locus-tag	class	description
AWM76_00010	COG0583	DNA-binding transcription factor activity
AWM76_00015	COG0626	cystathionine gamma-synthase activity
AWM76_00020	COG2514	catechol 2,3-dioxygenase activity
AWM76_00030	COG0039	L-malate dehydrogenase activity
AWM76_00040	COG0589	response to stress
AWM76_00060	COG1363	Peptidase, m42
AWM76_00135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM76_00140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM76_00155	COG0745	RESPONSE REGULATOR receiver
AWM76_00180	COG0012	GTP binding
AWM76_00185	COG4481	Protein conserved in bacteria
AWM76_00190	COG1475	DNA binding
AWM76_00195	COG1192	Involved in chromosome partitioning
AWM76_00200	COG0357	Ribosomal RNA small subunit methyltransferase G
AWM76_00205	COG0445	tRNA wobble uridine modification
AWM76_00210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM76_00220	COG0668	transmembrane transport
AWM76_00230	COG1847	R3H domain protein
AWM76_00235	COG0706	membrane insertase activity
AWM76_00255	COG0592	DNA-directed DNA polymerase activity
AWM76_00260	COG2501	S4 domain
AWM76_00265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM76_00270	COG0187	DNA topoisomerase II activity
AWM76_00275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM76_00280	COG0360	Binds together with S18 to 16S ribosomal RNA
AWM76_00285	COG0629	single-stranded DNA binding
AWM76_00290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWM76_00295	COG0346	lactoylglutathione lyase activity
AWM76_00300	COG0371	Dehydrogenase
AWM76_00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM76_00320	COG0359	binds to the 23S rRNA
AWM76_00325	COG0305	Participates in initiation and elongation during chromosome replication
AWM76_00330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWM76_00400	COG0582	viral genome integration into host DNA
AWM76_00410	COG1122	ATPase activity
AWM76_00420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWM76_00430	COG0693	protein deglycase activity
AWM76_00435	COG1428	Deoxynucleoside kinase
AWM76_00465	COG1346	cytolysis
AWM76_00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM76_00480	COG1418	mRNA catabolic process
AWM76_00485	COG1428	Deoxynucleoside kinase
AWM76_00490	COG0602	queuosine metabolic process
AWM76_00510	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM76_00515	COG2217	Heavy metal translocating P-type atpase
AWM76_00520	COG3316	Transposase and inactivated derivatives
AWM76_00530	COG3316	Transposase and inactivated derivatives
AWM76_00560	COG3041	Addiction module toxin RelE StbE family
AWM76_00580	COG3328	transposase activity
AWM76_00600	COG2963	transposase activity
AWM76_00630	COG1401	restriction endodeoxyribonuclease activity
AWM76_00650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWM76_00680	COG3316	Transposase and inactivated derivatives
AWM76_00685	COG1115	amino acid carrier protein
AWM76_00720	COG2217	Heavy metal translocating P-type atpase
AWM76_00725	COG0640	Transcriptional regulator
AWM76_00735	COG3328	transposase activity
AWM76_00745	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_00815	COG3328	transposase activity
AWM76_00840	COG1461	Dihydroxyacetone kinase
AWM76_00845	COG2376	Dihydroxyacetone kinase
AWM76_00850	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWM76_00855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWM76_00860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWM76_00865	COG0789	Transcriptional regulator
AWM76_00880	COG3715	PTS system
AWM76_00885	COG3716	PTS system mannose fructose sorbose family IID component
AWM76_00895	COG1482	cell wall glycoprotein biosynthetic process
AWM76_00900	COG2116	formate transmembrane transporter activity
AWM76_00935	COG0756	dUTP diphosphatase activity
AWM76_00940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM76_00945	COG4956	integral membrane protein (PIN domain superfamily)
AWM76_00950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM76_00970	COG1780	Probably involved in ribonucleotide reductase function
AWM76_00975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM76_00985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM76_00990	COG2233	PERMEase
AWM76_00995	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_01015	COG1174	glycine betaine transport
AWM76_01020	COG0517	IMP dehydrogenase activity
AWM76_01020	COG1125	glycine betaine transport
AWM76_01025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWM76_01030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM76_01045	COG1116	anion transmembrane transporter activity
AWM76_01055	COG3328	transposase activity
AWM76_01065	COG1464	Belongs to the NlpA lipoprotein family
AWM76_01075	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM76_01080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM76_01105	COG2610	gluconate transmembrane transporter activity
AWM76_01115	COG0250	Participates in transcription elongation, termination and antitermination
AWM76_01120	COG0704	Plays a role in the regulation of phosphate uptake
AWM76_01125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AWM76_01130	COG0081	regulation of translation
AWM76_01140	COG0222	ribosome binding
AWM76_01150	COG1121	(ABC) transporter
AWM76_01155	COG1321	iron dependent repressor
AWM76_01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM76_01160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM76_01165	COG2813	Specifically methylates the guanine in position
AWM76_01170	COG4175	Glycine betaine
AWM76_01170	COG3448	diguanylate cyclase activity
AWM76_01190	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM76_01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM76_01230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM76_01235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM76_01245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM76_01250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWM76_01255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM76_01265	COG0470	DNA polymerase III
AWM76_01270	COG1396	sequence-specific DNA binding
AWM76_01285	COG3976	FMN-binding domain protein
AWM76_01285	COG0431	NADPH-dependent FMN reductase
AWM76_01285	COG1053	succinate dehydrogenase
AWM76_01295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AWM76_01295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AWM76_01305	COG4467	Involved in initiation control of chromosome replication
AWM76_01310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM76_01315	COG2827	Endonuclease containing a URI domain
AWM76_01320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWM76_01330	COG1970	mechanosensitive ion channel activity
AWM76_01340	COG2801	Transposase and inactivated derivatives
AWM76_01345	COG2079	MmgE PrpD family protein
AWM76_01355	COG0372	Belongs to the citrate synthase family
AWM76_01360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWM76_01370	COG0436	Aminotransferase
AWM76_01375	COG2814	Major facilitator Superfamily
AWM76_01380	COG0656	L-ascorbic acid biosynthetic process
AWM76_01385	COG1078	dGTPase activity
AWM76_01390	COG0095	Lipoate-protein ligase
AWM76_01400	COG3343	RNA polymerase activity
AWM76_01405	COG0504	CTP synthase activity
AWM76_01410	COG0284	orotidine-5'-phosphate decarboxylase activity
AWM76_01420	COG2814	Major facilitator Superfamily
