locus-tag	class	description
I6G68_00005	COG0058	SHG alpha-glucan phosphorylase activity
I6G68_00010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G68_00030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_00035	COG3711	transcriptional antiterminator
I6G68_00040	COG2213	PTS system mannitol-specific
I6G68_00055	COG0765	amino acid transport
I6G68_00060	COG0165	Argininosuccinate lyase
I6G68_00065	COG0765	amino acid transport
I6G68_00070	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_00075	COG1288	antiporter activity
I6G68_00080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G68_00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G68_00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G68_00100	COG0459	protein refolding
I6G68_00115	COG0488	(ABC) transporter
I6G68_00125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G68_00130	COG0456	acetyltransferase
I6G68_00140	COG1214	PFAM Peptidase M22, glycoprotease
I6G68_00145	COG4224	UPF0291 protein
I6G68_00155	COG1598	PFAM Uncharacterised protein family UPF0150
I6G68_00170	COG1518	maintenance of DNA repeat elements
I6G68_00185	COG1857	crispr-associated protein
I6G68_00205	COG0708	Exodeoxyribonuclease III
I6G68_00225	COG0435	Glutathione S-transferase
I6G68_00260	COG1051	belongs to the nudix hydrolase family
I6G68_00270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G68_00270	COG0438	transferase activity, transferring glycosyl groups
I6G68_00285	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G68_00290	COG1811	Na channel or pump
I6G68_00295	COG1114	Component of the transport system for branched-chain amino acids
I6G68_00305	COG1301	dicarboxylic acid transport
I6G68_00320	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G68_00325	COG1054	Belongs to the UPF0176 family
I6G68_00360	COG1304	FMN binding
I6G68_00370	COG1136	(ABC) transporter
I6G68_00380	COG0745	RESPONSE REGULATOR receiver
I6G68_00390	COG0134	indole-3-glycerol-phosphate synthase activity
I6G68_00400	COG0133	tryptophan synthase activity
I6G68_00405	COG0159	tryptophan synthase activity
I6G68_00410	COG0616	signal peptide processing
I6G68_00435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G68_00440	COG0519	Catalyzes the synthesis of GMP from XMP
I6G68_00475	COG1395	domain, Protein
I6G68_00485	COG1136	(ABC) transporter
I6G68_00490	COG5002	protein histidine kinase activity
I6G68_00495	COG0745	RESPONSE REGULATOR receiver
I6G68_00535	COG1131	(ABC) transporter
I6G68_00550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G68_00565	COG1131	(ABC) transporter
I6G68_00570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G68_00635	COG1122	ATPase activity
I6G68_00660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G68_00665	COG1073	alpha beta
I6G68_00670	COG0656	L-ascorbic acid biosynthetic process
I6G68_00680	COG1609	Transcriptional regulator
I6G68_00685	COG0737	Belongs to the 5'-nucleotidase family
I6G68_00690	COG3639	organic phosphonate transmembrane transporter activity
I6G68_00695	COG3639	organic phosphonate transmembrane transporter activity
I6G68_00700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G68_00720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G68_00725	COG0154	amidase activity
I6G68_00740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G68_00745	COG0210	DNA helicase
I6G68_00755	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_00760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G68_00765	COG0517	IMP dehydrogenase activity
I6G68_00770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G68_00770	COG0574	Belongs to the PEP-utilizing enzyme family
I6G68_00780	COG0411	ABC transporter
I6G68_00815	COG0577	efflux transmembrane transporter activity
I6G68_00815	COG1136	(ABC) transporter
I6G68_00820	COG0561	phosphatase activity
I6G68_00825	COG4956	integral membrane protein (PIN domain superfamily)
I6G68_00830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G68_00835	COG0756	dUTP diphosphatase activity
I6G68_00855	COG1454	alcohol dehydrogenase
I6G68_00855	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_00860	COG0352	thiamine-phosphate diphosphorylase activity
I6G68_00860	COG0351	phosphomethylpyrimidine kinase
I6G68_00865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G68_00875	COG0157	Belongs to the NadC ModD family
I6G68_00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G68_00910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G68_00930	COG0626	cystathionine gamma-synthase activity
I6G68_00980	COG1473	amidohydrolase
I6G68_01010	COG1335	isochorismatase
I6G68_01020	COG1228	amidohydrolase
I6G68_01030	COG0133	tryptophan synthase activity
I6G68_01040	COG1620	l-lactate permease
I6G68_01050	COG1454	alcohol dehydrogenase
I6G68_01070	COG0305	Participates in initiation and elongation during chromosome replication
I6G68_01075	COG0359	binds to the 23S rRNA
I6G68_01080	COG0390	transport system, permease component
I6G68_01085	COG0390	transport system, permease component
I6G68_01090	COG4619	ABC transporter
I6G68_01110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G68_01115	COG0629	single-stranded DNA binding
I6G68_01120	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G68_01125	COG1473	amidohydrolase
I6G68_01130	COG1288	antiporter activity
I6G68_01150	COG1668	transmembrane transport
I6G68_01155	COG4152	abc transporter atp-binding protein
I6G68_01160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G68_01165	COG0187	DNA topoisomerase II activity
I6G68_01170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G68_01175	COG2501	S4 domain
I6G68_01180	COG0277	FAD linked oxidase domain protein
I6G68_01185	COG0592	DNA-directed DNA polymerase activity
I6G68_01200	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G68_01205	COG0022	dehydrogenase e1 component
I6G68_01210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G68_01215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_01220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G68_01230	COG0706	membrane insertase activity
I6G68_01235	COG1847	R3H domain protein
I6G68_01240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G68_01245	COG1960	acyl-CoA dehydrogenase activity
I6G68_01250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G68_01265	COG3715	PTS system
I6G68_01270	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_01285	COG0393	Putative heavy-metal-binding
I6G68_01290	COG0628	permease
I6G68_01295	COG2217	Heavy metal translocating P-type atpase
I6G68_01300	COG4536	flavin adenine dinucleotide binding
I6G68_01305	COG0310	cobalt ion transport
I6G68_01320	COG1122	ATPase activity
