locus-tag	class	description
APP_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APP_00030	COG0592	DNA-directed DNA polymerase activity
APP_00040	COG2501	S4 domain
APP_00050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APP_00060	COG0187	DNA topoisomerase II activity
APP_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP_00100	COG0516	GMP reductase activity
APP_00100	COG0517	IMP dehydrogenase activity
APP_00120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
APP_00130	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
APP_00140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APP_00150	COG0579	oxidoreductase
APP_00160	COG1388	LysM domain
APP_00160	COG3858	chitin binding
APP_00170	COG0590	tRNA wobble adenosine to inosine editing
APP_00180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APP_00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APP_00250	COG1982	Orn Lys Arg decarboxylase major
APP_00260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APP_00270	COG3870	Protein conserved in bacteria
APP_00280	COG1728	Protein conserved in bacteria
APP_00290	COG0470	DNA polymerase III
APP_00300	COG1774	PSP1 C-terminal conserved region
APP_00310	COG4467	Involved in initiation control of chromosome replication
APP_00320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APP_00330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APP_00340	COG2002	toxin-antitoxin pair type II binding
APP_00360	COG0084	hydrolase, TatD family'
APP_00370	COG3584	3D domain protein
APP_00370	COG3583	domain protein
APP_00380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APP_00390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APP_00410	COG4466	Protein conserved in bacteria
APP_00430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APP_00440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APP_00450	COG0251	oxidation-reduction process
APP_00460	COG2088	sporulation resulting in formation of a cellular spore
APP_00470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APP_00480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APP_00490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APP_00500	COG0193	aminoacyl-tRNA hydrolase activity
APP_00520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APP_00530	COG2002	toxin-antitoxin pair type II binding
APP_00540	COG2244	polysaccharide biosynthetic process
APP_00550	COG3956	TIGRFAM MazG family protein
APP_00560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APP_00580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APP_00590	COG1098	S1 RNA binding domain
APP_00600	COG2208	phosphoserine phosphatase activity
APP_00610	COG2304	oxidoreductase activity
APP_00620	COG0515	serine threonine protein kinase
APP_00630	COG0037	tRNA processing
APP_00650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APP_00660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APP_00670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APP_00680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP_00690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APP_00700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APP_00710	COG0512	Glutamine amidotransferase of anthranilate synthase
APP_00720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP_00730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APP_00740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APP_00750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APP_00760	COG1396	sequence-specific DNA binding
APP_00770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP_00780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APP_00860	COG1131	(ABC) transporter
APP_00890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APP_00960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APP_01010	COG1285	pathogenesis
APP_01030	COG3880	PFAM UvrB UvrC protein
APP_01040	COG3869	Catalyzes the specific phosphorylation of arginine residues in
APP_01050	COG0542	response to heat
APP_01060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APP_01070	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
APP_01080	COG4956	integral membrane protein (PIN domain superfamily)
APP_01090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APP_01100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APP_01110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APP_01120	COG1045	serine acetyltransferase
APP_01130	COG0215	cysteine-tRNA ligase activity
APP_01140	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APP_01150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP_01160	COG3688	RNA-binding protein containing a PIN domain
APP_01180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP_01190	COG0250	Participates in transcription elongation, termination and antitermination
APP_01200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APP_01210	COG0081	regulation of translation
APP_01220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APP_01230	COG0222	ribosome binding
APP_01240	COG2813	Specifically methylates the guanine in position
APP_01250	COG0085	RNA polymerase activity
APP_01260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APP_01270	COG1358	cellular component organization or biogenesis
APP_01280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APP_01290	COG0049	tRNA binding
APP_01300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APP_01310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APP_01320	COG0051	transcription antitermination factor activity, RNA binding
APP_01330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APP_01340	COG0088	Forms part of the polypeptide exit tunnel
APP_01350	COG0089	rRNA binding
APP_01360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APP_01370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APP_01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APP_01390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APP_01410	COG0255	Belongs to the universal ribosomal protein uL29 family
APP_01420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APP_01430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APP_01450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APP_01460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APP_01470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APP_01490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APP_01500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APP_01520	COG0200	Binds to the 23S rRNA
APP_01530	COG0201	protein transport
APP_01540	COG0563	adenylate kinase activity
APP_01550	COG0024	Methionine aminopeptidase
APP_01560	COG2163	COG2163 Ribosomal protein L14E L6E L27E
APP_01570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APP_01580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APP_01590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APP_01610	COG0203	ribosomal protein L17
APP_01620	COG1122	ATPase activity
APP_01630	COG1122	ATPase activity
APP_01640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APP_01650	COG0101	tRNA pseudouridine synthase activity
APP_01660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APP_01670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APP_01700	COG0860	N-Acetylmuramoyl-L-alanine amidase
APP_01710	COG0489	protein tyrosine kinase activity
APP_01730	COG2194	sulfuric ester hydrolase activity
APP_01740	COG0726	polysaccharide deacetylase
APP_01770	COG1595	DNA-templated transcription, initiation
APP_01780	COG5662	AntiSigma factor
APP_01790	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APP_01800	COG4856	YbbR-like protein
APP_01810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APP_01820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APP_01850	COG0531	amino acid
APP_01880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APP_01890	COG1263	PTS System
APP_01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_01910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APP_01920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APP_01930	COG0363	glucosamine-6-phosphate deaminase activity
APP_01940	COG2188	Transcriptional regulator
APP_02050	COG3328	transposase activity
APP_02060	COG0789	Transcriptional regulator
APP_02070	COG1253	flavin adenine dinucleotide binding
APP_02130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP_02140	COG0446	pyridine nucleotide-disulphide oxidoreductase
APP_02140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APP_02200	COG1349	DNA-binding transcription factor activity
APP_02220	COG3414	Phosphotransferase system galactitol-specific IIB component
APP_02230	COG3775	system Galactitol-specific IIC component
APP_02240	COG1063	alcohol dehydrogenase
APP_02250	COG3684	Belongs to the aldolase LacD family
APP_02260	COG1113	amino acid transport
APP_02270	COG0583	DNA-binding transcription factor activity
APP_02280	COG2070	2-Nitropropane dioxygenase
APP_02310	COG0277	FAD linked oxidase domain protein
APP_02320	COG0247	lactate metabolic process
APP_02330	COG0277	FAD linked oxidase domain protein
APP_02340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APP_02360	COG1414	Transcriptional regulator
APP_02370	COG1620	l-lactate permease
APP_02380	COG1937	Protein conserved in bacteria
APP_02390	COG0534	Mate efflux family protein
APP_02410	COG0765	amino acid transport
APP_02420	COG1126	abc transporter atp-binding protein
APP_02460	COG2076	Multidrug Resistance protein
APP_02470	COG2076	Multidrug Resistance protein
APP_02490	COG4806	L-rhamnose isomerase
APP_02500	COG1070	Carbohydrate kinase
APP_02510	COG0588	phosphoglycerate mutase activity
APP_02530	COG2972	Histidine kinase
APP_02540	COG2207	Transcriptional regulator
APP_02550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APP_02560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP_02570	COG1129	ABC transporter
APP_02580	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP_02600	COG1879	ABC-type sugar transport system periplasmic component
APP_02610	COG1070	Carbohydrate kinase
APP_02630	COG1413	lyase activity
APP_02640	COG1131	(ABC) transporter
APP_02650	COG1266	CAAX protease self-immunity
APP_02660	COG0535	radical SAM domain protein
APP_02690	COG2814	Major facilitator Superfamily
APP_02720	COG3832	glyoxalase III activity
APP_02750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APP_02770	COG1472	Belongs to the glycosyl hydrolase 3 family
APP_02800	COG1114	Component of the transport system for branched-chain amino acids
APP_02850	COG0431	NADPH-dependent FMN reductase
APP_02880	COG1960	acyl-CoA dehydrogenase activity
APP_02890	COG1960	acyl-CoA dehydrogenase activity
APP_02910	COG2011	ABC-type metal ion transport system permease component
APP_02940	COG0667	Aldo Keto reductase
APP_02950	COG1960	acyl-CoA dehydrogenase activity
APP_02960	COG1960	acyl-CoA dehydrogenase activity
APP_02970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP_02980	COG2078	PFAM AMMECR1 domain protein
APP_02980	COG3885	ferrous iron binding
APP_03010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APP_03070	COG0483	inositol monophosphate 1-phosphatase activity
APP_03080	COG2186	Transcriptional regulator
APP_03090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APP_03100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APP_03120	COG0784	Response regulator, receiver
APP_03130	COG4191	Histidine kinase
APP_03140	COG0765	amino acid transport
APP_03150	COG0765	amino acid transport
APP_03220	COG0693	protein deglycase activity
APP_03230	COG3104	oligopeptide transport
APP_03250	COG3104	oligopeptide transport
APP_03260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP_03270	COG0702	epimerase
APP_03280	COG2807	transmembrane transport
APP_03320	COG1136	(ABC) transporter
APP_03330	COG0577	efflux transmembrane transporter activity
APP_03340	COG0745	RESPONSE REGULATOR receiver
APP_03350	COG5002	protein histidine kinase activity
APP_03350	COG3850	Histidine kinase
APP_03360	COG2514	catechol 2,3-dioxygenase activity
APP_03390	COG0069	glutamate synthase activity
APP_03400	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APP_03410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP_03420	COG1011	Hydrolase
APP_03430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_03440	COG1181	Belongs to the D-alanine--D-alanine ligase family
APP_03450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APP_03460	COG0513	Belongs to the DEAD box helicase family
APP_03470	COG3402	PFAM membrane-flanked domain
APP_03480	COG3428	Bacterial PH domain
APP_03490	COG0705	Rhomboid family
APP_03500	COG0736	holo-[acyl-carrier-protein] synthase activity
APP_03510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APP_03530	COG0864	Transcriptional regulator
APP_03540	COG2337	Toxic component of a toxin-antitoxin (TA) module
APP_03550	COG1366	Belongs to the anti-sigma-factor antagonist family
APP_03560	COG1366	Belongs to the anti-sigma-factor antagonist family
APP_03570	COG2172	sigma factor antagonist activity
APP_03580	COG2208	phosphoserine phosphatase activity
APP_03590	COG1366	Belongs to the anti-sigma-factor antagonist family
APP_03610	COG1191	sigma factor activity
APP_03620	COG2208	phosphoserine phosphatase activity
APP_03630	COG2183	response to ionizing radiation
APP_03640	COG3091	SprT-like family
APP_03650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APP_03660	COG0802	atpase or kinase
APP_03670	COG1214	PFAM Peptidase M22, glycoprotease
APP_03680	COG0456	acetyltransferase
APP_03690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APP_03700	COG0488	(ABC) transporter
APP_03710	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APP_03720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP_03730	COG0805	protein transport
APP_03750	COG1266	CAAX protease self-immunity
APP_03760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APP_03770	COG0459	protein refolding
APP_03780	COG4974	Belongs to the 'phage' integrase family
APP_03950	COG1136	(ABC) transporter
APP_03980	COG3739	integral membrane protein
APP_04010	COG4372	Transposase
APP_04020	COG3655	Transcriptional regulator
APP_04070	COG1082	Xylose isomerase domain protein TIM barrel
APP_04090	COG0501	Belongs to the peptidase M48B family
APP_04180	COG1349	DNA-binding transcription factor activity
APP_04190	COG1012	belongs to the aldehyde dehydrogenase family
APP_04200	COG3718	enzyme involved in inositol metabolism
APP_04210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP_04220	COG3962	Belongs to the TPP enzyme family
APP_04230	COG1082	Xylose isomerase domain protein TIM barrel
APP_04240	COG2814	Major facilitator Superfamily
APP_04250	COG0673	inositol 2-dehydrogenase activity
APP_04260	COG1082	Xylose isomerase domain protein TIM barrel
APP_04270	COG1082	Xylose isomerase domain protein TIM barrel
