locus-tag	class	description
NRE15_00005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRE15_00015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRE15_00025	COG4608	Belongs to the ABC transporter superfamily
NRE15_00030	COG0601	transmembrane transport
NRE15_00035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_00050	COG1196	nuclear chromosome segregation
NRE15_00055	COG0561	phosphatase activity
NRE15_00060	COG0552	protein localization to endoplasmic reticulum
NRE15_00065	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NRE15_00070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRE15_00075	COG0228	four-way junction DNA binding
NRE15_00080	COG1837	Belongs to the UPF0109 family
NRE15_00085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRE15_00095	COG0335	large ribosomal subunit rRNA binding
NRE15_00110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRE15_00115	COG0561	phosphatase activity
NRE15_00120	COG2151	metal-sulfur cluster biosynthetic enzyme
NRE15_00130	COG0542	response to heat
NRE15_00135	COG0667	Aldo Keto reductase
NRE15_00145	COG1131	(ABC) transporter
NRE15_00150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRE15_00165	COG2207	Transcriptional regulator
NRE15_00220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRE15_00235	COG4555	ABC transporter
NRE15_00240	COG0435	Glutathione S-transferase
NRE15_00245	COG0346	lactoylglutathione lyase activity
NRE15_00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRE15_00270	COG2217	Heavy metal translocating P-type atpase
NRE15_00275	COG2382	esterase
NRE15_00280	COG2131	deaminase
NRE15_00295	COG4129	membrane
NRE15_00305	COG0180	Tryptophanyl-tRNA synthetase
NRE15_00310	COG1393	Belongs to the ArsC family
NRE15_00320	COG0822	iron-sulfur transferase activity
NRE15_00325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRE15_00330	COG0719	Fe-S assembly protein
NRE15_00340	COG4862	establishment of competence for transformation
NRE15_00350	COG1164	Oligoendopeptidase f
NRE15_00355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRE15_00360	COG0510	thiamine kinase activity
NRE15_00370	COG1363	Peptidase, m42
NRE15_00375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRE15_00385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRE15_00390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRE15_00390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRE15_00395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRE15_00400	COG0237	dephospho-CoA kinase activity
NRE15_00415	COG1484	DNA-dependent DNA replication
NRE15_00425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRE15_00430	COG1686	Belongs to the peptidase S11 family
NRE15_00440	COG2514	catechol 2,3-dioxygenase activity
NRE15_00450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRE15_00455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRE15_00470	COG0077	Prephenate dehydratase
NRE15_00470	COG1605	Chorismate mutase
NRE15_00480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NRE15_00490	COG2357	RelA SpoT domain protein
NRE15_00495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRE15_00505	COG0564	pseudouridine synthase activity
NRE15_00510	COG2239	Acts as a magnesium transporter
NRE15_00520	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRE15_00540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_00545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRE15_00550	COG0438	transferase activity, transferring glycosyl groups
NRE15_00555	COG2084	Dehydrogenase
NRE15_00570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRE15_00575	COG1534	Rna-binding protein
NRE15_00580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRE15_00585	COG1713	HD superfamily hydrolase involved in NAD metabolism
NRE15_00590	COG0799	negative regulation of ribosome biogenesis
NRE15_00595	COG2226	methyltransferase
NRE15_00600	COG1323	Belongs to the UPF0348 family
NRE15_00610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRE15_00615	COG0740	serine-type endopeptidase activity
NRE15_00625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRE15_00630	COG0126	phosphoglycerate kinase activity
NRE15_00645	COG0148	phosphopyruvate hydratase activity
NRE15_00655	COG2610	gluconate transmembrane transporter activity
NRE15_00665	COG1414	Transcriptional regulator
NRE15_00670	COG1942	4-Oxalocrotonate Tautomerase
NRE15_00675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRE15_00680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NRE15_00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRE15_00710	COG0482	sulfurtransferase activity
NRE15_00720	COG0557	exoribonuclease II activity
NRE15_00725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRE15_00750	COG4537	Required for transformation and DNA binding
NRE15_00760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRE15_00765	COG5503	Protein of unknown function (DUF1447)
NRE15_00775	COG0006	proline dipeptidase activity
NRE15_00780	COG1302	Protein conserved in bacteria
NRE15_00785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRE15_00800	COG0577	efflux transmembrane transporter activity
NRE15_00800	COG1136	(ABC) transporter
NRE15_00810	COG1132	(ABC) transporter
NRE15_00815	COG3158	transport of potassium into the cell
NRE15_00820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRE15_00830	COG3279	Response regulator of the LytR AlgR family
NRE15_00845	COG1132	(ABC) transporter
NRE15_00855	COG1570	exodeoxyribonuclease VII activity
NRE15_00860	COG1722	exodeoxyribonuclease VII activity
NRE15_00865	COG0142	geranyltranstransferase activity
NRE15_00870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NRE15_00875	COG0497	DNA recombination
NRE15_00880	COG0584	glycerophosphoryl diester phosphodiesterase
NRE15_00890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRE15_00895	COG0242	peptide deformylase activity
NRE15_00905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NRE15_00920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRE15_00930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NRE15_00935	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_00940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRE15_00950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRE15_00955	COG0439	Biotin carboxylase
NRE15_00960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRE15_00965	COG0825	malonyl-CoA metabolic process
NRE15_00970	COG4166	transmembrane transport
NRE15_00975	COG0601	transmembrane transport
NRE15_00980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_00985	COG0444	Belongs to the ABC transporter superfamily
NRE15_00990	COG4608	Belongs to the ABC transporter superfamily
NRE15_01025	COG0483	inositol monophosphate 1-phosphatase activity
NRE15_01030	COG1217	gtp-binding protein TYPA
NRE15_01035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRE15_01040	COG0772	Belongs to the SEDS family
NRE15_01045	COG4471	UPF0298 protein
NRE15_01050	COG0742	ribosomal rna small subunit methyltransferase
NRE15_01055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRE15_01060	COG0488	(ABC) transporter
NRE15_01065	COG2183	response to ionizing radiation
NRE15_01070	COG2333	competence protein COMEC
NRE15_01070	COG0658	competence protein
NRE15_01085	COG0604	alcohol dehydrogenase
NRE15_01095	COG1846	Transcriptional regulator
NRE15_01100	COG0346	lactoylglutathione lyase activity
NRE15_01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NRE15_01130	COG0596	Alpha beta hydrolase
NRE15_01145	COG0737	Belongs to the 5'-nucleotidase family
NRE15_01150	COG4470	Protein conserved in bacteria
NRE15_01155	COG0647	UMP catabolic process
NRE15_01165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRE15_01170	COG0492	ferredoxin-NADP+ reductase activity
NRE15_01175	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NRE15_01180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRE15_01185	COG1185	polyribonucleotide nucleotidyltransferase activity
NRE15_01190	COG0166	Belongs to the GPI family
NRE15_01315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRE15_01330	COG1054	Belongs to the UPF0176 family
NRE15_01335	COG1597	lipid kinase activity
NRE15_01350	COG0328	RNA-DNA hybrid ribonuclease activity
NRE15_01355	COG0116	Belongs to the methyltransferase superfamily
NRE15_01365	COG3599	regulation of cell shape
NRE15_01375	COG2264	protein methyltransferase activity
NRE15_01380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRE15_01385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRE15_01390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRE15_01395	COG1490	D-aminoacyl-tRNA deacylase activity
NRE15_01400	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRE15_01405	COG0124	histidyl-tRNA synthetase
NRE15_01410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRE15_01415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRE15_01430	COG0156	8-amino-7-oxononanoate synthase activity
NRE15_01435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRE15_01465	COG1131	(ABC) transporter
NRE15_01470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRE15_01475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRE15_01480	COG0509	glycine decarboxylation via glycine cleavage system
NRE15_01485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRE15_01490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRE15_01505	COG1610	YqeY-like protein
NRE15_01510	COG1702	phosphate starvation-inducible protein PhoH
NRE15_01520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRE15_01525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRE15_01530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NRE15_01535	COG1381	Involved in DNA repair and RecF pathway recombination
NRE15_01555	COG4152	abc transporter atp-binding protein
NRE15_01560	COG1668	transmembrane transport
NRE15_01570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRE15_01595	COG1131	(ABC) transporter
NRE15_01610	COG0668	transmembrane transport
NRE15_01620	COG4980	gas vesicle protein