I6G68_01325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G68_01335	COG0445	tRNA wobble uridine modification
I6G68_01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G68_01380	COG1346	cytolysis
I6G68_01390	COG3279	Response regulator of the LytR AlgR family
I6G68_01395	COG3275	phosphorelay sensor kinase activity
I6G68_01400	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G68_01405	COG1388	LysM domain
I6G68_01405	COG4932	domain protein
I6G68_01410	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G68_01430	COG2348	transferase activity, transferring amino-acyl groups
I6G68_01435	COG2244	polysaccharide biosynthetic process
I6G68_01445	COG1192	Involved in chromosome partitioning
I6G68_01450	COG1475	DNA binding
I6G68_01455	COG4481	Protein conserved in bacteria
I6G68_01460	COG0012	GTP binding
I6G68_01475	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_01475	COG1388	LysM domain
I6G68_01485	COG0438	transferase activity, transferring glycosyl groups
I6G68_01500	COG5002	protein histidine kinase activity
I6G68_01515	COG3279	Response regulator of the LytR AlgR family
I6G68_01520	COG2391	methyltransferase activity
I6G68_01525	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_01530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G68_01545	COG1116	anion transmembrane transporter activity
I6G68_01550	COG0402	S-adenosylhomocysteine deaminase activity
I6G68_01555	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G68_01560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G68_01570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G68_01585	COG2217	Heavy metal translocating P-type atpase
I6G68_01610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G68_01615	COG0789	Transcriptional regulator
I6G68_01620	COG0583	DNA-binding transcription factor activity
I6G68_01635	COG0471	metal ion transport
I6G68_01640	COG1053	succinate dehydrogenase
I6G68_01645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_01650	COG3775	system Galactitol-specific IIC component
I6G68_01670	COG1349	DNA-binding transcription factor activity
I6G68_01675	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G68_01690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G68_01695	COG0778	Nitroreductase
I6G68_01700	COG0778	Nitroreductase
I6G68_01710	COG3118	belongs to the thioredoxin family
I6G68_01715	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_01720	COG0583	DNA-binding transcription factor activity
I6G68_01725	COG1024	Enoyl-CoA hydratase
I6G68_01740	COG4115	mRNA cleavage
I6G68_01760	COG0456	acetyltransferase
I6G68_01775	COG1464	Belongs to the NlpA lipoprotein family
I6G68_01780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_01785	COG2011	ABC-type metal ion transport system permease component
I6G68_01895	COG1053	succinate dehydrogenase
I6G68_01895	COG3976	FMN-binding domain protein
I6G68_01900	COG3976	FMN-binding domain protein
I6G68_01900	COG1053	succinate dehydrogenase
I6G68_01900	COG0431	NADPH-dependent FMN reductase
I6G68_01905	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_01915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G68_01920	COG1263	PTS System
I6G68_01920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_01925	COG1737	Transcriptional regulator
I6G68_01930	COG3290	protein histidine kinase activity
I6G68_01935	COG4565	transcriptional regulatory protein
I6G68_01945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G68_01950	COG3976	FMN-binding domain protein
I6G68_01950	COG1053	succinate dehydrogenase
I6G68_01950	COG0431	NADPH-dependent FMN reductase
I6G68_01955	COG0583	DNA-binding transcription factor activity
I6G68_01960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G68_01965	COG0738	Major facilitator superfamily
I6G68_01970	COG0710	3-dehydroquinate dehydratase activity
I6G68_01975	COG2851	Citrate transporter
I6G68_01980	COG0673	inositol 2-dehydrogenase activity
I6G68_01985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_01990	COG3715	PTS system
I6G68_01995	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_02005	COG1349	DNA-binding transcription factor activity
I6G68_02010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G68_02020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_02020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_02025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_02030	COG3715	PTS system
I6G68_02035	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_02040	COG2390	Transcriptional regulator
I6G68_02050	COG2022	thiamine diphosphate biosynthetic process
I6G68_02060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_02065	COG2390	Transcriptional regulator
I6G68_02070	COG4989	oxidoreductase activity
I6G68_02085	COG3414	Phosphotransferase system galactitol-specific IIB component
I6G68_02090	COG3775	system Galactitol-specific IIC component
I6G68_02095	COG1063	alcohol dehydrogenase
I6G68_02105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_02115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G68_02130	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_02135	COG3730	PTS system glucitol sorbitol-specific
I6G68_02140	COG3732	PTS system glucitol sorbitol-specific
I6G68_02150	COG0693	protein deglycase activity
I6G68_02155	COG2070	2-Nitropropane dioxygenase
I6G68_02165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6G68_02170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G68_02185	COG1942	4-Oxalocrotonate Tautomerase
I6G68_02230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G68_02235	COG0420	3'-5' exonuclease activity
I6G68_02240	COG0419	ATPase involved in DNA repair
I6G68_02255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6G68_02260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G68_02265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G68_02275	COG0492	ferredoxin-NADP+ reductase activity
I6G68_02295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G68_02305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G68_02310	COG1481	regulation of sporulation
I6G68_02325	COG0745	RESPONSE REGULATOR receiver
I6G68_02330	COG5002	protein histidine kinase activity
I6G68_02330	COG3850	Histidine kinase
I6G68_02340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G68_02350	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_02365	COG3022	response to hydroperoxide
I6G68_02370	COG1263	PTS System
I6G68_02370	COG2190	(PTS) system
I6G68_02370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_02375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G68_02380	COG3189	MarR family transcriptional regulator