APP_04280	COG0191	fructose-bisphosphate aldolase activity
APP_04300	COG1082	Xylose isomerase domain protein TIM barrel
APP_04310	COG0667	Aldo Keto reductase
APP_04330	COG0673	inositol 2-dehydrogenase activity
APP_04350	COG1129	ABC transporter
APP_04360	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP_04390	COG0191	fructose-bisphosphate aldolase activity
APP_04430	COG0247	lactate metabolic process
APP_04440	COG0277	FAD linked oxidase domain protein
APP_04450	COG2186	Transcriptional regulator
APP_04470	COG1012	belongs to the aldehyde dehydrogenase family
APP_04480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APP_04510	COG0409	Hydrogenase expression formation protein
APP_04520	COG0298	carbon dioxide binding
APP_04620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APP_04630	COG0375	protein maturation
APP_04650	COG2188	Transcriptional regulator
APP_04690	COG3627	carbon phosphorus lyase activity
APP_04700	COG4107	phosphonate C-P lyase system protein PhnK
APP_04710	COG3454	Phosphonate metabolism
APP_04730	COG4778	phosphonate C-P lyase system protein PhnL
APP_04750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APP_04760	COG3639	organic phosphonate transmembrane transporter activity
APP_04770	COG3639	organic phosphonate transmembrane transporter activity
APP_04780	COG0613	PHP domain protein
APP_04810	COG1131	(ABC) transporter
APP_04870	COG1131	(ABC) transporter
APP_04900	COG0697	spore germination
APP_04910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APP_04940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APP_05000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APP_05010	COG0022	dehydrogenase e1 component
APP_05020	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_05030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APP_05040	COG0303	'Molybdopterin
APP_05060	COG0803	Belongs to the bacterial solute-binding protein 9 family
APP_05070	COG1121	(ABC) transporter
APP_05080	COG1321	iron dependent repressor
APP_05080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP_05090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP_05100	COG1321	iron dependent repressor
APP_05120	COG3764	Sortase (surface protein transpeptidase)
APP_05130	COG1113	amino acid transport
APP_05140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP_05140	COG4499	WXG100 protein secretion system (Wss), protein YukC
APP_05150	COG1737	Transcriptional regulator
APP_05160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP_05160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP_05160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_05170	COG0383	alpha-mannosidase activity
APP_05180	COG1929	Belongs to the glycerate kinase type-1 family
APP_05190	COG1482	cell wall glycoprotein biosynthetic process
APP_05240	COG3730	PTS system glucitol sorbitol-specific
APP_05250	COG3732	PTS system glucitol sorbitol-specific
APP_05270	COG2390	Transcriptional regulator
APP_05280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APP_05290	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_05290	COG0022	dehydrogenase e1 component
APP_05300	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_05310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP_05320	COG2390	Transcriptional regulator
APP_05330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_05340	COG3414	Phosphotransferase system galactitol-specific IIB component
APP_05350	COG3775	system Galactitol-specific IIC component
APP_05370	COG3290	protein histidine kinase activity
APP_05380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APP_05390	COG1301	dicarboxylic acid transport
APP_05400	COG1482	cell wall glycoprotein biosynthetic process
APP_05430	COG1316	TRANSCRIPTIONal
APP_05450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APP_05460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APP_05480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
APP_05490	COG1682	transport, permease protein
APP_05500	COG1134	teichoic acid transport
APP_05510	COG4193	domain, Protein
APP_05550	COG0728	peptidoglycan biosynthetic process
APP_05570	COG0438	transferase activity, transferring glycosyl groups
APP_05580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APP_05590	COG0438	transferase activity, transferring glycosyl groups
APP_05600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APP_05610	COG1316	TRANSCRIPTIONal
APP_05620	COG1739	Uncharacterized protein family UPF0029
APP_05630	COG4585	Histidine kinase
APP_05640	COG2197	response regulator
APP_05650	COG1307	EDD domain protein, DegV family
APP_05660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APP_05680	COG1040	competence protein
APP_05720	COG4786	Flagellar basal body rod
APP_05720	COG1256	bacterial-type flagellum assembly
APP_05730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APP_05750	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
APP_05760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APP_05770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APP_05780	COG3344	reverse transcriptase
APP_05810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APP_05870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APP_05880	COG2089	acid synthase
APP_05900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APP_05960	COG2186	Transcriptional regulator
APP_05980	COG2801	Transposase and inactivated derivatives
APP_06000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APP_06010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APP_06030	COG2814	Major facilitator Superfamily
APP_06040	COG0604	alcohol dehydrogenase
APP_06070	COG1309	transcriptional regulator
APP_06110	COG1388	LysM domain
APP_06110	COG3584	3D domain protein
APP_06130	COG0670	Belongs to the BI1 family
APP_06140	COG3290	protein histidine kinase activity
APP_06140	COG3829	transcription factor binding
APP_06150	COG1454	alcohol dehydrogenase
APP_06170	COG1012	belongs to the aldehyde dehydrogenase family
APP_06180	COG5504	Zn-dependent protease
APP_06190	COG2814	Major facilitator Superfamily
APP_06210	COG3711	transcriptional antiterminator
APP_06230	COG3711	transcriptional antiterminator
APP_06240	COG2723	6-phospho-beta-galactosidase activity
APP_06250	COG2723	6-phospho-beta-galactosidase activity
APP_06260	COG2190	(PTS) system
APP_06260	COG1263	PTS System
APP_06260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_06270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP_06280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_06290	COG1116	anion transmembrane transporter activity
APP_06300	COG5278	phosphoserine phosphatase activity
APP_06300	COG0840	transmembrane signaling receptor activity
APP_06320	COG3665	Urea carboxylase-associated protein
APP_06330	COG0439	Biotin carboxylase
APP_06390	COG4152	abc transporter atp-binding protein
APP_06400	COG1668	transmembrane transport
APP_06410	COG0840	transmembrane signaling receptor activity
APP_06420	COG1028	Short-chain dehydrogenase reductase Sdr
APP_06420	COG3347	Dehydrogenase
APP_06430	COG1349	DNA-binding transcription factor activity
APP_06440	COG4154	Belongs to the RbsD FucU family
APP_06450	COG1070	Carbohydrate kinase
APP_06460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APP_06470	COG1129	ABC transporter
APP_06480	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP_06500	COG0235	Class ii aldolase
APP_06510	COG1070	Carbohydrate kinase
APP_06530	COG1069	ribulokinase activity
APP_06540	COG0183	Belongs to the thiolase family
APP_06550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APP_06560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APP_06570	COG0583	DNA-binding transcription factor activity
APP_06580	COG0145	ligase activity
APP_06590	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
APP_06600	COG4647	ligase activity
APP_06630	COG4585	Histidine kinase
APP_06640	COG2197	response regulator
APP_06650	COG1131	(ABC) transporter
APP_06680	COG1132	(ABC) transporter
APP_06700	COG2814	Major facilitator Superfamily
APP_06740	COG3842	ATPase activity
APP_06750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APP_06780	COG1442	glycosyl transferase family 8
APP_06790	COG2508	Transcriptional regulator
APP_06800	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP_06810	COG1024	Enoyl-CoA hydratase
APP_06820	COG0318	PFAM AMP-dependent synthetase and ligase
APP_06850	COG1960	acyl-CoA dehydrogenase activity
APP_06870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP_06890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
APP_06920	COG0179	Fumarylacetoacetate (FAA) hydrolase
APP_06970	COG1334	flagellar protein FlaG
APP_06980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APP_06990	COG1516	flagellar protein fliS
APP_07010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APP_07020	COG0653	protein targeting
APP_07030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APP_07040	COG2010	Cytochrome c
APP_07050	COG2884	Cell division ATP-binding protein ftsE
APP_07060	COG2177	Part of the ABC transporter FtsEX involved in
APP_07070	COG0739	heme binding
APP_07080	COG3409	Peptidoglycan-binding domain 1 protein
APP_07080	COG0793	Belongs to the peptidase S41A family
APP_07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP_07100	COG2072	flavoprotein involved in K transport
APP_07120	COG0640	Transcriptional regulator
APP_07160	COG1940	carbohydrate kinase activity
APP_07180	COG0556	nucleotide-excision repair
APP_07190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APP_07210	COG1960	acyl-CoA dehydrogenase activity
APP_07220	COG1126	abc transporter atp-binding protein
APP_07230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
APP_07240	COG0765	amino acid transport
APP_07250	COG0765	amino acid transport
APP_07280	COG1950	PFAM Membrane protein of
APP_07290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APP_07300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APP_07310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APP_07320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APP_07330	COG0546	phosphoglycolate phosphatase activity
APP_07340	COG0110	maltose O-acetyltransferase activity
APP_07350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APP_07360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APP_07370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APP_07380	COG0131	Imidazoleglycerol-phosphate dehydratase
APP_07390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APP_07400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APP_07410	COG0107	imidazoleglycerol-phosphate synthase activity
APP_07420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APP_07420	COG0140	phosphoribosyl-ATP diphosphatase activity
APP_07430	COG0457	Tetratricopeptide repeat
APP_07440	COG0492	ferredoxin-NADP+ reductase activity
APP_07450	COG1051	belongs to the nudix hydrolase family
APP_07460	COG1660	Displays ATPase and GTPase activities
APP_07470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APP_07480	COG1481	regulation of sporulation
APP_07490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_07500	COG0740	serine-type endopeptidase activity
APP_07520	COG3279	Response regulator of the LytR AlgR family
APP_07530	COG0427	acetyl-CoA hydrolase
APP_07540	COG1929	Belongs to the glycerate kinase type-1 family
APP_07550	COG1737	Transcriptional regulator
APP_07560	COG1486	melibiose metabolic process
APP_07600	COG1518	maintenance of DNA repeat elements
APP_07610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APP_07650	COG4372	Transposase
APP_07700	COG1353	crispr-associated protein
APP_07720	COG1337	RAMP superfamily
APP_07810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_07840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APP_07880	COG0126	phosphoglycerate kinase activity
APP_07910	COG0148	phosphopyruvate hydratase activity
APP_07930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP_07940	COG1647	Serine aminopeptidase, S33
APP_07950	COG0557	exoribonuclease II activity
APP_07960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APP_07990	COG0577	efflux transmembrane transporter activity
APP_08030	COG1116	anion transmembrane transporter activity
APP_08060	COG0788	formyltetrahydrofolate deformylase activity
APP_08070	COG0789	Transcriptional regulator
APP_08080	COG0114	fumarate hydratase activity
APP_08100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_08110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_08120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_08130	COG1120	ATPase activity
APP_08160	COG5577	PFAM Coat F domain
APP_08180	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP_08180	COG1024	Enoyl-CoA hydratase
APP_08190	COG0183	Belongs to the thiolase family
APP_08200	COG1960	acyl-CoA dehydrogenase activity
APP_08210	COG1393	Belongs to the ArsC family
APP_08220	COG0509	glycine decarboxylation via glycine cleavage system
APP_08230	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APP_08240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_08260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APP_08270	COG2011	ABC-type metal ion transport system permease component
APP_08280	COG1464	Belongs to the NlpA lipoprotein family
APP_08300	COG0396	ATPase activity
APP_08310	COG0719	Fe-S assembly protein
APP_08320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APP_08330	COG0822	iron-sulfur transferase activity
APP_08340	COG0719	Fe-S assembly protein
APP_08360	COG1801	Protein of unknown function DUF72
APP_08370	COG0737	Belongs to the 5'-nucleotidase family
APP_08380	COG3377	Domain of unknown function (DUF1805)
APP_08390	COG0739	heme binding
APP_08400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APP_08420	COG4470	Protein conserved in bacteria
APP_08450	COG2445	Protein of unknown function DUF86
APP_08460	COG0647	UMP catabolic process
APP_08470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APP_08480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APP_08490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APP_08500	COG0460	homoserine dehydrogenase
APP_08510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APP_08520	COG0083	homoserine kinase activity
APP_08530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APP_08540	COG4837	Protein of unknown function (DUF1462)
APP_08550	COG1252	NADH dehydrogenase
APP_08570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APP_08580	COG0316	Belongs to the HesB IscA family
APP_08590	COG0492	ferredoxin-NADP+ reductase activity
APP_08600	COG1252	NADH dehydrogenase
APP_08640	COG3584	3D domain protein
APP_08650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APP_08660	COG0686	Belongs to the AlaDH PNT family
APP_08670	COG1418	mRNA catabolic process
APP_08720	COG0142	geranyltranstransferase activity
APP_08740	COG4585	Histidine kinase
APP_08750	COG2197	response regulator
