locus-tag	class	description
HMPREF9243_0002	COG0592	DNA-directed DNA polymerase activity
HMPREF9243_0004	COG0277	FAD linked oxidase domain protein
HMPREF9243_0005	COG2501	S4 domain
HMPREF9243_0006	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9243_0007	COG0187	DNA topoisomerase II activity
HMPREF9243_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9243_0009	COG4152	abc transporter atp-binding protein
HMPREF9243_0010	COG1668	transmembrane transport
HMPREF9243_0014	COG1288	antiporter activity
HMPREF9243_0015	COG1473	amidohydrolase
HMPREF9243_0016	COG0360	Binds together with S18 to 16S ribosomal RNA
HMPREF9243_0017	COG0629	single-stranded DNA binding
HMPREF9243_0018	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF9243_0022	COG4619	ABC transporter
HMPREF9243_0023	COG0390	transport system, permease component
HMPREF9243_0024	COG0390	transport system, permease component
HMPREF9243_0025	COG0359	binds to the 23S rRNA
HMPREF9243_0026	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9243_0028	COG1454	alcohol dehydrogenase
HMPREF9243_0032	COG0133	tryptophan synthase activity
HMPREF9243_0037	COG1335	isochorismatase
HMPREF9243_0044	COG2801	Transposase and inactivated derivatives
HMPREF9243_0045	COG1473	amidohydrolase
HMPREF9243_0054	COG0626	cystathionine gamma-synthase activity
HMPREF9243_0058	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMPREF9243_0059	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9243_0066	COG0157	Belongs to the NadC ModD family
HMPREF9243_0070	COG2801	Transposase and inactivated derivatives
HMPREF9243_0074	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9243_0074	COG0351	phosphomethylpyrimidine kinase
HMPREF9243_0076	COG1454	alcohol dehydrogenase
HMPREF9243_0076	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9243_0080	COG2801	Transposase and inactivated derivatives
HMPREF9243_0082	COG0438	transferase activity, transferring glycosyl groups
HMPREF9243_0088	COG3279	Response regulator of the LytR AlgR family
HMPREF9243_0091	COG0402	S-adenosylhomocysteine deaminase activity
HMPREF9243_0092	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF9243_0094	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF9243_0096	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9243_0097	COG2217	Heavy metal translocating P-type atpase
HMPREF9243_0100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF9243_0101	COG0789	Transcriptional regulator
HMPREF9243_0102	COG1053	succinate dehydrogenase
HMPREF9243_0105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HMPREF9243_0106	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9243_0108	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF9243_0109	COG1309	transcriptional regulator
HMPREF9243_0110	COG1136	(ABC) transporter
HMPREF9243_0113	COG0778	Nitroreductase
HMPREF9243_0115	COG3118	belongs to the thioredoxin family
HMPREF9243_0116	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9243_0117	COG0583	DNA-binding transcription factor activity
HMPREF9243_0118	COG1024	Enoyl-CoA hydratase
HMPREF9243_0121	COG0583	DNA-binding transcription factor activity
HMPREF9243_0122	COG0656	L-ascorbic acid biosynthetic process
HMPREF9243_0129	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9243_0130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9243_0131	COG2011	ABC-type metal ion transport system permease component
HMPREF9243_0138	COG1484	DNA-dependent DNA replication
HMPREF9243_0175	COG1619	proteins homologs of microcin C7 resistance protein MccF
HMPREF9243_0192	COG4115	mRNA cleavage
HMPREF9243_0201	COG1373	ATPase (AAA superfamily
HMPREF9243_0208	COG2801	Transposase and inactivated derivatives
HMPREF9243_0218	COG3976	FMN-binding domain protein
HMPREF9243_0218	COG1053	succinate dehydrogenase
HMPREF9243_0218	COG0431	NADPH-dependent FMN reductase
HMPREF9243_0219	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9243_0220	COG1053	succinate dehydrogenase
HMPREF9243_0220	COG3976	FMN-binding domain protein
HMPREF9243_0220	COG0431	NADPH-dependent FMN reductase
HMPREF9243_0221	COG0583	DNA-binding transcription factor activity
HMPREF9243_0222	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9243_0223	COG0738	Major facilitator superfamily
HMPREF9243_0224	COG0710	3-dehydroquinate dehydratase activity
HMPREF9243_0225	COG2851	Citrate transporter
HMPREF9243_0231	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9243_0231	COG1263	PTS System
HMPREF9243_0233	COG3290	protein histidine kinase activity
HMPREF9243_0234	COG4565	transcriptional regulatory protein
HMPREF9243_0236	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF9243_0237	COG2390	Transcriptional regulator
HMPREF9243_0238	COG1737	Transcriptional regulator
HMPREF9243_0239	COG1482	cell wall glycoprotein biosynthetic process
HMPREF9243_0240	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HMPREF9243_0241	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HMPREF9243_0242	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_0242	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_0242	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_0245	COG1011	Hydrolase
HMPREF9243_0246	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_0246	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_0246	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_0247	COG1482	cell wall glycoprotein biosynthetic process
HMPREF9243_0250	COG3775	system Galactitol-specific IIC component
HMPREF9243_0258	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_0259	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9243_0265	COG2801	Transposase and inactivated derivatives
HMPREF9243_0269	COG2022	thiamine diphosphate biosynthetic process
HMPREF9243_0272	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF9243_0275	COG0800	Aldolase
HMPREF9243_0278	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HMPREF9243_0280	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF9243_0283	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF9243_0285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9243_0288	COG2801	Transposase and inactivated derivatives
HMPREF9243_0291	COG2723	6-phospho-beta-galactosidase activity
HMPREF9243_0294	COG3711	transcriptional antiterminator
HMPREF9243_0294	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_0295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF9243_0298	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF9243_0300	COG1178	ABC-type Fe3 transport system permease component
HMPREF9243_0303	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9243_0307	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_0308	COG3730	PTS system glucitol sorbitol-specific
HMPREF9243_0309	COG3732	PTS system glucitol sorbitol-specific
HMPREF9243_0311	COG0693	protein deglycase activity
HMPREF9243_0314	COG2070	2-Nitropropane dioxygenase
HMPREF9243_0316	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HMPREF9243_0317	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMPREF9243_0319	COG1942	4-Oxalocrotonate Tautomerase
