locus-tag	class	description
HMPREF9243_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HMPREF9243_0004	ENOG4105CQB	FAD linked oxidase domain protein
HMPREF9243_0005	ENOG410848D	S4 domain protein YaaA
HMPREF9243_0006	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HMPREF9243_0007	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HMPREF9243_0008	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HMPREF9243_0009	ENOG4108IUX	(ABC) transporter
HMPREF9243_0010	ENOG4105RHA	ABC transporter, permease
HMPREF9243_0013	ENOG4105HDK	L-asparaginase
HMPREF9243_0015	ENOG4105CH2	amidohydrolase
HMPREF9243_0016	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HMPREF9243_0017	ENOG4108UUM	single-stranded DNA-binding protein
HMPREF9243_0018	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HMPREF9243_0022	ENOG41083J0	(ABC) transporter
HMPREF9243_0023	ENOG4105C4B	ABC transporter, permease
HMPREF9243_0024	ENOG4105C4B	ABC transporter, permease
HMPREF9243_0025	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HMPREF9243_0026	ENOG4105CDU	Replicative dna helicase
HMPREF9243_0028	ENOG4105C0A	alcohol dehydrogenase
HMPREF9243_0032	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HMPREF9243_0044	ENOG4105DQ6	Transposase
HMPREF9243_0054	ENOG4105C28	cystathionine
HMPREF9243_0055	ENOG4105EGI	Transcriptional regulator
HMPREF9243_0058	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HMPREF9243_0059	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HMPREF9243_0065	ENOG4105RNB	
HMPREF9243_0066	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HMPREF9243_0070	ENOG4105DQ6	Transposase
HMPREF9243_0074	ENOG4105DWF	phosphomethylpyrimidine kinase
HMPREF9243_0076	ENOG4108EKI	Dehydrogenase
HMPREF9243_0080	ENOG4105DQ6	Transposase
HMPREF9243_0082	ENOG4105W2C	Glycosyl transferase
HMPREF9243_0088	ENOG4105DY9	regulatoR
HMPREF9243_0091	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HMPREF9243_0092	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HMPREF9243_0094	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HMPREF9243_0096	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HMPREF9243_0100	ENOG4105C87	Aminotransferase class I and II
HMPREF9243_0101	ENOG4105KV4	Transcriptional regulator
HMPREF9243_0102	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0105	ENOG4105E66	phosphoriboisomerase A
HMPREF9243_0106	ENOG4107YBY	Hydrolase
HMPREF9243_0108	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HMPREF9243_0109	ENOG41067SE	Tetr family transcriptional regulator
HMPREF9243_0110	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HMPREF9243_0113	ENOG4108TVJ	Nitroreductase
HMPREF9243_0114	ENOG4105C3M	thioredoxin reductase
HMPREF9243_0115	ENOG4105K63	Thioredoxin
HMPREF9243_0116	ENOG4105ECY	inositol monophosphatase
HMPREF9243_0118	ENOG4105CGU	Enoyl-CoA hydratase
HMPREF9243_0119	ENOG4105EA8	2-Nitropropane dioxygenase
HMPREF9243_0120	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HMPREF9243_0121	ENOG4105DND	Transcriptional regulator
HMPREF9243_0125	ENOG4105GIG	
HMPREF9243_0129	ENOG4105D01	(LipO)protein
HMPREF9243_0130	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HMPREF9243_0131	ENOG4108UMI	ABC transporter, permease
HMPREF9243_0138	ENOG4106CVF	DNA replication protein
HMPREF9243_0162	ENOG4105EKQ	RNA-directed DNA polymerase
HMPREF9243_0168	ENOG41071EZ	rRNA adenine N-6-methyltransferase
HMPREF9243_0177	ENOG4105MU5	relaxase mobilization nuclease domain protein
HMPREF9243_0192	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HMPREF9243_0196	ENOG4105DZR	Type I site-specific deoxyribonuclease
HMPREF9243_0201	ENOG4105E4P	ATPase (AAA
HMPREF9243_0208	ENOG4105DQ6	Transposase
HMPREF9243_0218	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0219	ENOG4105CHR	reductase
HMPREF9243_0220	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0221	ENOG4105C5Q	Transcriptional regulator
HMPREF9243_0222	ENOG4105E2X	shikimate dehydrogenase
HMPREF9243_0223	ENOG4105EMV	Major Facilitator
HMPREF9243_0224	ENOG4105FF2	Type I DHQase
HMPREF9243_0225	ENOG4105D4T	Citrate transporter
HMPREF9243_0231	ENOG4105C5Y	PTS System
HMPREF9243_0234	ENOG4108MRH	transcriptional regulatory protein
HMPREF9243_0236	ENOG4105C5I	Dehydrogenase
HMPREF9243_0237	ENOG4107RHR	regulatoR
HMPREF9243_0238	ENOG4105QEK	Transcriptional regulator
HMPREF9243_0239	ENOG4105DG6	mannose-6-phosphate isomerase
HMPREF9243_0240	ENOG4108VA3	3-hexulose-6-phosphate synthase
HMPREF9243_0241	ENOG41080HJ	6-phospho 3-hexuloisomerase
HMPREF9243_0242	ENOG4105DM4	PTS System
HMPREF9243_0245	ENOG4105PAD	Hydrolase
HMPREF9243_0246	ENOG4105DM4	PTS System
HMPREF9243_0247	ENOG4105DG6	mannose-6-phosphate isomerase
HMPREF9243_0250	ENOG4105DT3	PTS system, galactitol-specific IIc component
HMPREF9243_0258	ENOG4108XBJ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
HMPREF9243_0259	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HMPREF9243_0265	ENOG4105DQ6	Transposase
HMPREF9243_0268	ENOG4105D2N	Aldolase
HMPREF9243_0269	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HMPREF9243_0272	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HMPREF9243_0275	ENOG4108UHU	Aldolase
HMPREF9243_0280	ENOG4105F3R	pts system mannose fructose sorbose family iid
HMPREF9243_0281	ENOG4105KPI	PTS system sorbose subfamily IIB component
HMPREF9243_0283	ENOG4108JQ1	Dehydrogenase
HMPREF9243_0285	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HMPREF9243_0288	ENOG4105DQ6	Transposase
HMPREF9243_0291	ENOG4105CS2	ec 3.2.1.21
HMPREF9243_0294	ENOG4105EMD	TRANSCRIPTIONal
HMPREF9243_0295	ENOG4105VZJ	PTS System
HMPREF9243_0298	ENOG4105CK1	PTS System
HMPREF9243_0303	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HMPREF9243_0305	ENOG4105CHR	reductase
HMPREF9243_0307	ENOG4105J92	DNA-binding transcriptional activator GutM
HMPREF9243_0308	ENOG410787A	Pts system, glucitol sorbitol-specific
HMPREF9243_0309	ENOG4105DZY	Pts system, glucitol sorbitol-specific
HMPREF9243_0310	ENOG4105VI0	Pts system, glucitol sorbitol-specific
HMPREF9243_0311	ENOG4107R7Y	intracellular protease Pfpi family
HMPREF9243_0314	ENOG4105EA8	2-Nitropropane dioxygenase
HMPREF9243_0316	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
HMPREF9243_0317	ENOG4105D9N	nucleoside
HMPREF9243_0324	ENOG4105MUN	Divergent AAA domain
HMPREF9243_0335	ENOG4105DQ6	Transposase
HMPREF9243_0337	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HMPREF9243_0339	ENOG4105EYH	Exonuclease
HMPREF9243_0342	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HMPREF9243_0343	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HMPREF9243_0344	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HMPREF9243_0346	ENOG4105C3M	thioredoxin reductase