NRE15_01625	COG1609	Transcriptional regulator
NRE15_01640	COG0511	ligase activity, forming carbon-carbon bonds
NRE15_01645	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NRE15_01665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NRE15_01670	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NRE15_01675	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_01675	COG1388	LysM domain
NRE15_01680	COG0495	leucyl-tRNA aminoacylation
NRE15_01685	COG2244	polysaccharide biosynthetic process
NRE15_01690	COG1187	pseudouridine synthase activity
NRE15_01695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRE15_01700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRE15_01710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRE15_01715	COG0072	phenylalanine-tRNA ligase activity
NRE15_01715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRE15_01725	COG1420	regulation of RNA biosynthetic process
NRE15_01730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRE15_01735	COG0443	Heat shock 70 kDa protein
NRE15_01740	COG0484	heat shock protein binding
NRE15_01745	COG3711	transcriptional antiterminator
NRE15_01765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRE15_01770	COG0481	GTPase activity
NRE15_01775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRE15_01785	COG0488	(ABC) transporter
NRE15_01795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRE15_01810	COG1132	(ABC) transporter
NRE15_01815	COG1132	(ABC) transporter
NRE15_01860	COG1131	(ABC) transporter
NRE15_01865	COG1136	(ABC) transporter
NRE15_01865	COG0577	efflux transmembrane transporter activity
NRE15_01870	COG1272	protein, Hemolysin III
NRE15_01880	COG4479	Belongs to the UPF0346 family
NRE15_01885	COG0813	purine-nucleoside phosphorylase activity
NRE15_01890	COG3409	Peptidoglycan-binding domain 1 protein
NRE15_01890	COG0793	Belongs to the peptidase S41A family
NRE15_01900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRE15_01905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRE15_01910	COG0758	DNA mediated transformation
NRE15_01915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRE15_01930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NRE15_01940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NRE15_01945	COG0187	DNA topoisomerase II activity
NRE15_01950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NRE15_01955	COG1882	Formate acetyltransferase
NRE15_01960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRE15_01975	COG1227	inorganic diphosphatase activity
NRE15_01980	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NRE15_01990	COG4120	Belongs to the binding-protein-dependent transport system permease family
NRE15_02005	COG2205	protein histidine kinase activity
NRE15_02005	COG0745	RESPONSE REGULATOR receiver
NRE15_02005	COG3292	Two component regulator propeller
NRE15_02035	COG2017	converts alpha-aldose to the beta-anomer
NRE15_02045	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NRE15_02060	COG1012	belongs to the aldehyde dehydrogenase family
NRE15_02060	COG1454	alcohol dehydrogenase
NRE15_02065	COG1408	metallophosphoesterase
NRE15_02080	COG1131	(ABC) transporter
NRE15_02105	COG0288	reversible hydration of carbon dioxide
NRE15_02110	COG1247	-acetyltransferase
NRE15_02115	COG2133	pyrroloquinoline quinone binding
NRE15_02125	COG3842	ATPase activity
NRE15_02140	COG1484	DNA-dependent DNA replication
NRE15_02155	COG1131	(ABC) transporter
NRE15_02165	COG1115	amino acid carrier protein
NRE15_02170	COG1126	abc transporter atp-binding protein
NRE15_02175	COG0765	amino acid transport
NRE15_02195	COG3344	reverse transcriptase
NRE15_02215	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRE15_02220	COG0425	Belongs to the sulfur carrier protein TusA family
NRE15_02220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRE15_02225	COG1937	Protein conserved in bacteria
NRE15_02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
NRE15_02240	COG1121	(ABC) transporter
NRE15_02245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRE15_02250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRE15_02265	COG1464	Belongs to the NlpA lipoprotein family
NRE15_02270	COG2011	ABC-type metal ion transport system permease component
NRE15_02275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRE15_02310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NRE15_02345	COG2135	peptidase activity
NRE15_02350	COG0469	pyruvate kinase activity
NRE15_02355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRE15_02365	COG0564	pseudouridine synthase activity
NRE15_02385	COG1074	ATP-dependent DNA helicase activity
NRE15_02390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NRE15_02395	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRE15_02400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRE15_02405	COG2384	SAM-dependent methyltransferase
NRE15_02410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRE15_02415	COG0358	DNA primase activity
NRE15_02420	COG2270	Major facilitator Superfamily
NRE15_02425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NRE15_02430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRE15_02435	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRE15_02445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRE15_02450	COG3935	DnaD domain protein
NRE15_02465	COG1199	ATP-dependent helicase activity
NRE15_02465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRE15_02490	COG3344	reverse transcriptase
NRE15_02500	COG1160	GTP binding
NRE15_02505	COG0539	negative regulation of cytoplasmic translation
NRE15_02510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRE15_02515	COG3942	CHAP domain
NRE15_02525	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NRE15_02530	COG1187	pseudouridine synthase activity
NRE15_02535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRE15_02555	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRE15_02570	COG0018	arginyl-trna synthetase
NRE15_02580	COG0205	6-phosphofructokinase activity
NRE15_02585	COG0587	DNA-directed DNA polymerase activity
NRE15_02595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NRE15_02600	COG2255	four-way junction helicase activity
NRE15_02605	COG0632	four-way junction helicase activity
NRE15_02615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NRE15_02620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NRE15_02625	COG1692	metallophosphoesterase
NRE15_02635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRE15_02640	COG1058	Belongs to the CinA family
NRE15_02640	COG1546	Belongs to the CinA family
NRE15_02645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRE15_02650	COG1426	Protein conserved in bacteria
NRE15_02655	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRE15_02660	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRE15_02665	COG3845	ABC transporter
NRE15_02670	COG1744	ABC transporter substrate-binding protein PnrA-like
NRE15_02675	COG1674	ftsk spoiiie
NRE15_02680	COG1254	Belongs to the acylphosphatase family
NRE15_02685	COG0706	membrane insertase activity
NRE15_02695	COG0745	RESPONSE REGULATOR receiver
NRE15_02705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRE15_02710	COG1940	carbohydrate kinase activity
NRE15_02720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRE15_02735	COG0105	UTP biosynthetic process
NRE15_02740	COG0768	penicillin binding
NRE15_02755	COG0513	Belongs to the DEAD box helicase family
NRE15_02760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NRE15_02765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRE15_02770	COG4109	DRTGG domain
NRE15_02790	COG1862	Preprotein translocase
NRE15_02795	COG0343	queuine tRNA-ribosyltransferase activity
NRE15_02810	COG1132	(ABC) transporter
NRE15_02815	COG1132	(ABC) transporter
NRE15_02830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRE15_02835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRE15_02840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NRE15_02840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NRE15_02850	COG0300	oxidoreductase activity
NRE15_02855	COG1234	tRNA 3'-trailer cleavage
NRE15_02860	COG2755	lipolytic protein G-D-S-L family
NRE15_02860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NRE15_02870	COG0751	glycine-tRNA ligase activity
NRE15_02875	COG0752	glycyl-tRNA synthetase alpha subunit
NRE15_02885	COG0686	Belongs to the AlaDH PNT family
NRE15_02890	COG3118	belongs to the thioredoxin family
NRE15_02895	COG1193	negative regulation of DNA recombination
NRE15_02905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NRE15_02910	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRE15_02915	COG0726	polysaccharide deacetylase
NRE15_02920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRE15_02925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRE15_02930	COG0196	riboflavin kinase activity
NRE15_02935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRE15_02950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRE15_02965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NRE15_02970	COG0195	Participates in both transcription termination and antitermination
NRE15_02975	COG0779	Required for maturation of 30S ribosomal subunits
NRE15_02980	COG2032	superoxide dismutase activity
NRE15_02985	COG0431	NADPH-dependent FMN reductase
NRE15_02995	COG1126	abc transporter atp-binding protein
NRE15_03005	COG2176	DNA-directed DNA polymerase activity
NRE15_03010	COG0750	zinc metalloprotease
NRE15_03020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRE15_03025	COG0233	cytoplasmic translational termination
NRE15_03035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NRE15_03040	COG0528	UMP kinase activity
NRE15_03045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRE15_03055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRE15_03075	COG4864	UPF0365 protein
NRE15_03085	COG0628	permease
NRE15_03095	COG0574	Belongs to the PEP-utilizing enzyme family
NRE15_03095	COG3848	Pyruvate phosphate dikinase
NRE15_03100	COG1183	phosphatidylcholine synthase activity