HMPREF9243_0324	COG2865	translation initiation factor activity
HMPREF9243_0335	COG2801	Transposase and inactivated derivatives
HMPREF9243_0337	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF9243_0339	COG0419	ATPase involved in DNA repair
HMPREF9243_0342	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMPREF9243_0343	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF9243_0344	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF9243_0346	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9243_0351	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9243_0353	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF9243_0354	COG1481	regulation of sporulation
HMPREF9243_0355	COG3976	FMN-binding domain protein
HMPREF9243_0355	COG1053	succinate dehydrogenase
HMPREF9243_0356	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9243_0358	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_0359	COG5002	protein histidine kinase activity
HMPREF9243_0359	COG3850	Histidine kinase
HMPREF9243_0362	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMPREF9243_0363	COG2801	Transposase and inactivated derivatives
HMPREF9243_0367	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9243_0370	COG3022	response to hydroperoxide
HMPREF9243_0371	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9243_0371	COG2190	(PTS) system
HMPREF9243_0371	COG1263	PTS System
HMPREF9243_0372	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9243_0373	COG3189	MarR family transcriptional regulator
HMPREF9243_0376	COG0366	Alpha amylase catalytic
HMPREF9243_0377	COG0561	phosphatase activity
HMPREF9243_0380	COG1187	pseudouridine synthase activity
HMPREF9243_0383	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF9243_0384	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPREF9243_0386	COG0215	cysteine-tRNA ligase activity
HMPREF9243_0387	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF9243_0388	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF9243_0389	COG3688	RNA-binding protein containing a PIN domain
HMPREF9243_0391	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9243_0392	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF9243_0394	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF9243_0395	COG0081	regulation of translation
HMPREF9243_0397	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF9243_0399	COG1609	Transcriptional regulator
HMPREF9243_0400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9243_0402	COG2813	Specifically methylates the guanine in position
HMPREF9243_0404	COG2801	Transposase and inactivated derivatives
HMPREF9243_0405	COG3448	diguanylate cyclase activity
HMPREF9243_0405	COG4175	Glycine betaine
HMPREF9243_0410	COG2848	UPF0210 protein
HMPREF9243_0411	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9243_0412	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF9243_0414	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF9243_0416	COG2096	Adenosyltransferase
HMPREF9243_0426	COG1131	(ABC) transporter
HMPREF9243_0428	COG1230	cation diffusion facilitator family transporter
HMPREF9243_0429	COG4463	regulation of RNA biosynthetic process
HMPREF9243_0430	COG0542	response to heat
HMPREF9243_0432	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMPREF9243_0433	COG0590	tRNA wobble adenosine to inosine editing
HMPREF9243_0435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF9243_0436	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMPREF9243_0437	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF9243_0438	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMPREF9243_0439	COG0470	DNA polymerase III
HMPREF9243_0441	COG4467	Involved in initiation control of chromosome replication
HMPREF9243_0442	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPREF9243_0444	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMPREF9243_0446	COG1970	mechanosensitive ion channel activity
HMPREF9243_0447	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF9243_0449	COG0436	Aminotransferase
HMPREF9243_0450	COG1078	dGTPase activity
HMPREF9243_0454	COG3343	RNA polymerase activity
HMPREF9243_0455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9243_0456	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HMPREF9243_0457	COG0254	rRNA binding
HMPREF9243_0458	COG3764	Sortase (surface protein transpeptidase)
HMPREF9243_0461	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9243_0462	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9243_0464	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF9243_0465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HMPREF9243_0469	COG0789	Transcriptional regulator
HMPREF9243_0471	COG1131	(ABC) transporter
HMPREF9243_0473	COG1253	flavin adenine dinucleotide binding
HMPREF9243_0477	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HMPREF9243_0478	COG0463	Glycosyl transferase, family 2
HMPREF9243_0487	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF9243_0488	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF9243_0489	COG0193	aminoacyl-tRNA hydrolase activity
HMPREF9243_0490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMPREF9243_0491	COG2244	polysaccharide biosynthetic process
HMPREF9243_0492	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPREF9243_0494	COG1098	S1 RNA binding domain
HMPREF9243_0495	COG0037	tRNA processing
HMPREF9243_0497	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9243_0498	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMPREF9243_0500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMPREF9243_0501	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF9243_0503	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMPREF9243_0504	COG0049	tRNA binding
HMPREF9243_0505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF9243_0506	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF9243_0508	COG0051	transcription antitermination factor activity, RNA binding
HMPREF9243_0509	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMPREF9243_0511	COG0089	rRNA binding
HMPREF9243_0512	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF9243_0513	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF9243_0516	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMPREF9243_0517	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF9243_0518	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF9243_0519	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF9243_0521	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF9243_0522	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF9243_0524	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMPREF9243_0525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF9243_0526	COG1841	ribosomal large subunit assembly
HMPREF9243_0527	COG0200	Binds to the 23S rRNA
