locus-tag	class	description
CL176_00005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CL176_00010	COG2501	S4 domain
CL176_00015	COG0592	DNA-directed DNA polymerase activity
CL176_00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CL176_00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CL176_00055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CL176_00060	COG1051	belongs to the nudix hydrolase family
CL176_00065	COG0445	tRNA wobble uridine modification
CL176_00075	COG1802	Transcriptional regulator
CL176_00090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CL176_00095	COG0357	Ribosomal RNA small subunit methyltransferase G
CL176_00100	COG1192	Involved in chromosome partitioning
CL176_00105	COG1475	DNA binding
CL176_00110	COG4481	Protein conserved in bacteria
CL176_00115	COG0012	GTP binding
CL176_00135	COG5002	protein histidine kinase activity
CL176_00145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CL176_00160	COG4708	membrane
CL176_00190	COG0542	response to heat
CL176_00200	COG0590	tRNA wobble adenosine to inosine editing
CL176_00225	COG3590	peptidase
CL176_00230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CL176_00235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CL176_00240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CL176_00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CL176_00250	COG3870	Protein conserved in bacteria
CL176_00265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CL176_00270	COG2827	Endonuclease containing a URI domain
CL176_00275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CL176_00285	COG2818	Glycosylase
CL176_00295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CL176_00300	COG1714	RDD family
CL176_00305	COG0616	signal peptide processing
CL176_00310	COG0039	L-malate dehydrogenase activity
CL176_00315	COG0436	Aminotransferase
CL176_00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CL176_00325	COG2011	ABC-type metal ion transport system permease component
CL176_00330	COG1785	Belongs to the alkaline phosphatase family
CL176_00345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CL176_00350	COG1464	Belongs to the NlpA lipoprotein family
CL176_00355	COG1464	Belongs to the NlpA lipoprotein family
CL176_00360	COG1078	dGTPase activity
CL176_00365	COG0095	Lipoate-protein ligase
CL176_00390	COG1175	transmembrane transport
CL176_00395	COG3833	ABC-type maltose transport systems, permease component
CL176_00400	COG3842	ATPase activity
CL176_00405	COG0584	glycerophosphoryl diester phosphodiesterase
CL176_00435	COG1136	(ABC) transporter
CL176_00440	COG1653	transport
CL176_00455	COG1175	transmembrane transport
CL176_00460	COG0395	ABC-type sugar transport system, permease component
CL176_00465	COG3842	ATPase activity
CL176_00470	COG1653	transport
CL176_00475	COG0191	fructose-bisphosphate aldolase activity
CL176_00480	COG1882	Formate acetyltransferase
CL176_00485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CL176_00490	COG0626	cystathionine gamma-synthase activity
CL176_00495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CL176_00505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CL176_00510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CL176_00515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CL176_00540	COG1428	Deoxynucleoside kinase
CL176_00545	COG4175	Glycine betaine
CL176_00545	COG3448	diguanylate cyclase activity
CL176_00560	COG1053	succinate dehydrogenase
CL176_00575	COG1063	alcohol dehydrogenase
CL176_00580	COG0436	Aminotransferase
CL176_00585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CL176_00610	COG1611	Belongs to the LOG family
CL176_00620	COG1704	LemA family
CL176_00630	COG1181	Belongs to the D-alanine--D-alanine ligase family
CL176_00635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CL176_00645	COG0736	holo-[acyl-carrier-protein] synthase activity
CL176_00665	COG1253	flavin adenine dinucleotide binding
CL176_00675	COG0561	phosphatase activity
CL176_00685	COG0745	RESPONSE REGULATOR receiver
CL176_00690	COG5002	protein histidine kinase activity
CL176_00710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CL176_00715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CL176_00725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CL176_00730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CL176_00735	COG0625	glutathione transferase activity
CL176_00760	COG1473	amidohydrolase
CL176_00775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CL176_00780	COG1607	acyl-coa hydrolase
CL176_00785	COG1214	PFAM Peptidase M22, glycoprotease
CL176_00805	COG0488	(ABC) transporter
CL176_00810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CL176_00815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CL176_00820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CL176_00850	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CL176_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CL176_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CL176_00940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CL176_00950	COG4464	protein tyrosine phosphatase activity
CL176_00955	COG1316	TRANSCRIPTIONal
CL176_00975	COG1335	isochorismatase
CL176_00985	COG1737	Transcriptional regulator
CL176_00995	COG0561	phosphatase activity
CL176_01005	COG1131	(ABC) transporter
CL176_01100	COG1363	Peptidase, m42
CL176_01105	COG0095	Lipoate-protein ligase
CL176_01110	COG0791	NLP P60 protein
CL176_01110	COG1388	LysM domain
CL176_01115	COG2918	glutathione biosynthetic process
CL176_01115	COG1181	Belongs to the D-alanine--D-alanine ligase family
CL176_01210	COG0582	viral genome integration into host DNA
CL176_01220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CL176_01235	COG0708	Exodeoxyribonuclease III
CL176_01260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CL176_01260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CL176_01265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CL176_01270	COG2217	Heavy metal translocating P-type atpase
CL176_01280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CL176_01290	COG3290	protein histidine kinase activity
CL176_01305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CL176_01335	COG4876	unkown
CL176_01340	COG1053	succinate dehydrogenase
CL176_01340	COG3976	FMN-binding domain protein
CL176_01395	COG2826	transposase and inactivated derivatives, IS30 family
CL176_01415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CL176_01420	COG0346	lactoylglutathione lyase activity
CL176_01425	COG3275	phosphorelay sensor kinase activity
CL176_01430	COG3279	Response regulator of the LytR AlgR family
CL176_01440	COG1346	cytolysis
CL176_01460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CL176_01495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CL176_01510	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_01520	COG0210	DNA helicase
CL176_01525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CL176_01530	COG4851	CamS sex pheromone cAM373 precursor
CL176_01535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CL176_01545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CL176_01555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CL176_01560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CL176_01565	COG0138	bifunctional purine biosynthesis protein purh
CL176_01570	COG0151	Belongs to the GarS family
CL176_01575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CL176_01580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CL176_01590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CL176_01600	COG0549	Belongs to the carbamate kinase family
CL176_01605	COG0519	Catalyzes the synthesis of GMP from XMP
CL176_01605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CL176_01635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CL176_01640	COG2261	transglycosylase associated protein
CL176_01650	COG0024	Methionine aminopeptidase
CL176_01660	COG0438	transferase activity, transferring glycosyl groups
CL176_01670	COG2309	aminopeptidase activity
CL176_01675	COG0716	FMN binding
CL176_01680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CL176_01695	COG0438	transferase activity, transferring glycosyl groups