NRE15_03105	COG0688	phosphatidylethanolamine metabolic process
NRE15_03115	COG0574	Belongs to the PEP-utilizing enzyme family
NRE15_03115	COG3848	Pyruvate phosphate dikinase
NRE15_03130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRE15_03140	COG3339	Conserved Protein
NRE15_03145	COG2222	sugar isomerase
NRE15_03150	COG3684	Belongs to the aldolase LacD family
NRE15_03155	COG2188	Transcriptional regulator
NRE15_03165	COG3976	FMN-binding domain protein
NRE15_03165	COG1053	succinate dehydrogenase
NRE15_03165	COG0431	NADPH-dependent FMN reductase
NRE15_03170	COG0431	NADPH-dependent FMN reductase
NRE15_03170	COG1053	succinate dehydrogenase
NRE15_03170	COG3976	FMN-binding domain protein
NRE15_03180	COG0662	Cupin 2, conserved barrel domain protein
NRE15_03190	COG0708	Exodeoxyribonuclease III
NRE15_03215	COG1201	RNA secondary structure unwinding
NRE15_03245	COG0514	ATP-dependent DNA helicase (RecQ)
NRE15_03250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRE15_03270	COG2731	YhcH YjgK YiaL family protein
NRE15_03315	COG1131	(ABC) transporter
NRE15_03325	COG4876	unkown
NRE15_03330	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NRE15_03360	COG1733	regulation of RNA biosynthetic process
NRE15_03365	COG2910	NAD(P)H-binding
NRE15_03370	COG0471	metal ion transport
NRE15_03370	COG0490	domain, Protein
NRE15_03385	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRE15_03390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRE15_03395	COG0183	Belongs to the thiolase family
NRE15_03400	COG1024	Enoyl-CoA hydratase
NRE15_03445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NRE15_03475	COG1733	regulation of RNA biosynthetic process
NRE15_03500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRE15_03505	COG1733	regulation of RNA biosynthetic process
NRE15_03515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NRE15_03520	COG1122	ATPase activity
NRE15_03525	COG1122	ATPase activity
NRE15_03545	COG1131	(ABC) transporter
NRE15_03555	COG2197	response regulator
NRE15_03560	COG4585	Histidine kinase
NRE15_03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRE15_03580	COG0753	catalase activity
NRE15_03600	COG1136	(ABC) transporter
NRE15_03610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRE15_03615	COG2315	Protein conserved in bacteria
NRE15_03635	COG1846	Transcriptional regulator
NRE15_03640	COG4224	UPF0291 protein
NRE15_03645	COG2964	Protein conserved in bacteria
NRE15_03660	COG1473	amidohydrolase
NRE15_03690	COG2207	Transcriptional regulator
NRE15_03695	COG3250	beta-galactosidase activity
NRE15_03700	COG0110	maltose O-acetyltransferase activity
NRE15_03705	COG3345	alpha-galactosidase
NRE15_03720	COG2084	Dehydrogenase
NRE15_03725	COG1929	Belongs to the glycerate kinase type-1 family
NRE15_03730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRE15_03745	COG2610	gluconate transmembrane transporter activity
NRE15_03750	COG3835	regulator
NRE15_03780	COG0351	phosphomethylpyrimidine kinase
NRE15_03795	COG1053	succinate dehydrogenase
NRE15_03795	COG3976	FMN-binding domain protein
NRE15_03805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRE15_03815	COG0583	DNA-binding transcription factor activity
NRE15_03820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRE15_03830	COG1309	transcriptional regulator
NRE15_03840	COG4372	Transposase
NRE15_03845	COG4895	conserved protein (DUF2196)
NRE15_03850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRE15_03860	COG0277	FAD linked oxidase domain protein
NRE15_03880	COG1053	succinate dehydrogenase
NRE15_03885	COG1473	amidohydrolase
NRE15_03895	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRE15_03900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NRE15_03915	COG3012	SEC-C Motif Domain Protein
NRE15_03925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRE15_03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRE15_03965	COG0702	epimerase
NRE15_03970	COG0583	DNA-binding transcription factor activity
NRE15_04055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NRE15_04115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRE15_04135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRE15_04140	COG0569	domain protein
NRE15_04155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRE15_04160	COG0460	homoserine dehydrogenase
NRE15_04175	COG1131	(ABC) transporter
NRE15_04225	COG1134	teichoic acid transport
NRE15_04225	COG1388	LysM domain
NRE15_04230	COG4824	toxin secretion phage lysis holin
NRE15_04255	COG2020	methyltransferase activity
NRE15_04300	COG4695	Portal protein
NRE15_04335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NRE15_04360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRE15_04435	COG0798	PFAM Bile acid sodium symporter
NRE15_04490	COG1263	PTS System
NRE15_04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_04490	COG2190	(PTS) system
NRE15_04500	COG2723	6-phospho-beta-galactosidase activity
NRE15_04520	COG1136	(ABC) transporter
NRE15_04535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRE15_04555	COG1126	abc transporter atp-binding protein
NRE15_04560	COG0765	amino acid transport
NRE15_04565	COG0523	cobalamin synthesis protein
NRE15_04570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRE15_04580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRE15_04585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRE15_04595	COG1131	(ABC) transporter
NRE15_04625	COG2184	nucleotidyltransferase activity
NRE15_04635	COG0745	RESPONSE REGULATOR receiver
NRE15_04650	COG2205	protein histidine kinase activity
NRE15_04670	COG3189	MarR family transcriptional regulator
NRE15_04735	COG0083	homoserine kinase activity
NRE15_04740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRE15_04745	COG0460	homoserine dehydrogenase
NRE15_04755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRE15_04780	COG4989	oxidoreductase activity
NRE15_04785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRE15_04785	COG1017	nitric oxide dioxygenase activity
NRE15_04790	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NRE15_04790	COG3976	FMN-binding domain protein
NRE15_04795	COG1464	Belongs to the NlpA lipoprotein family
NRE15_04805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRE15_04810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NRE15_04815	COG1687	branched-chain amino acid
NRE15_04825	COG3768	UPF0283 membrane protein
NRE15_04835	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_04845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NRE15_04850	COG0427	acetyl-CoA hydrolase
NRE15_04880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRE15_04885	COG0596	Alpha beta hydrolase
NRE15_04885	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRE15_04890	COG1609	Transcriptional regulator
NRE15_04905	COG1175	transmembrane transport
NRE15_04920	COG0395	ABC-type sugar transport system, permease component
NRE15_04925	COG1175	transmembrane transport
NRE15_04950	COG4372	Transposase
NRE15_04955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRE15_04960	COG0517	IMP dehydrogenase activity
NRE15_04965	COG0574	Belongs to the PEP-utilizing enzyme family
NRE15_04965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRE15_04970	COG0246	Mannitol dehydrogenase
NRE15_04975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_04980	COG3711	transcriptional antiterminator
NRE15_04990	COG0363	glucosamine-6-phosphate deaminase activity
NRE15_05000	COG1737	Transcriptional regulator
NRE15_05005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_05005	COG1263	PTS System
NRE15_05010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NRE15_05020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRE15_05025	COG3459	Glycosyltransferase 36 associated
NRE15_05030	COG0395	ABC-type sugar transport system, permease component
NRE15_05035	COG1175	transmembrane transport
NRE15_05060	COG0475	glutathione-regulated potassium exporter activity
NRE15_05080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRE15_05090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRE15_05095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRE15_05100	COG0151	Belongs to the GarS family
NRE15_05105	COG0138	bifunctional purine biosynthesis protein purh
NRE15_05110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRE15_05115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRE15_05145	COG2723	6-phospho-beta-galactosidase activity
NRE15_05150	COG0383	alpha-mannosidase activity
NRE15_05170	COG1446	asparaginase
NRE15_05175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRE15_05190	COG0673	inositol 2-dehydrogenase activity
NRE15_05200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRE15_05205	COG1609	Transcriptional regulator
NRE15_05220	COG0395	ABC-type sugar transport system, permease component
NRE15_05225	COG4209	transmembrane transport
NRE15_05230	COG5578	integral membrane protein
NRE15_05240	COG0395	ABC-type sugar transport system, permease component
NRE15_05245	COG4209	transmembrane transport
NRE15_05265	COG2723	6-phospho-beta-galactosidase activity
NRE15_05270	COG2190	(PTS) system
NRE15_05270	COG1263	PTS System
NRE15_05270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_05275	COG3711	transcriptional antiterminator
NRE15_05310	COG2217	Heavy metal translocating P-type atpase
NRE15_05330	COG3711	transcriptional antiterminator
NRE15_05345	COG0702	epimerase
NRE15_05355	COG4221	oxidoreductase activity
NRE15_05365	COG0583	DNA-binding transcription factor activity
NRE15_05385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRE15_05400	COG3246	L-lysine catabolic process to acetate
NRE15_05410	COG0697	spore germination
NRE15_05425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRE15_05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRE15_05440	COG3835	regulator
NRE15_05445	COG0183	Belongs to the thiolase family
NRE15_05450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NRE15_05455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NRE15_05460	COG2031	fatty acid transporter