HMPREF9243_0530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF9243_0532	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF9243_0533	COG0202	RNA polymerase activity
HMPREF9243_0534	COG0203	ribosomal protein L17
HMPREF9243_0537	COG1122	ATPase activity
HMPREF9243_0538	COG1122	ATPase activity
HMPREF9243_0540	COG0101	tRNA pseudouridine synthase activity
HMPREF9243_0545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF9243_0554	COG1902	pentaerythritol trinitrate reductase activity
HMPREF9243_0555	COG1597	lipid kinase activity
HMPREF9243_0556	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF9243_0562	COG0778	Nitroreductase
HMPREF9243_0563	COG0564	pseudouridine synthase activity
HMPREF9243_0569	COG3639	organic phosphonate transmembrane transporter activity
HMPREF9243_0571	COG0604	alcohol dehydrogenase
HMPREF9243_0572	COG0402	S-adenosylhomocysteine deaminase activity
HMPREF9243_0574	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMPREF9243_0575	COG0668	transmembrane transport
HMPREF9243_0582	COG1134	teichoic acid transport
HMPREF9243_0582	COG1388	LysM domain
HMPREF9243_0583	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF9243_0588	COG2137	regulation of response to DNA damage stimulus
HMPREF9243_0589	COG1194	a g-specific adenine glycosylase
HMPREF9243_0592	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF9243_0593	COG4129	membrane
HMPREF9243_0595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF9243_0611	COG0582	viral genome integration into host DNA
HMPREF9243_0613	COG1396	sequence-specific DNA binding
HMPREF9243_0615	COG2059	Chromate
HMPREF9243_0619	COG2801	Transposase and inactivated derivatives
HMPREF9243_0624	COG1653	transport
HMPREF9243_0626	COG0395	ABC-type sugar transport system, permease component
HMPREF9243_0627	COG3842	ATPase activity
HMPREF9243_0628	COG1653	transport
HMPREF9243_0639	COG0517	IMP dehydrogenase activity
HMPREF9243_0639	COG0516	GMP reductase activity
HMPREF9243_0640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF9243_0641	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF9243_0642	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HMPREF9243_0643	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9243_0644	COG3679	Belongs to the UPF0342 family
HMPREF9243_0646	COG4717	serine-type aminopeptidase activity
HMPREF9243_0647	COG3481	metal-dependent phosphohydrolase, HD sub domain
HMPREF9243_0648	COG1442	glycosyl transferase family 8
HMPREF9243_0651	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF9243_0652	COG1131	(ABC) transporter
HMPREF9243_0655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF9243_0657	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9243_0659	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMPREF9243_0665	COG0495	leucyl-tRNA aminoacylation
HMPREF9243_0667	COG1126	abc transporter atp-binding protein
HMPREF9243_0668	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9243_0669	COG0765	amino acid transport
HMPREF9243_0672	COG2244	polysaccharide biosynthetic process
HMPREF9243_0676	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF9243_0678	COG1733	regulation of RNA biosynthetic process
HMPREF9243_0680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMPREF9243_0681	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9243_0681	COG0072	phenylalanine-tRNA ligase activity
HMPREF9243_0682	COG1115	amino acid carrier protein
HMPREF9243_0683	COG0280	phosphate acetyltransferase
HMPREF9243_0688	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF9243_0689	COG4475	Protein of unknown function (DUF436)
HMPREF9243_0690	COG0802	atpase or kinase
HMPREF9243_0693	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF9243_0694	COG1122	ATPase activity
HMPREF9243_0695	COG0406	alpha-ribazole phosphatase activity
HMPREF9243_0699	COG1116	anion transmembrane transporter activity
HMPREF9243_0699	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF9243_0702	COG3579	cysteine-type endopeptidase activity
HMPREF9243_0703	COG0577	efflux transmembrane transporter activity
HMPREF9243_0704	COG1136	(ABC) transporter
HMPREF9243_0705	COG3949	Membrane
HMPREF9243_0708	COG1609	Transcriptional regulator
HMPREF9243_0710	COG3715	PTS system
HMPREF9243_0716	COG1132	(ABC) transporter
HMPREF9243_0718	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9243_0725	COG0431	NADPH-dependent FMN reductase
HMPREF9243_0725	COG1053	succinate dehydrogenase
HMPREF9243_0725	COG3976	FMN-binding domain protein
HMPREF9243_0729	COG1263	PTS System
HMPREF9243_0729	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9243_0729	COG2190	(PTS) system
HMPREF9243_0734	COG0588	phosphoglycerate mutase activity
HMPREF9243_0735	COG0588	phosphoglycerate mutase activity
HMPREF9243_0736	COG0431	NADPH-dependent FMN reductase
HMPREF9243_0738	COG0028	Belongs to the TPP enzyme family
HMPREF9243_0741	COG2918	glutathione biosynthetic process
HMPREF9243_0741	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9243_0743	COG2801	Transposase and inactivated derivatives
HMPREF9243_0744	COG3842	ATPase activity
HMPREF9243_0745	COG1175	transmembrane transport
HMPREF9243_0746	COG0395	ABC-type sugar transport system, permease component
HMPREF9243_0752	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF9243_0753	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HMPREF9243_0754	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HMPREF9243_0758	COG0431	NADPH-dependent FMN reductase
HMPREF9243_0759	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9243_0762	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9243_0769	COG0653	protein targeting
HMPREF9243_0773	COG1442	glycosyl transferase family 8
HMPREF9243_0774	COG1215	transferase activity, transferring glycosyl groups
HMPREF9243_0778	COG1045	serine acetyltransferase
HMPREF9243_0779	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HMPREF9243_0780	COG1304	FMN binding
HMPREF9243_0784	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMPREF9243_0784	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9243_0794	COG0596	Alpha beta hydrolase
HMPREF9243_0795	COG1720	tRNA m6t6A37 methyltransferase activity
HMPREF9243_0799	COG0577	efflux transmembrane transporter activity
HMPREF9243_0799	COG1136	(ABC) transporter
HMPREF9243_0802	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9243_0802	COG1263	PTS System
HMPREF9243_0806	COG1193	negative regulation of DNA recombination
HMPREF9243_0807	COG3118	belongs to the thioredoxin family
HMPREF9243_0809	COG1803	Methylglyoxal synthase
HMPREF9243_0810	COG0786	glutamate:sodium symporter activity
HMPREF9243_0813	COG0622	Phosphoesterase
HMPREF9243_0814	COG0668	transmembrane transport
HMPREF9243_0816	COG4980	gas vesicle protein
HMPREF9243_0818	COG1394	ATPase activity, coupled to movement of substances
HMPREF9243_0824	COG1269	ATP hydrolysis coupled proton transport
HMPREF9243_0828	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPREF9243_0829	COG1459	type II secretion system
HMPREF9243_0830	COG4537	Required for transformation and DNA binding