AWM76_01425	COG2832	Protein of unknown function (DUF454)
AWM76_01450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM76_01455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWM76_01460	COG0254	rRNA binding
AWM76_01555	COG0251	oxidation-reduction process
AWM76_01560	COG0456	acetyltransferase
AWM76_01565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM76_01575	COG3764	Sortase (surface protein transpeptidase)
AWM76_01590	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM76_01595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM76_01605	COG0736	holo-[acyl-carrier-protein] synthase activity
AWM76_01615	COG1174	glycine betaine transport
AWM76_01630	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWM76_01635	COG4708	membrane
AWM76_01640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM76_01655	COG1253	flavin adenine dinucleotide binding
AWM76_01725	COG2326	polyphosphate kinase activity
AWM76_01730	COG0288	reversible hydration of carbon dioxide
AWM76_01735	COG4290	ribonuclease
AWM76_01740	COG2732	(Barnase) inhibitor
AWM76_01765	COG0322	excinuclease ABC activity
AWM76_01770	COG1408	metallophosphoesterase
AWM76_01775	COG0513	Belongs to the DEAD box helicase family
AWM76_01785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM76_01795	COG2801	Transposase and inactivated derivatives
AWM76_01805	COG0039	L-malate dehydrogenase activity
AWM76_01810	COG0193	aminoacyl-tRNA hydrolase activity
AWM76_01815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM76_01820	COG2244	polysaccharide biosynthetic process
AWM76_01825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM76_01835	COG1098	S1 RNA binding domain
AWM76_01840	COG0037	tRNA processing
AWM76_01850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM76_01855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM76_01865	COG0640	Transcriptional regulator
AWM76_01870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM76_01875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM76_01880	COG0049	tRNA binding
AWM76_01885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM76_01890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM76_01900	COG0297	glycogen (starch) synthase activity
AWM76_01920	COG0505	Belongs to the CarA family
AWM76_01925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM76_01935	COG1122	ATPase activity
AWM76_01955	COG0051	transcription antitermination factor activity, RNA binding
AWM76_01960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM76_01965	COG0088	Forms part of the polypeptide exit tunnel
AWM76_01970	COG0089	rRNA binding
AWM76_01975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWM76_01985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWM76_01990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWM76_01995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM76_02000	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM76_02005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM76_02010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM76_02015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWM76_02025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM76_02030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWM76_02035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWM76_02040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM76_02045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM76_02050	COG1841	ribosomal large subunit assembly
AWM76_02075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWM76_02080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWM76_02085	COG0202	RNA polymerase activity
AWM76_02090	COG0203	ribosomal protein L17
AWM76_02095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWM76_02095	COG2755	lipolytic protein G-D-S-L family
AWM76_02105	COG1122	ATPase activity
AWM76_02110	COG1122	ATPase activity
AWM76_02130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWM76_02155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM76_02165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWM76_02170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM76_02175	COG0583	DNA-binding transcription factor activity
AWM76_02180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM76_02185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWM76_02195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM76_02200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM76_02205	COG1780	Probably involved in ribonucleotide reductase function
AWM76_02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWM76_02225	COG0662	Cupin 2, conserved barrel domain protein
AWM76_02230	COG1942	4-Oxalocrotonate Tautomerase
AWM76_02310	COG3339	Conserved Protein
AWM76_02325	COG0352	thiamine-phosphate diphosphorylase activity
AWM76_02330	COG0351	phosphomethylpyrimidine kinase
AWM76_02345	COG1473	amidohydrolase
AWM76_02350	COG1473	amidohydrolase
AWM76_02355	COG0601	transmembrane transport
AWM76_02360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM76_02370	COG0444	Belongs to the ABC transporter superfamily
AWM76_02375	COG4608	Belongs to the ABC transporter superfamily
AWM76_02380	COG1131	(ABC) transporter
AWM76_02385	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWM76_02390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWM76_02395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWM76_02400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWM76_02405	COG0131	Imidazoleglycerol-phosphate dehydratase
AWM76_02410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWM76_02415	COG0107	imidazoleglycerol-phosphate synthase activity
AWM76_02420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWM76_02420	COG0140	phosphoribosyl-ATP diphosphatase activity
AWM76_02430	COG2188	Transcriptional regulator
AWM76_02435	COG0386	Belongs to the glutathione peroxidase family
AWM76_02440	COG3328	transposase activity
AWM76_02445	COG0628	permease
AWM76_02465	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM76_02465	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM76_02475	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM76_02505	COG0656	L-ascorbic acid biosynthetic process
AWM76_02565	COG0702	epimerase
AWM76_02570	COG4708	membrane
AWM76_02585	COG2217	Heavy metal translocating P-type atpase
AWM76_02595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM76_02610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_02615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AWM76_02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_02630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_02640	COG4166	transmembrane transport
AWM76_02650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM76_02675	COG2137	regulation of response to DNA damage stimulus
AWM76_02680	COG1194	a g-specific adenine glycosylase
AWM76_02685	COG3557	Belongs to the UPF0374 family
AWM76_02695	COG1523	belongs to the glycosyl hydrolase 13 family
AWM76_02700	COG4129	membrane
AWM76_02705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM76_02715	COG4989	oxidoreductase activity
AWM76_02830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_02835	COG1464	Belongs to the NlpA lipoprotein family