CL176_01715	COG1215	transferase activity, transferring glycosyl groups
CL176_01720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CL176_01755	COG1132	(ABC) transporter
CL176_01770	COG1523	belongs to the glycosyl hydrolase 13 family
CL176_01780	COG4166	transmembrane transport
CL176_01785	COG0601	transmembrane transport
CL176_01790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CL176_01795	COG0444	Belongs to the ABC transporter superfamily
CL176_01800	COG4608	Belongs to the ABC transporter superfamily
CL176_01805	COG1363	Peptidase, m42
CL176_01810	COG4166	transmembrane transport
CL176_01850	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CL176_01855	COG1288	antiporter activity
CL176_01860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CL176_01865	COG2376	Dihydroxyacetone kinase
CL176_01870	COG1461	Dihydroxyacetone kinase
CL176_01875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CL176_01880	COG1464	Belongs to the NlpA lipoprotein family
CL176_01890	COG3037	sugar-specific permease SgaT UlaA
CL176_01900	COG1349	DNA-binding transcription factor activity
CL176_01920	COG1028	Short-chain dehydrogenase reductase Sdr
CL176_01925	COG3250	beta-galactosidase activity
CL176_01930	COG1609	Transcriptional regulator
CL176_01935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL176_01945	COG1312	Catalyzes the dehydration of D-mannonate
CL176_01950	COG0800	Aldolase
CL176_01960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CL176_01975	COG3716	PTS system mannose fructose sorbose family IID component
CL176_01985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CL176_01995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CL176_02015	COG0698	ribose 5-phosphate isomerase
CL176_02025	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_02100	COG0052	Belongs to the universal ribosomal protein uS2 family
CL176_02135	COG1783	phage Terminase large subunit
CL176_02160	COG0629	single-stranded DNA binding
CL176_02185	COG3723	Recombinational DNA repair protein, rece pathway
CL176_02195	COG5377	YqaJ viral recombinase family
CL176_02285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL176_02290	COG1869	D-ribose catabolic process
CL176_02295	COG1129	ABC transporter
CL176_02300	COG1172	Belongs to the binding-protein-dependent transport system permease family
CL176_02305	COG1879	ABC-type sugar transport system periplasmic component
CL176_02320	COG1070	Carbohydrate kinase
CL176_02325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_02325	COG1263	PTS System
CL176_02355	COG3344	reverse transcriptase
CL176_02365	COG3711	transcriptional antiterminator
CL176_02365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_02375	COG3730	PTS system glucitol sorbitol-specific
CL176_02380	COG3732	PTS system glucitol sorbitol-specific
CL176_02395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CL176_02410	COG1349	DNA-binding transcription factor activity
CL176_02455	COG3414	Phosphotransferase system galactitol-specific IIB component
CL176_02460	COG3775	system Galactitol-specific IIC component
CL176_02465	COG1063	alcohol dehydrogenase
CL176_02470	COG3684	Belongs to the aldolase LacD family
CL176_02480	COG0561	phosphatase activity
CL176_02500	COG1484	DNA-dependent DNA replication
CL176_02510	COG2801	Transposase and inactivated derivatives
CL176_02520	COG1053	succinate dehydrogenase
CL176_02525	COG1053	succinate dehydrogenase
CL176_02525	COG3976	FMN-binding domain protein
CL176_02525	COG0431	NADPH-dependent FMN reductase
CL176_02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_02540	COG3711	transcriptional antiterminator
CL176_02575	COG2190	(PTS) system
CL176_02575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_02575	COG1263	PTS System
CL176_02605	COG3711	transcriptional antiterminator
CL176_02605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_02610	COG2706	6-phosphogluconolactonase activity
CL176_02625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CL176_02645	COG0561	phosphatase activity
CL176_02660	COG1454	alcohol dehydrogenase
CL176_02665	COG1349	DNA-binding transcription factor activity
CL176_02670	COG0673	inositol 2-dehydrogenase activity
CL176_02675	COG1082	Xylose isomerase domain protein TIM barrel
CL176_02680	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CL176_02685	COG0673	inositol 2-dehydrogenase activity
CL176_02695	COG1447	Phosphotransferase system cellobiose-specific component IIA
CL176_02705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL176_02710	COG3962	Belongs to the TPP enzyme family
CL176_02715	COG0191	fructose-bisphosphate aldolase activity
CL176_02720	COG1012	belongs to the aldehyde dehydrogenase family
CL176_02730	COG1269	ATP hydrolysis coupled proton transport
CL176_02735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CL176_02745	COG1527	subunit (C
CL176_02750	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CL176_02760	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CL176_02765	COG1394	ATPase activity, coupled to movement of substances
CL176_02790	COG1942	4-Oxalocrotonate Tautomerase
CL176_02815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CL176_02820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CL176_02835	COG3257	ureidoglycine aminohydrolase activity
CL176_02840	COG2508	Transcriptional regulator
CL176_02845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CL176_02850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL176_02855	COG1953	Uracil, thiamine, allantoin
CL176_02860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CL176_02875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CL176_02890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CL176_02910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CL176_02915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CL176_02925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CL176_02935	COG3443	Belongs to the bacterial solute-binding protein 9 family
CL176_02940	COG0803	Belongs to the bacterial solute-binding protein 9 family
CL176_02940	COG3443	Belongs to the bacterial solute-binding protein 9 family
CL176_02950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CL176_02955	COG0471	metal ion transport
CL176_02960	COG0662	Cupin 2, conserved barrel domain protein
CL176_02965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CL176_02970	COG0372	Belongs to the citrate synthase family
CL176_02975	COG0473	3-isopropylmalate dehydrogenase activity
CL176_02985	COG1120	ATPase activity
CL176_02990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CL176_03000	COG2801	Transposase and inactivated derivatives
CL176_03015	COG2801	Transposase and inactivated derivatives
CL176_03030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CL176_03035	COG1473	amidohydrolase
CL176_03045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CL176_03050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CL176_03050	COG3976	FMN-binding domain protein
CL176_03055	COG0543	2 iron, 2 sulfur cluster binding
CL176_03055	COG0633	Ferredoxin
CL176_03065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CL176_03085	COG1129	ABC transporter
CL176_03090	COG0435	Glutathione S-transferase
CL176_03095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CL176_03105	COG1073	alpha beta
CL176_03110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CL176_03145	COG4129	membrane
CL176_03155	COG0180	Tryptophanyl-tRNA synthetase
CL176_03160	COG1393	Belongs to the ArsC family
CL176_03165	COG4862	establishment of competence for transformation
CL176_03175	COG1164	Oligoendopeptidase f
CL176_03180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CL176_03195	COG1363	Peptidase, m42
CL176_03200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL176_03210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CL176_03220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CL176_03225	COG0237	dephospho-CoA kinase activity
CL176_03230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CL176_03240	COG1484	DNA-dependent DNA replication
CL176_03245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CL176_03260	COG1573	uracil-dna glycosylase