HMPREF9243_0834	COG0006	proline dipeptidase activity
HMPREF9243_0835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMPREF9243_0837	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF9243_0838	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF9243_0839	COG1570	exodeoxyribonuclease VII activity
HMPREF9243_0842	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMPREF9243_0843	COG0497	DNA recombination
HMPREF9243_0844	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF9243_0845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF9243_0847	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_0852	COG1053	succinate dehydrogenase
HMPREF9243_0852	COG3976	FMN-binding domain protein
HMPREF9243_0854	COG2801	Transposase and inactivated derivatives
HMPREF9243_0856	COG1316	TRANSCRIPTIONal
HMPREF9243_0857	COG3944	biosynthesis protein
HMPREF9243_0858	COG0489	protein tyrosine kinase activity
HMPREF9243_0859	COG4464	protein tyrosine phosphatase activity
HMPREF9243_0861	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF9243_0862	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF9243_0863	COG0438	transferase activity, transferring glycosyl groups
HMPREF9243_0871	COG1216	Glycosyl transferase, family 2
HMPREF9243_0871	COG1442	glycosyl transferase family 8
HMPREF9243_0873	COG2244	polysaccharide biosynthetic process
HMPREF9243_0890	COG2326	polyphosphate kinase activity
HMPREF9243_0891	COG3620	sequence-specific DNA binding
HMPREF9243_0893	COG0308	aminopeptidase N
HMPREF9243_0898	COG0561	phosphatase activity
HMPREF9243_0900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9243_0903	COG1295	ribonuclease BN
HMPREF9243_0904	COG0772	Belongs to the SEDS family
HMPREF9243_0905	COG1393	Belongs to the ArsC family
HMPREF9243_0908	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF9243_0909	COG3590	peptidase
HMPREF9243_0910	COG4166	transmembrane transport
HMPREF9243_0911	COG4166	transmembrane transport
HMPREF9243_0912	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF9243_0913	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HMPREF9243_0914	COG0018	arginyl-trna synthetase
HMPREF9243_0921	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9243_0924	COG2084	Dehydrogenase
HMPREF9243_0925	COG1396	sequence-specific DNA binding
HMPREF9243_0932	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF9243_0933	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMPREF9243_0934	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF9243_0935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9243_0936	COG0047	phosphoribosylformylglycinamidine synthase activity
HMPREF9243_0937	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9243_0938	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMPREF9243_0939	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMPREF9243_0940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMPREF9243_0943	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9243_0946	COG2321	neutral zinc metallopeptidase
HMPREF9243_0947	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMPREF9243_0950	COG2183	response to ionizing radiation
HMPREF9243_0953	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF9243_0955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF9243_0956	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9243_0960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF9243_0961	COG1104	cysteine desulfurase activity
HMPREF9243_0963	COG0482	sulfurtransferase activity
HMPREF9243_0964	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF9243_0967	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF9243_0970	COG3906	Belongs to the UPF0473 family
HMPREF9243_0971	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF9243_0972	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF9243_0977	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF9243_0978	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9243_0979	COG2070	2-Nitropropane dioxygenase
HMPREF9243_0980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF9243_0982	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMPREF9243_0984	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HMPREF9243_0985	COG0439	Biotin carboxylase
HMPREF9243_0986	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMPREF9243_0987	COG0825	malonyl-CoA metabolic process
HMPREF9243_0989	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF9243_0993	COG3976	FMN-binding domain protein
HMPREF9243_0993	COG1053	succinate dehydrogenase
HMPREF9243_0994	COG3949	Membrane
HMPREF9243_0996	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9243_0998	COG2801	Transposase and inactivated derivatives
HMPREF9243_1001	COG0116	Belongs to the methyltransferase superfamily
HMPREF9243_1003	COG3599	regulation of cell shape
HMPREF9243_1005	COG2264	protein methyltransferase activity
HMPREF9243_1006	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9243_1007	COG1490	D-aminoacyl-tRNA deacylase activity
HMPREF9243_1011	COG3711	transcriptional antiterminator
HMPREF9243_1013	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_1014	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_1015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_1015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_1015	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HMPREF9243_1016	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9243_1018	COG0124	histidyl-tRNA synthetase
HMPREF9243_1019	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMPREF9243_1023	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF9243_1024	COG0735	belongs to the Fur family
HMPREF9243_1026	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF9243_1032	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HMPREF9243_1033	COG1610	YqeY-like protein
HMPREF9243_1034	COG1702	phosphate starvation-inducible protein PhoH
HMPREF9243_1035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMPREF9243_1037	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMPREF9243_1038	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF9243_1040	COG0752	glycyl-tRNA synthetase alpha subunit
HMPREF9243_1041	COG0751	glycine-tRNA ligase activity
HMPREF9243_1043	COG1234	tRNA 3'-trailer cleavage
HMPREF9243_1048	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF9243_1049	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF9243_1052	COG2131	deaminase
HMPREF9243_1053	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF9243_1054	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HMPREF9243_1055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF9243_1056	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF9243_1057	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF9243_1061	COG1597	lipid kinase activity
HMPREF9243_1062	COG0392	lysyltransferase activity
HMPREF9243_1062	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMPREF9243_1064	COG2190	(PTS) system
