locus-tag	class	description
APP_00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
APP_00030	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
APP_00040	ENOG410848D	S4 domain protein YaaA
APP_00050	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
APP_00060	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APP_00070	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APP_00080	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
APP_00100	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
APP_00120	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
APP_00130	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
APP_00140	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
APP_00150	ENOG4105D5U	fad dependent oxidoreductase
APP_00160	ENOG4105VRS	hydrolase family 18
APP_00170	ENOG4108Z6B	deaminase
APP_00180	ENOG4105C6E	dna polymerase iii
APP_00190	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
APP_00200	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
APP_00220	ENOG41067KS	pro-sigma K processing
APP_00250	ENOG4105CXN	decarboxylase
APP_00260	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
APP_00270	ENOG4105X0R	protein from nitrogen regulatory protein P-II
APP_00280	ENOG4105XVJ	Protein of unknown function (DUF327)
APP_00290	ENOG4105FA2	dna polymerase iii
APP_00300	ENOG4105MA4	psp1 domain protein
APP_00310	ENOG41063V3	Involved in initiation control of chromosome replication (By similarity)
APP_00320	ENOG41060K3	Methyltransferase
APP_00330	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
APP_00340	ENOG4105KRN	Transcriptional regulator, abrb family
APP_00360	ENOG4105F8V	Hydrolase, tatD family
APP_00370	ENOG41069ER	domain protein
APP_00390	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
APP_00400	ENOG4105XFA	sporulation peptidase YabG
APP_00410	ENOG4105W42	Veg protein
APP_00420	ENOG4105XEW	small acid-soluble spore protein
APP_00430	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
APP_00440	ENOG4105DFT	pur operon repressor
APP_00450	ENOG4105KME	endoribonuclease L-psp
APP_00470	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
APP_00480	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
APP_00490	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
APP_00500	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
APP_00520	ENOG4108JA2	transcriptioN-repair coupling factor
APP_00530	ENOG4108M14	stage v sporulation protein t
APP_00550	ENOG4108IY2	MazG family
APP_00560	ENOG41082I2	s4 domain protein
APP_00570	ENOG4105VYY	sporulation protein yabp
APP_00590	ENOG41060GV	RNA binding s1 domain protein
APP_00630	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
APP_00640	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
APP_00650	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APP_00660	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
APP_00670	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
APP_00680	ENOG4107U48	ppic-type peptidyL-prolyl cis-trans isomerase
APP_00690	ENOG4105C6T	cysteine synthase
APP_00700	ENOG4105CRQ	synthase (Component I)
APP_00710	ENOG4105DDQ	anthranilate synthase
APP_00720	ENOG41082R7	4-amino-4-deoxychorismate lyase EC 4.1.3.38
APP_00730	ENOG4105EEI	dihydropteroate synthase
APP_00740	ENOG4105KRF	dihydroneopterin aldolase
APP_00750	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APP_00770	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
APP_00780	ENOG4105CRK	lysyL-tRNA synthetase
APP_00860	ENOG4105DA5	(ABC) transporter
APP_00890	ENOG4106A3R	peptidase
APP_00950	ENOG4105CZX	twitching motility protein
APP_00960	ENOG4107QHF	type ii secretion system protein e
APP_01010	ENOG4105KT7	mgtC SapB transporter
APP_01030	ENOG4108Z0C	Uvrb UvrC protein
APP_01040	ENOG41066A3	ATP guanido phosphotransferase
APP_01060	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
APP_01070	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
APP_01080	ENOG4105CTP	PilT protein domain protein
APP_01090	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
APP_01100	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
APP_01110	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
APP_01120	ENOG4105D7W	serine acetyltransferase
APP_01130	ENOG4105C8N	cysteinyl-tRNA synthetase
APP_01140	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APP_01150	ENOG4105C2N	RNA methyltransferase TrmH family group 3
APP_01160	ENOG4105M0M	Tetracycline resistance protein
APP_01170	ENOG4105QIV	RNA polymerase
APP_01190	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
APP_01210	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
APP_01220	ENOG4108VZM	50s ribosomal protein L10
APP_01230	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
APP_01240	ENOG4107Y49	methyltransferase
APP_01250	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APP_01260	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APP_01270	ENOG4105XPM	ribosomal protein
APP_01280	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
APP_01290	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
APP_01300	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
APP_01310	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
APP_01320	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
APP_01330	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
APP_01340	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
APP_01350	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
APP_01360	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APP_01370	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
APP_01380	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
APP_01390	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
APP_01410	ENOG41082SA	50s ribosomal protein l29
APP_01420	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
APP_01430	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
APP_01450	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APP_01460	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
APP_01470	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
APP_01480	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
APP_01490	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
APP_01500	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
APP_01520	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
APP_01530	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
APP_01540	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
APP_01550	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
APP_01570	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
APP_01580	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APP_01590	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
APP_01610	ENOG4108ZT0	50S ribosomal protein l17
APP_01620	ENOG4108JJB	ABC transporter
APP_01630	ENOG4108JJB	ABC transporter
APP_01640	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
APP_01650	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
APP_01660	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
APP_01670	ENOG4108UJD	30S ribosomal protein S9
APP_01710	ENOG4105D1F	ATP-binding protein
APP_01740	ENOG4108NMV	polysaccharide deacetylase
APP_01770	ENOG4105EMN	RNA polymerase sigma factor
APP_01790	ENOG4105C8B	TIGR00159 family
APP_01800	ENOG4107U5W	ybbr family
APP_01810	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
APP_01820	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
APP_01850	ENOG4105C0X	amino acid
APP_01880	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
APP_01910	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APP_01920	ENOG4105CE4	GlcNAc 6-P deacetylase
APP_01930	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
APP_02050	ENOG4105D5G	Transposase
APP_02070	ENOG4105C37	(CBS) domain
APP_02130	ENOG4105FBW	Monooxygenase
APP_02140	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
APP_02200	ENOG410804X	Transcriptional regulator
APP_02220	ENOG41090UW	PTS System
APP_02230	ENOG4105DT3	PTS system, galactitol-specific IIc component
APP_02240	ENOG4107WTH	Galactitol-1-phosphate dehydrogenase
APP_02250	ENOG4105D2M	Aldolase
APP_02260	ENOG4105C85	amino acid
APP_02280	ENOG4105EA8	2-Nitropropane dioxygenase
APP_02310	ENOG4105CQB	FAD linked oxidase domain protein
APP_02320	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APP_02330	ENOG4105CQB	FAD linked oxidase domain protein
APP_02340	ENOG4105C82	Malate synthase
APP_02360	ENOG4105J4Q	Transcriptional regulator
APP_02370	ENOG4105DAA	L-lactate
APP_02380	ENOG4105XTG	Pfam:DUF156
APP_02400	ENOG4105EAB	amino acid AbC transporter
APP_02410	ENOG4105E5Q	amino acid AbC transporter
APP_02420	ENOG4105CDA	abc transporter atp-binding protein
APP_02460	ENOG410814C	multidrug resistance protein
APP_02470	ENOG4107E54	Small Multidrug Resistance protein
APP_02490	ENOG4105DKG	l-rhamnose isomerase
APP_02500	ENOG4105CMG	Carbohydrate kinase
APP_02510	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
APP_02530	ENOG4105C2F	Histidine kinase
APP_02540	ENOG41075H3	AraC family transcriptional regulator
APP_02550	ENOG4105DJV	ribulose-phosphate 3-epimerase
APP_02560	ENOG4108RVA	ribokinase
APP_02570	ENOG4105C2J	ABC transporter
APP_02580	ENOG4105CNN	ABC, transporter
APP_02600	ENOG4105D4B	ABC, transporter
APP_02610	ENOG4105DET	Rhamnulokinase
APP_02640	ENOG4108WUZ	(ABC) transporter
APP_02650	ENOG41066N6	Abortive infection protein
APP_02660	ENOG4107ZBH	radical SAM domain protein
APP_02770	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
APP_02820	ENOG4105FBW	Monooxygenase
APP_02840	ENOG4107T8P	acyl-Coa dehydrogenase
APP_02850	ENOG4108UZX	fmn reductase
APP_02880	ENOG4108KC1	acyl-Coa dehydrogenase
APP_02890	ENOG4105FDT	acyl-CoA dehydrogenase
APP_02910	ENOG4108UMI	ABC transporter, permease
APP_02920	ENOG4105D01	(LipO)protein
APP_02940	ENOG4105CPC	Aldo Keto reductase
APP_02950	ENOG4108KC1	acyl-Coa dehydrogenase
APP_02960	ENOG4105C1G	acyl-Coa dehydrogenase
APP_02970	ENOG4105DEN	Luciferase family
APP_02980	ENOG4105NBF	ammecr1 domain protein
APP_03010	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
APP_03050	ENOG41069M3	Transcriptional regulator
APP_03070	ENOG4105ECY	inositol monophosphatase
APP_03080	ENOG41073TP	transcriptional regulator
APP_03090	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
APP_03100	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
APP_03140	ENOG4105DRP	amino acid AbC transporter
APP_03150	ENOG4105EAD	ABC transporter
APP_03220	ENOG4107RKG	DJ-1/PfpI family
APP_03230	ENOG4105DUX	Transporter
APP_03250	ENOG4105DUX	Transporter
APP_03260	ENOG4105DEN	Luciferase family
APP_03280	ENOG4105DJ2	Major Facilitator Superfamily
APP_03330	ENOG4107WD8	ABC transporter, permease
APP_03340	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APP_03350	ENOG4105BZU	Histidine kinase
APP_03360	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
APP_03370	ENOG4108Q5U	germination protein, ger(x)c family
APP_03390	ENOG4105CBC	glutamate synthase
APP_03410	ENOG4105CM2	brancheD-chain amino acid aminotransferase
APP_03430	ENOG4105SZ6	Thioredoxin
APP_03440	ENOG4105CPF	Cell wall formation (By similarity)
APP_03450	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
APP_03460	ENOG4105C1J	atp-dependent rna helicase
APP_03470	ENOG410905X	membrane-flanked domain protein
APP_03480	ENOG4105CKV	Membrane
APP_03500	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
APP_03510	ENOG4108SGW	outer membrane lipoprotein-sorting protein-like protein
APP_03540	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
APP_03550	ENOG4107MMM	Anti-sigma-factor antagonist
APP_03560	ENOG4105FUA	antagonist
APP_03570	ENOG4105QD0	anti-sigma regulatory factor serine threonine protein kinase
APP_03580	ENOG4107SGM	protein serine threonine phosphatase
APP_03590	ENOG4105WN5	stage II sporulation protein
APP_03600	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
APP_03620	ENOG41064BQ	Phosphatase
APP_03650	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
APP_03660	ENOG4105K8N	protein family UPF0079, ATPase
APP_03670	ENOG41072GX	Peptidase M22 Glycoprotease
APP_03680	ENOG410801F	ribosomal-protein-alanine acetyltransferase
APP_03690	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APP_03700	ENOG4105C5H	ABC transporter
APP_03710	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
APP_03720	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
APP_03730	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
APP_03750	ENOG4108TYN	CAAX amino terminal protease family protein
APP_03760	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
APP_03770	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
APP_03780	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APP_03950	ENOG4105C19	ABC transporter
APP_03980	ENOG4105NX3	Membrane
APP_04010	ENOG4105E5H	Transposase
APP_04020	ENOG4105VMP	Transcriptional regulator
APP_04090	ENOG4105D0M	Protease HtpX homolog
APP_04190	ENOG4105C26	Dehydrogenase
APP_04200	ENOG4105DH8	myo-inositol catabolism
APP_04210	ENOG4105EDK	PfkB domain protein