CL176_03265	COG0778	Nitroreductase
CL176_03275	COG1132	(ABC) transporter
CL176_03280	COG1132	(ABC) transporter
CL176_03285	COG2826	transposase and inactivated derivatives, IS30 family
CL176_03295	COG1121	(ABC) transporter
CL176_03300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CL176_03305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CL176_03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
CL176_03325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CL176_03335	COG0438	transferase activity, transferring glycosyl groups
CL176_03345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CL176_03350	COG0564	pseudouridine synthase activity
CL176_03355	COG2239	Acts as a magnesium transporter
CL176_03360	COG2153	protein acetylation
CL176_03385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_03400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CL176_03405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CL176_03410	COG1534	Rna-binding protein
CL176_03415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CL176_03420	COG1713	HD superfamily hydrolase involved in NAD metabolism
CL176_03425	COG0799	negative regulation of ribosome biogenesis
CL176_03430	COG2226	methyltransferase
CL176_03435	COG1323	Belongs to the UPF0348 family
CL176_03450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CL176_03460	COG0740	serine-type endopeptidase activity
CL176_03465	COG2390	Transcriptional regulator
CL176_03470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CL176_03475	COG0126	phosphoglycerate kinase activity
CL176_03480	COG0149	triose-phosphate isomerase activity
CL176_03485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CL176_03490	COG0148	phosphopyruvate hydratase activity
CL176_03495	COG0028	Belongs to the TPP enzyme family
CL176_03500	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_03500	COG1388	LysM domain
CL176_03510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CL176_03520	COG0557	exoribonuclease II activity
CL176_03535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CL176_03545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CL176_03550	COG1459	type II secretion system
CL176_03575	COG0006	proline dipeptidase activity
CL176_03585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CL176_03595	COG1570	exodeoxyribonuclease VII activity
CL176_03600	COG1722	exodeoxyribonuclease VII activity
CL176_03610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CL176_03615	COG0497	DNA recombination
CL176_03620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CL176_03630	COG0242	peptide deformylase activity
CL176_03640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CL176_03655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CL176_03675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CL176_03680	COG0511	ligase activity, forming carbon-carbon bonds
CL176_03685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CL176_03690	COG0439	Biotin carboxylase
CL176_03695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CL176_03700	COG0825	malonyl-CoA metabolic process
CL176_03725	COG0356	it plays a direct role in the translocation of protons across the membrane
CL176_03730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CL176_03745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CL176_03755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CL176_03760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CL176_03770	COG4476	Belongs to the UPF0223 family
CL176_03775	COG0483	inositol monophosphate 1-phosphatase activity
CL176_03785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CL176_03795	COG0772	Belongs to the SEDS family
CL176_03800	COG4471	UPF0298 protein
CL176_03805	COG0742	ribosomal rna small subunit methyltransferase
CL176_03810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CL176_03815	COG1555	photosystem II stabilization
CL176_03835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CL176_03840	COG0765	amino acid transport
CL176_03845	COG0765	amino acid transport
CL176_03850	COG2190	(PTS) system
CL176_03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_03850	COG1263	PTS System
CL176_03855	COG1846	Transcriptional regulator
CL176_03860	COG0346	lactoylglutathione lyase activity
CL176_03865	COG0346	lactoylglutathione lyase activity
CL176_03870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CL176_03885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CL176_03890	COG1780	Probably involved in ribonucleotide reductase function
CL176_03935	COG0737	Belongs to the 5'-nucleotidase family
CL176_03940	COG4470	Protein conserved in bacteria
CL176_03945	COG0647	UMP catabolic process
CL176_03955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CL176_03960	COG0492	ferredoxin-NADP+ reductase activity
CL176_03965	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CL176_03970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CL176_03975	COG1185	polyribonucleotide nucleotidyltransferase activity
CL176_03980	COG0166	Belongs to the GPI family
CL176_04100	COG0018	arginyl-trna synthetase
CL176_04240	COG1191	sigma factor activity
CL176_04275	COG3711	transcriptional antiterminator
CL176_04295	COG4372	Transposase
CL176_04315	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CL176_04320	COG1388	LysM domain
CL176_04320	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_04325	COG0495	leucyl-tRNA aminoacylation
CL176_04330	COG2244	polysaccharide biosynthetic process
CL176_04335	COG1187	pseudouridine synthase activity
CL176_04375	COG0489	protein tyrosine kinase activity
CL176_04380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CL176_04390	COG0438	transferase activity, transferring glycosyl groups
CL176_04395	COG0463	Glycosyl transferase, family 2
CL176_04395	COG1216	Glycosyl transferase, family 2
CL176_04405	COG0438	transferase activity, transferring glycosyl groups
CL176_04410	COG1216	Glycosyl transferase, family 2
CL176_04435	COG1216	Glycosyl transferase, family 2
CL176_04465	COG1857	crispr-associated protein
CL176_04480	COG1518	maintenance of DNA repeat elements
CL176_04510	COG2801	Transposase and inactivated derivatives
CL176_04520	COG4166	transmembrane transport
CL176_04525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CL176_04530	COG2032	superoxide dismutase activity
CL176_04545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CL176_04550	COG1177	transmembrane transport
CL176_04555	COG1176	ABC-type spermidine putrescine transport system, permease component I
CL176_04560	COG3842	ATPase activity
CL176_04575	COG0346	lactoylglutathione lyase activity
CL176_04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL176_04590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CL176_04605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL176_04605	COG0072	phenylalanine-tRNA ligase activity
CL176_04630	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CL176_04645	COG3711	transcriptional antiterminator
CL176_04650	COG1193	negative regulation of DNA recombination
CL176_04655	COG3118	belongs to the thioredoxin family
CL176_04660	COG0686	Belongs to the AlaDH PNT family
CL176_04700	COG0668	transmembrane transport
CL176_04715	COG1609	Transcriptional regulator
CL176_04725	COG0525	valine-tRNA ligase activity
CL176_04730	COG2003	Belongs to the UPF0758 family
CL176_04735	COG1278	Cold shock
CL176_04745	COG3022	response to hydroperoxide
CL176_04755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CL176_04765	COG4619	ABC transporter
CL176_04770	COG0390	transport system, permease component
CL176_04775	COG3590	peptidase
CL176_04790	COG3590	peptidase
CL176_04800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_04800	COG2190	(PTS) system
CL176_04800	COG1263	PTS System
CL176_04815	COG1077	Cell shape determining protein MreB Mrl
CL176_04820	COG1792	Involved in formation and maintenance of cell shape
CL176_04830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CL176_04840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CL176_04855	COG1053	succinate dehydrogenase
CL176_04855	COG0431	NADPH-dependent FMN reductase
CL176_04855	COG3976	FMN-binding domain protein
CL176_04865	COG1842	Phage shock protein A