NRE15_05475	COG0471	metal ion transport
NRE15_05485	COG2267	carboxylic ester hydrolase activity
NRE15_05490	COG3246	L-lysine catabolic process to acetate
NRE15_05495	COG2207	Transcriptional regulator
NRE15_05500	COG3345	alpha-galactosidase
NRE15_05505	COG1653	transport
NRE15_05510	COG1175	transmembrane transport
NRE15_05515	COG0395	ABC-type sugar transport system, permease component
NRE15_05520	COG0366	Alpha amylase catalytic
NRE15_05525	COG1876	peptidase activity
NRE15_05570	COG1609	Transcriptional regulator
NRE15_05580	COG1874	Beta-galactosidase
NRE15_05590	COG3833	ABC-type maltose transport systems, permease component
NRE15_05595	COG1175	transmembrane transport
NRE15_05600	COG2182	Extracellular solute-binding protein
NRE15_05610	COG1193	negative regulation of DNA recombination
NRE15_05625	COG1175	transmembrane transport
NRE15_05635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRE15_05650	COG1349	DNA-binding transcription factor activity
NRE15_05655	COG0758	DNA mediated transformation
NRE15_05660	COG1653	transport
NRE15_05665	COG3458	cephalosporin-C deacetylase activity
NRE15_05680	COG4221	oxidoreductase activity
NRE15_05715	COG0395	ABC-type sugar transport system, permease component
NRE15_05720	COG4209	transmembrane transport
NRE15_05730	COG2207	Transcriptional regulator
NRE15_05730	COG4753	response regulator
NRE15_05735	COG2972	Histidine kinase
NRE15_05745	COG0431	NADPH-dependent FMN reductase
NRE15_05745	COG1053	succinate dehydrogenase
NRE15_05745	COG3976	FMN-binding domain protein
NRE15_05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRE15_05790	COG0667	Aldo Keto reductase
NRE15_05840	COG0464	growth
NRE15_05865	COG3394	polysaccharide catabolic process
NRE15_05880	COG3715	PTS system
NRE15_05885	COG3716	PTS system mannose fructose sorbose family IID component
NRE15_05890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRE15_05895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRE15_05900	COG1737	Transcriptional regulator
NRE15_05910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_05925	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRE15_05930	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NRE15_05935	COG2723	6-phospho-beta-galactosidase activity
NRE15_05940	COG1263	PTS System
NRE15_05940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_05940	COG2190	(PTS) system
NRE15_05945	COG3711	transcriptional antiterminator
NRE15_06030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_06040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_06045	COG2723	6-phospho-beta-galactosidase activity
NRE15_06050	COG1737	Transcriptional regulator
NRE15_06100	COG1484	DNA-dependent DNA replication
NRE15_06160	COG1484	DNA-dependent DNA replication
NRE15_06190	COG1484	DNA-dependent DNA replication
NRE15_06200	COG1484	DNA-dependent DNA replication
NRE15_06205	COG4974	Belongs to the 'phage' integrase family
NRE15_06215	COG1484	DNA-dependent DNA replication
NRE15_06240	COG1216	Glycosyl transferase, family 2
NRE15_06270	COG1086	Polysaccharide biosynthesis protein
NRE15_06285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRE15_06290	COG0489	protein tyrosine kinase activity
NRE15_06305	COG1086	Polysaccharide biosynthesis protein
NRE15_06330	COG0438	transferase activity, transferring glycosyl groups
NRE15_06335	COG0489	protein tyrosine kinase activity
NRE15_06355	COG0728	peptidoglycan biosynthetic process
NRE15_06380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRE15_06385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRE15_06395	COG3177	Filamentation induced by cAMP protein fic
NRE15_06430	COG0395	ABC-type sugar transport system, permease component
NRE15_06435	COG1175	transmembrane transport
NRE15_06455	COG1486	melibiose metabolic process
NRE15_06485	COG4372	Transposase
NRE15_06490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRE15_06495	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NRE15_06510	COG4753	response regulator
NRE15_06510	COG2207	Transcriptional regulator
NRE15_06515	COG4372	Transposase
NRE15_06530	COG0366	Alpha amylase catalytic
NRE15_06535	COG3250	beta-galactosidase activity
NRE15_06555	COG1653	transport
NRE15_06565	COG0395	ABC-type sugar transport system, permease component
NRE15_06570	COG4209	transmembrane transport
NRE15_06575	COG2843	Capsule synthesis protein
NRE15_06600	COG2183	response to ionizing radiation
NRE15_06605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRE15_06610	COG2252	PERMEase
NRE15_06620	COG1301	dicarboxylic acid transport
NRE15_06635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRE15_06645	COG2271	Major facilitator Superfamily
NRE15_06650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRE15_06655	COG2508	Transcriptional regulator
NRE15_06660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NRE15_06665	COG3257	ureidoglycine aminohydrolase activity
NRE15_06685	COG0564	pseudouridine synthase activity
NRE15_06690	COG1388	LysM domain
NRE15_06690	COG3584	3D domain protein
NRE15_06705	COG0436	Aminotransferase
NRE15_06710	COG1522	sequence-specific DNA binding
NRE15_06750	COG4372	Transposase
NRE15_06765	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_06770	COG1876	peptidase activity
NRE15_06780	COG1132	(ABC) transporter
NRE15_06790	COG5002	protein histidine kinase activity
NRE15_06790	COG3850	Histidine kinase
NRE15_06810	COG1902	pentaerythritol trinitrate reductase activity
NRE15_06820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRE15_06835	COG0527	aspartate kinase activity
NRE15_06845	COG1082	Xylose isomerase domain protein TIM barrel
NRE15_06860	COG1794	racemase activity, acting on amino acids and derivatives
NRE15_06865	COG3118	belongs to the thioredoxin family
NRE15_06880	COG4946	Tricorn protease homolog
NRE15_06880	COG0823	Involved in the tonB-independent uptake of proteins
NRE15_06880	COG1506	peptidase
NRE15_06895	COG1070	Carbohydrate kinase
NRE15_06900	COG2115	Belongs to the xylose isomerase family
NRE15_06905	COG1940	carbohydrate kinase activity
NRE15_06910	COG3507	Belongs to the glycosyl hydrolase 43 family
NRE15_06925	COG0395	ABC-type sugar transport system, permease component
NRE15_06940	COG2207	Transcriptional regulator
NRE15_06945	COG0824	Thioesterase
NRE15_06955	COG0395	ABC-type sugar transport system, permease component
NRE15_06960	COG1175	transmembrane transport
NRE15_06975	COG0395	ABC-type sugar transport system, permease component
NRE15_06980	COG1175	transmembrane transport
NRE15_07005	COG3507	Belongs to the glycosyl hydrolase 43 family
NRE15_07020	COG0395	ABC-type sugar transport system, permease component
NRE15_07025	COG1175	transmembrane transport
NRE15_07040	COG3534	alpha-L-arabinofuranosidase
NRE15_07045	COG3940	Belongs to the glycosyl hydrolase 43 family
NRE15_07055	COG2160	L-arabinose isomerase activity
NRE15_07075	COG1609	Transcriptional regulator
NRE15_07080	COG0561	phosphatase activity
NRE15_07085	COG0561	phosphatase activity
NRE15_07090	COG2723	6-phospho-beta-galactosidase activity
NRE15_07095	COG2723	6-phospho-beta-galactosidase activity
NRE15_07100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_07100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_07105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_07110	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRE15_07120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRE15_07120	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NRE15_07125	COG1486	melibiose metabolic process
NRE15_07155	COG0789	Transcriptional regulator
NRE15_07170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRE15_07200	COG3976	FMN-binding domain protein
NRE15_07200	COG0431	NADPH-dependent FMN reductase
NRE15_07200	COG1053	succinate dehydrogenase
NRE15_07210	COG0842	Transport permease protein
NRE15_07215	COG1131	(ABC) transporter
NRE15_07220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRE15_07260	COG1482	cell wall glycoprotein biosynthetic process
NRE15_07265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_07265	COG3711	transcriptional antiterminator
NRE15_07270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRE15_07270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRE15_07270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_07280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRE15_07290	COG1363	Peptidase, m42
NRE15_07295	COG1496	oxidoreductase activity
NRE15_07300	COG2081	HI0933 family
NRE15_07305	COG3639	organic phosphonate transmembrane transporter activity
NRE15_07315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NRE15_07325	COG1388	LysM domain
NRE15_07325	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_07330	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_07330	COG1388	LysM domain
NRE15_07350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRE15_07370	COG0583	DNA-binding transcription factor activity
NRE15_07380	COG1737	Transcriptional regulator
NRE15_07390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NRE15_07395	COG3639	organic phosphonate transmembrane transporter activity
NRE15_07410	COG0028	Belongs to the TPP enzyme family
NRE15_07415	COG0656	L-ascorbic acid biosynthetic process
NRE15_07435	COG1131	(ABC) transporter
NRE15_07440	COG4585	Histidine kinase
NRE15_07445	COG2197	response regulator
NRE15_07455	COG1051	belongs to the nudix hydrolase family
NRE15_07460	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_07465	COG1388	LysM domain
NRE15_07470	COG2824	Alkylphosphonate utilization operon protein PhnA
NRE15_07480	COG0656	L-ascorbic acid biosynthetic process
NRE15_07500	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NRE15_07505	COG1518	maintenance of DNA repeat elements
NRE15_07535	COG1024	Enoyl-CoA hydratase
NRE15_07540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRE15_07545	COG0640	Transcriptional regulator
NRE15_07575	COG0702	epimerase
NRE15_07595	COG0582	viral genome integration into host DNA
NRE15_07600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRE15_07600	COG0519	Catalyzes the synthesis of GMP from XMP
