COG1648	precorrin-2 dehydrogenase activity
AP3564_09655	COG2081	HI0933 family
AP3564_09660	COG2244	polysaccharide biosynthetic process
AP3564_09665	COG1187	pseudouridine synthase activity
AP3564_09670	COG1349	DNA-binding transcription factor activity
AP3564_09680	COG2252	PERMEase
AP3564_09685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_09690	COG2076	Multidrug Resistance protein
AP3564_09695	COG2076	Multidrug Resistance protein
AP3564_09700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP3564_09710	COG1380	Effector of murein hydrolase LrgA
AP3564_09715	COG1346	cytolysis
AP3564_09725	COG0510	thiamine kinase activity
AP3564_09735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AP3564_09740	COG0010	Belongs to the arginase family
AP3564_09745	COG5584	Small secreted protein
AP3564_09750	COG1363	Peptidase, m42
AP3564_09755	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AP3564_09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_09765	COG4848	Belongs to the UPF0354 family
AP3564_09770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP3564_09775	COG1288	antiporter activity
AP3564_09780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AP3564_09785	COG2224	Isocitrate lyase
AP3564_09795	COG4903	ComK protein
AP3564_09805	COG0398	Pfam SNARE associated Golgi protein
AP3564_09810	COG0681	Belongs to the peptidase S26 family
AP3564_09815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AP3564_09820	COG1074	ATP-dependent DNA helicase activity
AP3564_09825	COG1074	ATP-dependent DNA helicase activity
AP3564_09830	COG0420	3'-5' exonuclease activity
AP3564_09835	COG0419	ATPase involved in DNA repair
AP3564_09870	COG1959	2 iron, 2 sulfur cluster binding
AP3564_09875	COG5583	Uncharacterized small protein (DUF2292)
AP3564_09880	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AP3564_09885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AP3564_09890	COG4208	sulfate ABC transporter
AP3564_09900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_09915	COG0084	hydrolase, TatD family'
AP3564_09920	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_09935	COG0367	asparagine synthase
AP3564_09955	COG2706	6-phosphogluconolactonase activity
AP3564_09960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AP3564_09970	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_09975	COG1410	methionine synthase
AP3564_09975	COG0646	methionine synthase
AP3564_09980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AP3564_09980	COG0646	methionine synthase
AP3564_09985	COG1666	GTP binding
AP3564_10005	COG1307	EDD domain protein, DegV family
AP3564_10015	COG0561	phosphatase activity
AP3564_10020	COG1073	alpha beta
AP3564_10025	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_10030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AP3564_10035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AP3564_10050	COG0505	Belongs to the CarA family
AP3564_10055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AP3564_10060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AP3564_10090	COG1744	ABC transporter substrate-binding protein PnrA-like
AP3564_10100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_10105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AP3564_10110	COG5504	Zn-dependent protease
AP3564_10125	COG0180	Tryptophanyl-tRNA synthetase
AP3564_10130	COG1393	Belongs to the ArsC family
AP3564_10135	COG0861	Integral membrane protein TerC family
AP3564_10140	COG4862	establishment of competence for transformation
AP3564_10145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AP3564_10150	COG4469	Competence protein
AP3564_10155	COG1164	Oligoendopeptidase f
AP3564_10165	COG2346	COG2346, Truncated hemoglobins
AP3564_10170	COG0741	lytic transglycosylase activity
AP3564_10175	COG4116	CYTH
AP3564_10185	COG2357	RelA SpoT domain protein
AP3564_10190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AP3564_10195	COG0564	pseudouridine synthase activity
AP3564_10200	COG2239	Acts as a magnesium transporter
AP3564_10205	COG0475	glutathione-regulated potassium exporter activity
AP3564_10205	COG0569	domain protein
AP3564_10210	COG0352	thiamine-phosphate diphosphorylase activity
AP3564_10215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_10220	COG2104	thiamine diphosphate biosynthetic process
AP3564_10225	COG2022	thiamine diphosphate biosynthetic process
AP3564_10230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AP3564_10235	COG0351	phosphomethylpyrimidine kinase
AP3564_10240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AP3564_10300	COG2323	membrane
AP3564_10305	COG2153	protein acetylation
AP3564_10310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AP3564_10315	COG2382	esterase
AP3564_10330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_10340	COG0626	cystathionine gamma-synthase activity
AP3564_10345	COG0626	cystathionine gamma-synthase activity
AP3564_10370	COG2333	competence protein COMEC
AP3564_10370	COG0658	competence protein
AP3564_10380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AP3564_10390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AP3564_10420	COG1024	Enoyl-CoA hydratase
AP3564_10425	COG0477	Major facilitator Superfamily
AP3564_10460	COG4990	cell redox homeostasis
AP3564_10465	COG0367	asparagine synthase
AP3564_10580	COG2190	(PTS) system
AP3564_10585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_10585	COG1263	PTS System
AP3564_10590	COG0366	Alpha amylase catalytic
AP3564_10595	COG2188	Transcriptional regulator
AP3564_10600	COG3344	reverse transcriptase
AP3564_10645	COG5002	protein histidine kinase activity
AP3564_10645	COG3850	Histidine kinase
AP3564_10650	COG0745	RESPONSE REGULATOR receiver
AP3564_10680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_10685	COG0785	Cytochrome C biogenesis protein
AP3564_10690	COG1937	Protein conserved in bacteria
AP3564_10695	COG2217	Heavy metal translocating P-type atpase
AP3564_10710	COG2132	Multicopper oxidase
AP3564_10725	COG4372	Transposase
AP3564_10730	COG1609	Transcriptional regulator
AP3564_10735	COG1263	PTS System
AP3564_10735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_10740	COG1621	beta-fructofuranosidase activity
AP3564_10745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_10750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AP3564_10755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP3564_10770	COG0717	Belongs to the dCTP deaminase family
AP3564_10775	COG0523	cobalamin synthesis protein
AP3564_10790	COG0693	protein deglycase activity
AP3564_10795	COG3835	regulator
AP3564_10800	COG0277	FAD linked oxidase domain protein
AP3564_10805	COG0247	lactate metabolic process
AP3564_10810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_10850	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AP3564_10865	COG4372	Transposase
AP3564_10930	COG0277	FAD linked oxidase domain protein
AP3564_10935	COG0247	lactate metabolic process
AP3564_10940	COG0579	oxidoreductase
AP3564_10980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_11000	COG4988	ABC transporter
AP3564_11005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AP3564_11010	COG1294	oxidase, subunit
AP3564_11015	COG1271	oxidase subunit
AP3564_11025	COG1131	(ABC) transporter
AP3564_11040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AP3564_11045	COG3383	formate dehydrogenase (NAD+) activity
AP3564_11050	COG2427	Protein of unknown function (DUF1641)
AP3564_11055	COG0326	Molecular chaperone. Has ATPase activity
AP3564_11065	COG1408	metallophosphoesterase
AP3564_11075	COG2814	Major facilitator Superfamily
AP3564_11100	COG0824	Thioesterase
AP3564_11105	COG1021	2,3-dihydroxybenzoate-AMP ligase
AP3564_11115	COG2884	Cell division ATP-binding protein ftsE
AP3564_11135	COG0840	transmembrane signaling receptor activity
AP3564_11160	COG1476	TRANSCRIPTIONal
AP3564_11165	COG1414	Transcriptional regulator