CL176_04885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CL176_04900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CL176_04910	COG1263	PTS System
CL176_04910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_04915	COG0366	Alpha amylase catalytic
CL176_04920	COG0542	response to heat
CL176_04925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CL176_04930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CL176_04935	COG0022	dehydrogenase e1 component
CL176_04940	COG0508	dehydrogenase complex catalyzes the overall conversion of
CL176_04945	COG3344	reverse transcriptase
CL176_04955	COG3583	domain protein
CL176_04965	COG0726	polysaccharide deacetylase
CL176_04970	COG0571	ribonuclease III activity
CL176_04975	COG1196	nuclear chromosome segregation
CL176_04980	COG0561	phosphatase activity
CL176_04985	COG0552	protein localization to endoplasmic reticulum
CL176_04990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CL176_04995	COG1302	Protein conserved in bacteria
CL176_05000	COG1461	Dihydroxyacetone kinase
CL176_05005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CL176_05010	COG0416	fatty acid biosynthetic process
CL176_05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CL176_05020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CL176_05035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CL176_05040	COG1104	cysteine desulfurase activity
CL176_05050	COG0482	sulfurtransferase activity
CL176_05060	COG0719	Fe-S assembly protein
CL176_05065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CL176_05070	COG0822	iron-sulfur transferase activity
CL176_05075	COG0719	Fe-S assembly protein
CL176_05085	COG0604	alcohol dehydrogenase
CL176_05100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CL176_05105	COG1597	lipid kinase activity
CL176_05120	COG1732	Glycine betaine
CL176_05140	COG0561	phosphatase activity
CL176_05145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CL176_05155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CL176_05165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CL176_05175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CL176_05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CL176_05190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CL176_05195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CL176_05215	COG2197	response regulator
CL176_05220	COG4841	protein insertion into membrane
CL176_05225	COG0628	permease
CL176_05235	COG0693	protein deglycase activity
CL176_05240	COG1803	Methylglyoxal synthase
CL176_05245	COG0542	response to heat
CL176_05250	COG3344	reverse transcriptase
CL176_05255	COG3344	reverse transcriptase
CL176_05275	COG0628	permease
CL176_05280	COG1030	water channel activity
CL176_05285	COG4864	UPF0365 protein
CL176_05305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CL176_05310	COG0528	UMP kinase activity
CL176_05315	COG0233	cytoplasmic translational termination
CL176_05320	COG1053	succinate dehydrogenase
CL176_05320	COG3976	FMN-binding domain protein
CL176_05335	COG4589	Belongs to the CDS family
CL176_05340	COG0750	zinc metalloprotease
CL176_05345	COG2176	DNA-directed DNA polymerase activity
CL176_05350	COG0431	NADPH-dependent FMN reductase
CL176_05355	COG0779	Required for maturation of 30S ribosomal subunits
CL176_05360	COG0195	Participates in both transcription termination and antitermination
CL176_05365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CL176_05380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CL176_05385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CL176_05390	COG0196	riboflavin kinase activity
CL176_05400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CL176_05405	COG0443	Heat shock 70 kDa protein
CL176_05410	COG0484	heat shock protein binding
CL176_05415	COG0481	GTPase activity
CL176_05420	COG2610	gluconate transmembrane transporter activity
CL176_05425	COG0783	Belongs to the Dps family
CL176_05430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CL176_05455	COG0402	S-adenosylhomocysteine deaminase activity
CL176_05460	COG1012	belongs to the aldehyde dehydrogenase family
CL176_05470	COG1388	LysM domain
CL176_05515	COG1725	Transcriptional regulator
CL176_05585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CL176_05625	COG3620	sequence-specific DNA binding
CL176_05660	COG2003	Belongs to the UPF0758 family
CL176_05665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CL176_05730	COG3064	Membrane
CL176_05730	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CL176_05760	COG1475	DNA binding
CL176_05765	COG1192	Involved in chromosome partitioning
CL176_05795	COG1263	PTS System
CL176_05795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_05795	COG2190	(PTS) system
CL176_05800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CL176_05815	COG1012	belongs to the aldehyde dehydrogenase family
CL176_05815	COG1454	alcohol dehydrogenase
CL176_05825	COG0860	N-Acetylmuramoyl-L-alanine amidase
CL176_05830	COG1388	LysM domain
CL176_05830	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_05835	COG4942	peptidase
CL176_05845	COG2824	Alkylphosphonate utilization operon protein PhnA
CL176_05850	COG0765	amino acid transport
CL176_05870	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CL176_05900	COG4120	Belongs to the binding-protein-dependent transport system permease family
CL176_05915	COG1227	inorganic diphosphatase activity
CL176_05920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CL176_05925	COG0187	DNA topoisomerase II activity
CL176_05930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CL176_05940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CL176_05945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CL176_05950	COG4974	Belongs to the 'phage' integrase family
CL176_05955	COG0446	pyridine nucleotide-disulphide oxidoreductase
CL176_05960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CL176_05965	COG0758	DNA mediated transformation
CL176_05975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CL176_05980	COG0681	Belongs to the peptidase S26 family
CL176_05985	COG0793	Belongs to the peptidase S41A family
CL176_05985	COG3409	Peptidoglycan-binding domain 1 protein
CL176_05990	COG4479	Belongs to the UPF0346 family
CL176_05995	COG1272	protein, Hemolysin III
CL176_06000	COG0671	phosphoesterase, PA-phosphatase related
CL176_06010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CL176_06015	COG0488	(ABC) transporter
CL176_06020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CL176_06025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CL176_06045	COG1564	THIamine pyrophosphokinase
CL176_06050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CL176_06055	COG1162	GTPase activity
CL176_06060	COG2815	serine threonine protein kinase
CL176_06060	COG0515	serine threonine protein kinase
CL176_06065	COG0631	protein serine/threonine phosphatase activity
CL176_06070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL176_06070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CL176_06075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CL176_06080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CL176_06085	COG1758	RNA polymerase activity
CL176_06090	COG0194	GDP metabolic process
CL176_06095	COG1394	ATPase activity, coupled to movement of substances
CL176_06100	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CL176_06105	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CL176_06110	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CL176_06115	COG1527	subunit (C
CL176_06125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CL176_06130	COG1269	ATP hydrolysis coupled proton transport
CL176_06240	COG1185	polyribonucleotide nucleotidyltransferase activity
CL176_06250	COG0577	efflux transmembrane transporter activity
CL176_06255	COG0577	efflux transmembrane transporter activity
CL176_06255	COG1136	(ABC) transporter
CL176_06275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CL176_06280	COG2755	lipolytic protein G-D-S-L family
CL176_06280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CL176_06285	COG0556	nucleotide-excision repair
CL176_06290	COG0268	Binds directly to 16S ribosomal RNA
