locus-tag	class	description
AWM75_00005	COG3949	Membrane
AWM75_00015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM75_00020	COG1288	antiporter activity
AWM75_00035	COG0577	efflux transmembrane transporter activity
AWM75_00040	COG1136	(ABC) transporter
AWM75_00080	COG3842	ATPase activity
AWM75_00085	COG1349	DNA-binding transcription factor activity
AWM75_00100	COG1304	FMN binding
AWM75_00105	COG0277	FAD linked oxidase domain protein
AWM75_00115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWM75_00120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM75_00125	COG2070	2-Nitropropane dioxygenase
AWM75_00130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWM75_00140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM75_00145	COG0511	ligase activity, forming carbon-carbon bonds
AWM75_00150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWM75_00155	COG0439	Biotin carboxylase
AWM75_00160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWM75_00165	COG0825	malonyl-CoA metabolic process
AWM75_00200	COG0116	Belongs to the methyltransferase superfamily
AWM75_00210	COG3599	regulation of cell shape
AWM75_00220	COG2264	protein methyltransferase activity
AWM75_00225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWM75_00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM75_00235	COG1490	D-aminoacyl-tRNA deacylase activity
AWM75_00240	COG2247	cell wall binding repeat
AWM75_00240	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWM75_00250	COG0124	histidyl-tRNA synthetase
AWM75_00255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM75_00260	COG0616	signal peptide processing
AWM75_00270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM75_00275	COG0735	belongs to the Fur family
AWM75_00280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWM75_00285	COG1702	phosphate starvation-inducible protein PhoH
AWM75_00290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM75_00295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AWM75_00300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM75_00305	COG1381	Involved in DNA repair and RecF pathway recombination
AWM75_00310	COG0752	glycyl-tRNA synthetase alpha subunit
AWM75_00315	COG0751	glycine-tRNA ligase activity
AWM75_00325	COG1234	tRNA 3'-trailer cleavage
AWM75_00335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM75_00335	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM75_00340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM75_00345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWM75_00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWM75_00380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM75_00385	COG1349	DNA-binding transcription factor activity
AWM75_00390	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM75_00395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM75_00395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM75_00395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM75_00435	COG0019	diaminopimelate decarboxylase activity
AWM75_00445	COG0469	pyruvate kinase activity
AWM75_00450	COG1397	ADP-ribosylglycohydrolase
AWM75_00455	COG0288	reversible hydration of carbon dioxide
AWM75_00465	COG3485	protocatechuate 3,4-dioxygenase
AWM75_00470	COG2188	Transcriptional regulator
AWM75_00475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM75_00475	COG1263	PTS System
AWM75_00475	COG2190	(PTS) system
AWM75_00480	COG2723	6-phospho-beta-galactosidase activity
AWM75_00490	COG4152	abc transporter atp-binding protein
AWM75_00495	COG1668	transmembrane transport
AWM75_00510	COG0786	glutamate:sodium symporter activity
AWM75_00520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM75_00525	COG2233	PERMEase
AWM75_00535	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_00560	COG2246	polysaccharide biosynthetic process
AWM75_00585	COG1307	EDD domain protein, DegV family
AWM75_00590	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_00605	COG2326	polyphosphate kinase activity
AWM75_00645	COG3590	peptidase
AWM75_00655	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWM75_00665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM75_00675	COG0402	S-adenosylhomocysteine deaminase activity
AWM75_00680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWM75_00690	COG4974	Belongs to the 'phage' integrase family
AWM75_00700	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AWM75_00715	COG3328	transposase activity
AWM75_00740	COG1764	response to oxidative stress
AWM75_00750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM75_00765	COG1811	Na channel or pump
AWM75_00790	COG2385	sporulation resulting in formation of a cellular spore
AWM75_00790	COG2247	cell wall binding repeat
AWM75_00820	COG1902	pentaerythritol trinitrate reductase activity
AWM75_00835	COG0392	lysyltransferase activity
AWM75_00835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AWM75_00845	COG0588	phosphoglycerate mutase activity
AWM75_00855	COG1115	amino acid carrier protein
AWM75_00865	COG1268	BioY protein
AWM75_00885	COG2755	lipolytic protein G-D-S-L family
AWM75_00885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWM75_00910	COG2423	ornithine cyclodeaminase activity
AWM75_00915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM75_00920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM75_00925	COG1121	(ABC) transporter
AWM75_00930	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM75_00935	COG2217	Heavy metal translocating P-type atpase
AWM75_00975	COG1132	(ABC) transporter
AWM75_00985	COG1573	uracil-dna glycosylase
AWM75_01000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM75_01005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWM75_01010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWM75_01020	COG2851	Citrate transporter
AWM75_01025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM75_01055	COG1957	nucleoside hydrolase
AWM75_01080	COG0402	S-adenosylhomocysteine deaminase activity
AWM75_01105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AWM75_01115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM75_01120	COG0569	domain protein
AWM75_01125	COG1227	inorganic diphosphatase activity
