locus-tag	class	description
I4Q36_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I4Q36_00010	COG0592	DNA-directed DNA polymerase activity
I4Q36_00020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4Q36_00025	COG0785	Cytochrome C biogenesis protein
I4Q36_00030	COG2501	S4 domain
I4Q36_00040	COG0187	DNA topoisomerase II activity
I4Q36_00055	COG0629	single-stranded DNA binding
I4Q36_00060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I4Q36_00070	COG0359	binds to the 23S rRNA
I4Q36_00075	COG0305	Participates in initiation and elongation during chromosome replication
I4Q36_00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I4Q36_00085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I4Q36_00095	COG0789	Transcriptional regulator
I4Q36_00105	COG0284	orotidine-5'-phosphate decarboxylase activity
I4Q36_00115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q36_00125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I4Q36_00130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I4Q36_00135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I4Q36_00140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4Q36_00145	COG1307	EDD domain protein, DegV family
I4Q36_00150	COG1739	Uncharacterized protein family UPF0029
I4Q36_00155	COG1307	EDD domain protein, DegV family
I4Q36_00165	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I4Q36_00185	COG0653	protein targeting
I4Q36_00190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I4Q36_00195	COG2884	Cell division ATP-binding protein ftsE
I4Q36_00200	COG2177	Part of the ABC transporter FtsEX involved in
I4Q36_00205	COG3842	ATPase activity
I4Q36_00210	COG0756	dUTP diphosphatase activity
I4Q36_00220	COG4956	integral membrane protein (PIN domain superfamily)
I4Q36_00225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I4Q36_00235	COG0215	cysteine-tRNA ligase activity
I4Q36_00240	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I4Q36_00245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4Q36_00250	COG3688	RNA-binding protein containing a PIN domain
I4Q36_00265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4Q36_00270	COG0250	Participates in transcription elongation, termination and antitermination
I4Q36_00280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I4Q36_00285	COG0081	regulation of translation
I4Q36_00290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I4Q36_00295	COG0222	ribosome binding
I4Q36_00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4Q36_00320	COG0745	RESPONSE REGULATOR receiver
I4Q36_00335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4Q36_00385	COG0542	response to heat
I4Q36_00405	COG0590	tRNA wobble adenosine to inosine editing
I4Q36_00415	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I4Q36_00420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I4Q36_00430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I4Q36_00435	COG3870	Protein conserved in bacteria
I4Q36_00450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I4Q36_00455	COG2827	Endonuclease containing a URI domain
I4Q36_00460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I4Q36_00475	COG2818	Glycosylase
I4Q36_00480	COG2731	YhcH YjgK YiaL family protein
I4Q36_00490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I4Q36_00510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4Q36_00545	COG2321	neutral zinc metallopeptidase
I4Q36_00550	COG0726	polysaccharide deacetylase
I4Q36_00585	COG4120	Belongs to the binding-protein-dependent transport system permease family
I4Q36_00590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q36_00625	COG0410	ABC transporter
I4Q36_00630	COG0517	IMP dehydrogenase activity
I4Q36_00630	COG0516	GMP reductase activity
I4Q36_00640	COG2197	response regulator
I4Q36_00645	COG1131	(ABC) transporter
I4Q36_00660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I4Q36_00665	COG0049	tRNA binding
I4Q36_00670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I4Q36_00675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I4Q36_00680	COG0668	transmembrane transport
I4Q36_00685	COG0051	transcription antitermination factor activity, RNA binding
I4Q36_00690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I4Q36_00700	COG0089	rRNA binding
I4Q36_00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I4Q36_00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I4Q36_00735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I4Q36_00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I4Q36_00750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I4Q36_00760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I4Q36_00770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I4Q36_00775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I4Q36_00780	COG1841	ribosomal large subunit assembly
I4Q36_00785	COG0200	Binds to the 23S rRNA
I4Q36_00795	COG0563	adenylate kinase activity
I4Q36_00805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I4Q36_00810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I4Q36_00815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I4Q36_00820	COG0202	RNA polymerase activity
I4Q36_00825	COG0203	ribosomal protein L17
I4Q36_00835	COG1122	ATPase activity
I4Q36_00840	COG1122	ATPase activity
I4Q36_00850	COG0101	tRNA pseudouridine synthase activity
I4Q36_00855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q36_00860	COG0656	L-ascorbic acid biosynthetic process
I4Q36_00875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4Q36_00885	COG1116	anion transmembrane transporter activity
I4Q36_00905	COG1268	BioY protein
I4Q36_00910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I4Q36_00910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I4Q36_00925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I4Q36_00940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4Q36_00950	COG0681	Belongs to the peptidase S26 family
I4Q36_00960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4Q36_00965	COG1253	flavin adenine dinucleotide binding
I4Q36_00970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4Q36_00980	COG1121	(ABC) transporter
I4Q36_00985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4Q36_01000	COG4372	Transposase
I4Q36_01010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4Q36_01015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I4Q36_01020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I4Q36_01025	COG4122	O-methyltransferase activity
I4Q36_01040	COG0515	serine threonine protein kinase
I4Q36_01050	COG0561	phosphatase activity
I4Q36_01060	COG0745	RESPONSE REGULATOR receiver
I4Q36_01065	COG5002	protein histidine kinase activity
I4Q36_01080	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q36_01080	COG1388	LysM domain
I4Q36_01085	COG1214	PFAM Peptidase M22, glycoprotease
I4Q36_01100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I4Q36_01105	COG1725	Transcriptional regulator
I4Q36_01110	COG1131	(ABC) transporter
I4Q36_01120	COG4166	transmembrane transport
I4Q36_01125	COG0601	transmembrane transport
I4Q36_01130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q36_01135	COG0444	Belongs to the ABC transporter superfamily
I4Q36_01140	COG4608	Belongs to the ABC transporter superfamily
I4Q36_01240	COG1979	alcohol dehydrogenase