AP3564_11170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP3564_11210	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_11215	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_11220	COG0183	Belongs to the thiolase family
AP3564_11225	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_11230	COG1024	Enoyl-CoA hydratase
AP3564_11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_11255	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_11270	COG1024	Enoyl-CoA hydratase
AP3564_11275	COG1024	Enoyl-CoA hydratase
AP3564_11290	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_11295	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_11310	COG1725	Transcriptional regulator
AP3564_11315	COG1131	(ABC) transporter
AP3564_11325	COG1595	DNA-templated transcription, initiation
AP3564_11350	COG2322	membrane
AP3564_11355	COG0589	response to stress
AP3564_11395	COG0726	polysaccharide deacetylase
AP3564_11405	COG0492	ferredoxin-NADP+ reductase activity
AP3564_11410	COG3773	Cell wall hydrolase
AP3564_11415	COG3344	reverse transcriptase
AP3564_11435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_11440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_11445	COG1120	ATPase activity
AP3564_11450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AP3564_11455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP3564_11470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AP3564_11495	COG0789	Transcriptional regulator
AP3564_11500	COG1253	flavin adenine dinucleotide binding
AP3564_11505	COG3002	Belongs to the UPF0753 family
AP3564_11510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP3564_11515	COG5609	conserved protein (DUF2294)
AP3564_11520	COG0527	aspartate kinase activity
AP3564_11525	COG0840	transmembrane signaling receptor activity
AP3564_11530	COG1846	Transcriptional regulator
AP3564_11535	COG5001	Diguanylate cyclase
AP3564_11535	COG3300	MHYT domain
AP3564_11545	COG1793	dna ligase
AP3564_11545	COG3285	dna ligase
AP3564_11550	COG0131	Imidazoleglycerol-phosphate dehydratase
AP3564_11550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AP3564_11555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AP3564_11560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP3564_11570	COG4175	Glycine betaine
AP3564_11570	COG0517	IMP dehydrogenase activity
AP3564_11600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP3564_11605	COG0768	penicillin binding
AP3564_11610	COG1032	radical SAM domain protein
AP3564_11615	COG2186	Transcriptional regulator
AP3564_11620	COG0247	lactate metabolic process
AP3564_11625	COG1139	Iron-sulfur cluster binding protein
AP3564_11630	COG1556	Lactate utilization protein
AP3564_11635	COG3594	Acyltransferase
AP3564_11640	COG5002	protein histidine kinase activity
AP3564_11645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AP3564_11650	COG3853	Toxic anion resistance protein (TelA)
AP3564_11655	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AP3564_11660	COG0393	Putative heavy-metal-binding
AP3564_11680	COG3852	Histidine kinase
AP3564_11685	COG1846	Transcriptional regulator
AP3564_11695	COG1360	Flagellar Motor Protein
AP3564_11700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AP3564_11705	COG0542	response to heat
AP3564_11710	COG3949	Membrane
AP3564_11715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AP3564_11720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AP3564_11725	COG0720	synthase
AP3564_11745	COG4873	Protein conserved in bacteria
AP3564_11775	COG2244	polysaccharide biosynthetic process
AP3564_11780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_11785	COG2217	Heavy metal translocating P-type atpase
AP3564_11795	COG1525	nuclease
AP3564_11800	COG0205	6-phosphofructokinase activity
AP3564_11820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AP3564_11825	COG3711	transcriptional antiterminator
AP3564_11830	COG1263	PTS System
AP3564_11830	COG2190	(PTS) system
AP3564_11830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_11835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_11840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AP3564_11845	COG0840	transmembrane signaling receptor activity
AP3564_11850	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_11855	COG2084	Dehydrogenase
AP3564_11860	COG2340	Cysteine-rich secretory protein family
AP3564_11865	COG0768	penicillin binding
AP3564_11870	COG4191	Histidine kinase
AP3564_11875	COG0436	Aminotransferase
AP3564_11880	COG0598	Magnesium transport protein CorA
AP3564_11895	COG0835	chemotaxis
AP3564_11895	COG0784	Response regulator, receiver
AP3564_11905	COG0640	Transcriptional regulator
AP3564_11910	COG2814	Major facilitator Superfamily
AP3564_11915	COG1408	metallophosphoesterase
AP3564_11930	COG2200	EAL domain
AP3564_11940	COG1120	ATPase activity
AP3564_11950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_11955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_11960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_11970	COG0517	IMP dehydrogenase activity
AP3564_11975	COG0477	Major facilitator Superfamily
AP3564_11980	COG0583	DNA-binding transcription factor activity
AP3564_11985	COG2171	N-acyltransferase activity
AP3564_11990	COG1473	amidohydrolase
AP3564_11995	COG0668	transmembrane transport
AP3564_12000	COG0450	alkyl hydroperoxide reductase
AP3564_12005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_12015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_12020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AP3564_12025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AP3564_12035	COG1122	ATPase activity
AP3564_12050	COG0559	Belongs to the binding-protein-dependent transport system permease family
AP3564_12070	COG0831	urea catabolic process
AP3564_12075	COG0832	Belongs to the urease beta subunit family
AP3564_12085	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AP3564_12125	COG1119	ATPase activity
AP3564_12130	COG0402	S-adenosylhomocysteine deaminase activity
AP3564_12165	COG0402	S-adenosylhomocysteine deaminase activity
AP3564_12170	COG0655	NAD(P)H dehydrogenase (quinone) activity
AP3564_12175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AP3564_12185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AP3564_12190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AP3564_12195	COG2080	2 iron, 2 sulfur cluster binding
AP3564_12205	COG2351	hydroxyisourate hydrolase activity
AP3564_12215	COG2233	PERMEase
AP3564_12220	COG2508	Transcriptional regulator
AP3564_12225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_12230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AP3564_12235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AP3564_12250	COG0673	inositol 2-dehydrogenase activity
AP3564_12260	COG1061	Type III restriction enzyme res subunit
AP3564_12305	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP3564_12335	COG1349	DNA-binding transcription factor activity
AP3564_12340	COG1105	Belongs to the carbohydrate kinase PfkB family
AP3564_12345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_12345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP3564_12345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP3564_12355	COG1492	cobalamin metabolic process
AP3564_12365	COG3835	regulator
AP3564_12370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_12375	COG2059	Chromate
AP3564_12380	COG2059	Chromate
AP3564_12385	COG1522	sequence-specific DNA binding
AP3564_12400	COG0405	Gamma-glutamyltransferase
AP3564_12420	COG4152	abc transporter atp-binding protein
AP3564_12425	COG1131	(ABC) transporter
AP3564_12445	COG1331	Highly conserved protein containing a thioredoxin domain
AP3564_12460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP3564_12475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP3564_12480	COG1136	(ABC) transporter
AP3564_12485	COG0577	efflux transmembrane transporter activity
AP3564_12490	COG0772	Belongs to the SEDS family
AP3564_12515	COG2309	aminopeptidase activity
AP3564_12520	COG1960	acyl-CoA dehydrogenase activity
AP3564_12525	COG2223	nitrite transmembrane transporter activity