AWM75_01150	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM75_01155	COG1957	nucleoside hydrolase
AWM75_01160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWM75_01170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM75_01175	COG0187	DNA topoisomerase II activity
AWM75_01185	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWM75_01195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM75_01200	COG0758	DNA mediated transformation
AWM75_01210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM75_01215	COG0793	Belongs to the peptidase S41A family
AWM75_01215	COG3409	Peptidoglycan-binding domain 1 protein
AWM75_01220	COG4479	Belongs to the UPF0346 family
AWM75_01230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM75_01235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWM75_01240	COG0488	(ABC) transporter
AWM75_01245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM75_01250	COG0481	GTPase activity
AWM75_01265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AWM75_01270	COG3118	belongs to the thioredoxin family
AWM75_01275	COG1193	negative regulation of DNA recombination
AWM75_01285	COG1966	Carbon starvation protein
AWM75_01290	COG3051	citrate lyase alpha subunit
AWM75_01300	COG3052	prosthetic group binding
AWM75_01305	COG0583	DNA-binding transcription factor activity
AWM75_01310	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AWM75_01315	COG3177	Filamentation induced by cAMP protein fic
AWM75_01335	COG2205	protein histidine kinase activity
AWM75_01340	COG0745	RESPONSE REGULATOR receiver
AWM75_01345	COG1131	(ABC) transporter
AWM75_01400	COG0435	Glutathione S-transferase
AWM75_01405	COG0346	lactoylglutathione lyase activity
AWM75_01425	COG0708	Exodeoxyribonuclease III
AWM75_01435	COG1473	amidohydrolase
AWM75_01440	COG1053	succinate dehydrogenase
AWM75_01440	COG3976	FMN-binding domain protein
AWM75_01440	COG0431	NADPH-dependent FMN reductase
AWM75_01470	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_01485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AWM75_01495	COG1454	alcohol dehydrogenase
AWM75_01495	COG1012	belongs to the aldehyde dehydrogenase family
AWM75_01500	COG1435	thymidine kinase activity
AWM75_01515	COG2183	response to ionizing radiation
AWM75_01525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM75_01540	COG0018	arginyl-trna synthetase
AWM75_01545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM75_01560	COG0009	L-threonylcarbamoyladenylate synthase
AWM75_01565	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM75_01570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWM75_01575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM75_01580	COG0628	permease
AWM75_01585	COG2706	6-phosphogluconolactonase activity
AWM75_01590	COG1263	PTS System
AWM75_01590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM75_01590	COG2190	(PTS) system
AWM75_01595	COG1968	undecaprenyl-diphosphatase activity
AWM75_01600	COG0527	aspartate kinase activity
AWM75_01610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM75_01615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM75_01630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM75_01640	COG0346	lactoylglutathione lyase activity
AWM75_01650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWM75_01665	COG0473	3-isopropylmalate dehydrogenase activity
AWM75_01670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWM75_01675	COG1064	alcohol dehydrogenase
AWM75_01685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AWM75_01685	COG3264	Mechanosensitive ion channel
AWM75_01695	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM75_01700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWM75_01705	COG0557	exoribonuclease II activity
AWM75_01720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWM75_01725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AWM75_01730	COG0148	phosphopyruvate hydratase activity
AWM75_01735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWM75_01740	COG0149	triose-phosphate isomerase activity
AWM75_01745	COG0126	phosphoglycerate kinase activity
AWM75_01760	COG0740	serine-type endopeptidase activity
AWM75_01800	COG3328	transposase activity
AWM75_01825	COG1720	tRNA m6t6A37 methyltransferase activity
AWM75_01855	COG0484	heat shock protein binding
AWM75_01860	COG0443	Heat shock 70 kDa protein
AWM75_01875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWM75_01880	COG0196	riboflavin kinase activity
AWM75_01885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWM75_01890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM75_01905	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM75_01910	COG0195	Participates in both transcription termination and antitermination
AWM75_01915	COG0779	Required for maturation of 30S ribosomal subunits
AWM75_01935	COG0750	zinc metalloprotease
AWM75_01940	COG4589	Belongs to the CDS family
AWM75_01945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM75_01960	COG0233	cytoplasmic translational termination
AWM75_01965	COG0528	UMP kinase activity
AWM75_01970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWM75_01975	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM75_01985	COG0204	Acyl-transferase
AWM75_01990	COG1132	(ABC) transporter
AWM75_02000	COG3763	UPF0154 protein
AWM75_02005	COG0564	pseudouridine synthase activity
AWM75_02010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM75_02020	COG1074	ATP-dependent DNA helicase activity
AWM75_02025	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM75_02030	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM75_02035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM75_02040	COG2384	SAM-dependent methyltransferase
AWM75_02055	COG0483	inositol monophosphate 1-phosphatase activity
AWM75_02060	COG0584	glycerophosphoryl diester phosphodiesterase
AWM75_02065	COG3842	ATPase activity
AWM75_02070	COG0395	ABC-type sugar transport system, permease component
AWM75_02075	COG1175	transmembrane transport
AWM75_02095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM75_02100	COG0497	DNA recombination