HMPREF9243_1064	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9243_1064	COG1263	PTS System
HMPREF9243_1066	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPREF9243_1068	COG2832	Protein of unknown function (DUF454)
HMPREF9243_1070	COG0561	phosphatase activity
HMPREF9243_1074	COG2032	superoxide dismutase activity
HMPREF9243_1087	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HMPREF9243_1089	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF9243_1092	COG2610	gluconate transmembrane transporter activity
HMPREF9243_1094	COG1737	Transcriptional regulator
HMPREF9243_1095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9243_1096	COG4120	Belongs to the binding-protein-dependent transport system permease family
HMPREF9243_1099	COG0464	growth
HMPREF9243_1100	COG1227	inorganic diphosphatase activity
HMPREF9243_1101	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9243_1102	COG0187	DNA topoisomerase II activity
HMPREF9243_1103	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HMPREF9243_1105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF9243_1106	COG0758	DNA mediated transformation
HMPREF9243_1107	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF9243_1108	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF9243_1110	COG3409	Peptidoglycan-binding domain 1 protein
HMPREF9243_1110	COG0793	Belongs to the peptidase S41A family
HMPREF9243_1111	COG4479	Belongs to the UPF0346 family
HMPREF9243_1113	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMPREF9243_1115	COG0488	(ABC) transporter
HMPREF9243_1116	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HMPREF9243_1119	COG2337	Toxic component of a toxin-antitoxin (TA) module
HMPREF9243_1121	COG0481	GTPase activity
HMPREF9243_1123	COG2801	Transposase and inactivated derivatives
HMPREF9243_1125	COG0484	heat shock protein binding
HMPREF9243_1126	COG0443	Heat shock 70 kDa protein
HMPREF9243_1128	COG1420	regulation of RNA biosynthetic process
HMPREF9243_1129	COG0196	riboflavin kinase activity
HMPREF9243_1131	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF9243_1134	COG4120	Belongs to the binding-protein-dependent transport system permease family
HMPREF9243_1136	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMPREF9243_1139	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HMPREF9243_1140	COG0195	Participates in both transcription termination and antitermination
HMPREF9243_1145	COG2176	DNA-directed DNA polymerase activity
HMPREF9243_1146	COG0750	zinc metalloprotease
HMPREF9243_1149	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF9243_1151	COG0528	UMP kinase activity
HMPREF9243_1152	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF9243_1153	COG0052	Belongs to the universal ribosomal protein uS2 family
HMPREF9243_1156	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF9243_1162	COG2610	gluconate transmembrane transporter activity
HMPREF9243_1163	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9243_1169	COG1024	Enoyl-CoA hydratase
HMPREF9243_1170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HMPREF9243_1171	COG1687	branched-chain amino acid
HMPREF9243_1172	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HMPREF9243_1177	COG0204	Acyl-transferase
HMPREF9243_1178	COG3763	UPF0154 protein
HMPREF9243_1179	COG0564	pseudouridine synthase activity
HMPREF9243_1180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF9243_1183	COG1074	ATP-dependent DNA helicase activity
HMPREF9243_1185	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HMPREF9243_1192	COG0297	glycogen (starch) synthase activity
HMPREF9243_1193	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF9243_1197	COG0346	lactoylglutathione lyase activity
HMPREF9243_1199	COG1307	EDD domain protein, DegV family
HMPREF9243_1203	COG1132	(ABC) transporter
HMPREF9243_1206	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF9243_1208	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMPREF9243_1214	COG0540	Belongs to the ATCase OTCase family
HMPREF9243_1216	COG0505	Belongs to the CarA family
HMPREF9243_1218	COG1126	abc transporter atp-binding protein
HMPREF9243_1219	COG0765	amino acid transport
HMPREF9243_1224	COG0527	aspartate kinase activity
HMPREF9243_1225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9243_1228	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HMPREF9243_1230	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF9243_1231	COG3331	DNA recombination
HMPREF9243_1237	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMPREF9243_1238	COG0561	phosphatase activity
HMPREF9243_1239	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF9243_1241	COG0488	(ABC) transporter
HMPREF9243_1242	COG1126	abc transporter atp-binding protein
HMPREF9243_1243	COG0765	amino acid transport
HMPREF9243_1244	COG0765	amino acid transport
HMPREF9243_1245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9243_1248	COG1132	(ABC) transporter
HMPREF9243_1249	COG0628	permease
HMPREF9243_1250	COG1072	(Pantothenic acid kinase))
HMPREF9243_1252	COG4841	protein insertion into membrane
HMPREF9243_1257	COG1272	protein, Hemolysin III
HMPREF9243_1259	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF9243_1261	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9243_1265	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF9243_1266	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF9243_1268	COG3442	glutamine amidotransferase
HMPREF9243_1269	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9243_1270	COG0628	permease
HMPREF9243_1271	COG2706	6-phosphogluconolactonase activity
HMPREF9243_1272	COG1968	undecaprenyl-diphosphatase activity
HMPREF9243_1273	COG0686	Belongs to the AlaDH PNT family
HMPREF9243_1275	COG0019	diaminopimelate decarboxylase activity
HMPREF9243_1276	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF9243_1277	COG2814	Major facilitator Superfamily
HMPREF9243_1278	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF9243_1283	COG1917	Cupin 2, conserved barrel domain protein
HMPREF9243_1283	COG2207	Transcriptional regulator
HMPREF9243_1284	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF9243_1285	COG0557	exoribonuclease II activity
HMPREF9243_1288	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9243_1291	COG0647	UMP catabolic process
HMPREF9243_1294	COG0148	phosphopyruvate hydratase activity
HMPREF9243_1295	COG0149	triose-phosphate isomerase activity
HMPREF9243_1296	COG0126	phosphoglycerate kinase activity
HMPREF9243_1298	COG2390	Transcriptional regulator
HMPREF9243_1299	COG0740	serine-type endopeptidase activity
HMPREF9243_1304	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9243_1309	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_1309	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9243_1309	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_1310	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF9243_1311	COG1349	DNA-binding transcription factor activity