I6G68_02395	COG0366	Alpha amylase catalytic
I6G68_02400	COG0561	phosphatase activity
I6G68_02410	COG4684	Psort location CytoplasmicMembrane, score
I6G68_02415	COG1187	pseudouridine synthase activity
I6G68_02430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G68_02435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G68_02445	COG0215	cysteine-tRNA ligase activity
I6G68_02450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G68_02455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G68_02460	COG3688	RNA-binding protein containing a PIN domain
I6G68_02475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G68_02480	COG0250	Participates in transcription elongation, termination and antitermination
I6G68_02490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G68_02495	COG0081	regulation of translation
I6G68_02500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G68_02510	COG1609	Transcriptional regulator
I6G68_02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G68_02525	COG2813	Specifically methylates the guanine in position
I6G68_02530	COG4175	Glycine betaine
I6G68_02530	COG3448	diguanylate cyclase activity
I6G68_02555	COG2848	UPF0210 protein
I6G68_02560	COG0584	glycerophosphoryl diester phosphodiesterase
I6G68_02565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G68_02575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G68_02585	COG2096	Adenosyltransferase
I6G68_02635	COG1131	(ABC) transporter
I6G68_02645	COG1230	cation diffusion facilitator family transporter
I6G68_02650	COG4463	regulation of RNA biosynthetic process
I6G68_02655	COG0542	response to heat
I6G68_02665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G68_02670	COG0590	tRNA wobble adenosine to inosine editing
I6G68_02680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G68_02690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G68_02700	COG0470	DNA polymerase III
I6G68_02710	COG4467	Involved in initiation control of chromosome replication
I6G68_02715	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G68_02725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G68_02735	COG1970	mechanosensitive ion channel activity
I6G68_02740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G68_02750	COG0436	Aminotransferase
I6G68_02755	COG1078	dGTPase activity
I6G68_02760	COG0095	Lipoate-protein ligase
I6G68_02770	COG3343	RNA polymerase activity
I6G68_02775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G68_02780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G68_02785	COG0254	rRNA binding
I6G68_02790	COG3764	Sortase (surface protein transpeptidase)
I6G68_02805	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G68_02810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G68_02820	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G68_02825	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6G68_02840	COG0789	Transcriptional regulator
I6G68_02850	COG1131	(ABC) transporter
I6G68_02860	COG1253	flavin adenine dinucleotide binding
I6G68_02885	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6G68_02890	COG0463	Glycosyl transferase, family 2
I6G68_02920	COG0322	excinuclease ABC activity
I6G68_02940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G68_02945	COG0193	aminoacyl-tRNA hydrolase activity
I6G68_02950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G68_02955	COG2244	polysaccharide biosynthetic process
I6G68_02960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G68_02970	COG1098	S1 RNA binding domain
I6G68_02975	COG0037	tRNA processing
I6G68_02980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G68_02985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G68_02990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G68_03000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G68_03005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G68_03015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G68_03020	COG0049	tRNA binding
I6G68_03025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G68_03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G68_03040	COG0051	transcription antitermination factor activity, RNA binding
I6G68_03045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G68_03055	COG0089	rRNA binding
I6G68_03060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G68_03065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G68_03080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G68_03085	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G68_03090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G68_03095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G68_03105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G68_03110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G68_03115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G68_03125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G68_03130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G68_03135	COG1841	ribosomal large subunit assembly
I6G68_03140	COG0200	Binds to the 23S rRNA
I6G68_03155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G68_03160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G68_03170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G68_03175	COG0202	RNA polymerase activity
I6G68_03180	COG0203	ribosomal protein L17
I6G68_03190	COG1122	ATPase activity
I6G68_03195	COG1122	ATPase activity
I6G68_03205	COG0101	tRNA pseudouridine synthase activity
I6G68_03220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G68_03250	COG2814	Major facilitator Superfamily
I6G68_03255	COG1902	pentaerythritol trinitrate reductase activity
I6G68_03260	COG1597	lipid kinase activity
I6G68_03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G68_03280	COG0517	IMP dehydrogenase activity
I6G68_03280	COG1125	glycine betaine transport
I6G68_03300	COG0564	pseudouridine synthase activity
I6G68_03310	COG0604	alcohol dehydrogenase
I6G68_03315	COG0402	S-adenosylhomocysteine deaminase activity
I6G68_03335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G68_03340	COG0668	transmembrane transport
I6G68_03380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G68_03405	COG2137	regulation of response to DNA damage stimulus
I6G68_03410	COG1194	a g-specific adenine glycosylase
I6G68_03425	COG1523	belongs to the glycosyl hydrolase 13 family
I6G68_03430	COG4129	membrane
I6G68_03435	COG0735	belongs to the Fur family
I6G68_03440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G68_03535	COG2059	Chromate
I6G68_03565	COG1653	transport
I6G68_03570	COG1653	transport
I6G68_03580	COG0395	ABC-type sugar transport system, permease component