AP3564_12540	COG0583	DNA-binding transcription factor activity
AP3564_12545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AP3564_12550	COG4637	Psort location Cytoplasmic, score
AP3564_12555	COG0569	domain protein
AP3564_12560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AP3564_12570	COG0561	phosphatase activity
AP3564_12575	COG0242	peptide deformylase activity
AP3564_12585	COG0022	dehydrogenase e1 component
AP3564_12590	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_12600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_12610	COG1476	TRANSCRIPTIONal
AP3564_12635	COG1131	(ABC) transporter
AP3564_12665	COG0697	spore germination
AP3564_12670	COG1982	Orn Lys Arg decarboxylase major
AP3564_12695	COG4493	Belongs to the UPF0637 family
AP3564_12700	COG0483	inositol monophosphate 1-phosphatase activity
AP3564_12720	COG4896	Protein conserved in bacteria
AP3564_12730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AP3564_12735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AP3564_12740	COG4838	Belongs to the UPF0358 family
AP3564_12745	COG0772	Belongs to the SEDS family
AP3564_12750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AP3564_12765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AP3564_12775	COG0328	RNA-DNA hybrid ribonuclease activity
AP3564_12790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_12795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AP3564_12800	COG0386	Belongs to the glutathione peroxidase family
AP3564_12805	COG1413	lyase activity
AP3564_12820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AP3564_12825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AP3564_12830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AP3564_12835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AP3564_12845	COG1307	EDD domain protein, DegV family
AP3564_12850	COG1999	signal sequence binding
AP3564_12885	COG2755	lipolytic protein G-D-S-L family
AP3564_12890	COG4698	Protein conserved in bacteria
AP3564_12895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AP3564_12895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP3564_12905	COG2814	Major facilitator Superfamily
AP3564_12910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_12910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_12920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AP3564_12925	COG4479	Belongs to the UPF0346 family
AP3564_12940	COG0515	serine threonine protein kinase
AP3564_12945	COG4326	sporulation control protein
AP3564_12955	COG0671	phosphoesterase, PA-phosphatase related
AP3564_12970	COG1876	peptidase activity
AP3564_12975	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_12975	COG0793	Belongs to the peptidase S41A family
AP3564_12995	COG2962	Rard protein
AP3564_13005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AP3564_13010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AP3564_13015	COG1388	LysM domain
AP3564_13015	COG0791	NLP P60 protein
AP3564_13045	COG0833	amino acid
AP3564_13050	COG0714	Associated with various cellular activities
AP3564_13055	COG4548	von Willebrand factor, type A
AP3564_13060	COG0567	Dehydrogenase, E1 component
AP3564_13065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_13075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AP3564_13080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AP3564_13090	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_13110	COG3546	catalase activity
AP3564_13120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AP3564_13175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_13190	COG2323	membrane
AP3564_13195	COG0492	ferredoxin-NADP+ reductase activity
AP3564_13210	COG0129	dihydroxy-acid dehydratase activity
AP3564_13215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AP3564_13225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_13245	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_13250	COG0534	Mate efflux family protein
AP3564_13260	COG0477	Major facilitator Superfamily
AP3564_13265	COG1309	transcriptional regulator
AP3564_13270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AP3564_13315	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_13320	COG1937	Protein conserved in bacteria
AP3564_13325	COG2217	Heavy metal translocating P-type atpase
AP3564_13330	COG2608	mercury ion transmembrane transporter activity
AP3564_13360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP3564_13360	COG2199	diguanylate cyclase activity
AP3564_13385	COG1566	PFAM secretion protein HlyD family protein
AP3564_13390	COG2814	Major facilitator Superfamily
AP3564_13400	COG0039	L-malate dehydrogenase activity
AP3564_13405	COG2258	MOSC domain
AP3564_13420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AP3564_13425	COG2079	MmgE PrpD family protein
AP3564_13430	COG0372	Belongs to the citrate synthase family
AP3564_13445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AP3564_13450	COG0667	Aldo Keto reductase
AP3564_13455	COG0723	plastoquinol--plastocyanin reductase activity
AP3564_13455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_13460	COG3275	phosphorelay sensor kinase activity
AP3564_13470	COG1966	Carbon starvation protein
AP3564_13475	COG1309	transcriptional regulator
AP3564_13480	COG0673	inositol 2-dehydrogenase activity
AP3564_13485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP3564_13505	COG3226	Transcriptional regulator
AP3564_13520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AP3564_13535	COG1595	DNA-templated transcription, initiation
AP3564_13545	COG1846	Transcriptional regulator
AP3564_13550	COG1033	growth of symbiont in host cell
AP3564_13550	COG2409	Drug exporters of the RND superfamily
AP3564_13555	COG3858	chitin binding
AP3564_13555	COG1388	LysM domain
AP3564_13570	COG1278	Cold shock
AP3564_13575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP3564_13575	COG0551	DNA topoisomerase type I activity
AP3564_13580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP3564_13600	COG2814	Major facilitator Superfamily
AP3564_13615	COG0561	phosphatase activity
AP3564_13625	COG1509	lysine 2,3-aminomutase activity
AP3564_13630	COG3239	Fatty acid desaturase
AP3564_13635	COG4585	Histidine kinase
AP3564_13640	COG2197	response regulator
AP3564_13650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_13650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_13690	COG0517	IMP dehydrogenase activity
AP3564_13700	COG4221	oxidoreductase activity
AP3564_13705	COG2203	Gaf domain
AP3564_13705	COG4585	Histidine kinase
AP3564_13710	COG2197	response regulator
AP3564_13715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AP3564_13720	COG0366	Alpha amylase catalytic
AP3564_13730	COG2879	small protein
AP3564_13740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_13745	COG2104	thiamine diphosphate biosynthetic process
AP3564_13750	COG2022	thiamine diphosphate biosynthetic process
AP3564_13765	COG3842	ATPase activity
AP3564_13770	COG2508	Transcriptional regulator
AP3564_13795	COG0367	asparagine synthase
AP3564_13800	COG0534	Mate efflux family protein
AP3564_13805	COG2207	Transcriptional regulator
AP3564_13805	COG1917	Cupin 2, conserved barrel domain protein
AP3564_13815	COG2182	Extracellular solute-binding protein
AP3564_13820	COG1175	transmembrane transport
AP3564_13825	COG3833	ABC-type maltose transport systems, permease component
AP3564_13830	COG0366	Alpha amylase catalytic
AP3564_13855	COG2963	transposase activity
AP3564_13880	COG1937	Protein conserved in bacteria
AP3564_13885	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_13890	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_13900	COG0589	response to stress
AP3564_13920	COG0785	Cytochrome C biogenesis protein
AP3564_13925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_13930	COG0745	RESPONSE REGULATOR receiver
AP3564_13935	COG2205	protein histidine kinase activity
AP3564_13940	COG1388	LysM domain
AP3564_13940	COG3858	chitin binding