AWM76_02840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AWM76_02865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM76_02870	COG2011	ABC-type metal ion transport system permease component
AWM76_02875	COG1464	Belongs to the NlpA lipoprotein family
AWM76_02880	COG0431	NADPH-dependent FMN reductase
AWM76_02885	COG0454	-acetyltransferase
AWM76_02890	COG0765	amino acid transport
AWM76_02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM76_02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM76_02915	COG1126	abc transporter atp-binding protein
AWM76_02920	COG0686	Belongs to the AlaDH PNT family
AWM76_02925	COG3949	Membrane
AWM76_02935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM76_02945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM76_02950	COG3679	Belongs to the UPF0342 family
AWM76_02955	COG0420	3'-5' exonuclease activity
AWM76_02960	COG4717	serine-type aminopeptidase activity
AWM76_02965	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWM76_02975	COG0737	Belongs to the 5'-nucleotidase family
AWM76_02995	COG0537	adenosine 5'-monophosphoramidase activity
AWM76_03000	COG1131	(ABC) transporter
AWM76_03005	COG4473	ABC transporter
AWM76_03015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWM76_03025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM76_03035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM76_03050	COG1785	Belongs to the alkaline phosphatase family
AWM76_03075	COG1573	uracil-dna glycosylase
AWM76_03095	COG0435	Glutathione S-transferase
AWM76_03105	COG0302	gtp cyclohydrolase
AWM76_03110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWM76_03115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWM76_03125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM76_03135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM76_03145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM76_03145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM76_03150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWM76_03155	COG0237	dephospho-CoA kinase activity
AWM76_03170	COG1484	DNA-dependent DNA replication
AWM76_03185	COG1302	Protein conserved in bacteria
AWM76_03190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM76_03200	COG2818	Glycosylase
AWM76_03205	COG1464	Belongs to the NlpA lipoprotein family
AWM76_03215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWM76_03225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWM76_03230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM76_03235	COG2011	ABC-type metal ion transport system permease component
AWM76_03240	COG1464	Belongs to the NlpA lipoprotein family
AWM76_03260	COG0095	Lipoate-protein ligase
AWM76_03265	COG4862	establishment of competence for transformation
AWM76_03270	COG1393	Belongs to the ArsC family
AWM76_03275	COG0180	Tryptophanyl-tRNA synthetase
AWM76_03300	COG2357	RelA SpoT domain protein
AWM76_03305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWM76_03310	COG0564	pseudouridine synthase activity
AWM76_03315	COG2239	Acts as a magnesium transporter
AWM76_03325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWM76_03330	COG0105	UTP biosynthetic process
AWM76_03335	COG0625	glutathione transferase activity
AWM76_03340	COG2153	protein acetylation
AWM76_03345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM76_03370	COG0542	response to heat
AWM76_03380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM76_03390	COG0438	transferase activity, transferring glycosyl groups
AWM76_03395	COG4703	Protein of unknown function (DUF1797)
AWM76_03400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM76_03405	COG0460	homoserine dehydrogenase
AWM76_03410	COG0083	homoserine kinase activity
AWM76_03415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWM76_03420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM76_03425	COG1534	Rna-binding protein
AWM76_03430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM76_03435	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWM76_03440	COG0799	negative regulation of ribosome biogenesis
AWM76_03445	COG2226	methyltransferase
AWM76_03450	COG1323	Belongs to the UPF0348 family
AWM76_03455	COG1399	metal-binding, possibly nucleic acid-binding protein
AWM76_03460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWM76_03480	COG2001	Belongs to the MraZ family
AWM76_03505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWM76_03510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWM76_03515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM76_03530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM76_03535	COG1799	cell septum assembly
AWM76_03545	COG2302	S4 RNA-binding domain
AWM76_03550	COG3599	regulation of cell shape
AWM76_03555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM76_03570	COG2261	transglycosylase associated protein
AWM76_03575	COG3853	Toxic anion resistance protein (TelA)
AWM76_03600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM76_03605	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM76_03615	COG1104	cysteine desulfurase activity
AWM76_03620	COG0301	tRNA thio-modification
AWM76_03625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWM76_03635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWM76_03640	COG0745	RESPONSE REGULATOR receiver
AWM76_03655	COG0028	Belongs to the TPP enzyme family
AWM76_03660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM76_03665	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_03670	COG0706	membrane insertase activity
AWM76_03675	COG1254	Belongs to the acylphosphatase family
AWM76_03685	COG1280	lysine exporter protein (LysE YggA)
AWM76_03685	COG1674	ftsk spoiiie
AWM76_03690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM76_03705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM76_03750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM76_03760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWM76_03775	COG2255	four-way junction helicase activity
AWM76_03780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM76_03785	COG0587	DNA-directed DNA polymerase activity
AWM76_03790	COG0205	6-phosphofructokinase activity
AWM76_03800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWM76_03810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWM76_03815	COG2996	Protein conserved in bacteria
AWM76_03825	COG4152	abc transporter atp-binding protein
AWM76_03830	COG1668	transmembrane transport
AWM76_03835	COG0456	acetyltransferase
AWM76_03840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM76_03845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM76_03850	COG1187	pseudouridine synthase activity
AWM76_03855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWM76_03865	COG0514	ATP-dependent DNA helicase (RecQ)
AWM76_03875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWM76_03880	COG0539	negative regulation of cytoplasmic translation
AWM76_03885	COG1160	GTP binding
AWM76_03900	COG1621	beta-fructofuranosidase activity
AWM76_03905	COG1609	Transcriptional regulator
AWM76_03920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM76_03925	COG0617	tRNA 3'-terminal CCA addition
AWM76_03930	COG1199	ATP-dependent helicase activity
AWM76_03930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWM76_03950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM76_03955	COG1846	Transcriptional regulator