I6G68_03585	COG3842	ATPase activity
I6G68_03590	COG1653	transport
I6G68_03650	COG0517	IMP dehydrogenase activity
I6G68_03650	COG0516	GMP reductase activity
I6G68_03655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G68_03660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_03665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G68_03670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G68_03675	COG3679	Belongs to the UPF0342 family
I6G68_03680	COG0420	3'-5' exonuclease activity
I6G68_03685	COG4717	serine-type aminopeptidase activity
I6G68_03690	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G68_03695	COG1442	glycosyl transferase family 8
I6G68_03710	COG0537	adenosine 5'-monophosphoramidase activity
I6G68_03715	COG1131	(ABC) transporter
I6G68_03730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G68_03740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_03750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G68_03755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G68_03775	COG0495	leucyl-tRNA aminoacylation
I6G68_03785	COG1126	abc transporter atp-binding protein
I6G68_03790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_03795	COG0765	amino acid transport
I6G68_03810	COG2244	polysaccharide biosynthetic process
I6G68_03815	COG1640	4-alpha-glucanotransferase
I6G68_03825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G68_03835	COG1733	regulation of RNA biosynthetic process
I6G68_03840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G68_03845	COG0072	phenylalanine-tRNA ligase activity
I6G68_03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_03850	COG1115	amino acid carrier protein
I6G68_03855	COG0280	phosphate acetyltransferase
I6G68_03875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G68_03880	COG4475	Protein of unknown function (DUF436)
I6G68_03885	COG0802	atpase or kinase
I6G68_03900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G68_03905	COG1122	ATPase activity
I6G68_03910	COG0406	alpha-ribazole phosphatase activity
I6G68_03930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G68_03930	COG1116	anion transmembrane transporter activity
I6G68_03950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G68_03960	COG3579	cysteine-type endopeptidase activity
I6G68_03965	COG0577	efflux transmembrane transporter activity
I6G68_03970	COG1136	(ABC) transporter
I6G68_03975	COG3949	Membrane
I6G68_03995	COG1132	(ABC) transporter
I6G68_04005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G68_04015	COG1191	sigma factor activity
I6G68_04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_04055	COG2190	(PTS) system
I6G68_04055	COG1263	PTS System
I6G68_04080	COG0588	phosphoglycerate mutase activity
I6G68_04085	COG0588	phosphoglycerate mutase activity
I6G68_04090	COG0431	NADPH-dependent FMN reductase
I6G68_04100	COG0028	Belongs to the TPP enzyme family
I6G68_04110	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G68_04110	COG2918	glutathione biosynthetic process
I6G68_04115	COG3842	ATPase activity
I6G68_04120	COG1175	transmembrane transport
I6G68_04125	COG0395	ABC-type sugar transport system, permease component
I6G68_04150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G68_04160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G68_04180	COG0431	NADPH-dependent FMN reductase
I6G68_04185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G68_04195	COG1464	Belongs to the NlpA lipoprotein family
I6G68_04235	COG1073	alpha beta
I6G68_04245	COG0653	protein targeting
I6G68_04255	COG1442	glycosyl transferase family 8
I6G68_04255	COG1216	Glycosyl transferase, family 2
I6G68_04270	COG1045	serine acetyltransferase
I6G68_04275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G68_04280	COG1304	FMN binding
I6G68_04295	COG0083	homoserine kinase activity
I6G68_04300	COG0519	Catalyzes the synthesis of GMP from XMP
I6G68_04300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G68_04325	COG1363	Peptidase, m42
I6G68_04335	COG0596	Alpha beta hydrolase
I6G68_04340	COG1720	tRNA m6t6A37 methyltransferase activity
I6G68_04360	COG1136	(ABC) transporter
I6G68_04360	COG0577	efflux transmembrane transporter activity
I6G68_04375	COG1263	PTS System
I6G68_04375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_04395	COG3118	belongs to the thioredoxin family
I6G68_04405	COG1803	Methylglyoxal synthase
I6G68_04410	COG0786	glutamate:sodium symporter activity
I6G68_04420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G68_04425	COG0622	Phosphoesterase
I6G68_04430	COG0668	transmembrane transport
I6G68_04440	COG4980	gas vesicle protein
I6G68_04445	COG1394	ATPase activity, coupled to movement of substances
I6G68_04475	COG1269	ATP hydrolysis coupled proton transport
I6G68_04490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G68_04495	COG1459	type II secretion system
I6G68_04500	COG4537	Required for transformation and DNA binding
I6G68_04525	COG0006	proline dipeptidase activity
I6G68_04530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G68_04540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G68_04545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G68_04550	COG1570	exodeoxyribonuclease VII activity
I6G68_04565	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G68_04570	COG0497	DNA recombination
I6G68_04575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G68_04580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G68_04605	COG3976	FMN-binding domain protein
I6G68_04605	COG1053	succinate dehydrogenase
I6G68_04610	COG1316	TRANSCRIPTIONal
I6G68_04615	COG3944	biosynthesis protein
I6G68_04620	COG0489	protein tyrosine kinase activity
I6G68_04625	COG4464	protein tyrosine phosphatase activity
I6G68_04635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G68_04650	COG1086	Polysaccharide biosynthesis protein
I6G68_04675	COG1216	Glycosyl transferase, family 2
I6G68_04675	COG1442	glycosyl transferase family 8
I6G68_04680	COG1215	transferase activity, transferring glycosyl groups
I6G68_04685	COG2244	polysaccharide biosynthetic process
I6G68_04775	COG2326	polyphosphate kinase activity
I6G68_04780	COG3620	sequence-specific DNA binding
I6G68_04790	COG0308	aminopeptidase N
I6G68_04805	COG0561	phosphatase activity
I6G68_04815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G68_04830	COG1295	ribonuclease BN
I6G68_04835	COG0772	Belongs to the SEDS family
I6G68_04840	COG1393	Belongs to the ArsC family
I6G68_04855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G68_04860	COG3590	peptidase
I6G68_04865	COG4166	transmembrane transport
I6G68_04870	COG4166	transmembrane transport