HMPREF9243_0352	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HMPREF9243_0353	ENOG4105CHW	UPF0052 protein
HMPREF9243_0354	ENOG4105CIE	May be required for sporulation (By similarity)
HMPREF9243_0355	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0356	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HMPREF9243_0358	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HMPREF9243_0359	ENOG4105BZU	Histidine kinase
HMPREF9243_0362	ENOG4105DR4	Methyltransferase
HMPREF9243_0363	ENOG4105DQ6	Transposase
HMPREF9243_0370	ENOG4105D1Q	UPF0246 protein
HMPREF9243_0371	ENOG4105CI1	PTS System
HMPREF9243_0372	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HMPREF9243_0373	ENOG4105K78	MarR family Transcriptional regulator
HMPREF9243_0376	ENOG4105CG3	alpha amylase, catalytic region
HMPREF9243_0377	ENOG410667J	hydrolase
HMPREF9243_0384	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HMPREF9243_0385	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HMPREF9243_0386	ENOG4105C8N	cysteinyl-tRNA synthetase
HMPREF9243_0387	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF9243_0388	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HMPREF9243_0389	ENOG4105M0M	Tetracycline resistance protein
HMPREF9243_0392	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HMPREF9243_0394	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HMPREF9243_0395	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HMPREF9243_0397	ENOG4108VZM	50s ribosomal protein L10
HMPREF9243_0398	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HMPREF9243_0399	ENOG4108M60	Transcriptional regulator
HMPREF9243_0400	ENOG4105D7K	pfkb domain protein
HMPREF9243_0401	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
HMPREF9243_0402	ENOG4107Y49	methyltransferase
HMPREF9243_0404	ENOG4105DQ6	Transposase
HMPREF9243_0405	ENOG4108IJ7	Glycine betaine
HMPREF9243_0410	ENOG4105CAG	UPF0210 protein
HMPREF9243_0411	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HMPREF9243_0412	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HMPREF9243_0413	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HMPREF9243_0414	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HMPREF9243_0416	ENOG4108WBT	adenosyltransferase
HMPREF9243_0426	ENOG4105CJ1	ABC, transporter
HMPREF9243_0428	ENOG4105PGM	cation diffusion facilitator family transporter
HMPREF9243_0429	ENOG4105KEX	transcriptional regulator, ctsr
HMPREF9243_0430	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HMPREF9243_0432	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HMPREF9243_0433	ENOG4108Z6B	deaminase
HMPREF9243_0435	ENOG4105C6E	dna polymerase iii
HMPREF9243_0436	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HMPREF9243_0437	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HMPREF9243_0438	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HMPREF9243_0439	ENOG4105FA2	dna polymerase iii
HMPREF9243_0441	ENOG41063V3	Involved in initiation control of chromosome replication (By similarity)
HMPREF9243_0442	ENOG41060K3	Methyltransferase
HMPREF9243_0444	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HMPREF9243_0446	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HMPREF9243_0447	ENOG4107VFR	oxidoreductase
HMPREF9243_0449	ENOG4105CHM	Aminotransferase
HMPREF9243_0450	ENOG4105DCI	Phosphohydrolase
HMPREF9243_0455	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HMPREF9243_0456	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HMPREF9243_0457	ENOG41082DI	50s ribosomal protein l31
HMPREF9243_0458	ENOG4108Z6X	(sortase) family
HMPREF9243_0462	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HMPREF9243_0463	ENOG4105C1J	atp-dependent rna helicase
HMPREF9243_0464	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HMPREF9243_0465	ENOG4108U5N	UPF0316 protein
HMPREF9243_0469	ENOG4107TXC	Transcriptional regulator
HMPREF9243_0471	ENOG4105DA5	(ABC) transporter
HMPREF9243_0473	ENOG4105C37	(CBS) domain
HMPREF9243_0477	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
HMPREF9243_0478	ENOG4105CKK	Glycosyl transferase, family 2
HMPREF9243_0484	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HMPREF9243_0487	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HMPREF9243_0488	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HMPREF9243_0489	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HMPREF9243_0490	ENOG4108JA2	transcriptioN-repair coupling factor
HMPREF9243_0492	ENOG41082I2	s4 domain protein
HMPREF9243_0494	ENOG41060GV	RNA binding s1 domain protein
HMPREF9243_0495	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HMPREF9243_0496	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HMPREF9243_0497	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HMPREF9243_0498	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HMPREF9243_0499	ENOG4105C6T	cysteine synthase
HMPREF9243_0500	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HMPREF9243_0501	ENOG4105CRK	lysyL-tRNA synthetase
HMPREF9243_0503	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HMPREF9243_0504	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HMPREF9243_0505	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HMPREF9243_0506	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HMPREF9243_0508	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HMPREF9243_0509	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HMPREF9243_0510	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HMPREF9243_0511	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HMPREF9243_0512	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF9243_0513	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HMPREF9243_0514	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HMPREF9243_0515	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HMPREF9243_0516	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HMPREF9243_0517	ENOG41082SA	50s ribosomal protein l29
HMPREF9243_0518	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HMPREF9243_0521	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF9243_0522	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HMPREF9243_0524	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HMPREF9243_0525	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HMPREF9243_0526	ENOG41087RB	50S ribosomal protein L30
HMPREF9243_0527	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HMPREF9243_0528	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HMPREF9243_0529	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HMPREF9243_0530	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HMPREF9243_0532	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HMPREF9243_0533	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HMPREF9243_0534	ENOG4108ZT0	50S ribosomal protein l17