APP_04220	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
APP_04230	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
APP_04240	ENOG4107QNK	)-transporter
APP_04250	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
APP_04260	ENOG4105F0H	myo-inositol catabolism protein
APP_04270	ENOG4107VG4	Xylose isomerase domain protein TIM barrel
APP_04280	ENOG4105D2N	Aldolase
APP_04300	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
APP_04310	ENOG4105CPC	Aldo Keto reductase
APP_04330	ENOG4105CIB	oxidoreductase Domain protein
APP_04350	ENOG4105C2J	ABC transporter
APP_04360	ENOG4105CNN	ABC, transporter
APP_04390	ENOG4105D2N	Aldolase
APP_04430	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APP_04440	ENOG4105CQB	FAD linked oxidase domain protein
APP_04450	ENOG4105JXH	GntR family transcriptional regulator
APP_04470	ENOG4105C26	Dehydrogenase
APP_04500	ENOG4105C45	hydrogenase expression formation protein (HypE)
APP_04510	ENOG4105CQS	hydrogenase expression formation protein HypD
APP_04590	ENOG4105DPX	Hydrogenase, large subunit
APP_04630	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
APP_04700	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
APP_04710	ENOG4105FD8	phosphonate metabolism protein PhnM
APP_04730	ENOG4105HRV	phosphonate c-p lyase system protein phnl
APP_04750	ENOG4105D5T	phosphonate abc transporter
APP_04770	ENOG4105S7S	phosphonate abc transporter
APP_04780	ENOG4105DB7	PHP domain protein
APP_04810	ENOG4105DA5	(ABC) transporter
APP_04870	ENOG4105DA5	(ABC) transporter
APP_04900	ENOG4105FDR	Membrane
APP_04940	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
APP_05000	ENOG4107RUY	(E1 component), alpha subunit
APP_05020	ENOG4107QKR	Dehydrogenase
APP_05030	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APP_05040	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
APP_05060	ENOG4105DSE	periplasmic solute binding protein
APP_05070	ENOG4105DIK	(ABC) transporter
APP_05080	ENOG4105CC5	ABC transporter
APP_05090	ENOG4105CC5	ABC transporter
APP_05100	ENOG4105KST	dependent repressor
APP_05140	ENOG4105BZ4	penicillin-binding protein
APP_05160	ENOG4105DM4	PTS System
APP_05170	ENOG4105C8I	hydrolase, family 38
APP_05180	ENOG4105BZW	Glycerate kinase
APP_05190	ENOG4105DG6	mannose-6-phosphate isomerase
APP_05240	ENOG410787A	Pts system, glucitol sorbitol-specific
APP_05250	ENOG4105DZY	Pts system, glucitol sorbitol-specific
APP_05260	ENOG4105VI0	Pts system, glucitol sorbitol-specific
APP_05270	ENOG4107RHR	regulatoR
APP_05280	ENOG4107RUY	(E1 component), alpha subunit
APP_05290	ENOG4105CPP	Dehydrogenase, E1 component
APP_05300	ENOG4105C7S	Dehydrogenase
APP_05320	ENOG4107RHR	regulatoR
APP_05330	ENOG41082GB	PTS system galactitol-specific transporter subunit IIA
APP_05340	ENOG4105K18	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
APP_05350	ENOG4105DT3	PTS system, galactitol-specific IIc component
APP_05360	ENOG4108MRH	transcriptional regulatory protein
APP_05370	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
APP_05380	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
APP_05390	ENOG4107QJT	sodium dicarboxylate symporter
APP_05400	ENOG4105DG6	mannose-6-phosphate isomerase
APP_05430	ENOG4108KGH	TRANSCRIPTIONal
APP_05450	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
APP_05460	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
APP_05480	ENOG4107SJB	teichoic acid biosynthesis
APP_05500	ENOG4105EY8	ABC transporter
APP_05550	ENOG4105CJR	Integral membrane protein (MviN
APP_05570	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
APP_05590	ENOG4105W2C	Glycosyl transferase
APP_05600	ENOG4105ESV	Glycosyl transferase, family 4
APP_05610	ENOG4108KGH	TRANSCRIPTIONal
APP_05620	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
APP_05630	ENOG4105BZU	Histidine kinase
APP_05640	ENOG4105WH1	Two component transcriptional regulator luxr family
APP_05680	ENOG41081UC	Inherit from COG: Competence protein
APP_05690	ENOG4105RU3	
APP_05720	ENOG4105E1Q	flagellar hook-associated protein
APP_05730	ENOG4105DTJ	flagellar hook-associated protein
APP_05740	ENOG4105MKD	
APP_05750	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
APP_05760	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
APP_05770	ENOG4105I03	Flagellin
APP_05780	ENOG4105EKQ	RNA-directed DNA polymerase
APP_05810	ENOG4108IAJ	Nad-dependent epimerase dehydratase
APP_05820	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
APP_05860	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
APP_05870	ENOG4107YEI	lmbE family
APP_05880	ENOG4105D2T	synthase
APP_05960	ENOG4108QBF	Transcriptional regulator
APP_05980	ENOG4105DQ6	Transposase
APP_06000	ENOG4105T1M	mycothiol conjugate amidase mca
APP_06010	ENOG4105JSC	dimethylmenaquinone methyltransferase
APP_06030	ENOG4105D2S	major facilitator superfamily
APP_06070	ENOG41067SE	Tetr family transcriptional regulator
APP_06110	ENOG41069ER	domain protein
APP_06130	ENOG4106I4J	membrane
APP_06140	ENOG4108JUB	Transcriptional regulator
APP_06150	ENOG4105C0A	alcohol dehydrogenase
APP_06170	ENOG4105C26	Dehydrogenase
APP_06190	ENOG4105D94	Major Facilitator Superfamily
APP_06210	ENOG4105CID	antiterminator
APP_06230	ENOG4105CID	antiterminator
APP_06240	ENOG4105CS2	ec 3.2.1.21
APP_06250	ENOG4105CS2	ec 3.2.1.21
APP_06260	ENOG4105C5Y	PTS System
APP_06270	ENOG4107Z6I	Thiamine biosynthesis protein
APP_06280	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APP_06300	ENOG4105EC8	Methyl-accepting chemotaxis
APP_06320	ENOG4105EIG	urea carboxylase-associated protein 1
APP_06330	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APP_06390	ENOG4108IUX	(ABC) transporter
APP_06400	ENOG4105RHA	ABC transporter, permease
APP_06410	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_06430	ENOG4105E98	transcriptional regulator DeoR family
APP_06440	ENOG4105NWF	RbsD or FucU transport
APP_06450	ENOG4105CMG	Carbohydrate kinase
APP_06460	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
APP_06470	ENOG4105C2J	ABC transporter
APP_06480	ENOG4105CNN	ABC, transporter
APP_06500	ENOG4107W7X	Aldolase
APP_06510	ENOG4105DET	Rhamnulokinase
APP_06530	ENOG4105EF1	ribulokinase
APP_06550	ENOG4108IIH	CoA-transferase subunit B
APP_06560	ENOG4105D6N	CoA-transferase, subunit a
APP_06570	ENOG4105CMU	LysR family (Transcriptional regulator
APP_06580	ENOG4107RID	5-oxoprolinase (ATP-hydrolyzing)
APP_06590	ENOG4107TYC	hydantoinase B oxoprolinase
APP_06600	ENOG4105HKX	acetone carboxylase, gamma subunit
APP_06630	ENOG4105BZU	Histidine kinase
APP_06640	ENOG4105WH1	Two component transcriptional regulator luxr family
APP_06650	ENOG4105CJ1	ABC, transporter
APP_06680	ENOG4105BZ1	(ABC) transporter
APP_06700	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APP_06730	ENOG4108UVJ	appr-1-p processing domain protein
APP_06740	ENOG4108VEN	abc transporter atp-binding protein
APP_06750	ENOG4108Z66	YbaK ebsC protein
APP_06780	ENOG4105X1N	Glycosyl transferase family 8
APP_06790	ENOG4105G9B	Transcriptional regulator
APP_06800	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
APP_06810	ENOG4105E39	Enoyl-CoA hydratase
APP_06820	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_06850	ENOG4105C1G	acyl-Coa dehydrogenase
APP_06890	ENOG4105DZS	Phenylacetate-CoA ligase
APP_06920	ENOG4105ERH	Fumarylacetoacetate hydrolase
APP_06970	ENOG41083S7	flagellar protein FlaG
APP_06980	ENOG4107RT6	flagellar hook-associated
APP_06990	ENOG4105MQ3	flagellar protein FliS
APP_07010	ENOG4105MS2	ribosomal subunit Interface protein
APP_07020	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
APP_07030	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
APP_07050	ENOG4105CAK	Cell division ATP-binding protein ftsE
APP_07060	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
APP_07070	ENOG4105DR5	peptidase
APP_07080	ENOG4105CN1	protease
APP_07100	ENOG4105H3G	oxidoreductase
APP_07110	ENOG4105PGM	cation diffusion facilitator family transporter
APP_07120	ENOG4105KTU	Transcriptional regulator, arsr family
APP_07160	ENOG4105EVU	fructokinase
APP_07180	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
APP_07190	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
APP_07210	ENOG4105FDT	acyl-CoA dehydrogenase
APP_07220	ENOG4105CDA	abc transporter atp-binding protein
APP_07230	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
APP_07280	ENOG41086DT	Membrane protein of unknown function
APP_07290	ENOG41088CQ	domain protein
APP_07300	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
APP_07320	ENOG4105HKU	nucleoside recognition domain-containing protein
APP_07330	ENOG4107XGZ	Hydrolase
APP_07340	ENOG4108S4C	acetyltransferase
APP_07350	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
APP_07360	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
APP_07370	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
APP_07380	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
APP_07390	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
APP_07400	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
APP_07410	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
APP_07420	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
APP_07440	ENOG4105C3M	thioredoxin reductase
APP_07450	ENOG4108Z4K	mutator MutT protein
APP_07460	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
APP_07470	ENOG4105CHW	UPF0052 protein
APP_07480	ENOG4105CIE	May be required for sporulation (By similarity)
APP_07490	ENOG4105KRI	phosphocarrier protein (HPr
APP_07500	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
APP_07520	ENOG4105DY9	regulatoR
APP_07530	ENOG4105CYC	Transferase
APP_07540	ENOG4105BZW	Glycerate kinase
APP_07550	ENOG4106KNT	transcriptional regulator
APP_07560	ENOG4105F8D	glycoside hydrolase family 4
APP_07600	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
APP_07610	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
APP_07650	ENOG4105E5H	Transposase
APP_07700	ENOG410695F	Crispr-associated protein, Csm1 family
APP_07720	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
APP_07740	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
APP_07790	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
APP_07810	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
APP_07840	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_07880	ENOG4105BZA	Phosphoglycerate kinase
APP_07890	ENOG4105CP7	Triose-phosphate isomerase
APP_07910	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
APP_07920	ENOG4105G7B	Protein of unknown function (DUF2992)
APP_07930	ENOG4105XZU	Preprotein translocase, subunit SecG
APP_07950	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
APP_07960	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
APP_07990	ENOG4107RBB	ABC transporter, permease
APP_08030	ENOG4105E2Y	ABC, transporter
APP_08060	ENOG4105CIY	formyltetrahydrofolate deformylase
APP_08070	ENOG4105V75	Transcriptional regulator
APP_08080	ENOG4105C9Q	fumarate hydratase class II
APP_08100	ENOG4108MES	Periplasmic binding protein
APP_08110	ENOG4105DQ5	transport system permease protein
APP_08120	ENOG4108IHU	transport system permease protein
APP_08130	ENOG4105E0A	ABC, transporter
APP_08190	ENOG4105CHU	acetyl-coa acetyltransferase
APP_08200	ENOG4105C1G	acyl-Coa dehydrogenase
APP_08210	ENOG41080E8	Transcriptional regulator, Spx MgsR family
APP_08220	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
APP_08260	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
APP_08270	ENOG4108UMI	ABC transporter, permease
APP_08280	ENOG4105D01	(LipO)protein
APP_08300	ENOG4105C3K	feS assembly ATPase SufC
APP_08310	ENOG4105JRK	feS assembly protein SufD
APP_08320	ENOG4105C9B	Cysteine desulfurase
APP_08330	ENOG4108UNV	SUF system FeS assembly protein, NifU family
APP_08340	ENOG4105DIW	FeS assembly protein SUFB
APP_08360	ENOG4105I3N	Conserved Protein
APP_08370	ENOG4107R8B	5'-nucleotidase
APP_08380	ENOG4105KZD	Domain of unknown function (DUF1805)
APP_08390	ENOG4105FAA	peptidase M23
APP_08400	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
APP_08410	ENOG4106EGE	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
APP_08420	ENOG4105MMD	transcriptional regulator
APP_08460	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
APP_08470	ENOG4108W5N	phosphatidylglycerophosphatase a
APP_08490	ENOG4105C5I	Dehydrogenase
APP_08500	ENOG4105D6E	homoserine dehydrogenase
APP_08510	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
APP_08520	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
APP_08530	ENOG41083MR	nifu domain-containing protein
APP_08570	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
APP_08580	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
APP_08590	ENOG4105CAY	ferredoxin--nadp reductase
APP_08600	ENOG4105CEP	NADH dehydrogenase
APP_08640	ENOG41069ER	domain protein
APP_08650	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
APP_08660	ENOG4105DCF	alanine dehydrogenase
APP_08740	ENOG4105BZU	Histidine kinase
APP_08760	ENOG4105KJM	monovalent cation h antiporter subunit g
APP_08780	ENOG4105SC1	monovalent cation H antiporter subunit E
APP_08790	ENOG4108JPZ	Monovalent cation H antiporter subunit D
