locus-tag class description AERYTH_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AERYTH_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AERYTH_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase AERYTH_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AERYTH_00025 ENOG4105K7N UPF0232 protein AERYTH_00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AERYTH_00045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AERYTH_00070 ENOG410880N Fungalysin/Thermolysin Propeptide Motif AERYTH_00090 ENOG4105CJ1 ABC, transporter AERYTH_00095 ENOG4105KCT ABC transporter AERYTH_00100 ENOG4105BZU Histidine kinase AERYTH_00120 ENOG4105PGM cation diffusion facilitator family transporter AERYTH_00135 ENOG4105EUB pirin domain protein AERYTH_00160 ENOG4105C5X domain protein AERYTH_00195 ENOG4108JQ6 ABC transporter AERYTH_00200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AERYTH_00205 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AERYTH_00220 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AERYTH_00235 ENOG4105E39 Enoyl-CoA hydratase AERYTH_00270 ENOG4105DWV Homoserine O-trans-acetylase AERYTH_00330 ENOG4108RF4 Tetr family transcriptional regulator AERYTH_00355 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_00360 ENOG4107QX3 carboxylase AERYTH_00395 ENOG4105ERH Fumarylacetoacetate hydrolase AERYTH_00425 ENOG4105CSH Transporter AERYTH_00435 ENOG4105GR3 Histidine kinase AERYTH_00445 ENOG4107S4Y M20 DapE family protein YgeY AERYTH_00450 ENOG41086VY Fic/DOC family AERYTH_00480 ENOG4105C0H protease AERYTH_00485 ENOG41062D9 Histidine kinase AERYTH_00490 ENOG4105ETX regulatoR AERYTH_00500 ENOG4105KJF protein tyrosine phosphatase AERYTH_00505 ENOG41082T9 Membrane AERYTH_00515 ENOG4105CIH Imidazole acetol-phosphate transaminase AERYTH_00530 ENOG4105CPP Dehydrogenase, E1 component AERYTH_00535 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AERYTH_00545 ENOG4105XPP Protein of unknown function (DUF1275) AERYTH_00550 ENOG4107SCA Formamidase (EC 3.5.1.49) AERYTH_00555 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AERYTH_00580 ENOG4105C5R Aminotransferase AERYTH_00585 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AERYTH_00600 ENOG4105C7W Xanthine dehydrogenase AERYTH_00610 ENOG4107Y2X deaminase AERYTH_00675 ENOG4105CSU acyl-Coa dehydrogenase AERYTH_00685 ENOG4105JQN Transcriptional regulator AERYTH_00700 ENOG4105NDK ethanolamine utilization protein AERYTH_00720 ENOG4105BZU Histidine kinase AERYTH_00740 ENOG4105CHH sulfate transporter AERYTH_00745 ENOG41085FC arsR family transcriptional regulator AERYTH_00760 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AERYTH_00765 ENOG4105CMR udp-glucose 4-epimerase AERYTH_00800 ENOG4105DHP deoxycytidine triphosphate deaminase AERYTH_00805 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AERYTH_00810 ENOG4105D7K pfkb domain protein AERYTH_00825 ENOG4108W8B Beta-lactamase domain protein AERYTH_00830 ENOG4105DF6 Fe-S oxidoreductase AERYTH_00835 ENOG4105E5T Major Facilitator Superfamily AERYTH_00875 ENOG4108JJB ABC transporter AERYTH_00935 ENOG4105C72 UPF0176 protein AERYTH_00960 ENOG4105CPC Aldo Keto reductase AERYTH_00965 ENOG4105EET magnesium chelatase AERYTH_00970 ENOG4107KWJ von Willebrand factor, type A AERYTH_00980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AERYTH_00990 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_00995 ENOG4105BZU Histidine kinase AERYTH_01005 ENOG4105CFG Acts as a chaperone (By similarity) AERYTH_01010 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AERYTH_01015 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AERYTH_01020 ENOG4105KNI merR family transcriptional Regulator AERYTH_01225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AERYTH_01230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AERYTH_01245 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase AERYTH_01270 ENOG4105D5P Methylmalonyl-coA mutase AERYTH_01290 ENOG4105C6Z Gluconate AERYTH_01310 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AERYTH_01330 ENOG4108JJB ABC transporter AERYTH_01345 ENOG4108N5B 2-phosphosulfolactate phosphatase AERYTH_01415 ENOG4105CC9 acyl-Coa dehydrogenase AERYTH_01445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AERYTH_01465 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AERYTH_01520 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_01525 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AERYTH_01535 ENOG4105FF5 Membrane AERYTH_01540 ENOG4108KXM LysR family Transcriptional regulator AERYTH_01545 ENOG4106T9R serine protease AERYTH_01550 ENOG4105CFH