locus-tag	class	description
AWM73_00015	COG1335	isochorismatase
AWM73_00045	COG1473	amidohydrolase
AWM73_00095	COG0626	cystathionine gamma-synthase activity
AWM73_00115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM73_00120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM73_00150	COG0157	Belongs to the NadC ModD family
AWM73_00160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AWM73_00165	COG0352	thiamine-phosphate diphosphorylase activity
AWM73_00165	COG0351	phosphomethylpyrimidine kinase
AWM73_00170	COG1012	belongs to the aldehyde dehydrogenase family
AWM73_00170	COG1454	alcohol dehydrogenase
AWM73_00190	COG0756	dUTP diphosphatase activity
AWM73_00195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM73_00200	COG4956	integral membrane protein (PIN domain superfamily)
AWM73_00205	COG0561	phosphatase activity
AWM73_00210	COG0577	efflux transmembrane transporter activity
AWM73_00210	COG1136	(ABC) transporter
AWM73_00245	COG0411	ABC transporter
AWM73_00255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWM73_00255	COG0574	Belongs to the PEP-utilizing enzyme family
AWM73_00260	COG0517	IMP dehydrogenase activity
AWM73_00265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM73_00270	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM73_00280	COG0210	DNA helicase
AWM73_00285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM73_00300	COG0154	amidase activity
AWM73_00305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM73_00325	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWM73_00330	COG3639	organic phosphonate transmembrane transporter activity
AWM73_00335	COG3639	organic phosphonate transmembrane transporter activity
AWM73_00340	COG0737	Belongs to the 5'-nucleotidase family
AWM73_00345	COG1609	Transcriptional regulator
AWM73_00355	COG0656	L-ascorbic acid biosynthetic process
AWM73_00360	COG1073	alpha beta
AWM73_00365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM73_00390	COG1122	ATPase activity
AWM73_00455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM73_00460	COG1131	(ABC) transporter
AWM73_00475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM73_00490	COG1131	(ABC) transporter
AWM73_00525	COG0745	RESPONSE REGULATOR receiver
AWM73_00530	COG5002	protein histidine kinase activity
AWM73_00535	COG1136	(ABC) transporter
AWM73_00545	COG1395	domain, Protein
AWM73_00580	COG0519	Catalyzes the synthesis of GMP from XMP
AWM73_00585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWM73_00610	COG0616	signal peptide processing
AWM73_00615	COG0159	tryptophan synthase activity
AWM73_00620	COG0133	tryptophan synthase activity
AWM73_00630	COG0134	indole-3-glycerol-phosphate synthase activity
AWM73_00640	COG0745	RESPONSE REGULATOR receiver
AWM73_00650	COG1136	(ABC) transporter
AWM73_00660	COG1304	FMN binding
AWM73_00700	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWM73_00715	COG1301	dicarboxylic acid transport
AWM73_00725	COG1114	Component of the transport system for branched-chain amino acids
AWM73_00730	COG1811	Na channel or pump
AWM73_00735	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AWM73_00750	COG0438	transferase activity, transferring glycosyl groups
AWM73_00750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWM73_00760	COG1051	belongs to the nudix hydrolase family
AWM73_00795	COG0435	Glutathione S-transferase
AWM73_00805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM73_00815	COG0708	Exodeoxyribonuclease III
AWM73_00835	COG1857	crispr-associated protein
AWM73_00850	COG1518	maintenance of DNA repeat elements
AWM73_00860	COG1598	PFAM Uncharacterised protein family UPF0150
AWM73_00870	COG4224	UPF0291 protein
AWM73_00875	COG1214	PFAM Peptidase M22, glycoprotease
AWM73_00885	COG0456	acetyltransferase
AWM73_00890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM73_00900	COG0488	(ABC) transporter
AWM73_00915	COG0459	protein refolding
AWM73_00920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWM73_00925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM73_00935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWM73_00940	COG1288	antiporter activity
AWM73_00945	COG1012	belongs to the aldehyde dehydrogenase family
AWM73_00950	COG0765	amino acid transport
AWM73_00955	COG0165	Argininosuccinate lyase
AWM73_00960	COG0765	amino acid transport
AWM73_00975	COG2213	PTS system mannitol-specific
AWM73_00980	COG3711	transcriptional antiterminator
AWM73_00985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM73_01000	COG1609	Transcriptional regulator
AWM73_01005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM73_01010	COG0058	SHG alpha-glucan phosphorylase activity
AWM73_01020	COG1428	Deoxynucleoside kinase
AWM73_01025	COG0800	Aldolase
AWM73_01030	COG1739	Uncharacterized protein family UPF0029
AWM73_01035	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM73_01040	COG1040	competence protein
AWM73_01050	COG0653	protein targeting
AWM73_01055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM73_01060	COG0745	RESPONSE REGULATOR receiver
AWM73_01065	COG5002	protein histidine kinase activity
AWM73_01070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWM73_01075	COG0573	inorganic phosphate transmembrane transporter activity
AWM73_01080	COG0581	inorganic phosphate transmembrane transporter activity
AWM73_01085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM73_01095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM73_01100	COG0569	domain protein
AWM73_01110	COG3250	beta-galactosidase activity
AWM73_01115	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM73_01115	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM73_01125	COG0095	Lipoate-protein ligase
AWM73_01130	COG1131	(ABC) transporter
AWM73_01140	COG2205	protein histidine kinase activity
AWM73_01155	COG0435	Glutathione S-transferase
AWM73_01170	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AWM73_01175	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AWM73_01180	COG1606	tRNA processing
AWM73_01185	COG1691	(AIR) carboxylase
AWM73_01195	COG2207	Transcriptional regulator
AWM73_01200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWM73_01205	COG1115	amino acid carrier protein
AWM73_01210	COG0542	response to heat
AWM73_01225	COG0549	Belongs to the carbamate kinase family
AWM73_01230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWM73_01245	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AWM73_01250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AWM73_01255	COG0406	alpha-ribazole phosphatase activity