APP_08800	ENOG4108ZE9	Monovalent cation H antiporter subunit C
APP_08810	ENOG4105HC0	Na H antiporter
APP_08820	ENOG4105D65	subunit l
APP_08850	ENOG4105Y38	Kinase-associated protein B
APP_08870	ENOG4105C87	Aminotransferase class I and II
APP_08890	ENOG4108MUZ	hydrolase
APP_08900	ENOG4108ZB6	transcriptional regulator AsnC family
APP_08910	ENOG4105CHM	Aminotransferase
APP_08930	ENOG4105WG9	Conserved Protein
APP_08940	ENOG4107QYV	phosphohexose isomerase
APP_08960	ENOG4107PBV	potassium channel
APP_08970	ENOG4107PBV	potassium channel
APP_08990	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
APP_09030	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
APP_09040	ENOG4105E4F	Isochorismate synthase
APP_09050	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
APP_09060	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
APP_09070	ENOG4108IPT	Naphthoate synthase
APP_09080	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_09100	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
APP_09110	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
APP_09120	ENOG4108RMU	ferritin dps family protein
APP_09150	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
APP_09170	ENOG4105D2X	ABC transporter substrate-binding protein
APP_09230	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
APP_09240	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
APP_09260	ENOG4108Z0R	Transferase
APP_09270	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
APP_09300	ENOG4105N5T	Radical SAM Protein
APP_09330	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
APP_09350	ENOG4105C8T	Leucyl-tRNA synthetase
APP_09360	ENOG41085GJ	domain protein
APP_09380	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
APP_09410	ENOG4105CBX	hi0933 family
APP_09440	ENOG4105YW5	deoR family transcriptional regulator
APP_09490	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
APP_09500	ENOG4105C7N	Xanthine uracil vitamin C permease
APP_09510	ENOG4107QSE	Dipeptidase
APP_09520	ENOG41080TC	multidrug resistance protein
APP_09530	ENOG410839T	multidrug resistance protein
APP_09540	ENOG4105C6T	cysteine synthase
APP_09570	ENOG41067MG	lrgb family
APP_09590	ENOG4108V15	phosphotransferase enzyme family
APP_09610	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
APP_09650	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
APP_09670	ENOG4108NKM	UPF0354 protein
APP_09680	ENOG4108VDD	TRNA binding domain protein
APP_09700	ENOG4107QP3	malate synthase g
APP_09730	ENOG4105XVF	Competence transcription factor
APP_09780	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
APP_09800	ENOG4105EYH	Exonuclease
APP_09870	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
APP_09890	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
APP_09900	ENOG4108I5D	sulfate abc transporter
APP_09910	ENOG4105ECW	sulfate abc transporter
APP_09930	ENOG4105GVF	(ABC) transporter
APP_09940	ENOG4105FBW	Monooxygenase
APP_09950	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APP_09960	ENOG4105E2Y	ABC, transporter
APP_09990	ENOG4108RE7	deoxyribonuclease
APP_10000	ENOG4105ERH	Fumarylacetoacetate hydrolase
APP_10040	ENOG4106NWU	
APP_10050	ENOG4108RDQ	ABC transporter
APP_10080	ENOG4105CAQ	asparagine synthetase
APP_10120	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
APP_10130	ENOG41088CQ	domain protein
APP_10210	ENOG4105BZ1	(ABC) transporter
APP_10230	ENOG4108IUW	ABC transporter
APP_10290	ENOG4108VPT	UPF0234 protein
APP_10320	ENOG4105EPR	degv family
APP_10340	ENOG4108KP7	hydrolase
APP_10350	ENOG4108MXZ	Esterase
APP_10360	ENOG4105VG1	fes assembly suf system protein
APP_10370	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
APP_10380	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
APP_10410	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
APP_10430	ENOG4105DBV	ornithine carbamoyltransferase
APP_10450	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
APP_10490	ENOG4107RMD	Basic membrane lipoprotein
APP_10510	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
APP_10520	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
APP_10560	ENOG4105C31	Tryptophanyl-tRNA synthetase
APP_10580	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
APP_10590	ENOG4108ZCF	integral membrane protein
APP_10600	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
APP_10610	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
APP_10630	ENOG4105DPN	Oligoendopeptidase f
APP_10640	ENOG4105T58	Dithiol-disulfide isomerase
APP_10650	ENOG4108Z18	K06886 hemoglobin
APP_10660	ENOG4105E4C	Lytic transglycosylase catalytic
APP_10670	ENOG4105MIX	Adenylate cyclase
APP_10710	ENOG4105EMS	pseudouridine synthase
APP_10720	ENOG4105CJW	magnesium transporter
APP_10740	ENOG4108VEU	Thiamine monophosphate synthase
APP_10770	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
APP_10780	ENOG4105D06	uba thif-type nad fad binding protein
APP_10790	ENOG4105DWF	phosphomethylpyrimidine kinase
APP_10800	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
APP_10900	ENOG4105H67	Protein of unknown function (DUF421)
APP_10920	ENOG4108ZMI	UPF0477 protein
APP_10960	ENOG4108J8Z	aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein
APP_10980	ENOG4105C28	cystathionine
APP_10990	ENOG4105C28	cystathionine
APP_11000	ENOG4105H1G	trap transporter solute receptor taxi family
APP_11110	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APP_11120	ENOG4107XVH	Transcriptional regulator
APP_11130	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
APP_11190	ENOG4105E39	Enoyl-CoA hydratase
APP_11200	ENOG4105CSH	Transporter
APP_11290	ENOG4105E5H	Transposase
APP_11360	ENOG4105C5Y	PTS System
APP_11370	ENOG4105CG3	alpha amylase, catalytic region
APP_11380	ENOG4107414	GntR family transcriptional regulator
APP_11430	ENOG4105E5H	Transposase
APP_11460	ENOG4105C5Y	PTS System
APP_11480	ENOG4105D7K	pfkb domain protein
APP_11510	ENOG4105KPY	Small multidrug resistance protein
APP_11520	ENOG4105E2B	Taurine dioxygenase
APP_11540	ENOG4106FTQ	Taurine ABC transporter, periplasmic
APP_11550	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
APP_11570	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
APP_11580	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
APP_11610	ENOG4108PJD	permease
APP_11630	ENOG4105RHY	Pfam:UPF0157
APP_11640	ENOG4105DHP	deoxycytidine triphosphate deaminase
APP_11650	ENOG4105CKI	cobalamin synthesis protein
APP_11660	ENOG4107T5J	pyridine nucleotide-disulfide oxidoreductase
APP_11690	ENOG4107R7Y	intracellular protease Pfpi family
APP_11710	ENOG4105CQB	FAD linked oxidase domain protein
APP_11720	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APP_11730	ENOG4105XXY	Thioredoxin
APP_11810	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
APP_11840	ENOG4105C26	Dehydrogenase
APP_11890	ENOG4105ECR	NmrA family
APP_11970	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_12000	ENOG4105CVR	type I restriction-modification system
APP_12040	ENOG4108JJ9	ABC, transporter
APP_12050	ENOG4108JJ8	(ABC) transporter
APP_12060	ENOG4108JJ8	(ABC) transporter
APP_12100	ENOG4105CJ1	ABC, transporter
APP_12130	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
APP_12140	ENOG4108IEG	Formate dehydrogenase Alpha subunit
APP_12160	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
APP_12200	ENOG4105C6Z	Gluconate
APP_12220	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
APP_12230	ENOG4105DRR	Transcriptional regulator, GntR family
APP_12240	ENOG4105CZM	Major Facilitator
APP_12250	ENOG4105MSY	salicylate hydroxylase
APP_12260	ENOG4105J4Q	Transcriptional regulator
APP_12290	ENOG41082UD	thioesterase Superfamily protein
APP_12300	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
APP_12320	ENOG4105CAK	Cell division ATP-binding protein ftsE
APP_12430	ENOG4106YBV	Methyl-accepting chemotaxis
APP_12470	ENOG4107258	Transcriptional regulator
APP_12480	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
APP_12500	ENOG4105CBC	glutamate synthase
APP_12530	ENOG4105BZU	Histidine kinase
APP_12540	ENOG4105C1G	acyl-Coa dehydrogenase
APP_12570	ENOG4105E3J	oxidoreductase
APP_12640	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
APP_12650	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
APP_12660	ENOG4105CHU	acetyl-coa acetyltransferase
APP_12670	ENOG4105C26	Dehydrogenase
APP_12680	ENOG4105E39	Enoyl-CoA hydratase
APP_12700	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
APP_12720	ENOG4105VG1	fes assembly suf system protein
APP_12750	ENOG4105E39	Enoyl-CoA hydratase
APP_12760	ENOG4105E39	Enoyl-CoA hydratase
APP_12790	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_12820	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
APP_12830	ENOG4105DVE	abc transporter atp-binding protein
APP_12850	ENOG4105EMN	RNA polymerase sigma factor
APP_12870	ENOG4105F0I	Aminotransferase
APP_12900	ENOG4105EKQ	RNA-directed DNA polymerase
APP_12910	ENOG4108SJC	Membrane
APP_12920	ENOG4107YZX	Universal stress protein
APP_12930	ENOG4108ZJ4	polysaccharide deacetylase
APP_12940	ENOG4105C3M	thioredoxin reductase
APP_12950	ENOG4105F0V	Cell wall hydrolase
APP_12990	ENOG4105F6S	Spore photoproduct lyase
APP_13000	ENOG4105C3M	thioredoxin reductase
APP_13040	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
APP_13050	ENOG4105EHG	Permease protein
APP_13060	ENOG4105E0A	ABC, transporter
APP_13070	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
APP_13080	ENOG4107QZB	decarboxylase
APP_13090	ENOG4108YZT	Adenosylcobinamide kinase
APP_13100	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
APP_13110	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
APP_13170	ENOG4105C37	(CBS) domain
APP_13180	ENOG4105EKQ	RNA-directed DNA polymerase
APP_13190	ENOG4105FKZ	Methyl-accepting chemotaxis
APP_13230	ENOG4105EVH	UPF0753 protein
APP_13240	ENOG4108TWJ	NADH dehydrogenase subunit 5
APP_13250	ENOG4105GPN	Uncharacterized conserved protein (DUF2294)
APP_13260	ENOG4105CFH	Aspartokinase
APP_13270	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_13280	ENOG4105EKQ	RNA-directed DNA polymerase
APP_13300	ENOG4105BZU	Histidine kinase
APP_13310	ENOG4105DQE	DNA ligase
APP_13320	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
APP_13330	ENOG4105FDF	Could be involved in DNA repair (By similarity)
APP_13340	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
APP_13350	ENOG410681C	small acid-soluble spore protein
APP_13360	ENOG4108IJ7	Glycine betaine
APP_13440	ENOG4107RVG	penicillin-binding protein
APP_13470	ENOG4107G43	radical SAM domain protein
APP_13480	ENOG4105JXH	GntR family transcriptional regulator
APP_13510	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APP_13520	ENOG4107QR9	Iron-sulfur cluster binding protein
APP_13530	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
APP_13540	ENOG4108TGC	Acyltransferase
APP_13550	ENOG4105BZU	Histidine kinase
APP_13560	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
APP_13570	ENOG4105CDW	Resistance protein
APP_13590	ENOG4105K8R	UPF0145 protein
APP_13640	ENOG4105BZU	Histidine kinase
APP_13650	ENOG41090MY	MarR family Transcriptional regulator
APP_13660	ENOG4105ER2	Ompa motb domain protein
APP_13670	ENOG4105E14	MotA TolQ exbB proton channel
APP_13690	ENOG4108K88	Membrane
APP_13700	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
APP_13710	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
APP_13720	ENOG4107ZAE	6-carboxy-5,6,7,8-tetrahydropterin synthase
APP_13730	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
APP_13750	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
APP_13800	ENOG4108B31	Spore germination protein
APP_13850	ENOG4105C59	p-type ATPase
APP_13870	ENOG4107Y9E	nuclease
APP_13880	ENOG4105CTQ	phosphohexokinase
APP_13930	ENOG4105CID	antiterminator
APP_13950	ENOG4105KRI	phosphocarrier protein (HPr
APP_13960	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
APP_13970	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
APP_13980	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
APP_13990	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
APP_14000	ENOG4105K4I	Scp-like extracellular
APP_14020	ENOG4105BZU	Histidine kinase
APP_14030	ENOG4105CHM	Aminotransferase
APP_14040	ENOG4105D7N	magnesium and cobalt transport protein CorA
APP_14070	ENOG4107R88	Chemotaxis protein (CheV)
APP_14080	ENOG4105UIN	
APP_14090	ENOG4105KTU	Transcriptional regulator, arsr family
APP_14130	ENOG4105EPM	Diguanylate phosphodiesterase
APP_14150	ENOG4105E0A	ABC, transporter
APP_14160	ENOG4108V5C	ABC transporter
APP_14170	ENOG4105DQ5	transport system permease protein
APP_14180	ENOG4105EHG	Permease protein
APP_14210	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APP_14240	ENOG4105CH2	amidohydrolase
APP_14250	ENOG4105D8X	mechanosensitive ion channel
APP_14260	ENOG4105D3R	alkyl hydroperoxide reductase
APP_14270	ENOG4107R19	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP_14300	ENOG4105ETU	transcriptional activator (TenA
APP_14310	ENOG4105ETU	transcriptional activator (TenA