Aspartokinase AERYTH_01575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AERYTH_01590 ENOG4108KK4 3-dehydroquinate synthase AERYTH_01605 ENOG4105CPF Cell wall formation (By similarity) AERYTH_01660 ENOG4105BZ4 penicillin-binding protein AERYTH_01665 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_01705 ENOG4105CI3 gtp-binding protein typa AERYTH_01715 ENOG4105C0R drug resistance transporter emrb qaca subfamily AERYTH_01725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AERYTH_01730 ENOG4108YZJ Pfam:DUF2596 AERYTH_01735 ENOG4108IY8 ABC, transporter AERYTH_01745 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AERYTH_01755 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AERYTH_01785 ENOG4108VJ1 Transcriptional regulator (CarD family AERYTH_01790 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AERYTH_01800 ENOG4105C8N cysteinyl-tRNA synthetase AERYTH_01810 ENOG4105CMR udp-glucose 4-epimerase AERYTH_01815 ENOG4105XPP Protein of unknown function (DUF1275) AERYTH_01825 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AERYTH_01845 ENOG4105FBW Monooxygenase AERYTH_01870 ENOG410633P Hydantoin racemase AERYTH_01900 ENOG4105XTG Pfam:DUF156 AERYTH_01925 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AERYTH_01930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AERYTH_01935 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AERYTH_01945 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AERYTH_01975 ENOG4105EYU Glutamine amido-transferase AERYTH_01980 ENOG4105M90 Glutamate synthase alpha subunit domain protein AERYTH_01985 ENOG4105CBC glutamate synthase AERYTH_02000 ENOG4108JCI Transcriptional regulator AERYTH_02005 ENOG4105CHU acetyl-coa acetyltransferase AERYTH_02010 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_02015 ENOG4108R85 Short chain dehydrogenase AERYTH_02030 ENOG4105C2J ABC transporter AERYTH_02035 ENOG4105CNN ABC, transporter AERYTH_02040 ENOG4108UKI Enoyl-CoA hydratase AERYTH_02050 ENOG4105CHR reductase AERYTH_02070 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AERYTH_02145 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AERYTH_02150 ENOG4108M6P methyltransferase AERYTH_02175 ENOG4108638 50S ribosomal protein L36 AERYTH_02180 ENOG41068HZ 50S ribosomal protein L32 AERYTH_02190 ENOG4105NRA 50s ribosomal protein l31 type b AERYTH_02195 ENOG4105KDC 50s ribosomal protein l28 AERYTH_02200 ENOG4105W0E 50S ribosomal protein L33 AERYTH_02205 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AERYTH_02225 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_02235 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AERYTH_02250 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AERYTH_02300 ENOG4105VEQ Cold shock protein AERYTH_02330 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AERYTH_02340 ENOG4105EQK -acetyltransferase AERYTH_02345 ENOG4105D01 (LipO)protein AERYTH_02350 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AERYTH_02355 ENOG4108UMI ABC transporter, permease AERYTH_02360 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AERYTH_02365 ENOG4107R7A Allophanate hydrolase subunit 2 AERYTH_02370 ENOG4105P4J Allophanate hydrolase, subunit 1 AERYTH_02375 ENOG4105E7W lamb ycsf family protein AERYTH_02385 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AERYTH_02390 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AERYTH_02445 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AERYTH_02460 ENOG4107QVP Dehydrogenase AERYTH_02470 ENOG410650H (LipO)protein AERYTH_02475 ENOG4105DBE peroxidase AERYTH_02480 ENOG4105C26 Dehydrogenase AERYTH_02495 ENOG4105EYW Ion transport protein AERYTH_02505 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AERYTH_02510 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AERYTH_02545 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AERYTH_02550 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AERYTH_02560 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AERYTH_02580 ENOG4107QIK phosphoribosylformylglycinamidine synthase AERYTH_02610 ENOG4105CXB phosphoribosylaminoimidazole synthetase AERYTH_02615 ENOG4105EYF MMPL domain protein AERYTH_02620 ENOG410834F Transcriptional regulator AERYTH_02625 ENOG4107RDP Dehydrogenase AERYTH_02650 ENOG4105CHR reductase AERYTH_02670 ENOG4108IG5 Transcriptional regulator AERYTH_02685 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AERYTH_02705 ENOG4108IJ8 ABC transporter AERYTH_02710 ENOG4105E90 ABC transporter AERYTH_02725 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AERYTH_02730 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AERYTH_02760 