HMPREF9243_0537	ENOG4108JJB	ABC transporter
HMPREF9243_0538	ENOG4108JJB	ABC transporter
HMPREF9243_0540	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HMPREF9243_0545	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HMPREF9243_0554	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HMPREF9243_0556	ENOG4105CSM	endonuclease III
HMPREF9243_0559	ENOG4108IJ8	ABC transporter
HMPREF9243_0562	ENOG4108DBC	nitroreductase
HMPREF9243_0563	ENOG4105C34	Pseudouridine synthase
HMPREF9243_0572	ENOG4105DZC	cytosine deaminase
HMPREF9243_0574	ENOG4105DEN	Luciferase family
HMPREF9243_0577	ENOG4108UVJ	appr-1-p processing domain protein
HMPREF9243_0580	ENOG4108URH	decarboxylase
HMPREF9243_0581	ENOG4107RBM	d-lactate dehydrogenase
HMPREF9243_0582	ENOG4105EY8	ABC transporter
HMPREF9243_0583	ENOG4105CMR	udp-glucose 4-epimerase
HMPREF9243_0588	ENOG410902V	Modulates RecA activity (By similarity)
HMPREF9243_0589	ENOG4105CEN	a g-specific adenine glycosylase
HMPREF9243_0590	ENOG4105EVI	UPF0374 protein
HMPREF9243_0592	ENOG4108IUM	Glycogen debranching enzyme
HMPREF9243_0593	ENOG4108V3A	UPF0421 protein
HMPREF9243_0595	ENOG4105II7	pyrroline-5-carboxylate reductase
HMPREF9243_0611	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
HMPREF9243_0613	ENOG4108IMY	Transcriptional regulator
HMPREF9243_0615	ENOG4105FGV	Chromate
HMPREF9243_0619	ENOG4105DQ6	Transposase
HMPREF9243_0627	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HMPREF9243_0636	ENOG4105ETE	Transcriptional regulator (LacI family
HMPREF9243_0637	ENOG4108HKT	sucrose-6-phosphate hydrolase
HMPREF9243_0638	ENOG4105C5Y	PTS System
HMPREF9243_0639	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HMPREF9243_0640	ENOG4105C5I	Dehydrogenase
HMPREF9243_0641	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
HMPREF9243_0642	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HMPREF9243_0643	ENOG4105BZ4	penicillin-binding protein
HMPREF9243_0644	ENOG4105WZB	UPF0342 protein
HMPREF9243_0646	ENOG4106D4I	domain protein
HMPREF9243_0647	ENOG4105EQI	Metal Dependent Phosphohydrolase
HMPREF9243_0648	ENOG4105X1N	Glycosyl transferase family 8
HMPREF9243_0649	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HMPREF9243_0651	ENOG4105K59	histidine triad (HIT) protein
HMPREF9243_0655	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HMPREF9243_0657	ENOG4108VDD	TRNA binding domain protein
HMPREF9243_0659	ENOG4105DFU	Cell wall formation (By similarity)
HMPREF9243_0660	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HMPREF9243_0665	ENOG4105C8T	Leucyl-tRNA synthetase
HMPREF9243_0667	ENOG4105CDA	abc transporter atp-binding protein
HMPREF9243_0669	ENOG4108HW4	amino acid AbC transporter
HMPREF9243_0670	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_0676	ENOG4108RWN	rrna methyltransferase
HMPREF9243_0678	ENOG4105KVH	Transcriptional regulator
HMPREF9243_0680	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HMPREF9243_0681	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HMPREF9243_0683	ENOG4108IJ2	phosphate acetyltransferase
HMPREF9243_0688	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HMPREF9243_0689	ENOG4108UIC	UPF0340 protein
HMPREF9243_0690	ENOG4105K8N	protein family UPF0079, ATPase
HMPREF9243_0694	ENOG4108JJB	ABC transporter
HMPREF9243_0695	ENOG4105CVJ	phosphoglycerate mutase
HMPREF9243_0699	ENOG4105D7T	ABC transporter
HMPREF9243_0702	ENOG4105CTZ	aminopeptidase c
HMPREF9243_0703	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
HMPREF9243_0704	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HMPREF9243_0708	ENOG4105ETE	Transcriptional regulator (LacI family
HMPREF9243_0710	ENOG4105ETZ	PTS System
HMPREF9243_0716	ENOG4105BZ1	(ABC) transporter
HMPREF9243_0718	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HMPREF9243_0720	ENOG4108WZW	RNA polymerase sigma
HMPREF9243_0725	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0728	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HMPREF9243_0730	ENOG4105CE4	GlcNAc 6-P deacetylase
HMPREF9243_0734	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HMPREF9243_0735	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HMPREF9243_0736	ENOG4108YYH	Nadph-dependent fmn reductase
HMPREF9243_0738	ENOG4105C7K	acetolactate synthase
HMPREF9243_0741	ENOG4105D9M	gamma-glutamylcysteine synthetase
HMPREF9243_0743	ENOG4105DQ6	Transposase
HMPREF9243_0744	ENOG4108IJ9	(ABC) transporter
HMPREF9243_0745	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HMPREF9243_0746	ENOG4105DRS	transport system, permease
HMPREF9243_0752	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HMPREF9243_0753	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HMPREF9243_0754	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HMPREF9243_0758	ENOG4108YYH	Nadph-dependent fmn reductase
HMPREF9243_0759	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HMPREF9243_0762	ENOG4105D01	(LipO)protein
HMPREF9243_0770	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
HMPREF9243_0771	ENOG4105EDE	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity)
HMPREF9243_0775	ENOG4108UZ3	Transporter
HMPREF9243_0778	ENOG4105D7W	serine acetyltransferase
HMPREF9243_0779	ENOG4105C6T	cysteine synthase
HMPREF9243_0780	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HMPREF9243_0784	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HMPREF9243_0794	ENOG4107SKW	Inherit from COG: Alpha beta hydrolase
HMPREF9243_0795	ENOG4108R96	Methyltransferase, YaeB family
HMPREF9243_0799	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HMPREF9243_0806	ENOG4105C98	muts2 protein
HMPREF9243_0807	ENOG4105K63	Thioredoxin
HMPREF9243_0809	ENOG4108Z5K	methylglyoxal synthase
HMPREF9243_0810	ENOG4105D6U	Sodium Glutamate Symporter
HMPREF9243_0813	ENOG4105M59	Phosphodiesterase, mj0936 family
HMPREF9243_0814	ENOG4105D8X	mechanosensitive ion channel
HMPREF9243_0818	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HMPREF9243_0819	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HMPREF9243_0820	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HMPREF9243_0824	ENOG4107WUB	V-type ATPase 116 kDa subunit
HMPREF9243_0834	ENOG4105DC7	peptidase M24
HMPREF9243_0835	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HMPREF9243_0837	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HMPREF9243_0838	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HMPREF9243_0839	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HMPREF9243_0840	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HMPREF9243_0842	ENOG4105DX0	Hemolysin A