AWM73_01260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWM73_01265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AWM73_01275	COG4166	transmembrane transport
AWM73_01285	COG1797	cobyrinic acid a,c-diamide synthase activity
AWM73_01300	COG2241	protein methyltransferase activity
AWM73_01310	COG2875	Belongs to the precorrin methyltransferase family
AWM73_01345	COG1492	cobalamin metabolic process
AWM73_01360	COG0181	hydroxymethylbilane synthase activity
AWM73_01380	COG1957	nucleoside hydrolase
AWM73_01400	COG0561	phosphatase activity
AWM73_01415	COG1268	BioY protein
AWM73_01430	COG0038	chloride channel
AWM73_01440	COG0745	RESPONSE REGULATOR receiver
AWM73_01445	COG5002	protein histidine kinase activity
AWM73_01465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM73_01470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM73_01475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM73_01485	COG1522	sequence-specific DNA binding
AWM73_01490	COG0436	Aminotransferase
AWM73_01510	COG2738	Putative neutral zinc metallopeptidase
AWM73_01525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM73_01535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM73_01535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM73_01540	COG0084	hydrolase, TatD family'
AWM73_01550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM73_01555	COG4555	ABC transporter
AWM73_01570	COG4466	Protein conserved in bacteria
AWM73_01575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM73_01580	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM73_01580	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM73_01585	COG1121	(ABC) transporter
AWM73_01590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM73_01595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM73_01625	COG1083	cytidylyl-transferase
AWM73_01630	COG2089	acid synthase
AWM73_01640	COG1216	Glycosyl transferase, family 2
AWM73_01645	COG1216	Glycosyl transferase, family 2
AWM73_01650	COG1216	Glycosyl transferase, family 2
AWM73_01660	COG0463	Glycosyl transferase, family 2
AWM73_01660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWM73_01680	COG0716	FMN binding
AWM73_01690	COG0024	Methionine aminopeptidase
AWM73_01695	COG1316	TRANSCRIPTIONal
AWM73_01700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWM73_01705	COG0516	GMP reductase activity
AWM73_01715	COG1307	EDD domain protein, DegV family
AWM73_01720	COG1051	belongs to the nudix hydrolase family
AWM73_01735	COG0489	protein tyrosine kinase activity
AWM73_01745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM73_01750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM73_01780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWM73_01790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWM73_01795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM73_01805	COG0006	proline dipeptidase activity
AWM73_01810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM73_01815	COG4166	transmembrane transport
AWM73_01820	COG4166	transmembrane transport
AWM73_01825	COG4166	transmembrane transport
AWM73_01835	COG0601	transmembrane transport
AWM73_01840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM73_01845	COG0444	Belongs to the ABC transporter superfamily
AWM73_01850	COG4608	Belongs to the ABC transporter superfamily
AWM73_01855	COG3425	synthase
AWM73_01895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWM73_01905	COG2855	membrane
AWM73_01910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWM73_01915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AWM73_01925	COG0242	peptide deformylase activity
AWM73_01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM73_01965	COG0765	amino acid transport
AWM73_01970	COG0765	amino acid transport
AWM73_01975	COG1187	pseudouridine synthase activity
AWM73_01980	COG4476	Belongs to the UPF0223 family
AWM73_01985	COG0483	inositol monophosphate 1-phosphatase activity
AWM73_01995	COG0772	Belongs to the SEDS family
AWM73_02000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWM73_02005	COG4471	UPF0298 protein
AWM73_02015	COG3344	reverse transcriptase
AWM73_02025	COG0742	ribosomal rna small subunit methyltransferase
AWM73_02030	COG1555	photosystem II stabilization
AWM73_02030	COG1596	polysaccharide export
AWM73_02035	COG0658	competence protein
AWM73_02035	COG2333	competence protein COMEC
AWM73_02045	COG0268	Binds directly to 16S ribosomal RNA
AWM73_02055	COG0671	phosphoesterase, PA-phosphatase related
AWM73_02060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWM73_02065	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM73_02070	COG3344	reverse transcriptase
AWM73_02075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM73_02090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWM73_02100	COG0194	GDP metabolic process
AWM73_02105	COG1758	RNA polymerase activity
AWM73_02110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM73_02115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM73_02120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM73_02120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM73_02130	COG2815	serine threonine protein kinase
AWM73_02130	COG0515	serine threonine protein kinase
AWM73_02135	COG1162	GTPase activity
AWM73_02140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM73_02150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM73_02155	COG1302	Protein conserved in bacteria
AWM73_02160	COG1461	Dihydroxyacetone kinase
AWM73_02165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM73_02170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM73_02175	COG0416	fatty acid biosynthetic process
AWM73_02180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM73_02185	COG0571	ribonuclease III activity
AWM73_02190	COG1196	nuclear chromosome segregation
AWM73_02195	COG0561	phosphatase activity
AWM73_02200	COG0552	protein localization to endoplasmic reticulum
AWM73_02210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM73_02225	COG1132	(ABC) transporter
AWM73_02235	COG4864	UPF0365 protein
AWM73_02245	COG0228	four-way junction DNA binding
AWM73_02250	COG1837	Belongs to the UPF0109 family
AWM73_02255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWM73_02265	COG0335	large ribosomal subunit rRNA binding
AWM73_02285	COG0583	DNA-binding transcription factor activity
AWM73_02290	COG4221	oxidoreductase activity
AWM73_02295	COG1012	belongs to the aldehyde dehydrogenase family
AWM73_02300	COG0280	phosphate acetyltransferase
AWM73_02305	COG3426	butyrate kinase activity
AWM73_02310	COG1024	Enoyl-CoA hydratase
AWM73_02320	COG0583	DNA-binding transcription factor activity
AWM73_02325	COG2070	2-Nitropropane dioxygenase