AWM75_02105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM75_02120	COG1570	exodeoxyribonuclease VII activity
AWM75_02125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM75_02130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM75_02140	COG0006	proline dipeptidase activity
AWM75_02175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM75_02190	COG1269	ATP hydrolysis coupled proton transport
AWM75_02210	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM75_02220	COG1394	ATPase activity, coupled to movement of substances
AWM75_02225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM75_02230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM75_02250	COG0217	transcriptional regulatory protein
AWM75_02255	COG1597	lipid kinase activity
AWM75_02260	COG1609	Transcriptional regulator
AWM75_02275	COG0668	transmembrane transport
AWM75_02285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM75_02290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AWM75_02295	COG1803	Methylglyoxal synthase
AWM75_02305	COG3119	arylsulfatase activity
AWM75_02310	COG3119	arylsulfatase activity
AWM75_02315	COG0280	phosphate acetyltransferase
AWM75_02335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM75_02340	COG1733	regulation of RNA biosynthetic process
AWM75_02350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM75_02355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM75_02360	COG1187	pseudouridine synthase activity
AWM75_02365	COG2244	polysaccharide biosynthetic process
AWM75_02375	COG0495	leucyl-tRNA aminoacylation
AWM75_02380	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM75_02380	COG1388	LysM domain
AWM75_02385	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM75_02395	COG1278	Cold shock
AWM75_02400	COG2003	Belongs to the UPF0758 family
AWM75_02410	COG0525	valine-tRNA ligase activity
AWM75_02415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM75_02420	COG1940	carbohydrate kinase activity
AWM75_02425	COG0705	Rhomboid family
AWM75_02425	COG0457	Tetratricopeptide repeat
AWM75_02430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM75_02445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWM75_02455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWM75_02465	COG0802	atpase or kinase
AWM75_02470	COG0513	Belongs to the DEAD box helicase family
AWM75_02475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWM75_02485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM75_02490	COG4109	DRTGG domain
AWM75_02515	COG0343	queuine tRNA-ribosyltransferase activity
AWM75_02530	COG4864	UPF0365 protein
AWM75_02540	COG0542	response to heat
AWM75_02550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM75_02555	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM75_02565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM75_02570	COG0730	response to heat
AWM75_02575	COG0335	large ribosomal subunit rRNA binding
AWM75_02585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWM75_02595	COG1837	Belongs to the UPF0109 family
AWM75_02600	COG0228	four-way junction DNA binding
AWM75_02610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM75_02615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWM75_02640	COG0552	protein localization to endoplasmic reticulum
AWM75_02650	COG1196	nuclear chromosome segregation
AWM75_02655	COG0571	ribonuclease III activity
AWM75_02660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM75_02665	COG0416	fatty acid biosynthetic process
AWM75_02670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM75_02675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM75_02680	COG1461	Dihydroxyacetone kinase
AWM75_02685	COG1302	Protein conserved in bacteria
AWM75_02690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM75_02695	COG1564	THIamine pyrophosphokinase
AWM75_02700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM75_02710	COG2815	serine threonine protein kinase
AWM75_02710	COG0515	serine threonine protein kinase
AWM75_02715	COG0631	protein serine/threonine phosphatase activity
AWM75_02720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM75_02720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM75_02725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM75_02730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM75_02750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWM75_02765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM75_02770	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM75_02775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWM75_02780	COG0671	phosphoesterase, PA-phosphatase related
AWM75_02785	COG0577	efflux transmembrane transporter activity
AWM75_02790	COG1136	(ABC) transporter
AWM75_02790	COG0577	efflux transmembrane transporter activity
AWM75_02810	COG0556	nucleotide-excision repair
AWM75_02815	COG3328	transposase activity
AWM75_02830	COG0268	Binds directly to 16S ribosomal RNA
AWM75_02835	COG1466	dna polymerase III delta subunit
AWM75_02840	COG2333	competence protein COMEC
AWM75_02840	COG0658	competence protein
AWM75_02845	COG1555	photosystem II stabilization
AWM75_02845	COG1596	polysaccharide export
AWM75_02855	COG0742	ribosomal rna small subunit methyltransferase
AWM75_02860	COG1597	lipid kinase activity
AWM75_02875	COG4471	UPF0298 protein
AWM75_02880	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWM75_02885	COG0772	Belongs to the SEDS family
AWM75_02890	COG4838	Belongs to the UPF0358 family
AWM75_02900	COG0483	inositol monophosphate 1-phosphatase activity
AWM75_02905	COG4476	Belongs to the UPF0223 family
AWM75_02910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM75_02945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWM75_02960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWM75_02965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWM75_02970	COG0440	acetolactate synthase activity
AWM75_02975	COG0028	Belongs to the TPP enzyme family
AWM75_02980	COG1119	ATPase activity
AWM75_02990	COG3328	transposase activity
AWM75_02995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWM75_03015	COG3425	synthase
AWM75_03020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM75_03025	COG1904	glucuronate isomerase