HMPREF9243_1338	COG0166	Belongs to the GPI family
HMPREF9243_1339	COG1098	S1 RNA binding domain
HMPREF9243_1340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF9243_1341	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HMPREF9243_1342	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9243_1343	COG3935	DnaD domain protein
HMPREF9243_1350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMPREF9243_1353	COG1160	GTP binding
HMPREF9243_1354	COG0539	negative regulation of cytoplasmic translation
HMPREF9243_1357	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF9243_1361	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMPREF9243_1363	COG1187	pseudouridine synthase activity
HMPREF9243_1364	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF9243_1371	COG2996	Protein conserved in bacteria
HMPREF9243_1373	COG0205	6-phosphofructokinase activity
HMPREF9243_1374	COG0587	DNA-directed DNA polymerase activity
HMPREF9243_1376	COG2255	four-way junction helicase activity
HMPREF9243_1379	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMPREF9243_1380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMPREF9243_1381	COG0588	phosphoglycerate mutase activity
HMPREF9243_1387	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMPREF9243_1388	COG1058	Belongs to the CinA family
HMPREF9243_1388	COG1546	Belongs to the CinA family
HMPREF9243_1389	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF9243_1391	COG1254	Belongs to the acylphosphatase family
HMPREF9243_1392	COG0706	membrane insertase activity
HMPREF9243_1393	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1394	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF9243_1397	COG1104	cysteine desulfurase activity
HMPREF9243_1398	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HMPREF9243_1399	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMPREF9243_1400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF9243_1404	COG2801	Transposase and inactivated derivatives
HMPREF9243_1406	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMPREF9243_1408	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF9243_1410	COG3599	regulation of cell shape
HMPREF9243_1411	COG2302	S4 RNA-binding domain
HMPREF9243_1412	COG0762	integral membrane protein
HMPREF9243_1413	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF9243_1416	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HMPREF9243_1417	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF9243_1419	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9243_1428	COG1323	Belongs to the UPF0348 family
HMPREF9243_1429	COG2226	methyltransferase
HMPREF9243_1430	COG0799	negative regulation of ribosome biogenesis
HMPREF9243_1431	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPREF9243_1432	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF9243_1433	COG1534	Rna-binding protein
HMPREF9243_1434	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF9243_1435	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HMPREF9243_1436	COG0083	homoserine kinase activity
HMPREF9243_1437	COG0460	homoserine dehydrogenase
HMPREF9243_1438	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF9243_1440	COG0438	transferase activity, transferring glycosyl groups
HMPREF9243_1443	COG0542	response to heat
HMPREF9243_1446	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HMPREF9243_1448	COG0765	amino acid transport
HMPREF9243_1449	COG1394	ATPase activity, coupled to movement of substances
HMPREF9243_1450	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HMPREF9243_1451	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HMPREF9243_1453	COG1527	subunit (C
HMPREF9243_1455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF9243_1456	COG1269	ATP hydrolysis coupled proton transport
HMPREF9243_1458	COG2153	protein acetylation
HMPREF9243_1462	COG2239	Acts as a magnesium transporter
HMPREF9243_1463	COG0564	pseudouridine synthase activity
HMPREF9243_1465	COG4116	CYTH
HMPREF9243_1470	COG1393	Belongs to the ArsC family
HMPREF9243_1471	COG4862	establishment of competence for transformation
HMPREF9243_1475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9243_1476	COG0783	Belongs to the Dps family
HMPREF9243_1477	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF9243_1478	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF9243_1481	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HMPREF9243_1483	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF9243_1485	COG1484	DNA-dependent DNA replication
HMPREF9243_1488	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF9243_1492	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9243_1492	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9243_1494	COG1388	LysM domain
HMPREF9243_1494	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9243_1495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HMPREF9243_1499	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF9243_1501	COG0525	valine-tRNA ligase activity
HMPREF9243_1502	COG2094	Belongs to the DNA glycosylase MPG family
HMPREF9243_1503	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPREF9243_1504	COG1940	carbohydrate kinase activity
HMPREF9243_1505	COG0705	Rhomboid family
HMPREF9243_1505	COG0457	Tetratricopeptide repeat
HMPREF9243_1506	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9243_1509	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HMPREF9243_1512	COG0513	Belongs to the DEAD box helicase family
HMPREF9243_1513	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMPREF9243_1514	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF9243_1515	COG4109	DRTGG domain
HMPREF9243_1519	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9243_1520	COG2801	Transposase and inactivated derivatives
HMPREF9243_1522	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9243_1523	COG0542	response to heat
HMPREF9243_1525	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9243_1526	COG0022	dehydrogenase e1 component
HMPREF9243_1527	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HMPREF9243_1528	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9243_1529	COG0583	DNA-binding transcription factor activity
HMPREF9243_1532	COG0335	large ribosomal subunit rRNA binding
HMPREF9243_1534	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMPREF9243_1535	COG1837	Belongs to the UPF0109 family
HMPREF9243_1536	COG0228	four-way junction DNA binding
HMPREF9243_1541	COG1132	(ABC) transporter
HMPREF9243_1544	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMPREF9243_1546	COG0552	protein localization to endoplasmic reticulum
HMPREF9243_1547	COG0561	phosphatase activity
HMPREF9243_1548	COG1196	nuclear chromosome segregation
HMPREF9243_1550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9243_1551	COG0416	fatty acid biosynthetic process
HMPREF9243_1552	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF9243_1554	COG1461	Dihydroxyacetone kinase