I6G68_04875	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G68_04880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6G68_04885	COG0018	arginyl-trna synthetase
I6G68_04915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_04930	COG2084	Dehydrogenase
I6G68_04955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G68_04960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G68_04965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G68_04970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G68_04975	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G68_04980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G68_04985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G68_04990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G68_04995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G68_05000	COG0138	bifunctional purine biosynthesis protein purh
I6G68_05005	COG0151	Belongs to the GarS family
I6G68_05010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G68_05025	COG2321	neutral zinc metallopeptidase
I6G68_05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_05040	COG2183	response to ionizing radiation
I6G68_05050	COG0039	L-malate dehydrogenase activity
I6G68_05080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G68_05085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G68_05100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G68_05105	COG1104	cysteine desulfurase activity
I6G68_05115	COG0482	sulfurtransferase activity
I6G68_05120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G68_05130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G68_05135	COG4472	Bacterial protein of unknown function (DUF965)
I6G68_05145	COG3906	Belongs to the UPF0473 family
I6G68_05150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G68_05155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G68_05160	COG1114	Component of the transport system for branched-chain amino acids
I6G68_05175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G68_05180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G68_05185	COG2070	2-Nitropropane dioxygenase
I6G68_05190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G68_05200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G68_05210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G68_05215	COG0439	Biotin carboxylase
I6G68_05220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G68_05225	COG0825	malonyl-CoA metabolic process
I6G68_05235	COG0328	RNA-DNA hybrid ribonuclease activity
I6G68_05240	COG3976	FMN-binding domain protein
I6G68_05240	COG1053	succinate dehydrogenase
I6G68_05255	COG1053	succinate dehydrogenase
I6G68_05255	COG3976	FMN-binding domain protein
I6G68_05260	COG3949	Membrane
I6G68_05270	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_05280	COG0116	Belongs to the methyltransferase superfamily
I6G68_05290	COG3599	regulation of cell shape
I6G68_05300	COG2264	protein methyltransferase activity
I6G68_05305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G68_05310	COG1490	D-aminoacyl-tRNA deacylase activity
I6G68_05320	COG0124	histidyl-tRNA synthetase
I6G68_05325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G68_05340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G68_05345	COG0735	belongs to the Fur family
I6G68_05355	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G68_05360	COG3845	ABC transporter
I6G68_05365	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G68_05370	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G68_05385	COG1610	YqeY-like protein
I6G68_05390	COG1702	phosphate starvation-inducible protein PhoH
I6G68_05395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G68_05405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G68_05410	COG1381	Involved in DNA repair and RecF pathway recombination
I6G68_05415	COG0752	glycyl-tRNA synthetase alpha subunit
I6G68_05420	COG0751	glycine-tRNA ligase activity
I6G68_05435	COG4221	oxidoreductase activity
I6G68_05440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G68_05440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G68_05445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_05455	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6G68_05465	COG2131	deaminase
I6G68_05470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G68_05475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G68_05480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G68_05485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G68_05490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G68_05510	COG1597	lipid kinase activity
I6G68_05515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G68_05515	COG0392	lysyltransferase activity
I6G68_05535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G68_05545	COG2832	Protein of unknown function (DUF454)
I6G68_05550	COG3001	Fructosamine kinase
I6G68_05555	COG0561	phosphatase activity
I6G68_05575	COG2032	superoxide dismutase activity
I6G68_05595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G68_05645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G68_05650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G68_05655	COG2610	gluconate transmembrane transporter activity
I6G68_05665	COG1737	Transcriptional regulator
I6G68_05670	COG1116	anion transmembrane transporter activity
I6G68_05675	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6G68_05685	COG1227	inorganic diphosphatase activity
I6G68_05690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G68_05695	COG0187	DNA topoisomerase II activity
I6G68_05700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G68_05705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G68_05715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G68_05720	COG0758	DNA mediated transformation
I6G68_05725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G68_05740	COG3409	Peptidoglycan-binding domain 1 protein
I6G68_05740	COG0793	Belongs to the peptidase S41A family
I6G68_05745	COG4479	Belongs to the UPF0346 family
I6G68_05755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G68_05765	COG0488	(ABC) transporter
I6G68_05770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G68_05780	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G68_05790	COG0481	GTPase activity
I6G68_05795	COG0484	heat shock protein binding
I6G68_05810	COG1420	regulation of RNA biosynthetic process
I6G68_05815	COG0196	riboflavin kinase activity
I6G68_05825	COG0514	ATP-dependent DNA helicase (RecQ)