AWM75_03035	COG0800	Aldolase
AWM75_03045	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_03060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM75_03070	COG0516	GMP reductase activity
AWM75_03075	COG0006	proline dipeptidase activity
AWM75_03095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWM75_03115	COG0710	3-dehydroquinate dehydratase activity
AWM75_03120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM75_03145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM75_03150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM75_03165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM75_03170	COG0038	chloride channel
AWM75_03180	COG1940	carbohydrate kinase activity
AWM75_03195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AWM75_03220	COG0489	protein tyrosine kinase activity
AWM75_03230	COG4464	protein tyrosine phosphatase activity
AWM75_03240	COG0673	inositol 2-dehydrogenase activity
AWM75_03250	COG0673	inositol 2-dehydrogenase activity
AWM75_03255	COG0673	inositol 2-dehydrogenase activity
AWM75_03260	COG1917	Cupin 2, conserved barrel domain protein
AWM75_03260	COG2207	Transcriptional regulator
AWM75_03265	COG1307	EDD domain protein, DegV family
AWM75_03270	COG2211	Major facilitator Superfamily
AWM75_03285	COG0516	GMP reductase activity
AWM75_03295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWM75_03305	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM75_03310	COG1473	amidohydrolase
AWM75_03315	COG1671	Belongs to the UPF0178 family
AWM75_03325	COG0640	Transcriptional regulator
AWM75_03330	COG1363	Peptidase, m42
AWM75_03400	COG4708	membrane
AWM75_03405	COG1473	amidohydrolase
AWM75_03440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM75_03445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM75_03450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWM75_03470	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM75_03475	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM75_03480	COG0101	tRNA pseudouridine synthase activity
AWM75_03485	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWM75_03490	COG1122	ATPase activity
AWM75_03495	COG1122	ATPase activity
AWM75_03500	COG0203	ribosomal protein L17
AWM75_03505	COG0202	RNA polymerase activity
AWM75_03515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWM75_03520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWM75_03525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWM75_03540	COG0200	Binds to the 23S rRNA
AWM75_03545	COG1841	ribosomal large subunit assembly
AWM75_03550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM75_03555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM75_03560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWM75_03570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM75_03580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWM75_03585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM75_03590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM75_03595	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM75_03600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM75_03605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWM75_03610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWM75_03625	COG0089	rRNA binding
AWM75_03630	COG0088	Forms part of the polypeptide exit tunnel
AWM75_03635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM75_03650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM75_03655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM75_03660	COG1780	Probably involved in ribonucleotide reductase function
AWM75_03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM75_03670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM75_03675	COG0049	tRNA binding
AWM75_03680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM75_03685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM75_03690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM75_03700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM75_03705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM75_03715	COG0037	tRNA processing
AWM75_03720	COG1098	S1 RNA binding domain
AWM75_03730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM75_03735	COG2244	polysaccharide biosynthetic process
AWM75_03740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM75_03745	COG0193	aminoacyl-tRNA hydrolase activity
AWM75_03765	COG0039	L-malate dehydrogenase activity
AWM75_03775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM75_03780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWM75_03790	COG1408	metallophosphoesterase
AWM75_03795	COG0322	excinuclease ABC activity
AWM75_03800	COG2321	neutral zinc metallopeptidase
AWM75_03865	COG1253	flavin adenine dinucleotide binding
AWM75_03880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM75_03885	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWM75_03890	COG0736	holo-[acyl-carrier-protein] synthase activity
AWM75_03900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM75_03905	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM75_03925	COG2131	deaminase
AWM75_03935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM75_03940	COG1064	alcohol dehydrogenase
AWM75_03945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM75_03955	COG3343	RNA polymerase activity
AWM75_03965	COG0095	Lipoate-protein ligase
AWM75_03970	COG1078	dGTPase activity
AWM75_03975	COG0436	Aminotransferase
AWM75_03985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWM75_04005	COG2827	Endonuclease containing a URI domain
AWM75_04010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM75_04015	COG4467	Involved in initiation control of chromosome replication
AWM75_04030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWM75_04035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM75_04040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWM75_04045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM75_04055	COG1328	CTP reductase activity
AWM75_04060	COG0602	queuosine metabolic process
AWM75_04065	COG0514	ATP-dependent DNA helicase (RecQ)
AWM75_04070	COG2239	Acts as a magnesium transporter
AWM75_04085	COG1394	ATPase activity, coupled to movement of substances