AP3564_13945	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_13955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_13955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_13960	COG2226	methyltransferase
AP3564_13970	COG1937	Protein conserved in bacteria
AP3564_13975	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_13980	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_13990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_13995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_13995	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_14000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_14000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_14005	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_14010	COG0730	response to heat
AP3564_14035	COG0583	DNA-binding transcription factor activity
AP3564_14050	COG2217	Heavy metal translocating P-type atpase
AP3564_14090	COG0640	Transcriptional regulator
AP3564_14095	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_14095	COG1454	alcohol dehydrogenase
AP3564_14125	COG1683	Conserved Protein
AP3564_14135	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
AP3564_14145	COG0156	8-amino-7-oxononanoate synthase activity
AP3564_14150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP3564_14155	COG3829	transcription factor binding
AP3564_14155	COG3290	protein histidine kinase activity
AP3564_14165	COG1454	alcohol dehydrogenase
AP3564_14185	COG3655	Transcriptional regulator
AP3564_14210	COG0385	Bile acid
AP3564_14225	COG0488	(ABC) transporter
AP3564_14230	COG0500	methyltransferase
AP3564_14240	COG1309	transcriptional regulator
AP3564_14245	COG1960	acyl-CoA dehydrogenase activity
AP3564_14250	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_14255	COG0439	Biotin carboxylase
AP3564_14260	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_14265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_14270	COG1024	Enoyl-CoA hydratase
AP3564_14275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AP3564_14280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AP3564_14285	COG4149	molybdate abc transporter
AP3564_14290	COG1910	domain protein
AP3564_14295	COG3344	reverse transcriptase
AP3564_14305	COG0725	ABC transporter, periplasmic molybdate-binding protein
AP3564_14315	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_14320	COG3586	endonuclease activity
AP3564_14330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_14340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_14345	COG2011	ABC-type metal ion transport system permease component
AP3564_14350	COG0640	Transcriptional regulator
AP3564_14355	COG0798	PFAM Bile acid sodium symporter
AP3564_14360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_14365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_14370	COG1279	arginine transmembrane transporter activity
AP3564_14375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP3564_14380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP3564_14385	COG2226	methyltransferase
AP3564_14420	COG4372	Transposase
AP3564_14435	COG1725	Transcriptional regulator
AP3564_14515	COG1064	alcohol dehydrogenase
AP3564_14520	COG1309	transcriptional regulator
AP3564_14525	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_14530	COG2207	Transcriptional regulator
AP3564_14535	COG0656	L-ascorbic acid biosynthetic process
AP3564_14570	COG0390	transport system, permease component
AP3564_14590	COG0315	cyclic pyranopterin monophosphate synthase activity
AP3564_14605	COG0314	molybdopterin synthase activity
AP3564_14610	COG1763	Mo-molybdopterin cofactor biosynthetic process
AP3564_14615	COG0303	'Molybdopterin
AP3564_14620	COG0746	molybdenum cofactor guanylyltransferase activity
AP3564_14655	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_14665	COG0535	radical SAM domain protein
AP3564_14670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP3564_14695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP3564_14700	COG0187	DNA topoisomerase II activity
AP3564_14705	COG1832	CoA-binding protein
AP3564_14710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AP3564_14715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AP3564_14715	COG1199	ATP-dependent helicase activity
AP3564_14725	COG0004	ammonium transporteR
AP3564_14735	COG4841	protein insertion into membrane
AP3564_14745	COG0824	Thioesterase
AP3564_14760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_14765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AP3564_14790	COG4846	Membrane protein involved in cytochrome C biogenesis
AP3564_14795	COG2201	protein-glutamate methylesterase activity
AP3564_14800	COG0785	Cytochrome C biogenesis protein
AP3564_14805	COG3763	UPF0154 protein
AP3564_14820	COG4224	UPF0291 protein
AP3564_14825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AP3564_14835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP3564_14840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AP3564_14845	COG0204	Acyl-transferase
AP3564_14850	COG1611	Belongs to the LOG family
AP3564_14855	COG0667	Aldo Keto reductase
AP3564_14860	COG0400	carboxylic ester hydrolase activity
AP3564_14865	COG0346	lactoylglutathione lyase activity
AP3564_14875	COG1609	Transcriptional regulator
AP3564_14900	COG4585	Histidine kinase
AP3564_14905	COG2197	response regulator
AP3564_14915	COG0840	transmembrane signaling receptor activity
AP3564_14925	COG2200	EAL domain
AP3564_14955	COG3180	Ammonia monooxygenase
AP3564_14960	COG0583	DNA-binding transcription factor activity
AP3564_14975	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_14980	COG0745	RESPONSE REGULATOR receiver
AP3564_14985	COG3850	Histidine kinase
AP3564_14985	COG5002	protein histidine kinase activity
AP3564_14995	COG0310	cobalt ion transport
AP3564_15025	COG1136	(ABC) transporter
AP3564_15065	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_15085	COG1970	mechanosensitive ion channel activity
AP3564_15185	COG3706	GGDEF domain
AP3564_15185	COG0745	RESPONSE REGULATOR receiver
AP3564_15190	COG0784	Response regulator, receiver
AP3564_15190	COG0835	chemotaxis
AP3564_15300	COG0405	Gamma-glutamyltransferase
AP3564_15310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_15335	COG0395	ABC-type sugar transport system, permease component
AP3564_15340	COG1175	transmembrane transport
AP3564_15345	COG1653	transport
AP3564_15355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_15360	COG2188	Transcriptional regulator
AP3564_15370	COG2222	sugar isomerase
AP3564_15385	COG0210	DNA helicase
AP3564_15395	COG1074	ATP-dependent DNA helicase activity
AP3564_15475	COG2801	Transposase and inactivated derivatives
AP3564_15535	COG1070	Carbohydrate kinase
AP3564_15540	COG1609	Transcriptional regulator
AP3564_15545	COG0310	cobalt ion transport
AP3564_15585	COG4565	transcriptional regulatory protein
AP3564_15590	COG3290	protein histidine kinase activity
AP3564_15605	COG3181	Tripartite tricarboxylate transporter family receptor
AP3564_15630	COG0439	Biotin carboxylase
AP3564_15635	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_15640	COG5016	pyruvate
AP3564_15640	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_15650	COG1414	Transcriptional regulator
AP3564_15655	COG1414	Transcriptional regulator
AP3564_15765	COG0174	glutamine synthetase
AP3564_15770	COG0789	Transcriptional regulator
AP3564_15775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AP3564_15780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AP3564_15785	COG0464	growth
AP3564_15790	COG1923	regulation of RNA biosynthetic process
AP3564_15795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AP3564_15800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AP3564_15805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AP3564_15815	COG4550	Control of competence regulator ComK, YlbF/YmcA
AP3564_15820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP3564_15825	COG1013	pyruvate-flavodoxin oxidoreductase activity
AP3564_15830	COG0674	pyruvate-flavodoxin oxidoreductase activity