I6G68_05835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_05840	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6G68_05850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G68_05865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G68_05870	COG0195	Participates in both transcription termination and antitermination
I6G68_05895	COG2176	DNA-directed DNA polymerase activity
I6G68_05900	COG0750	zinc metalloprotease
I6G68_05905	COG4589	Belongs to the CDS family
I6G68_05910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G68_05920	COG0528	UMP kinase activity
I6G68_05925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G68_05930	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G68_05945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G68_05950	COG0183	Belongs to the thiolase family
I6G68_05960	COG2610	gluconate transmembrane transporter activity
I6G68_05965	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_05970	COG0583	DNA-binding transcription factor activity
I6G68_05975	COG1024	Enoyl-CoA hydratase
I6G68_05980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G68_05985	COG1687	branched-chain amino acid
I6G68_05990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G68_05995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G68_06015	COG0204	Acyl-transferase
I6G68_06020	COG3763	UPF0154 protein
I6G68_06025	COG0564	pseudouridine synthase activity
I6G68_06030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G68_06045	COG1074	ATP-dependent DNA helicase activity
I6G68_06050	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6G68_06055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G68_06075	COG0297	glycogen (starch) synthase activity
I6G68_06080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G68_06095	COG0346	lactoylglutathione lyase activity
I6G68_06105	COG1307	EDD domain protein, DegV family
I6G68_06125	COG1132	(ABC) transporter
I6G68_06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G68_06150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G68_06155	COG0167	dihydroorotate dehydrogenase activity
I6G68_06165	COG0540	Belongs to the ATCase OTCase family
I6G68_06175	COG0505	Belongs to the CarA family
I6G68_06180	COG1126	abc transporter atp-binding protein
I6G68_06185	COG0765	amino acid transport
I6G68_06195	COG1792	Involved in formation and maintenance of cell shape
I6G68_06205	COG0527	aspartate kinase activity
I6G68_06210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G68_06215	COG0358	DNA primase activity
I6G68_06220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G68_06230	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G68_06235	COG3331	DNA recombination
I6G68_06245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G68_06255	COG3682	Transcriptional regulator
I6G68_06260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G68_06265	COG0561	phosphatase activity
I6G68_06270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G68_06280	COG0488	(ABC) transporter
I6G68_06285	COG1126	abc transporter atp-binding protein
I6G68_06290	COG0765	amino acid transport
I6G68_06295	COG0765	amino acid transport
I6G68_06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_06315	COG1132	(ABC) transporter
I6G68_06320	COG0628	permease
I6G68_06325	COG1072	(Pantothenic acid kinase))
I6G68_06335	COG4841	protein insertion into membrane
I6G68_06355	COG1272	protein, Hemolysin III
I6G68_06360	COG5503	Protein of unknown function (DUF1447)
I6G68_06365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G68_06375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G68_06390	COG0009	L-threonylcarbamoyladenylate synthase
I6G68_06395	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G68_06400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G68_06410	COG3442	glutamine amidotransferase
I6G68_06415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G68_06420	COG0628	permease
I6G68_06425	COG2706	6-phosphogluconolactonase activity
I6G68_06430	COG1968	undecaprenyl-diphosphatase activity
I6G68_06435	COG0686	Belongs to the AlaDH PNT family
I6G68_06440	COG1748	Saccharopine dehydrogenase
I6G68_06445	COG0019	diaminopimelate decarboxylase activity
I6G68_06450	COG0704	Plays a role in the regulation of phosphate uptake
I6G68_06455	COG2814	Major facilitator Superfamily
I6G68_06460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G68_06485	COG2207	Transcriptional regulator
I6G68_06485	COG1917	Cupin 2, conserved barrel domain protein
I6G68_06490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G68_06495	COG0557	exoribonuclease II activity
I6G68_06510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G68_06525	COG0647	UMP catabolic process
I6G68_06530	COG4470	Protein conserved in bacteria
I6G68_06535	COG0148	phosphopyruvate hydratase activity
I6G68_06550	COG2390	Transcriptional regulator
I6G68_06555	COG0740	serine-type endopeptidase activity
I6G68_06575	COG1464	Belongs to the NlpA lipoprotein family
I6G68_06580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G68_06580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_06580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G68_06585	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G68_06590	COG1349	DNA-binding transcription factor activity
I6G68_06730	COG0166	Belongs to the GPI family
I6G68_06735	COG1098	S1 RNA binding domain
I6G68_06740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G68_06745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6G68_06755	COG3935	DnaD domain protein
I6G68_06780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G68_06795	COG1160	GTP binding
I6G68_06800	COG0539	negative regulation of cytoplasmic translation
I6G68_06815	COG0514	ATP-dependent DNA helicase (RecQ)
I6G68_06830	COG4372	Transposase
I6G68_06840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G68_06845	COG1187	pseudouridine synthase activity
I6G68_06850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G68_06855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G68_06875	COG3344	reverse transcriptase
I6G68_06885	COG2996	Protein conserved in bacteria
I6G68_06895	COG0205	6-phosphofructokinase activity
I6G68_06900	COG0587	DNA-directed DNA polymerase activity
I6G68_06905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G68_06910	COG2255	four-way junction helicase activity
I6G68_06925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G68_06930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G68_07070	COG0582	viral genome integration into host DNA
I6G68_07080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G68_07085	COG1546	Belongs to the CinA family
I6G68_07085	COG1058	Belongs to the CinA family