AWM75_04090	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AWM75_04095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM75_04100	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AWM75_04115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM75_04120	COG1269	ATP hydrolysis coupled proton transport
AWM75_04130	COG0590	tRNA wobble adenosine to inosine editing
AWM75_04135	COG0363	glucosamine-6-phosphate deaminase activity
AWM75_04155	COG4463	regulation of RNA biosynthetic process
AWM75_04160	COG1073	alpha beta
AWM75_04165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM75_04215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM75_04235	COG4175	Glycine betaine
AWM75_04235	COG3448	diguanylate cyclase activity
AWM75_04240	COG2813	Specifically methylates the guanine in position
AWM75_04250	COG0222	ribosome binding
AWM75_04255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWM75_04265	COG0081	regulation of translation
AWM75_04270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AWM75_04275	COG0250	Participates in transcription elongation, termination and antitermination
AWM75_04280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWM75_04290	COG3688	RNA-binding protein containing a PIN domain
AWM75_04300	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM75_04305	COG0215	cysteine-tRNA ligase activity
AWM75_04310	COG1045	serine acetyltransferase
AWM75_04315	COG0058	SHG alpha-glucan phosphorylase activity
AWM75_04320	COG1640	4-alpha-glucanotransferase
AWM75_04325	COG0371	Dehydrogenase
AWM75_04370	COG3290	protein histidine kinase activity
AWM75_04375	COG3328	transposase activity
AWM75_04385	COG1464	Belongs to the NlpA lipoprotein family
AWM75_04395	COG1464	Belongs to the NlpA lipoprotein family
AWM75_04405	COG0662	Cupin 2, conserved barrel domain protein
AWM75_04410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM75_04415	COG4956	integral membrane protein (PIN domain superfamily)
AWM75_04420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM75_04425	COG0756	dUTP diphosphatase activity
AWM75_04440	COG1132	(ABC) transporter
AWM75_04445	COG1132	(ABC) transporter
AWM75_04460	COG0628	permease
AWM75_04470	COG0789	Transcriptional regulator
AWM75_04475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWM75_04485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWM75_04490	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWM75_04495	COG2376	Dihydroxyacetone kinase
AWM75_04500	COG1461	Dihydroxyacetone kinase
AWM75_04505	COG0129	dihydroxy-acid dehydratase activity
AWM75_04510	COG2217	Heavy metal translocating P-type atpase
AWM75_04515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM75_04530	COG1346	cytolysis
AWM75_04555	COG0628	permease
AWM75_04565	COG0569	domain protein
AWM75_04570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM75_04575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM75_04580	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM75_04600	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AWM75_04605	COG0305	Participates in initiation and elongation during chromosome replication
AWM75_04610	COG0359	binds to the 23S rRNA
AWM75_04625	COG0629	single-stranded DNA binding
AWM75_04635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM75_04640	COG0187	DNA topoisomerase II activity
AWM75_04645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM75_04670	COG3328	transposase activity
AWM75_04675	COG1191	sigma factor activity
AWM75_04680	COG0592	DNA-directed DNA polymerase activity
AWM75_04685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AWM75_04690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AWM75_04700	COG0706	membrane insertase activity
AWM75_04705	COG1847	R3H domain protein
AWM75_04710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM75_04715	COG0445	tRNA wobble uridine modification
AWM75_04720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM75_04725	COG0357	Ribosomal RNA small subunit methyltransferase G
AWM75_04730	COG1192	Involved in chromosome partitioning
AWM75_04735	COG1475	DNA binding
AWM75_04740	COG4481	Protein conserved in bacteria
AWM75_04745	COG0012	GTP binding
AWM75_04760	COG5002	protein histidine kinase activity
AWM75_04810	COG0277	FAD linked oxidase domain protein
AWM75_04815	COG0686	Belongs to the AlaDH PNT family
AWM75_04825	COG0589	response to stress
AWM75_04835	COG0626	cystathionine gamma-synthase activity
AWM75_04840	COG0583	DNA-binding transcription factor activity
AWM75_04865	COG1302	Protein conserved in bacteria
AWM75_04875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM75_04880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM75_04895	COG1187	pseudouridine synthase activity
AWM75_04925	COG1464	Belongs to the NlpA lipoprotein family
AWM75_04930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM75_04950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWM75_04965	COG0561	phosphatase activity
AWM75_04970	COG1051	belongs to the nudix hydrolase family
AWM75_04975	COG4684	Psort location CytoplasmicMembrane, score
AWM75_04980	COG1607	acyl-coa hydrolase
AWM75_04985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM75_04990	COG3764	Sortase (surface protein transpeptidase)
AWM75_05005	COG4224	UPF0291 protein
AWM75_05020	COG1122	ATPase activity
AWM75_05030	COG1214	PFAM Peptidase M22, glycoprotease
AWM75_05045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM75_05050	COG0488	(ABC) transporter
AWM75_05065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWM75_05070	COG0459	protein refolding
AWM75_05075	COG0431	NADPH-dependent FMN reductase
AWM75_05080	COG0765	amino acid transport
AWM75_05090	COG0765	amino acid transport
AWM75_05095	COG0165	Argininosuccinate lyase
AWM75_05100	COG0137	argininosuccinate synthase activity
AWM75_05105	COG0765	amino acid transport
AWM75_05115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM75_05120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM75_05130	COG1739	Uncharacterized protein family UPF0029
AWM75_05135	COG1307	EDD domain protein, DegV family
AWM75_05140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM75_05155	COG0653	protein targeting