AWM73_02335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM73_02340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWM73_02345	COG0022	dehydrogenase e1 component
AWM73_02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWM73_02360	COG0542	response to heat
AWM73_02365	COG0343	queuine tRNA-ribosyltransferase activity
AWM73_02385	COG4109	DRTGG domain
AWM73_02390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM73_02395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWM73_02400	COG0513	Belongs to the DEAD box helicase family
AWM73_02410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWM73_02425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM73_02440	COG1028	Short-chain dehydrogenase reductase Sdr
AWM73_02445	COG0705	Rhomboid family
AWM73_02445	COG0457	Tetratricopeptide repeat
AWM73_02450	COG1940	carbohydrate kinase activity
AWM73_02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM73_02460	COG2094	Belongs to the DNA glycosylase MPG family
AWM73_02465	COG0525	valine-tRNA ligase activity
AWM73_02470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWM73_02475	COG2003	Belongs to the UPF0758 family
AWM73_02485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM73_02490	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM73_02490	COG1388	LysM domain
AWM73_02500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM73_02500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM73_02505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWM73_02515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWM73_02520	COG3611	Membrane attachment protein
AWM73_02525	COG1484	DNA-dependent DNA replication
AWM73_02530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM73_02540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AWM73_02550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWM73_02560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWM73_02565	COG0783	Belongs to the Dps family
AWM73_02570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM73_02590	COG4862	establishment of competence for transformation
AWM73_02595	COG1393	Belongs to the ArsC family
AWM73_02600	COG0180	Tryptophanyl-tRNA synthetase
AWM73_02625	COG0564	pseudouridine synthase activity
AWM73_02630	COG2239	Acts as a magnesium transporter
AWM73_02635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWM73_02640	COG2153	protein acetylation
AWM73_02650	COG1269	ATP hydrolysis coupled proton transport
AWM73_02655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM73_02665	COG1527	subunit (C
AWM73_02675	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM73_02685	COG1394	ATPase activity, coupled to movement of substances
AWM73_02690	COG0765	amino acid transport
AWM73_02700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM73_02710	COG0542	response to heat
AWM73_02725	COG0438	transferase activity, transferring glycosyl groups
AWM73_02735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM73_02740	COG0460	homoserine dehydrogenase
AWM73_02745	COG0083	homoserine kinase activity
AWM73_02750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWM73_02755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM73_02760	COG1534	Rna-binding protein
AWM73_02765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM73_02770	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWM73_02775	COG0799	negative regulation of ribosome biogenesis
AWM73_02780	COG2226	methyltransferase
AWM73_02785	COG1323	Belongs to the UPF0348 family
AWM73_02840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM73_02845	COG0849	cell division
AWM73_02855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM73_02860	COG0762	integral membrane protein
AWM73_02865	COG2302	S4 RNA-binding domain
AWM73_02870	COG3599	regulation of cell shape
AWM73_02875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM73_02880	COG1278	Cold shock
AWM73_02885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM73_02895	COG0494	nUDIX hydrolase
AWM73_02905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWM73_02910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM73_02915	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM73_02920	COG1104	cysteine desulfurase activity
AWM73_02935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWM73_02940	COG0745	RESPONSE REGULATOR receiver
AWM73_02945	COG0706	membrane insertase activity
AWM73_02950	COG1254	Belongs to the acylphosphatase family
AWM73_02955	COG1280	lysine exporter protein (LysE YggA)
AWM73_02955	COG1674	ftsk spoiiie
AWM73_02960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM73_02965	COG1058	Belongs to the CinA family
AWM73_02965	COG1546	Belongs to the CinA family
AWM73_02970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM73_02980	COG0582	viral genome integration into host DNA
AWM73_03115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM73_03120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWM73_03135	COG2255	four-way junction helicase activity
AWM73_03140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM73_03145	COG0587	DNA-directed DNA polymerase activity
AWM73_03150	COG0205	6-phosphofructokinase activity
AWM73_03160	COG2996	Protein conserved in bacteria
AWM73_03170	COG3344	reverse transcriptase
AWM73_03190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM73_03195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM73_03200	COG1187	pseudouridine synthase activity
AWM73_03205	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWM73_03215	COG4372	Transposase
AWM73_03230	COG0514	ATP-dependent DNA helicase (RecQ)
AWM73_03245	COG0539	negative regulation of cytoplasmic translation
AWM73_03250	COG1160	GTP binding
AWM73_03265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM73_03290	COG3935	DnaD domain protein
AWM73_03300	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM73_03305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM73_03310	COG1098	S1 RNA binding domain
AWM73_03315	COG0166	Belongs to the GPI family
AWM73_03460	COG1349	DNA-binding transcription factor activity
AWM73_03465	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM73_03470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM73_03470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM73_03470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM73_03475	COG1464	Belongs to the NlpA lipoprotein family
AWM73_03495	COG0740	serine-type endopeptidase activity
AWM73_03500	COG2390	Transcriptional regulator
AWM73_03510	COG0126	phosphoglycerate kinase activity
AWM73_03515	COG0149	triose-phosphate isomerase activity