APP_08760	COG1320	monovalent cation:proton antiporter activity
APP_08770	COG2212	antiporter activity
APP_08780	COG1863	multisubunit Na H antiporter MnhE subunit
APP_08790	COG0651	ATP synthesis coupled electron transport
APP_08800	COG1006	Multisubunit Na H antiporter MnhC subunit
APP_08810	COG2111	Na H antiporter
APP_08820	COG2111	Na H antiporter
APP_08820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APP_08840	COG5018	Exonuclease
APP_08870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APP_08890	COG2267	carboxylic ester hydrolase activity
APP_08900	COG1522	sequence-specific DNA binding
APP_08910	COG0436	Aminotransferase
APP_08920	COG1098	S1 RNA binding domain
APP_08930	COG2155	Conserved Protein
APP_08940	COG0166	Belongs to the GPI family
APP_08960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APP_08980	COG2738	Putative neutral zinc metallopeptidase
APP_08990	COG0432	Pfam Uncharacterised protein family UPF0047
APP_09020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APP_09030	COG1575	Belongs to the MenA family. Type 1 subfamily
APP_09040	COG1169	isochorismate synthase
APP_09060	COG0596	Alpha beta hydrolase
APP_09070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APP_09080	COG0318	PFAM AMP-dependent synthetase and ligase
APP_09100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APP_09110	COG1854	S-ribosylhomocysteine lyase activity
APP_09120	COG0783	Belongs to the Dps family
APP_09140	COG0494	nUDIX hydrolase
APP_09150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_09160	COG1116	anion transmembrane transporter activity
APP_09170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP_09180	COG1506	peptidase
APP_09230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APP_09240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APP_09260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APP_09270	COG2267	carboxylic ester hydrolase activity
APP_09290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APP_09300	COG1242	4 iron, 4 sulfur cluster binding
APP_09330	COG1725	Transcriptional regulator
APP_09340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APP_09350	COG0495	leucyl-tRNA aminoacylation
APP_09360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP_09380	COG1648	precorrin-2 dehydrogenase activity
APP_09380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APP_09410	COG2081	HI0933 family
APP_09420	COG2244	polysaccharide biosynthetic process
APP_09430	COG1187	pseudouridine synthase activity
APP_09440	COG1349	DNA-binding transcription factor activity
APP_09500	COG2252	PERMEase
APP_09510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APP_09520	COG2076	Multidrug Resistance protein
APP_09530	COG2076	Multidrug Resistance protein
APP_09540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APP_09560	COG1380	Effector of murein hydrolase LrgA
APP_09570	COG1346	cytolysis
APP_09590	COG0510	thiamine kinase activity
APP_09610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APP_09620	COG0010	Belongs to the arginase family
APP_09630	COG5584	Small secreted protein
APP_09640	COG1363	Peptidase, m42
APP_09650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
APP_09660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_09670	COG4848	Belongs to the UPF0354 family
APP_09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APP_09690	COG1288	antiporter activity
APP_09700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APP_09710	COG2224	Isocitrate lyase
APP_09730	COG4903	ComK protein
APP_09750	COG0398	Pfam SNARE associated Golgi protein
APP_09760	COG0681	Belongs to the peptidase S26 family
APP_09770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APP_09780	COG1074	ATP-dependent DNA helicase activity
APP_09790	COG0420	3'-5' exonuclease activity
APP_09800	COG0419	ATPase involved in DNA repair
APP_09870	COG1959	2 iron, 2 sulfur cluster binding
APP_09880	COG5583	Uncharacterized small protein (DUF2292)
APP_09890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APP_09900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APP_09910	COG4208	sulfate ABC transporter
APP_09930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP_09940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP_09950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_09960	COG1116	anion transmembrane transporter activity
APP_09990	COG0084	hydrolase, TatD family'
APP_10000	COG0179	Fumarylacetoacetate (FAA) hydrolase
APP_10050	COG1131	(ABC) transporter
APP_10080	COG0367	asparagine synthase
APP_10120	COG2706	6-phosphogluconolactonase activity
APP_10130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APP_10140	COG1131	(ABC) transporter
APP_10180	COG1028	Short-chain dehydrogenase reductase Sdr
APP_10210	COG1132	(ABC) transporter
APP_10230	COG4555	ABC transporter
APP_10270	COG1410	methionine synthase
APP_10270	COG0646	methionine synthase
APP_10280	COG0646	methionine synthase
APP_10280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APP_10290	COG1666	GTP binding
APP_10320	COG1307	EDD domain protein, DegV family
APP_10340	COG0561	phosphatase activity
APP_10350	COG1073	alpha beta
APP_10360	COG2151	metal-sulfur cluster biosynthetic enzyme
APP_10370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APP_10380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APP_10410	COG0505	Belongs to the CarA family
APP_10420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APP_10430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APP_10470	COG2267	carboxylic ester hydrolase activity
APP_10490	COG1744	ABC transporter substrate-binding protein PnrA-like
APP_10510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP_10520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APP_10530	COG5504	Zn-dependent protease
APP_10560	COG0180	Tryptophanyl-tRNA synthetase
APP_10580	COG1393	Belongs to the ArsC family
APP_10590	COG0861	Integral membrane protein TerC family
APP_10600	COG4862	establishment of competence for transformation
APP_10610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APP_10620	COG4469	Competence protein
APP_10630	COG1164	Oligoendopeptidase f
APP_10650	COG2346	COG2346, Truncated hemoglobins
APP_10660	COG0741	lytic transglycosylase activity
APP_10670	COG4116	CYTH
APP_10690	COG2357	RelA SpoT domain protein
APP_10710	COG0564	pseudouridine synthase activity
APP_10720	COG2239	Acts as a magnesium transporter
APP_10730	COG0475	glutathione-regulated potassium exporter activity
APP_10730	COG0569	domain protein
APP_10740	COG0352	thiamine-phosphate diphosphorylase activity
APP_10750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APP_10760	COG2104	thiamine diphosphate biosynthetic process
APP_10770	COG2022	thiamine diphosphate biosynthetic process
APP_10780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APP_10790	COG0351	phosphomethylpyrimidine kinase
APP_10800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APP_10900	COG2323	membrane
APP_10910	COG2153	protein acetylation
APP_10920	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APP_10930	COG2382	esterase
APP_10960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP_10980	COG0626	cystathionine gamma-synthase activity
APP_10990	COG0626	cystathionine gamma-synthase activity
APP_11000	COG2358	TRAP transporter, solute receptor (TAXI family
APP_11110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APP_11130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APP_11190	COG1024	Enoyl-CoA hydratase
APP_11200	COG0477	Major facilitator Superfamily
APP_11290	COG4372	Transposase
APP_11360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_11360	COG1263	PTS System
APP_11370	COG0366	Alpha amylase catalytic
APP_11380	COG2188	Transcriptional regulator
APP_11430	COG4372	Transposase
APP_11450	COG1609	Transcriptional regulator
APP_11460	COG1263	PTS System
APP_11460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_11470	COG1621	beta-fructofuranosidase activity
APP_11480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP_11510	COG2076	Multidrug Resistance protein
APP_11520	COG2175	clavaminate synthase activity
APP_11530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APP_11540	COG4521	taurine ABC transporter
APP_11550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_11570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APP_11580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APP_11610	COG0701	Predicted permease
APP_11630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APP_11630	COG0456	acetyltransferase
APP_11640	COG0717	Belongs to the dCTP deaminase family
APP_11650	COG0523	cobalamin synthesis protein
APP_11690	COG0693	protein deglycase activity
APP_11700	COG3835	regulator
APP_11710	COG0277	FAD linked oxidase domain protein
APP_11720	COG0247	lactate metabolic process
APP_11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_11810	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APP_11840	COG1012	belongs to the aldehyde dehydrogenase family
APP_11890	COG0702	epimerase
APP_11970	COG0840	transmembrane signaling receptor activity
APP_12000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APP_12040	COG4988	ABC transporter
APP_12050	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APP_12060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APP_12070	COG1294	oxidase, subunit
APP_12080	COG1271	oxidase subunit
APP_12100	COG1131	(ABC) transporter
APP_12130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APP_12140	COG3383	formate dehydrogenase (NAD+) activity
APP_12150	COG2427	Protein of unknown function (DUF1641)
APP_12160	COG0326	Molecular chaperone. Has ATPase activity
APP_12170	COG1408	metallophosphoesterase
APP_12200	COG2610	gluconate transmembrane transporter activity
APP_12220	COG2084	Dehydrogenase
APP_12230	COG1802	Transcriptional regulator
APP_12240	COG2814	Major facilitator Superfamily
APP_12250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP_12260	COG1414	Transcriptional regulator
APP_12290	COG0824	Thioesterase
APP_12300	COG1021	2,3-dihydroxybenzoate-AMP ligase
APP_12320	COG2884	Cell division ATP-binding protein ftsE
APP_12430	COG0840	transmembrane signaling receptor activity
APP_12460	COG1476	TRANSCRIPTIONal
APP_12470	COG1414	Transcriptional regulator
APP_12480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APP_12500	COG0069	glutamate synthase activity
APP_12530	COG0004	ammonium transporteR
APP_12540	COG1960	acyl-CoA dehydrogenase activity
APP_12570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APP_12640	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP_12650	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP_12660	COG0183	Belongs to the thiolase family
APP_12670	COG1012	belongs to the aldehyde dehydrogenase family
APP_12680	COG1024	Enoyl-CoA hydratase
APP_12700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_12720	COG2151	metal-sulfur cluster biosynthetic enzyme
APP_12750	COG1024	Enoyl-CoA hydratase
APP_12760	COG1024	Enoyl-CoA hydratase
APP_12790	COG0318	PFAM AMP-dependent synthetase and ligase
APP_12800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APP_12820	COG1725	Transcriptional regulator
APP_12830	COG1131	(ABC) transporter
APP_12850	COG1595	DNA-templated transcription, initiation
APP_12870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP_12900	COG3344	reverse transcriptase
APP_12910	COG2322	membrane
APP_12920	COG0589	response to stress
APP_12930	COG0726	polysaccharide deacetylase
APP_12940	COG0492	ferredoxin-NADP+ reductase activity
APP_12950	COG3773	Cell wall hydrolase
APP_12990	COG1533	DNA photolyase activity
APP_13000	COG0492	ferredoxin-NADP+ reductase activity
APP_13040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_13050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_13060	COG1120	ATPase activity
APP_13070	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APP_13080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APP_13090	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
APP_13100	COG1492	cobalamin metabolic process
APP_13110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APP_13170	COG1253	flavin adenine dinucleotide binding
APP_13180	COG3344	reverse transcriptase
APP_13190	COG0840	transmembrane signaling receptor activity
APP_13230	COG3002	Belongs to the UPF0753 family
APP_13240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APP_13250	COG5609	conserved protein (DUF2294)
APP_13260	COG0527	aspartate kinase activity
APP_13270	COG0840	transmembrane signaling receptor activity
APP_13280	COG3344	reverse transcriptase
APP_13290	COG1846	Transcriptional regulator
APP_13300	COG5001	Diguanylate cyclase
APP_13300	COG3300	MHYT domain
APP_13310	COG1793	dna ligase
APP_13310	COG3285	dna ligase
APP_13320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APP_13320	COG0131	Imidazoleglycerol-phosphate dehydratase
APP_13330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
APP_13340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP_13360	COG0517	IMP dehydrogenase activity
APP_13360	COG4175	Glycine betaine
APP_13430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APP_13440	COG0768	penicillin binding
APP_13470	COG1032	radical SAM domain protein
APP_13480	COG2186	Transcriptional regulator
APP_13510	COG0247	lactate metabolic process
APP_13520	COG1139	Iron-sulfur cluster binding protein
APP_13530	COG1556	Lactate utilization protein
APP_13540	COG3594	Acyltransferase
APP_13550	COG5002	protein histidine kinase activity
APP_13560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APP_13570	COG3853	Toxic anion resistance protein (TelA)
APP_13580	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
APP_13590	COG0393	Putative heavy-metal-binding
APP_13640	COG3852	Histidine kinase
APP_13650	COG1846	Transcriptional regulator
APP_13660	COG1360	Flagellar Motor Protein
APP_13670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APP_13680	COG0542	response to heat
APP_13690	COG3949	Membrane
APP_13700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APP_13710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APP_13720	COG0720	synthase
APP_13740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APP_13750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APP_13760	COG4873	Protein conserved in bacteria
APP_13820	COG2244	polysaccharide biosynthetic process
APP_13830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_13850	COG2217	Heavy metal translocating P-type atpase
APP_13870	COG1525	nuclease
APP_13880	COG0205	6-phosphofructokinase activity
APP_13920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APP_13930	COG3711	transcriptional antiterminator
APP_13940	COG1263	PTS System
APP_13940	COG2190	(PTS) system