HMPREF9243_0843	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HMPREF9243_0844	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HMPREF9243_0845	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HMPREF9243_0847	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HMPREF9243_0852	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0854	ENOG4105DQ6	Transposase
HMPREF9243_0856	ENOG4108KGH	TRANSCRIPTIONal
HMPREF9243_0857	ENOG4105HTX	biosynthesis protein
HMPREF9243_0858	ENOG4108QV3	biosynthesis protein
HMPREF9243_0859	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
HMPREF9243_0861	ENOG4105D3Q	Sugar transferase
HMPREF9243_0862	ENOG4105CMR	udp-glucose 4-epimerase
HMPREF9243_0863	ENOG4108PQP	glycosyl transferase group 1
HMPREF9243_0873	ENOG4105PSV	Polysaccharide Biosynthesis Protein
HMPREF9243_0889	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HMPREF9243_0890	ENOG4105CSR	polyphosphate kinase 2
HMPREF9243_0891	ENOG41067QW	Transcriptional regulator
HMPREF9243_0893	ENOG4105CD8	aminopeptidase N
HMPREF9243_0898	ENOG410667J	hydrolase
HMPREF9243_0900	ENOG4108RVA	ribokinase
HMPREF9243_0903	ENOG4107U9T	Pfam:Ribonuclease_BN
HMPREF9243_0905	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HMPREF9243_0909	ENOG4105C9K	Endothelin-converting enzyme 1
HMPREF9243_0911	ENOG4108J59	Extracellular solute-binding protein, family 5
HMPREF9243_0912	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HMPREF9243_0913	ENOG4107QRI	Phosphoketolase
HMPREF9243_0914	ENOG4105C75	arginyL-tRNA synthetase
HMPREF9243_0921	ENOG4105DC8	reductase
HMPREF9243_0924	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HMPREF9243_0925	ENOG4105WT3	Transcriptional regulator
HMPREF9243_0932	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HMPREF9243_0933	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HMPREF9243_0934	ENOG4105C8V	SAICAR synthetase
HMPREF9243_0935	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
HMPREF9243_0936	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HMPREF9243_0937	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HMPREF9243_0938	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HMPREF9243_0939	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HMPREF9243_0940	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HMPREF9243_0943	ENOG4105C83	adenylosuccinate lyase
HMPREF9243_0946	ENOG4105CGZ	zinc metallopeptidase
HMPREF9243_0947	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HMPREF9243_0953	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HMPREF9243_0955	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HMPREF9243_0956	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HMPREF9243_0960	ENOG4105D1H	recombination factor protein RarA
HMPREF9243_0961	ENOG4105C3J	Cysteine desulfurase
HMPREF9243_0963	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HMPREF9243_0964	ENOG4105C7H	Helicase, RecD TraA family
HMPREF9243_0967	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HMPREF9243_0970	ENOG4105VPH	UPF0473 protein
HMPREF9243_0972	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HMPREF9243_0977	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HMPREF9243_0978	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HMPREF9243_0979	ENOG4105EA8	2-Nitropropane dioxygenase
HMPREF9243_0980	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HMPREF9243_0981	ENOG4105CHR	reductase
HMPREF9243_0984	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HMPREF9243_0985	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HMPREF9243_0986	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HMPREF9243_0987	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HMPREF9243_0989	ENOG4105VND	Ribonuclease
HMPREF9243_0993	ENOG4107EFR	Flavocytochrome c
HMPREF9243_0994	ENOG4108K88	Membrane
HMPREF9243_0996	ENOG4105ECY	inositol monophosphatase
HMPREF9243_0997	ENOG4105IW1	AmiS UreI transporter
HMPREF9243_0998	ENOG4105DQ6	Transposase
HMPREF9243_1001	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HMPREF9243_1003	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
HMPREF9243_1006	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HMPREF9243_1007	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HMPREF9243_1011	ENOG4105ETD	TRANSCRIPTIONal
HMPREF9243_1013	ENOG4108YRF	PTS System
HMPREF9243_1014	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HMPREF9243_1015	ENOG4105DM4	PTS System
HMPREF9243_1016	ENOG4105UP7	3-epimerase
HMPREF9243_1018	ENOG4105CUT	histidyl-tRNA synthetase
HMPREF9243_1019	ENOG4105C9M	aspartyl-trna synthetase
HMPREF9243_1023	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HMPREF9243_1024	ENOG4105N80	Ferric uptake regulator, Fur family
HMPREF9243_1025	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
HMPREF9243_1026	ENOG4105DIH	basic membrane
HMPREF9243_1027	ENOG4108JQ9	ABC transporter
HMPREF9243_1033	ENOG4105KTH	gatB Yqey
HMPREF9243_1034	ENOG4105C9A	Phoh family
HMPREF9243_1035	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HMPREF9243_1037	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HMPREF9243_1038	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
HMPREF9243_1040	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HMPREF9243_1048	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HMPREF9243_1049	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HMPREF9243_1050	ENOG4105F23	Fibronectin-binding protein
HMPREF9243_1052	ENOG4108UK2	deaminase
HMPREF9243_1053	ENOG4107R37	Glutamate dehydrogenase
HMPREF9243_1054	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HMPREF9243_1055	ENOG4108Z66	YbaK ebsC protein
HMPREF9243_1056	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HMPREF9243_1057	ENOG4105CSM	endonuclease III
HMPREF9243_1061	ENOG4105CBD	Diacylglycerol kinase
HMPREF9243_1062	ENOG4105FF5	Membrane
HMPREF9243_1064	ENOG4105CI1	PTS System
HMPREF9243_1066	ENOG4105C5X	domain protein
HMPREF9243_1068	ENOG4105WD1	Membrane
HMPREF9243_1069	ENOG4105FGM	Fructosamine kinase
HMPREF9243_1070	ENOG4108HCJ	Hydrolase
HMPREF9243_1074	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HMPREF9243_1087	ENOG4108JJ8	(ABC) transporter
HMPREF9243_1089	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF9243_1092	ENOG4105CY2	Citrate transporter
HMPREF9243_1094	ENOG4108Q3X	Transcriptional regulator
HMPREF9243_1095	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HMPREF9243_1096	ENOG4105C7J	ABC transporter, permease
HMPREF9243_1099	ENOG4106F1P	AAA ATPase, central domain protein