AWM76_03960	COG0737	Belongs to the 5'-nucleotidase family
AWM76_03965	COG4470	Protein conserved in bacteria
AWM76_03985	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM76_03990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM76_03995	COG1098	S1 RNA binding domain
AWM76_04000	COG0166	Belongs to the GPI family
AWM76_04145	COG1792	Involved in formation and maintenance of cell shape
AWM76_04155	COG0765	amino acid transport
AWM76_04160	COG1126	abc transporter atp-binding protein
AWM76_04170	COG2868	ribosomal protein
AWM76_04185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWM76_04195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AWM76_04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_04200	COG1263	PTS System
AWM76_04205	COG1737	Transcriptional regulator
AWM76_04230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM76_04235	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM76_04235	COG2918	glutathione biosynthetic process
AWM76_04240	COG1104	cysteine desulfurase activity
AWM76_04250	COG0482	sulfurtransferase activity
AWM76_04255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM76_04260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM76_04270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AWM76_04275	COG3906	Belongs to the UPF0473 family
AWM76_04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM76_04290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM76_04305	COG2197	response regulator
AWM76_04315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWM76_04325	COG4129	membrane
AWM76_04330	COG1272	protein, Hemolysin III
AWM76_04345	COG1307	EDD domain protein, DegV family
AWM76_04365	COG4619	ABC transporter
AWM76_04370	COG0390	transport system, permease component
AWM76_04380	COG1072	(Pantothenic acid kinase))
AWM76_04385	COG0628	permease
AWM76_04390	COG1132	(ABC) transporter
AWM76_04400	COG0488	(ABC) transporter
AWM76_04405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM76_04410	COG0248	Ppx GppA phosphatase
AWM76_04415	COG0561	phosphatase activity
AWM76_04420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM76_04425	COG3682	Transcriptional regulator
AWM76_04430	COG1780	Probably involved in ribonucleotide reductase function
AWM76_04435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM76_04445	COG2267	carboxylic ester hydrolase activity
AWM76_04450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM76_04455	COG3331	DNA recombination
AWM76_04460	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWM76_04470	COG1957	nucleoside hydrolase
AWM76_04475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM76_04480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWM76_04485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWM76_04490	COG0358	DNA primase activity
AWM76_04495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM76_04505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM76_04510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWM76_04515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWM76_04520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWM76_04525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWM76_04530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWM76_04535	COG0488	(ABC) transporter
AWM76_04555	COG2384	SAM-dependent methyltransferase
AWM76_04560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM76_04565	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM76_04570	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM76_04575	COG1074	ATP-dependent DNA helicase activity
AWM76_04585	COG0328	RNA-DNA hybrid ribonuclease activity
AWM76_04585	COG3341	Caulimovirus viroplasmin
AWM76_04590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM76_04595	COG0564	pseudouridine synthase activity
AWM76_04600	COG3763	UPF0154 protein
AWM76_04605	COG1132	(ABC) transporter
AWM76_04610	COG1132	(ABC) transporter
AWM76_04615	COG0204	Acyl-transferase
AWM76_04620	COG0628	permease
AWM76_04630	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM76_04635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWM76_04640	COG0528	UMP kinase activity
AWM76_04645	COG0233	cytoplasmic translational termination
AWM76_04650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM76_04655	COG4589	Belongs to the CDS family
AWM76_04660	COG0750	zinc metalloprotease
AWM76_04665	COG2176	DNA-directed DNA polymerase activity
AWM76_04680	COG0779	Required for maturation of 30S ribosomal subunits
AWM76_04685	COG0195	Participates in both transcription termination and antitermination
AWM76_04690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM76_04705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM76_04735	COG3759	membrane
AWM76_04745	COG0740	serine-type endopeptidase activity
AWM76_04750	COG2390	Transcriptional regulator
AWM76_04760	COG0126	phosphoglycerate kinase activity
AWM76_04765	COG0149	triose-phosphate isomerase activity
AWM76_04770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWM76_04775	COG0148	phosphopyruvate hydratase activity
AWM76_04780	COG4166	transmembrane transport
AWM76_04785	COG4166	transmembrane transport
AWM76_04795	COG0601	transmembrane transport
AWM76_04800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM76_04805	COG0444	Belongs to the ABC transporter superfamily
AWM76_04810	COG4608	Belongs to the ABC transporter superfamily
AWM76_04825	COG0557	exoribonuclease II activity
AWM76_04835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM76_04840	COG0588	phosphoglycerate mutase activity
AWM76_04860	COG3328	transposase activity
AWM76_04865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWM76_04870	COG1984	allophanate hydrolase subunit 2
AWM76_04875	COG0511	ligase activity, forming carbon-carbon bonds
AWM76_04880	COG0439	Biotin carboxylase
AWM76_04885	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AWM76_04890	COG1914	H( )-stimulated, divalent metal cation uptake system
AWM76_04900	COG1363	Peptidase, m42
AWM76_04905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWM76_04920	COG2963	transposase activity
AWM76_04940	COG4721	ABC-type cobalt transport system, permease component
AWM76_04945	COG1122	ATPase activity
AWM76_04955	COG3316	Transposase and inactivated derivatives
AWM76_04980	COG2801	Transposase and inactivated derivatives
AWM76_05015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWM76_05025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM76_05035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWM76_05040	COG0439	Biotin carboxylase
AWM76_05045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWM76_05065	COG0116	Belongs to the methyltransferase superfamily
AWM76_05075	COG3599	regulation of cell shape
AWM76_05085	COG2264	protein methyltransferase activity
AWM76_05090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWM76_05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM76_05100	COG1490	D-aminoacyl-tRNA deacylase activity
AWM76_05110	COG0124	histidyl-tRNA synthetase
AWM76_05115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM76_05130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWM76_05140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWM76_05145	COG0167	dihydroorotate dehydrogenase activity
AWM76_05150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM76_05155	COG0346	lactoylglutathione lyase activity