ENOG4105JSC dimethylmenaquinone methyltransferase AERYTH_02785 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AERYTH_02790 ENOG4105CGK Exodeoxyribonuclease III AERYTH_02795 ENOG4105KJM monovalent cation h antiporter subunit g AERYTH_02810 ENOG4108JPZ Monovalent cation H antiporter subunit D AERYTH_02815 ENOG4105MKQ Monovalent cation H antiporter subunit C AERYTH_02820 ENOG4105D65 subunit l AERYTH_02830 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AERYTH_02835 ENOG4108UGV hypoxanthine phosphoribosyltransferase AERYTH_02845 ENOG4105EUJ GTP cyclohydrolase i AERYTH_02850 ENOG4105EEI dihydropteroate synthase AERYTH_02865 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AERYTH_02890 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AERYTH_02895 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AERYTH_02900 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AERYTH_02915 ENOG41067RQ csbd family AERYTH_02930 ENOG4105CRK lysyL-tRNA synthetase AERYTH_02945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AERYTH_02950 ENOG4105E98 transcriptional regulator DeoR family AERYTH_02970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AERYTH_03025 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AERYTH_03030 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AERYTH_03040 ENOG4108JWX AERYTH_03045 ENOG4107R33 ppx gppa phosphatase AERYTH_03050 ENOG4105EY0 Xylose isomerase domain protein TIM barrel AERYTH_03060 ENOG4105DHU Bile acid AERYTH_03065 ENOG4105II7 pyrroline-5-carboxylate reductase AERYTH_03070 ENOG4105DGU Histone deacetylase AERYTH_03100 ENOG4108RXW HAD-superfamily subfamily IB hydrolase AERYTH_03105 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_03115 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AERYTH_03120 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AERYTH_03125 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AERYTH_03130 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AERYTH_03135 ENOG4105D52 delta-aminolevulinic acid dehydratase AERYTH_03140 ENOG4105F9F transposase AERYTH_03150 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AERYTH_03155 ENOG4108RH7 phosphoglycerate mutase AERYTH_03165 ENOG4107QIV Cytochrome c biogenesis protein AERYTH_03175 ENOG4105CRE cytochrome C AERYTH_03195 ENOG4105C6T cysteine synthase AERYTH_03225 ENOG4107TCW O-succinylbenzoate synthase AERYTH_03230 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AERYTH_03245 ENOG4105E4F Isochorismate synthase AERYTH_03250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AERYTH_03260 ENOG41082SX arsR family transcriptional regulator AERYTH_03270 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AERYTH_03275 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AERYTH_03280 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AERYTH_03295 ENOG4108IEH NADH dehydrogenase subunit g AERYTH_03300 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AERYTH_03305 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AERYTH_03310 ENOG4105DF2 NADH dehydrogenase subunit j AERYTH_03315 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AERYTH_03320 ENOG4105D65 subunit l AERYTH_03330 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AERYTH_03365 ENOG4108VPT UPF0234 protein AERYTH_03395 ENOG4105C9U ATP-dependent DNA helicase RecQ AERYTH_03405 ENOG4105EW9 transcriptional regulator AsnC family AERYTH_03425 ENOG4105D82 Glutamate dehydrogenase AERYTH_03450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AERYTH_03455 ENOG4107TYH extracellular solute-binding protein family 1 AERYTH_03460 ENOG4105D81 ABC transporter, permease AERYTH_03465 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AERYTH_03470 ENOG4105C26 Dehydrogenase AERYTH_03475 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AERYTH_03490 ENOG4105WDJ 50S ribosomal protein L33 AERYTH_03495 ENOG4107R4N Cell wall formation (By similarity) AERYTH_03530 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AERYTH_03535 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AERYTH_03540 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AERYTH_03545 ENOG4105BZU Histidine kinase AERYTH_03570 ENOG4105BZU Histidine kinase AERYTH_03580 ENOG4108VZM 50s ribosomal protein L10 AERYTH_03585 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AERYTH_03645 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AERYTH_03650 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AERYTH_03660 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AERYTH_03680 ENOG4105CQB FAD linked oxidase domain protein