HMPREF9243_1100	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HMPREF9243_1101	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HMPREF9243_1102	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HMPREF9243_1103	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
HMPREF9243_1104	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HMPREF9243_1105	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HMPREF9243_1106	ENOG4105C79	DNA protecting protein DprA
HMPREF9243_1107	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HMPREF9243_1108	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HMPREF9243_1109	ENOG4105C3F	Signal peptidase i
HMPREF9243_1111	ENOG4106E6V	UPF0346 protein
HMPREF9243_1113	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HMPREF9243_1114	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HMPREF9243_1115	ENOG4105C5H	ABC transporter
HMPREF9243_1116	ENOG4105CKU	formyltetrahydrofolate synthetase
HMPREF9243_1119	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
HMPREF9243_1121	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HMPREF9243_1123	ENOG4105DQ6	Transposase
HMPREF9243_1125	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HMPREF9243_1126	ENOG4105CFG	Acts as a chaperone (By similarity)
HMPREF9243_1128	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HMPREF9243_1129	ENOG4105DTN	riboflavin biosynthesis protein ribF
HMPREF9243_1131	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HMPREF9243_1134	ENOG4105C7J	ABC transporter, permease
HMPREF9243_1136	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HMPREF9243_1139	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HMPREF9243_1140	ENOG4105CHV	Transcription elongation factor NusA
HMPREF9243_1141	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HMPREF9243_1145	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HMPREF9243_1146	ENOG4105DZP	Membrane-associated zinc metalloprotease
HMPREF9243_1149	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HMPREF9243_1150	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HMPREF9243_1151	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HMPREF9243_1152	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HMPREF9243_1153	ENOG4105CE9	30S ribosomal protein S2
HMPREF9243_1160	ENOG4105CHU	acetyl-coa acetyltransferase
HMPREF9243_1161	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
HMPREF9243_1162	ENOG4105CY2	Citrate transporter
HMPREF9243_1163	ENOG4105CHR	reductase
HMPREF9243_1169	ENOG4105E39	Enoyl-CoA hydratase
HMPREF9243_1170	ENOG4105C5R	Aminotransferase
HMPREF9243_1171	ENOG4105KMT	branched-chain amino acid
HMPREF9243_1172	ENOG4108UMN	azlc family
HMPREF9243_1173	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HMPREF9243_1177	ENOG4105F6E	Acyl-transferase
HMPREF9243_1178	ENOG4105VXM	UPF0154 protein
HMPREF9243_1179	ENOG4105C34	Pseudouridine synthase
HMPREF9243_1180	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HMPREF9243_1183	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HMPREF9243_1185	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HMPREF9243_1192	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HMPREF9243_1194	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HMPREF9243_1199	ENOG4105EPR	degv family
HMPREF9243_1203	ENOG4105BZ1	(ABC) transporter
HMPREF9243_1206	ENOG4105K46	50S ribosomal protein l27
HMPREF9243_1213	ENOG4105CD3	dihydroorotase
HMPREF9243_1214	ENOG4105CXT	aspartate transcarbamylase
HMPREF9243_1216	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HMPREF9243_1218	ENOG4105CDA	abc transporter atp-binding protein
HMPREF9243_1219	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_1224	ENOG4105CFH	Aspartokinase
HMPREF9243_1225	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HMPREF9243_1228	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HMPREF9243_1229	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HMPREF9243_1230	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HMPREF9243_1231	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
HMPREF9243_1237	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HMPREF9243_1238	ENOG410667J	hydrolase
HMPREF9243_1239	ENOG4105KJF	protein tyrosine phosphatase
HMPREF9243_1241	ENOG4105C5H	ABC transporter
HMPREF9243_1243	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_1248	ENOG4105BZ1	(ABC) transporter
HMPREF9243_1249	ENOG4105C02	permease
HMPREF9243_1250	ENOG4105CS9	pantothenic acid kinase
HMPREF9243_1252	ENOG4105W8X	HesB YadR YfhF-family protein
HMPREF9243_1257	ENOG4108UT2	hemolysin iii
HMPREF9243_1259	ENOG4105CN5	Metallo-Beta-Lactamase
HMPREF9243_1261	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HMPREF9243_1262	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HMPREF9243_1263	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HMPREF9243_1265	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HMPREF9243_1266	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HMPREF9243_1268	ENOG4105F1K	Glutamine amidotransferase
HMPREF9243_1269	ENOG4105DMS	mur ligase
HMPREF9243_1271	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HMPREF9243_1272	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HMPREF9243_1273	ENOG4105DCF	alanine dehydrogenase
HMPREF9243_1274	ENOG4105DGA	Diaminopimelate dehydrogenase
HMPREF9243_1275	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HMPREF9243_1276	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HMPREF9243_1277	ENOG4107RGD	Major Facilitator superfamily
HMPREF9243_1278	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HMPREF9243_1283	ENOG4106HBX	Transcriptional Regulator AraC Family
HMPREF9243_1284	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HMPREF9243_1285	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HMPREF9243_1289	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HMPREF9243_1291	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HMPREF9243_1294	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HMPREF9243_1295	ENOG4105CP7	Triose-phosphate isomerase
HMPREF9243_1296	ENOG4105BZA	Phosphoglycerate kinase
HMPREF9243_1299	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HMPREF9243_1304	ENOG4105D01	(LipO)protein
HMPREF9243_1309	ENOG4105DM4	PTS System
HMPREF9243_1310	ENOG4105DE4	1-phosphofructokinase
HMPREF9243_1311	ENOG4105E98	transcriptional regulator DeoR family
HMPREF9243_1338	ENOG4107QYV	phosphohexose isomerase
HMPREF9243_1340	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HMPREF9243_1342	ENOG4105CAY	ferredoxin--nadp reductase
HMPREF9243_1350	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HMPREF9243_1352	ENOG4105K70	DNA-binding protein