CL176_06300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CL176_06310	COG0772	Belongs to the SEDS family
CL176_06315	COG1295	ribonuclease BN
CL176_06330	COG1914	H( )-stimulated, divalent metal cation uptake system
CL176_06335	COG0010	Belongs to the arginase family
CL176_06345	COG0596	Alpha beta hydrolase
CL176_06350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CL176_06355	COG1126	abc transporter atp-binding protein
CL176_06375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CL176_06390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CL176_06395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CL176_06400	COG0019	diaminopimelate decarboxylase activity
CL176_06410	COG0431	NADPH-dependent FMN reductase
CL176_06410	COG1053	succinate dehydrogenase
CL176_06410	COG3976	FMN-binding domain protein
CL176_06415	COG0431	NADPH-dependent FMN reductase
CL176_06415	COG1053	succinate dehydrogenase
CL176_06415	COG3976	FMN-binding domain protein
CL176_06425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CL176_06455	COG1175	transmembrane transport
CL176_06465	COG3842	ATPase activity
CL176_06520	COG1053	succinate dehydrogenase
CL176_06520	COG3976	FMN-binding domain protein
CL176_06525	COG1053	succinate dehydrogenase
CL176_06525	COG3976	FMN-binding domain protein
CL176_06550	COG1053	succinate dehydrogenase
CL176_06550	COG3976	FMN-binding domain protein
CL176_06560	COG1053	succinate dehydrogenase
CL176_06585	COG2382	esterase
CL176_06590	COG0514	ATP-dependent DNA helicase (RecQ)
CL176_06600	COG2151	metal-sulfur cluster biosynthetic enzyme
CL176_06605	COG0561	phosphatase activity
CL176_06625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CL176_06630	COG1959	2 iron, 2 sulfur cluster binding
CL176_06640	COG1125	glycine betaine transport
CL176_06640	COG0517	IMP dehydrogenase activity
CL176_06645	COG1837	Belongs to the UPF0109 family
CL176_06650	COG0228	four-way junction DNA binding
CL176_06655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CL176_06660	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CL176_06700	COG1053	succinate dehydrogenase
CL176_06715	COG3344	reverse transcriptase
CL176_06720	COG3344	reverse transcriptase
CL176_06725	COG2211	Major facilitator Superfamily
CL176_06725	COG2190	(PTS) system
CL176_06730	COG0517	IMP dehydrogenase activity
CL176_06730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CL176_06735	COG1486	melibiose metabolic process
CL176_06740	COG1263	PTS System
CL176_06740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_06745	COG3976	FMN-binding domain protein
CL176_06745	COG1053	succinate dehydrogenase
CL176_06750	COG1609	Transcriptional regulator
CL176_06755	COG1621	beta-fructofuranosidase activity
CL176_06765	COG1940	carbohydrate kinase activity
CL176_06770	COG1621	beta-fructofuranosidase activity
CL176_06775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_06775	COG1263	PTS System
CL176_06775	COG2190	(PTS) system
CL176_06780	COG1609	Transcriptional regulator
CL176_06785	COG0402	S-adenosylhomocysteine deaminase activity
CL176_06795	COG3842	ATPase activity
CL176_06805	COG1176	ABC-type spermidine putrescine transport system, permease component I
CL176_06810	COG1012	belongs to the aldehyde dehydrogenase family
CL176_06815	COG1012	belongs to the aldehyde dehydrogenase family
CL176_06830	COG4372	Transposase
CL176_06845	COG2217	Heavy metal translocating P-type atpase
CL176_06850	COG1301	dicarboxylic acid transport
CL176_06865	COG0431	NADPH-dependent FMN reductase
CL176_06865	COG1053	succinate dehydrogenase
CL176_06865	COG3976	FMN-binding domain protein
CL176_06885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL176_06895	COG0786	glutamate:sodium symporter activity
CL176_06905	COG3485	protocatechuate 3,4-dioxygenase
CL176_06910	COG3485	protocatechuate 3,4-dioxygenase
CL176_06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CL176_06935	COG1473	amidohydrolase
CL176_06950	COG1473	amidohydrolase
CL176_06965	COG5646	InterPro IPR014922
CL176_07045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL176_07070	COG0450	alkyl hydroperoxide reductase
CL176_07095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CL176_07095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_07095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CL176_07105	COG1482	cell wall glycoprotein biosynthetic process
CL176_07110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CL176_07125	COG2323	membrane
CL176_07135	COG0140	phosphoribosyl-ATP diphosphatase activity
CL176_07135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CL176_07140	COG0107	imidazoleglycerol-phosphate synthase activity
CL176_07145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CL176_07150	COG0131	Imidazoleglycerol-phosphate dehydratase
CL176_07160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CL176_07165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CL176_07175	COG1473	amidohydrolase
CL176_07180	COG0167	dihydroorotate dehydrogenase activity
CL176_07195	COG0540	Belongs to the ATCase OTCase family
CL176_07200	COG1132	(ABC) transporter
CL176_07205	COG1132	(ABC) transporter
CL176_07210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CL176_07215	COG1393	Belongs to the ArsC family
CL176_07220	COG1764	response to oxidative stress
CL176_07230	COG1132	(ABC) transporter
CL176_07240	COG1489	DNA binding
CL176_07260	COG0640	Transcriptional regulator
CL176_07295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CL176_07300	COG4684	Psort location CytoplasmicMembrane, score
CL176_07310	COG0564	pseudouridine synthase activity
CL176_07315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CL176_07330	COG1074	ATP-dependent DNA helicase activity
CL176_07335	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CL176_07345	COG2195	Cleaves the N-terminal amino acid of tripeptides
CL176_07355	COG2384	SAM-dependent methyltransferase
CL176_07360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CL176_07365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CL176_07370	COG0358	DNA primase activity
CL176_07375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CL176_07380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CL176_07385	COG0544	peptidyl-prolyl cis-trans isomerase activity
CL176_07390	COG3331	DNA recombination
CL176_07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CL176_07400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CL176_07415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CL176_07440	COG5582	Belongs to the UPF0302 family
CL176_07460	COG0539	negative regulation of cytoplasmic translation
CL176_07465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CL176_07475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CL176_07480	COG1187	pseudouridine synthase activity
CL176_07485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CL176_07490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CL176_07505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CL176_07525	COG0205	6-phosphofructokinase activity
CL176_07530	COG0587	DNA-directed DNA polymerase activity
CL176_07535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CL176_07540	COG2255	four-way junction helicase activity
CL176_07555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CL176_07560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CL176_07570	COG1132	(ABC) transporter
CL176_07575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CL176_07585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CL176_07590	COG1418	mRNA catabolic process
CL176_07595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CL176_07600	COG1058	Belongs to the CinA family
CL176_07600	COG1546	Belongs to the CinA family
CL176_07605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CL176_07610	COG1426	Protein conserved in bacteria
CL176_07615	COG0612	Peptidase, M16
CL176_07620	COG0612	Peptidase, M16
CL176_07645	COG1744	ABC transporter substrate-binding protein PnrA-like
CL176_07650	COG1674	ftsk spoiiie
CL176_07655	COG1254	Belongs to the acylphosphatase family
CL176_07660	COG0706	membrane insertase activity
CL176_07665	COG5002	protein histidine kinase activity