AERYTH_03690 ENOG4107TE5 Lipid kinase AERYTH_03695 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AERYTH_03700 ENOG4105C12 Phosphoribosylglycinamide synthetase AERYTH_03710 ENOG4105C83 adenylosuccinate lyase AERYTH_03715 ENOG4105C8V SAICAR synthetase AERYTH_03720 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_03730 ENOG4105ZXK Dehydrogenase AERYTH_03735 ENOG410839H phosphoribosylformylglycinamidine synthase AERYTH_03740 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AERYTH_03755 ENOG4105C1J atp-dependent rna helicase AERYTH_03780 ENOG4107FQ9 ethanolamine ammonia-lyase AERYTH_03785 ENOG4105CPD ethanolamine ammonia-lyase AERYTH_03790 ENOG4105CUB amino acid AERYTH_03800 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AERYTH_03820 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_03830 ENOG4105EEQ Na H antiporter AERYTH_03835 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AERYTH_03845 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AERYTH_03870 ENOG4105CMV Succinyl-CoA synthetase subunit beta AERYTH_03895 ENOG4105DC1 bifunctional purine biosynthesis protein purh AERYTH_03915 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AERYTH_03930 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AERYTH_03935 ENOG4105CH6 catalase AERYTH_03940 ENOG4105E9K Isocitrate dehydrogenase AERYTH_03945 ENOG4105F27 Major Facilitator AERYTH_03970 ENOG4108I5D sulfate abc transporter AERYTH_03975 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AERYTH_04000 ENOG4105CQC Prephenate dehydratase AERYTH_04005 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AERYTH_04010 ENOG4105C31 Tryptophanyl-tRNA synthetase AERYTH_04030 ENOG4105DND Transcriptional regulator AERYTH_04045 ENOG4105E33 succinate dehydrogenase AERYTH_04065 ENOG4107RM1 amidohydrolase AERYTH_04070 ENOG4105DIH basic membrane AERYTH_04075 ENOG4108JQ9 ABC transporter AERYTH_04080 ENOG4105UIB (ABC) transporter AERYTH_04110 ENOG4105C26 Dehydrogenase AERYTH_04115 ENOG4105C26 Dehydrogenase AERYTH_04120 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AERYTH_04125 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AERYTH_04155 ENOG4108Z4U Ferredoxin AERYTH_04165 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AERYTH_04170 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AERYTH_04175 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AERYTH_04195 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AERYTH_04230 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AERYTH_04240 ENOG4105VEQ Cold shock protein AERYTH_04250 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AERYTH_04260 ENOG41083TI Protein CrcB homolog AERYTH_04265 ENOG4107JBM CrcB-like protein AERYTH_04270 ENOG4105CPC Aldo Keto reductase AERYTH_04290 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AERYTH_04305 ENOG4108YYC ycei family AERYTH_04315 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_04320 ENOG4105CHU acetyl-coa acetyltransferase AERYTH_04325 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AERYTH_04330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AERYTH_04335 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AERYTH_04360 ENOG4105D8K carboxyl transferase AERYTH_04365 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AERYTH_04380 ENOG4105D8X mechanosensitive ion channel AERYTH_04395 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AERYTH_04400 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AERYTH_04415 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AERYTH_04420 ENOG4107QZF nitrite reductase NADPH large subunit AERYTH_04430 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AERYTH_04435 ENOG4105DQQ Major facilitator superfamily MFS_1 AERYTH_04440 ENOG4105MC2 DSBA oxidoreductase AERYTH_04490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AERYTH_04530 ENOG4107U9T Pfam:Ribonuclease_BN AERYTH_04535 ENOG4108V9W transcriptional regulatory protein AERYTH_04540 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AERYTH_04560 ENOG4105SHT UspA domain-containing protein AERYTH_04575 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AERYTH_04625 ENOG4107E6A Cytochrome p-450 AERYTH_04635 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AERYTH_04685 ENOG4105EEF Alkane 1-monooxygenase AERYTH_04690 ENOG41084UD rubredoxin AERYTH_04695 ENOG4105VCQ rubredoxin AERYTH_04725 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AERYTH_04730 ENOG4105F8V Hydrolase, tatD family AERYTH_04735 ENOG4106839 domain protein AERYTH_04740 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AERYTH_04745 