I4Q36_01245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I4Q36_01250	COG0459	protein refolding
I4Q36_01260	COG0737	Belongs to the 5'-nucleotidase family
I4Q36_01265	COG3842	ATPase activity
I4Q36_01270	COG1175	transmembrane transport
I4Q36_01285	COG0740	serine-type endopeptidase activity
I4Q36_01290	COG2390	Transcriptional regulator
I4Q36_01300	COG0126	phosphoglycerate kinase activity
I4Q36_01315	COG0148	phosphopyruvate hydratase activity
I4Q36_01320	COG0778	Nitroreductase
I4Q36_01335	COG1611	Belongs to the LOG family
I4Q36_01345	COG3655	Transcriptional regulator
I4Q36_01360	COG0577	efflux transmembrane transporter activity
I4Q36_01360	COG1136	(ABC) transporter
I4Q36_01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_01370	COG1263	PTS System
I4Q36_01370	COG2190	(PTS) system
I4Q36_01375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q36_01375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q36_01380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I4Q36_01385	COG0237	dephospho-CoA kinase activity
I4Q36_01400	COG1484	DNA-dependent DNA replication
I4Q36_01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4Q36_01415	COG0765	amino acid transport
I4Q36_01430	COG1837	Belongs to the UPF0109 family
I4Q36_01435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4Q36_01440	COG1321	iron dependent repressor
I4Q36_01440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4Q36_01445	COG1121	(ABC) transporter
I4Q36_01450	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4Q36_01460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I4Q36_01465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I4Q36_01470	COG0167	dihydroorotate dehydrogenase activity
I4Q36_01480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I4Q36_01485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I4Q36_01490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4Q36_01490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I4Q36_01495	COG0631	protein serine/threonine phosphatase activity
I4Q36_01500	COG2815	serine threonine protein kinase
I4Q36_01500	COG0515	serine threonine protein kinase
I4Q36_01505	COG1162	GTPase activity
I4Q36_01510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4Q36_01520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I4Q36_01525	COG1302	Protein conserved in bacteria
I4Q36_01530	COG1461	Dihydroxyacetone kinase
I4Q36_01535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I4Q36_01540	COG0416	fatty acid biosynthetic process
I4Q36_01545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4Q36_01555	COG4608	Belongs to the ABC transporter superfamily
I4Q36_01560	COG0601	transmembrane transport
I4Q36_01565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q36_01570	COG1058	Belongs to the CinA family
I4Q36_01570	COG1546	Belongs to the CinA family
I4Q36_01580	COG3853	Toxic anion resistance protein (TelA)
I4Q36_01590	COG1129	ABC transporter
I4Q36_01595	COG1121	(ABC) transporter
I4Q36_01610	COG1606	tRNA processing
I4Q36_01615	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I4Q36_01620	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I4Q36_01645	COG1115	amino acid carrier protein
I4Q36_01650	COG0549	Belongs to the carbamate kinase family
I4Q36_01655	COG0542	response to heat
I4Q36_01660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I4Q36_01670	COG1691	(AIR) carboxylase
I4Q36_01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4Q36_01680	COG1121	(ABC) transporter
I4Q36_01710	COG1269	ATP hydrolysis coupled proton transport
I4Q36_01715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4Q36_01735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I4Q36_01740	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I4Q36_01745	COG1394	ATPase activity, coupled to movement of substances
I4Q36_01750	COG1132	(ABC) transporter
I4Q36_01770	COG1686	Belongs to the peptidase S11 family
I4Q36_01785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I4Q36_01800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q36_01820	COG0438	transferase activity, transferring glycosyl groups
I4Q36_01830	COG1764	response to oxidative stress
I4Q36_01835	COG1272	protein, Hemolysin III
I4Q36_01850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4Q36_01855	COG1534	Rna-binding protein
I4Q36_01860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I4Q36_01865	COG1713	HD superfamily hydrolase involved in NAD metabolism
I4Q36_01870	COG0799	negative regulation of ribosome biogenesis
I4Q36_01875	COG2226	methyltransferase
I4Q36_01880	COG1323	Belongs to the UPF0348 family
I4Q36_01885	COG1609	Transcriptional regulator
I4Q36_01910	COG2211	Major facilitator Superfamily
I4Q36_01915	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_01925	COG0191	fructose-bisphosphate aldolase activity
I4Q36_01930	COG0166	Belongs to the GPI family
I4Q36_01955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I4Q36_01975	COG0488	(ABC) transporter
I4Q36_01990	COG1393	Belongs to the ArsC family
I4Q36_02000	COG0640	Transcriptional regulator
I4Q36_02030	COG0254	rRNA binding
I4Q36_02035	COG0582	viral genome integration into host DNA
I4Q36_02120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4Q36_02130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I4Q36_02140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4Q36_02145	COG2017	converts alpha-aldose to the beta-anomer
I4Q36_02150	COG4989	oxidoreductase activity
I4Q36_02155	COG0561	phosphatase activity
I4Q36_02180	COG4804	nuclease activity
I4Q36_02185	COG4804	nuclease activity
I4Q36_02195	COG1363	Peptidase, m42
I4Q36_02205	COG4667	esterase of the alpha-beta hydrolase superfamily
I4Q36_02210	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q36_02220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I4Q36_02225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4Q36_02230	COG1396	sequence-specific DNA binding
I4Q36_02240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I4Q36_02245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I4Q36_02255	COG2357	RelA SpoT domain protein
I4Q36_02260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4Q36_02270	COG0564	pseudouridine synthase activity
I4Q36_02275	COG2239	Acts as a magnesium transporter
I4Q36_02295	COG1335	isochorismatase
I4Q36_02300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I4Q36_02305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4Q36_02315	COG1131	(ABC) transporter
I4Q36_02330	COG0681	Belongs to the peptidase S26 family
I4Q36_02360	COG0616	signal peptide processing
I4Q36_02365	COG2738	Putative neutral zinc metallopeptidase
I4Q36_02370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I4Q36_02380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I4Q36_02420	COG1131	(ABC) transporter
I4Q36_02430	COG0228	four-way junction DNA binding
I4Q36_02435	COG1979	alcohol dehydrogenase
I4Q36_02440	COG0534	Mate efflux family protein
I4Q36_02445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4Q36_02450	COG2261	transglycosylase associated protein
I4Q36_02465	COG4470	Protein conserved in bacteria
I4Q36_02470	COG0647	UMP catabolic process
I4Q36_02480	COG0673	inositol 2-dehydrogenase activity
I4Q36_02495	COG1609	Transcriptional regulator
I4Q36_02500	COG4209	transmembrane transport