CL176_07675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CL176_07680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CL176_07685	COG1940	carbohydrate kinase activity
CL176_07695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CL176_07730	COG3830	Belongs to the UPF0237 family
CL176_07740	COG2801	Transposase and inactivated derivatives
CL176_07750	COG0513	Belongs to the DEAD box helicase family
CL176_07755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CL176_07760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CL176_07765	COG4109	DRTGG domain
CL176_07770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CL176_07775	COG1862	Preprotein translocase
CL176_07780	COG0343	queuine tRNA-ribosyltransferase activity
CL176_07790	COG0204	Acyl-transferase
CL176_07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CL176_07810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CL176_07815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CL176_07815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CL176_07825	COG0300	oxidoreductase activity
CL176_07830	COG1234	tRNA 3'-trailer cleavage
CL176_07835	COG2755	lipolytic protein G-D-S-L family
CL176_07835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CL176_07840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL176_07845	COG0751	glycine-tRNA ligase activity
CL176_07855	COG1381	Involved in DNA repair and RecF pathway recombination
CL176_07860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CL176_07865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CL176_07870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CL176_07880	COG1702	phosphate starvation-inducible protein PhoH
CL176_07885	COG1610	YqeY-like protein
CL176_07890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CL176_07895	COG0735	belongs to the Fur family
CL176_07905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CL176_07910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CL176_07915	COG0124	histidyl-tRNA synthetase
CL176_07930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CL176_07935	COG1490	D-aminoacyl-tRNA deacylase activity
CL176_07940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CL176_07955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CL176_07960	COG2264	protein methyltransferase activity
CL176_07970	COG3599	regulation of cell shape
CL176_07980	COG0116	Belongs to the methyltransferase superfamily
CL176_07985	COG0328	RNA-DNA hybrid ribonuclease activity
CL176_08000	COG1597	lipid kinase activity
CL176_08020	COG1473	amidohydrolase
CL176_08025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CL176_08035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CL176_08040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CL176_08050	COG0301	tRNA thio-modification
CL176_08055	COG1104	cysteine desulfurase activity
CL176_08065	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CL176_08075	COG1126	abc transporter atp-binding protein
CL176_08080	COG0765	amino acid transport
CL176_08085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CL176_08095	COG0494	nUDIX hydrolase
CL176_08105	COG3853	Toxic anion resistance protein (TelA)
CL176_08115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CL176_08120	COG3599	regulation of cell shape
CL176_08130	COG0762	integral membrane protein
CL176_08140	COG0849	cell division
CL176_08145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CL176_08155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CL176_08165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CL176_08170	COG0768	penicillin binding
CL176_08185	COG2001	Belongs to the MraZ family
CL176_08200	COG1077	Cell shape determining protein MreB Mrl
CL176_08205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CL176_08215	COG3425	synthase
CL176_08225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CL176_08230	COG0009	L-threonylcarbamoyladenylate synthase
CL176_08235	COG2890	protein-(glutamine-N5) methyltransferase activity
CL176_08240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CL176_08245	COG1435	thymidine kinase activity
CL176_08255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CL176_08260	COG1811	Na channel or pump
CL176_08270	COG0628	permease
CL176_08275	COG2706	6-phosphogluconolactonase activity
CL176_08285	COG1968	undecaprenyl-diphosphatase activity
CL176_08290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CL176_08295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CL176_08300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CL176_08305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CL176_08320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CL176_08330	COG0537	adenosine 5'-monophosphoramidase activity
CL176_08360	COG4717	serine-type aminopeptidase activity
CL176_08365	COG0420	3'-5' exonuclease activity
CL176_08370	COG3679	Belongs to the UPF0342 family
CL176_08375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CL176_08380	COG0297	glycogen (starch) synthase activity
CL176_08385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CL176_08390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CL176_08405	COG0346	lactoylglutathione lyase activity
CL176_08410	COG0295	cytidine deaminase activity
CL176_08430	COG0058	SHG alpha-glucan phosphorylase activity
CL176_08440	COG0217	transcriptional regulatory protein
CL176_08445	COG2135	peptidase activity
CL176_08455	COG0628	permease
CL176_08460	COG0765	amino acid transport
CL176_08465	COG1126	abc transporter atp-binding protein
CL176_08470	COG1876	peptidase activity
CL176_08475	COG0656	L-ascorbic acid biosynthetic process
CL176_08480	COG3853	Toxic anion resistance protein (TelA)
CL176_08500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CL176_08520	COG2217	Heavy metal translocating P-type atpase
CL176_08540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CL176_08565	COG0469	pyruvate kinase activity
CL176_08570	COG1126	abc transporter atp-binding protein
CL176_08575	COG0765	amino acid transport
CL176_08580	COG0719	Fe-S assembly protein
CL176_08585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CL176_08590	COG0251	oxidation-reduction process
CL176_08595	COG2151	metal-sulfur cluster biosynthetic enzyme
CL176_08605	COG0028	Belongs to the TPP enzyme family
CL176_08610	COG0440	acetolactate synthase activity
CL176_08615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CL176_08620	COG1119	ATPase activity
CL176_08640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CL176_08645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CL176_08650	COG1116	anion transmembrane transporter activity
CL176_08670	COG1164	Oligoendopeptidase f
CL176_08675	COG1028	Short-chain dehydrogenase reductase Sdr
CL176_08705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL176_08710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CL176_08715	COG1397	ADP-ribosylglycohydrolase
CL176_08730	COG3716	PTS system mannose fructose sorbose family IID component
CL176_08740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_08740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_08750	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CL176_08755	COG1492	cobalamin metabolic process
CL176_08760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CL176_08780	COG0280	phosphate acetyltransferase
CL176_08785	COG4820	ethanolamine utilization protein (EutJ)
CL176_08790	COG1902	pentaerythritol trinitrate reductase activity
CL176_08795	COG3192	ethanolamine utilization protein
CL176_08810	COG4869	propanediol catabolic process
CL176_08825	COG1012	belongs to the aldehyde dehydrogenase family
CL176_08825	COG1454	alcohol dehydrogenase
CL176_08835	COG4816	utilization protein
CL176_08840	COG4302	ethanolamine ammonia-lyase activity
CL176_08845	COG4303	Ethanolamine ammonia lyase large subunit
CL176_08870	COG2096	Adenosyltransferase
CL176_08875	COG4917	ethanolamine utilization protein
CL176_08880	COG4810	utilization protein
CL176_08890	COG4372	Transposase
CL176_08900	COG1120	ATPase activity
CL176_08905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CL176_08930	COG0113	porphobilinogen synthase activity