APP_14320	ENOG4105ETU	transcriptional activator (TenA
APP_14340	ENOG4108JJB	ABC transporter
APP_14360	ENOG4107TSX	ABC branched chain amino acid family transporter periplasmic ligand binding protein
APP_14370	ENOG4105C32	Amino acid ABC transporter (Permease)
APP_14390	ENOG4105C0Z	ABC transporter
APP_14400	ENOG4108IV0	ABC, transporter
APP_14410	ENOG4108YZ9	Urea amidohydrolase subunit gamma
APP_14420	ENOG4105KI2	Urea amidohydrolase subunit beta
APP_14440	ENOG4105HFU	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
APP_14500	ENOG4105C1G	acyl-Coa dehydrogenase
APP_14510	ENOG4105CHR	reductase
APP_14520	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_14530	ENOG4105BZJ	Electron transfer flavoprotein
APP_14540	ENOG4105C10	Electron transfer flavoprotein
APP_14550	ENOG4105C1G	acyl-Coa dehydrogenase
APP_14560	ENOG4105CHU	acetyl-coa acetyltransferase
APP_14570	ENOG4105C1G	acyl-Coa dehydrogenase
APP_14580	ENOG4105CHR	reductase
APP_14590	ENOG410900P	UPF0336 protein
APP_14610	ENOG4105CHU	acetyl-coa acetyltransferase
APP_14620	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_14630	ENOG4105C32	Amino acid ABC transporter (Permease)
APP_14640	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
APP_14650	ENOG4105C0Z	ABC transporter
APP_14660	ENOG4108IV0	ABC, transporter
APP_14690	ENOG4105DKW	ABC transporter
APP_14700	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
APP_14760	ENOG4105DZC	cytosine deaminase
APP_14770	ENOG4105CS1	NAD(P)H quinone oxidoreductase
APP_14780	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
APP_14800	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
APP_14810	ENOG4107YV9	domain protein
APP_14820	ENOG4105DQ6	Transposase
APP_14880	ENOG4105G9B	Transcriptional regulator
APP_14900	ENOG4105C5R	Aminotransferase
APP_14910	ENOG4105CD3	dihydroorotase
APP_14920	ENOG4105DCM	major facilitator superfamily
APP_14930	ENOG4105EE0	oxidoreductase
APP_14940	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
APP_14950	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
APP_15010	ENOG4105YA8	Transcriptional regulator
APP_15040	ENOG4105DQ6	Transposase
APP_15080	ENOG4105E98	transcriptional regulator DeoR family
APP_15090	ENOG4105DE4	1-phosphofructokinase
APP_15100	ENOG4105DM4	PTS System
APP_15130	ENOG4105DQ6	Transposase
APP_15190	ENOG410874W	AraC family transcriptional regulator
APP_15230	ENOG4105NIV	Esterase
APP_15240	ENOG4107RRN	ABC transporter substrate-binding protein
APP_15250	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APP_15260	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APP_15280	ENOG4108JQ7	(ABC) transporter
APP_15290	ENOG4107R73	Mate efflux family protein
APP_15300	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
APP_15310	ENOG4105KZX	Pterin carbinolamine dehydratase
APP_15320	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
APP_15330	ENOG4105CPN	adenine deaminase
APP_15340	ENOG4105FGV	Chromate
APP_15350	ENOG4105CAH	Chromate
APP_15380	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
APP_15420	ENOG4105VRS	hydrolase family 18
APP_15430	ENOG4105C7Z	Conserved Protein
APP_15440	ENOG4105C7Z	Conserved Protein
APP_15480	ENOG4105DTN	riboflavin biosynthesis protein ribF
APP_15530	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
APP_15550	ENOG4107V6Q	Cyclic nucleotide-binding domain
APP_15580	ENOG4107X8C	Efflux transporter RND family MFP subunit
APP_15590	ENOG4105C19	ABC transporter
APP_15600	ENOG4107RBB	ABC transporter, permease
APP_15650	ENOG4105FDT	acyl-CoA dehydrogenase
APP_15660	ENOG4105EU0	Major facilitator Superfamily
APP_15700	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
APP_15720	ENOG4107ZYR	domain protein
APP_15730	ENOG4105CN5	Metallo-Beta-Lactamase
APP_15740	ENOG4106148	UPF0356 protein
APP_15750	ENOG4108X4Q	Hydrolase
APP_15760	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
APP_15790	ENOG4105CPP	Dehydrogenase, E1 component
APP_15800	ENOG4105C7S	Dehydrogenase
APP_15850	ENOG4105CXN	decarboxylase
APP_15860	ENOG4105EA8	2-Nitropropane dioxygenase
APP_15880	ENOG4105ECY	inositol monophosphatase
APP_15900	ENOG4105CI3	gtp-binding protein typa
APP_15910	ENOG4105QA2	
APP_15930	ENOG4108IAB	Phoh family
APP_15960	ENOG4105CNI	cell division protein FtsW
APP_15970	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
APP_15980	ENOG410890F	Dynamin family
APP_16010	ENOG41081VK	Ribonuclease
APP_16050	ENOG4105CVG	Homoserine O-transsuccinylase
APP_16060	ENOG4108V06	Glutathione peroxidase
APP_16080	ENOG4108Y6J	UPF0403 protein
APP_16110	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
APP_16120	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
APP_16130	ENOG4105C7B	Threonine dehydratase
APP_16150	ENOG4108RCR	degv family
APP_16160	ENOG4108KF3	Electron transport protein SCO1 SenC
APP_16170	ENOG41090WU	lipolytic protein G-D-S-L family
APP_16180	ENOG4105QZP	Uncharacterized protein conserved in bacteria (DUF2140)
APP_16190	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APP_16220	ENOG4105E0X	reductase
APP_16250	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
APP_16260	ENOG4105VSD	UPF0346 protein
APP_16280	ENOG4105G0J	serine threonine protein kinase
APP_16290	ENOG4108N23	SpoOM-related protein
APP_16300	ENOG410841Q	phosphoesterase PA-phosphatase related protein
APP_16310	ENOG4106Z5R	
APP_16330	ENOG4108VXD	carboxy-peptidase
APP_16370	ENOG4105FR1	rard protein
APP_16410	ENOG4105K4H	Nlp p60 protein
APP_16430	ENOG4108IQI	permease
APP_16440	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
APP_16450	ENOG4107T89	von Willebrand factor, type A
APP_16460	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
APP_16470	ENOG4105C7S	Dehydrogenase
APP_16490	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
APP_16500	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
APP_16530	ENOG4105C26	Dehydrogenase
APP_16560	ENOG4105WEF	catalase
APP_16590	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
APP_16650	ENOG4108YTE	sporulation protein YunB
APP_16680	ENOG41090VF	Stage v sporulation protein ac
APP_16690	ENOG4105CZ3	stage V sporulation protein ad
APP_16720	ENOG4108QY0	Membrane
APP_16730	ENOG4105C3M	thioredoxin reductase
APP_16750	ENOG4105C01	Dihydroxy-acid dehydratase
APP_16780	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
APP_16800	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
APP_16840	ENOG41079KZ	Major Facilitator Superfamily
APP_16850	ENOG41067SE	Tetr family transcriptional regulator
APP_16870	ENOG4108NNI	Beta-lactamase domain-containing protein
APP_16900	ENOG4106YBV	Methyl-accepting chemotaxis
APP_16940	ENOG4105VPX	protein, conserved in bacteria
APP_16960	ENOG41082MP	copper ion binding protein
APP_16980	ENOG4105KWG	Pfam:DUF1696
APP_17000	ENOG4105BZU	Histidine kinase
APP_17040	ENOG4105DY9	regulatoR
APP_17050	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
APP_17090	ENOG4105CW7	secretion protein, HlyD family
APP_17100	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APP_17130	ENOG4108RPX	mosc domain containing protein
APP_17160	ENOG4105CR4	methylisocitrate lyase
APP_17170	ENOG4105DXD	2-methylcitrate dehydratase
APP_17200	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
APP_17210	ENOG4105CPC	Aldo Keto reductase
APP_17250	ENOG4108HRK	Histidine kinase
APP_17260	ENOG4108NEV	two component transcriptional regulator, LytTR family
APP_17280	ENOG4105PF9	Transcriptional regulator
APP_17300	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
APP_17330	ENOG4105IIP	Membrane
APP_17340	ENOG4105W1N	transcriptional regulator
APP_17360	ENOG4107ZXU	DSBA oxidoreductase
APP_17380	ENOG4105EMN	RNA polymerase sigma factor
APP_17400	ENOG4105GVJ	transcriptional regulator
APP_17410	ENOG4105EYF	MMPL domain protein
APP_17420	ENOG4105VRS	hydrolase family 18
APP_17440	ENOG4105VEQ	Cold shock protein
APP_17450	ENOG4105C9U	ATP-dependent DNA helicase RecQ
APP_17470	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
APP_17550	ENOG410667J	hydrolase
APP_17560	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
APP_17570	ENOG4105ECK	Fatty Acid Desaturase
APP_17580	ENOG4108ZGX	Histidine kinase
APP_17590	ENOG4108S01	response regulator
APP_17610	ENOG4107TPS	domain protein
APP_17630	ENOG4105XTG	Pfam:DUF156
APP_17640	ENOG4105VFE	sira family
APP_17650	ENOG4105HF9	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
APP_17670	ENOG4105VFE	sira family
APP_17680	ENOG41087NI	Sulfite exporter TauE/SafE
APP_17690	ENOG4105WAB	arsR family transcriptional regulator
APP_17710	ENOG4105C0A	alcohol dehydrogenase
APP_17740	ENOG4105IW1	AmiS UreI transporter
APP_17750	ENOG4106H31	ATP-dependent protease ATP-binding subunit-like protein
APP_17810	ENOG4108W8G	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity)
APP_17820	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
APP_17830	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
APP_17840	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APP_17860	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
APP_17900	ENOG4108RDQ	ABC transporter
APP_17930	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_17940	ENOG41082BM	Transcriptional regulator, arsr family
APP_17970	ENOG4105CIG	ABC transporter
APP_17990	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
APP_18000	ENOG4105C09	Bile acid
APP_18040	ENOG4105C5H	ABC transporter
APP_18050	ENOG4105DHI	Methyltransferase
APP_18060	ENOG4105DHI	Methyltransferase
APP_18080	ENOG4105U5Y	Transcriptional regulator
APP_18090	ENOG4105C1G	acyl-Coa dehydrogenase
APP_18100	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_18110	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APP_18120	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
APP_18130	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
APP_18140	ENOG4105E39	Enoyl-CoA hydratase
APP_18150	ENOG4107QX3	carboxylase
APP_18210	ENOG4105EMD	TRANSCRIPTIONal
APP_18220	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
APP_18230	ENOG4105CTQ	phosphohexokinase
APP_18250	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
APP_18280	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
APP_18290	ENOG4105E0C	molybdate abc transporter
APP_18300	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
APP_18310	ENOG4108R96	Methyltransferase, YaeB family
APP_18320	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
APP_18330	ENOG4105E1F	short-chain dehydrogenase reductase
APP_18340	ENOG4108HFV	
APP_18360	ENOG4105C1G	acyl-Coa dehydrogenase
APP_18370	ENOG4105D01	(LipO)protein
APP_18380	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
APP_18390	ENOG4108UMI	ABC transporter, permease
APP_18400	ENOG41082YX	Transcriptional regulator, arsr family
APP_18420	ENOG4105D6J	arsenicaL-resistance protein
APP_18430	ENOG4105D6J	arsenicaL-resistance protein
APP_18440	ENOG4108UXE	Protein tyrosine phosphatase
APP_18460	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
APP_18470	ENOG4107EPV	Aminotransferase class V
APP_18480	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
APP_18490	ENOG4105C1G	acyl-Coa dehydrogenase
APP_18550	ENOG4105C4B	ABC transporter, permease
APP_18560	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APP_18590	ENOG4108ZAF	Molybdopterin
APP_18600	ENOG4108129	molybdopterin-guanine dinucleotide biosynthesis protein
APP_18610	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
APP_18620	ENOG41082CS	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
APP_18630	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
APP_18650	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APP_18700	ENOG4105VG1	fes assembly suf system protein
APP_18720	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
APP_18730	ENOG4107V6Q	Cyclic nucleotide-binding domain
APP_18760	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
APP_18780	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APP_18790	ENOG4105K4P	CoA-binding domain protein
APP_18800	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
APP_18810	ENOG4105DVT	helicase
APP_18850	ENOG4105W8X	HesB YadR YfhF-family protein
APP_18860	ENOG4105MI2	
APP_18910	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP_18920	ENOG4108I0Z	Aconitate hydratase
APP_18980	ENOG4107YTP	response regulator receiver protein
APP_18990	ENOG4107QIV	Cytochrome c biogenesis protein
APP_19010	ENOG4105VXM	UPF0154 protein
APP_19040	ENOG4105VPS	UPF0291 protein
APP_19050	ENOG4108SVB	resolvase
APP_19070	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
APP_19080	ENOG4105D82	Glutamate dehydrogenase
APP_19090	ENOG4105F6E	Acyl-transferase
APP_19100	ENOG4108URH	decarboxylase
APP_19110	ENOG4107SET	aldo keto reductase
APP_19120	ENOG4105FBA	Phospholipase Carboxylesterase
APP_19130	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
APP_19200	ENOG4105ENE	Histidine kinase
APP_19210	ENOG4105WH1	Two component transcriptional regulator luxr family
APP_19230	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_19240	ENOG4105BZU	Histidine kinase
APP_19300	ENOG4108KK1	membrane protein AbrB duplication
APP_19310	ENOG4108KAM	Transcriptional regulator