NRE15_07625	COG1304	FMN binding
NRE15_07640	COG0438	transferase activity, transferring glycosyl groups
NRE15_07645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRE15_07650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NRE15_07665	COG0463	Glycosyl transferase, family 2
NRE15_07680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NRE15_07685	COG1177	transmembrane transport
NRE15_07690	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRE15_07695	COG3842	ATPase activity
NRE15_07700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRE15_07710	COG0802	atpase or kinase
NRE15_07720	COG0280	phosphate acetyltransferase
NRE15_07735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRE15_07740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRE15_07755	COG3682	Transcriptional regulator
NRE15_07780	COG0248	Ppx GppA phosphatase
NRE15_07785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRE15_07800	COG1473	amidohydrolase
NRE15_07820	COG0488	(ABC) transporter
NRE15_07825	COG0516	GMP reductase activity
NRE15_07830	COG0217	transcriptional regulatory protein
NRE15_07835	COG0386	Belongs to the glutathione peroxidase family
NRE15_07840	COG3620	sequence-specific DNA binding
NRE15_07840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRE15_07840	COG0617	tRNA 3'-terminal CCA addition
NRE15_07865	COG1609	Transcriptional regulator
NRE15_07870	COG2326	polyphosphate kinase activity
NRE15_07880	COG0101	tRNA pseudouridine synthase activity
NRE15_07890	COG1122	ATPase activity
NRE15_07895	COG1122	ATPase activity
NRE15_07900	COG0203	ribosomal protein L17
NRE15_07905	COG0202	RNA polymerase activity
NRE15_07910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRE15_07915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRE15_07920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRE15_07930	COG0563	adenylate kinase activity
NRE15_07940	COG0200	Binds to the 23S rRNA
NRE15_07945	COG1841	ribosomal large subunit assembly
NRE15_07950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRE15_07960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRE15_07965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRE15_07975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRE15_07985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRE15_07990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRE15_08005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRE15_08010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRE15_08020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRE15_08030	COG0088	Forms part of the polypeptide exit tunnel
NRE15_08035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRE15_08040	COG0051	transcription antitermination factor activity, RNA binding
NRE15_08055	COG0668	transmembrane transport
NRE15_08060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRE15_08065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRE15_08070	COG0049	tRNA binding
NRE15_08075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRE15_08085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRE15_08090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NRE15_08095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NRE15_08100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NRE15_08105	COG0037	tRNA processing
NRE15_08110	COG1098	S1 RNA binding domain
NRE15_08120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NRE15_08125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRE15_08130	COG0193	aminoacyl-tRNA hydrolase activity
NRE15_08135	COG0039	L-malate dehydrogenase activity
NRE15_08140	COG4466	Protein conserved in bacteria
NRE15_08145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRE15_08150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NRE15_08155	COG0084	hydrolase, TatD family'
NRE15_08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRE15_08165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRE15_08180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRE15_08185	COG0693	protein deglycase activity
NRE15_08190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRE15_08225	COG4608	Belongs to the ABC transporter superfamily
NRE15_08230	COG0444	Belongs to the ABC transporter superfamily
NRE15_08235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_08240	COG0601	transmembrane transport
NRE15_08245	COG4166	transmembrane transport
NRE15_08255	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRE15_08265	COG3850	Histidine kinase
NRE15_08265	COG5002	protein histidine kinase activity
NRE15_08270	COG0745	RESPONSE REGULATOR receiver
NRE15_08275	COG0629	single-stranded DNA binding
NRE15_08280	COG1481	regulation of sporulation
NRE15_08290	COG1660	Displays ATPase and GTPase activities
NRE15_08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRE15_08300	COG0492	ferredoxin-NADP+ reductase activity
NRE15_08305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRE15_08315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NRE15_08340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRE15_08345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NRE15_08350	COG0704	Plays a role in the regulation of phosphate uptake
NRE15_08355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRE15_08360	COG0581	inorganic phosphate transmembrane transporter activity
NRE15_08365	COG0573	inorganic phosphate transmembrane transporter activity
NRE15_08370	COG5002	protein histidine kinase activity
NRE15_08375	COG0745	RESPONSE REGULATOR receiver
NRE15_08380	COG2177	Part of the ABC transporter FtsEX involved in
NRE15_08385	COG2884	Cell division ATP-binding protein ftsE
NRE15_08395	COG0653	protein targeting
NRE15_08410	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NRE15_08420	COG1307	EDD domain protein, DegV family
NRE15_08425	COG1739	Uncharacterized protein family UPF0029
NRE15_08430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRE15_08435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRE15_08440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NRE15_08450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRE15_08455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRE15_08465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRE15_08490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRE15_08495	COG1121	(ABC) transporter
NRE15_08505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRE15_08510	COG2738	Putative neutral zinc metallopeptidase
NRE15_08520	COG4120	Belongs to the binding-protein-dependent transport system permease family
NRE15_08525	COG2984	ABC transporter substrate binding protein
NRE15_08550	COG0640	Transcriptional regulator
NRE15_08555	COG2217	Heavy metal translocating P-type atpase
NRE15_08575	COG1132	(ABC) transporter
NRE15_08600	COG2321	neutral zinc metallopeptidase
NRE15_08605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRE15_08620	COG0640	Transcriptional regulator
NRE15_08630	COG0546	phosphoglycolate phosphatase activity
NRE15_08640	COG1979	alcohol dehydrogenase
NRE15_08655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRE15_08670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRE15_08695	COG1268	BioY protein
NRE15_08700	COG1116	anion transmembrane transporter activity
NRE15_08705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NRE15_08730	COG2207	Transcriptional regulator
NRE15_08735	COG1132	(ABC) transporter
NRE15_08740	COG1132	(ABC) transporter
NRE15_08750	COG1131	(ABC) transporter
NRE15_08760	COG0747	negative chemotaxis
NRE15_08765	COG0601	transmembrane transport
NRE15_08770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_08775	COG0444	Belongs to the ABC transporter superfamily
NRE15_08790	COG1428	Deoxynucleoside kinase
NRE15_08825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRE15_08835	COG2813	Specifically methylates the guanine in position
NRE15_08840	COG1482	cell wall glycoprotein biosynthetic process
NRE15_08845	COG0561	phosphatase activity
NRE15_08850	COG0222	ribosome binding
NRE15_08855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRE15_08865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRE15_08880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NRE15_08885	COG3119	arylsulfatase activity
NRE15_08905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRE15_08910	COG2169	Transcriptional regulator
NRE15_08925	COG0366	Alpha amylase catalytic
NRE15_08935	COG0250	Participates in transcription elongation, termination and antitermination
NRE15_08940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRE15_08945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRE15_08950	COG1940	carbohydrate kinase activity
NRE15_08955	COG1595	DNA-templated transcription, initiation
NRE15_08960	COG3688	RNA-binding protein containing a PIN domain
NRE15_08965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRE15_08970	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NRE15_08980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRE15_08985	COG4956	integral membrane protein (PIN domain superfamily)
NRE15_08995	COG0756	dUTP diphosphatase activity
NRE15_09000	COG3842	ATPase activity
NRE15_09010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRE15_09020	COG0174	glutamine synthetase
NRE15_09025	COG0789	Transcriptional regulator
NRE15_09035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NRE15_09040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRE15_09045	COG0305	Participates in initiation and elongation during chromosome replication
NRE15_09050	COG0359	binds to the 23S rRNA
NRE15_09060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRE15_09065	COG0629	single-stranded DNA binding
NRE15_09075	COG0765	amino acid transport
NRE15_09080	COG0765	amino acid transport
NRE15_09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRE15_09095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NRE15_09100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NRE15_09115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NRE15_09120	COG2501	S4 domain