I4Q36_02505	COG0395	ABC-type sugar transport system, permease component
I4Q36_02510	COG1653	transport
I4Q36_02520	COG1940	carbohydrate kinase activity
I4Q36_02525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I4Q36_02535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I4Q36_02540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I4Q36_02545	COG0297	glycogen (starch) synthase activity
I4Q36_02550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I4Q36_02555	COG1466	dna polymerase III delta subunit
I4Q36_02565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I4Q36_02580	COG1523	belongs to the glycosyl hydrolase 13 family
I4Q36_02585	COG1874	Beta-galactosidase
I4Q36_02585	COG0366	Alpha amylase catalytic
I4Q36_02610	COG1435	thymidine kinase activity
I4Q36_02620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I4Q36_02625	COG2890	protein-(glutamine-N5) methyltransferase activity
I4Q36_02630	COG0009	L-threonylcarbamoyladenylate synthase
I4Q36_02635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I4Q36_02640	COG0183	Belongs to the thiolase family
I4Q36_02645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I4Q36_02655	COG0527	aspartate kinase activity
I4Q36_02660	COG0460	homoserine dehydrogenase
I4Q36_02665	COG0083	homoserine kinase activity
I4Q36_02675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I4Q36_02685	COG1653	transport
I4Q36_02705	COG1285	pathogenesis
I4Q36_02720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I4Q36_02725	COG0072	phenylalanine-tRNA ligase activity
I4Q36_02725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q36_02730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I4Q36_02735	COG2217	Heavy metal translocating P-type atpase
I4Q36_02740	COG1968	undecaprenyl-diphosphatase activity
I4Q36_02745	COG2190	(PTS) system
I4Q36_02745	COG1263	PTS System
I4Q36_02745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_02765	COG1131	(ABC) transporter
I4Q36_02775	COG0525	valine-tRNA ligase activity
I4Q36_02780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4Q36_02785	COG4605	iron ion homeostasis
I4Q36_02790	COG4604	ABC transporter, ATP-binding protein
I4Q36_02795	COG4607	ABC-type enterochelin transport system periplasmic component
I4Q36_02850	COG0511	ligase activity, forming carbon-carbon bonds
I4Q36_02850	COG5016	pyruvate
I4Q36_02855	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I4Q36_02860	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_02880	COG0024	Methionine aminopeptidase
I4Q36_02910	COG0058	SHG alpha-glucan phosphorylase activity
I4Q36_02915	COG1640	4-alpha-glucanotransferase
I4Q36_02920	COG1609	Transcriptional regulator
I4Q36_02925	COG0356	it plays a direct role in the translocation of protons across the membrane
I4Q36_02935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I4Q36_02940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4Q36_02945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I4Q36_02950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I4Q36_02955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I4Q36_02980	COG1857	crispr-associated protein
I4Q36_02995	COG1518	maintenance of DNA repeat elements
I4Q36_03000	COG1199	ATP-dependent helicase activity
I4Q36_03000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I4Q36_03005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q36_03140	COG3763	UPF0154 protein
I4Q36_03145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4Q36_03150	COG1045	serine acetyltransferase
I4Q36_03165	COG0537	adenosine 5'-monophosphoramidase activity
I4Q36_03175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4Q36_03180	COG0513	Belongs to the DEAD box helicase family
I4Q36_03185	COG0750	zinc metalloprotease
I4Q36_03190	COG2176	DNA-directed DNA polymerase activity
I4Q36_03195	COG4493	Belongs to the UPF0637 family
I4Q36_03200	COG4476	Belongs to the UPF0223 family
I4Q36_03205	COG0483	inositol monophosphate 1-phosphatase activity
I4Q36_03210	COG1217	gtp-binding protein TYPA
I4Q36_03220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4Q36_03235	COG2001	Belongs to the MraZ family
I4Q36_03250	COG0768	penicillin binding
I4Q36_03255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I4Q36_03265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I4Q36_03285	COG3842	ATPase activity
I4Q36_03290	COG1176	ABC-type spermidine putrescine transport system, permease component I
I4Q36_03300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I4Q36_03310	COG0772	Belongs to the SEDS family
I4Q36_03315	COG4471	UPF0298 protein
I4Q36_03320	COG0742	ribosomal rna small subunit methyltransferase
I4Q36_03325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I4Q36_03330	COG1278	Cold shock
I4Q36_03340	COG2723	6-phospho-beta-galactosidase activity
I4Q36_03345	COG4209	transmembrane transport
I4Q36_03350	COG0395	ABC-type sugar transport system, permease component
I4Q36_03365	COG5520	Belongs to the glycosyl hydrolase 30 family
I4Q36_03375	COG1609	Transcriptional regulator
I4Q36_03380	COG4209	transmembrane transport
I4Q36_03385	COG0395	ABC-type sugar transport system, permease component
I4Q36_03400	COG1940	carbohydrate kinase activity
I4Q36_03410	COG3448	diguanylate cyclase activity
I4Q36_03410	COG4175	Glycine betaine
I4Q36_03430	COG1349	DNA-binding transcription factor activity
I4Q36_03435	COG3711	transcriptional antiterminator
I4Q36_03440	COG2190	(PTS) system
I4Q36_03440	COG1263	PTS System
I4Q36_03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_03455	COG2723	6-phospho-beta-galactosidase activity
I4Q36_03465	COG1012	belongs to the aldehyde dehydrogenase family
I4Q36_03470	COG4619	ABC transporter
I4Q36_03475	COG0390	transport system, permease component
I4Q36_03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4Q36_03485	COG1960	acyl-CoA dehydrogenase activity
I4Q36_03490	COG0583	DNA-binding transcription factor activity
I4Q36_03495	COG0183	Belongs to the thiolase family
I4Q36_03500	COG1960	acyl-CoA dehydrogenase activity
I4Q36_03505	COG1250	3-hydroxyacyl-CoA dehydrogenase
I4Q36_03510	COG1024	Enoyl-CoA hydratase
I4Q36_03515	COG0427	acetyl-CoA hydrolase
I4Q36_03520	COG2972	Histidine kinase
I4Q36_03525	COG2204	response regulator
I4Q36_03530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4Q36_03530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4Q36_03535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4Q36_03545	COG0785	Cytochrome C biogenesis protein
I4Q36_03565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I4Q36_03580	COG1597	lipid kinase activity
I4Q36_03600	COG1846	Transcriptional regulator
I4Q36_03605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4Q36_03610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I4Q36_03620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I4Q36_03630	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q36_03635	COG4708	membrane
I4Q36_03640	COG1077	Cell shape determining protein MreB Mrl
I4Q36_03645	COG1792	Involved in formation and maintenance of cell shape
I4Q36_03655	COG0735	belongs to the Fur family
I4Q36_03665	COG2302	S4 RNA-binding domain
I4Q36_03670	COG3599	regulation of cell shape
I4Q36_03675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I4Q36_03680	COG4545	Glutaredoxin-related protein
I4Q36_03685	COG0295	cytidine deaminase activity
I4Q36_03690	COG0346	lactoylglutathione lyase activity