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AERYTH_04750 ENOG4105C5H ABC transporter AERYTH_04765 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AERYTH_04780 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AERYTH_04785 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AERYTH_04795 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) AERYTH_04820 ENOG4105BZU Histidine kinase AERYTH_04825 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AERYTH_04830 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AERYTH_04860 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AERYTH_04865 ENOG4105EHG Permease protein AERYTH_04880 ENOG4105JFG SpoIID LytB domain protein AERYTH_04890 ENOG4108JIK carboxylase AERYTH_04895 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_04905 ENOG4107WR6 Maf-like protein AERYTH_04920 ENOG4105D8K carboxyl transferase AERYTH_04925 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AERYTH_04935 ENOG4108QER Adenylate cyclase AERYTH_04940 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AERYTH_04950 ENOG4105DWT malate dehydrogenase (quinone) AERYTH_04980 ENOG4108KGH TRANSCRIPTIONal AERYTH_04995 ENOG4105EY8 ABC transporter AERYTH_05010 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_05040 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AERYTH_05045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AERYTH_05050 ENOG4105BZU Histidine kinase AERYTH_05055 ENOG4105G3P Lipoprotein lpqB AERYTH_05065 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea AERYTH_05070 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_05075 ENOG4105T0Z Conserved Protein AERYTH_05080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AERYTH_05140 ENOG4105CKK Glycosyl transferase, family 2 AERYTH_05145 ENOG4105EDW glycosyl transferase, family 39 AERYTH_05150 ENOG4105BZU Histidine kinase AERYTH_05155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AERYTH_05165 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AERYTH_05230 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AERYTH_05250 ENOG4105K59 histidine triad (HIT) protein AERYTH_05255 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AERYTH_05260 ENOG4105S6R Iron-hydroxamate transporter permease subunit AERYTH_05265 ENOG4105J76 Periplasmic binding protein AERYTH_05270 ENOG4105E0A ABC, transporter AERYTH_05285 ENOG4105CAK Cell division ATP-binding protein ftsE AERYTH_05300 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AERYTH_05315 ENOG4108K8S endonuclease I AERYTH_05350 ENOG4105PDP Short chain dehydrogenase AERYTH_05365 ENOG4105CC5 ABC transporter AERYTH_05370 ENOG4105DIK (ABC) transporter AERYTH_05380 ENOG4105DSE periplasmic solute binding protein AERYTH_05405 ENOG4105KZX Pterin carbinolamine dehydratase AERYTH_05415 ENOG4105CT3 Monooxygenase AERYTH_05435 ENOG4108R5T secreted protein AERYTH_05440 ENOG4108Q5F Tetr family transcriptional regulator AERYTH_05455 ENOG4108UJU UPF0301 protein AERYTH_05480 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_05490 ENOG4105DEN Luciferase family AERYTH_05495 ENOG4108RWI nicotinamidase AERYTH_05505 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AERYTH_05510 ENOG4108Q7D Domain of unknown function (DUF2017) AERYTH_05520 ENOG4107SNB ankyrin repeat protein YahD AERYTH_05525 ENOG4108WYP Transcriptional regulator AERYTH_05545 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AERYTH_05555 ENOG4105DRP amino acid AbC transporter AERYTH_05560 ENOG4105CDA abc transporter atp-binding protein AERYTH_05565 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AERYTH_05570 ENOG4108RQ5 Beta-lactamase domain-containing protein AERYTH_05575 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AERYTH_05580 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AERYTH_05590 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AERYTH_05620 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AERYTH_05645 ENOG4105CI0 Citrate lyase AERYTH_05655 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AERYTH_05675 ENOG4105EMU Dehydrogenase AERYTH_05680 ENOG4107R4C succinyl-diaminopimelate desuccinylase AERYTH_05685 ENOG4108URH decarboxylase AERYTH_05695 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AERYTH_05720 ENOG4105DU6 RNA polymerase AERYTH_05730 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AERYTH_05745 ENOG4105CJW magnesium transporter AERYTH_05755 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AERYTH_05765 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AERYTH_05795 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_05815 ENOG4105DJG MaoC