APP_13940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_13950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_13960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APP_13970	COG0840	transmembrane signaling receptor activity
APP_13980	COG1028	Short-chain dehydrogenase reductase Sdr
APP_13990	COG2084	Dehydrogenase
APP_14000	COG2340	Cysteine-rich secretory protein family
APP_14010	COG0768	penicillin binding
APP_14020	COG4191	Histidine kinase
APP_14030	COG0436	Aminotransferase
APP_14040	COG0598	Magnesium transport protein CorA
APP_14070	COG0835	chemotaxis
APP_14070	COG0784	Response regulator, receiver
APP_14090	COG0640	Transcriptional regulator
APP_14100	COG2814	Major facilitator Superfamily
APP_14110	COG1408	metallophosphoesterase
APP_14130	COG2200	EAL domain
APP_14150	COG1120	ATPase activity
APP_14160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_14170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_14180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_14200	COG0517	IMP dehydrogenase activity
APP_14210	COG0477	Major facilitator Superfamily
APP_14220	COG0583	DNA-binding transcription factor activity
APP_14230	COG2171	N-acyltransferase activity
APP_14240	COG1473	amidohydrolase
APP_14250	COG0668	transmembrane transport
APP_14260	COG0450	alkyl hydroperoxide reductase
APP_14270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_14290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APP_14300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APP_14310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APP_14320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APP_14340	COG1122	ATPase activity
APP_14410	COG0831	urea catabolic process
APP_14420	COG0832	Belongs to the urease beta subunit family
APP_14440	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APP_14500	COG1960	acyl-CoA dehydrogenase activity
APP_14510	COG1028	Short-chain dehydrogenase reductase Sdr
APP_14520	COG0318	PFAM AMP-dependent synthetase and ligase
APP_14530	COG2086	electron transfer activity
APP_14540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APP_14550	COG1960	acyl-CoA dehydrogenase activity
APP_14560	COG0183	Belongs to the thiolase family
APP_14570	COG1960	acyl-CoA dehydrogenase activity
APP_14590	COG2030	dehydratase
APP_14610	COG0183	Belongs to the thiolase family
APP_14620	COG0318	PFAM AMP-dependent synthetase and ligase
APP_14630	COG0559	Belongs to the binding-protein-dependent transport system permease family
APP_14690	COG1119	ATPase activity
APP_14700	COG0402	S-adenosylhomocysteine deaminase activity
APP_14760	COG0402	S-adenosylhomocysteine deaminase activity
APP_14770	COG0655	NAD(P)H dehydrogenase (quinone) activity
APP_14780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APP_14790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APP_14800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APP_14810	COG2080	2 iron, 2 sulfur cluster binding
APP_14820	COG2801	Transposase and inactivated derivatives
APP_14850	COG2351	hydroxyisourate hydrolase activity
APP_14870	COG2233	PERMEase
APP_14880	COG2508	Transcriptional regulator
APP_14890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APP_14900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APP_14910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APP_14920	COG2271	Major facilitator Superfamily
APP_14930	COG0673	inositol 2-dehydrogenase activity
APP_14940	COG1136	(ABC) transporter
APP_14940	COG0577	efflux transmembrane transporter activity
APP_14950	COG1136	(ABC) transporter
APP_14950	COG0577	efflux transmembrane transporter activity
APP_15010	COG1309	transcriptional regulator
APP_15040	COG2801	Transposase and inactivated derivatives
APP_15080	COG1349	DNA-binding transcription factor activity
APP_15090	COG1105	Belongs to the carbohydrate kinase PfkB family
APP_15100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_15100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP_15100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP_15130	COG2801	Transposase and inactivated derivatives
APP_15190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_15190	COG2207	Transcriptional regulator
APP_15200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_15210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_15220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_15230	COG2819	hydrolase of the alpha beta superfamily
APP_15240	COG0747	negative chemotaxis
APP_15250	COG0601	transmembrane transport
APP_15260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APP_15270	COG0444	Belongs to the ABC transporter superfamily
APP_15280	COG4608	Belongs to the ABC transporter superfamily
APP_15290	COG0534	Mate efflux family protein
APP_15300	COG1492	cobalamin metabolic process
APP_15310	COG2154	pterin-4-alpha-carbinolamine dehydratase
APP_15320	COG3835	regulator
APP_15330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APP_15340	COG2059	Chromate
APP_15350	COG2059	Chromate
APP_15360	COG1522	sequence-specific DNA binding
APP_15380	COG0405	Gamma-glutamyltransferase
APP_15420	COG3858	chitin binding
APP_15420	COG1388	LysM domain
APP_15430	COG1331	Highly conserved protein containing a thioredoxin domain
APP_15440	COG1331	Highly conserved protein containing a thioredoxin domain
APP_15480	COG0196	riboflavin kinase activity
APP_15530	COG0543	2 iron, 2 sulfur cluster binding
APP_15530	COG0633	Ferredoxin
APP_15550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APP_15580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP_15590	COG1136	(ABC) transporter
APP_15600	COG0577	efflux transmembrane transporter activity
APP_15610	COG0772	Belongs to the SEDS family
APP_15640	COG2309	aminopeptidase activity
APP_15650	COG1960	acyl-CoA dehydrogenase activity
APP_15660	COG2223	nitrite transmembrane transporter activity
APP_15690	COG0583	DNA-binding transcription factor activity
APP_15700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APP_15710	COG4637	Psort location Cytoplasmic, score
APP_15720	COG0569	domain protein
APP_15730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APP_15750	COG0561	phosphatase activity
APP_15760	COG0242	peptide deformylase activity
APP_15790	COG0022	dehydrogenase e1 component
APP_15800	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_15830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_15850	COG1982	Orn Lys Arg decarboxylase major
APP_15870	COG4493	Belongs to the UPF0637 family
APP_15880	COG0483	inositol monophosphate 1-phosphatase activity
APP_15930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APP_15940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APP_15950	COG4838	Belongs to the UPF0358 family
APP_15960	COG0772	Belongs to the SEDS family
APP_15970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APP_15980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APP_16010	COG0328	RNA-DNA hybrid ribonuclease activity
APP_16040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APP_16050	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
APP_16060	COG0386	Belongs to the glutathione peroxidase family
APP_16070	COG1413	lyase activity
APP_16100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APP_16110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APP_16120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APP_16130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APP_16150	COG1307	EDD domain protein, DegV family
APP_16160	COG1999	signal sequence binding
APP_16170	COG2755	lipolytic protein G-D-S-L family
APP_16180	COG4698	Protein conserved in bacteria
APP_16190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
APP_16190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APP_16210	COG2814	Major facilitator Superfamily
APP_16220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP_16220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP_16250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APP_16260	COG4479	Belongs to the UPF0346 family
APP_16280	COG0515	serine threonine protein kinase
APP_16290	COG4326	sporulation control protein
APP_16300	COG0671	phosphoesterase, PA-phosphatase related
APP_16330	COG1876	peptidase activity
APP_16340	COG0793	Belongs to the peptidase S41A family
APP_16340	COG3409	Peptidoglycan-binding domain 1 protein
APP_16370	COG2962	Rard protein
APP_16390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APP_16400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APP_16410	COG0791	NLP P60 protein
APP_16410	COG1388	LysM domain
APP_16430	COG0833	amino acid
APP_16440	COG0714	Associated with various cellular activities
APP_16450	COG4548	von Willebrand factor, type A
APP_16460	COG0567	Dehydrogenase, E1 component
APP_16470	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_16490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APP_16500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APP_16530	COG1012	belongs to the aldehyde dehydrogenase family
APP_16560	COG3546	catalase activity
APP_16590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APP_16690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP_16720	COG2323	membrane
APP_16730	COG0492	ferredoxin-NADP+ reductase activity
APP_16750	COG0129	dihydroxy-acid dehydratase activity
APP_16760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APP_16780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP_16800	COG1028	Short-chain dehydrogenase reductase Sdr
APP_16810	COG0534	Mate efflux family protein
APP_16840	COG0477	Major facilitator Superfamily
APP_16850	COG1309	transcriptional regulator
APP_16860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APP_16870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_16900	COG0840	transmembrane signaling receptor activity
APP_16930	COG1012	belongs to the aldehyde dehydrogenase family
APP_16940	COG1937	Protein conserved in bacteria
APP_16960	COG2608	mercury ion transmembrane transporter activity
APP_17000	COG2205	protein histidine kinase activity
APP_17040	COG3279	Response regulator of the LytR AlgR family
APP_17050	COG2199	diguanylate cyclase activity
APP_17050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APP_17090	COG1566	PFAM secretion protein HlyD family protein
APP_17100	COG2814	Major facilitator Superfamily
APP_17130	COG2258	MOSC domain
APP_17160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APP_17170	COG2079	MmgE PrpD family protein
APP_17180	COG0372	Belongs to the citrate synthase family
APP_17200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APP_17210	COG0667	Aldo Keto reductase
APP_17220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APP_17220	COG0723	plastoquinol--plastocyanin reductase activity
APP_17250	COG3275	phosphorelay sensor kinase activity
APP_17270	COG1966	Carbon starvation protein
APP_17280	COG1309	transcriptional regulator
APP_17290	COG0673	inositol 2-dehydrogenase activity
APP_17300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APP_17340	COG3226	Transcriptional regulator
APP_17360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APP_17380	COG1595	DNA-templated transcription, initiation
APP_17400	COG1846	Transcriptional regulator
APP_17410	COG1033	growth of symbiont in host cell
APP_17410	COG2409	Drug exporters of the RND superfamily
APP_17420	COG1388	LysM domain
APP_17420	COG3858	chitin binding
APP_17450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APP_17450	COG0551	DNA topoisomerase type I activity
APP_17470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APP_17520	COG2814	Major facilitator Superfamily
APP_17550	COG0561	phosphatase activity
APP_17560	COG1509	lysine 2,3-aminomutase activity
APP_17570	COG3239	Fatty acid desaturase
APP_17580	COG4585	Histidine kinase
APP_17590	COG2197	response regulator
APP_17610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP_17610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_17630	COG1937	Protein conserved in bacteria
APP_17640	COG0425	Belongs to the sulfur carrier protein TusA family
APP_17650	COG2210	Belongs to the sulfur carrier protein TusA family
APP_17670	COG0425	Belongs to the sulfur carrier protein TusA family
APP_17670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP_17680	COG0730	response to heat
APP_17690	COG0640	Transcriptional regulator
APP_17710	COG1012	belongs to the aldehyde dehydrogenase family
APP_17710	COG1454	alcohol dehydrogenase
APP_17810	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
APP_17820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APP_17830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APP_17840	COG0156	8-amino-7-oxononanoate synthase activity
APP_17860	COG2204	response regulator
APP_17900	COG1131	(ABC) transporter
APP_17930	COG0840	transmembrane signaling receptor activity
APP_17940	COG0640	Transcriptional regulator
APP_17950	COG5658	integral membrane protein
APP_17970	COG1131	(ABC) transporter
APP_18000	COG0385	Bile acid
APP_18040	COG0488	(ABC) transporter
APP_18050	COG0500	methyltransferase
APP_18060	COG0500	methyltransferase
APP_18080	COG1309	transcriptional regulator
APP_18090	COG1960	acyl-CoA dehydrogenase activity
APP_18100	COG0318	PFAM AMP-dependent synthetase and ligase
APP_18110	COG0439	Biotin carboxylase
APP_18120	COG0511	ligase activity, forming carbon-carbon bonds
APP_18130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APP_18140	COG1024	Enoyl-CoA hydratase
APP_18150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APP_18210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_18210	COG3711	transcriptional antiterminator
APP_18220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_18280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APP_18290	COG4149	molybdate abc transporter
APP_18300	COG1910	domain protein
APP_18320	COG0725	ABC transporter, periplasmic molybdate-binding protein
APP_18330	COG1028	Short-chain dehydrogenase reductase Sdr
APP_18340	COG3586	endonuclease activity
APP_18360	COG1960	acyl-CoA dehydrogenase activity
APP_18380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APP_18390	COG2011	ABC-type metal ion transport system permease component
APP_18400	COG0640	Transcriptional regulator
APP_18420	COG0798	PFAM Bile acid sodium symporter
APP_18430	COG0798	PFAM Bile acid sodium symporter
APP_18440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APP_18450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APP_18460	COG1279	arginine transmembrane transporter activity
APP_18470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APP_18480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APP_18490	COG1960	acyl-CoA dehydrogenase activity
APP_18550	COG0390	transport system, permease component
APP_18560	COG3842	ATPase activity
APP_18590	COG0314	molybdopterin synthase activity
APP_18600	COG1763	Mo-molybdopterin cofactor biosynthetic process
APP_18610	COG0303	'Molybdopterin
APP_18620	COG0746	molybdenum cofactor guanylyltransferase activity