AWM76_05160	COG0735	belongs to the Fur family
AWM76_05170	COG1610	YqeY-like protein
AWM76_05175	COG1028	Short-chain dehydrogenase reductase Sdr
AWM76_05185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWM76_05190	COG1702	phosphate starvation-inducible protein PhoH
AWM76_05195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM76_05205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM76_05210	COG1381	Involved in DNA repair and RecF pathway recombination
AWM76_05215	COG0752	glycyl-tRNA synthetase alpha subunit
AWM76_05220	COG0751	glycine-tRNA ligase activity
AWM76_05230	COG1234	tRNA 3'-trailer cleavage
AWM76_05235	COG4221	oxidoreductase activity
AWM76_05240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM76_05240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM76_05245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM76_05270	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM76_05275	COG1116	anion transmembrane transporter activity
AWM76_05275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM76_05290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM76_05295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM76_05300	COG0494	nUDIX hydrolase
AWM76_05305	COG1349	DNA-binding transcription factor activity
AWM76_05310	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM76_05315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM76_05315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM76_05315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM76_05320	COG1132	(ABC) transporter
AWM76_05325	COG1132	(ABC) transporter
AWM76_05345	COG1653	transport
AWM76_05350	COG3842	ATPase activity
AWM76_05355	COG0366	Alpha amylase catalytic
AWM76_05360	COG1609	Transcriptional regulator
AWM76_05410	COG1301	dicarboxylic acid transport
AWM76_05420	COG4974	Belongs to the 'phage' integrase family
AWM76_05430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM76_05435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM76_05445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM76_05450	COG0569	domain protein
AWM76_05455	COG1227	inorganic diphosphatase activity
AWM76_05480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM76_05485	COG0187	DNA topoisomerase II activity
AWM76_05500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM76_05505	COG0758	DNA mediated transformation
AWM76_05510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWM76_05515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM76_05525	COG3409	Peptidoglycan-binding domain 1 protein
AWM76_05525	COG0793	Belongs to the peptidase S41A family
AWM76_05550	COG0488	(ABC) transporter
AWM76_05595	COG1764	response to oxidative stress
AWM76_05600	COG1846	Transcriptional regulator
AWM76_05605	COG2801	Transposase and inactivated derivatives
AWM76_05615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM76_05620	COG0717	Belongs to the dCTP deaminase family
AWM76_05650	COG2801	Transposase and inactivated derivatives
AWM76_05655	COG0484	heat shock protein binding
AWM76_05665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWM76_05670	COG1420	regulation of RNA biosynthetic process
AWM76_05680	COG0196	riboflavin kinase activity
AWM76_05685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWM76_05690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM76_05695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWM76_05705	COG0009	L-threonylcarbamoyladenylate synthase
AWM76_05710	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM76_05715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWM76_05720	COG1435	thymidine kinase activity
AWM76_05725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM76_05730	COG3442	glutamine amidotransferase
AWM76_05735	COG2135	peptidase activity
AWM76_05745	COG1132	(ABC) transporter
AWM76_05750	COG0628	permease
AWM76_05755	COG2706	6-phosphogluconolactonase activity
AWM76_05760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWM76_05780	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM76_05785	COG2190	(PTS) system
AWM76_05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_05785	COG1263	PTS System
AWM76_05790	COG1968	undecaprenyl-diphosphatase activity
AWM76_05795	COG0527	aspartate kinase activity
AWM76_05800	COG0297	glycogen (starch) synthase activity
AWM76_05805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM76_05810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM76_05825	COG0346	lactoylglutathione lyase activity
AWM76_05845	COG0517	IMP dehydrogenase activity
AWM76_05850	COG0683	leucine binding
AWM76_05855	COG2183	response to ionizing radiation
AWM76_05890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM76_05910	COG0018	arginyl-trna synthetase
AWM76_05920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM76_05930	COG0577	efflux transmembrane transporter activity
AWM76_05930	COG1136	(ABC) transporter
AWM76_05940	COG0509	glycine decarboxylation via glycine cleavage system
AWM76_05945	COG0772	Belongs to the SEDS family
AWM76_05950	COG1295	ribonuclease BN
AWM76_05970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM76_05975	COG0497	DNA recombination
AWM76_05980	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM76_05990	COG1722	exodeoxyribonuclease VII activity
AWM76_05995	COG1570	exodeoxyribonuclease VII activity
AWM76_06000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM76_06005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM76_06015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWM76_06020	COG0006	proline dipeptidase activity
AWM76_06045	COG4537	Required for transformation and DNA binding
AWM76_06050	COG1459	type II secretion system
AWM76_06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM76_06070	COG1269	ATP hydrolysis coupled proton transport
AWM76_06100	COG1394	ATPase activity, coupled to movement of substances
AWM76_06105	COG0217	transcriptional regulatory protein
AWM76_06110	COG1597	lipid kinase activity
AWM76_06115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM76_06120	COG1063	alcohol dehydrogenase
AWM76_06125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM76_06140	COG3830	Belongs to the UPF0237 family
AWM76_06145	COG2843	Capsule synthesis protein
AWM76_06170	COG0668	transmembrane transport
AWM76_06175	COG0622	Phosphoesterase
AWM76_06180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM76_06195	COG3118	belongs to the thioredoxin family
AWM76_06200	COG1193	negative regulation of DNA recombination
AWM76_06250	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWM76_06255	COG1720	tRNA m6t6A37 methyltransferase activity
AWM76_06265	COG2176	DNA-directed DNA polymerase activity
AWM76_06270	COG1671	Belongs to the UPF0178 family
AWM76_06280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM76_06285	COG0765	amino acid transport
AWM76_06290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM76_06300	COG0561	phosphatase activity
AWM76_06315	COG1737	Transcriptional regulator
AWM76_06320	COG0673	inositol 2-dehydrogenase activity
AWM76_06325	COG0673	inositol 2-dehydrogenase activity
AWM76_06330	COG0584	glycerophosphoryl diester phosphodiesterase
AWM76_06335	COG3842	ATPase activity
AWM76_06345	COG1175	transmembrane transport
AWM76_06365	COG1764	response to oxidative stress