I4Q36_03695	COG0531	amino acid
I4Q36_03705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I4Q36_03710	COG0622	Phosphoesterase
I4Q36_03715	COG0517	IMP dehydrogenase activity
I4Q36_03735	COG1252	NADH dehydrogenase
I4Q36_03770	COG0587	DNA-directed DNA polymerase activity
I4Q36_03775	COG0205	6-phosphofructokinase activity
I4Q36_03785	COG1131	(ABC) transporter
I4Q36_03825	COG0534	Mate efflux family protein
I4Q36_03855	COG0251	oxidation-reduction process
I4Q36_03875	COG1426	Protein conserved in bacteria
I4Q36_03880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I4Q36_03890	COG0542	response to heat
I4Q36_03915	COG1131	(ABC) transporter
I4Q36_03925	COG1131	(ABC) transporter
I4Q36_03930	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I4Q36_03935	COG1388	LysM domain
I4Q36_03935	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q36_03940	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4Q36_03940	COG3103	Sh3 type 3 domain protein
I4Q36_03940	COG4991	sh3 domain protein
I4Q36_03945	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4Q36_03960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I4Q36_03965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I4Q36_03980	COG2115	Belongs to the xylose isomerase family
I4Q36_03985	COG1070	Carbohydrate kinase
I4Q36_03990	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q36_03995	COG1129	ABC transporter
I4Q36_04000	COG4214	carbohydrate transport
I4Q36_04035	COG0719	Fe-S assembly protein
I4Q36_04040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I4Q36_04045	COG0822	iron-sulfur transferase activity
I4Q36_04050	COG0719	Fe-S assembly protein
I4Q36_04055	COG1131	(ABC) transporter
I4Q36_04060	COG0842	Transport permease protein
I4Q36_04075	COG0752	glycyl-tRNA synthetase alpha subunit
I4Q36_04080	COG0751	glycine-tRNA ligase activity
I4Q36_04095	COG1234	tRNA 3'-trailer cleavage
I4Q36_04100	COG0300	oxidoreductase activity
I4Q36_04110	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I4Q36_04110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I4Q36_04115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q36_04120	COG1442	glycosyl transferase family 8
I4Q36_04125	COG2514	catechol 2,3-dioxygenase activity
I4Q36_04130	COG1490	D-aminoacyl-tRNA deacylase activity
I4Q36_04140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4Q36_04145	COG0438	transferase activity, transferring glycosyl groups
I4Q36_04155	COG2309	aminopeptidase activity
I4Q36_04160	COG0716	FMN binding
I4Q36_04165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I4Q36_04175	COG1316	TRANSCRIPTIONal
I4Q36_04185	COG2315	Protein conserved in bacteria
I4Q36_04195	COG4109	DRTGG domain
I4Q36_04200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I4Q36_04205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I4Q36_04215	COG2384	SAM-dependent methyltransferase
I4Q36_04220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I4Q36_04225	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4Q36_04235	COG1744	ABC transporter substrate-binding protein PnrA-like
I4Q36_04240	COG3845	ABC transporter
I4Q36_04245	COG4603	Belongs to the binding-protein-dependent transport system permease family
I4Q36_04250	COG1079	Belongs to the binding-protein-dependent transport system permease family
I4Q36_04255	COG0745	RESPONSE REGULATOR receiver
I4Q36_04260	COG5002	protein histidine kinase activity
I4Q36_04270	COG1136	(ABC) transporter
I4Q36_04305	COG1802	Transcriptional regulator
I4Q36_04305	COG4626	Terminase
I4Q36_04310	COG3177	Filamentation induced by cAMP protein fic
I4Q36_04400	COG4372	Transposase
I4Q36_04415	COG0366	Alpha amylase catalytic
I4Q36_04440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q36_04445	COG0706	membrane insertase activity
I4Q36_04450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I4Q36_04460	COG1254	Belongs to the acylphosphatase family
I4Q36_04465	COG1674	ftsk spoiiie
I4Q36_04480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I4Q36_04485	COG0539	negative regulation of cytoplasmic translation
I4Q36_04490	COG1160	GTP binding
I4Q36_04495	COG0776	regulation of translation
I4Q36_04510	COG0768	penicillin binding
I4Q36_04520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4Q36_04525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4Q36_04530	COG0758	DNA mediated transformation
I4Q36_04535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I4Q36_04550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I4Q36_04555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I4Q36_04560	COG0019	diaminopimelate decarboxylase activity
I4Q36_04565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4Q36_04570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I4Q36_04575	COG0463	Glycosyl transferase, family 2
I4Q36_04590	COG0789	Transcriptional regulator
I4Q36_04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4Q36_04615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4Q36_04620	COG3679	Belongs to the UPF0342 family
I4Q36_04630	COG4717	serine-type aminopeptidase activity
I4Q36_04635	COG3481	metal-dependent phosphohydrolase, HD sub domain
I4Q36_04660	COG4806	L-rhamnose isomerase
I4Q36_04675	COG4589	Belongs to the CDS family
I4Q36_04680	COG0488	(ABC) transporter
I4Q36_04685	COG1879	ABC-type sugar transport system periplasmic component
I4Q36_04700	COG0561	phosphatase activity
I4Q36_04705	COG2151	metal-sulfur cluster biosynthetic enzyme
I4Q36_04710	COG0204	Acyl-transferase
I4Q36_04720	COG0343	queuine tRNA-ribosyltransferase activity
I4Q36_04725	COG1862	Preprotein translocase
I4Q36_04730	COG3620	sequence-specific DNA binding
I4Q36_04740	COG0779	Required for maturation of 30S ribosomal subunits
I4Q36_04745	COG0195	Participates in both transcription termination and antitermination
I4Q36_04750	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I4Q36_04765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I4Q36_04770	COG0438	transferase activity, transferring glycosyl groups
I4Q36_04790	COG1215	transferase activity, transferring glycosyl groups
I4Q36_04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I4Q36_04800	COG4472	Bacterial protein of unknown function (DUF965)
I4Q36_04805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I4Q36_04810	COG3906	Belongs to the UPF0473 family
I4Q36_04815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4Q36_04820	COG0572	uridine kinase
I4Q36_04825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I4Q36_04835	COG4585	Histidine kinase
I4Q36_04840	COG2197	response regulator
I4Q36_04845	COG4841	protein insertion into membrane
I4Q36_04860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I4Q36_04865	COG0745	RESPONSE REGULATOR receiver
I4Q36_04870	COG5002	protein histidine kinase activity
I4Q36_04880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I4Q36_04885	COG1597	lipid kinase activity
I4Q36_04890	COG1196	nuclear chromosome segregation
I4Q36_04985	COG1191	sigma factor activity
I4Q36_05010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q36_05010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q36_05060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I4Q36_05070	COG0270	DNA (cytosine-5-)-methyltransferase activity
I4Q36_05080	COG1802	Transcriptional regulator
I4Q36_05080	COG4626	Terminase