APP_19370	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APP_19380	ENOG4105BZU	Histidine kinase
APP_19400	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
APP_19430	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
APP_19440	ENOG4105E39	Enoyl-CoA hydratase
APP_19480	ENOG4105EHG	Permease protein
APP_19490	ENOG4105DQ5	transport system permease protein
APP_19540	ENOG4105E5H	Transposase
APP_19580	ENOG4105BZ1	(ABC) transporter
APP_19600	ENOG4105E5H	Transposase
APP_19670	ENOG4105E5H	Transposase
APP_19710	ENOG4105CMG	Carbohydrate kinase
APP_19740	ENOG4105DQ6	Transposase
APP_19750	ENOG4105DQ6	Transposase
APP_19770	ENOG41073TP	transcriptional regulator
APP_19780	ENOG4105UVJ	5-dehydro-4-deoxyglucarate dehydratase
APP_19790	ENOG4105CTX	dehydratase
APP_19800	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
APP_19810	ENOG4105DJB	Major Facilitator Superfamily
APP_19840	ENOG4105ETD	TRANSCRIPTIONal
APP_19870	ENOG4105C0A	alcohol dehydrogenase
APP_19890	ENOG4107SET	aldo keto reductase
APP_19910	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APP_19930	ENOG4107QSA	Oxaloacetate decarboxylase
APP_19940	ENOG4105DZS	Phenylacetate-CoA ligase
APP_19950	ENOG4107258	Transcriptional regulator
APP_19960	ENOG4107HP6	Transcriptional regulator
APP_20020	ENOG4105E5H	Transposase
APP_20070	ENOG4105CHR	reductase
APP_20200	ENOG4105C5F	glutamine synthetase
APP_20210	ENOG4105KV4	Transcriptional regulator
APP_20220	ENOG4105CXI	aluminum resistance protein
APP_20230	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
APP_20250	ENOG4106F1P	AAA ATPase, central domain protein
APP_20260	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
APP_20270	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
APP_20290	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
APP_20300	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
APP_20310	ENOG4105EKQ	RNA-directed DNA polymerase
APP_20340	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APP_20350	ENOG4105DQU	oxidoreductase, subunit beta
APP_20360	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
APP_20370	ENOG4105MCT	stage V sporulation protein S
APP_20380	ENOG4105D48	metallophosphoesterase
APP_20390	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
APP_20400	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
APP_20410	ENOG4105CEV	competence damage-inducible protein
APP_20420	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
APP_20450	ENOG4105XZV	Protein of unknown function (DUF3243)
APP_20460	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
APP_20520	ENOG4105CNU	cell division protein FtsK
APP_20540	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
APP_20560	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
APP_20580	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
APP_20590	ENOG4108S0H	Dipicolinic acid synthetase, b subunit
APP_20600	ENOG4105E35	Dipicolinate synthase subunit A
APP_20620	ENOG4105C1V	Peptidase, M16
APP_20640	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APP_20650	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
APP_20660	ENOG4105DTN	riboflavin biosynthesis protein ribF
APP_20670	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
APP_20680	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
APP_20690	ENOG4105W7A	Protein of unknown function (DUF503)
APP_20700	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
APP_20710	ENOG4105VHM	ribosomal protein
APP_20720	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
APP_20730	ENOG4105CHV	Transcription elongation factor NusA
APP_20740	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
APP_20750	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
APP_20760	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
APP_20770	ENOG4105DZP	Membrane-associated zinc metalloprotease
APP_20790	ENOG4105KNE	Phosphatidate cytidylyltransferase
APP_20800	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
APP_20810	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
APP_20820	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
APP_20830	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
APP_20840	ENOG4105CE9	30S ribosomal protein S2
APP_20860	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_20870	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
APP_20890	ENOG410807Z	Modulation of CheA activity in response to attractants (Chemotaxis
APP_20900	ENOG4105CBS	Chea signal transduction histidine kinase
APP_20910	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
APP_20930	ENOG4105FZW	flagellar biosynthesis regulator FlhF
APP_20940	ENOG4105D7B	Flagellar biosynthesis protein flha
APP_20950	ENOG4105D00	flagellar biosynthetic protein flhB
APP_20960	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
APP_20970	ENOG4105VS8	Flagellar biosynthetic protein fliq
APP_20980	ENOG4105CN7	Flagellar biosynthetic protein FliP
APP_21000	ENOG4107YTP	response regulator receiver protein
APP_21010	ENOG4105DD5	Flagellar motor switch protein
APP_21020	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
APP_21040	ENOG41068WV	flagellar FlbD family protein
APP_21050	ENOG4108JQA	flagellar
APP_21060	ENOG410822I	Flagellar hook capping protein
APP_21070	ENOG410696Y	Flagellar hook-length control protein
APP_21090	ENOG4106YF4	Flagellar biosynthesis chaperone
APP_21120	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
APP_21130	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
APP_21140	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
APP_21150	ENOG4108ZC9	flagellar basal-body rod protein flgc
APP_21160	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
APP_21170	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
APP_21180	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
APP_21190	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
APP_21200	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APP_21210	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
APP_21220	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
APP_21230	ENOG4105C79	DNA protecting protein DprA
APP_21240	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
APP_21250	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
APP_21260	ENOG4105VM1	flagellar
APP_21280	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APP_21310	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
APP_21330	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
APP_21360	ENOG4105VB6	UPF0109 protein
APP_21370	ENOG4105K5M	30s ribosomal protein S16
APP_21390	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
APP_21400	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APP_21410	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
APP_21420	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
APP_21430	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
APP_21440	ENOG4105CHR	reductase
APP_21450	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
APP_21460	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
APP_21470	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
APP_21480	ENOG4105CB5	ATP-dependent DNA helicase recG
APP_21490	ENOG4105DP4	dak2 domain fusion protein ylov
APP_21500	ENOG4108ZAA	Alkaline-shock protein
APP_21510	ENOG4105VB9	50S ribosomal protein l28
APP_21520	ENOG4105DJV	ribulose-phosphate 3-epimerase
APP_21530	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
APP_21540	ENOG4105D9P	serine threonine protein kinase
APP_21550	ENOG4108ZF3	Phosphatase
APP_21560	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APP_21570	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APP_21590	ENOG4105C25	Primosomal protein n'
APP_21600	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
APP_21620	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
APP_21630	ENOG4105KC4	UPF0296 protein
APP_21640	ENOG4105DSJ	YicC domain protein
APP_21670	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
APP_21680	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
APP_21700	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
APP_21710	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
APP_21720	ENOG4107RIQ	Sulfate adenylate transferase
APP_21730	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
APP_21740	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
APP_21750	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
APP_21760	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
APP_21770	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
APP_21780	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
APP_21810	ENOG4105CXT	aspartate transcarbamylase
APP_21830	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
APP_21840	ENOG4105C34	Pseudouridine synthase
APP_21850	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
APP_21870	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
APP_21900	ENOG4105DBK	s4 domain protein
APP_21910	ENOG41067XK	integral membrane protein
APP_21920	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
APP_21930	ENOG4105DFA	alanine racemase domain protein
APP_21940	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
APP_21950	ENOG4105WR5	sporulation protein, YlmC YmxH family
APP_21980	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_21990	ENOG4108AWX	Sporulation factor SpoIIGA 
APP_22000	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
APP_22010	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
APP_22020	ENOG4105K67	small basic protein
APP_22040	ENOG4108R2U	division initiation protein
APP_22050	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
APP_22060	ENOG4105D4A	Cell wall formation (By similarity)
APP_22070	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
APP_22080	ENOG4105CNI	cell division protein FtsW
APP_22090	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
APP_22100	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
APP_22110	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
APP_22120	ENOG4105CJN	penicillin-binding protein
APP_22130	ENOG4105CJN	penicillin-binding protein
APP_22150	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
APP_22160	ENOG4108V6E	Cell division protein mraZ
APP_22170	ENOG41074B2	UPF0747 protein
APP_22220	ENOG41067VY	50S ribosomal protein L32
APP_22230	ENOG4105KNH	Nucleic acid-binding protein
APP_22240	ENOG4105CDE	UPF0348 protein
APP_22250	ENOG41063PX	domain protein
APP_22260	ENOG4105D78	K07001 NTE family protein
APP_22270	ENOG4105H20	Sporulation integral membrane protein YlbJ
APP_22280	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
APP_22290	ENOG4106H78	methyltransferase
APP_22310	ENOG4105WUC	UPF0298 protein
APP_22360	ENOG4106UY4	Inherit from COG: Scp-like extracellular
APP_22370	ENOG41080XQ	Signal transduction protein with cbs domains
APP_22400	ENOG41064X9	cytochrome C oxidase subunit IV
APP_22410	ENOG4105CCU	oxidase (Subunit III)
APP_22420	ENOG4105BZ9	Cytochrome C oxidase, subunit I
APP_22440	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
APP_22450	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
APP_22460	ENOG4105CTD	carboxy-peptidase
APP_22470	ENOG4105DVT	helicase
APP_22490	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
APP_22520	ENOG4107X2U	Inherit from COG: Exonuclease-like protein
APP_22530	ENOG4108I5C	dEAD DEAH box helicase
APP_22610	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
APP_22620	ENOG4105BZ4	penicillin-binding protein
APP_22640	ENOG4105CSM	endonuclease III
APP_22660	ENOG4105C5S	asparaginyl-tRNA synthetase
APP_22670	ENOG4105CHM	Aminotransferase
APP_22690	ENOG4105YAC	
APP_22710	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
APP_22720	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
APP_22730	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
APP_22750	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APP_22760	ENOG4105CPK	Glycosyl transferase (Group 1
APP_22770	ENOG4108Z5K	methylglyoxal synthase
APP_22780	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
APP_22790	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
APP_22800	ENOG4108JYZ	YitT family
APP_22840	ENOG4105BZG	amino acid carrier protein
APP_22860	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APP_22870	ENOG4105DQV	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
APP_22890	ENOG4108SXZ	UPF0302 protein
APP_22900	ENOG41068YB	TPR repeat-containing protein
APP_22920	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
APP_22940	ENOG4105CIH	Imidazole acetol-phosphate transaminase
APP_22950	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
APP_22970	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
APP_22980	ENOG4105DK0	Indole-3-glycerol phosphate synthase
APP_22990	ENOG4108I0Q	anthranilate phosphoribosyltransferase
APP_23010	ENOG4105KHN	chorismate mutase
APP_23020	ENOG4105D49	3-dehydroquinate synthase
APP_23030	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
APP_23040	ENOG4105BZU	Histidine kinase
APP_23050	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
APP_23060	ENOG4105EAH	synthase