I6G68_07090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G68_07095	COG1280	lysine exporter protein (LysE YggA)
I6G68_07095	COG1674	ftsk spoiiie
I6G68_07100	COG1254	Belongs to the acylphosphatase family
I6G68_07105	COG0706	membrane insertase activity
I6G68_07110	COG0745	RESPONSE REGULATOR receiver
I6G68_07115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G68_07130	COG1104	cysteine desulfurase activity
I6G68_07135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6G68_07140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G68_07145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G68_07155	COG0494	nUDIX hydrolase
I6G68_07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_07170	COG1278	Cold shock
I6G68_07175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G68_07180	COG3599	regulation of cell shape
I6G68_07185	COG2302	S4 RNA-binding domain
I6G68_07190	COG0762	integral membrane protein
I6G68_07195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G68_07205	COG0849	cell division
I6G68_07210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G68_07230	COG0768	penicillin binding
I6G68_07265	COG1323	Belongs to the UPF0348 family
I6G68_07270	COG2226	methyltransferase
I6G68_07275	COG0799	negative regulation of ribosome biogenesis
I6G68_07280	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G68_07285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G68_07290	COG1534	Rna-binding protein
I6G68_07295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G68_07300	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G68_07305	COG0083	homoserine kinase activity
I6G68_07310	COG0460	homoserine dehydrogenase
I6G68_07315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G68_07325	COG0438	transferase activity, transferring glycosyl groups
I6G68_07340	COG0542	response to heat
I6G68_07345	COG0517	IMP dehydrogenase activity
I6G68_07345	COG0516	GMP reductase activity
I6G68_07350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G68_07360	COG0765	amino acid transport
I6G68_07365	COG1394	ATPase activity, coupled to movement of substances
I6G68_07370	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6G68_07375	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6G68_07385	COG1527	subunit (C
I6G68_07395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G68_07400	COG1269	ATP hydrolysis coupled proton transport
I6G68_07415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G68_07420	COG2239	Acts as a magnesium transporter
I6G68_07425	COG0564	pseudouridine synthase activity
I6G68_07450	COG0180	Tryptophanyl-tRNA synthetase
I6G68_07455	COG1393	Belongs to the ArsC family
I6G68_07460	COG4862	establishment of competence for transformation
I6G68_07480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_07485	COG0783	Belongs to the Dps family
I6G68_07490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G68_07500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G68_07510	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6G68_07520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G68_07525	COG1484	DNA-dependent DNA replication
I6G68_07530	COG3611	Membrane attachment protein
I6G68_07535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G68_07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G68_07550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G68_07550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G68_07560	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_07560	COG1388	LysM domain
I6G68_07565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G68_07575	COG2003	Belongs to the UPF0758 family
I6G68_07580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G68_07585	COG0525	valine-tRNA ligase activity
I6G68_07590	COG2094	Belongs to the DNA glycosylase MPG family
I6G68_07595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G68_07600	COG1940	carbohydrate kinase activity
I6G68_07605	COG0457	Tetratricopeptide repeat
I6G68_07605	COG0705	Rhomboid family
I6G68_07610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_07625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G68_07630	COG0768	penicillin binding
I6G68_07640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G68_07650	COG0513	Belongs to the DEAD box helicase family
I6G68_07655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G68_07660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G68_07665	COG4109	DRTGG domain
I6G68_07685	COG0343	queuine tRNA-ribosyltransferase activity
I6G68_07690	COG0542	response to heat
I6G68_07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G68_07705	COG0022	dehydrogenase e1 component
I6G68_07710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G68_07715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_07725	COG2070	2-Nitropropane dioxygenase
I6G68_07730	COG0583	DNA-binding transcription factor activity
I6G68_07740	COG1024	Enoyl-CoA hydratase
I6G68_07745	COG3426	butyrate kinase activity
I6G68_07750	COG0280	phosphate acetyltransferase
I6G68_07755	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_07760	COG4221	oxidoreductase activity
I6G68_07765	COG0583	DNA-binding transcription factor activity
I6G68_07785	COG0335	large ribosomal subunit rRNA binding
I6G68_07795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G68_07800	COG1837	Belongs to the UPF0109 family
I6G68_07805	COG0228	four-way junction DNA binding
I6G68_07815	COG4864	UPF0365 protein
I6G68_07825	COG1132	(ABC) transporter
I6G68_07840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G68_07850	COG0552	protein localization to endoplasmic reticulum
I6G68_07855	COG0561	phosphatase activity
I6G68_07860	COG1196	nuclear chromosome segregation
I6G68_07865	COG0571	ribonuclease III activity
I6G68_07870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G68_07875	COG0416	fatty acid biosynthetic process
I6G68_07880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G68_07885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G68_07890	COG1461	Dihydroxyacetone kinase
I6G68_07895	COG1302	Protein conserved in bacteria
I6G68_07900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G68_07910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_07915	COG1162	GTPase activity
I6G68_07920	COG0515	serine threonine protein kinase
I6G68_07920	COG2815	serine threonine protein kinase
I6G68_07930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G68_07930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G68_07935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G68_07940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G68_07945	COG1758	RNA polymerase activity