APP_18700	COG2151	metal-sulfur cluster biosynthetic enzyme
APP_18720	COG0535	radical SAM domain protein
APP_18730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APP_18770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP_18780	COG0187	DNA topoisomerase II activity
APP_18790	COG1832	CoA-binding protein
APP_18800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APP_18810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APP_18810	COG1199	ATP-dependent helicase activity
APP_18830	COG0004	ammonium transporteR
APP_18850	COG4841	protein insertion into membrane
APP_18870	COG0824	Thioesterase
APP_18910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_18920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APP_18970	COG4846	Membrane protein involved in cytochrome C biogenesis
APP_18980	COG2201	protein-glutamate methylesterase activity
APP_18990	COG0785	Cytochrome C biogenesis protein
APP_19010	COG3763	UPF0154 protein
APP_19040	COG4224	UPF0291 protein
APP_19050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APP_19070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APP_19080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APP_19090	COG0204	Acyl-transferase
APP_19100	COG1611	Belongs to the LOG family
APP_19110	COG0667	Aldo Keto reductase
APP_19120	COG0400	carboxylic ester hydrolase activity
APP_19130	COG0346	lactoylglutathione lyase activity
APP_19150	COG1609	Transcriptional regulator
APP_19200	COG4585	Histidine kinase
APP_19210	COG2197	response regulator
APP_19230	COG0840	transmembrane signaling receptor activity
APP_19240	COG2200	EAL domain
APP_19300	COG3180	Ammonia monooxygenase
APP_19310	COG0583	DNA-binding transcription factor activity
APP_19360	COG1012	belongs to the aldehyde dehydrogenase family
APP_19370	COG0745	RESPONSE REGULATOR receiver
APP_19380	COG5002	protein histidine kinase activity
APP_19380	COG3850	Histidine kinase
APP_19400	COG0310	cobalt ion transport
APP_19430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APP_19440	COG1024	Enoyl-CoA hydratase
APP_19480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_19490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_19540	COG4372	Transposase
APP_19580	COG1132	(ABC) transporter
APP_19600	COG4372	Transposase
APP_19670	COG4372	Transposase
APP_19710	COG1070	Carbohydrate kinase
APP_19720	COG1609	Transcriptional regulator
APP_19740	COG2801	Transposase and inactivated derivatives
APP_19750	COG2801	Transposase and inactivated derivatives
APP_19770	COG2186	Transcriptional regulator
APP_19780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APP_19790	COG2721	sulfolactate sulfo-lyase activity
APP_19800	COG1312	Catalyzes the dehydration of D-mannonate
APP_19810	COG2271	Major facilitator Superfamily
APP_19840	COG3711	transcriptional antiterminator
APP_19890	COG0667	Aldo Keto reductase
APP_19910	COG0439	Biotin carboxylase
APP_19920	COG0511	ligase activity, forming carbon-carbon bonds
APP_19930	COG0511	ligase activity, forming carbon-carbon bonds
APP_19930	COG5016	pyruvate
APP_19950	COG1414	Transcriptional regulator
APP_19960	COG1414	Transcriptional regulator
APP_20020	COG4372	Transposase
APP_20070	COG1028	Short-chain dehydrogenase reductase Sdr
APP_20080	COG2801	Transposase and inactivated derivatives
APP_20200	COG0174	glutamine synthetase
APP_20210	COG0789	Transcriptional regulator
APP_20220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
APP_20230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APP_20250	COG0464	growth
APP_20260	COG1923	regulation of RNA biosynthetic process
APP_20270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APP_20290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APP_20300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APP_20310	COG3344	reverse transcriptase
APP_20330	COG4550	Control of competence regulator ComK, YlbF/YmcA
APP_20340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APP_20350	COG1013	pyruvate-flavodoxin oxidoreductase activity
APP_20360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APP_20360	COG0674	pyruvate-flavodoxin oxidoreductase activity
APP_20370	COG2359	stage V sporulation protein S
APP_20380	COG1692	metallophosphoesterase
APP_20390	COG1418	mRNA catabolic process
APP_20410	COG1058	Belongs to the CinA family
APP_20410	COG1546	Belongs to the CinA family
APP_20420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APP_20430	COG1426	Protein conserved in bacteria
APP_20460	COG0300	oxidoreductase activity
APP_20470	COG0612	Peptidase, M16
APP_20480	COG0612	Peptidase, M16
APP_20520	COG4980	gas vesicle protein
APP_20520	COG1674	ftsk spoiiie
APP_20540	COG0740	serine-type endopeptidase activity
APP_20550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APP_20570	COG0527	aspartate kinase activity
APP_20580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APP_20590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APP_20600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APP_20610	COG1873	PFAM PRC-barrel domain
APP_20620	COG0612	Peptidase, M16
APP_20630	COG0726	polysaccharide deacetylase
APP_20640	COG1185	polyribonucleotide nucleotidyltransferase activity
APP_20650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APP_20660	COG0196	riboflavin kinase activity
APP_20670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APP_20680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APP_20690	COG1550	Protein conserved in bacteria
APP_20700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APP_20710	COG1358	cellular component organization or biogenesis
APP_20720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
APP_20730	COG0195	Participates in both transcription termination and antitermination
APP_20740	COG0779	Required for maturation of 30S ribosomal subunits
APP_20750	COG2176	DNA-directed DNA polymerase activity
APP_20760	COG0442	prolyl-tRNA aminoacylation
APP_20770	COG0750	zinc metalloprotease
APP_20780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APP_20790	COG4589	Belongs to the CDS family
APP_20800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APP_20810	COG0233	cytoplasmic translational termination
APP_20820	COG0528	UMP kinase activity
APP_20830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APP_20840	COG0052	Belongs to the universal ribosomal protein uS2 family
APP_20860	COG1191	sigma factor activity
APP_20870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APP_20880	COG1776	CheC inhibitor of MCP methylation
APP_20890	COG0835	chemotaxis
APP_20900	COG2198	Histidine kinase
APP_20900	COG0643	Histidine kinase
APP_20910	COG2201	protein-glutamate methylesterase activity
APP_20920	COG0455	bacterial-type flagellum organization
APP_20930	COG1419	protein localization to endoplasmic reticulum
APP_20940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APP_20950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APP_20960	COG1684	flagellar biosynthetic protein fliR
APP_20970	COG1987	bacterial-type flagellum assembly
APP_20980	COG1338	Plays a role in the flagellum-specific transport system
APP_20990	COG3190	flagellar
APP_21000	COG2201	protein-glutamate methylesterase activity
APP_21010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APP_21010	COG1776	CheC inhibitor of MCP methylation
APP_21020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APP_21030	COG1580	Controls the rotational direction of flagella during chemotaxis
APP_21040	COG1582	Flagellar protein (FlbD)
APP_21050	COG4786	Flagellar basal body rod
APP_21060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APP_21070	COG3144	bacterial-type flagellum assembly
APP_21090	COG2882	bacterial-type flagellum organization
APP_21100	COG1157	protein secretion by the type III secretion system
APP_21110	COG1317	bacterial-type flagellum organization
APP_21120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APP_21130	COG1766	The M ring may be actively involved in energy transduction
APP_21140	COG1677	Flagellar hook-basal body complex protein FliE
APP_21150	COG1558	bacterial-type flagellum-dependent cell motility
APP_21160	COG1815	bacterial-type flagellum-dependent cell motility
APP_21170	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APP_21180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APP_21190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APP_21200	COG4974	Belongs to the 'phage' integrase family
APP_21210	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APP_21220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APP_21230	COG0758	DNA mediated transformation
APP_21240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APP_21250	COG0045	succinate-CoA ligase (ADP-forming) activity
APP_21260	COG2257	FlhB HrpN YscU SpaS Family
APP_21280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APP_21310	COG0335	large ribosomal subunit rRNA binding
APP_21330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APP_21360	COG1837	Belongs to the UPF0109 family
APP_21370	COG0228	four-way junction DNA binding
APP_21380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APP_21390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APP_21400	COG0552	protein localization to endoplasmic reticulum
APP_21410	COG1196	nuclear chromosome segregation
APP_21420	COG0571	ribonuclease III activity
APP_21430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APP_21440	COG1028	Short-chain dehydrogenase reductase Sdr
APP_21450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APP_21460	COG0416	fatty acid biosynthetic process
APP_21470	COG1349	DNA-binding transcription factor activity
APP_21480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APP_21490	COG1461	Dihydroxyacetone kinase
APP_21500	COG1302	Protein conserved in bacteria
APP_21510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APP_21520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APP_21540	COG0515	serine threonine protein kinase
APP_21540	COG2815	serine threonine protein kinase
APP_21550	COG0631	protein serine/threonine phosphatase activity
APP_21570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APP_21570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APP_21580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APP_21590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APP_21600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APP_21610	COG1758	RNA polymerase activity
APP_21620	COG0194	GDP metabolic process
APP_21630	COG2052	Domain of unknown function (DUF370)
APP_21640	COG1561	YicC-like family, N-terminal region
APP_21650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APP_21670	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
APP_21680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APP_21700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APP_21710	COG0529	Catalyzes the synthesis of activated sulfate
APP_21720	COG2046	Belongs to the sulfate adenylyltransferase family
APP_21730	COG0175	sulfate reduction
APP_21740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APP_21750	COG0284	orotidine-5'-phosphate decarboxylase activity
APP_21760	COG0167	dihydroorotate dehydrogenase activity
APP_21770	COG0543	2 iron, 2 sulfur cluster binding
APP_21780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APP_21810	COG0540	Belongs to the ATCase OTCase family
APP_21830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APP_21840	COG0564	pseudouridine synthase activity
APP_21850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APP_21860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APP_21870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APP_21880	COG3599	regulation of cell shape
APP_21900	COG2302	S4 RNA-binding domain
APP_21910	COG0762	integral membrane protein
APP_21920	COG1799	cell septum assembly
APP_21930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APP_21950	COG1873	PFAM PRC-barrel domain
APP_21970	COG1191	sigma factor activity
APP_21980	COG1191	sigma factor activity
APP_22000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APP_22010	COG0849	cell division
APP_22020	COG3856	small basic protein
APP_22030	COG3879	Bacterial protein of unknown function (DUF881)
APP_22040	COG3879	Bacterial protein of unknown function (DUF881)
APP_22050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APP_22060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APP_22070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APP_22080	COG0772	Belongs to the SEDS family
APP_22090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APP_22100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APP_22110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APP_22120	COG0768	penicillin binding
APP_22140	COG4839	cell division protein FtsL
APP_22150	COG0275	rRNA processing
APP_22160	COG2001	Belongs to the MraZ family
APP_22170	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
APP_22190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APP_22200	COG0454	-acetyltransferase
APP_22220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APP_22230	COG1399	metal-binding, possibly nucleic acid-binding protein
APP_22240	COG1323	Belongs to the UPF0348 family
APP_22250	COG3480	Lon protease (S16) C-terminal proteolytic domain
APP_22260	COG1752	Esterase of the alpha-beta hydrolase superfamily
APP_22270	COG3314	Sporulation integral membrane protein YlbJ
APP_22280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APP_22290	COG0742	ribosomal rna small subunit methyltransferase
APP_22310	COG4471	UPF0298 protein
APP_22320	COG3679	Belongs to the UPF0342 family
APP_22360	COG2340	Cysteine-rich secretory protein family
APP_22370	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
APP_22390	COG3336	cytochrome c oxidase
APP_22400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APP_22410	COG1845	cytochrome c oxidase, subunit III
APP_22420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APP_22430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APP_22430	COG2010	Cytochrome c
APP_22440	COG0109	protoheme IX farnesyltransferase activity
APP_22450	COG1612	heme a metabolic process
APP_22460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
APP_22470	COG1199	ATP-dependent helicase activity
APP_22490	COG0116	Belongs to the methyltransferase superfamily
APP_22520	COG3359	exonuclease
APP_22530	COG1205	dead DEAH box helicase
APP_22530	COG1111	helicase
APP_22610	COG3331	DNA recombination
APP_22620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP_22620	COG4499	WXG100 protein secretion system (Wss), protein YukC
APP_22640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APP_22650	COG3935	DnaD domain protein
APP_22660	COG0017	Asparaginyl-tRNA synthetase
APP_22670	COG0436	Aminotransferase
APP_22710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APP_22720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APP_22750	COG0617	tRNA 3'-terminal CCA addition