HMPREF9243_1555	COG1302	Protein conserved in bacteria
HMPREF9243_1557	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9243_1558	COG1162	GTPase activity
HMPREF9243_1559	COG2815	serine threonine protein kinase
HMPREF9243_1559	COG0515	serine threonine protein kinase
HMPREF9243_1561	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF9243_1561	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF9243_1562	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF9243_1564	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF9243_1565	COG1758	RNA polymerase activity
HMPREF9243_1569	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF9243_1572	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMPREF9243_1573	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF9243_1574	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMPREF9243_1575	COG0671	phosphoesterase, PA-phosphatase related
HMPREF9243_1576	COG0556	nucleotide-excision repair
HMPREF9243_1577	COG0268	Binds directly to 16S ribosomal RNA
HMPREF9243_1580	COG2333	competence protein COMEC
HMPREF9243_1580	COG0658	competence protein
HMPREF9243_1581	COG1555	photosystem II stabilization
HMPREF9243_1581	COG1596	polysaccharide export
HMPREF9243_1582	COG0742	ribosomal rna small subunit methyltransferase
HMPREF9243_1585	COG4471	UPF0298 protein
HMPREF9243_1586	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HMPREF9243_1587	COG0772	Belongs to the SEDS family
HMPREF9243_1590	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9243_1591	COG4476	Belongs to the UPF0223 family
HMPREF9243_1592	COG1187	pseudouridine synthase activity
HMPREF9243_1593	COG0765	amino acid transport
HMPREF9243_1594	COG0765	amino acid transport
HMPREF9243_1595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9243_1599	COG2801	Transposase and inactivated derivatives
HMPREF9243_1604	COG0242	peptide deformylase activity
HMPREF9243_1606	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMPREF9243_1607	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMPREF9243_1608	COG2855	membrane
HMPREF9243_1610	COG3118	belongs to the thioredoxin family
HMPREF9243_1615	COG2382	esterase
HMPREF9243_1618	COG3425	synthase
HMPREF9243_1619	COG4608	Belongs to the ABC transporter superfamily
HMPREF9243_1620	COG0444	Belongs to the ABC transporter superfamily
HMPREF9243_1621	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9243_1622	COG0601	transmembrane transport
HMPREF9243_1626	COG4166	transmembrane transport
HMPREF9243_1627	COG4166	transmembrane transport
HMPREF9243_1628	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9243_1631	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMPREF9243_1632	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF9243_1634	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9243_1640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMPREF9243_1641	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMPREF9243_1644	COG0489	protein tyrosine kinase activity
HMPREF9243_1647	COG1051	belongs to the nudix hydrolase family
HMPREF9243_1648	COG1307	EDD domain protein, DegV family
HMPREF9243_1652	COG1316	TRANSCRIPTIONal
HMPREF9243_1653	COG0024	Methionine aminopeptidase
HMPREF9243_1655	COG0716	FMN binding
HMPREF9243_1657	COG4166	transmembrane transport
HMPREF9243_1659	COG0463	Glycosyl transferase, family 2
HMPREF9243_1659	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMPREF9243_1661	COG1216	Glycosyl transferase, family 2
HMPREF9243_1662	COG1216	Glycosyl transferase, family 2
HMPREF9243_1663	COG1216	Glycosyl transferase, family 2
HMPREF9243_1665	COG2089	acid synthase
HMPREF9243_1675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF9243_1676	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9243_1677	COG1121	(ABC) transporter
HMPREF9243_1678	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9243_1678	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF9243_1679	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMPREF9243_1680	COG4466	Protein conserved in bacteria
HMPREF9243_1683	COG4555	ABC transporter
HMPREF9243_1684	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF9243_1686	COG0084	hydrolase, TatD family'
HMPREF9243_1687	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9243_1687	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9243_1690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9243_1695	COG2738	Putative neutral zinc metallopeptidase
HMPREF9243_1699	COG0436	Aminotransferase
HMPREF9243_1700	COG1522	sequence-specific DNA binding
HMPREF9243_1702	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMPREF9243_1703	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF9243_1704	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPREF9243_1708	COG5002	protein histidine kinase activity
HMPREF9243_1709	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1715	COG1268	BioY protein
HMPREF9243_1718	COG0561	phosphatase activity
HMPREF9243_1722	COG1957	nucleoside hydrolase
HMPREF9243_1726	COG0181	hydroxymethylbilane synthase activity
HMPREF9243_1727	COG1648	precorrin-2 dehydrogenase activity
HMPREF9243_1727	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF9243_1729	COG1492	cobalamin metabolic process
HMPREF9243_1737	COG2875	Belongs to the precorrin methyltransferase family
HMPREF9243_1739	COG2241	protein methyltransferase activity
HMPREF9243_1740	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HMPREF9243_1742	COG1797	cobyrinic acid a,c-diamide synthase activity
HMPREF9243_1744	COG4166	transmembrane transport
HMPREF9243_1746	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HMPREF9243_1747	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF9243_1749	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HMPREF9243_1750	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HMPREF9243_1753	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPREF9243_1754	COG0549	Belongs to the carbamate kinase family
HMPREF9243_1757	COG0542	response to heat
HMPREF9243_1758	COG1115	amino acid carrier protein
HMPREF9243_1759	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMPREF9243_1761	COG2207	Transcriptional regulator
HMPREF9243_1763	COG1691	(AIR) carboxylase
HMPREF9243_1764	COG1606	tRNA processing
HMPREF9243_1769	COG0435	Glutathione S-transferase
HMPREF9243_1771	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1772	COG2205	protein histidine kinase activity
HMPREF9243_1774	COG1131	(ABC) transporter
HMPREF9243_1775	COG0095	Lipoate-protein ligase
HMPREF9243_1777	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF9243_1777	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9243_1778	COG3250	beta-galactosidase activity
HMPREF9243_1781	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF9243_1784	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF9243_1785	COG0581	inorganic phosphate transmembrane transporter activity
HMPREF9243_1786	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF9243_1787	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF9243_1788	COG5002	protein histidine kinase activity