NRE15_09125	COG0592	DNA-directed DNA polymerase activity
NRE15_09130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NRE15_09135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NRE15_09140	COG0594	ribonuclease P activity
NRE15_09145	COG0706	membrane insertase activity
NRE15_09155	COG1263	PTS System
NRE15_09155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_09160	COG0366	Alpha amylase catalytic
NRE15_09175	COG2188	Transcriptional regulator
NRE15_09185	COG4535	Mg2 and Co2 transporter CorC
NRE15_09195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRE15_09200	COG1051	belongs to the nudix hydrolase family
NRE15_09205	COG0445	tRNA wobble uridine modification
NRE15_09210	COG3579	cysteine-type endopeptidase activity
NRE15_09225	COG1192	Involved in chromosome partitioning
NRE15_09230	COG1475	DNA binding
NRE15_09235	COG4481	Protein conserved in bacteria
NRE15_09240	COG0012	GTP binding
NRE15_09250	COG0516	GMP reductase activity
NRE15_09250	COG0517	IMP dehydrogenase activity
NRE15_09280	COG1827	regulation of RNA biosynthetic process
NRE15_09315	COG4297	protein containing double-stranded beta helix domain
NRE15_09320	COG0657	acetylesterase activity
NRE15_09320	COG2755	lipolytic protein G-D-S-L family
NRE15_09355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_09355	COG3711	transcriptional antiterminator
NRE15_09365	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRE15_09370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRE15_09375	COG2723	6-phospho-beta-galactosidase activity
NRE15_09380	COG1940	carbohydrate kinase activity
NRE15_09400	COG4463	regulation of RNA biosynthetic process
NRE15_09405	COG0542	response to heat
NRE15_09415	COG0583	DNA-binding transcription factor activity
NRE15_09420	COG1380	Effector of murein hydrolase LrgA
NRE15_09425	COG1346	cytolysis
NRE15_09430	COG1304	FMN binding
NRE15_09440	COG0590	tRNA wobble adenosine to inosine editing
NRE15_09455	COG1464	Belongs to the NlpA lipoprotein family
NRE15_09475	COG1573	uracil-dna glycosylase
NRE15_09480	COG3590	peptidase
NRE15_09485	COG1136	(ABC) transporter
NRE15_09495	COG0577	efflux transmembrane transporter activity
NRE15_09500	COG0745	RESPONSE REGULATOR receiver
NRE15_09510	COG0783	Belongs to the Dps family
NRE15_09515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NRE15_09520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRE15_09525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRE15_09530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRE15_09535	COG3870	Protein conserved in bacteria
NRE15_09550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRE15_09560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRE15_09575	COG0519	Catalyzes the synthesis of GMP from XMP
NRE15_09585	COG2723	6-phospho-beta-galactosidase activity
NRE15_09590	COG1609	Transcriptional regulator
NRE15_09595	COG1940	carbohydrate kinase activity
NRE15_09600	COG4209	transmembrane transport
NRE15_09605	COG0395	ABC-type sugar transport system, permease component
NRE15_09625	COG1970	mechanosensitive ion channel activity
NRE15_09630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRE15_09655	COG0778	Nitroreductase
NRE15_09665	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NRE15_09670	COG0436	Aminotransferase
NRE15_09680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRE15_09690	COG1132	(ABC) transporter
NRE15_09695	COG1132	(ABC) transporter
NRE15_09700	COG1078	dGTPase activity
NRE15_09705	COG0095	Lipoate-protein ligase
NRE15_09720	COG3343	RNA polymerase activity
NRE15_09725	COG0504	CTP synthase activity
NRE15_09745	COG0584	glycerophosphoryl diester phosphodiesterase
NRE15_09750	COG3842	ATPase activity
NRE15_09755	COG1175	transmembrane transport
NRE15_09785	COG2814	Major facilitator Superfamily
NRE15_09795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRE15_09800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NRE15_09805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRE15_09825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NRE15_09835	COG2851	Citrate transporter
NRE15_09845	COG0511	ligase activity, forming carbon-carbon bonds
NRE15_09850	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NRE15_09860	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NRE15_09865	COG3052	prosthetic group binding
NRE15_09890	COG0254	rRNA binding
NRE15_09895	COG2226	methyltransferase
NRE15_09900	COG0579	oxidoreductase
NRE15_09905	COG3613	nucleoside 2-deoxyribosyltransferase
NRE15_09915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRE15_09930	COG0494	nUDIX hydrolase
NRE15_09935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRE15_09940	COG1704	LemA family
NRE15_09950	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRE15_09955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRE15_09965	COG0736	holo-[acyl-carrier-protein] synthase activity
NRE15_09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRE15_09985	COG1253	flavin adenine dinucleotide binding
NRE15_09990	COG4122	O-methyltransferase activity
NRE15_10010	COG5002	protein histidine kinase activity
NRE15_10025	COG1136	(ABC) transporter
NRE15_10035	COG0745	RESPONSE REGULATOR receiver
NRE15_10040	COG2205	protein histidine kinase activity
NRE15_10050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NRE15_10055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRE15_10065	COG0569	domain protein
NRE15_10070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRE15_10075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRE15_10085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_10085	COG2190	(PTS) system
NRE15_10085	COG1263	PTS System
NRE15_10100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NRE15_10190	COG2003	Belongs to the UPF0758 family
NRE15_10220	COG2132	Multicopper oxidase
NRE15_10245	COG0657	acetylesterase activity
NRE15_10265	COG2217	Heavy metal translocating P-type atpase
NRE15_10270	COG2217	Heavy metal translocating P-type atpase
NRE15_10275	COG0563	adenylate kinase activity
NRE15_10300	COG0656	L-ascorbic acid biosynthetic process
NRE15_10305	COG0217	transcriptional regulatory protein
NRE15_10320	COG0004	ammonium transporteR
NRE15_10345	COG2188	Transcriptional regulator
NRE15_10350	COG1263	PTS System
NRE15_10350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_10350	COG2190	(PTS) system
NRE15_10355	COG2723	6-phospho-beta-galactosidase activity
NRE15_10360	COG1902	pentaerythritol trinitrate reductase activity
NRE15_10370	COG2267	carboxylic ester hydrolase activity
NRE15_10380	COG1349	DNA-binding transcription factor activity
NRE15_10385	COG1105	Belongs to the carbohydrate kinase PfkB family
NRE15_10390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRE15_10390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRE15_10390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRE15_10400	COG0633	Ferredoxin
NRE15_10400	COG0543	2 iron, 2 sulfur cluster binding
NRE15_10440	COG1063	alcohol dehydrogenase
NRE15_10450	COG1902	pentaerythritol trinitrate reductase activity
NRE15_10455	COG2723	6-phospho-beta-galactosidase activity
NRE15_10470	COG2096	Adenosyltransferase
NRE15_10500	COG4303	Ethanolamine ammonia lyase large subunit
NRE15_10505	COG4302	ethanolamine ammonia-lyase activity
NRE15_10510	COG4816	utilization protein
NRE15_10515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NRE15_10535	COG4869	propanediol catabolic process
NRE15_10545	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NRE15_10550	COG3192	ethanolamine utilization protein
NRE15_10555	COG1902	pentaerythritol trinitrate reductase activity
NRE15_10575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRE15_10580	COG1120	ATPase activity
NRE15_10585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRE15_10600	COG1492	cobalamin metabolic process
NRE15_10615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NRE15_10620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRE15_10625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NRE15_10630	COG0732	type I restriction modification DNA specificity domain
NRE15_10635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NRE15_10645	COG1609	Transcriptional regulator
NRE15_10650	COG3842	ATPase activity
NRE15_10660	COG4209	transmembrane transport
NRE15_10665	COG0395	ABC-type sugar transport system, permease component
NRE15_10680	COG1053	succinate dehydrogenase
NRE15_10680	COG3976	FMN-binding domain protein
NRE15_10685	COG1349	DNA-binding transcription factor activity
NRE15_10700	COG1178	ABC-type Fe3 transport system permease component
NRE15_10725	COG0747	negative chemotaxis
NRE15_10730	COG2508	Transcriptional regulator
NRE15_10730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NRE15_10735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRE15_10750	COG2329	Antibiotic biosynthesis monooxygenase
NRE15_10760	COG3842	ATPase activity
NRE15_10775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NRE15_10780	COG1234	tRNA 3'-trailer cleavage
NRE15_10800	COG1840	ABC-type Fe3 transport system, periplasmic component
NRE15_10810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRE15_10830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NRE15_10870	COG4946	Tricorn protease homolog
NRE15_10870	COG1506	peptidase
NRE15_10870	COG0823	Involved in the tonB-independent uptake of proteins
NRE15_10875	COG0747	negative chemotaxis
NRE15_10880	COG0601	transmembrane transport
NRE15_10885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_10890	COG0444	Belongs to the ABC transporter superfamily
NRE15_10895	COG4608	Belongs to the ABC transporter superfamily
NRE15_10920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NRE15_10930	COG0371	Dehydrogenase
NRE15_10940	COG3716	PTS system mannose fructose sorbose family IID component
NRE15_10960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRE15_10965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NRE15_10980	COG1960	acyl-CoA dehydrogenase activity
NRE15_10985	COG0583	DNA-binding transcription factor activity