I4Q36_05095	COG4695	Portal protein
I4Q36_05100	COG0740	serine-type endopeptidase activity
I4Q36_05250	COG1725	Transcriptional regulator
I4Q36_05255	COG1129	ABC transporter
I4Q36_05255	COG0842	Transport permease protein
I4Q36_05270	COG1418	mRNA catabolic process
I4Q36_05275	COG4974	Belongs to the 'phage' integrase family
I4Q36_05280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I4Q36_05285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I4Q36_05295	COG1610	YqeY-like protein
I4Q36_05300	COG1702	phosphate starvation-inducible protein PhoH
I4Q36_05310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I4Q36_05315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I4Q36_05320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I4Q36_05325	COG1381	Involved in DNA repair and RecF pathway recombination
I4Q36_05335	COG0765	amino acid transport
I4Q36_05340	COG1126	abc transporter atp-binding protein
I4Q36_05355	COG0571	ribonuclease III activity
I4Q36_05360	COG1132	(ABC) transporter
I4Q36_05365	COG1132	(ABC) transporter
I4Q36_05375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4Q36_05380	COG1349	DNA-binding transcription factor activity
I4Q36_05385	COG1105	Belongs to the carbohydrate kinase PfkB family
I4Q36_05390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q36_05390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q36_05390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q36_05395	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I4Q36_05400	COG1074	ATP-dependent DNA helicase activity
I4Q36_05410	COG0456	acetyltransferase
I4Q36_05415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I4Q36_05420	COG0583	DNA-binding transcription factor activity
I4Q36_05425	COG0471	metal ion transport
I4Q36_05430	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
I4Q36_05435	COG1227	inorganic diphosphatase activity
I4Q36_05445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I4Q36_05455	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I4Q36_05470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4Q36_05475	COG1940	carbohydrate kinase activity
I4Q36_05480	COG0457	Tetratricopeptide repeat
I4Q36_05480	COG0705	Rhomboid family
I4Q36_05485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I4Q36_05505	COG0335	large ribosomal subunit rRNA binding
I4Q36_05510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I4Q36_05515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I4Q36_05520	COG2255	four-way junction helicase activity
I4Q36_05535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I4Q36_05540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I4Q36_05545	COG1692	metallophosphoesterase
I4Q36_05550	COG0673	inositol 2-dehydrogenase activity
I4Q36_05555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I4Q36_05570	COG0564	pseudouridine synthase activity
I4Q36_05575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I4Q36_05590	COG0552	protein localization to endoplasmic reticulum
I4Q36_05595	COG0561	phosphatase activity
I4Q36_05605	COG2070	2-Nitropropane dioxygenase
I4Q36_05625	COG1131	(ABC) transporter
I4Q36_05685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I4Q36_05700	COG1482	cell wall glycoprotein biosynthetic process
I4Q36_05715	COG1132	(ABC) transporter
I4Q36_05720	COG1132	(ABC) transporter
I4Q36_05725	COG3250	beta-galactosidase activity
I4Q36_05730	COG0366	Alpha amylase catalytic
I4Q36_05735	COG1187	pseudouridine synthase activity
I4Q36_05740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I4Q36_05745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I4Q36_05760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I4Q36_05770	COG2996	Protein conserved in bacteria
I4Q36_05775	COG0514	ATP-dependent DNA helicase (RecQ)
I4Q36_05785	COG0534	Mate efflux family protein
I4Q36_05795	COG0322	excinuclease ABC activity
I4Q36_05805	COG0604	alcohol dehydrogenase
I4Q36_05805	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q36_05805	COG3321	synthase
I4Q36_05860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I4Q36_05865	COG0358	DNA primase activity
I4Q36_05870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I4Q36_05875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I4Q36_05880	COG0544	peptidyl-prolyl cis-trans isomerase activity
I4Q36_05885	COG3331	DNA recombination
I4Q36_05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4Q36_05895	COG0681	Belongs to the peptidase S26 family
I4Q36_05900	COG0793	Belongs to the peptidase S41A family
I4Q36_05900	COG3409	Peptidoglycan-binding domain 1 protein
I4Q36_05905	COG0813	purine-nucleoside phosphorylase activity
I4Q36_05930	COG1393	Belongs to the ArsC family
I4Q36_05935	COG0484	heat shock protein binding
I4Q36_05945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I4Q36_05955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q36_05960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4Q36_05965	COG0196	riboflavin kinase activity
I4Q36_05980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I4Q36_05985	COG0187	DNA topoisomerase II activity
I4Q36_05995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I4Q36_06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4Q36_06020	COG0482	sulfurtransferase activity
I4Q36_06030	COG1104	cysteine desulfurase activity
I4Q36_06035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I4Q36_06050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I4Q36_06070	COG3623	hexulose-6-phosphate isomerase
I4Q36_06090	COG3037	sugar-specific permease SgaT UlaA
I4Q36_06095	COG1573	uracil-dna glycosylase
I4Q36_06100	COG0528	UMP kinase activity
I4Q36_06110	COG0052	Belongs to the universal ribosomal protein uS2 family
I4Q36_06125	COG1126	abc transporter atp-binding protein
I4Q36_06130	COG0765	amino acid transport
I4Q36_06140	COG0671	phosphoesterase, PA-phosphatase related
I4Q36_06155	COG4864	UPF0365 protein
I4Q36_06170	COG3118	belongs to the thioredoxin family
I4Q36_06185	COG4166	transmembrane transport
I4Q36_06190	COG2116	formate transmembrane transporter activity
I4Q36_06205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q36_06220	COG2755	lipolytic protein G-D-S-L family
I4Q36_06220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I4Q36_06235	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I4Q36_06240	COG2824	Alkylphosphonate utilization operon protein PhnA
I4Q36_06260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4Q36_06265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I4Q36_06270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q36_06275	COG0562	UDP-galactopyranose mutase
I4Q36_06280	COG0481	GTPase activity
I4Q36_06290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I4Q36_06295	COG2723	6-phospho-beta-galactosidase activity
I4Q36_06300	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4Q36_06305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q36_06310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q36_06315	COG3711	transcriptional antiterminator
I4Q36_06320	COG2239	Acts as a magnesium transporter
I4Q36_06325	COG3833	ABC-type maltose transport systems, permease component
I4Q36_06330	COG1175	transmembrane transport
I4Q36_06340	COG1053	succinate dehydrogenase
I4Q36_06355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I4Q36_06365	COG5646	InterPro IPR014922