CL176_08940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CL176_08945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CL176_08945	COG1648	precorrin-2 dehydrogenase activity
CL176_08950	COG2096	Adenosyltransferase
CL176_08965	COG1587	Uroporphyrinogen-III synthase
CL176_08965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CL176_08985	COG2875	Belongs to the precorrin methyltransferase family
CL176_08990	COG2242	protein methyltransferase activity
CL176_09000	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CL176_09010	COG1797	cobyrinic acid a,c-diamide synthase activity
CL176_09015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CL176_09020	COG0716	FMN binding
CL176_09025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CL176_09040	COG1120	ATPase activity
CL176_09080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CL176_09095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CL176_09120	COG2514	catechol 2,3-dioxygenase activity
CL176_09125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CL176_09145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CL176_09170	COG0431	NADPH-dependent FMN reductase
CL176_09195	COG2814	Major facilitator Superfamily
CL176_09200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CL176_09205	COG0284	orotidine-5'-phosphate decarboxylase activity
CL176_09245	COG0084	hydrolase, TatD family'
CL176_09250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CL176_09260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CL176_09265	COG0302	gtp cyclohydrolase
CL176_09270	COG1418	mRNA catabolic process
CL176_09275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CL176_09275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CL176_09285	COG0285	dihydrofolate synthase activity
CL176_09290	COG1253	flavin adenine dinucleotide binding
CL176_09295	COG1464	Belongs to the NlpA lipoprotein family
CL176_09300	COG3842	ATPase activity
CL176_09320	COG0395	ABC-type sugar transport system, permease component
CL176_09345	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CL176_09350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CL176_09355	COG2017	converts alpha-aldose to the beta-anomer
CL176_09380	COG2801	Transposase and inactivated derivatives
CL176_09385	COG3250	beta-galactosidase activity
CL176_09390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CL176_09400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CL176_09410	COG2017	converts alpha-aldose to the beta-anomer
CL176_09415	COG2169	Transcriptional regulator
CL176_09420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CL176_09430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CL176_09455	COG0602	queuosine metabolic process
CL176_09460	COG1328	CTP reductase activity
CL176_09485	COG2337	Toxic component of a toxin-antitoxin (TA) module
CL176_09490	COG3457	Alanine racemase
CL176_09500	COG2217	Heavy metal translocating P-type atpase
CL176_09505	COG2217	Heavy metal translocating P-type atpase
CL176_09545	COG1705	Flagellar rod assembly protein muramidase FlgJ
CL176_09545	COG1388	LysM domain
CL176_09565	COG0732	type I restriction modification DNA specificity domain
CL176_09575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CL176_09610	COG1028	Short-chain dehydrogenase reductase Sdr
CL176_09615	COG0561	phosphatase activity
CL176_09635	COG1725	Transcriptional regulator
CL176_09650	COG2205	protein histidine kinase activity
CL176_09655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CL176_09695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CL176_09710	COG1484	DNA-dependent DNA replication
CL176_09755	COG2205	protein histidine kinase activity
CL176_09790	COG0745	RESPONSE REGULATOR receiver
CL176_09880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CL176_09930	COG1396	sequence-specific DNA binding
CL176_09935	COG1396	sequence-specific DNA binding
CL176_09950	COG4555	ABC transporter
CL176_10025	COG0791	NLP P60 protein
CL176_10025	COG0741	lytic transglycosylase activity
CL176_10055	COG4166	transmembrane transport
CL176_10060	COG3949	Membrane
CL176_10065	COG0285	dihydrofolate synthase activity
CL176_10075	COG3591	Belongs to the peptidase S1B family
CL176_10080	COG2326	polyphosphate kinase activity
CL176_10085	COG0564	pseudouridine synthase activity
CL176_10090	COG0753	catalase activity
CL176_10095	COG2084	Dehydrogenase
CL176_10100	COG0179	Fumarylacetoacetate (FAA) hydrolase
CL176_10105	COG0179	Fumarylacetoacetate (FAA) hydrolase
CL176_10125	COG1309	transcriptional regulator
CL176_10130	COG0110	maltose O-acetyltransferase activity
CL176_10145	COG0436	Aminotransferase
CL176_10155	COG0561	phosphatase activity
CL176_10170	COG0243	molybdopterin cofactor binding
CL176_10180	COG1120	ATPase activity
CL176_10190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CL176_10330	COG0270	DNA (cytosine-5-)-methyltransferase activity
CL176_10355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CL176_10360	COG1854	S-ribosylhomocysteine lyase activity
CL176_10370	COG0561	phosphatase activity
CL176_10385	COG2183	response to ionizing radiation
CL176_10425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CL176_10430	COG1687	branched-chain amino acid
CL176_10435	COG0561	phosphatase activity
CL176_10440	COG2032	superoxide dismutase activity
CL176_10460	COG1757	Na H antiporter
CL176_10465	COG0667	Aldo Keto reductase
CL176_10475	COG0516	GMP reductase activity
CL176_10485	COG1263	PTS System
CL176_10485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CL176_10495	COG3142	Participates in the control of copper homeostasis
CL176_10505	COG3189	MarR family transcriptional regulator
CL176_10510	COG0018	arginyl-trna synthetase
CL176_10520	COG3764	Sortase (surface protein transpeptidase)
CL176_10530	COG1380	Effector of murein hydrolase LrgA
CL176_10535	COG1346	cytolysis
CL176_10545	COG0083	homoserine kinase activity
CL176_10550	COG0460	homoserine dehydrogenase
CL176_10555	COG0527	aspartate kinase activity
CL176_10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CL176_10565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CL176_10570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CL176_10575	COG0693	protein deglycase activity
CL176_10590	COG1744	ABC transporter substrate-binding protein PnrA-like
CL176_10610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CL176_10615	COG1640	4-alpha-glucanotransferase
CL176_10620	COG2217	Heavy metal translocating P-type atpase
CL176_10630	COG1523	belongs to the glycosyl hydrolase 13 family
CL176_10640	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CL176_10655	COG0786	glutamate:sodium symporter activity
CL176_10660	COG1131	(ABC) transporter
CL176_10680	COG2197	response regulator
CL176_10705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CL176_10705	COG0519	Catalyzes the synthesis of GMP from XMP
CL176_10710	COG1072	(Pantothenic acid kinase))
CL176_10730	COG1304	FMN binding
CL176_10745	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CL176_10750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CL176_10765	COG1136	(ABC) transporter
CL176_10765	COG0577	efflux transmembrane transporter activity
CL176_10770	COG0596	Alpha beta hydrolase
CL176_10780	COG0463	Glycosyl transferase, family 2
CL176_10795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CL176_10815	COG0280	phosphate acetyltransferase
CL176_10845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CL176_10850	COG0488	(ABC) transporter
CL176_10855	COG0217	transcriptional regulatory protein
CL176_10860	COG0386	Belongs to the glutathione peroxidase family
CL176_10870	COG0516	GMP reductase activity
CL176_10870	COG0517	IMP dehydrogenase activity
CL176_10880	COG0411	ABC transporter
CL176_10890	COG0559	Belongs to the binding-protein-dependent transport system permease family
CL176_10900	COG0039	L-malate dehydrogenase activity
CL176_10920	COG0066	3-isopropylmalate dehydratase activity
CL176_10925	COG0473	3-isopropylmalate dehydrogenase activity
CL176_10955	COG1131	(ABC) transporter
CL176_10965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CL176_10975	COG0588	phosphoglycerate mutase activity
CL176_10980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CL176_10985	COG1121	(ABC) transporter