I6G68_07950	COG0194	GDP metabolic process
I6G68_07960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G68_07975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G68_07980	COG3344	reverse transcriptase
I6G68_07985	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G68_07990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G68_07995	COG0671	phosphoesterase, PA-phosphatase related
I6G68_08005	COG0268	Binds directly to 16S ribosomal RNA
I6G68_08015	COG2333	competence protein COMEC
I6G68_08015	COG0658	competence protein
I6G68_08020	COG1596	polysaccharide export
I6G68_08020	COG1555	photosystem II stabilization
I6G68_08025	COG0742	ribosomal rna small subunit methyltransferase
I6G68_08035	COG3344	reverse transcriptase
I6G68_08045	COG4471	UPF0298 protein
I6G68_08050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G68_08055	COG0772	Belongs to the SEDS family
I6G68_08060	COG1217	gtp-binding protein TYPA
I6G68_08065	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_08070	COG4476	Belongs to the UPF0223 family
I6G68_08075	COG1187	pseudouridine synthase activity
I6G68_08080	COG0765	amino acid transport
I6G68_08085	COG0765	amino acid transport
I6G68_08090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_08125	COG0242	peptide deformylase activity
I6G68_08135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G68_08140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G68_08145	COG2855	membrane
I6G68_08155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G68_08195	COG3425	synthase
I6G68_08200	COG4608	Belongs to the ABC transporter superfamily
I6G68_08205	COG0444	Belongs to the ABC transporter superfamily
I6G68_08210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G68_08215	COG0601	transmembrane transport
I6G68_08225	COG4166	transmembrane transport
I6G68_08230	COG4166	transmembrane transport
I6G68_08235	COG4166	transmembrane transport
I6G68_08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G68_08245	COG0006	proline dipeptidase activity
I6G68_08255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G68_08260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G68_08300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G68_08305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G68_08320	COG0489	protein tyrosine kinase activity
I6G68_08335	COG1051	belongs to the nudix hydrolase family
I6G68_08340	COG1307	EDD domain protein, DegV family
I6G68_08350	COG0516	GMP reductase activity
I6G68_08355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G68_08360	COG1316	TRANSCRIPTIONal
I6G68_08365	COG0024	Methionine aminopeptidase
I6G68_08375	COG0716	FMN binding
I6G68_08395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G68_08395	COG0463	Glycosyl transferase, family 2
I6G68_08405	COG1216	Glycosyl transferase, family 2
I6G68_08410	COG1216	Glycosyl transferase, family 2
I6G68_08415	COG1216	Glycosyl transferase, family 2
I6G68_08425	COG2089	acid synthase
I6G68_08430	COG1083	cytidylyl-transferase
I6G68_08460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_08465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G68_08470	COG1121	(ABC) transporter
I6G68_08475	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G68_08475	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G68_08480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G68_08485	COG4466	Protein conserved in bacteria
I6G68_08500	COG4555	ABC transporter
I6G68_08505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G68_08515	COG0084	hydrolase, TatD family'
I6G68_08520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_08520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_08530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G68_08545	COG2738	Putative neutral zinc metallopeptidase
I6G68_08565	COG0436	Aminotransferase
I6G68_08570	COG1522	sequence-specific DNA binding
I6G68_08580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G68_08585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G68_08590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G68_08610	COG5002	protein histidine kinase activity
I6G68_08615	COG0745	RESPONSE REGULATOR receiver
I6G68_08620	COG3942	CHAP domain
I6G68_08625	COG0038	chloride channel
I6G68_08640	COG1268	BioY protein
I6G68_08650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G68_08650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G68_08655	COG0561	phosphatase activity
I6G68_08675	COG1957	nucleoside hydrolase
I6G68_08695	COG0181	hydroxymethylbilane synthase activity
I6G68_08710	COG1492	cobalamin metabolic process
I6G68_08760	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6G68_08770	COG1797	cobyrinic acid a,c-diamide synthase activity
I6G68_08780	COG4166	transmembrane transport
I6G68_08790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6G68_08795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G68_08800	COG0406	alpha-ribazole phosphatase activity
I6G68_08805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G68_08810	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6G68_08825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G68_08830	COG0549	Belongs to the carbamate kinase family
I6G68_08845	COG0542	response to heat
I6G68_08850	COG1115	amino acid carrier protein
I6G68_08855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G68_08860	COG2207	Transcriptional regulator
I6G68_08870	COG1691	(AIR) carboxylase
I6G68_08875	COG1606	tRNA processing
I6G68_08880	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6G68_08885	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6G68_08900	COG0435	Glutathione S-transferase
I6G68_08915	COG2205	protein histidine kinase activity
I6G68_08925	COG1131	(ABC) transporter
I6G68_08930	COG0095	Lipoate-protein ligase
I6G68_08940	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G68_08940	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G68_08945	COG3250	beta-galactosidase activity
I6G68_08955	COG0569	domain protein
I6G68_08960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G68_08970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G68_08975	COG0581	inorganic phosphate transmembrane transporter activity
I6G68_08980	COG0573	inorganic phosphate transmembrane transporter activity
I6G68_08990	COG5002	protein histidine kinase activity
I6G68_08995	COG0745	RESPONSE REGULATOR receiver
I6G68_09005	COG0653	protein targeting
I6G68_09015	COG1040	competence protein
I6G68_09020	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G68_09025	COG1739	Uncharacterized protein family UPF0029
I6G68_09030	COG0800	Aldolase
I6G68_09035	COG1428	Deoxynucleoside kinase