APP_23070	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APP_23080	ENOG4105XXQ	heptaprenyl diphosphate synthase component I
APP_23090	ENOG4105WP2	Tryptophan RNA-binding attenuator protein
APP_23100	ENOG4105EUJ	GTP cyclohydrolase i
APP_23110	ENOG4105K70	DNA-binding protein
APP_23140	ENOG4106UIA	
APP_23180	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
APP_23210	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
APP_23220	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
APP_23230	ENOG41065D1	
APP_23240	ENOG4105S2F	
APP_23270	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
APP_23280	ENOG4105F6E	Acyl-transferase
APP_23290	ENOG4105CAT	Cytidine monophosphate kinase
APP_23320	ENOG4105MSI	germination protein ypeb
APP_23340	ENOG4108PNU	Involved in the degradation of specific anti-sigma factors (By similarity)
APP_23350	ENOG4105HDK	L-asparaginase
APP_23360	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
APP_23410	ENOG4105I7S	Abortive infection protein
APP_23420	ENOG4105C9U	ATP-dependent DNA helicase RecQ
APP_23430	ENOG4105T7X	
APP_23450	ENOG4108SAX	Membrane
APP_23470	ENOG4108JQ1	Dehydrogenase
APP_23510	ENOG4108WBT	adenosyltransferase
APP_23520	ENOG4105BZU	Histidine kinase
APP_23530	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APP_23540	ENOG4105CRE	cytochrome C
APP_23550	ENOG4107TWT	Cytochrome c biogenesis protein
APP_23560	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP_23570	ENOG4105FE9	pseudouridine synthase
APP_23590	ENOG4108JIC	nucleoside recognition domain protein
APP_23600	ENOG4105DZ1	carboxypeptidase
APP_23610	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
APP_23620	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
APP_23650	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
APP_23660	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
APP_23670	ENOG4108R6K	riboflavin synthase, subunit alpha
APP_23690	ENOG4107ZE5	PPIases accelerate the folding of proteins
APP_23700	ENOG4105PTM	secreted protein
APP_23710	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
APP_23730	ENOG4105CZ3	stage V sporulation protein ad
APP_23760	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_23770	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
APP_23780	ENOG41082AN	stage II sporulation protein
APP_23790	ENOG4105DZ1	carboxypeptidase
APP_23830	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APP_23850	ENOG4105I3K	Ferric uptake regulator, Fur family
APP_23860	ENOG4105MZ9	stage II sporulation protein m
APP_23880	ENOG4108YZ4	nudix hydrolase
APP_23900	ENOG4105CPC	Aldo Keto reductase
APP_23950	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
APP_23960	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APP_23970	ENOG4108ZMX	Domain of unknown function (DU1801)
APP_23980	ENOG4108ZMX	Domain of unknown function (DU1801)
APP_24030	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
APP_24050	ENOG4108IXY	short-chain dehydrogenase reductase
APP_24060	ENOG41069FQ	Metallo-beta-lactamase superfamily
APP_24070	ENOG4105II7	pyrroline-5-carboxylate reductase
APP_24080	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APP_24090	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
APP_24110	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
APP_24120	ENOG410855V	Acylphosphatase
APP_24130	ENOG4108HWW	ABC transporter
APP_24140	ENOG4105C2J	ABC transporter
APP_24150	ENOG4105DFW	ABC transporter
APP_24160	ENOG4108VAC	response regulator
APP_24170	ENOG4105C2F	Histidine kinase
APP_24190	ENOG4105EWU	Squalene--hopene cyclase
APP_24210	ENOG4105C2J	ABC transporter
APP_24220	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
APP_24230	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
APP_24240	ENOG4105BZ8	glutamate synthase
APP_24250	ENOG4105CBC	glutamate synthase
APP_24260	ENOG4105C5Q	Transcriptional regulator
APP_24270	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
APP_24280	ENOG4108QEG	Membrane
APP_24290	ENOG4108Y6J	UPF0403 protein
APP_24300	ENOG4105C7S	Dehydrogenase
APP_24310	ENOG4105CPP	Dehydrogenase, E1 component
APP_24340	ENOG4106CCJ	Protein of unknown function (DUF2627)
APP_24350	ENOG4107QQR	Sporulation
APP_24360	ENOG4105S1Z	Stage IV sporulation protein B
APP_24370	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
APP_24380	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
APP_24390	ENOG4105DX0	Hemolysin A
APP_24400	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
APP_24430	ENOG4105CTB	Polyprenyl synthetase
APP_24440	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
APP_24450	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
APP_24460	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
APP_24470	ENOG4105M7K	Involved in the transcription termination process (By similarity)
APP_24480	ENOG4108ZSR	alkaline shock protein
APP_24490	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APP_24530	ENOG410644B	Stage III sporulation protein af
APP_24550	ENOG4105KQ4	Stage iii sporulation protein ad
APP_24560	ENOG4108CQH	stage III sporulation protein AC
APP_24570	ENOG4105KR5	Stage iii sporulation protein
APP_24580	ENOG4105CD2	stage iii sporulation protein aa
APP_24600	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
APP_24610	ENOG4105DC7	peptidase M24
APP_24640	ENOG4105CBJ	Metal-dependent enzyme
APP_24670	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APP_24680	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
APP_24690	ENOG4105WZW	rhodanese family
APP_24700	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APP_24710	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APP_24720	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
APP_24730	ENOG4105C0D	helicase
APP_24800	ENOG4106855	Competence protein
APP_24840	ENOG4105C5X	domain protein
APP_24880	ENOG4105E0M	Sulfatase
APP_24910	ENOG4107ZXI	Rhomboid family
APP_24930	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
APP_24940	ENOG4105WDJ	50S ribosomal protein L33
APP_24960	ENOG41068DG	YceG-like family
APP_24970	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
APP_24980	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
APP_24990	ENOG4105E2Z	phosphate ABC transporter (Permease
APP_25000	ENOG4105C8U	phosphate abc transporter
APP_25010	ENOG4105EXS	phosphate abc transporter
APP_25050	ENOG4105SXS	Protein of unknown function (DUF456)
APP_25090	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_25120	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
APP_25130	ENOG41063Y9	
APP_25150	ENOG4105N80	Ferric uptake regulator, Fur family
APP_25160	ENOG4105FAV	ABC, transporter
APP_25170	ENOG4105FDK	ABC transporter
APP_25180	ENOG4108JYZ	YitT family
APP_25190	ENOG41069ZM	Protein of unknown function (DUF2624)
APP_25200	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
APP_25230	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
APP_25240	ENOG4105EGD	dinuclear metal center protein, YbgI family
APP_25270	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_25280	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
APP_25300	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
APP_25320	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
APP_25330	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
APP_25340	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
APP_25360	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
APP_25370	ENOG4105KG3	cytidine deaminase
APP_25380	ENOG4107YR5	Diacylglycerol kinase
APP_25390	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
APP_25400	ENOG4105CTJ	Metal Dependent Phosphohydrolase
APP_25410	ENOG4105C9A	Phoh family
APP_25430	ENOG41068P3	sporulation protein YqfC
APP_25450	ENOG4105DI5	UPF0365 protein
APP_25460	ENOG4105F7J	membrane-bound serine protease
APP_25470	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
APP_25500	ENOG4105KTH	gatB Yqey
APP_25510	ENOG4105VCC	30S ribosomal protein S21
APP_25530	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
APP_25540	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APP_25550	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
APP_25560	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
APP_25570	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
APP_25580	ENOG4105CFG	Acts as a chaperone (By similarity)
APP_25600	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
APP_25610	ENOG4105CSA	Coproporphyrinogen iii oxidase
APP_25620	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
APP_25640	ENOG4108ZRV	stage ii sporulation protein p
APP_25660	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
APP_25670	ENOG4105TQK	DNA polymerase iii, delta' subunit
APP_25690	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
APP_25700	ENOG4108UK2	deaminase
APP_25710	ENOG4105KQC	Competence protein
APP_25730	ENOG4108D32	Methyltransferase
APP_25750	ENOG4108WF2	Metal Dependent Phosphohydrolase
APP_25760	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
APP_25770	ENOG410812S	Rna-binding protein
APP_25780	ENOG4105E2X	shikimate dehydrogenase
APP_25790	ENOG4105CQW	ribosome biogenesis GTPase YqeH
APP_25800	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
APP_25820	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APP_25840	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
APP_25860	ENOG4107XRG	penicillin-binding protein
APP_25870	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
APP_25880	ENOG4105CFP	Peptidase U32
APP_25890	ENOG4105XYU	peptidase (U32 family)
APP_25910	ENOG4105HHA	aminodeoxychorismate lyase
APP_25920	ENOG4105VPH	UPF0473 protein
APP_25930	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
APP_25940	ENOG4105VBH	UPF0297 protein
APP_25950	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
APP_25960	ENOG4105C02	permease
APP_25970	ENOG41060CR	
APP_25980	ENOG4105C7H	Helicase, RecD TraA family
APP_26000	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
APP_26010	ENOG4105C3J	Cysteine desulfurase
APP_26030	ENOG4105D1H	recombination factor protein RarA
APP_26040	ENOG4105CUZ	uba thif-type nad fad binding protein
APP_26050	ENOG4105C9M	aspartyl-trna synthetase
APP_26060	ENOG4105CUT	histidyl-tRNA synthetase
APP_26080	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
APP_26090	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
APP_26100	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
APP_26110	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
APP_26120	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
APP_26160	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
APP_26180	ENOG4105CKP	Polysaccharide Biosynthesis Protein
APP_26190	ENOG4105NAP	
APP_26200	ENOG4105VIE	preprotein translocase, subunit YajC
APP_26210	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
APP_26220	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
APP_26230	ENOG41061AI	Protein of unknown function (DUF2905)
APP_26240	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
APP_26250	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
APP_26270	ENOG4105CDY	transcriptional regulatory protein
APP_26290	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
APP_26300	ENOG4106678	morphogenetic protein associated with SpoVID
APP_26310	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
APP_26320	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
APP_26330	ENOG4108IYU	L-aspartate oxidase
APP_26360	ENOG4105CQC	Prephenate dehydratase
APP_26370	ENOG41090I5	UPF0735 ACT domain-containing protein
APP_26380	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APP_26400	ENOG4105K46	50S ribosomal protein l27
APP_26410	ENOG4105X36	(ribosomal) protein
APP_26420	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
APP_26430	ENOG4105C03	ribonuclease
APP_26460	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
APP_26470	ENOG4107Y03	Nitroreductase
APP_26480	ENOG4107QMS	site-determining protein
APP_26490	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
APP_26500	ENOG4105YHC	Rod shape-determining protein MreD
APP_26520	ENOG4105DFF	Rod shape-determining protein mreb
APP_26530	ENOG4105W5Q	DNA repair protein (RadC
APP_26540	ENOG4108Z03	MAF-like protein
APP_26560	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
APP_26600	ENOG41068KH	stage VI sporulation protein D
APP_26610	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
APP_26620	ENOG4105D52	delta-aminolevulinic acid dehydratase
APP_26640	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
APP_26660	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
APP_26680	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
APP_26690	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
APP_26700	ENOG4108IUQ	atp-dependent protease
APP_26710	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
APP_26720	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
APP_26740	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APP_26750	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APP_26760	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
APP_26770	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