AWM73_03520	COG0148	phosphopyruvate hydratase activity
AWM73_03525	COG4470	Protein conserved in bacteria
AWM73_03530	COG0647	UMP catabolic process
AWM73_03545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWM73_03560	COG0557	exoribonuclease II activity
AWM73_03565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWM73_03570	COG1917	Cupin 2, conserved barrel domain protein
AWM73_03570	COG2207	Transcriptional regulator
AWM73_03595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWM73_03600	COG2814	Major facilitator Superfamily
AWM73_03605	COG0704	Plays a role in the regulation of phosphate uptake
AWM73_03610	COG0019	diaminopimelate decarboxylase activity
AWM73_03620	COG0686	Belongs to the AlaDH PNT family
AWM73_03625	COG1968	undecaprenyl-diphosphatase activity
AWM73_03630	COG2706	6-phosphogluconolactonase activity
AWM73_03635	COG0628	permease
AWM73_03640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM73_03645	COG3442	glutamine amidotransferase
AWM73_03655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWM73_03660	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM73_03665	COG0009	L-threonylcarbamoyladenylate synthase
AWM73_03680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM73_03690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWM73_03700	COG1272	protein, Hemolysin III
AWM73_03720	COG4841	protein insertion into membrane
AWM73_03730	COG1072	(Pantothenic acid kinase))
AWM73_03735	COG0628	permease
AWM73_03740	COG1132	(ABC) transporter
AWM73_03745	COG1132	(ABC) transporter
AWM73_03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM73_03760	COG0765	amino acid transport
AWM73_03765	COG0765	amino acid transport
AWM73_03770	COG1126	abc transporter atp-binding protein
AWM73_03775	COG0488	(ABC) transporter
AWM73_03785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWM73_03790	COG0561	phosphatase activity
AWM73_03795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM73_03800	COG3682	Transcriptional regulator
AWM73_03810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM73_03820	COG3331	DNA recombination
AWM73_03825	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWM73_03835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWM73_03840	COG0358	DNA primase activity
AWM73_03845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM73_03850	COG0527	aspartate kinase activity
AWM73_03860	COG1792	Involved in formation and maintenance of cell shape
AWM73_03870	COG0765	amino acid transport
AWM73_03875	COG1126	abc transporter atp-binding protein
AWM73_03880	COG0505	Belongs to the CarA family
AWM73_03890	COG0540	Belongs to the ATCase OTCase family
AWM73_03900	COG0167	dihydroorotate dehydrogenase activity
AWM73_03905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWM73_03915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWM73_03930	COG1132	(ABC) transporter
AWM73_03950	COG1307	EDD domain protein, DegV family
AWM73_03960	COG0346	lactoylglutathione lyase activity
AWM73_03975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM73_03980	COG0297	glycogen (starch) synthase activity
AWM73_04000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM73_04005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM73_04010	COG1074	ATP-dependent DNA helicase activity
AWM73_04025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM73_04030	COG0564	pseudouridine synthase activity
AWM73_04035	COG3763	UPF0154 protein
AWM73_04040	COG0204	Acyl-transferase
AWM73_04065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWM73_04070	COG1687	branched-chain amino acid
AWM73_04075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWM73_04080	COG1024	Enoyl-CoA hydratase
AWM73_04085	COG0583	DNA-binding transcription factor activity
AWM73_04090	COG1028	Short-chain dehydrogenase reductase Sdr
AWM73_04095	COG2610	gluconate transmembrane transporter activity
AWM73_04110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWM73_04125	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM73_04130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWM73_04135	COG0528	UMP kinase activity
AWM73_04145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM73_04150	COG4589	Belongs to the CDS family
AWM73_04155	COG0750	zinc metalloprotease
AWM73_04160	COG2176	DNA-directed DNA polymerase activity
AWM73_04180	COG0779	Required for maturation of 30S ribosomal subunits
AWM73_04185	COG0195	Participates in both transcription termination and antitermination
AWM73_04190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM73_04205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM73_04215	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM73_04220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM73_04230	COG0514	ATP-dependent DNA helicase (RecQ)
AWM73_04240	COG0196	riboflavin kinase activity
AWM73_04245	COG1420	regulation of RNA biosynthetic process
AWM73_04260	COG0484	heat shock protein binding
AWM73_04265	COG0481	GTPase activity
AWM73_04275	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWM73_04285	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM73_04290	COG0488	(ABC) transporter
AWM73_04300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM73_04310	COG4479	Belongs to the UPF0346 family
AWM73_04315	COG0793	Belongs to the peptidase S41A family
AWM73_04315	COG3409	Peptidoglycan-binding domain 1 protein
AWM73_04330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWM73_04335	COG0758	DNA mediated transformation
AWM73_04340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM73_04350	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWM73_04355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWM73_04360	COG0187	DNA topoisomerase II activity
AWM73_04365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM73_04370	COG1227	inorganic diphosphatase activity
AWM73_04380	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM73_04385	COG1116	anion transmembrane transporter activity
AWM73_04390	COG1737	Transcriptional regulator
AWM73_04400	COG2610	gluconate transmembrane transporter activity
AWM73_04405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWM73_04410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWM73_04460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM73_04480	COG2032	superoxide dismutase activity
AWM73_04500	COG0561	phosphatase activity
AWM73_04510	COG2832	Protein of unknown function (DUF454)
AWM73_04520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM73_04540	COG0392	lysyltransferase activity
AWM73_04540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AWM73_04545	COG1597	lipid kinase activity