AWM75_05160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM75_05165	COG0745	RESPONSE REGULATOR receiver
AWM75_05170	COG5002	protein histidine kinase activity
AWM75_05175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWM75_05180	COG0573	inorganic phosphate transmembrane transporter activity
AWM75_05185	COG0581	inorganic phosphate transmembrane transporter activity
AWM75_05190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM75_05195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWM75_05200	COG0420	3'-5' exonuclease activity
AWM75_05205	COG0419	ATPase involved in DNA repair
AWM75_05220	COG1950	PFAM Membrane protein of
AWM75_05225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWM75_05230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM75_05245	COG0492	ferredoxin-NADP+ reductase activity
AWM75_05250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM75_05255	COG1660	Displays ATPase and GTPase activities
AWM75_05265	COG1481	regulation of sporulation
AWM75_05270	COG0629	single-stranded DNA binding
AWM75_05275	COG0745	RESPONSE REGULATOR receiver
AWM75_05280	COG5002	protein histidine kinase activity
AWM75_05280	COG3850	Histidine kinase
AWM75_05290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM75_05295	COG2081	HI0933 family
AWM75_05320	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWM75_05330	COG0411	ABC transporter
AWM75_05340	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM75_05350	COG0210	DNA helicase
AWM75_05355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM75_05370	COG0154	amidase activity
AWM75_05375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM75_05380	COG4475	Protein of unknown function (DUF436)
AWM75_05385	COG0564	pseudouridine synthase activity
AWM75_05395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM75_05400	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_05410	COG0659	secondary active sulfate transmembrane transporter activity
AWM75_05415	COG0157	Belongs to the NadC ModD family
AWM75_05425	COG3620	sequence-specific DNA binding
AWM75_05440	COG1073	alpha beta
AWM75_05455	COG0697	spore germination
AWM75_05465	COG2197	response regulator
AWM75_05480	COG0653	protein targeting
AWM75_05485	COG2267	carboxylic ester hydrolase activity
AWM75_05490	COG0583	DNA-binding transcription factor activity
AWM75_05500	COG2326	polyphosphate kinase activity
AWM75_05515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM75_05520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWM75_05545	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM75_05550	COG1116	anion transmembrane transporter activity
AWM75_05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM75_05575	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM75_05575	COG1388	LysM domain
AWM75_05580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM75_05585	COG3830	Belongs to the UPF0237 family
AWM75_05590	COG2848	UPF0210 protein
AWM75_05595	COG0011	TIGRFAM Protein of
AWM75_05605	COG0435	Glutathione S-transferase
AWM75_05610	COG3022	response to hydroperoxide
AWM75_05615	COG1263	PTS System
AWM75_05615	COG2190	(PTS) system
AWM75_05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM75_05625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWM75_05635	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWM75_05645	COG0745	RESPONSE REGULATOR receiver
AWM75_05650	COG5002	protein histidine kinase activity
AWM75_05660	COG4853	Protein conserved in bacteria
AWM75_05670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM75_05675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM75_05680	COG2211	Major facilitator Superfamily
AWM75_05730	COG2738	Putative neutral zinc metallopeptidase
AWM75_05740	COG0174	glutamine synthetase
AWM75_05750	COG0436	Aminotransferase
AWM75_05755	COG2249	NAD(P)H dehydrogenase (quinone) activity
AWM75_05765	COG0704	Plays a role in the regulation of phosphate uptake
AWM75_05770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWM75_05790	COG1621	beta-fructofuranosidase activity
AWM75_05800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM75_05800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM75_05805	COG0084	hydrolase, TatD family'
AWM75_05815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM75_05820	COG4466	Protein conserved in bacteria
AWM75_05825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM75_05830	COG1121	(ABC) transporter
AWM75_05835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM75_05840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM75_05845	COG3307	-O-antigen
AWM75_05855	COG1215	transferase activity, transferring glycosyl groups
AWM75_05865	COG0438	transferase activity, transferring glycosyl groups
AWM75_05865	COG0297	glycogen (starch) synthase activity
AWM75_05875	COG1388	LysM domain
AWM75_05875	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM75_05880	COG2247	cell wall binding repeat
AWM75_05880	COG2385	sporulation resulting in formation of a cellular spore
AWM75_05895	COG2309	aminopeptidase activity
AWM75_05900	COG0716	FMN binding
AWM75_05910	COG0024	Methionine aminopeptidase
AWM75_05920	COG1316	TRANSCRIPTIONal
AWM75_05925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM75_05935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM75_05955	COG2137	regulation of response to DNA damage stimulus
AWM75_05960	COG1194	a g-specific adenine glycosylase
AWM75_05975	COG1523	belongs to the glycosyl hydrolase 13 family
AWM75_05985	COG0735	belongs to the Fur family
AWM75_05990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM75_06090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM75_06095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWM75_06100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM75_06105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM75_06110	COG3679	Belongs to the UPF0342 family
AWM75_06120	COG4717	serine-type aminopeptidase activity
AWM75_06145	COG0537	adenosine 5'-monophosphoramidase activity
AWM75_06150	COG1131	(ABC) transporter
AWM75_06155	COG4473	ABC transporter
AWM75_06160	COG0510	thiamine kinase activity