domain protein dehydratase AERYTH_05820 ENOG4108ZM9 phosphoglycerate mutase AERYTH_05825 ENOG4105DB7 PHP domain protein AERYTH_05855 ENOG4108W6C Dehydrogenase AERYTH_05860 ENOG4107QJE Chromosome Partitioning Protein AERYTH_05865 ENOG4105C1J atp-dependent rna helicase AERYTH_05885 ENOG4107Z3H Transcriptional regulator, TetR family AERYTH_05900 ENOG4105C4R Atp-dependent dna helicase AERYTH_05965 ENOG41063PX domain protein AERYTH_05975 ENOG4105DJZ UPF0182 protein AERYTH_06030 ENOG4105EYF MMPL domain protein AERYTH_06095 ENOG4108KQ5 Integrase catalytic subunit AERYTH_06105 ENOG4108PYU two-component system response regulator AERYTH_06130 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_06135 ENOG4105DFH Transport of potassium into the cell (By similarity) AERYTH_06195 ENOG4106032 Glutathionylspermidine synthase AERYTH_06220 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AERYTH_06230 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AERYTH_06240 ENOG4105EYF MMPL domain protein AERYTH_06250 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AERYTH_06255 ENOG4108XHQ (2Fe-2S)-binding domain protein AERYTH_06260 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AERYTH_06290 ENOG4105FFC UPF0187 protein AERYTH_06330 ENOG4105EJ2 Transcriptional regulator AERYTH_06340 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AERYTH_06375 ENOG4105E0Y RtcB Protein AERYTH_06380 ENOG4107QX3 carboxylase AERYTH_06420 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AERYTH_06440 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AERYTH_06460 ENOG4108RAV Conserved protein AERYTH_06465 ENOG4105EMN RNA polymerase sigma factor AERYTH_06485 ENOG4105BZ1 (ABC) transporter AERYTH_06520 ENOG4105CB2 alcohol dehydrogenase AERYTH_06540 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AERYTH_06555 ENOG4105CSV Glutaminase AERYTH_06560 ENOG4108Z9K Osmotically inducible protein AERYTH_06570 ENOG4108M8W Monooxygenase AERYTH_06590 ENOG4108UNF response regulator AERYTH_06595 ENOG4105C75 arginyL-tRNA synthetase AERYTH_06600 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AERYTH_06620 ENOG4108Z4X TRANSCRIPTIONal AERYTH_06630 ENOG4105D6E homoserine dehydrogenase AERYTH_06635 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AERYTH_06640 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AERYTH_06655 ENOG4105VFB Binds the 23S rRNA (By similarity) AERYTH_06660 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AERYTH_06665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AERYTH_06680 ENOG4105ESV Glycosyl transferase, family 4 AERYTH_06690 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) AERYTH_06695 ENOG4106DE0 ATP synthase AERYTH_06700 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AERYTH_06705 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AERYTH_06710 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AERYTH_06715 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AERYTH_06720 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AERYTH_06725 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AERYTH_06740 ENOG4105RFZ Methylmalonyl-coA mutase AERYTH_06770 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) AERYTH_06780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AERYTH_06820 ENOG4105CHU acetyl-coa acetyltransferase AERYTH_06825 ENOG4105DJT lAO AO transport system ATPase AERYTH_06845 ENOG4106A0S AERYTH_06850 ENOG4105M6F mutator MutT protein AERYTH_06855 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AERYTH_06880 ENOG4105BZJ Electron transfer flavoprotein AERYTH_06885 ENOG4105C10 Electron transfer flavoprotein AERYTH_06890 ENOG4105DEF Extracellular solute-binding protein, family 5 AERYTH_06895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AERYTH_06900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AERYTH_06905 ENOG4108JQ6 ABC transporter AERYTH_06915 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AERYTH_06920 ENOG4105C0B DNA polymerase III (alpha subunit) AERYTH_06940 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AERYTH_06945 ENOG4108IYU L-aspartate oxidase AERYTH_06950 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AERYTH_06955 ENOG4107QI6 Cysteine desulfurase AERYTH_06965 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AERYTH_06975 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AERYTH_06980 ENOG4105CSR polyphosphate kinase 2 AERYTH_06985 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AERYTH_06990 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AERYTH_06995 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AERYTH_07005 