HMPREF9243_1789	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1791	COG0653	protein targeting
HMPREF9243_1793	COG1040	competence protein
HMPREF9243_1794	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMPREF9243_1795	COG1739	Uncharacterized protein family UPF0029
HMPREF9243_1796	COG2801	Transposase and inactivated derivatives
HMPREF9243_1798	COG0800	Aldolase
HMPREF9243_1799	COG1428	Deoxynucleoside kinase
HMPREF9243_1801	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF9243_1802	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF9243_1804	COG1609	Transcriptional regulator
HMPREF9243_1807	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9243_1808	COG3711	transcriptional antiterminator
HMPREF9243_1809	COG2213	PTS system mannitol-specific
HMPREF9243_1812	COG0765	amino acid transport
HMPREF9243_1813	COG0165	Argininosuccinate lyase
HMPREF9243_1814	COG0765	amino acid transport
HMPREF9243_1816	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9243_1817	COG1288	antiporter activity
HMPREF9243_1818	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HMPREF9243_1820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9243_1822	COG0459	protein refolding
HMPREF9243_1825	COG0488	(ABC) transporter
HMPREF9243_1827	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMPREF9243_1828	COG0456	acetyltransferase
HMPREF9243_1830	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF9243_1831	COG4224	UPF0291 protein
HMPREF9243_1834	COG0708	Exodeoxyribonuclease III
HMPREF9243_1837	COG2801	Transposase and inactivated derivatives
HMPREF9243_1838	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF9243_1840	COG0435	Glutathione S-transferase
HMPREF9243_1850	COG1051	belongs to the nudix hydrolase family
HMPREF9243_1857	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF9243_1858	COG1811	Na channel or pump
HMPREF9243_1859	COG1114	Component of the transport system for branched-chain amino acids
HMPREF9243_1861	COG1301	dicarboxylic acid transport
HMPREF9243_1865	COG0860	N-Acetylmuramoyl-L-alanine amidase
HMPREF9243_1873	COG1304	FMN binding
HMPREF9243_1877	COG1136	(ABC) transporter
HMPREF9243_1878	COG2205	protein histidine kinase activity
HMPREF9243_1879	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1883	COG0789	Transcriptional regulator
HMPREF9243_1889	COG0133	tryptophan synthase activity
HMPREF9243_1890	COG0159	tryptophan synthase activity
HMPREF9243_1896	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF9243_1897	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9243_1905	COG0656	L-ascorbic acid biosynthetic process
HMPREF9243_1911	COG1136	(ABC) transporter
HMPREF9243_1913	COG0745	RESPONSE REGULATOR receiver
HMPREF9243_1914	COG1309	transcriptional regulator
HMPREF9243_1917	COG0577	efflux transmembrane transporter activity
HMPREF9243_1917	COG1136	(ABC) transporter
HMPREF9243_1924	COG1131	(ABC) transporter
HMPREF9243_1926	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF9243_1939	COG1122	ATPase activity
HMPREF9243_1941	COG0789	Transcriptional regulator
HMPREF9243_1944	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF9243_1946	COG0656	L-ascorbic acid biosynthetic process
HMPREF9243_1948	COG1609	Transcriptional regulator
HMPREF9243_1949	COG0737	Belongs to the 5'-nucleotidase family
HMPREF9243_1950	COG3639	organic phosphonate transmembrane transporter activity
HMPREF9243_1951	COG3639	organic phosphonate transmembrane transporter activity
HMPREF9243_1952	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HMPREF9243_1955	COG2801	Transposase and inactivated derivatives
HMPREF9243_1957	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9243_1958	COG0154	amidase activity
HMPREF9243_1959	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9243_1961	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF9243_1962	COG0210	DNA helicase
HMPREF9243_1964	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9243_1966	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF9243_1967	COG0517	IMP dehydrogenase activity
HMPREF9243_1972	COG0411	ABC transporter
HMPREF9243_1977	COG0683	leucine binding
HMPREF9243_1979	COG0577	efflux transmembrane transporter activity
HMPREF9243_1979	COG1136	(ABC) transporter
HMPREF9243_1980	COG0561	phosphatase activity
HMPREF9243_1981	COG4956	integral membrane protein (PIN domain superfamily)
HMPREF9243_1982	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF9243_1983	COG0756	dUTP diphosphatase activity
HMPREF9243_1988	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9243_1988	COG1388	LysM domain
HMPREF9243_1989	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF9243_1991	COG0012	GTP binding
HMPREF9243_1992	COG4481	Protein conserved in bacteria
HMPREF9243_1993	COG1475	DNA binding
HMPREF9243_1994	COG1192	Involved in chromosome partitioning
HMPREF9243_1996	COG1131	(ABC) transporter
HMPREF9243_1997	COG2244	polysaccharide biosynthetic process
HMPREF9243_1998	COG2348	transferase activity, transferring amino-acyl groups
HMPREF9243_2002	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF9243_2003	COG4166	transmembrane transport
HMPREF9243_2004	COG4932	domain protein
HMPREF9243_2004	COG1388	LysM domain
HMPREF9243_2005	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF9243_2006	COG3275	phosphorelay sensor kinase activity
HMPREF9243_2007	COG3279	Response regulator of the LytR AlgR family
HMPREF9243_2009	COG1346	cytolysis
HMPREF9243_2010	COG2814	Major facilitator Superfamily
HMPREF9243_2017	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9243_2018	COG4172	Belongs to the ABC transporter superfamily
HMPREF9243_2020	COG2801	Transposase and inactivated derivatives
HMPREF9243_2021	COG0445	tRNA wobble uridine modification
HMPREF9243_2023	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMPREF9243_2024	COG1122	ATPase activity
HMPREF9243_2027	COG0310	cobalt ion transport
HMPREF9243_2029	COG4536	flavin adenine dinucleotide binding
HMPREF9243_2030	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMPREF9243_2031	COG2217	Heavy metal translocating P-type atpase
HMPREF9243_2032	COG0628	permease
HMPREF9243_2033	COG0393	Putative heavy-metal-binding
HMPREF9243_2037	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF9243_2038	COG3715	PTS system
HMPREF9243_2041	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HMPREF9243_2042	COG1960	acyl-CoA dehydrogenase activity
HMPREF9243_2043	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMPREF9243_2044	COG1847	R3H domain protein
HMPREF9243_2045	COG0706	membrane insertase activity
HMPREF9243_2047	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HMPREF9243_2050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HMPREF9243_2051	COG0022	dehydrogenase e1 component
HMPREF9243_2052	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9243_2058	COG0257	Belongs to the bacterial ribosomal protein bL36 family