APP_26780	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
APP_26790	ENOG4108ZP8	Acetolactate synthase small subunit
APP_26800	ENOG4105C7K	acetolactate synthase
APP_26840	ENOG4105CTQ	phosphohexokinase
APP_26870	ENOG4105CHR	reductase
APP_26880	ENOG4108IUS	Transketolase
APP_26890	ENOG4105CV1	Transketolase (EC 2.2.1.1)
APP_26910	ENOG4107YCY	Transcriptional regulator
APP_26940	ENOG4108PNI	recT protein
APP_26950	ENOG4108PNI	recT protein
APP_26990	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APP_27000	ENOG4105M59	Phosphodiesterase, mj0936 family
APP_27010	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
APP_27020	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
APP_27030	ENOG4108XJQ	germination protein
APP_27040	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
APP_27050	ENOG41067TZ	transcriptional regulator, MarR family
APP_27060	ENOG4105PFC	Transcriptional regulator
APP_27070	ENOG4105E33	succinate dehydrogenase
APP_27090	ENOG4108NU2	Succinate dehydrogenase cytochrome b558 subunit
APP_27110	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
APP_27120	ENOG4105K63	Thioredoxin
APP_27130	ENOG4105C10	Electron transfer flavoprotein
APP_27140	ENOG4105BZJ	Electron transfer flavoprotein
APP_27150	ENOG4107Z3H	Transcriptional regulator, TetR family
APP_27160	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_27180	ENOG4105C98	muts2 protein
APP_27190	ENOG4105DCG	PHP domain protein
APP_27210	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
APP_27220	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APP_27230	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
APP_27240	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
APP_27260	ENOG4108RWN	rrna methyltransferase
APP_27280	ENOG4105CN9	Peptidase m42 family protein
APP_27310	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
APP_27320	ENOG4105VJV	50s ribosomal protein L35
APP_27330	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
APP_27340	ENOG4106GRI	small acid-soluble spore protein H
APP_27350	ENOG4105HNY	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
APP_27360	ENOG4105C22	threonyL-tRNA synthetase
APP_27370	ENOG4108TDW	sporulation protein YtxC
APP_27400	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
APP_27410	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
APP_27420	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
APP_27450	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
APP_27460	ENOG4105C2M	dna polymerase I
APP_27470	ENOG4105EPW	hflc protein
APP_27480	ENOG4107QJR	hflk protein
APP_27490	ENOG4105BZU	Histidine kinase
APP_27500	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
APP_27520	ENOG4108HMX	isocitrate dehydrogenase (NADP)
APP_27530	ENOG4105BZN	citrate synthase
APP_27540	ENOG4105FS0	cytoplasmic membrane protein
APP_27550	ENOG4105CA9	Pyruvate kinase
APP_27560	ENOG4105CTQ	phosphohexokinase
APP_27570	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
APP_27580	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
APP_27590	ENOG4105C6K	Malic enzyme
APP_27600	ENOG4105C0B	DNA polymerase III (alpha subunit)
APP_27610	ENOG4105VV2	
APP_27630	ENOG4105SFS	phosphoesterase RecJ domain protein
APP_27660	ENOG4105E8R	UPF0173 metal-dependent hydrolase
APP_27690	ENOG4105CH7	arginosuccinase
APP_27700	ENOG4105CDH	Citrulline--aspartate ligase
APP_27740	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
APP_27770	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
APP_27780	ENOG4105KBJ	sporulation protein ytfj
APP_27800	ENOG4105VK3	rdd domain containing protein
APP_27810	ENOG4105D07	Signal peptide peptidase, SppA
APP_27820	ENOG4108KKH	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
APP_27840	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
APP_27860	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APP_27870	ENOG4105CV8	reductase
APP_27900	ENOG4105U5Y	Transcriptional regulator
APP_27920	ENOG4105BZU	Histidine kinase
APP_27930	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
APP_28010	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
APP_28020	ENOG4105ERH	Fumarylacetoacetate hydrolase
APP_28030	ENOG4107GFK	fumarate
APP_28040	ENOG4106DSS	Tartrate dehydratase subunit alpha
APP_28050	ENOG4105C8P	)-transporter
APP_28120	ENOG4105D5G	Transposase
APP_28190	ENOG4105F1V	Acetoin utilization protein
APP_28200	ENOG4105W87	Cbs domain
APP_28210	ENOG4105DGU	Histone deacetylase
APP_28220	ENOG4105ETE	Transcriptional regulator (LacI family
APP_28230	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
APP_28260	ENOG4105C88	aminopeptidase
APP_28270	ENOG4105DFU	Cell wall formation (By similarity)
APP_28290	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
APP_28310	ENOG4108UMN	azlc family
APP_28320	ENOG4108JCI	Transcriptional regulator
APP_28340	ENOG4105C7J	ABC transporter, permease
APP_28360	ENOG4108RQ5	Beta-lactamase domain-containing protein
APP_28380	ENOG4105C1Q	protoporphyrinogen oxidase
APP_28390	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
APP_28400	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
APP_28410	ENOG4105BZ4	penicillin-binding protein
APP_28420	ENOG4105Q24	Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation
APP_28450	ENOG4105K59	histidine triad (HIT) protein
APP_28460	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
APP_28470	ENOG4105NBU	tryptophan transport protein
APP_28530	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
APP_28550	ENOG4105EQI	Metal Dependent Phosphohydrolase
APP_28560	ENOG4106D4I	domain protein
APP_28570	ENOG4107VRP	DNA repair exonuclease
APP_28600	ENOG4105D4P	Coproporphyrinogen iii oxidase
APP_28640	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
APP_28650	ENOG4105WZB	UPF0342 protein
APP_28690	ENOG4105E1K	spore germination protein
APP_28700	ENOG4108UH6	UPF0754 membrane protein
APP_28730	ENOG410839P	
APP_28740	ENOG410839P	
APP_28790	ENOG4105C5Q	Transcriptional regulator
APP_28850	ENOG4105C0Z	ABC transporter
APP_28860	ENOG4108IV0	ABC, transporter
APP_28870	ENOG4106YBV	Methyl-accepting chemotaxis
APP_28890	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APP_28900	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APP_28920	ENOG4105WMR	Protein CrcB homolog
APP_28940	ENOG4105C02	permease
APP_28950	ENOG4108REF	Sporulation integral membrane protein ytvi
APP_28970	ENOG4108ZCF	integral membrane protein
APP_28980	ENOG4105ED1	spovr family
APP_29000	ENOG4105KPV	Transcriptional regulator
APP_29030	ENOG41080XP	Cbs domain
APP_29070	ENOG4105DYS	nad(p)h dehydrogenase (quinone)
APP_29090	ENOG4107T5V	SNARE associated Golgi
APP_29100	ENOG4105CHU	acetyl-coa acetyltransferase
APP_29110	ENOG4107F3J	Amp-dependent synthetase and ligase
APP_29120	ENOG4107ZYJ	bioY protein
APP_29140	ENOG4106AKX	UPF0229 protein
APP_29150	ENOG4105CYN	Serine protein kinase
APP_29190	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
APP_29250	ENOG4105DXX	methyltransferase
APP_29260	ENOG4108UZX	fmn reductase
APP_29270	ENOG4105E98	transcriptional regulator DeoR family
APP_29280	ENOG4105IE8	Alpha-ketoglutarate permease
APP_29290	ENOG4105EJJ	Dehydrogenase
APP_29300	ENOG4108HMQ	sugar kinase
APP_29330	ENOG4105C26	Dehydrogenase
APP_29340	ENOG4105C0A	alcohol dehydrogenase
APP_29350	ENOG4105BZU	Histidine kinase
APP_29360	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
APP_29370	ENOG4107QKR	Dehydrogenase
APP_29390	ENOG4107RUY	(E1 component), alpha subunit
APP_29410	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
APP_29420	ENOG410650H	(LipO)protein
APP_29430	ENOG4105DBE	peroxidase
APP_29470	ENOG4105DEN	Luciferase family
APP_29480	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
APP_29490	ENOG4108Z40	Transcriptional regulator
APP_29500	ENOG4105N14	lysine exporter protein LysE YggA
APP_29550	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
APP_29570	ENOG4105KRI	phosphocarrier protein (HPr
APP_29600	ENOG4105CMT	Dihydroxyacetone kinase
APP_29610	ENOG4108JUB	Transcriptional regulator
APP_29620	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
APP_29630	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
APP_30060	ENOG4105QBX	endodeoxyribonuclease RusA
APP_30090	ENOG4105CDU	Replicative dna helicase
APP_30110	ENOG4108PNI	recT protein
APP_30120	ENOG4108NF7	phage-type endonuclease
APP_30190	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APP_30200	ENOG4105TUA	UPF0295 protein
APP_30210	ENOG4105G5W	regulator Fur family
APP_30220	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP_30260	ENOG4108IUW	ABC transporter
APP_30270	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
APP_30280	ENOG4107NBY	Membrane
APP_30300	ENOG4105BZ1	(ABC) transporter
APP_30310	ENOG4105EVI	UPF0374 protein
APP_30330	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
APP_30350	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
APP_30370	ENOG4105CEN	a g-specific adenine glycosylase
APP_30380	ENOG41067AE	Membrane-bound metal-dependent hydrolase
APP_30390	ENOG4105XHU	Acid-soluble spore protein K
APP_30420	ENOG410902V	Modulates RecA activity (By similarity)
APP_30490	ENOG4108ZCF	integral membrane protein
APP_30500	ENOG4107RSM	transcriptional regulator
APP_30520	ENOG4105DJB	Major Facilitator Superfamily
APP_30530	ENOG4105C0H	protease
APP_30550	ENOG4105CSV	Glutaminase
APP_30560	ENOG4105F27	Major Facilitator
APP_30570	ENOG4107RSM	transcriptional regulator
APP_30600	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APP_30610	ENOG4108JQ1	Dehydrogenase
APP_30630	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
APP_30640	ENOG4105C28	cystathionine
APP_30680	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
APP_30720	ENOG4107TXC	Transcriptional regulator
APP_30750	ENOG4105D2S	major facilitator superfamily
APP_30770	ENOG4105KK4	UPF0060 membrane protein
APP_30800	ENOG4107TE5	Lipid kinase
APP_30840	ENOG4105CPQ	Dehydrogenase
APP_30850	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
APP_30890	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
APP_30920	ENOG4105DQ6	Transposase
APP_31010	ENOG4105TPC	MazG nucleotide pyrophosphohydrolase domain
APP_31020	ENOG4108RZE	Tetr family transcriptional regulator
APP_31040	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
APP_31080	ENOG4105DG4	malate L-lactate dehydrogenase
APP_31090	ENOG4105DG4	malate L-lactate dehydrogenase
APP_31120	ENOG4105CTX	dehydratase
APP_31160	ENOG4105WH1	Two component transcriptional regulator luxr family
APP_31220	ENOG4105CJ1	ABC, transporter
APP_31250	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APP_31340	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_31350	ENOG4105WQI	isochorismatase
APP_31360	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
APP_31370	ENOG4105E4F	Isochorismate synthase
APP_31380	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
APP_31450	ENOG4105E5H	Transposase
APP_31490	ENOG4105CI1	PTS System
APP_31500	ENOG4105F8D	glycoside hydrolase family 4
APP_31510	ENOG4108Q3X	Transcriptional regulator
APP_31520	ENOG4105C5Y	PTS System
APP_31720	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
APP_31770	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
APP_31780	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
APP_31800	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
APP_31810	ENOG4107V49	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
APP_31820	ENOG4105JAS	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity)
APP_31830	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
APP_31930	ENOG4105UPD	Calcium Proton
APP_31950	ENOG4105ECB	domain protein
APP_32000	ENOG4107U9T	Pfam:Ribonuclease_BN
APP_32020	ENOG4105KJF	protein tyrosine phosphatase
APP_32030	ENOG41068PA	UPF0435 protein
APP_32090	ENOG4105DTQ	mandelate racemase muconate lactonizing
APP_32100	ENOG4105ES4	Nitrilase
APP_32150	ENOG4105C1G	acyl-Coa dehydrogenase
APP_32170	ENOG4105KVH	Transcriptional regulator
APP_32200	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APP_32210	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
APP_32220	ENOG4108IJG	ABC transporter substrate-binding protein
APP_32230	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
APP_32240	ENOG4105DRS	transport system, permease
APP_32250	ENOG4108IJ9	(ABC) transporter
APP_32280	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
APP_32320	ENOG4108IPW	abc transporter atp-binding protein
APP_32330	ENOG4105CM4	permease protein
APP_32340	ENOG4105DHS	permease protein
APP_32350	ENOG4108Z1Z	gCN5-related N-acetyltransferase
APP_32360	ENOG410667J	hydrolase
APP_32370	ENOG4105BZ1	(ABC) transporter
APP_32380	ENOG4105BZ1	(ABC) transporter
APP_32420	ENOG4107RUE	extracellular solute-binding protein family 1
APP_32430	ENOG4105D38	putrescine abc transporter
APP_32440	ENOG4105F38	ABC transporter, permease
APP_32450	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APP_32470	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
APP_32480	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
APP_32490	ENOG4105ETE	Transcriptional regulator (LacI family