I4Q36_06370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I4Q36_06375	COG0488	(ABC) transporter
I4Q36_06380	COG0318	PFAM AMP-dependent synthetase and ligase
I4Q36_06385	COG1266	CAAX protease self-immunity
I4Q36_06395	COG1012	belongs to the aldehyde dehydrogenase family
I4Q36_06395	COG1454	alcohol dehydrogenase
I4Q36_06410	COG4555	ABC transporter
I4Q36_06415	COG0233	cytoplasmic translational termination
I4Q36_06420	COG0577	efflux transmembrane transporter activity
I4Q36_06425	COG1136	(ABC) transporter
I4Q36_06430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I4Q36_06440	COG1811	Na channel or pump
I4Q36_06450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I4Q36_06455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I4Q36_06460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I4Q36_06475	COG3599	regulation of cell shape
I4Q36_06485	COG0116	Belongs to the methyltransferase superfamily
I4Q36_06490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I4Q36_06495	COG0439	Biotin carboxylase
I4Q36_06505	COG1984	allophanate hydrolase subunit 2
I4Q36_06510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I4Q36_06515	COG1914	H( )-stimulated, divalent metal cation uptake system
I4Q36_06535	COG0494	nUDIX hydrolase
I4Q36_06540	COG1373	ATPase (AAA superfamily
I4Q36_06555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4Q36_06570	COG4851	CamS sex pheromone cAM373 precursor
I4Q36_06575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I4Q36_06585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I4Q36_06595	COG0488	(ABC) transporter
I4Q36_06615	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I4Q36_06615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4Q36_06665	COG0534	Mate efflux family protein
I4Q36_06670	COG0433	COG0433 Predicted ATPase
I4Q36_06675	COG0534	Mate efflux family protein
I4Q36_06680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I4Q36_06695	COG1609	Transcriptional regulator
I4Q36_06700	COG3425	synthase
I4Q36_06715	COG0628	permease
I4Q36_06720	COG2706	6-phosphogluconolactonase activity
I4Q36_06745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4Q36_06750	COG3458	cephalosporin-C deacetylase activity
I4Q36_06760	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I4Q36_06765	COG0395	ABC-type sugar transport system, permease component
I4Q36_06770	COG1175	transmembrane transport
I4Q36_06790	COG0604	alcohol dehydrogenase
I4Q36_06795	COG4608	Belongs to the ABC transporter superfamily
I4Q36_06800	COG0444	Belongs to the ABC transporter superfamily
I4Q36_06805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q36_06810	COG0601	transmembrane transport
I4Q36_06815	COG4166	transmembrane transport
I4Q36_06830	COG1653	transport
I4Q36_06835	COG0395	ABC-type sugar transport system, permease component
I4Q36_06840	COG4209	transmembrane transport
I4Q36_06850	COG1609	Transcriptional regulator
I4Q36_06855	COG5492	domain, Protein
I4Q36_06865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I4Q36_06910	COG1598	PFAM Uncharacterised protein family UPF0150
I4Q36_06975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I4Q36_06975	COG0519	Catalyzes the synthesis of GMP from XMP
I4Q36_06985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4Q36_07000	COG1304	FMN binding
I4Q36_07020	COG1567	CRISPR-associated RAMP protein, Csm4 family
I4Q36_07025	COG1337	RAMP superfamily
I4Q36_07055	COG2081	HI0933 family
I4Q36_07070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4Q36_07085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I4Q36_07100	COG0242	peptide deformylase activity
I4Q36_07105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I4Q36_07115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I4Q36_07120	COG0557	exoribonuclease II activity
I4Q36_07145	COG3764	Sortase (surface protein transpeptidase)
I4Q36_07170	COG1668	transmembrane transport
I4Q36_07175	COG4152	abc transporter atp-binding protein
I4Q36_07200	COG2176	DNA-directed DNA polymerase activity
I4Q36_07205	COG1518	maintenance of DNA repeat elements
I4Q36_07220	COG1857	crispr-associated protein
I4Q36_07255	COG1222	aaa ATPase
I4Q36_07260	COG2188	Transcriptional regulator
I4Q36_07275	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I4Q36_07290	COG1079	Belongs to the binding-protein-dependent transport system permease family
I4Q36_07295	COG4603	Belongs to the binding-protein-dependent transport system permease family
I4Q36_07300	COG3845	ABC transporter
I4Q36_07305	COG1744	ABC transporter substrate-binding protein PnrA-like
I4Q36_07315	COG0159	tryptophan synthase activity
I4Q36_07320	COG2190	(PTS) system
I4Q36_07340	COG1484	DNA-dependent DNA replication
I4Q36_07345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I4Q36_07355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4Q36_07380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4Q36_07395	COG1316	TRANSCRIPTIONal
I4Q36_07405	COG0489	protein tyrosine kinase activity
I4Q36_07515	COG0166	Belongs to the GPI family
I4Q36_07520	COG0539	negative regulation of cytoplasmic translation
I4Q36_07525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I4Q36_07530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I4Q36_07535	COG0492	ferredoxin-NADP+ reductase activity
I4Q36_07540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4Q36_07545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I4Q36_07550	COG2183	response to ionizing radiation
I4Q36_07555	COG1609	Transcriptional regulator
I4Q36_07570	COG0668	transmembrane transport
I4Q36_07590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4Q36_07595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4Q36_07600	COG1187	pseudouridine synthase activity
I4Q36_07605	COG2244	polysaccharide biosynthetic process
I4Q36_07610	COG0495	leucyl-tRNA aminoacylation
I4Q36_07620	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q36_07665	COG0772	Belongs to the SEDS family
I4Q36_07670	COG1295	ribonuclease BN
I4Q36_07675	COG0588	phosphoglycerate mutase activity
I4Q36_07680	COG2252	PERMEase
I4Q36_07690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I4Q36_07695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I4Q36_07700	COG1193	negative regulation of DNA recombination
I4Q36_07745	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4Q36_07755	COG0826	peptidase U32
I4Q36_07760	COG0826	peptidase U32
I4Q36_07765	COG4466	Protein conserved in bacteria
I4Q36_07770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I4Q36_07775	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4Q36_07785	COG0084	hydrolase, TatD family'
I4Q36_07790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q36_07790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q36_07800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I4Q36_07805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I4Q36_07810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I4Q36_07815	COG1983	PspC domain protein
I4Q36_07840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4Q36_07850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I4Q36_07870	COG1215	transferase activity, transferring glycosyl groups
I4Q36_07880	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_07890	COG2813	Specifically methylates the guanine in position
I4Q36_07895	COG0561	phosphatase activity