AP3564_15830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AP3564_15835	COG2359	stage V sporulation protein S
AP3564_15840	COG1692	metallophosphoesterase
AP3564_15845	COG1418	mRNA catabolic process
AP3564_15850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AP3564_15855	COG1058	Belongs to the CinA family
AP3564_15855	COG1546	Belongs to the CinA family
AP3564_15860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AP3564_15865	COG1426	Protein conserved in bacteria
AP3564_15880	COG0300	oxidoreductase activity
AP3564_15885	COG0612	Peptidase, M16
AP3564_15890	COG0612	Peptidase, M16
AP3564_15905	COG4980	gas vesicle protein
AP3564_15905	COG1674	ftsk spoiiie
AP3564_15915	COG0740	serine-type endopeptidase activity
AP3564_15920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AP3564_15925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP3564_15930	COG0527	aspartate kinase activity
AP3564_15935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AP3564_15940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP3564_15945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_15950	COG1873	PFAM PRC-barrel domain
AP3564_15955	COG0612	Peptidase, M16
AP3564_15960	COG0726	polysaccharide deacetylase
AP3564_15965	COG1185	polyribonucleotide nucleotidyltransferase activity
AP3564_15970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AP3564_15975	COG0196	riboflavin kinase activity
AP3564_15980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AP3564_15990	COG1550	Protein conserved in bacteria
AP3564_15995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AP3564_16000	COG1358	cellular component organization or biogenesis
AP3564_16005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AP3564_16010	COG0195	Participates in both transcription termination and antitermination
AP3564_16015	COG0779	Required for maturation of 30S ribosomal subunits
AP3564_16020	COG2176	DNA-directed DNA polymerase activity
AP3564_16025	COG0442	prolyl-tRNA aminoacylation
AP3564_16030	COG0750	zinc metalloprotease
AP3564_16035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AP3564_16040	COG4589	Belongs to the CDS family
AP3564_16045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AP3564_16050	COG0233	cytoplasmic translational termination
AP3564_16055	COG0528	UMP kinase activity
AP3564_16060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AP3564_16065	COG0052	Belongs to the universal ribosomal protein uS2 family
AP3564_16075	COG1191	sigma factor activity
AP3564_16080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AP3564_16085	COG1776	CheC inhibitor of MCP methylation
AP3564_16090	COG0835	chemotaxis
AP3564_16095	COG2198	Histidine kinase
AP3564_16095	COG0643	Histidine kinase
AP3564_16100	COG2201	protein-glutamate methylesterase activity
AP3564_16105	COG0455	bacterial-type flagellum organization
AP3564_16110	COG1419	protein localization to endoplasmic reticulum
AP3564_16115	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AP3564_16120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AP3564_16125	COG1684	flagellar biosynthetic protein fliR
AP3564_16130	COG1987	bacterial-type flagellum assembly
AP3564_16135	COG1338	Plays a role in the flagellum-specific transport system
AP3564_16140	COG3190	flagellar
AP3564_16145	COG2201	protein-glutamate methylesterase activity
AP3564_16150	COG1776	CheC inhibitor of MCP methylation
AP3564_16150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_16155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_16160	COG1580	Controls the rotational direction of flagella during chemotaxis
AP3564_16165	COG1582	Flagellar protein (FlbD)
AP3564_16170	COG4786	Flagellar basal body rod
AP3564_16175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AP3564_16180	COG3144	bacterial-type flagellum assembly
AP3564_16190	COG2882	bacterial-type flagellum organization
AP3564_16195	COG1157	protein secretion by the type III secretion system
AP3564_16200	COG1317	bacterial-type flagellum organization
AP3564_16205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_16210	COG1766	The M ring may be actively involved in energy transduction
AP3564_16215	COG1677	Flagellar hook-basal body complex protein FliE
AP3564_16220	COG1558	bacterial-type flagellum-dependent cell motility
AP3564_16225	COG1815	bacterial-type flagellum-dependent cell motility
AP3564_16230	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AP3564_16235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AP3564_16240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AP3564_16245	COG4974	Belongs to the 'phage' integrase family
AP3564_16250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AP3564_16255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP3564_16260	COG0758	DNA mediated transformation
AP3564_16265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AP3564_16270	COG0045	succinate-CoA ligase (ADP-forming) activity
AP3564_16275	COG2257	FlhB HrpN YscU SpaS Family
AP3564_16285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AP3564_16300	COG0335	large ribosomal subunit rRNA binding
AP3564_16310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AP3564_16325	COG1837	Belongs to the UPF0109 family
AP3564_16330	COG0228	four-way junction DNA binding
AP3564_16335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AP3564_16340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AP3564_16345	COG0552	protein localization to endoplasmic reticulum
AP3564_16350	COG1196	nuclear chromosome segregation
AP3564_16355	COG0571	ribonuclease III activity
AP3564_16360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AP3564_16365	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_16370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AP3564_16375	COG0416	fatty acid biosynthetic process
AP3564_16380	COG1349	DNA-binding transcription factor activity
AP3564_16385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AP3564_16390	COG1461	Dihydroxyacetone kinase
AP3564_16395	COG1302	Protein conserved in bacteria
AP3564_16400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AP3564_16410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP3564_16420	COG0515	serine threonine protein kinase
AP3564_16420	COG2815	serine threonine protein kinase
AP3564_16425	COG0631	protein serine/threonine phosphatase activity
AP3564_16435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AP3564_16435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP3564_16445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AP3564_16450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP3564_16455	COG1758	RNA polymerase activity
AP3564_16460	COG0194	GDP metabolic process
AP3564_16465	COG2052	Domain of unknown function (DUF370)
AP3564_16470	COG1561	YicC-like family, N-terminal region
AP3564_16475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AP3564_16485	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AP3564_16490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP3564_16500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP3564_16505	COG0529	Catalyzes the synthesis of activated sulfate
AP3564_16510	COG2046	Belongs to the sulfate adenylyltransferase family
AP3564_16515	COG0175	sulfate reduction
AP3564_16520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AP3564_16525	COG0284	orotidine-5'-phosphate decarboxylase activity
AP3564_16530	COG0167	dihydroorotate dehydrogenase activity
AP3564_16535	COG0543	2 iron, 2 sulfur cluster binding
AP3564_16540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AP3564_16555	COG0540	Belongs to the ATCase OTCase family
AP3564_16565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AP3564_16570	COG0564	pseudouridine synthase activity
AP3564_16575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AP3564_16580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AP3564_16585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AP3564_16590	COG3599	regulation of cell shape
AP3564_16595	COG2302	S4 RNA-binding domain