HMPREF9243_1353	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HMPREF9243_1354	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HMPREF9243_1355	ENOG4105CAT	Cytidine monophosphate kinase
HMPREF9243_1357	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HMPREF9243_1361	ENOG4108SAX	Membrane
HMPREF9243_1363	ENOG4105FE9	pseudouridine synthase
HMPREF9243_1364	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HMPREF9243_1371	ENOG4105QNR	S1 RNA binding domain protein
HMPREF9243_1372	ENOG4105CA9	Pyruvate kinase
HMPREF9243_1373	ENOG4105CTQ	phosphohexokinase
HMPREF9243_1374	ENOG4105C0B	DNA polymerase III (alpha subunit)
HMPREF9243_1376	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HMPREF9243_1377	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HMPREF9243_1379	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HMPREF9243_1380	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HMPREF9243_1381	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HMPREF9243_1386	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HMPREF9243_1387	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HMPREF9243_1388	ENOG4105CEV	competence damage-inducible protein
HMPREF9243_1389	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HMPREF9243_1391	ENOG410855V	Acylphosphatase
HMPREF9243_1392	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
HMPREF9243_1393	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HMPREF9243_1394	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HMPREF9243_1397	ENOG4105C3J	Cysteine desulfurase
HMPREF9243_1398	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
HMPREF9243_1400	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HMPREF9243_1404	ENOG4105DQ6	Transposase
HMPREF9243_1406	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HMPREF9243_1408	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HMPREF9243_1411	ENOG4105DBK	s4 domain protein
HMPREF9243_1412	ENOG41067XK	integral membrane protein
HMPREF9243_1413	ENOG4105DFA	alanine racemase domain protein
HMPREF9243_1416	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
HMPREF9243_1417	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HMPREF9243_1420	ENOG4105CJN	penicillin-binding protein
HMPREF9243_1426	ENOG41067VY	50S ribosomal protein L32
HMPREF9243_1428	ENOG4105CDE	UPF0348 protein
HMPREF9243_1429	ENOG4105DXX	methyltransferase
HMPREF9243_1430	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HMPREF9243_1431	ENOG4108WF2	Metal Dependent Phosphohydrolase
HMPREF9243_1432	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HMPREF9243_1433	ENOG410812S	Rna-binding protein
HMPREF9243_1434	ENOG4105CQW	ribosome biogenesis GTPase YqeH
HMPREF9243_1435	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HMPREF9243_1436	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HMPREF9243_1437	ENOG4105D6E	homoserine dehydrogenase
HMPREF9243_1438	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HMPREF9243_1440	ENOG4105BZF	Glycosyl transferase (Group 1
HMPREF9243_1441	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HMPREF9243_1442	ENOG4105KRI	phosphocarrier protein (HPr
HMPREF9243_1443	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HMPREF9243_1445	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HMPREF9243_1446	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HMPREF9243_1448	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_1449	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HMPREF9243_1458	ENOG41082BV	acetyltransferase
HMPREF9243_1462	ENOG4105CJW	magnesium transporter
HMPREF9243_1463	ENOG4105EMS	pseudouridine synthase
HMPREF9243_1465	ENOG4105MIX	Adenylate cyclase
HMPREF9243_1470	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HMPREF9243_1473	ENOG4105D01	(LipO)protein
HMPREF9243_1474	ENOG4108UMI	ABC transporter, permease
HMPREF9243_1475	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HMPREF9243_1476	ENOG4105HUF	DNA protection during starvation protein
HMPREF9243_1477	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HMPREF9243_1478	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HMPREF9243_1480	ENOG4105CH2	amidohydrolase
HMPREF9243_1481	ENOG4108UVJ	appr-1-p processing domain protein
HMPREF9243_1483	ENOG4105C22	threonyL-tRNA synthetase
HMPREF9243_1488	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HMPREF9243_1492	ENOG4105C2M	dna polymerase I
HMPREF9243_1499	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HMPREF9243_1501	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HMPREF9243_1502	ENOG4108VX5	3-methyladenine DNA glycosylase
HMPREF9243_1503	ENOG4105WZW	rhodanese family
HMPREF9243_1505	ENOG4107ZXI	Rhomboid family
HMPREF9243_1507	ENOG4107RF6	penicillin-binding protein
HMPREF9243_1509	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HMPREF9243_1512	ENOG4105C1J	atp-dependent rna helicase
HMPREF9243_1513	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HMPREF9243_1514	ENOG4105SFS	phosphoesterase RecJ domain protein
HMPREF9243_1519	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HMPREF9243_1520	ENOG4105DQ6	Transposase
HMPREF9243_1522	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HMPREF9243_1523	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HMPREF9243_1525	ENOG4107QKR	Dehydrogenase
HMPREF9243_1527	ENOG4107RUY	(E1 component), alpha subunit
HMPREF9243_1528	ENOG4107QN2	dihydrolipoyl dehydrogenase
HMPREF9243_1529	ENOG4105DND	Transcriptional regulator
HMPREF9243_1532	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HMPREF9243_1533	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HMPREF9243_1534	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HMPREF9243_1535	ENOG4105VB6	UPF0109 protein
HMPREF9243_1536	ENOG4105K5M	30s ribosomal protein S16
HMPREF9243_1541	ENOG4105BZ1	(ABC) transporter
HMPREF9243_1545	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
HMPREF9243_1546	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HMPREF9243_1547	ENOG410667J	hydrolase
HMPREF9243_1548	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HMPREF9243_1550	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HMPREF9243_1551	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HMPREF9243_1552	ENOG4105CB5	ATP-dependent DNA helicase recG
HMPREF9243_1554	ENOG4105DP4	dak2 domain fusion protein ylov
HMPREF9243_1555	ENOG4108ZAA	Alkaline-shock protein
HMPREF9243_1557	ENOG4105DJV	ribulose-phosphate 3-epimerase
HMPREF9243_1558	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HMPREF9243_1559	ENOG4105D9P	serine threonine protein kinase
HMPREF9243_1561	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HMPREF9243_1562	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HMPREF9243_1564	ENOG4105C25	Primosomal protein n'