AWM75_06165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWM75_06175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM75_06175	COG0072	phenylalanine-tRNA ligase activity
AWM75_06185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM75_06210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM75_06235	COG0285	dihydrofolate synthase activity
AWM75_06240	COG1302	Protein conserved in bacteria
AWM75_06245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM75_06260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM75_06260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM75_06265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWM75_06270	COG0237	dephospho-CoA kinase activity
AWM75_06280	COG3611	Membrane attachment protein
AWM75_06285	COG1484	DNA-dependent DNA replication
AWM75_06300	COG1302	Protein conserved in bacteria
AWM75_06305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM75_06315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWM75_06320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AWM75_06325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWM75_06330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM75_06340	COG1464	Belongs to the NlpA lipoprotein family
AWM75_06350	COG4862	establishment of competence for transformation
AWM75_06355	COG1393	Belongs to the ArsC family
AWM75_06360	COG0180	Tryptophanyl-tRNA synthetase
AWM75_06370	COG1164	Oligoendopeptidase f
AWM75_06380	COG4116	CYTH
AWM75_06385	COG2357	RelA SpoT domain protein
AWM75_06390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWM75_06395	COG0564	pseudouridine synthase activity
AWM75_06400	COG2239	Acts as a magnesium transporter
AWM75_06425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM75_06430	COG0542	response to heat
AWM75_06435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM75_06440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWM75_06445	COG0438	transferase activity, transferring glycosyl groups
AWM75_06450	COG4703	Protein of unknown function (DUF1797)
AWM75_06455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM75_06460	COG0460	homoserine dehydrogenase
AWM75_06470	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWM75_06475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM75_06480	COG1534	Rna-binding protein
AWM75_06485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM75_06490	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWM75_06495	COG0799	negative regulation of ribosome biogenesis
AWM75_06500	COG2226	methyltransferase
AWM75_06505	COG1323	Belongs to the UPF0348 family
AWM75_06525	COG2001	Belongs to the MraZ family
AWM75_06550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWM75_06555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWM75_06560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM75_06575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM75_06580	COG0762	integral membrane protein
AWM75_06585	COG2302	S4 RNA-binding domain
AWM75_06590	COG3599	regulation of cell shape
AWM75_06595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM75_06605	COG2261	transglycosylase associated protein
AWM75_06610	COG3853	Toxic anion resistance protein (TelA)
AWM75_06620	COG0494	nUDIX hydrolase
AWM75_06630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWM75_06635	COG1335	isochorismatase
AWM75_06640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM75_06645	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM75_06650	COG1104	cysteine desulfurase activity
AWM75_06660	COG2514	catechol 2,3-dioxygenase activity
AWM75_06665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWM75_06670	COG0706	membrane insertase activity
AWM75_06675	COG1254	Belongs to the acylphosphatase family
AWM75_06680	COG1280	lysine exporter protein (LysE YggA)
AWM75_06680	COG1674	ftsk spoiiie
AWM75_06685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM75_06690	COG1546	Belongs to the CinA family
AWM75_06690	COG1058	Belongs to the CinA family
AWM75_06695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM75_06700	COG1418	mRNA catabolic process
AWM75_06705	COG1692	metallophosphoesterase
AWM75_06710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM75_06720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM75_06725	COG0632	four-way junction helicase activity
AWM75_06735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM75_06740	COG0587	DNA-directed DNA polymerase activity
AWM75_06745	COG0205	6-phosphofructokinase activity
AWM75_06760	COG0735	belongs to the Fur family
AWM75_06775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM75_06780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM75_06785	COG1187	pseudouridine synthase activity
AWM75_06805	COG0514	ATP-dependent DNA helicase (RecQ)
AWM75_06815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWM75_06820	COG0539	negative regulation of cytoplasmic translation
AWM75_06830	COG0776	regulation of translation
AWM75_06840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM75_06845	COG0617	tRNA 3'-terminal CCA addition
AWM75_06850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWM75_06850	COG1199	ATP-dependent helicase activity
AWM75_06870	COG1846	Transcriptional regulator
AWM75_06875	COG0737	Belongs to the 5'-nucleotidase family
AWM75_06880	COG4470	Protein conserved in bacteria
AWM75_06900	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM75_06905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM75_06910	COG1098	S1 RNA binding domain
AWM75_06915	COG0166	Belongs to the GPI family
AWM75_07045	COG3052	prosthetic group binding
AWM75_07060	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AWM75_07070	COG2851	Citrate transporter
AWM75_07080	COG0511	ligase activity, forming carbon-carbon bonds
AWM75_07085	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AWM75_07090	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AWM75_07095	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AWM75_07095	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AWM75_07115	COG0765	amino acid transport
AWM75_07120	COG1126	abc transporter atp-binding protein
AWM75_07130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWM75_07135	COG2868	ribosomal protein