AP3564_16600	COG0762	integral membrane protein
AP3564_16605	COG1799	cell septum assembly
AP3564_16610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AP3564_16620	COG1873	PFAM PRC-barrel domain
AP3564_16625	COG1191	sigma factor activity
AP3564_16630	COG1191	sigma factor activity
AP3564_16640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AP3564_16645	COG0849	cell division
AP3564_16650	COG3856	small basic protein
AP3564_16655	COG3879	Bacterial protein of unknown function (DUF881)
AP3564_16660	COG3879	Bacterial protein of unknown function (DUF881)
AP3564_16665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AP3564_16670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AP3564_16675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_16680	COG0772	Belongs to the SEDS family
AP3564_16685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AP3564_16690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_16695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AP3564_16700	COG0768	penicillin binding
AP3564_16710	COG4839	cell division protein FtsL
AP3564_16715	COG0275	rRNA processing
AP3564_16720	COG2001	Belongs to the MraZ family
AP3564_16725	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AP3564_16735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP3564_16740	COG0454	-acetyltransferase
AP3564_16755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AP3564_16760	COG1399	metal-binding, possibly nucleic acid-binding protein
AP3564_16765	COG1323	Belongs to the UPF0348 family
AP3564_16770	COG3480	Lon protease (S16) C-terminal proteolytic domain
AP3564_16775	COG1752	Esterase of the alpha-beta hydrolase superfamily
AP3564_16780	COG3314	Sporulation integral membrane protein YlbJ
AP3564_16785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AP3564_16790	COG0742	ribosomal rna small subunit methyltransferase
AP3564_16805	COG4471	UPF0298 protein
AP3564_16810	COG3679	Belongs to the UPF0342 family
AP3564_16835	COG2340	Cysteine-rich secretory protein family
AP3564_16850	COG3336	cytochrome c oxidase
AP3564_16855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AP3564_16860	COG1845	cytochrome c oxidase, subunit III
AP3564_16865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AP3564_16870	COG2010	Cytochrome c
AP3564_16870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AP3564_16875	COG0109	protoheme IX farnesyltransferase activity
AP3564_16880	COG1612	heme a metabolic process
AP3564_16885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AP3564_16890	COG1199	ATP-dependent helicase activity
AP3564_16895	COG0116	Belongs to the methyltransferase superfamily
AP3564_16915	COG3359	exonuclease
AP3564_16920	COG1205	dead DEAH box helicase
AP3564_16920	COG1111	helicase
AP3564_16955	COG3331	DNA recombination
AP3564_16960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_16960	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_16970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AP3564_16975	COG3935	DnaD domain protein
AP3564_16980	COG0017	Asparaginyl-tRNA synthetase
AP3564_16985	COG0436	Aminotransferase
AP3564_17005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AP3564_17010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AP3564_17025	COG0617	tRNA 3'-terminal CCA addition
AP3564_17030	COG0438	transferase activity, transferring glycosyl groups
AP3564_17035	COG1803	Methylglyoxal synthase
AP3564_17040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AP3564_17045	COG1694	Mazg nucleotide pyrophosphohydrolase
AP3564_17050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_17060	COG4347	Protein of unknown function (DUF1405)
AP3564_17075	COG1115	amino acid carrier protein
AP3564_17080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP3564_17080	COG2010	Cytochrome c
AP3564_17085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP3564_17110	COG5582	Belongs to the UPF0302 family
AP3564_17115	COG0457	Tetratricopeptide repeat
AP3564_17130	COG0287	Prephenate dehydrogenase
AP3564_17140	COG0159	tryptophan synthase activity
AP3564_17150	COG0135	phosphoribosylanthranilate isomerase activity
AP3564_17155	COG0134	indole-3-glycerol-phosphate synthase activity
AP3564_17160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP3564_17170	COG4401	Chorismate mutase type I
AP3564_17175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AP3564_17185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP3564_17190	COG0105	UTP biosynthetic process
AP3564_17195	COG0142	geranyltranstransferase activity
AP3564_17200	COG2226	methyltransferase
AP3564_17205	COG0142	geranyltranstransferase activity
AP3564_17215	COG0302	gtp cyclohydrolase
AP3564_17220	COG0776	regulation of translation
AP3564_17230	COG5337	Spore coat protein CotH
AP3564_17235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AP3564_17255	COG1160	GTP binding
AP3564_17275	COG0539	negative regulation of cytoplasmic translation
AP3564_17280	COG0204	Acyl-transferase
AP3564_17285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AP3564_17290	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AP3564_17295	COG2959	enzyme of heme biosynthesis
AP3564_17300	COG3773	Cell wall hydrolase
AP3564_17300	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_17305	COG2339	peptidase activity
AP3564_17315	COG0492	ferredoxin-NADP+ reductase activity
AP3564_17320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AP3564_17325	COG4862	establishment of competence for transformation
AP3564_17335	COG1388	LysM domain
AP3564_17340	COG1266	CAAX protease self-immunity
AP3564_17345	COG0514	ATP-dependent DNA helicase (RecQ)
AP3564_17350	COG4955	Helix-turn-helix domain
AP3564_17360	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AP3564_17370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP3564_17380	COG1595	DNA-templated transcription, initiation
AP3564_17385	COG2096	Adenosyltransferase
AP3564_17390	COG5002	protein histidine kinase activity
AP3564_17395	COG0745	RESPONSE REGULATOR receiver
AP3564_17400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP3564_17405	COG1333	cytochrome c biogenesis protein
AP3564_17410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_17415	COG1187	pseudouridine synthase activity
AP3564_17420	COG0700	Nucleoside recognition
AP3564_17425	COG2715	membrane protein required for spore maturation
AP3564_17430	COG1686	Belongs to the peptidase S11 family
AP3564_17435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AP3564_17440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AP3564_17445	COG1547	Domain of unknown function (DUF309)
AP3564_17450	COG0456	acetyltransferase
AP3564_17455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AP3564_17460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP3564_17460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP3564_17465	COG0307	riboflavin synthase, alpha
AP3564_17470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP3564_17470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP3564_17480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP3564_17485	COG4086	secreted protein
AP3564_17490	COG0019	diaminopimelate decarboxylase activity
AP3564_17495	COG0697	spore germination
AP3564_17500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_17525	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_17530	COG1686	Belongs to the peptidase S11 family
AP3564_17550	COG4974	Belongs to the 'phage' integrase family
AP3564_17560	COG0735	belongs to the Fur family
AP3564_17565	COG1300	Membrane
AP3564_17570	COG1379	DNA repair
AP3564_17575	COG0494	nUDIX hydrolase
AP3564_17585	COG0667	Aldo Keto reductase
AP3564_17595	COG0109	protoheme IX farnesyltransferase activity
AP3564_17615	COG0316	Belongs to the HesB IscA family
AP3564_17620	COG2226	methyltransferase
AP3564_17635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP3564_17645	COG0300	oxidoreductase activity