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AERYTH_07030 ENOG4105C01 Dihydroxy-acid dehydratase AERYTH_07045 ENOG4108ZP8 Acetolactate synthase small subunit AERYTH_07050 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AERYTH_07060 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AERYTH_07070 ENOG4105DWF phosphomethylpyrimidine kinase AERYTH_07075 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AERYTH_07080 ENOG4108VW9 Membrane AERYTH_07090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AERYTH_07095 ENOG4105CM2 brancheD-chain amino acid aminotransferase AERYTH_07105 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AERYTH_07130 ENOG4108KK4 3-dehydroquinate synthase AERYTH_07140 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AERYTH_07185 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AERYTH_07215 ENOG4105FDK ABC transporter AERYTH_07220 ENOG4105DSE periplasmic solute binding protein AERYTH_07225 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AERYTH_07280 ENOG4105C4M (Ubiquinol oxidase) subunit I AERYTH_07285 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AERYTH_07290 ENOG4108JJ9 ABC, transporter AERYTH_07315 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AERYTH_07340 ENOG4105E39 Enoyl-CoA hydratase AERYTH_07345 ENOG4105K5M 30s ribosomal protein S16 AERYTH_07350 ENOG41082KU UPF0109 protein AERYTH_07355 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AERYTH_07360 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AERYTH_07370 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AERYTH_07380 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AERYTH_07395 ENOG41080R2 UPF0102 protein AERYTH_07400 ENOG4105C0P Mg chelatase subunit ChlI AERYTH_07410 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AERYTH_07455 ENOG4105E4C Lytic transglycosylase catalytic AERYTH_07460 ENOG4105CE9 30S ribosomal protein S2 AERYTH_07465 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AERYTH_07470 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AERYTH_07475 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AERYTH_07480 ENOG4105KNE Phosphatidate cytidylyltransferase AERYTH_07490 ENOG4105NPQ Pfam:DUF403 AERYTH_07505 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AERYTH_07510 ENOG4105DQF Hydrolase AERYTH_07535 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_07540 ENOG4108ZGX Histidine kinase AERYTH_07545 ENOG4105CJ1 ABC, transporter AERYTH_07560 ENOG4105DZP Membrane-associated zinc metalloprotease AERYTH_07565 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AERYTH_07585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AERYTH_07610 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AERYTH_07615 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AERYTH_07620 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AERYTH_07625 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AERYTH_07635 ENOG4108762 serine threonine protein kinase AERYTH_07645 ENOG41062D9 Histidine kinase AERYTH_07660 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AERYTH_07665 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AERYTH_07675 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AERYTH_07710 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AERYTH_07735 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AERYTH_07740 ENOG4105CN5 Metallo-Beta-Lactamase AERYTH_07750 ENOG4107QZI cell division protein FtsK AERYTH_07765 ENOG4105CEV competence damage-inducible protein AERYTH_07790 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AERYTH_07795 ENOG4105KC9 Modulates RecA activity (By similarity) AERYTH_07810 ENOG4105DRP amino acid AbC transporter AERYTH_07815 ENOG4108Q1T ABC transporter AERYTH_07825 ENOG4105CDA abc transporter atp-binding protein AERYTH_07850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AERYTH_07865 ENOG4105EYF MMPL domain protein AERYTH_07895 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AERYTH_07900 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AERYTH_07905 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AERYTH_07915 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AERYTH_07935 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AERYTH_07940 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AERYTH_07950 ENOG4105X3H Excalibur domain protein AERYTH_07995 ENOG4107QKA exodeoxyribonuclease V beta AERYTH_08000 ENOG4105C7H Helicase, RecD TraA family AERYTH_08020 ENOG4108ZHJ Organic hydroperoxide resistance protein AERYTH_08035 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) AERYTH_08050 