APP_32500	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
APP_32510	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
APP_32520	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
APP_32550	ENOG4105CPQ	Dehydrogenase
APP_32580	ENOG4105BZU	Histidine kinase
APP_32600	ENOG4105ETD	TRANSCRIPTIONal
APP_32620	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
APP_32650	ENOG4105DWK	Membrane
APP_32660	ENOG4105YA8	Transcriptional regulator
APP_32670	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APP_32700	ENOG4107S91	Sodium hydrogen exchanger
APP_32710	ENOG4105NCW	Trka-c domain protein
APP_32740	ENOG4105C8Q	Methyl-accepting chemotaxis
APP_32750	ENOG4105CUB	amino acid
APP_32780	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
APP_32790	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
APP_32830	ENOG4105FB9	CRISPR-associated protein
APP_32860	ENOG41060BG	Tetr family transcriptional regulator
APP_32870	ENOG4105EAB	amino acid AbC transporter
APP_32880	ENOG4105E5Q	amino acid AbC transporter
APP_32890	ENOG4105CDA	abc transporter atp-binding protein
APP_32930	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
APP_32940	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
APP_32950	ENOG4105KFN	sortase, SrtB family
APP_32990	ENOG4106ST0	Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)
APP_33020	ENOG4105CDA	abc transporter atp-binding protein
APP_33040	ENOG4108K8K	Transcriptional regulator
APP_33050	ENOG4105DCF	alanine dehydrogenase
APP_33070	ENOG4105Z26	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity)
APP_33080	ENOG4105DWT	malate dehydrogenase (quinone)
APP_33090	ENOG41067SE	Tetr family transcriptional regulator
APP_33110	ENOG4105CSH	Transporter
APP_33130	ENOG4105CMU	LysR family (Transcriptional regulator
APP_33140	ENOG4105CRW	Short chain fatty acid transporter
APP_33370	ENOG4107QKV	phosphomannomutase
APP_33400	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
APP_33420	ENOG4105CBD	Diacylglycerol kinase
APP_33430	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
APP_33440	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
APP_33480	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
APP_33490	ENOG4105C4R	Atp-dependent dna helicase
APP_33500	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
APP_33510	ENOG4105KGF	protein, YerC YecD
APP_33520	ENOG4108R5T	secreted protein
APP_33540	ENOG4105C12	Phosphoribosylglycinamide synthetase
APP_33550	ENOG4105DC1	bifunctional purine biosynthesis protein purh
APP_33560	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
APP_33570	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
APP_33590	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
APP_33600	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
APP_33610	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
APP_33620	ENOG4105C8V	SAICAR synthetase
APP_33630	ENOG4105C83	adenylosuccinate lyase
APP_33640	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
APP_33650	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
APP_33660	ENOG4105C7N	Xanthine uracil vitamin C permease
APP_33680	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
APP_33710	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
APP_33790	ENOG4108SBK	dioxygenase, subunit beta
APP_33800	ENOG4105FUY	alpha subunit
APP_33810	ENOG4108IV0	ABC, transporter
APP_33820	ENOG4105C0Z	ABC transporter
APP_33830	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
APP_33840	ENOG4105C32	Amino acid ABC transporter (Permease)
APP_33870	ENOG4105C26	Dehydrogenase
APP_33890	ENOG4105C26	Dehydrogenase
APP_33920	ENOG4105ERH	Fumarylacetoacetate hydrolase
APP_33930	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
APP_33940	ENOG4105DTN	riboflavin biosynthesis protein ribF
APP_33990	ENOG4106P55	Transcriptional regulator
APP_34010	ENOG4105C5I	Dehydrogenase
APP_34020	ENOG4105CSH	Transporter
APP_34060	ENOG4105CPQ	Dehydrogenase
APP_34080	ENOG4105CPQ	Dehydrogenase
APP_34090	ENOG4105DT3	PTS system, galactitol-specific IIc component
APP_34100	ENOG4105K18	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
APP_34110	ENOG4105CTS	PTS system mannitol-specific
APP_34150	ENOG4105RWS	endonuclease I
APP_34160	ENOG41069FQ	Metallo-beta-lactamase superfamily
APP_34170	ENOG4108V06	Glutathione peroxidase
APP_34200	ENOG4105DZY	Pts system, glucitol sorbitol-specific
APP_34210	ENOG410787A	Pts system, glucitol sorbitol-specific
APP_34240	ENOG4105CHR	reductase
APP_34260	ENOG4105BZU	Histidine kinase
APP_34270	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APP_34310	ENOG4105CIG	ABC transporter
APP_34360	ENOG4105DA5	(ABC) transporter
APP_34380	ENOG410904A	RNA polymerase
APP_34390	ENOG4105CE4	GlcNAc 6-P deacetylase
APP_34440	ENOG4105C26	Dehydrogenase
APP_34450	ENOG4108JPW	Aminotransferase
APP_34480	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
APP_34520	ENOG4105CEY	Amp-dependent synthetase and ligase
APP_34530	ENOG4108Z7G	MaoC domain protein dehydratase
APP_34540	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
APP_34570	ENOG4105C0Z	ABC transporter
APP_34580	ENOG4108IV0	ABC, transporter
APP_34590	ENOG4105C32	Amino acid ABC transporter (Permease)
APP_34650	ENOG4108V7D	UPF0397 protein
APP_34680	ENOG4105CMR	udp-glucose 4-epimerase
APP_34710	ENOG4108TJN	glycosyl transferase group 1
APP_34800	ENOG4105D2T	synthase
APP_34850	ENOG4107TY6	Acylneuraminate cytidylyltransferase
APP_34860	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
APP_34870	ENOG4105C5E	polysaccharide biosynthesis protein
APP_34880	ENOG4105D3Q	Sugar transferase
APP_34890	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
APP_34900	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
APP_34910	ENOG4107YJ4	chain length determinant protein
APP_34920	ENOG4105HTX	biosynthesis protein
APP_34950	ENOG4105KBK	Zinc finger, swim domain protein
APP_34960	ENOG4105C0D	helicase
APP_34970	ENOG4105Z8H	single-stranded DNA-binding protein
APP_34990	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
APP_35040	ENOG4105CGA	flagellar basal-body rod protein FlgG
APP_35060	ENOG4105DFF	Rod shape-determining protein mreb
APP_35070	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
APP_35090	ENOG4105E7W	lamb ycsf family protein
APP_35100	ENOG4105P4J	Allophanate hydrolase, subunit 1
APP_35110	ENOG4107TCE	N-acetyltransferase
APP_35120	ENOG4105FRN	stage II sporulation protein
APP_35150	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
APP_35170	ENOG4106778	Protein of unknown function (DUF1146)
APP_35180	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
APP_35190	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
APP_35200	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
APP_35210	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
APP_35220	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APP_35230	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
APP_35240	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APP_35250	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
APP_35260	ENOG41062M3	atp synthase
APP_35280	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
APP_35290	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
APP_35300	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
APP_35320	ENOG4108YZG	isomerase
APP_35330	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
APP_35340	ENOG4107WAU	Protein tyrosine phosphatase
APP_35350	ENOG410815N	Probably functions as a manganese efflux pump (By similarity)
APP_35360	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APP_35380	ENOG4108ZXQ	stage ii sporulation protein r
APP_35390	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
APP_35400	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
APP_35440	ENOG4107104	thymidine kinase
APP_35450	ENOG41082DI	50s ribosomal protein l31
APP_35460	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
APP_35470	ENOG4105CBT	Fructose-1,6-bisphosphatase
APP_35480	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
APP_35490	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
APP_35500	ENOG4105D2N	Aldolase
APP_35510	ENOG410812K	response regulator receiver protein
APP_35540	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
APP_35560	ENOG4105DF6	Fe-S oxidoreductase
APP_35570	ENOG4105EMN	RNA polymerase sigma factor
APP_35580	ENOG4105C75	arginyL-tRNA synthetase
APP_35590	ENOG410684U	Domain of unknown function (DUF1934)
APP_35600	ENOG4105CYW	agmatinase
APP_35610	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
APP_35620	ENOG4105BZ4	penicillin-binding protein
APP_35630	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
APP_35640	ENOG4108QCI	YvbH-like oligomerisation region
APP_35650	ENOG4108VCI	transcription factor, rsfa family
APP_35660	ENOG4105QAT	UPF0741 protein
APP_35670	ENOG4105DCI	Phosphohydrolase
APP_35690	ENOG4108Z4T	Peptidase M50
APP_35700	ENOG4108XFG	YwhD family
APP_35720	ENOG4108IJ2	phosphate acetyltransferase
APP_35730	ENOG4107JTW	chlorite dismutase
APP_35740	ENOG4108VKI	Cell wall hydrolase
APP_35760	ENOG4107RQ2	Cytochrome c oxidase, subunit I
APP_35770	ENOG4105NAA	Cytochrome C oxidase, subunit II
APP_35810	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
APP_35840	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
APP_35870	ENOG4108IG5	Transcriptional regulator
APP_35880	ENOG4105DWF	phosphomethylpyrimidine kinase
APP_35890	ENOG4105DAP	Nicotinate phosphoribosyltransferase
APP_35900	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
APP_35920	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
APP_35930	ENOG41060D1	Quinol oxidase
APP_35960	ENOG4105E2S	oxidase) subunit II
APP_35970	ENOG4108DBC	nitroreductase
APP_35980	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
APP_36000	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
APP_36010	ENOG4106PMH	Extracellular solute-binding protein family 3
APP_36020	ENOG4105E5Q	amino acid AbC transporter
APP_36050	ENOG4108X4Q	Hydrolase
APP_36060	ENOG4107YBY	Hydrolase
APP_36110	ENOG4108IV0	ABC, transporter
APP_36120	ENOG4105C0Z	ABC transporter
APP_36140	ENOG4105C32	Amino acid ABC transporter (Permease)
APP_36150	ENOG4105CAD	extracellular ligand-binding receptor
APP_36160	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
APP_36180	ENOG4105CNN	ABC, transporter
APP_36190	ENOG4105C2J	ABC transporter
APP_36200	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
APP_36220	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
APP_36230	ENOG4105ETE	Transcriptional regulator (LacI family
APP_36250	ENOG4105C7S	Dehydrogenase
APP_36260	ENOG4105CPP	Dehydrogenase, E1 component
APP_36270	ENOG4107RUY	(E1 component), alpha subunit
APP_36370	ENOG4107T9Q	phosphonate abc transporter
APP_36380	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
APP_36420	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
APP_36460	ENOG4105CJZ	response regulator
APP_36470	ENOG4105EWM	Histidine kinase
APP_36480	ENOG4105C19	ABC transporter
APP_36490	ENOG4108HVR	ABC transporter, permease
APP_36500	ENOG4108RYK	Nad-dependent epimerase dehydratase
APP_36510	ENOG4108Z40	Transcriptional regulator
APP_36570	ENOG4105CTS	PTS system mannitol-specific
APP_36590	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
APP_36600	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
APP_36610	ENOG41080HJ	6-phospho 3-hexuloisomerase
APP_36620	ENOG4105DJV	ribulose-phosphate 3-epimerase
APP_36630	ENOG4105E98	transcriptional regulator DeoR family
APP_36660	ENOG4105CJ1	ABC, transporter
APP_36670	ENOG4105E1J	oxidoreductase
APP_36690	ENOG4108S4H	thioesterase Superfamily protein
APP_36710	ENOG4105CMU	LysR family (Transcriptional regulator
APP_36750	ENOG4105EEM	helicase
APP_36800	ENOG4105DAA	L-lactate
APP_36900	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
APP_36920	ENOG4105C0H	protease
APP_36930	ENOG4105Q2H	domain protein
APP_36960	ENOG4105BZU	Histidine kinase
APP_36970	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APP_36980	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
APP_36990	ENOG4105CDU	Replicative dna helicase
APP_37000	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
APP_37010	ENOG4105BZR	domain protein
APP_37020	ENOG4108XMW	Membrane
APP_37030	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
APP_37040	ENOG4108UUM	single-stranded DNA-binding protein
APP_37050	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
APP_37060	ENOG4105C3G	gtp-binding protein
APP_37070	ENOG4105VDK	protein, conserved in bacteria
APP_37080	ENOG4108ZDA	Sporulation protein YyaC
APP_37090	ENOG4105FA0	parb-like partition protein
APP_37100	ENOG4107QJE	Chromosome Partitioning Protein
APP_37110	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
APP_37120	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
APP_37130	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
APP_37140	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
APP_37160	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APP_37170	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
APP_37180	ENOG4105VG0	50S ribosomal protein l34