AWM76_06370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWM76_06375	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_06430	COG4974	Belongs to the 'phage' integrase family
AWM76_06455	COG1304	FMN binding
AWM76_06470	COG1122	ATPase activity
AWM76_06475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM76_06490	COG0802	atpase or kinase
AWM76_06500	COG0280	phosphate acetyltransferase
AWM76_06505	COG1070	Carbohydrate kinase
AWM76_06510	COG0072	phenylalanine-tRNA ligase activity
AWM76_06515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM76_06520	COG1733	regulation of RNA biosynthetic process
AWM76_06530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM76_06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM76_06540	COG1187	pseudouridine synthase activity
AWM76_06545	COG2244	polysaccharide biosynthetic process
AWM76_06555	COG0495	leucyl-tRNA aminoacylation
AWM76_06560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM76_06570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWM76_06575	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM76_06575	COG1388	LysM domain
AWM76_06580	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM76_06590	COG2801	Transposase and inactivated derivatives
AWM76_06610	COG0628	permease
AWM76_06615	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_06620	COG1278	Cold shock
AWM76_06625	COG2003	Belongs to the UPF0758 family
AWM76_06630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM76_06635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM76_06650	COG0525	valine-tRNA ligase activity
AWM76_06655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM76_06660	COG1940	carbohydrate kinase activity
AWM76_06665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM76_06670	COG0705	Rhomboid family
AWM76_06670	COG0457	Tetratricopeptide repeat
AWM76_06675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM76_06690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWM76_06700	COG0513	Belongs to the DEAD box helicase family
AWM76_06705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWM76_06710	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM76_06715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM76_06720	COG4109	DRTGG domain
AWM76_06740	COG1862	Preprotein translocase
AWM76_06745	COG0343	queuine tRNA-ribosyltransferase activity
AWM76_06760	COG4864	UPF0365 protein
AWM76_06770	COG0542	response to heat
AWM76_06780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM76_06800	COG1937	Protein conserved in bacteria
AWM76_06805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM76_06810	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM76_06825	COG1132	(ABC) transporter
AWM76_06830	COG0151	Belongs to the GarS family
AWM76_06835	COG0138	bifunctional purine biosynthesis protein purh
AWM76_06840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM76_06845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWM76_06850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWM76_06855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM76_06880	COG0673	inositol 2-dehydrogenase activity
AWM76_06885	COG1012	belongs to the aldehyde dehydrogenase family
AWM76_06900	COG0335	large ribosomal subunit rRNA binding
AWM76_06905	COG0469	pyruvate kinase activity
AWM76_06920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWM76_06925	COG1837	Belongs to the UPF0109 family
AWM76_06935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM76_06940	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWM76_06945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM76_06955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM76_06960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AWM76_06965	COG4894	glucomannan catabolic process
AWM76_06970	COG0552	protein localization to endoplasmic reticulum
AWM76_06975	COG0561	phosphatase activity
AWM76_06980	COG1196	nuclear chromosome segregation
AWM76_06985	COG0571	ribonuclease III activity
AWM76_06990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM76_06995	COG0416	fatty acid biosynthetic process
AWM76_07000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM76_07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_07030	COG0708	Exodeoxyribonuclease III
AWM76_07035	COG1012	belongs to the aldehyde dehydrogenase family
AWM76_07035	COG1454	alcohol dehydrogenase
AWM76_07040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWM76_07045	COG1882	Formate acetyltransferase
AWM76_07050	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM76_07140	COG2089	acid synthase
AWM76_07155	COG1028	Short-chain dehydrogenase reductase Sdr
AWM76_07160	COG3980	spore coat polysaccharide biosynthesis protein
AWM76_07165	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AWM76_07170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWM76_07175	COG1086	Polysaccharide biosynthesis protein
AWM76_07200	COG1088	dTDP-glucose 4,6-dehydratase activity
AWM76_07210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AWM76_07250	COG0489	protein tyrosine kinase activity
AWM76_07260	COG3328	transposase activity
AWM76_07300	COG1442	glycosyl transferase family 8
AWM76_07300	COG1216	Glycosyl transferase, family 2
AWM76_07315	COG1215	transferase activity, transferring glycosyl groups
AWM76_07320	COG1215	transferase activity, transferring glycosyl groups
AWM76_07330	COG2801	Transposase and inactivated derivatives
AWM76_07340	COG0438	transferase activity, transferring glycosyl groups
AWM76_07370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWM76_07380	COG2963	transposase activity
AWM76_07395	COG3328	transposase activity
AWM76_07450	COG1302	Protein conserved in bacteria
AWM76_07455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM76_07460	COG1564	THIamine pyrophosphokinase
AWM76_07465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM76_07470	COG1162	GTPase activity
AWM76_07485	COG0515	serine threonine protein kinase
AWM76_07485	COG2815	serine threonine protein kinase
AWM76_07490	COG0631	protein serine/threonine phosphatase activity
AWM76_07495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM76_07495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM76_07500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM76_07505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM76_07510	COG0402	S-adenosylhomocysteine deaminase activity
AWM76_07515	COG1758	RNA polymerase activity
AWM76_07520	COG0194	GDP metabolic process
AWM76_07530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWM76_07545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM76_07550	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM76_07555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWM76_07560	COG0671	phosphoesterase, PA-phosphatase related
AWM76_07565	COG0556	nucleotide-excision repair
AWM76_07580	COG0268	Binds directly to 16S ribosomal RNA
AWM76_07585	COG1466	dna polymerase III delta subunit
AWM76_07590	COG0658	competence protein
AWM76_07590	COG2333	competence protein COMEC
AWM76_07595	COG1555	photosystem II stabilization
AWM76_07595	COG1596	polysaccharide export
AWM76_07605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWM76_07610	COG0742	ribosomal rna small subunit methyltransferase