HMPREF9243_1565	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HMPREF9243_1569	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HMPREF9243_1572	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HMPREF9243_1573	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HMPREF9243_1574	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HMPREF9243_1575	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HMPREF9243_1576	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HMPREF9243_1577	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HMPREF9243_1580	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HMPREF9243_1581	ENOG4105KQC	Competence protein
HMPREF9243_1582	ENOG4106H78	methyltransferase
HMPREF9243_1585	ENOG4105WUC	UPF0298 protein
HMPREF9243_1586	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HMPREF9243_1587	ENOG4105CNI	cell division protein FtsW
HMPREF9243_1589	ENOG4105CI3	gtp-binding protein typa
HMPREF9243_1590	ENOG4105ECY	inositol monophosphatase
HMPREF9243_1591	ENOG4105WBI	UPF0223 protein
HMPREF9243_1593	ENOG4105DRP	amino acid AbC transporter
HMPREF9243_1594	ENOG4105EAD	ABC transporter
HMPREF9243_1595	ENOG4105CT1	(ABC) transporter
HMPREF9243_1599	ENOG4105DQ6	Transposase
HMPREF9243_1601	ENOG4105C7S	Dehydrogenase
HMPREF9243_1604	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HMPREF9243_1605	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HMPREF9243_1606	ENOG4107QID	Threonine synthase
HMPREF9243_1607	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HMPREF9243_1608	ENOG4105HMI	Membrane
HMPREF9243_1609	ENOG4108MR7	Arylsulfotransferase
HMPREF9243_1610	ENOG4105K63	Thioredoxin
HMPREF9243_1618	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HMPREF9243_1619	ENOG4108JQ7	(ABC) transporter
HMPREF9243_1621	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HMPREF9243_1622	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HMPREF9243_1628	ENOG4107QSE	Dipeptidase
HMPREF9243_1631	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HMPREF9243_1632	ENOG4105KJF	protein tyrosine phosphatase
HMPREF9243_1633	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HMPREF9243_1634	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HMPREF9243_1640	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HMPREF9243_1641	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HMPREF9243_1644	ENOG4108QV3	biosynthesis protein
HMPREF9243_1645	ENOG4105HTX	biosynthesis protein
HMPREF9243_1647	ENOG4108Z4K	mutator MutT protein
HMPREF9243_1648	ENOG4105EPR	degv family
HMPREF9243_1651	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HMPREF9243_1652	ENOG4108KGH	TRANSCRIPTIONal
HMPREF9243_1655	ENOG4105NQC	Flavodoxin
HMPREF9243_1657	ENOG4107QSI	ABC, transporter
HMPREF9243_1659	ENOG4107SJB	teichoic acid biosynthesis
HMPREF9243_1661	ENOG4105K64	Glycosyl transferase, family 2
HMPREF9243_1662	ENOG4108RYC	glycosyltransferase
HMPREF9243_1663	ENOG4105K64	Glycosyl transferase, family 2
HMPREF9243_1665	ENOG4105D2T	synthase
HMPREF9243_1671	ENOG4107T94	Endo-14-beta-xylanase
HMPREF9243_1675	ENOG4105DFT	pur operon repressor
HMPREF9243_1677	ENOG4105FDK	ABC transporter
HMPREF9243_1678	ENOG4105DSE	periplasmic solute binding protein
HMPREF9243_1679	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HMPREF9243_1680	ENOG4105W42	Veg protein
HMPREF9243_1683	ENOG4108IUW	ABC transporter
HMPREF9243_1684	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HMPREF9243_1686	ENOG4105F8V	Hydrolase, tatD family
HMPREF9243_1687	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HMPREF9243_1690	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HMPREF9243_1694	ENOG4105C5F	glutamine synthetase
HMPREF9243_1699	ENOG4105CHM	Aminotransferase
HMPREF9243_1700	ENOG4108ZB6	transcriptional regulator AsnC family
HMPREF9243_1702	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HMPREF9243_1703	ENOG4105C0H	protease
HMPREF9243_1704	ENOG4105Q2H	domain protein
HMPREF9243_1708	ENOG4105BZU	Histidine kinase
HMPREF9243_1709	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HMPREF9243_1715	ENOG4105VKD	bioY protein
HMPREF9243_1717	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HMPREF9243_1718	ENOG410667J	hydrolase
HMPREF9243_1722	ENOG4105DU0	nucleoside hydrolase
HMPREF9243_1723	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HMPREF9243_1724	ENOG4107UWA	esterase
HMPREF9243_1726	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HMPREF9243_1727	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HMPREF9243_1729	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HMPREF9243_1730	ENOG4105DVK	Precorrin-2 c20-methyltransferase
HMPREF9243_1731	ENOG4107PPM	cobalt chelatase
HMPREF9243_1733	ENOG4108JTQ	reductase
HMPREF9243_1734	ENOG4105E4R	Precorrin-3B C17-methyltransferase
HMPREF9243_1737	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
HMPREF9243_1738	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
HMPREF9243_1739	ENOG4108DR9	Cobalt-precorrin-6Y C(5)-methyltransferase
HMPREF9243_1740	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
HMPREF9243_1741	ENOG41081F0	Precorrin-8x methylmutase
HMPREF9243_1742	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HMPREF9243_1746	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HMPREF9243_1747	ENOG4107QZB	decarboxylase
HMPREF9243_1749	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HMPREF9243_1750	ENOG4108YZT	Adenosylcobinamide kinase
HMPREF9243_1753	ENOG4105SYT	Methylenetetrahydrofolate reductase
HMPREF9243_1754	ENOG4105C5B	carbamate kinase
HMPREF9243_1757	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HMPREF9243_1759	ENOG4105DBV	ornithine carbamoyltransferase
HMPREF9243_1761	ENOG41075H3	AraC family transcriptional regulator
HMPREF9243_1763	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
HMPREF9243_1764	ENOG4105DVM	PP-loop domain protein
HMPREF9243_1769	ENOG4105CHF	Glutathione S-transferase
HMPREF9243_1771	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HMPREF9243_1775	ENOG4105DF9	Lipoate-protein, ligase
HMPREF9243_1777	ENOG4105DSE	periplasmic solute binding protein
HMPREF9243_1778	ENOG4105CNT	hydrolase family 2
HMPREF9243_1779	ENOG4105DPH	UPF0371 protein
HMPREF9243_1784	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HMPREF9243_1785	ENOG4105E2Z	phosphate ABC transporter (Permease
HMPREF9243_1786	ENOG4105C8U	phosphate abc transporter
HMPREF9243_1787	ENOG4107S17	Phosphate-binding protein
HMPREF9243_1788	ENOG4105BZU	Histidine kinase
HMPREF9243_1789	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HMPREF9243_1791	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HMPREF9243_1793	ENOG41081UC	Inherit from COG: Competence protein