AP3564_17650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_17655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP3564_17660	COG1902	pentaerythritol trinitrate reductase activity
AP3564_17675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AP3564_17680	COG1254	Belongs to the acylphosphatase family
AP3564_17685	COG4214	carbohydrate transport
AP3564_17700	COG1657	PFAM Prenyltransferase squalene oxidase
AP3564_17735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AP3564_17740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP3564_17745	COG0493	'glutamate synthase
AP3564_17750	COG0067	glutamate synthase
AP3564_17750	COG0069	glutamate synthase activity
AP3564_17750	COG0070	glutamate synthase
AP3564_17755	COG0583	DNA-binding transcription factor activity
AP3564_17760	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP3564_17765	COG4129	membrane
AP3564_17775	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_17780	COG0022	dehydrogenase e1 component
AP3564_17785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_17790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP3564_17800	COG0745	RESPONSE REGULATOR receiver
AP3564_17805	COG0750	zinc metalloprotease
AP3564_17810	COG0497	DNA recombination
AP3564_17815	COG1438	arginine binding
AP3564_17820	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AP3564_17825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AP3564_17835	COG0142	geranyltranstransferase activity
AP3564_17840	COG1722	exodeoxyribonuclease VII activity
AP3564_17845	COG1570	exodeoxyribonuclease VII activity
AP3564_17850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AP3564_17860	COG1302	Protein conserved in bacteria
AP3564_17865	COG0439	Biotin carboxylase
AP3564_17870	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_17910	COG3854	ATPases associated with a variety of cellular activities
AP3564_17915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AP3564_17920	COG0006	proline dipeptidase activity
AP3564_17935	COG3872	metal-dependent enzyme
AP3564_17945	COG1752	Esterase of the alpha-beta hydrolase superfamily
AP3564_17965	COG0662	Cupin 2, conserved barrel domain protein
AP3564_18005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_18010	COG0095	Lipoate-protein ligase
AP3564_18015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_18025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AP3564_18030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_18035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP3564_18070	COG4537	Required for transformation and DNA binding
AP3564_18075	COG1459	type II secretion system
AP3564_18080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP3564_18100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_18120	COG1368	sulfuric ester hydrolase activity
AP3564_18125	COG1940	carbohydrate kinase activity
AP3564_18130	COG4483	Protein conserved in bacteria
AP3564_18135	COG0457	Tetratricopeptide repeat
AP3564_18135	COG0705	Rhomboid family
AP3564_18145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AP3564_18150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AP3564_18160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP3564_18165	COG0704	Plays a role in the regulation of phosphate uptake
AP3564_18170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AP3564_18175	COG0581	inorganic phosphate transmembrane transporter activity
AP3564_18180	COG0573	inorganic phosphate transmembrane transporter activity
AP3564_18185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AP3564_18190	COG0477	Major facilitator Superfamily
AP3564_18205	COG2839	Protein conserved in bacteria
AP3564_18210	COG1283	sodium-dependent phosphate transmembrane transporter activity
AP3564_18215	COG5521	maltodextrose utilization protein MalA
AP3564_18220	COG0840	transmembrane signaling receptor activity
AP3564_18225	COG2814	Major facilitator Superfamily
AP3564_18230	COG1388	LysM domain
AP3564_18235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AP3564_18245	COG4709	membrane
AP3564_18250	COG0735	belongs to the Fur family
AP3564_18255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_18260	COG1121	(ABC) transporter
AP3564_18265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_18275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AP3564_18280	COG0513	Belongs to the DEAD box helicase family
AP3564_18290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AP3564_18295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AP3564_18300	COG2384	SAM-dependent methyltransferase
AP3564_18305	COG2010	Cytochrome c
AP3564_18310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP3564_18315	COG0358	DNA primase activity
AP3564_18320	COG1671	Belongs to the UPF0178 family
AP3564_18325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AP3564_18330	COG0517	IMP dehydrogenase activity
AP3564_18335	COG0751	glycine-tRNA ligase activity
AP3564_18340	COG0752	glycyl-tRNA synthetase alpha subunit
AP3564_18345	COG1381	Involved in DNA repair and RecF pathway recombination
AP3564_18355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AP3564_18360	COG0295	cytidine deaminase activity
AP3564_18365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AP3564_18375	COG1480	7TM receptor with intracellular HD hydrolase
AP3564_18380	COG1702	phosphate starvation-inducible protein PhoH
AP3564_18400	COG4864	UPF0365 protein
AP3564_18405	COG1030	water channel activity
AP3564_18410	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AP3564_18415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_18420	COG0726	polysaccharide deacetylase
AP3564_18425	COG1610	YqeY-like protein
AP3564_18430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AP3564_18435	COG1283	sodium-dependent phosphate transmembrane transporter activity
AP3564_18440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP3564_18445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP3564_18450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AP3564_18455	COG2264	protein methyltransferase activity
AP3564_18460	COG0484	heat shock protein binding
AP3564_18465	COG0443	Heat shock 70 kDa protein
AP3564_18475	COG1420	regulation of RNA biosynthetic process
AP3564_18480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP3564_18485	COG0481	GTPase activity
AP3564_18495	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_18505	COG0268	Binds directly to 16S ribosomal RNA
AP3564_18510	COG1466	dna polymerase III delta subunit
AP3564_18520	COG0658	competence protein
AP3564_18520	COG2333	competence protein COMEC
AP3564_18525	COG2131	deaminase
AP3564_18530	COG1555	photosystem II stabilization
AP3564_18530	COG1596	polysaccharide export
AP3564_18535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP3564_18540	COG2226	methyltransferase
AP3564_18545	COG0799	negative regulation of ribosome biogenesis
AP3564_18550	COG1713	HD superfamily hydrolase involved in NAD metabolism
AP3564_18555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AP3564_18560	COG1534	Rna-binding protein
AP3564_18570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AP3564_18575	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AP3564_18595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AP3564_18605	COG0768	penicillin binding
AP3564_18610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP3564_18630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP3564_18635	COG3906	Belongs to the UPF0473 family
AP3564_18640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AP3564_18650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AP3564_18655	COG0628	permease
AP3564_18665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AP3564_18675	COG0482	sulfurtransferase activity
AP3564_18680	COG1104	cysteine desulfurase activity
AP3564_18685	COG1959	2 iron, 2 sulfur cluster binding
AP3564_18690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AP3564_18695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AP3564_18705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AP3564_18710	COG0124	histidyl-tRNA synthetase