AWM73_04565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM73_04570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM73_04575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM73_04580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM73_04585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM73_04590	COG2131	deaminase
AWM73_04605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWM73_04610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM73_04615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM73_04615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM73_04620	COG4221	oxidoreductase activity
AWM73_04635	COG0751	glycine-tRNA ligase activity
AWM73_04640	COG0752	glycyl-tRNA synthetase alpha subunit
AWM73_04645	COG1381	Involved in DNA repair and RecF pathway recombination
AWM73_04650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM73_04660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM73_04665	COG1702	phosphate starvation-inducible protein PhoH
AWM73_04670	COG1610	YqeY-like protein
AWM73_04675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWM73_04700	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM73_04710	COG0735	belongs to the Fur family
AWM73_04715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM73_04730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM73_04735	COG0124	histidyl-tRNA synthetase
AWM73_04745	COG1490	D-aminoacyl-tRNA deacylase activity
AWM73_04750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM73_04755	COG2264	protein methyltransferase activity
AWM73_04765	COG3599	regulation of cell shape
AWM73_04775	COG0116	Belongs to the methyltransferase superfamily
AWM73_04785	COG0483	inositol monophosphate 1-phosphatase activity
AWM73_04795	COG3949	Membrane
AWM73_04800	COG3976	FMN-binding domain protein
AWM73_04800	COG1053	succinate dehydrogenase
AWM73_04815	COG3976	FMN-binding domain protein
AWM73_04815	COG1053	succinate dehydrogenase
AWM73_04820	COG0328	RNA-DNA hybrid ribonuclease activity
AWM73_04830	COG0825	malonyl-CoA metabolic process
AWM73_04835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWM73_04840	COG0439	Biotin carboxylase
AWM73_04845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWM73_04855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM73_04865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWM73_04870	COG2070	2-Nitropropane dioxygenase
AWM73_04875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM73_04880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWM73_04895	COG1114	Component of the transport system for branched-chain amino acids
AWM73_04900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM73_04905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM73_04910	COG3906	Belongs to the UPF0473 family
AWM73_04925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM73_04935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM73_04940	COG0482	sulfurtransferase activity
AWM73_04950	COG1104	cysteine desulfurase activity
AWM73_04955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM73_04970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM73_04975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM73_05010	COG2183	response to ionizing radiation
AWM73_05020	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM73_05025	COG2321	neutral zinc metallopeptidase
AWM73_05040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM73_05045	COG0151	Belongs to the GarS family
AWM73_05050	COG0138	bifunctional purine biosynthesis protein purh
AWM73_05055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM73_05060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWM73_05065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWM73_05070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM73_05075	COG0047	phosphoribosylformylglycinamidine synthase activity
AWM73_05080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM73_05085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWM73_05090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWM73_05095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM73_05120	COG2084	Dehydrogenase
AWM73_05135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM73_05165	COG0018	arginyl-trna synthetase
AWM73_05170	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AWM73_05175	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM73_05180	COG4166	transmembrane transport
AWM73_05185	COG4166	transmembrane transport
AWM73_05190	COG3590	peptidase
AWM73_05195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM73_05210	COG1393	Belongs to the ArsC family
AWM73_05215	COG0772	Belongs to the SEDS family
AWM73_05220	COG1295	ribonuclease BN
AWM73_05235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM73_05245	COG0561	phosphatase activity
AWM73_05260	COG0308	aminopeptidase N
AWM73_05270	COG3620	sequence-specific DNA binding
AWM73_05275	COG2326	polyphosphate kinase activity
AWM73_05310	COG4372	Transposase
AWM73_05355	COG2244	polysaccharide biosynthetic process
AWM73_05360	COG1215	transferase activity, transferring glycosyl groups
AWM73_05365	COG1216	Glycosyl transferase, family 2
AWM73_05365	COG1442	glycosyl transferase family 8
AWM73_05390	COG1086	Polysaccharide biosynthesis protein
AWM73_05405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM73_05415	COG4464	protein tyrosine phosphatase activity
AWM73_05420	COG0489	protein tyrosine kinase activity
AWM73_05425	COG3944	biosynthesis protein
AWM73_05430	COG1316	TRANSCRIPTIONal
AWM73_05435	COG3976	FMN-binding domain protein
AWM73_05435	COG1053	succinate dehydrogenase
AWM73_05460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWM73_05465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM73_05470	COG0497	DNA recombination
AWM73_05475	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM73_05490	COG1570	exodeoxyribonuclease VII activity
AWM73_05495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM73_05500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM73_05510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWM73_05515	COG0006	proline dipeptidase activity
AWM73_05540	COG4537	Required for transformation and DNA binding
AWM73_05545	COG1459	type II secretion system
AWM73_05550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM73_05565	COG1269	ATP hydrolysis coupled proton transport
AWM73_05595	COG1394	ATPase activity, coupled to movement of substances
AWM73_05600	COG4980	gas vesicle protein
AWM73_05610	COG0668	transmembrane transport
AWM73_05615	COG0622	Phosphoesterase