I4Q36_07910	COG1464	Belongs to the NlpA lipoprotein family
I4Q36_07915	COG2011	ABC-type metal ion transport system permease component
I4Q36_07920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q36_07925	COG0018	arginyl-trna synthetase
I4Q36_07930	COG3639	organic phosphonate transmembrane transporter activity
I4Q36_07940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I4Q36_07945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4Q36_07950	COG1181	Belongs to the D-alanine--D-alanine ligase family
I4Q36_07965	COG1704	LemA family
I4Q36_07975	COG1523	belongs to the glycosyl hydrolase 13 family
I4Q36_07980	COG0708	Exodeoxyribonuclease III
I4Q36_07995	COG1104	cysteine desulfurase activity
I4Q36_08000	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I4Q36_08005	COG2333	competence protein COMEC
I4Q36_08005	COG0658	competence protein
I4Q36_08010	COG1555	photosystem II stabilization
I4Q36_08010	COG1596	polysaccharide export
I4Q36_08055	COG3557	Belongs to the UPF0374 family
I4Q36_08060	COG1132	(ABC) transporter
I4Q36_08075	COG2137	regulation of response to DNA damage stimulus
I4Q36_08080	COG0497	DNA recombination
I4Q36_08085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I4Q36_08090	COG0142	geranyltranstransferase activity
I4Q36_08095	COG1722	exodeoxyribonuclease VII activity
I4Q36_08100	COG1570	exodeoxyribonuclease VII activity
I4Q36_08120	COG0667	Aldo Keto reductase
I4Q36_08125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I4Q36_08130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I4Q36_08135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I4Q36_08145	COG1803	Methylglyoxal synthase
I4Q36_08150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4Q36_08160	COG2003	Belongs to the UPF0758 family
I4Q36_08165	COG2003	Belongs to the UPF0758 family
I4Q36_08170	COG0285	dihydrofolate synthase activity
I4Q36_08175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I4Q36_08195	COG1758	RNA polymerase activity
I4Q36_08205	COG1316	TRANSCRIPTIONal
I4Q36_08210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4Q36_08215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4Q36_08240	COG0366	Alpha amylase catalytic
I4Q36_08245	COG0395	ABC-type sugar transport system, permease component
I4Q36_08250	COG1175	transmembrane transport
I4Q36_08255	COG1653	transport
I4Q36_08260	COG3345	alpha-galactosidase
I4Q36_08265	COG2207	Transcriptional regulator
I4Q36_08275	COG0280	phosphate acetyltransferase
I4Q36_08280	COG1854	S-ribosylhomocysteine lyase activity
I4Q36_08285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4Q36_08290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I4Q36_08305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I4Q36_08310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I4Q36_08315	COG0037	tRNA processing
I4Q36_08320	COG1098	S1 RNA binding domain
I4Q36_08330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I4Q36_08335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I4Q36_08340	COG0193	aminoacyl-tRNA hydrolase activity
I4Q36_08345	COG0039	L-malate dehydrogenase activity
I4Q36_08350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4Q36_08355	COG1302	Protein conserved in bacteria
I4Q36_08360	COG0006	proline dipeptidase activity
I4Q36_08395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I4Q36_08415	COG5503	Protein of unknown function (DUF1447)
I4Q36_08425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I4Q36_08435	COG3976	FMN-binding domain protein
I4Q36_08435	COG1053	succinate dehydrogenase
I4Q36_08445	COG0436	Aminotransferase
I4Q36_08450	COG1522	sequence-specific DNA binding
I4Q36_08465	COG0628	permease
I4Q36_08480	COG3279	Response regulator of the LytR AlgR family
I4Q36_08490	COG0745	RESPONSE REGULATOR receiver
I4Q36_08495	COG2357	RelA SpoT domain protein
I4Q36_08505	COG3250	beta-galactosidase activity
I4Q36_08515	COG1175	transmembrane transport
I4Q36_08530	COG0583	DNA-binding transcription factor activity
I4Q36_08535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I4Q36_08545	COG0072	phenylalanine-tRNA ligase activity
I4Q36_08550	COG1363	Peptidase, m42
I4Q36_08555	COG3250	beta-galactosidase activity
I4Q36_08560	COG2211	Major facilitator Superfamily
I4Q36_08590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4Q36_08595	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q36_08600	COG2160	L-arabinose isomerase activity
I4Q36_08610	COG1070	Carbohydrate kinase
I4Q36_08615	COG1609	Transcriptional regulator
I4Q36_08625	COG0510	thiamine kinase activity
I4Q36_08630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I4Q36_08640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I4Q36_08650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_08650	COG1263	PTS System
I4Q36_08660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I4Q36_08670	COG3534	alpha-L-arabinofuranosidase
I4Q36_08680	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q36_08685	COG3940	Belongs to the glycosyl hydrolase 43 family
I4Q36_08690	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q36_08700	COG0395	ABC-type sugar transport system, permease component
I4Q36_08710	COG1653	transport
I4Q36_08765	COG3408	Glycogen debranching enzyme
I4Q36_08770	COG0561	phosphatase activity
I4Q36_08805	COG0673	inositol 2-dehydrogenase activity
I4Q36_08825	COG0395	ABC-type sugar transport system, permease component
I4Q36_08830	COG1175	transmembrane transport
I4Q36_08840	COG2207	Transcriptional regulator
I4Q36_08865	COG1164	Oligoendopeptidase f
I4Q36_08875	COG4862	establishment of competence for transformation
I4Q36_08880	COG1393	Belongs to the ArsC family
I4Q36_08885	COG0180	Tryptophanyl-tRNA synthetase
I4Q36_08890	COG1185	polyribonucleotide nucleotidyltransferase activity
I4Q36_08895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I4Q36_08905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I4Q36_08905	COG2755	lipolytic protein G-D-S-L family
I4Q36_08910	COG0556	nucleotide-excision repair
I4Q36_08925	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q36_08925	COG1388	LysM domain
I4Q36_08930	COG0217	transcriptional regulatory protein
I4Q36_08935	COG0386	Belongs to the glutathione peroxidase family
I4Q36_08940	COG3684	Belongs to the aldolase LacD family
I4Q36_08950	COG2222	sugar isomerase
I4Q36_08965	COG5426	von Willebrand factor, type A
I4Q36_08970	COG0395	ABC-type sugar transport system, permease component
I4Q36_08975	COG1175	transmembrane transport
I4Q36_08980	COG1653	transport
I4Q36_08985	COG4977	sequence-specific DNA binding
I4Q36_08985	COG1917	Cupin 2, conserved barrel domain protein
I4Q36_08990	COG3716	PTS system mannose fructose sorbose family IID component
I4Q36_08995	COG3715	PTS system
I4Q36_09000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_09015	COG1132	(ABC) transporter
I4Q36_09050	COG0583	DNA-binding transcription factor activity
I4Q36_09055	COG1388	LysM domain
I4Q36_09055	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q36_09090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I4Q36_09115	COG1621	beta-fructofuranosidase activity
I4Q36_09120	COG1263	PTS System
I4Q36_09120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_09125	COG1609	Transcriptional regulator