APP_22760	COG0438	transferase activity, transferring glycosyl groups
APP_22770	COG1803	Methylglyoxal synthase
APP_22780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APP_22790	COG1694	Mazg nucleotide pyrophosphohydrolase
APP_22800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APP_22820	COG4347	Protein of unknown function (DUF1405)
APP_22840	COG1115	amino acid carrier protein
APP_22850	COG2010	Cytochrome c
APP_22850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APP_22860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APP_22890	COG5582	Belongs to the UPF0302 family
APP_22900	COG0457	Tetratricopeptide repeat
APP_22930	COG0287	Prephenate dehydrogenase
APP_22950	COG0159	tryptophan synthase activity
APP_22970	COG0135	phosphoribosylanthranilate isomerase activity
APP_22980	COG0134	indole-3-glycerol-phosphate synthase activity
APP_22990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APP_23010	COG4401	Chorismate mutase type I
APP_23020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APP_23040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APP_23050	COG0105	UTP biosynthetic process
APP_23060	COG0142	geranyltranstransferase activity
APP_23070	COG2226	methyltransferase
APP_23080	COG0142	geranyltranstransferase activity
APP_23100	COG0302	gtp cyclohydrolase
APP_23110	COG0776	regulation of translation
APP_23160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APP_23170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APP_23180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APP_23220	COG1160	GTP binding
APP_23270	COG0539	negative regulation of cytoplasmic translation
APP_23280	COG0204	Acyl-transferase
APP_23290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APP_23310	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
APP_23320	COG2959	enzyme of heme biosynthesis
APP_23330	COG3773	Cell wall hydrolase
APP_23330	COG3409	Peptidoglycan-binding domain 1 protein
APP_23340	COG2339	peptidase activity
APP_23360	COG0492	ferredoxin-NADP+ reductase activity
APP_23370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APP_23380	COG4862	establishment of competence for transformation
APP_23400	COG1388	LysM domain
APP_23410	COG1266	CAAX protease self-immunity
APP_23420	COG0514	ATP-dependent DNA helicase (RecQ)
APP_23430	COG4955	Helix-turn-helix domain
APP_23450	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APP_23470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APP_23500	COG1595	DNA-templated transcription, initiation
APP_23510	COG2096	Adenosyltransferase
APP_23520	COG5002	protein histidine kinase activity
APP_23530	COG0745	RESPONSE REGULATOR receiver
APP_23540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP_23550	COG1333	cytochrome c biogenesis protein
APP_23560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP_23570	COG1187	pseudouridine synthase activity
APP_23580	COG0700	Nucleoside recognition
APP_23590	COG2715	membrane protein required for spore maturation
APP_23600	COG1686	Belongs to the peptidase S11 family
APP_23610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APP_23620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APP_23630	COG1547	Domain of unknown function (DUF309)
APP_23640	COG0456	acetyltransferase
APP_23650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APP_23660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APP_23660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APP_23670	COG0307	riboflavin synthase, alpha
APP_23680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APP_23680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APP_23690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APP_23700	COG4086	secreted protein
APP_23710	COG0019	diaminopimelate decarboxylase activity
APP_23720	COG0697	spore germination
APP_23730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP_23780	COG1366	Belongs to the anti-sigma-factor antagonist family
APP_23790	COG1686	Belongs to the peptidase S11 family
APP_23830	COG4974	Belongs to the 'phage' integrase family
APP_23850	COG0735	belongs to the Fur family
APP_23860	COG1300	Membrane
APP_23870	COG1379	DNA repair
APP_23880	COG0494	nUDIX hydrolase
APP_23900	COG0667	Aldo Keto reductase
APP_23920	COG0109	protoheme IX farnesyltransferase activity
APP_23950	COG0316	Belongs to the HesB IscA family
APP_23960	COG2226	methyltransferase
APP_23970	COG5646	InterPro IPR014922
APP_23980	COG5646	InterPro IPR014922
APP_24030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APP_24050	COG0300	oxidoreductase activity
APP_24060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_24070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APP_24080	COG1902	pentaerythritol trinitrate reductase activity
APP_24110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APP_24120	COG1254	Belongs to the acylphosphatase family
APP_24130	COG4214	carbohydrate transport
APP_24140	COG1129	ABC transporter
APP_24150	COG4213	ABC transporter substrate-binding protein
APP_24160	COG3279	Response regulator of the LytR AlgR family
APP_24170	COG2972	Histidine kinase
APP_24190	COG1657	PFAM Prenyltransferase squalene oxidase
APP_24220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APP_24230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APP_24240	COG0493	'glutamate synthase
APP_24250	COG0070	glutamate synthase
APP_24250	COG0069	glutamate synthase activity
APP_24250	COG0067	glutamate synthase
APP_24260	COG0583	DNA-binding transcription factor activity
APP_24270	COG2195	Cleaves the N-terminal amino acid of tripeptides
APP_24280	COG4129	membrane
APP_24300	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_24310	COG0022	dehydrogenase e1 component
APP_24320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APP_24330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP_24350	COG0745	RESPONSE REGULATOR receiver
APP_24360	COG0750	zinc metalloprotease
APP_24370	COG0497	DNA recombination
APP_24380	COG1438	arginine binding
APP_24390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APP_24400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APP_24430	COG0142	geranyltranstransferase activity
APP_24440	COG1722	exodeoxyribonuclease VII activity
APP_24450	COG1570	exodeoxyribonuclease VII activity
APP_24460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APP_24480	COG1302	Protein conserved in bacteria
APP_24490	COG0439	Biotin carboxylase
APP_24500	COG0511	ligase activity, forming carbon-carbon bonds
APP_24580	COG3854	ATPases associated with a variety of cellular activities
APP_24600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APP_24610	COG0006	proline dipeptidase activity
APP_24620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APP_24640	COG3872	metal-dependent enzyme
APP_24660	COG1752	Esterase of the alpha-beta hydrolase superfamily
APP_24670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP_24680	COG0095	Lipoate-protein ligase
APP_24690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP_24710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APP_24720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APP_24730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APP_24800	COG4537	Required for transformation and DNA binding
APP_24810	COG1459	type II secretion system
APP_24820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APP_24840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_24880	COG1368	sulfuric ester hydrolase activity
APP_24890	COG1940	carbohydrate kinase activity
APP_24900	COG4483	Protein conserved in bacteria
APP_24910	COG0457	Tetratricopeptide repeat
APP_24910	COG0705	Rhomboid family
APP_24930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APP_24940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APP_24960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APP_24970	COG0704	Plays a role in the regulation of phosphate uptake
APP_24980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APP_24990	COG0581	inorganic phosphate transmembrane transporter activity
APP_25000	COG0573	inorganic phosphate transmembrane transporter activity
APP_25010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APP_25020	COG0477	Major facilitator Superfamily
APP_25050	COG2839	Protein conserved in bacteria
APP_25060	COG1283	sodium-dependent phosphate transmembrane transporter activity
APP_25080	COG5521	maltodextrose utilization protein MalA
APP_25090	COG0840	transmembrane signaling receptor activity
APP_25100	COG2814	Major facilitator Superfamily
APP_25110	COG1388	LysM domain
APP_25120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APP_25130	COG4709	membrane
APP_25150	COG0735	belongs to the Fur family
APP_25160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP_25170	COG1121	(ABC) transporter
APP_25180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APP_25200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APP_25210	COG0513	Belongs to the DEAD box helicase family
APP_25230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APP_25240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APP_25250	COG2384	SAM-dependent methyltransferase
APP_25260	COG2010	Cytochrome c
APP_25270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APP_25280	COG0358	DNA primase activity
APP_25300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APP_25310	COG0517	IMP dehydrogenase activity
APP_25320	COG0751	glycine-tRNA ligase activity
APP_25330	COG0752	glycyl-tRNA synthetase alpha subunit
APP_25340	COG1381	Involved in DNA repair and RecF pathway recombination
APP_25360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APP_25370	COG0295	cytidine deaminase activity
APP_25380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APP_25400	COG1480	7TM receptor with intracellular HD hydrolase
APP_25410	COG1702	phosphate starvation-inducible protein PhoH
APP_25450	COG4864	UPF0365 protein
APP_25460	COG1030	water channel activity
APP_25470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APP_25480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APP_25490	COG0726	polysaccharide deacetylase
APP_25500	COG1610	YqeY-like protein
APP_25510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APP_25520	COG1283	sodium-dependent phosphate transmembrane transporter activity
APP_25530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APP_25540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APP_25550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APP_25560	COG2264	protein methyltransferase activity
APP_25570	COG0484	heat shock protein binding
APP_25580	COG0443	Heat shock 70 kDa protein
APP_25590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APP_25600	COG1420	regulation of RNA biosynthetic process
APP_25610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP_25620	COG0481	GTPase activity
APP_25640	COG0860	N-Acetylmuramoyl-L-alanine amidase
APP_25660	COG0268	Binds directly to 16S ribosomal RNA
APP_25670	COG1466	dna polymerase III delta subunit
APP_25690	COG2333	competence protein COMEC
APP_25690	COG0658	competence protein
APP_25700	COG2131	deaminase
APP_25710	COG1596	polysaccharide export
APP_25710	COG1555	photosystem II stabilization
APP_25720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APP_25730	COG2226	methyltransferase
APP_25740	COG0799	negative regulation of ribosome biogenesis
APP_25750	COG1713	HD superfamily hydrolase involved in NAD metabolism
APP_25760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APP_25770	COG1534	Rna-binding protein
APP_25780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APP_25790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APP_25800	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APP_25840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APP_25860	COG0768	penicillin binding
APP_25870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APP_25900	COG4122	O-methyltransferase activity
APP_25910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APP_25920	COG3906	Belongs to the UPF0473 family
APP_25930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APP_25950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APP_25960	COG0628	permease
APP_25980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APP_26000	COG0482	sulfurtransferase activity
APP_26010	COG1104	cysteine desulfurase activity
APP_26020	COG1959	2 iron, 2 sulfur cluster binding
APP_26030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APP_26040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APP_26050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APP_26060	COG0124	histidyl-tRNA synthetase
APP_26080	COG4991	sh3 domain protein
APP_26080	COG3103	Sh3 type 3 domain protein
APP_26080	COG0860	N-Acetylmuramoyl-L-alanine amidase
APP_26090	COG1490	D-aminoacyl-tRNA deacylase activity
APP_26100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APP_26110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APP_26120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APP_26120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APP_26160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP_26160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP_26180	COG2244	polysaccharide biosynthetic process
APP_26200	COG1862	Preprotein translocase
APP_26210	COG0343	queuine tRNA-ribosyltransferase activity
APP_26220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APP_26250	COG0632	four-way junction helicase activity
APP_26270	COG0217	transcriptional regulatory protein
APP_26290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APP_26300	COG1388	LysM domain
APP_26310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APP_26320	COG0157	Belongs to the NadC ModD family
APP_26330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APP_26340	COG1104	cysteine desulfurase activity
APP_26350	COG1827	regulation of RNA biosynthetic process
APP_26360	COG0077	Prephenate dehydratase
APP_26370	COG4492	Belongs to the UPF0735 family
APP_26380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APP_26390	COG3290	protein histidine kinase activity
APP_26400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APP_26410	COG2868	ribosomal protein
APP_26420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APP_26430	COG1530	ribonuclease E activity
APP_26440	COG1994	Peptidase M50
APP_26450	COG0739	heme binding
APP_26460	COG1914	H( )-stimulated, divalent metal cation uptake system
APP_26470	COG0778	Nitroreductase
APP_26480	COG2894	cell division
APP_26490	COG0850	regulation of cytokinetic process
APP_26500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APP_26520	COG1077	Cell shape determining protein MreB Mrl
APP_26530	COG2003	Belongs to the UPF0758 family
APP_26560	COG0285	dihydrofolate synthase activity