AWM73_05620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM73_05630	COG0786	glutamate:sodium symporter activity
AWM73_05635	COG1803	Methylglyoxal synthase
AWM73_05645	COG3118	belongs to the thioredoxin family
AWM73_05665	COG1263	PTS System
AWM73_05665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_05680	COG1136	(ABC) transporter
AWM73_05680	COG0577	efflux transmembrane transporter activity
AWM73_05700	COG1720	tRNA m6t6A37 methyltransferase activity
AWM73_05705	COG0596	Alpha beta hydrolase
AWM73_05715	COG1363	Peptidase, m42
AWM73_05740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWM73_05740	COG0519	Catalyzes the synthesis of GMP from XMP
AWM73_05745	COG0083	homoserine kinase activity
AWM73_05760	COG1304	FMN binding
AWM73_05765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM73_05770	COG1045	serine acetyltransferase
AWM73_05785	COG1442	glycosyl transferase family 8
AWM73_05785	COG1216	Glycosyl transferase, family 2
AWM73_05795	COG0653	protein targeting
AWM73_05805	COG1073	alpha beta
AWM73_05845	COG1464	Belongs to the NlpA lipoprotein family
AWM73_05855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM73_05860	COG0431	NADPH-dependent FMN reductase
AWM73_05880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AWM73_05885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AWM73_05890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM73_05915	COG0395	ABC-type sugar transport system, permease component
AWM73_05920	COG1175	transmembrane transport
AWM73_05925	COG3842	ATPase activity
AWM73_05930	COG2918	glutathione biosynthetic process
AWM73_05930	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM73_05940	COG0028	Belongs to the TPP enzyme family
AWM73_05950	COG0431	NADPH-dependent FMN reductase
AWM73_05955	COG0588	phosphoglycerate mutase activity
AWM73_05960	COG0588	phosphoglycerate mutase activity
AWM73_05985	COG1263	PTS System
AWM73_05985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_05985	COG2190	(PTS) system
AWM73_06005	COG1053	succinate dehydrogenase
AWM73_06035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWM73_06045	COG1132	(ABC) transporter
AWM73_06065	COG3949	Membrane
AWM73_06070	COG1136	(ABC) transporter
AWM73_06075	COG0577	efflux transmembrane transporter activity
AWM73_06080	COG3579	cysteine-type endopeptidase activity
AWM73_06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM73_06105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM73_06105	COG1116	anion transmembrane transporter activity
AWM73_06125	COG0406	alpha-ribazole phosphatase activity
AWM73_06130	COG1122	ATPase activity
AWM73_06135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM73_06150	COG0802	atpase or kinase
AWM73_06155	COG4475	Protein of unknown function (DUF436)
AWM73_06160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM73_06180	COG0280	phosphate acetyltransferase
AWM73_06185	COG1115	amino acid carrier protein
AWM73_06190	COG0072	phenylalanine-tRNA ligase activity
AWM73_06190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM73_06195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM73_06200	COG1733	regulation of RNA biosynthetic process
AWM73_06210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM73_06220	COG1640	4-alpha-glucanotransferase
AWM73_06225	COG2244	polysaccharide biosynthetic process
AWM73_06240	COG0765	amino acid transport
AWM73_06245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM73_06250	COG1126	abc transporter atp-binding protein
AWM73_06260	COG0495	leucyl-tRNA aminoacylation
AWM73_06285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM73_06295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM73_06305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWM73_06320	COG1131	(ABC) transporter
AWM73_06325	COG0537	adenosine 5'-monophosphoramidase activity
AWM73_06340	COG1442	glycosyl transferase family 8
AWM73_06345	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWM73_06350	COG4717	serine-type aminopeptidase activity
AWM73_06355	COG0420	3'-5' exonuclease activity
AWM73_06360	COG3679	Belongs to the UPF0342 family
AWM73_06365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM73_06370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM73_06375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM73_06380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM73_06385	COG0517	IMP dehydrogenase activity
AWM73_06385	COG0516	GMP reductase activity
AWM73_06430	COG1957	nucleoside hydrolase
AWM73_06445	COG1653	transport
AWM73_06450	COG3842	ATPase activity
AWM73_06455	COG0395	ABC-type sugar transport system, permease component
AWM73_06465	COG1653	transport
AWM73_06470	COG1653	transport
AWM73_06500	COG2059	Chromate
AWM73_06590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM73_06595	COG0735	belongs to the Fur family
AWM73_06600	COG4129	membrane
AWM73_06605	COG1523	belongs to the glycosyl hydrolase 13 family
AWM73_06620	COG1194	a g-specific adenine glycosylase
AWM73_06625	COG2137	regulation of response to DNA damage stimulus
AWM73_06650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM73_06690	COG0668	transmembrane transport
AWM73_06695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM73_06715	COG0402	S-adenosylhomocysteine deaminase activity
AWM73_06720	COG0604	alcohol dehydrogenase
AWM73_06730	COG0564	pseudouridine synthase activity
AWM73_06750	COG0517	IMP dehydrogenase activity
AWM73_06750	COG1125	glycine betaine transport
AWM73_06765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM73_06770	COG1597	lipid kinase activity
AWM73_06775	COG1902	pentaerythritol trinitrate reductase activity
AWM73_06780	COG2814	Major facilitator Superfamily
AWM73_06810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM73_06820	COG0101	tRNA pseudouridine synthase activity
AWM73_06830	COG1122	ATPase activity
AWM73_06835	COG1122	ATPase activity
AWM73_06845	COG0203	ribosomal protein L17
AWM73_06850	COG0202	RNA polymerase activity
AWM73_06855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWM73_06865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWM73_06880	COG0200	Binds to the 23S rRNA
AWM73_06885	COG1841	ribosomal large subunit assembly
AWM73_06890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM73_06895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM73_06905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWM73_06910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM73_06915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWM73_06925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM73_06930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM73_06935	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM73_06940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM73_06955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWM73_06960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWM73_06965	COG0089	rRNA binding