CL176_10990	COG0803	Belongs to the bacterial solute-binding protein 9 family
CL176_11020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CL176_11025	COG2059	Chromate
CL176_11035	COG0583	DNA-binding transcription factor activity
CL176_11055	COG0101	tRNA pseudouridine synthase activity
CL176_11065	COG1122	ATPase activity
CL176_11070	COG1122	ATPase activity
CL176_11075	COG0203	ribosomal protein L17
CL176_11080	COG0202	RNA polymerase activity
CL176_11090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CL176_11095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CL176_11100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CL176_11110	COG0201	protein transport
CL176_11115	COG0200	Binds to the 23S rRNA
CL176_11120	COG1841	ribosomal large subunit assembly
CL176_11125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CL176_11130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CL176_11135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CL176_11140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CL176_11145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CL176_11150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CL176_11160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CL176_11165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CL176_11190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CL176_11195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CL176_11200	COG0089	rRNA binding
CL176_11205	COG0088	Forms part of the polypeptide exit tunnel
CL176_11210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CL176_11215	COG0051	transcription antitermination factor activity, RNA binding
CL176_11220	COG2521	methyltransferase
CL176_11220	COG2136	Putative SAM-dependent methyltransferase
CL176_11235	COG1126	abc transporter atp-binding protein
CL176_11245	COG0668	transmembrane transport
CL176_11250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CL176_11255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CL176_11260	COG0049	tRNA binding
CL176_11265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CL176_11270	COG1668	transmembrane transport
CL176_11275	COG4152	abc transporter atp-binding protein
CL176_11285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CL176_11290	COG1045	serine acetyltransferase
CL176_11295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CL176_11300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CL176_11315	COG0037	tRNA processing
CL176_11320	COG0745	RESPONSE REGULATOR receiver
CL176_11325	COG5002	protein histidine kinase activity
CL176_11330	COG1098	S1 RNA binding domain
CL176_11340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CL176_11345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CL176_11350	COG0193	aminoacyl-tRNA hydrolase activity
CL176_11355	COG4466	Protein conserved in bacteria
CL176_11365	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CL176_11370	COG0084	hydrolase, TatD family'
CL176_11375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL176_11375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL176_11385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CL176_11395	COG2249	NAD(P)H dehydrogenase (quinone) activity
CL176_11400	COG5002	protein histidine kinase activity
CL176_11400	COG3850	Histidine kinase
CL176_11405	COG0745	RESPONSE REGULATOR receiver
CL176_11415	COG1481	regulation of sporulation
CL176_11425	COG1660	Displays ATPase and GTPase activities
CL176_11430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CL176_11435	COG0492	ferredoxin-NADP+ reductase activity
CL176_11440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CL176_11445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CL176_11450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CL176_11455	COG1983	PspC domain protein
CL176_11465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CL176_11470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CL176_11475	COG0704	Plays a role in the regulation of phosphate uptake
CL176_11480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CL176_11485	COG0581	inorganic phosphate transmembrane transporter activity
CL176_11490	COG0573	inorganic phosphate transmembrane transporter activity
CL176_11495	COG5002	protein histidine kinase activity
CL176_11500	COG0745	RESPONSE REGULATOR receiver
CL176_11505	COG2177	Part of the ABC transporter FtsEX involved in
CL176_11510	COG2884	Cell division ATP-binding protein ftsE
CL176_11515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CL176_11520	COG0653	protein targeting
CL176_11535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CL176_11545	COG1597	lipid kinase activity
CL176_11550	COG0446	pyridine nucleotide-disulphide oxidoreductase
CL176_11565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL176_11570	COG1739	Uncharacterized protein family UPF0029
CL176_11575	COG1307	EDD domain protein, DegV family
CL176_11580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CL176_11590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CL176_11600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CL176_11605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CL176_11615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CL176_11625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_11630	COG3711	transcriptional antiterminator
CL176_11635	COG2213	PTS system mannitol-specific
CL176_11640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CL176_11645	COG1121	(ABC) transporter
CL176_11650	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CL176_11655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CL176_11660	COG2738	Putative neutral zinc metallopeptidase
CL176_11675	COG4120	Belongs to the binding-protein-dependent transport system permease family
CL176_11710	COG1132	(ABC) transporter
CL176_11725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CL176_11760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CL176_11770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CL176_11775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CL176_11790	COG1268	BioY protein
CL176_11795	COG0656	L-ascorbic acid biosynthetic process
CL176_11800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CL176_11800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CL176_11800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CL176_11805	COG1105	Belongs to the carbohydrate kinase PfkB family
CL176_11810	COG1349	DNA-binding transcription factor activity
CL176_11815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CL176_11860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CL176_11875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CL176_11885	COG2813	Specifically methylates the guanine in position
CL176_11890	COG0561	phosphatase activity
CL176_11900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CL176_11905	COG0081	regulation of translation
CL176_11910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CL176_11915	COG0656	L-ascorbic acid biosynthetic process
CL176_11930	COG3976	FMN-binding domain protein
CL176_11930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CL176_11945	COG0250	Participates in transcription elongation, termination and antitermination
CL176_11950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CL176_11955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CL176_11965	COG3688	RNA-binding protein containing a PIN domain
CL176_11970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CL176_11975	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CL176_11980	COG0215	cysteine-tRNA ligase activity
CL176_11985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CL176_11990	COG4956	integral membrane protein (PIN domain superfamily)
CL176_12000	COG0756	dUTP diphosphatase activity
CL176_12010	COG0174	glutamine synthetase
CL176_12020	COG0305	Participates in initiation and elongation during chromosome replication
CL176_12025	COG0359	binds to the 23S rRNA
CL176_12040	COG0629	single-stranded DNA binding
CL176_12045	COG0360	Binds together with S18 to 16S ribosomal RNA
CL176_12050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CL176_12055	COG0187	DNA topoisomerase II activity