NRE15_10990	COG0183	Belongs to the thiolase family
NRE15_11000	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRE15_11005	COG1024	Enoyl-CoA hydratase
NRE15_11010	COG0427	acetyl-CoA hydrolase
NRE15_11015	COG2610	gluconate transmembrane transporter activity
NRE15_11040	COG2376	Dihydroxyacetone kinase
NRE15_11045	COG2376	Dihydroxyacetone kinase
NRE15_11050	COG1461	Dihydroxyacetone kinase
NRE15_11055	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NRE15_11060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRE15_11065	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRE15_11090	COG1609	Transcriptional regulator
NRE15_11100	COG1131	(ABC) transporter
NRE15_11115	COG4211	Belongs to the binding-protein-dependent transport system permease family
NRE15_11125	COG1879	ABC-type sugar transport system periplasmic component
NRE15_11130	COG2207	Transcriptional regulator
NRE15_11130	COG4753	response regulator
NRE15_11135	COG2972	Histidine kinase
NRE15_11140	COG1879	ABC-type sugar transport system periplasmic component
NRE15_11145	COG4372	Transposase
NRE15_11160	COG0492	ferredoxin-NADP+ reductase activity
NRE15_11235	COG3842	ATPase activity
NRE15_11270	COG3842	ATPase activity
NRE15_11305	COG2364	Membrane
NRE15_11315	COG3842	ATPase activity
NRE15_11325	COG0395	ABC-type sugar transport system, permease component
NRE15_11330	COG4208	sulfate ABC transporter
NRE15_11335	COG3457	Alanine racemase
NRE15_11350	COG0583	DNA-binding transcription factor activity
NRE15_11365	COG0625	glutathione transferase activity
NRE15_11370	COG1785	Belongs to the alkaline phosphatase family
NRE15_11390	COG2608	mercury ion transmembrane transporter activity
NRE15_11410	COG3457	Alanine racemase
NRE15_11415	COG3804	dihydrodipicolinate reductase
NRE15_11425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRE15_11435	COG5012	cobalamin binding
NRE15_11445	COG0583	DNA-binding transcription factor activity
NRE15_11465	COG2096	Adenosyltransferase
NRE15_11485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRE15_11495	COG0747	negative chemotaxis
NRE15_11500	COG0601	transmembrane transport
NRE15_11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_11510	COG0444	Belongs to the ABC transporter superfamily
NRE15_11515	COG4608	Belongs to the ABC transporter superfamily
NRE15_11535	COG1940	carbohydrate kinase activity
NRE15_11540	COG1653	transport
NRE15_11545	COG1175	transmembrane transport
NRE15_11550	COG0395	ABC-type sugar transport system, permease component
NRE15_11555	COG1621	beta-fructofuranosidase activity
NRE15_11560	COG1940	carbohydrate kinase activity
NRE15_11565	COG3711	transcriptional antiterminator
NRE15_11585	COG4821	SIS domain
NRE15_11595	COG0494	nUDIX hydrolase
NRE15_11600	COG1802	Transcriptional regulator
NRE15_11605	COG2084	Dehydrogenase
NRE15_11620	COG1979	alcohol dehydrogenase
NRE15_11635	COG2390	Transcriptional regulator
NRE15_11655	COG1879	ABC-type sugar transport system periplasmic component
NRE15_11660	COG1830	Aldolase
NRE15_11690	COG2723	6-phospho-beta-galactosidase activity
NRE15_11695	COG1263	PTS System
NRE15_11695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_11695	COG2190	(PTS) system
NRE15_11740	COG3711	transcriptional antiterminator
NRE15_11745	COG1263	PTS System
NRE15_11745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_11745	COG2190	(PTS) system
NRE15_11750	COG2723	6-phospho-beta-galactosidase activity
NRE15_11785	COG1301	dicarboxylic acid transport
NRE15_11790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRE15_11795	COG4720	Psort location CytoplasmicMembrane, score
NRE15_11805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRE15_11815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRE15_11820	COG0285	dihydrofolate synthase activity
NRE15_11825	COG2116	formate transmembrane transporter activity
NRE15_11835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRE15_11840	COG0671	phosphoesterase, PA-phosphatase related
NRE15_11870	COG4129	membrane
NRE15_11875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NRE15_11910	COG0826	peptidase U32
NRE15_11930	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_11930	COG1388	LysM domain
NRE15_11935	COG1114	Component of the transport system for branched-chain amino acids
NRE15_11940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRE15_11945	COG0747	negative chemotaxis
NRE15_11955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_11960	COG0444	Belongs to the ABC transporter superfamily
NRE15_11965	COG4608	Belongs to the ABC transporter superfamily
NRE15_11980	COG1131	(ABC) transporter
NRE15_12015	COG2197	response regulator
NRE15_12025	COG1842	Phage shock protein A
NRE15_12030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NRE15_12040	COG4894	glucomannan catabolic process
NRE15_12050	COG0589	response to stress
NRE15_12055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRE15_12060	COG1607	acyl-coa hydrolase
NRE15_12065	COG2855	membrane
NRE15_12070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRE15_12075	COG1214	PFAM Peptidase M22, glycoprotease
NRE15_12085	COG0456	acetyltransferase
NRE15_12090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRE15_12105	COG0583	DNA-binding transcription factor activity
NRE15_12110	COG0183	Belongs to the thiolase family
NRE15_12115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NRE15_12125	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_12130	COG2610	gluconate transmembrane transporter activity
NRE15_12135	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRE15_12145	COG1269	ATP hydrolysis coupled proton transport
NRE15_12150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRE15_12160	COG1527	subunit (C
NRE15_12165	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
NRE15_12170	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NRE15_12180	COG1394	ATPase activity, coupled to movement of substances
NRE15_12190	COG1136	(ABC) transporter
NRE15_12195	COG0577	efflux transmembrane transporter activity
NRE15_12200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRE15_12220	COG0095	Lipoate-protein ligase
NRE15_12225	COG3250	beta-galactosidase activity
NRE15_12250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRE15_12260	COG0488	(ABC) transporter
NRE15_12275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRE15_12290	COG1316	TRANSCRIPTIONal
NRE15_12300	COG0789	Transcriptional regulator
NRE15_12320	COG1122	ATPase activity
NRE15_12325	COG4720	Psort location CytoplasmicMembrane, score
NRE15_12345	COG1388	LysM domain
NRE15_12345	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_12360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRE15_12375	COG0765	amino acid transport
NRE15_12380	COG1126	abc transporter atp-binding protein
NRE15_12390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRE15_12400	COG0110	maltose O-acetyltransferase activity
NRE15_12405	COG1803	Methylglyoxal synthase
NRE15_12460	COG4708	membrane
NRE15_12465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRE15_12480	COG4372	Transposase
NRE15_12485	COG1131	(ABC) transporter
NRE15_12500	COG1363	Peptidase, m42
NRE15_12505	COG1234	tRNA 3'-trailer cleavage
NRE15_12525	COG4166	transmembrane transport
NRE15_12530	COG0601	transmembrane transport
NRE15_12535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRE15_12540	COG0444	Belongs to the ABC transporter superfamily
NRE15_12545	COG4608	Belongs to the ABC transporter superfamily
NRE15_12550	COG2918	glutathione biosynthetic process
NRE15_12550	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRE15_12640	COG1653	transport
NRE15_12645	COG1175	transmembrane transport
NRE15_12650	COG0395	ABC-type sugar transport system, permease component
NRE15_12665	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NRE15_12685	COG1337	RAMP superfamily
NRE15_12690	COG1567	CRISPR-associated RAMP protein, Csm4 family
NRE15_12710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRE15_12715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRE15_12755	COG1473	amidohydrolase
NRE15_12760	COG1473	amidohydrolase
NRE15_12770	COG3842	ATPase activity
NRE15_12775	COG4209	transmembrane transport
NRE15_12785	COG0395	ABC-type sugar transport system, permease component
NRE15_12830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRE15_12835	COG1609	Transcriptional regulator
NRE15_12840	COG0517	IMP dehydrogenase activity
NRE15_12840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRE15_12845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRE15_12855	COG1129	ABC transporter
NRE15_12860	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRE15_12870	COG1653	transport
NRE15_12875	COG1175	transmembrane transport
NRE15_12910	COG3711	transcriptional antiterminator
NRE15_12915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_12915	COG2190	(PTS) system
NRE15_12915	COG1263	PTS System
NRE15_12920	COG2723	6-phospho-beta-galactosidase activity
NRE15_12935	COG3842	ATPase activity
NRE15_12940	COG1349	DNA-binding transcription factor activity
NRE15_12945	COG1175	transmembrane transport
NRE15_12950	COG0395	ABC-type sugar transport system, permease component
NRE15_12970	COG5002	protein histidine kinase activity
NRE15_12975	COG1136	(ABC) transporter
NRE15_12985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRE15_12990	COG1473	amidohydrolase
NRE15_12995	COG1288	antiporter activity
NRE15_13000	COG0251	oxidation-reduction process
NRE15_13035	COG3764	Sortase (surface protein transpeptidase)
NRE15_13040	COG0390	transport system, permease component
NRE15_13045	COG4619	ABC transporter
NRE15_13055	COG1175	transmembrane transport
NRE15_13060	COG0395	ABC-type sugar transport system, permease component
NRE15_13070	COG3344	reverse transcriptase
NRE15_13080	COG3583	domain protein
NRE15_13080	COG1621	beta-fructofuranosidase activity
NRE15_13080	COG5492	domain, Protein
NRE15_13090	COG0800	Aldolase
NRE15_13100	COG1312	Catalyzes the dehydration of D-mannonate
NRE15_13105	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_13125	COG5426	von Willebrand factor, type A