AWM73_06975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM73_06980	COG0051	transcription antitermination factor activity, RNA binding
AWM73_06990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM73_06995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM73_07000	COG0049	tRNA binding
AWM73_07005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM73_07015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM73_07020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM73_07030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM73_07035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM73_07045	COG0037	tRNA processing
AWM73_07050	COG1098	S1 RNA binding domain
AWM73_07060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM73_07065	COG2244	polysaccharide biosynthetic process
AWM73_07070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM73_07075	COG0193	aminoacyl-tRNA hydrolase activity
AWM73_07080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM73_07100	COG0322	excinuclease ABC activity
AWM73_07130	COG0463	Glycosyl transferase, family 2
AWM73_07135	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AWM73_07160	COG1253	flavin adenine dinucleotide binding
AWM73_07170	COG1131	(ABC) transporter
AWM73_07180	COG0789	Transcriptional regulator
AWM73_07195	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWM73_07200	COG0736	holo-[acyl-carrier-protein] synthase activity
AWM73_07210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM73_07215	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM73_07230	COG3764	Sortase (surface protein transpeptidase)
AWM73_07235	COG0254	rRNA binding
AWM73_07240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWM73_07245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM73_07250	COG3343	RNA polymerase activity
AWM73_07260	COG0095	Lipoate-protein ligase
AWM73_07265	COG1078	dGTPase activity
AWM73_07270	COG0436	Aminotransferase
AWM73_07280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWM73_07285	COG1970	mechanosensitive ion channel activity
AWM73_07295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWM73_07305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM73_07310	COG4467	Involved in initiation control of chromosome replication
AWM73_07320	COG0470	DNA polymerase III
AWM73_07330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM73_07340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM73_07350	COG0590	tRNA wobble adenosine to inosine editing
AWM73_07355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWM73_07365	COG0542	response to heat
AWM73_07370	COG4463	regulation of RNA biosynthetic process
AWM73_07375	COG1230	cation diffusion facilitator family transporter
AWM73_07385	COG1131	(ABC) transporter
AWM73_07435	COG2096	Adenosyltransferase
AWM73_07445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM73_07455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM73_07460	COG0584	glycerophosphoryl diester phosphodiesterase
AWM73_07465	COG2848	UPF0210 protein
AWM73_07490	COG3448	diguanylate cyclase activity
AWM73_07490	COG4175	Glycine betaine
AWM73_07495	COG2813	Specifically methylates the guanine in position
AWM73_07505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM73_07510	COG1609	Transcriptional regulator
AWM73_07520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWM73_07525	COG0081	regulation of translation
AWM73_07530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AWM73_07540	COG0250	Participates in transcription elongation, termination and antitermination
AWM73_07545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWM73_07555	COG3688	RNA-binding protein containing a PIN domain
AWM73_07560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM73_07565	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM73_07570	COG0215	cysteine-tRNA ligase activity
AWM73_07580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM73_07585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM73_07600	COG1187	pseudouridine synthase activity
AWM73_07605	COG4684	Psort location CytoplasmicMembrane, score
AWM73_07615	COG0561	phosphatase activity
AWM73_07620	COG0366	Alpha amylase catalytic
AWM73_07635	COG3189	MarR family transcriptional regulator
AWM73_07640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM73_07645	COG2190	(PTS) system
AWM73_07645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_07645	COG1263	PTS System
AWM73_07650	COG3022	response to hydroperoxide
AWM73_07665	COG1028	Short-chain dehydrogenase reductase Sdr
AWM73_07675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM73_07685	COG5002	protein histidine kinase activity
AWM73_07685	COG3850	Histidine kinase
AWM73_07690	COG0745	RESPONSE REGULATOR receiver
AWM73_07705	COG1481	regulation of sporulation
AWM73_07710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWM73_07720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM73_07740	COG0492	ferredoxin-NADP+ reductase activity
AWM73_07750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWM73_07755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM73_07760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWM73_07775	COG0419	ATPase involved in DNA repair
AWM73_07780	COG0420	3'-5' exonuclease activity
AWM73_07785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWM73_07830	COG1942	4-Oxalocrotonate Tautomerase
AWM73_07845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM73_07850	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM73_07860	COG2070	2-Nitropropane dioxygenase
AWM73_07865	COG0693	protein deglycase activity
AWM73_07875	COG3732	PTS system glucitol sorbitol-specific
AWM73_07880	COG3730	PTS system glucitol sorbitol-specific
AWM73_07885	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM73_07900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM73_07910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM73_07920	COG1063	alcohol dehydrogenase
AWM73_07925	COG3775	system Galactitol-specific IIC component
AWM73_07930	COG3414	Phosphotransferase system galactitol-specific IIB component
AWM73_07945	COG4989	oxidoreductase activity
AWM73_07950	COG2390	Transcriptional regulator
AWM73_07955	COG1028	Short-chain dehydrogenase reductase Sdr
AWM73_07965	COG2022	thiamine diphosphate biosynthetic process
AWM73_07975	COG2390	Transcriptional regulator
AWM73_07980	COG3716	PTS system mannose fructose sorbose family IID component