APP_26600	COG1388	LysM domain
APP_26610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APP_26620	COG0113	porphobilinogen synthase activity
APP_26640	COG0181	hydroxymethylbilane synthase activity
APP_26650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP_26680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APP_26690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APP_26700	COG1067	ATP-dependent peptidase activity
APP_26700	COG0470	DNA polymerase III
APP_26710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APP_26720	COG0544	peptidyl-prolyl cis-trans isomerase activity
APP_26730	COG0457	Tetratricopeptide repeat
APP_26730	COG1477	protein flavinylation
APP_26740	COG0066	3-isopropylmalate dehydratase activity
APP_26750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APP_26760	COG0473	3-isopropylmalate dehydrogenase activity
APP_26770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APP_26780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APP_26790	COG0440	acetolactate synthase activity
APP_26800	COG0028	Belongs to the TPP enzyme family
APP_26840	COG0205	6-phosphofructokinase activity
APP_26870	COG1028	Short-chain dehydrogenase reductase Sdr
APP_26880	COG3958	Transketolase
APP_26890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APP_26910	COG2186	Transcriptional regulator
APP_26920	COG1522	sequence-specific DNA binding
APP_26940	COG3723	Recombinational DNA repair protein, rece pathway
APP_26950	COG3723	Recombinational DNA repair protein, rece pathway
APP_26990	COG4974	Belongs to the 'phage' integrase family
APP_27000	COG0622	Phosphoesterase
APP_27010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APP_27020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APP_27030	COG5401	PFAM Sporulation and spore germination
APP_27040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APP_27050	COG1846	Transcriptional regulator
APP_27060	COG2197	response regulator
APP_27070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APP_27080	COG1053	succinate dehydrogenase
APP_27090	COG2009	succinate dehydrogenase
APP_27100	COG1719	4-vinyl reductase, 4VR
APP_27110	COG0322	excinuclease ABC activity
APP_27120	COG3118	belongs to the thioredoxin family
APP_27130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APP_27140	COG2086	electron transfer activity
APP_27150	COG1309	transcriptional regulator
APP_27160	COG0318	PFAM AMP-dependent synthetase and ligase
APP_27170	COG3766	membrane
APP_27180	COG1193	negative regulation of DNA recombination
APP_27190	COG1796	DNA polymerase
APP_27190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
APP_27200	COG1286	toxin biosynthetic process
APP_27210	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APP_27230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APP_27230	COG0072	phenylalanine-tRNA ligase activity
APP_27240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APP_27260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP_27280	COG1363	Peptidase, m42
APP_27310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APP_27320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APP_27330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APP_27350	COG5146	pantothenate kinase activity
APP_27360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APP_27380	COG1484	DNA-dependent DNA replication
APP_27390	COG3611	Membrane attachment protein
APP_27400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APP_27410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APP_27420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APP_27440	COG1971	Probably functions as a manganese efflux pump
APP_27450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APP_27460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP_27460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP_27470	COG0330	HflC and HflK could
APP_27480	COG0330	HflC and HflK could
APP_27490	COG5002	protein histidine kinase activity
APP_27500	COG0745	RESPONSE REGULATOR receiver
APP_27520	COG0538	isocitrate dehydrogenase activity
APP_27530	COG0372	Belongs to the citrate synthase family
APP_27540	COG3030	protein affecting phage T7 exclusion by the F plasmid
APP_27560	COG0205	6-phosphofructokinase activity
APP_27570	COG0825	malonyl-CoA metabolic process
APP_27580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APP_27590	COG0281	malic enzyme
APP_27600	COG0587	DNA-directed DNA polymerase activity
APP_27630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APP_27650	COG4109	DRTGG domain
APP_27660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
APP_27670	COG1028	Short-chain dehydrogenase reductase Sdr
APP_27690	COG0165	Argininosuccinate lyase
APP_27700	COG0137	argininosuccinate synthase activity
APP_27740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APP_27760	COG0827	DNA restriction-modification system
APP_27770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APP_27780	COG3874	Sporulation protein YtfJ
APP_27800	COG1714	RDD family
APP_27810	COG0616	signal peptide processing
APP_27820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APP_27840	COG0301	tRNA thio-modification
APP_27850	COG1104	cysteine desulfurase activity
APP_27860	COG3842	ATPase activity
APP_27870	COG0656	L-ascorbic acid biosynthetic process
APP_27880	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APP_27890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
APP_27900	COG1309	transcriptional regulator
APP_27910	COG1956	GAF domain-containing protein
APP_27920	COG2203	Gaf domain
APP_27920	COG2199	diguanylate cyclase activity
APP_27930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APP_28010	COG4977	sequence-specific DNA binding
APP_28020	COG0179	Fumarylacetoacetate (FAA) hydrolase
APP_28030	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APP_28040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APP_28050	COG0471	metal ion transport
APP_28120	COG3328	transposase activity
APP_28170	COG0456	acetyltransferase
APP_28180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APP_28190	COG0454	-acetyltransferase
APP_28200	COG0517	IMP dehydrogenase activity
APP_28210	COG0123	including yeast histone deacetylase and acetoin utilization protein
APP_28220	COG1609	Transcriptional regulator
APP_28230	COG1605	Chorismate mutase
APP_28230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APP_28250	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
APP_28260	COG2309	aminopeptidase activity
APP_28270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APP_28280	COG1674	ftsk spoiiie
APP_28290	COG0501	Belongs to the peptidase M48B family
APP_28310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APP_28320	COG1396	sequence-specific DNA binding
APP_28330	COG1116	anion transmembrane transporter activity
APP_28330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP_28340	COG4120	Belongs to the binding-protein-dependent transport system permease family
APP_28360	COG1234	tRNA 3'-trailer cleavage
APP_28370	COG1609	Transcriptional regulator
APP_28400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APP_28410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP_28420	COG2329	Antibiotic biosynthesis monooxygenase
APP_28430	COG1131	(ABC) transporter
APP_28440	COG4473	ABC transporter
APP_28450	COG0537	adenosine 5'-monophosphoramidase activity
APP_28460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APP_28490	COG4980	gas vesicle protein
APP_28500	COG1846	Transcriptional regulator
APP_28530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP_28550	COG3481	metal-dependent phosphohydrolase, HD sub domain
APP_28560	COG4717	serine-type aminopeptidase activity
APP_28570	COG0420	3'-5' exonuclease activity
APP_28600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP_28610	COG0561	phosphatase activity
APP_28640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APP_28650	COG3679	Belongs to the UPF0342 family
APP_28690	COG0697	spore germination
APP_28700	COG4399	Belongs to the UPF0754 family
APP_28720	COG0189	ligase activity
APP_28730	COG0189	ligase activity
APP_28740	COG0189	ligase activity
APP_28790	COG0583	DNA-binding transcription factor activity
APP_28850	COG0411	ABC transporter
APP_28870	COG0840	transmembrane signaling receptor activity
APP_28890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP_28900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP_28920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APP_28940	COG0628	permease
APP_28970	COG0861	Integral membrane protein TerC family
APP_28980	COG2719	SpoVR family
APP_29000	COG1959	2 iron, 2 sulfur cluster binding
APP_29020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APP_29030	COG0517	IMP dehydrogenase activity
APP_29060	COG0656	L-ascorbic acid biosynthetic process
APP_29070	COG2249	NAD(P)H dehydrogenase (quinone) activity
APP_29090	COG0586	Pfam SNARE associated Golgi protein
APP_29100	COG0183	Belongs to the thiolase family
APP_29110	COG0318	PFAM AMP-dependent synthetase and ligase
APP_29120	COG1268	BioY protein
APP_29140	COG2718	Belongs to the UPF0229 family
APP_29150	COG2766	serine protein kinase
APP_29200	COG3382	B3 4 domain protein
APP_29250	COG2226	methyltransferase
APP_29260	COG0431	NADPH-dependent FMN reductase
APP_29280	COG2814	Major facilitator Superfamily
APP_29290	COG1063	alcohol dehydrogenase
APP_29300	COG1069	ribulokinase activity
APP_29330	COG1012	belongs to the aldehyde dehydrogenase family
APP_29350	COG5002	protein histidine kinase activity
APP_29370	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_29380	COG0022	dehydrogenase e1 component
APP_29390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APP_29410	COG3284	Transcriptional regulator
APP_29420	COG2822	iron ion transport
APP_29430	COG2837	iron assimilation
APP_29460	COG0702	epimerase
APP_29470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP_29480	COG0482	sulfurtransferase activity
APP_29490	COG1959	2 iron, 2 sulfur cluster binding
APP_29500	COG1280	lysine exporter protein (LysE YggA)
APP_29550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APP_29560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP_29570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_29600	COG2376	Dihydroxyacetone kinase
APP_29610	COG3829	transcription factor binding
APP_29610	COG3290	protein histidine kinase activity
APP_29620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
APP_29630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APP_30000	COG3677	Transposase
APP_30060	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APP_30090	COG0305	Participates in initiation and elongation during chromosome replication
APP_30110	COG3723	Recombinational DNA repair protein, rece pathway
APP_30120	COG5377	YqaJ viral recombinase family
APP_30170	COG1396	sequence-specific DNA binding
APP_30190	COG4974	Belongs to the 'phage' integrase family
APP_30210	COG0735	belongs to the Fur family
APP_30220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP_30260	COG4555	ABC transporter
APP_30270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APP_30280	COG4129	membrane
APP_30300	COG1132	(ABC) transporter
APP_30310	COG3557	Belongs to the UPF0374 family
APP_30330	COG1968	undecaprenyl-diphosphatase activity
APP_30350	COG1028	Short-chain dehydrogenase reductase Sdr
APP_30370	COG1194	a g-specific adenine glycosylase
APP_30380	COG1988	membrane-bound metal-dependent
APP_30420	COG2137	regulation of response to DNA damage stimulus
APP_30490	COG0861	Integral membrane protein TerC family
APP_30500	COG0583	DNA-binding transcription factor activity
APP_30510	COG0028	Belongs to the TPP enzyme family
APP_30520	COG2271	Major facilitator Superfamily
APP_30530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP_30550	COG2066	Belongs to the glutaminase family
APP_30560	COG2814	Major facilitator Superfamily
APP_30570	COG0583	DNA-binding transcription factor activity
APP_30600	COG0156	8-amino-7-oxononanoate synthase activity
APP_30610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APP_30620	COG0385	Bile acid
APP_30630	COG2329	Antibiotic biosynthesis monooxygenase
APP_30640	COG0626	cystathionine gamma-synthase activity
APP_30680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APP_30720	COG0789	Transcriptional regulator
APP_30750	COG2814	Major facilitator Superfamily
APP_30760	COG0501	Belongs to the peptidase M48B family
APP_30770	COG1742	UPF0060 membrane protein
APP_30800	COG1597	lipid kinase activity
APP_30840	COG1063	alcohol dehydrogenase
APP_30850	COG0235	Class ii aldolase
APP_30860	COG1063	alcohol dehydrogenase
APP_30890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APP_30920	COG2801	Transposase and inactivated derivatives
APP_30980	COG1116	anion transmembrane transporter activity
APP_31010	COG1694	Mazg nucleotide pyrophosphohydrolase
APP_31020	COG1309	transcriptional regulator
APP_31040	COG1028	Short-chain dehydrogenase reductase Sdr
APP_31080	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APP_31090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APP_31100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APP_31120	COG2721	sulfolactate sulfo-lyase activity
APP_31160	COG2197	response regulator
APP_31220	COG1131	(ABC) transporter
APP_31250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APP_31340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APP_31350	COG1535	isochorismatase
APP_31350	COG3433	isochorismatase activity
APP_31360	COG1021	2,3-dihydroxybenzoate-AMP ligase
APP_31370	COG1169	isochorismate synthase
APP_31380	COG1028	Short-chain dehydrogenase reductase Sdr
APP_31450	COG4372	Transposase
APP_31490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP_31490	COG1263	PTS System
APP_31500	COG1486	melibiose metabolic process
APP_31510	COG1737	Transcriptional regulator
APP_31520	COG2190	(PTS) system
APP_31600	COG4499	WXG100 protein secretion system (Wss), protein YukC
APP_31710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APP_31720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APP_31730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APP_31760	COG0436	Aminotransferase
APP_31770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APP_31780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APP_31800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APP_31810	COG0235	Class ii aldolase
APP_31820	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
APP_31830	COG1850	ribulose-bisphosphate carboxylase activity
APP_31910	COG0535	radical SAM domain protein
APP_31930	COG0387	Pfam Sodium calcium exchanger
APP_31940	COG1309	transcriptional regulator
APP_31950	COG1511	domain protein
APP_32000	COG1295	ribonuclease BN
APP_32010	COG4980	gas vesicle protein
APP_32020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APP_32030	COG4840	Belongs to the UPF0435 family