AWM75_07145	COG0827	DNA restriction-modification system
AWM75_07150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWM75_07155	COG0589	response to stress
AWM75_07165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM75_07170	COG2918	glutathione biosynthetic process
AWM75_07170	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM75_07175	COG1104	cysteine desulfurase activity
AWM75_07190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM75_07195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM75_07200	COG4472	Bacterial protein of unknown function (DUF965)
AWM75_07210	COG3906	Belongs to the UPF0473 family
AWM75_07215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM75_07220	COG0572	uridine kinase
AWM75_07225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM75_07235	COG4585	Histidine kinase
AWM75_07240	COG2197	response regulator
AWM75_07245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWM75_07255	COG3527	Alpha-acetolactate decarboxylase
AWM75_07265	COG1272	protein, Hemolysin III
AWM75_07280	COG1307	EDD domain protein, DegV family
AWM75_07285	COG4841	protein insertion into membrane
AWM75_07290	COG4619	ABC transporter
AWM75_07295	COG0390	transport system, permease component
AWM75_07310	COG1811	Na channel or pump
AWM75_07315	COG2964	Protein conserved in bacteria
AWM75_07380	COG1132	(ABC) transporter
AWM75_07390	COG0488	(ABC) transporter
AWM75_07395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM75_07400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM75_07410	COG0561	phosphatase activity
AWM75_07415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM75_07440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM75_07445	COG3331	DNA recombination
AWM75_07450	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWM75_07460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWM75_07465	COG0358	DNA primase activity
AWM75_07470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM75_07480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM75_07485	COG1122	ATPase activity
AWM75_07500	COG3328	transposase activity
AWM75_07505	COG1304	FMN binding
AWM75_07520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AWM75_07535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM75_07540	COG2079	MmgE PrpD family protein
AWM75_07545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM75_07555	COG0765	amino acid transport
AWM75_07560	COG1126	abc transporter atp-binding protein
AWM75_07620	COG1126	abc transporter atp-binding protein
AWM75_07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM75_07630	COG1136	(ABC) transporter
AWM75_07630	COG0577	efflux transmembrane transporter activity
AWM75_07645	COG3328	transposase activity
AWM75_07655	COG0683	leucine binding
AWM75_07660	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWM75_07680	COG3328	transposase activity
AWM75_07690	COG2824	Alkylphosphonate utilization operon protein PhnA
AWM75_07700	COG3328	transposase activity
AWM75_07705	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM75_07705	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM75_07715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWM75_07720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWM75_07725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWM75_07730	COG0738	Major facilitator superfamily
AWM75_07755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM75_07765	COG0438	transferase activity, transferring glycosyl groups
AWM75_07775	COG1216	Glycosyl transferase, family 2
AWM75_07800	COG2089	acid synthase
AWM75_07815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWM75_07820	COG3328	transposase activity
AWM75_07900	COG3775	system Galactitol-specific IIC component
AWM75_07915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM75_07950	COG1028	Short-chain dehydrogenase reductase Sdr
AWM75_07960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM75_07965	COG1522	sequence-specific DNA binding
AWM75_07965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM75_07970	COG0135	phosphoribosylanthranilate isomerase activity
AWM75_07990	COG0095	Lipoate-protein ligase
AWM75_08010	COG2385	sporulation resulting in formation of a cellular spore
AWM75_08010	COG2247	cell wall binding repeat
AWM75_08015	COG2385	sporulation resulting in formation of a cellular spore
AWM75_08015	COG2247	cell wall binding repeat
AWM75_08030	COG1902	pentaerythritol trinitrate reductase activity
AWM75_08035	COG0583	DNA-binding transcription factor activity
AWM75_08050	COG1562	ergosterol biosynthetic process
AWM75_08070	COG0601	transmembrane transport
AWM75_08075	COG0601	transmembrane transport
AWM75_08080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM75_08085	COG0444	Belongs to the ABC transporter superfamily
AWM75_08090	COG1124	(ABC) transporter
AWM75_08105	COG0804	urea catabolic process
AWM75_08110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AWM75_08115	COG0830	nickel cation binding
AWM75_08125	COG0829	nickel cation binding
AWM75_08160	COG1940	carbohydrate kinase activity
AWM75_08175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM75_08195	COG0656	L-ascorbic acid biosynthetic process
AWM75_08205	COG3328	transposase activity
AWM75_08225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM75_08225	COG1263	PTS System
AWM75_08230	COG0366	Alpha amylase catalytic
AWM75_08240	COG0772	Belongs to the SEDS family
AWM75_08245	COG1393	Belongs to the ArsC family
AWM75_08255	COG0719	Fe-S assembly protein
AWM75_08260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWM75_08270	COG0719	Fe-S assembly protein
AWM75_08305	COG1857	crispr-associated protein
AWM75_08320	COG1518	maintenance of DNA repeat elements
AWM75_08360	COG2972	Histidine kinase
AWM75_08365	COG1263	PTS System
AWM75_08365	COG2190	(PTS) system
AWM75_08365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM75_08370	COG1301	dicarboxylic acid transport
AWM75_08400	COG1131	(ABC) transporter
AWM75_08445	COG0569	domain protein
AWM75_08490	COG0494	nUDIX hydrolase
AWM75_08495	COG0456	acetyltransferase
AWM75_08500	COG1609	Transcriptional regulator
AWM75_08505	COG2723	6-phospho-beta-galactosidase activity