I4Q36_09135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4Q36_09160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I4Q36_09165	COG1309	transcriptional regulator
I4Q36_09170	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4Q36_09170	COG3443	Belongs to the bacterial solute-binding protein 9 family
I4Q36_09175	COG1454	alcohol dehydrogenase
I4Q36_09180	COG1187	pseudouridine synthase activity
I4Q36_09205	COG0625	glutathione transferase activity
I4Q36_09225	COG1301	dicarboxylic acid transport
I4Q36_09235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4Q36_09240	COG1780	Probably involved in ribonucleotide reductase function
I4Q36_09265	COG0488	(ABC) transporter
I4Q36_09270	COG0516	GMP reductase activity
I4Q36_09275	COG1132	(ABC) transporter
I4Q36_09295	COG0438	transferase activity, transferring glycosyl groups
I4Q36_09305	COG1051	belongs to the nudix hydrolase family
I4Q36_09345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I4Q36_09370	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4Q36_09380	COG3850	Histidine kinase
I4Q36_09380	COG5002	protein histidine kinase activity
I4Q36_09385	COG0745	RESPONSE REGULATOR receiver
I4Q36_09390	COG0629	single-stranded DNA binding
I4Q36_09395	COG1481	regulation of sporulation
I4Q36_09405	COG1660	Displays ATPase and GTPase activities
I4Q36_09410	COG0488	(ABC) transporter
I4Q36_09425	COG3343	RNA polymerase activity
I4Q36_09435	COG0095	Lipoate-protein ligase
I4Q36_09440	COG1078	dGTPase activity
I4Q36_09455	COG1464	Belongs to the NlpA lipoprotein family
I4Q36_09460	COG2011	ABC-type metal ion transport system permease component
I4Q36_09465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q36_09470	COG0436	Aminotransferase
I4Q36_09475	COG1942	4-Oxalocrotonate Tautomerase
I4Q36_09495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I4Q36_09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4Q36_09520	COG0736	holo-[acyl-carrier-protein] synthase activity
I4Q36_09525	COG0513	Belongs to the DEAD box helicase family
I4Q36_09645	COG1408	metallophosphoesterase
I4Q36_09650	COG2116	formate transmembrane transporter activity
I4Q36_09655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4Q36_09665	COG1132	(ABC) transporter
I4Q36_09675	COG0745	RESPONSE REGULATOR receiver
I4Q36_09680	COG1418	mRNA catabolic process
I4Q36_09700	COG1902	pentaerythritol trinitrate reductase activity
I4Q36_09705	COG2211	Major facilitator Superfamily
I4Q36_09715	COG2723	6-phospho-beta-galactosidase activity
I4Q36_09720	COG4977	sequence-specific DNA binding
I4Q36_09720	COG1917	Cupin 2, conserved barrel domain protein
I4Q36_09725	COG1609	Transcriptional regulator
I4Q36_09735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4Q36_09740	COG1428	Deoxynucleoside kinase
I4Q36_09765	COG2211	Major facilitator Superfamily
I4Q36_09770	COG1309	transcriptional regulator
I4Q36_09780	COG2059	Chromate
I4Q36_09810	COG3250	beta-galactosidase activity
I4Q36_09815	COG2169	Transcriptional regulator
I4Q36_09815	COG1917	Cupin 2, conserved barrel domain protein
I4Q36_09830	COG3804	dihydrodipicolinate reductase
I4Q36_09835	COG4978	Transcriptional regulator
I4Q36_09835	COG0789	Transcriptional regulator
I4Q36_09840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4Q36_09845	COG1902	pentaerythritol trinitrate reductase activity
I4Q36_09850	COG0583	DNA-binding transcription factor activity
I4Q36_09865	COG1263	PTS System
I4Q36_09865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_09875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4Q36_09880	COG3442	glutamine amidotransferase
I4Q36_09885	COG0095	Lipoate-protein ligase
I4Q36_09895	COG1363	Peptidase, m42
I4Q36_09910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4Q36_09915	COG0431	NADPH-dependent FMN reductase
I4Q36_09915	COG1053	succinate dehydrogenase
I4Q36_09915	COG3976	FMN-binding domain protein
I4Q36_09920	COG1053	succinate dehydrogenase
I4Q36_09920	COG3976	FMN-binding domain protein
I4Q36_09920	COG0431	NADPH-dependent FMN reductase
I4Q36_09940	COG0602	queuosine metabolic process
I4Q36_09960	COG1496	oxidoreductase activity
I4Q36_09970	COG0740	serine-type endopeptidase activity
I4Q36_09980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I4Q36_09985	COG1737	Transcriptional regulator
I4Q36_09990	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_10015	COG3250	beta-galactosidase activity
I4Q36_10025	COG2723	6-phospho-beta-galactosidase activity
I4Q36_10030	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_10035	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q36_10040	COG2211	Major facilitator Superfamily
I4Q36_10045	COG4977	sequence-specific DNA binding
I4Q36_10045	COG1917	Cupin 2, conserved barrel domain protein
I4Q36_10050	COG2084	Dehydrogenase
I4Q36_10055	COG1929	Belongs to the glycerate kinase type-1 family
I4Q36_10060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4Q36_10065	COG4948	Mandelate Racemase Muconate Lactonizing
I4Q36_10070	COG4948	Mandelate Racemase Muconate Lactonizing
I4Q36_10075	COG2610	gluconate transmembrane transporter activity
I4Q36_10080	COG3835	regulator
I4Q36_10085	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I4Q36_10090	COG0511	ligase activity, forming carbon-carbon bonds
I4Q36_10100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I4Q36_10115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I4Q36_10120	COG0583	DNA-binding transcription factor activity
I4Q36_10125	COG2610	gluconate transmembrane transporter activity
I4Q36_10140	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q36_10150	COG0800	Aldolase
I4Q36_10165	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q36_10170	COG1312	Catalyzes the dehydration of D-mannonate
I4Q36_10180	COG0800	Aldolase
I4Q36_10185	COG2186	Transcriptional regulator
I4Q36_10190	COG3250	beta-galactosidase activity
I4Q36_10195	COG2211	Major facilitator Superfamily
I4Q36_10205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I4Q36_10210	COG0517	IMP dehydrogenase activity
I4Q36_10210	COG0516	GMP reductase activity
I4Q36_10215	COG1609	Transcriptional regulator
I4Q36_10225	COG3716	PTS system mannose fructose sorbose family IID component
I4Q36_10230	COG3715	PTS system
I4Q36_10235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_10240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4Q36_10250	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q36_10265	COG0012	GTP binding
I4Q36_10270	COG4481	Protein conserved in bacteria
I4Q36_10275	COG1475	DNA binding
I4Q36_10280	COG1192	Involved in chromosome partitioning
I4Q36_10290	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I4Q36_10295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I4Q36_10300	COG1970	mechanosensitive ion channel activity
I4Q36_10390	COG0569	domain protein
I4Q36_10395	COG1473	amidohydrolase
I4Q36_10400	COG0445	tRNA wobble uridine modification
I4Q36_10405	COG1051	belongs to the nudix hydrolase family
I4Q36_10410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I4Q36_10415	COG2188	Transcriptional regulator
I4Q36_10425	COG0366	Alpha amylase catalytic
I4Q36_10430	COG1263	PTS System
I4Q36_10430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q36_10435	COG1847	R3H domain protein
I4Q36_10440	COG0706	membrane insertase activity
I4Q36_10445	COG0594	ribonuclease P activity
I4Q36_10450	COG0230	Belongs to the bacterial ribosomal protein bL34 family