AWM76_07630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWM76_07635	COG0783	Belongs to the Dps family
AWM76_07700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM76_07720	COG4471	UPF0298 protein
AWM76_07725	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWM76_07730	COG1263	PTS System
AWM76_07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_07730	COG2190	(PTS) system
AWM76_07740	COG0772	Belongs to the SEDS family
AWM76_07750	COG0483	inositol monophosphate 1-phosphatase activity
AWM76_07755	COG4476	Belongs to the UPF0223 family
AWM76_07770	COG0022	dehydrogenase e1 component
AWM76_07780	COG0242	peptide deformylase activity
AWM76_07785	COG2826	transposase and inactivated derivatives, IS30 family
AWM76_07790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWM76_07830	COG3425	synthase
AWM76_07835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AWM76_07840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM76_07850	COG0765	amino acid transport
AWM76_07855	COG0765	amino acid transport
AWM76_07860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM76_07900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWM76_07910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM76_07930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWM76_07950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM76_07955	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM76_07970	COG1876	peptidase activity
AWM76_07975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM76_07980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM76_07985	COG0252	asparaginase activity
AWM76_07990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_08000	COG0489	protein tyrosine kinase activity
AWM76_08015	COG4464	protein tyrosine phosphatase activity
AWM76_08020	COG1051	belongs to the nudix hydrolase family
AWM76_08030	COG1307	EDD domain protein, DegV family
AWM76_08055	COG0516	GMP reductase activity
AWM76_08060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM76_08065	COG1316	TRANSCRIPTIONal
AWM76_08070	COG1316	TRANSCRIPTIONal
AWM76_08075	COG0024	Methionine aminopeptidase
AWM76_08085	COG0716	FMN binding
AWM76_08090	COG2309	aminopeptidase activity
AWM76_08100	COG2246	polysaccharide biosynthetic process
AWM76_08110	COG4485	Bacterial membrane protein, YfhO
AWM76_08130	COG1215	transferase activity, transferring glycosyl groups
AWM76_08145	COG0438	transferase activity, transferring glycosyl groups
AWM76_08145	COG0297	glycogen (starch) synthase activity
AWM76_08155	COG0438	transferase activity, transferring glycosyl groups
AWM76_08165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM76_08170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM76_08175	COG1121	(ABC) transporter
AWM76_08180	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM76_08180	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM76_08185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM76_08190	COG4466	Protein conserved in bacteria
AWM76_08195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM76_08205	COG0084	hydrolase, TatD family'
AWM76_08210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM76_08210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM76_08230	COG2249	NAD(P)H dehydrogenase (quinone) activity
AWM76_08245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AWM76_08270	COG2738	Putative neutral zinc metallopeptidase
AWM76_08290	COG1335	isochorismatase
AWM76_08295	COG0436	Aminotransferase
AWM76_08300	COG1522	sequence-specific DNA binding
AWM76_08320	COG1966	Carbon starvation protein
AWM76_08325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM76_08355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM76_08360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM76_08365	COG0569	domain protein
AWM76_08370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM76_08375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM76_08385	COG4853	Protein conserved in bacteria
AWM76_08395	COG5002	protein histidine kinase activity
AWM76_08400	COG0745	RESPONSE REGULATOR receiver
AWM76_08430	COG1073	alpha beta
AWM76_08435	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM76_08440	COG0628	permease
AWM76_08465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM76_08485	COG0588	phosphoglycerate mutase activity
AWM76_08510	COG3527	Alpha-acetolactate decarboxylase
AWM76_08520	COG0531	amino acid
AWM76_08535	COG2217	Heavy metal translocating P-type atpase
AWM76_08540	COG2217	Heavy metal translocating P-type atpase
AWM76_08545	COG2217	Heavy metal translocating P-type atpase
AWM76_08550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWM76_08580	COG2217	Heavy metal translocating P-type atpase
AWM76_08585	COG3682	Transcriptional regulator
AWM76_08595	COG1307	EDD domain protein, DegV family
AWM76_08605	COG3588	fructose-bisphosphate aldolase
AWM76_08615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWM76_08630	COG2963	transposase activity
AWM76_08635	COG2801	Transposase and inactivated derivatives
AWM76_08645	COG0640	Transcriptional regulator
AWM76_08650	COG2217	Heavy metal translocating P-type atpase
AWM76_08660	COG0745	RESPONSE REGULATOR receiver
AWM76_08665	COG2205	protein histidine kinase activity
AWM76_08680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM76_08730	COG2217	Heavy metal translocating P-type atpase
AWM76_08740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWM76_08765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM76_08770	COG4807	Protein conserved in bacteria
AWM76_08785	COG2963	transposase activity
AWM76_08795	COG2963	transposase activity
AWM76_08800	COG2723	6-phospho-beta-galactosidase activity
AWM76_08805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM76_08805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM76_08810	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWM76_08815	COG3684	Belongs to the aldolase LacD family
AWM76_08825	COG0698	ribose 5-phosphate isomerase
AWM76_08830	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM76_08835	COG1349	DNA-binding transcription factor activity
AWM76_08840	COG0753	catalase activity
AWM76_08845	COG1902	pentaerythritol trinitrate reductase activity
AWM76_08850	COG1733	regulation of RNA biosynthetic process
AWM76_08880	COG1193	negative regulation of DNA recombination
AWM76_08885	COG0564	pseudouridine synthase activity
AWM76_08890	COG4720	Psort location CytoplasmicMembrane, score
AWM76_08910	COG2801	Transposase and inactivated derivatives
AWM76_08920	COG0159	tryptophan synthase activity
AWM76_08925	COG0133	tryptophan synthase activity
AWM76_08945	COG0512	Glutamine amidotransferase of anthranilate synthase
AWM76_08945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWM76_08975	COG0778	Nitroreductase
AWM76_08990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM76_09010	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM76_09025	COG2801	Transposase and inactivated derivatives
AWM76_09030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM76_09035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM76_09060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM76_09065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM76_09070	COG0154	amidase activity
AWM76_09080	COG4851	CamS sex pheromone cAM373 precursor