HMPREF9243_1795	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HMPREF9243_1796	ENOG4105DQ6	Transposase
HMPREF9243_1798	ENOG4108UHU	Aldolase
HMPREF9243_1799	ENOG4105ZMH	deoxynucleoside kinase
HMPREF9243_1801	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HMPREF9243_1802	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HMPREF9243_1806	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HMPREF9243_1808	ENOG4105ETD	TRANSCRIPTIONal
HMPREF9243_1809	ENOG4105CTS	PTS system mannitol-specific
HMPREF9243_1810	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HMPREF9243_1811	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9243_1812	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_1813	ENOG4105CH7	arginosuccinase
HMPREF9243_1814	ENOG4105E5Q	amino acid AbC transporter
HMPREF9243_1816	ENOG4105C26	Dehydrogenase
HMPREF9243_1817	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HMPREF9243_1818	ENOG4105DYB	Isoaspartyl dipeptidase
HMPREF9243_1820	ENOG4105C83	adenylosuccinate lyase
HMPREF9243_1822	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HMPREF9243_1824	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HMPREF9243_1825	ENOG4105C5H	ABC transporter
HMPREF9243_1827	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HMPREF9243_1828	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HMPREF9243_1830	ENOG41072GX	Peptidase M22 Glycoprotease
HMPREF9243_1831	ENOG4105VPS	UPF0291 protein
HMPREF9243_1834	ENOG4105CGK	Exodeoxyribonuclease III
HMPREF9243_1837	ENOG4105DQ6	Transposase
HMPREF9243_1838	ENOG4105C5I	Dehydrogenase
HMPREF9243_1840	ENOG4105CHF	Glutathione S-transferase
HMPREF9243_1854	ENOG4105CMR	udp-glucose 4-epimerase
HMPREF9243_1857	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HMPREF9243_1858	ENOG4108UQV	Membrane
HMPREF9243_1860	ENOG4105KWG	Pfam:DUF1696
HMPREF9243_1865	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HMPREF9243_1866	ENOG4105C72	UPF0176 protein
HMPREF9243_1878	ENOG4105EWM	Histidine kinase
HMPREF9243_1879	ENOG4105CJZ	response regulator
HMPREF9243_1883	ENOG4107TXC	Transcriptional regulator
HMPREF9243_1887	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HMPREF9243_1889	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HMPREF9243_1890	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HMPREF9243_1896	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HMPREF9243_1897	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HMPREF9243_1911	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HMPREF9243_1913	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HMPREF9243_1914	ENOG4108IG5	Transcriptional regulator
HMPREF9243_1917	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HMPREF9243_1924	ENOG4105CJ1	ABC, transporter
HMPREF9243_1926	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HMPREF9243_1938	ENOG4105BZ1	(ABC) transporter
HMPREF9243_1939	ENOG4108JJB	ABC transporter
HMPREF9243_1941	ENOG4108Z6Z	Transcriptional regulator
HMPREF9243_1944	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HMPREF9243_1947	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HMPREF9243_1948	ENOG4105CQ4	Transcriptional regulator
HMPREF9243_1949	ENOG4105CGH	5'-nucleotidase
HMPREF9243_1952	ENOG4105D5T	phosphonate abc transporter
HMPREF9243_1954	ENOG4108M1Z	surface protein
HMPREF9243_1955	ENOG4105DQ6	Transposase
HMPREF9243_1957	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HMPREF9243_1958	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HMPREF9243_1959	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HMPREF9243_1961	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HMPREF9243_1962	ENOG4105C4R	Atp-dependent dna helicase
HMPREF9243_1964	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HMPREF9243_1966	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HMPREF9243_1971	ENOG4108IV0	ABC, transporter
HMPREF9243_1972	ENOG4105C0Z	ABC transporter
HMPREF9243_1973	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HMPREF9243_1974	ENOG4105C32	Amino acid ABC transporter (Permease)
HMPREF9243_1979	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HMPREF9243_1980	ENOG4108HCJ	Hydrolase
HMPREF9243_1981	ENOG4105CTP	PilT protein domain protein
HMPREF9243_1982	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HMPREF9243_1983	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HMPREF9243_1989	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HMPREF9243_1991	ENOG4105C3G	gtp-binding protein
HMPREF9243_1992	ENOG4105VDK	protein, conserved in bacteria
HMPREF9243_1993	ENOG4105FA0	parb-like partition protein
HMPREF9243_1994	ENOG4107QJE	Chromosome Partitioning Protein
HMPREF9243_1996	ENOG4105CIG	ABC transporter
HMPREF9243_1998	ENOG4108TV1	Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity)
HMPREF9243_2002	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HMPREF9243_2005	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HMPREF9243_2006	ENOG4108HRK	Histidine kinase
HMPREF9243_2007	ENOG4105DY9	regulatoR
HMPREF9243_2009	ENOG41067MG	lrgb family
HMPREF9243_2010	ENOG4107SHS	Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity)
HMPREF9243_2017	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HMPREF9243_2018	ENOG4108JQ5	ABC transporter
HMPREF9243_2020	ENOG4105DQ6	Transposase
HMPREF9243_2021	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HMPREF9243_2023	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HMPREF9243_2024	ENOG4108JJB	ABC transporter
HMPREF9243_2025	ENOG4108V4M	Cobalt abc transporter
HMPREF9243_2027	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
HMPREF9243_2029	ENOG4108JU6	CBS domain protein
HMPREF9243_2030	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HMPREF9243_2031	ENOG4105C59	p-type ATPase
HMPREF9243_2032	ENOG4105C02	permease
HMPREF9243_2033	ENOG4105K8R	UPF0145 protein
HMPREF9243_2037	ENOG4105F3R	pts system mannose fructose sorbose family iid
HMPREF9243_2038	ENOG4105ETZ	PTS System
HMPREF9243_2041	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HMPREF9243_2042	ENOG4105C1G	acyl-Coa dehydrogenase
HMPREF9243_2043	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HMPREF9243_2044	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
HMPREF9243_2045	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMPREF9243_2046	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HMPREF9243_2047	ENOG4105VG0	50S ribosomal protein l34
HMPREF9243_2051	ENOG4105CPP	Dehydrogenase, E1 component
HMPREF9243_2052	ENOG4105C7S	Dehydrogenase
HMPREF9243_2058	ENOG41067V7	50S ribosomal protein L36