AP3564_18715	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_18715	COG3103	Sh3 type 3 domain protein
AP3564_18715	COG4991	sh3 domain protein
AP3564_18720	COG1490	D-aminoacyl-tRNA deacylase activity
AP3564_18725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AP3564_18730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP3564_18735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AP3564_18735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AP3564_18740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP3564_18740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP3564_18750	COG2244	polysaccharide biosynthetic process
AP3564_18760	COG1862	Preprotein translocase
AP3564_18765	COG0343	queuine tRNA-ribosyltransferase activity
AP3564_18770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AP3564_18780	COG2255	four-way junction helicase activity
AP3564_18785	COG0632	four-way junction helicase activity
AP3564_18795	COG0217	transcriptional regulatory protein
AP3564_18805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AP3564_18810	COG3344	reverse transcriptase
AP3564_18815	COG1388	LysM domain
AP3564_18820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AP3564_18825	COG0157	Belongs to the NadC ModD family
AP3564_18835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AP3564_18840	COG1104	cysteine desulfurase activity
AP3564_18845	COG1827	regulation of RNA biosynthetic process
AP3564_18850	COG0077	Prephenate dehydratase
AP3564_18855	COG4492	Belongs to the UPF0735 family
AP3564_18860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AP3564_18865	COG3290	protein histidine kinase activity
AP3564_18870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AP3564_18875	COG2868	ribosomal protein
AP3564_18880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AP3564_18885	COG1530	ribonuclease E activity
AP3564_18890	COG1994	Peptidase M50
AP3564_18895	COG0739	heme binding
AP3564_18900	COG1914	H( )-stimulated, divalent metal cation uptake system
AP3564_18905	COG0778	Nitroreductase
AP3564_18915	COG2894	cell division
AP3564_18920	COG0850	regulation of cytokinetic process
AP3564_18925	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AP3564_18930	COG1792	Involved in formation and maintenance of cell shape
AP3564_18935	COG1077	Cell shape determining protein MreB Mrl
AP3564_18940	COG2003	Belongs to the UPF0758 family
AP3564_18955	COG0285	dihydrofolate synthase activity
AP3564_18975	COG1388	LysM domain
AP3564_18980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP3564_18985	COG0113	porphobilinogen synthase activity
AP3564_18990	COG1587	Uroporphyrinogen-III synthase
AP3564_18995	COG0181	hydroxymethylbilane synthase activity
AP3564_19000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP3564_19015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AP3564_19020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AP3564_19025	COG1067	ATP-dependent peptidase activity
AP3564_19025	COG0470	DNA polymerase III
AP3564_19030	COG3344	reverse transcriptase
AP3564_19035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AP3564_19040	COG0544	peptidyl-prolyl cis-trans isomerase activity
AP3564_19045	COG0457	Tetratricopeptide repeat
AP3564_19045	COG1477	protein flavinylation
AP3564_19050	COG0066	3-isopropylmalate dehydratase activity
AP3564_19055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AP3564_19060	COG0473	3-isopropylmalate dehydrogenase activity
AP3564_19065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_19070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AP3564_19075	COG0440	acetolactate synthase activity
AP3564_19080	COG0028	Belongs to the TPP enzyme family
AP3564_19085	COG2315	Protein conserved in bacteria
AP3564_19095	COG0622	Phosphoesterase
AP3564_19100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AP3564_19105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AP3564_19110	COG5401	PFAM Sporulation and spore germination
AP3564_19115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AP3564_19120	COG1846	Transcriptional regulator
AP3564_19125	COG2197	response regulator
AP3564_19130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AP3564_19135	COG1053	succinate dehydrogenase
AP3564_19140	COG2009	succinate dehydrogenase
AP3564_19145	COG1719	4-vinyl reductase, 4VR
AP3564_19150	COG0322	excinuclease ABC activity
AP3564_19155	COG3118	belongs to the thioredoxin family
AP3564_19160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AP3564_19165	COG2086	electron transfer activity
AP3564_19170	COG1309	transcriptional regulator
AP3564_19175	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_19180	COG3766	membrane
AP3564_19185	COG1193	negative regulation of DNA recombination
AP3564_19200	COG1286	toxin biosynthetic process
AP3564_19205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AP3564_19215	COG0072	phenylalanine-tRNA ligase activity
AP3564_19215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP3564_19220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AP3564_19230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_19240	COG1363	Peptidase, m42
AP3564_19255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AP3564_19260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AP3564_19275	COG5146	pantothenate kinase activity
AP3564_19280	COG3344	reverse transcriptase
AP3564_19285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AP3564_19295	COG1484	DNA-dependent DNA replication
AP3564_19300	COG3611	Membrane attachment protein
AP3564_19305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AP3564_19310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AP3564_19315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP3564_19325	COG1971	Probably functions as a manganese efflux pump
AP3564_19330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AP3564_19335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP3564_19335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP3564_19340	COG0330	HflC and HflK could
AP3564_19345	COG0330	HflC and HflK could
AP3564_19350	COG5002	protein histidine kinase activity
AP3564_19355	COG0745	RESPONSE REGULATOR receiver
AP3564_19365	COG0538	isocitrate dehydrogenase activity
AP3564_19370	COG0372	Belongs to the citrate synthase family
AP3564_19375	COG3030	protein affecting phage T7 exclusion by the F plasmid
AP3564_19385	COG0205	6-phosphofructokinase activity
AP3564_19390	COG0825	malonyl-CoA metabolic process
AP3564_19395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AP3564_19400	COG0281	malic enzyme
AP3564_19405	COG0587	DNA-directed DNA polymerase activity
AP3564_19420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AP3564_19430	COG4109	DRTGG domain
AP3564_19435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AP3564_19440	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_19445	COG0165	Argininosuccinate lyase
AP3564_19450	COG0137	argininosuccinate synthase activity
AP3564_19470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AP3564_19475	COG0827	DNA restriction-modification system
AP3564_19480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AP3564_19485	COG3874	Sporulation protein YtfJ
AP3564_19495	COG1714	RDD family
AP3564_19500	COG0616	signal peptide processing
AP3564_19505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AP3564_19515	COG0301	tRNA thio-modification
AP3564_19520	COG1104	cysteine desulfurase activity
AP3564_19525	COG3842	ATPase activity
AP3564_19530	COG0656	L-ascorbic acid biosynthetic process
AP3564_19535	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AP3564_19540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AP3564_19545	COG1309	transcriptional regulator
AP3564_19550	COG1956	GAF domain-containing protein
AP3564_19555	COG2199	diguanylate cyclase activity
AP3564_19555	COG2203	Gaf domain
AP3564_19560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AP3564_19635	COG1830	Aldolase
AP3564_19640	COG1063	alcohol dehydrogenase
AP3564_19650	COG1737	Transcriptional regulator