AWM76_09085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM76_09090	COG0210	DNA helicase
AWM76_09100	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM76_09110	COG0411	ABC transporter
AWM76_09120	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWM76_09160	COG1309	transcriptional regulator
AWM76_09190	COG1960	acyl-CoA dehydrogenase activity
AWM76_09200	COG0583	DNA-binding transcription factor activity
AWM76_09205	COG1024	Enoyl-CoA hydratase
AWM76_09210	COG0183	Belongs to the thiolase family
AWM76_09215	COG1024	Enoyl-CoA hydratase
AWM76_09215	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWM76_09220	COG1960	acyl-CoA dehydrogenase activity
AWM76_09245	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AWM76_09255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM76_09265	COG5002	protein histidine kinase activity
AWM76_09265	COG3850	Histidine kinase
AWM76_09270	COG0745	RESPONSE REGULATOR receiver
AWM76_09275	COG0629	single-stranded DNA binding
AWM76_09285	COG1481	regulation of sporulation
AWM76_09295	COG1660	Displays ATPase and GTPase activities
AWM76_09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM76_09305	COG0492	ferredoxin-NADP+ reductase activity
AWM76_09310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWM76_09315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWM76_09320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM76_09325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWM76_09335	COG1983	PspC domain protein
AWM76_09345	COG0419	ATPase involved in DNA repair
AWM76_09350	COG0420	3'-5' exonuclease activity
AWM76_09355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWM76_09360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM76_09365	COG0581	inorganic phosphate transmembrane transporter activity
AWM76_09370	COG0573	inorganic phosphate transmembrane transporter activity
AWM76_09375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWM76_09380	COG5002	protein histidine kinase activity
AWM76_09385	COG0745	RESPONSE REGULATOR receiver
AWM76_09390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM76_09395	COG0653	protein targeting
AWM76_09410	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM76_09415	COG1307	EDD domain protein, DegV family
AWM76_09420	COG1739	Uncharacterized protein family UPF0029
AWM76_09425	COG0277	FAD linked oxidase domain protein
AWM76_09445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM76_09450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM76_09470	COG0765	amino acid transport
AWM76_09475	COG0431	NADPH-dependent FMN reductase
AWM76_09485	COG0765	amino acid transport
AWM76_09490	COG0165	Argininosuccinate lyase
AWM76_09500	COG0459	protein refolding
AWM76_09505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWM76_09520	COG0488	(ABC) transporter
AWM76_09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM76_09555	COG0494	nUDIX hydrolase
AWM76_09560	COG0513	Belongs to the DEAD box helicase family
AWM76_09580	COG1394	ATPase activity, coupled to movement of substances
AWM76_09585	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AWM76_09590	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM76_09595	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AWM76_09600	COG1527	subunit (C
AWM76_09605	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AWM76_09610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM76_09615	COG1269	ATP hydrolysis coupled proton transport
AWM76_09625	COG0590	tRNA wobble adenosine to inosine editing
AWM76_09630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_09630	COG1263	PTS System
AWM76_09635	COG0366	Alpha amylase catalytic
AWM76_09645	COG2188	Transcriptional regulator
AWM76_09665	COG0542	response to heat
AWM76_09675	COG0473	3-isopropylmalate dehydrogenase activity
AWM76_09680	COG2851	Citrate transporter
AWM76_09685	COG2851	Citrate transporter
AWM76_09730	COG1940	carbohydrate kinase activity
AWM76_09745	COG0058	SHG alpha-glucan phosphorylase activity
AWM76_09750	COG1640	4-alpha-glucanotransferase
AWM76_09755	COG1609	Transcriptional regulator
AWM76_09775	COG0673	inositol 2-dehydrogenase activity
AWM76_09780	COG3842	ATPase activity
AWM76_09790	COG3833	ABC-type maltose transport systems, permease component
AWM76_09795	COG1175	transmembrane transport
AWM76_09800	COG2182	Extracellular solute-binding protein
AWM76_09810	COG2190	(PTS) system
AWM76_09810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_09810	COG1263	PTS System
AWM76_09825	COG1737	Transcriptional regulator
AWM76_09830	COG1486	melibiose metabolic process
AWM76_09835	COG1263	PTS System
AWM76_09835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM76_09840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM76_09870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM76_09875	COG0456	acetyltransferase
AWM76_09880	COG0456	acetyltransferase
AWM76_09885	COG1214	PFAM Peptidase M22, glycoprotease
AWM76_09890	COG2211	Major facilitator Superfamily
AWM76_09895	COG0346	lactoylglutathione lyase activity
AWM76_09900	COG0400	carboxylic ester hydrolase activity
AWM76_09930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AWM76_09940	COG1131	(ABC) transporter
AWM76_09945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWM76_09950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWM76_09955	COG0440	acetolactate synthase activity
AWM76_09960	COG0028	Belongs to the TPP enzyme family
AWM76_09965	COG1119	ATPase activity
AWM76_09975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM76_09995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM76_10005	COG0561	phosphatase activity
AWM76_10010	COG0366	Alpha amylase catalytic
AWM76_10015	COG2252	PERMEase
AWM76_10020	COG1304	FMN binding
AWM76_10025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWM76_10035	COG2226	methyltransferase
AWM76_10045	COG1028	Short-chain dehydrogenase reductase Sdr
AWM76_10055	COG1464	Belongs to the NlpA lipoprotein family
AWM76_10060	COG0436	Aminotransferase
AWM76_10065	COG0246	Mannitol dehydrogenase
AWM76_10070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM76_10075	COG3711	transcriptional antiterminator
AWM76_10080	COG2213	PTS system mannitol-specific
AWM76_10085	COG0363	glucosamine-6-phosphate deaminase activity
AWM76_10090	COG1028	Short-chain dehydrogenase reductase Sdr
AWM76_10100	COG2801	Transposase and inactivated derivatives
AWM76_10110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM76_10115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWM76_10120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM76_10125	COG0151	Belongs to the GarS family
AWM76_10135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM76_10145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWM76_10150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM76_10155	COG0047	phosphoribosylformylglycinamidine synthase activity
AWM76_10160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM76_10175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWM76_10195	COG1187	pseudouridine synthase activity
AWM76_10210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM76_10220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM76_10230	COG1302	Protein conserved in bacteria
AWM76_10250	COG1486	melibiose metabolic process
AWM76_10255	COG1737	Transcriptional regulator