APP_32070	COG2311	Membrane
APP_32090	COG4948	Mandelate Racemase Muconate Lactonizing
APP_32100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APP_32110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APP_32150	COG1960	acyl-CoA dehydrogenase activity
APP_32170	COG1733	regulation of RNA biosynthetic process
APP_32200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP_32210	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
APP_32220	COG1653	transport
APP_32230	COG1175	transmembrane transport
APP_32240	COG0395	ABC-type sugar transport system, permease component
APP_32250	COG3842	ATPase activity
APP_32280	COG1587	Uroporphyrinogen-III synthase
APP_32310	COG4607	ABC-type enterochelin transport system periplasmic component
APP_32320	COG4604	ABC transporter, ATP-binding protein
APP_32330	COG4605	iron ion homeostasis
APP_32340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP_32350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APP_32360	COG0561	phosphatase activity
APP_32370	COG1132	(ABC) transporter
APP_32380	COG1132	(ABC) transporter
APP_32390	COG0753	catalase activity
APP_32400	COG2814	Major facilitator Superfamily
APP_32420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APP_32430	COG1177	transmembrane transport
APP_32440	COG1176	ABC-type spermidine putrescine transport system, permease component I
APP_32450	COG3842	ATPase activity
APP_32480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APP_32500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APP_32510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APP_32520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APP_32560	COG1012	belongs to the aldehyde dehydrogenase family
APP_32600	COG3711	transcriptional antiterminator
APP_32610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_32620	COG0246	Mannitol dehydrogenase
APP_32650	COG2966	Psort location CytoplasmicMembrane, score
APP_32660	COG1309	transcriptional regulator
APP_32670	COG2814	Major facilitator Superfamily
APP_32680	COG0183	Belongs to the thiolase family
APP_32690	COG1473	amidohydrolase
APP_32700	COG0475	glutathione-regulated potassium exporter activity
APP_32710	COG0490	domain, Protein
APP_32720	COG0582	viral genome integration into host DNA
APP_32740	COG0840	transmembrane signaling receptor activity
APP_32750	COG0531	amino acid
APP_32780	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APP_32790	COG1518	maintenance of DNA repeat elements
APP_32860	COG1309	transcriptional regulator
APP_32890	COG1126	abc transporter atp-binding protein
APP_32940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP_32950	COG4509	Sortase family
APP_32990	COG5386	Cell surface protein
APP_33020	COG1126	abc transporter atp-binding protein
APP_33040	COG2508	Transcriptional regulator
APP_33040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APP_33050	COG0686	Belongs to the AlaDH PNT family
APP_33070	COG2329	Antibiotic biosynthesis monooxygenase
APP_33080	COG0579	oxidoreductase
APP_33090	COG1309	transcriptional regulator
APP_33110	COG0477	Major facilitator Superfamily
APP_33130	COG0583	DNA-binding transcription factor activity
APP_33140	COG2031	fatty acid transporter
APP_33280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APP_33400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APP_33420	COG1597	lipid kinase activity
APP_33440	COG0154	amidase activity
APP_33470	COG4851	CamS sex pheromone cAM373 precursor
APP_33480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APP_33490	COG0210	DNA helicase
APP_33500	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
APP_33510	COG4496	protein, YerC YecD
APP_33520	COG1470	cell adhesion involved in biofilm formation
APP_33530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APP_33540	COG0151	Belongs to the GarS family
APP_33550	COG0138	bifunctional purine biosynthesis protein purh
APP_33560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APP_33570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APP_33580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APP_33590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APP_33600	COG0047	phosphoribosylformylglycinamidine synthase activity
APP_33610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APP_33620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APP_33630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APP_33640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APP_33650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APP_33660	COG2252	PERMEase
APP_33680	COG0519	Catalyzes the synthesis of GMP from XMP
APP_33680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APP_33690	COG1305	Transglutaminase-like
APP_33700	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
APP_33710	COG0714	Associated with various cellular activities
APP_33790	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APP_33810	COG0410	ABC transporter
APP_33840	COG0559	Belongs to the binding-protein-dependent transport system permease family
APP_33870	COG1012	belongs to the aldehyde dehydrogenase family
APP_33890	COG1012	belongs to the aldehyde dehydrogenase family
APP_33920	COG0179	Fumarylacetoacetate (FAA) hydrolase
APP_33930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APP_33940	COG0196	riboflavin kinase activity
APP_33960	COG1012	belongs to the aldehyde dehydrogenase family
APP_33990	COG0583	DNA-binding transcription factor activity
APP_34020	COG0477	Major facilitator Superfamily
APP_34060	COG1063	alcohol dehydrogenase
APP_34080	COG1063	alcohol dehydrogenase
APP_34090	COG3775	system Galactitol-specific IIC component
APP_34100	COG3414	Phosphotransferase system galactitol-specific IIB component
APP_34110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_34110	COG2213	PTS system mannitol-specific
APP_34150	COG2356	endonuclease I
APP_34160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP_34170	COG0386	Belongs to the glutathione peroxidase family
APP_34200	COG3732	PTS system glucitol sorbitol-specific
APP_34210	COG3730	PTS system glucitol sorbitol-specific
APP_34260	COG5002	protein histidine kinase activity
APP_34270	COG0745	RESPONSE REGULATOR receiver
APP_34360	COG1131	(ABC) transporter
APP_34380	COG1595	DNA-templated transcription, initiation
APP_34390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APP_34400	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_34440	COG1012	belongs to the aldehyde dehydrogenase family
APP_34450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APP_34470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APP_34480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APP_34520	COG0318	PFAM AMP-dependent synthetase and ligase
APP_34530	COG2030	dehydratase
APP_34540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP_34570	COG0411	ABC transporter
APP_34650	COG4720	Psort location CytoplasmicMembrane, score
APP_34680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APP_34750	COG1442	glycosyl transferase family 8
APP_34750	COG1216	Glycosyl transferase, family 2
APP_34800	COG2089	acid synthase
APP_34850	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
APP_34860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APP_34870	COG1086	Polysaccharide biosynthesis protein
APP_34880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APP_34890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APP_34900	COG4464	protein tyrosine phosphatase activity
APP_34910	COG0489	protein tyrosine kinase activity
APP_34920	COG3944	biosynthesis protein
APP_34950	COG4715	Zinc finger, swim domain protein
APP_34960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APP_34970	COG0629	single-stranded DNA binding
APP_34990	COG1476	TRANSCRIPTIONal
APP_35040	COG4786	Flagellar basal body rod
APP_35050	COG4786	Flagellar basal body rod
APP_35060	COG1077	Cell shape determining protein MreB Mrl
APP_35070	COG1609	Transcriptional regulator
APP_35080	COG1984	allophanate hydrolase subunit 2
APP_35090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APP_35100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APP_35110	COG1247	-acetyltransferase
APP_35120	COG0739	heme binding
APP_35140	COG2385	sporulation resulting in formation of a cellular spore
APP_35150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APP_35170	COG4836	Membrane
APP_35180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APP_35190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APP_35200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APP_35210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APP_35220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APP_35230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APP_35240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APP_35250	COG0356	it plays a direct role in the translocation of protons across the membrane
APP_35280	COG1404	Belongs to the peptidase S8 family
APP_35290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APP_35300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APP_35320	COG0698	ribose 5-phosphate isomerase
APP_35330	COG0840	transmembrane signaling receptor activity
APP_35340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APP_35350	COG1971	Probably functions as a manganese efflux pump
APP_35360	COG0009	L-threonylcarbamoyladenylate synthase
APP_35390	COG2890	protein-(glutamine-N5) methyltransferase activity
APP_35400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APP_35410	COG0789	Transcriptional regulator
APP_35440	COG1435	thymidine kinase activity
APP_35450	COG0254	rRNA binding
APP_35460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APP_35470	COG1494	fructose-1,6-bisphosphatase
APP_35480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APP_35490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APP_35500	COG0191	fructose-bisphosphate aldolase activity
APP_35510	COG2204	response regulator
APP_35520	COG4821	SIS domain
APP_35540	COG0504	CTP synthase activity
APP_35550	COG3343	RNA polymerase activity
APP_35560	COG0247	lactate metabolic process
APP_35560	COG2181	nitrate reductase activity
APP_35570	COG1595	DNA-templated transcription, initiation
APP_35580	COG0018	arginyl-trna synthetase
APP_35590	COG4506	Protein conserved in bacteria
APP_35600	COG0010	Belongs to the arginase family
APP_35610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APP_35620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP_35660	COG4844	belongs to the
APP_35670	COG1078	dGTPase activity
APP_35680	COG3465	dGTPase activity
APP_35690	COG1994	Peptidase M50
APP_35720	COG0280	phosphate acetyltransferase
APP_35740	COG3773	Cell wall hydrolase
APP_35760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APP_35770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APP_35790	COG2363	Small membrane protein
APP_35810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APP_35870	COG1309	transcriptional regulator
APP_35880	COG0351	phosphomethylpyrimidine kinase
APP_35890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APP_35900	COG0584	glycerophosphoryl diester phosphodiesterase
APP_35920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP_35930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APP_35970	COG0778	Nitroreductase
APP_35980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP_36000	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
APP_36050	COG0561	phosphatase activity
APP_36060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APP_36080	COG0596	Alpha beta hydrolase
APP_36100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP_36110	COG0410	ABC transporter
APP_36150	COG0683	leucine binding
APP_36160	COG1082	Xylose isomerase domain protein TIM barrel
APP_36170	COG0673	inositol 2-dehydrogenase activity
APP_36180	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP_36190	COG1129	ABC transporter
APP_36200	COG0673	inositol 2-dehydrogenase activity
APP_36220	COG1082	Xylose isomerase domain protein TIM barrel
APP_36230	COG1609	Transcriptional regulator
APP_36240	COG3764	Sortase (surface protein transpeptidase)
APP_36250	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP_36260	COG0022	dehydrogenase e1 component
APP_36270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APP_36370	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APP_36380	COG0737	Belongs to the 5'-nucleotidase family
APP_36410	COG0456	acetyltransferase
APP_36420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APP_36420	COG3153	acetyltransferase
APP_36460	COG0745	RESPONSE REGULATOR receiver
APP_36470	COG2205	protein histidine kinase activity
APP_36480	COG1136	(ABC) transporter
APP_36490	COG0577	efflux transmembrane transporter activity
APP_36500	COG2910	NAD(P)H-binding
APP_36510	COG1959	2 iron, 2 sulfur cluster binding
APP_36520	COG0784	Response regulator, receiver
APP_36530	COG4191	Histidine kinase
APP_36570	COG2213	PTS system mannitol-specific
APP_36590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP_36600	COG0246	Mannitol dehydrogenase
APP_36610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APP_36620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APP_36630	COG1349	DNA-binding transcription factor activity
APP_36660	COG1131	(ABC) transporter
APP_36670	COG2072	flavoprotein involved in K transport
APP_36690	COG1607	acyl-coa hydrolase
APP_36710	COG0583	DNA-binding transcription factor activity
APP_36750	COG3973	AAA domain
APP_36800	COG1620	l-lactate permease
APP_36900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APP_36920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP_36930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APP_36940	COG4853	Protein conserved in bacteria
APP_36960	COG5002	protein histidine kinase activity
APP_36970	COG0745	RESPONSE REGULATOR receiver
APP_36980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APP_36990	COG0305	Participates in initiation and elongation during chromosome replication
APP_37000	COG0359	binds to the 23S rRNA
APP_37010	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
APP_37020	COG4241	membrane
APP_37030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APP_37040	COG0629	single-stranded DNA binding
APP_37050	COG0360	Binds together with S18 to 16S ribosomal RNA
APP_37060	COG0012	GTP binding
APP_37070	COG4481	Protein conserved in bacteria
APP_37090	COG1475	DNA binding
APP_37100	COG1192	Involved in chromosome partitioning
APP_37110	COG1475	DNA binding
APP_37120	COG0357	Ribosomal RNA small subunit methyltransferase G
APP_37130	COG0445	tRNA wobble uridine modification
APP_37140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APP_37150	COG1847	R3H domain protein
APP_37160	COG0706	membrane insertase activity
APP_37170	COG0594	ribonuclease P activity
APP_37180	COG0230	Belongs to the bacterial ribosomal protein bL34 family