NRE15_13130	COG1940	carbohydrate kinase activity
NRE15_13145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRE15_13170	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRE15_13175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRE15_13180	COG0210	DNA helicase
NRE15_13185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRE15_13190	COG4851	CamS sex pheromone cAM373 precursor
NRE15_13195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NRE15_13205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NRE15_13215	COG0322	excinuclease ABC activity
NRE15_13225	COG1285	pathogenesis
NRE15_13235	COG2337	Toxic component of a toxin-antitoxin (TA) module
NRE15_13245	COG0673	inositol 2-dehydrogenase activity
NRE15_13255	COG0438	transferase activity, transferring glycosyl groups
NRE15_13260	COG1940	carbohydrate kinase activity
NRE15_13270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRE15_13285	COG0024	Methionine aminopeptidase
NRE15_13295	COG0438	transferase activity, transferring glycosyl groups
NRE15_13305	COG2309	aminopeptidase activity
NRE15_13310	COG0716	FMN binding
NRE15_13315	COG0534	Mate efflux family protein
NRE15_13320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRE15_13335	COG0438	transferase activity, transferring glycosyl groups
NRE15_13345	COG3307	-O-antigen
NRE15_13355	COG1215	transferase activity, transferring glycosyl groups
NRE15_13380	COG2137	regulation of response to DNA damage stimulus
NRE15_13390	COG1132	(ABC) transporter
NRE15_13395	COG1132	(ABC) transporter
NRE15_13400	COG1363	Peptidase, m42
NRE15_13415	COG2723	6-phospho-beta-galactosidase activity
NRE15_13420	COG2723	6-phospho-beta-galactosidase activity
NRE15_13425	COG2190	(PTS) system
NRE15_13425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_13425	COG1263	PTS System
NRE15_13435	COG1523	belongs to the glycosyl hydrolase 13 family
NRE15_13440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRE15_13445	COG2832	Protein of unknown function (DUF454)
NRE15_13450	COG1472	Belongs to the glycosyl hydrolase 3 family
NRE15_13455	COG1609	Transcriptional regulator
NRE15_13460	COG4209	transmembrane transport
NRE15_13465	COG0395	ABC-type sugar transport system, permease component
NRE15_13490	COG1131	(ABC) transporter
NRE15_13495	COG0842	Transport permease protein
NRE15_13500	COG4585	Histidine kinase
NRE15_13505	COG2197	response regulator
NRE15_13530	COG3842	ATPase activity
NRE15_13535	COG1178	ABC-type Fe3 transport system permease component
NRE15_13545	COG0483	inositol monophosphate 1-phosphatase activity
NRE15_13560	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRE15_13570	COG0656	L-ascorbic acid biosynthetic process
NRE15_13575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRE15_13580	COG0765	amino acid transport
NRE15_13585	COG1126	abc transporter atp-binding protein
NRE15_13590	COG0596	Alpha beta hydrolase
NRE15_13595	COG1671	Belongs to the UPF0178 family
NRE15_13600	COG2207	Transcriptional regulator
NRE15_13605	COG0673	inositol 2-dehydrogenase activity
NRE15_13625	COG0673	inositol 2-dehydrogenase activity
NRE15_13630	COG1028	Short-chain dehydrogenase reductase Sdr
NRE15_13635	COG0656	L-ascorbic acid biosynthetic process
NRE15_13645	COG3142	Participates in the control of copper homeostasis
NRE15_13650	COG2182	Extracellular solute-binding protein
NRE15_13655	COG1175	transmembrane transport
NRE15_13660	COG3833	ABC-type maltose transport systems, permease component
NRE15_13680	COG4372	Transposase
NRE15_13690	COG5521	maltodextrose utilization protein MalA
NRE15_13695	COG1609	Transcriptional regulator
NRE15_13710	COG1854	S-ribosylhomocysteine lyase activity
NRE15_13725	COG0058	SHG alpha-glucan phosphorylase activity
NRE15_13730	COG1640	4-alpha-glucanotransferase
NRE15_13735	COG1609	Transcriptional regulator
NRE15_13745	COG4545	Glutaredoxin-related protein
NRE15_13755	COG0295	cytidine deaminase activity
NRE15_13770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRE15_13775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRE15_13785	COG0058	SHG alpha-glucan phosphorylase activity
NRE15_13790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRE15_13800	COG0420	3'-5' exonuclease activity
NRE15_13805	COG4717	serine-type aminopeptidase activity
NRE15_13810	COG3481	metal-dependent phosphohydrolase, HD sub domain
NRE15_13830	COG0537	adenosine 5'-monophosphoramidase activity
NRE15_13840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRE15_13845	COG4939	FMN-binding domain protein
NRE15_13850	COG3344	reverse transcriptase
NRE15_13880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRE15_13885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NRE15_13890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRE15_13895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRE15_13905	COG1269	ATP hydrolysis coupled proton transport
NRE15_13915	COG4372	Transposase
NRE15_13920	COG1269	ATP hydrolysis coupled proton transport
NRE15_13925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRE15_13940	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
NRE15_13945	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NRE15_13950	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NRE15_13955	COG1394	ATPase activity, coupled to movement of substances
NRE15_13960	COG1968	undecaprenyl-diphosphatase activity
NRE15_13965	COG1263	PTS System
NRE15_13965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRE15_13965	COG2190	(PTS) system
NRE15_13970	COG2706	6-phosphogluconolactonase activity
NRE15_13975	COG0628	permease
NRE15_13985	COG1811	Na channel or pump
NRE15_13990	COG3442	glutamine amidotransferase
NRE15_13995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRE15_14005	COG1435	thymidine kinase activity
NRE15_14010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRE15_14015	COG2890	protein-(glutamine-N5) methyltransferase activity
NRE15_14020	COG0009	L-threonylcarbamoyladenylate synthase
NRE15_14025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRE15_14030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRE15_14040	COG3425	synthase
NRE15_14050	COG1393	Belongs to the ArsC family
NRE15_14055	COG0356	it plays a direct role in the translocation of protons across the membrane
NRE15_14065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRE15_14075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRE15_14080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRE15_14085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRE15_14105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRE15_14125	COG2001	Belongs to the MraZ family
NRE15_14130	COG0275	rRNA processing
NRE15_14140	COG0768	penicillin binding
NRE15_14155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRE15_14185	COG2302	S4 RNA-binding domain
NRE15_14190	COG3599	regulation of cell shape
NRE15_14195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRE15_14205	COG3853	Toxic anion resistance protein (TelA)
NRE15_14215	COG0494	nUDIX hydrolase
NRE15_14225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRE15_14235	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NRE15_14240	COG1104	cysteine desulfurase activity
NRE15_14250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NRE15_14260	COG0525	valine-tRNA ligase activity
NRE15_14265	COG0285	dihydrofolate synthase activity
NRE15_14270	COG2003	Belongs to the UPF0758 family
NRE15_14275	COG1278	Cold shock
NRE15_14285	COG1077	Cell shape determining protein MreB Mrl
NRE15_14310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRE15_14315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRE15_14320	COG3279	Response regulator of the LytR AlgR family
NRE15_14325	COG1597	lipid kinase activity
NRE15_14330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRE15_14335	COG4472	Bacterial protein of unknown function (DUF965)
NRE15_14340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRE15_14345	COG3906	Belongs to the UPF0473 family
NRE15_14350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRE15_14355	COG0572	uridine kinase
NRE15_14360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRE15_14375	COG2197	response regulator
NRE15_14380	COG4841	protein insertion into membrane
NRE15_14385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRE15_14390	COG0019	diaminopimelate decarboxylase activity
NRE15_14395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRE15_14410	COG1164	Oligoendopeptidase f
NRE15_14420	COG0583	DNA-binding transcription factor activity
NRE15_14425	COG1757	Na H antiporter
NRE15_14430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRE15_14435	COG1473	amidohydrolase
NRE15_14450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRE15_14460	COG1295	ribonuclease BN
NRE15_14465	COG0772	Belongs to the SEDS family
NRE15_14470	COG0509	glycine decarboxylation via glycine cleavage system
NRE15_14475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRE15_14480	COG1466	dna polymerase III delta subunit
NRE15_14485	COG0268	Binds directly to 16S ribosomal RNA
NRE15_14490	COG0556	nucleotide-excision repair
NRE15_14500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRE15_14505	COG1185	polyribonucleotide nucleotidyltransferase activity
NRE15_14530	COG1316	TRANSCRIPTIONal
NRE15_14535	COG0194	GDP metabolic process
NRE15_14545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRE15_14550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRE15_14555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRE15_14555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRE15_14560	COG0631	protein serine/threonine phosphatase activity
NRE15_14565	COG0515	serine threonine protein kinase
NRE15_14565	COG2815	serine threonine protein kinase
NRE15_14570	COG1162	GTPase activity
NRE15_14575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRE15_14580	COG1564	THIamine pyrophosphokinase
NRE15_14590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRE15_14595	COG1302	Protein conserved in bacteria
NRE15_14600	COG1461	Dihydroxyacetone kinase