AWM73_07985	COG3715	PTS system
AWM73_07990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_07995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_07995	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM73_08000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AWM73_08005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM73_08010	COG1349	DNA-binding transcription factor activity
AWM73_08020	COG3716	PTS system mannose fructose sorbose family IID component
AWM73_08025	COG3715	PTS system
AWM73_08030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_08035	COG0673	inositol 2-dehydrogenase activity
AWM73_08040	COG2851	Citrate transporter
AWM73_08045	COG0710	3-dehydroquinate dehydratase activity
AWM73_08050	COG0738	Major facilitator superfamily
AWM73_08055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM73_08060	COG0583	DNA-binding transcription factor activity
AWM73_08065	COG0431	NADPH-dependent FMN reductase
AWM73_08065	COG1053	succinate dehydrogenase
AWM73_08065	COG3976	FMN-binding domain protein
AWM73_08070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM73_08080	COG4565	transcriptional regulatory protein
AWM73_08085	COG3290	protein histidine kinase activity
AWM73_08090	COG1737	Transcriptional regulator
AWM73_08095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM73_08095	COG1263	PTS System
AWM73_08100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AWM73_08110	COG1028	Short-chain dehydrogenase reductase Sdr
AWM73_08115	COG3976	FMN-binding domain protein
AWM73_08115	COG1053	succinate dehydrogenase
AWM73_08115	COG0431	NADPH-dependent FMN reductase
AWM73_08120	COG3976	FMN-binding domain protein
AWM73_08120	COG1053	succinate dehydrogenase
AWM73_08225	COG2011	ABC-type metal ion transport system permease component
AWM73_08230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM73_08235	COG1464	Belongs to the NlpA lipoprotein family
AWM73_08250	COG0456	acetyltransferase
AWM73_08270	COG4115	mRNA cleavage
AWM73_08285	COG1024	Enoyl-CoA hydratase
AWM73_08290	COG0583	DNA-binding transcription factor activity
AWM73_08295	COG0483	inositol monophosphate 1-phosphatase activity
AWM73_08300	COG3118	belongs to the thioredoxin family
AWM73_08310	COG0778	Nitroreductase
AWM73_08315	COG0778	Nitroreductase
AWM73_08320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM73_08335	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM73_08340	COG1349	DNA-binding transcription factor activity
AWM73_08360	COG3775	system Galactitol-specific IIC component
AWM73_08365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM73_08370	COG1053	succinate dehydrogenase
AWM73_08375	COG0471	metal ion transport
AWM73_08390	COG0583	DNA-binding transcription factor activity
AWM73_08395	COG0789	Transcriptional regulator
AWM73_08400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWM73_08425	COG2217	Heavy metal translocating P-type atpase
AWM73_08440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM73_08450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM73_08460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AWM73_08465	COG0402	S-adenosylhomocysteine deaminase activity
AWM73_08470	COG1116	anion transmembrane transporter activity
AWM73_08480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWM73_08485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM73_08490	COG2391	methyltransferase activity
AWM73_08495	COG3279	Response regulator of the LytR AlgR family
AWM73_08510	COG5002	protein histidine kinase activity
AWM73_08525	COG0438	transferase activity, transferring glycosyl groups
AWM73_08535	COG1388	LysM domain
AWM73_08535	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM73_08540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AWM73_08550	COG0012	GTP binding
AWM73_08555	COG4481	Protein conserved in bacteria
AWM73_08560	COG1475	DNA binding
AWM73_08565	COG1192	Involved in chromosome partitioning
AWM73_08570	COG2244	polysaccharide biosynthetic process
AWM73_08575	COG2348	transferase activity, transferring amino-acyl groups
AWM73_08595	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM73_08600	COG1388	LysM domain
AWM73_08600	COG4932	domain protein
AWM73_08605	COG0357	Ribosomal RNA small subunit methyltransferase G
AWM73_08610	COG3275	phosphorelay sensor kinase activity
AWM73_08615	COG3279	Response regulator of the LytR AlgR family
AWM73_08625	COG1346	cytolysis
AWM73_08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM73_08675	COG0445	tRNA wobble uridine modification
AWM73_08685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM73_08690	COG1122	ATPase activity
AWM73_08705	COG0310	cobalt ion transport
AWM73_08710	COG4536	flavin adenine dinucleotide binding
AWM73_08715	COG2217	Heavy metal translocating P-type atpase
AWM73_08720	COG0628	permease
AWM73_08725	COG0393	Putative heavy-metal-binding
AWM73_08740	COG3716	PTS system mannose fructose sorbose family IID component
AWM73_08745	COG3715	PTS system
AWM73_08760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AWM73_08765	COG1960	acyl-CoA dehydrogenase activity
AWM73_08770	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWM73_08775	COG1847	R3H domain protein
AWM73_08780	COG0706	membrane insertase activity
AWM73_08790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM73_08795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWM73_08800	COG0022	dehydrogenase e1 component
AWM73_08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWM73_08825	COG0592	DNA-directed DNA polymerase activity
AWM73_08830	COG0277	FAD linked oxidase domain protein
AWM73_08835	COG2501	S4 domain
AWM73_08840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM73_08845	COG0187	DNA topoisomerase II activity
AWM73_08850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM73_08855	COG4152	abc transporter atp-binding protein
AWM73_08860	COG1668	transmembrane transport
AWM73_08880	COG1288	antiporter activity
AWM73_08885	COG1473	amidohydrolase
AWM73_08890	COG0360	Binds together with S18 to 16S ribosomal RNA
AWM73_08895	COG0629	single-stranded DNA binding
AWM73_08900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWM73_08920	COG4619	ABC transporter
AWM73_08925	COG0390	transport system, permease component
AWM73_08930	COG0390	transport system, permease component
AWM73_08935	COG0359	binds to the 23S rRNA
AWM73_08940	COG0305	Participates in initiation and elongation during chromosome replication
AWM73_08955	COG1454	alcohol dehydrogenase
AWM73_08965	COG1620	l-lactate permease
AWM73_08975	COG0133	tryptophan synthase activity
AWM73_08985	COG1228	amidohydrolase