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase AERYTH_08055 ENOG4105C26 Dehydrogenase AERYTH_08065 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AERYTH_08075 ENOG4105C6Z Gluconate AERYTH_08080 ENOG4105C0D helicase AERYTH_08085 ENOG41067V3 Antibiotic biosynthesis monooxygenase AERYTH_08090 ENOG41080RH Thioredoxin AERYTH_08105 ENOG4105VEQ Cold shock protein AERYTH_08115 ENOG4107G87 m6 family metalloprotease domain protein AERYTH_08120 ENOG4105DXB Major Facilitator superfamily AERYTH_08135 ENOG4105CGK Exodeoxyribonuclease III AERYTH_08145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AERYTH_08195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AERYTH_08210 ENOG4107UWP Major facilitator superfamily MFS_1 AERYTH_08220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AERYTH_08230 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AERYTH_08240 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AERYTH_08245 ENOG4107W53 thymidine kinase AERYTH_08255 ENOG4105EN6 Membrane AERYTH_08260 ENOG4105C26 Dehydrogenase AERYTH_08270 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AERYTH_08295 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AERYTH_08320 ENOG4107VEG TrkA-N domain protein AERYTH_08325 ENOG4105C0X amino acid AERYTH_08330 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AERYTH_08350 ENOG4107QM5 aconitate hydratase AERYTH_08360 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AERYTH_08375 ENOG4105DJV ribulose-phosphate 3-epimerase AERYTH_08380 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AERYTH_08390 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AERYTH_08395 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AERYTH_08400 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase AERYTH_08405 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AERYTH_08425 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AERYTH_08435 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AERYTH_08440 ENOG4108RWN rrna methyltransferase AERYTH_08450 ENOG4105BZU Histidine kinase AERYTH_08455 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AERYTH_08460 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AERYTH_08465 ENOG4105CDH Citrulline--aspartate ligase AERYTH_08475 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AERYTH_08480 ENOG4105CAS nag kinase AERYTH_08490 ENOG4105DBV ornithine carbamoyltransferase AERYTH_08495 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AERYTH_08500 ENOG4105CH7 arginosuccinase AERYTH_08510 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_08525 ENOG4105K56 Transcriptional regulator AERYTH_08535 ENOG4108URH decarboxylase AERYTH_08540 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AERYTH_08565 ENOG4105C8Y Acetylornithine aminotransferase AERYTH_08585 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein AERYTH_08615 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AERYTH_08620 ENOG4108UW8 fha domain-containing protein AERYTH_08640 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AERYTH_08680 ENOG4105K6V RNA polymerase AERYTH_08700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AERYTH_08725 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AERYTH_08740 ENOG4107RTD sua5 ycio yrdc ywlc family protein AERYTH_08765 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AERYTH_08770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AERYTH_08790 ENOG4105F7P transcriptional regulator AsnC family AERYTH_08815 ENOG4108RNG Permease of the drug metabolite transporter AERYTH_08820 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AERYTH_08830 ENOG4106UW1 Major Facilitator superfamily AERYTH_08840 ENOG4105EV9 Alpha Beta Hydrolase AERYTH_08850 ENOG4105E8R UPF0173 metal-dependent hydrolase AERYTH_08860 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AERYTH_08875 ENOG4105Q70 AERYTH_08880 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AERYTH_08900 ENOG4105HFS 5'-3' exonuclease AERYTH_08915 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AERYTH_08940 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) AERYTH_08945 ENOG4105CPC Aldo Keto reductase AERYTH_08955 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AERYTH_08960 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AERYTH_08965 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) AERYTH_08970 ENOG4105E5F proteasome AERYTH_08985 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AERYTH_09000 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AERYTH_09010 ENOG4105C3R Methionine synthase AERYTH_09025 ENOG4105C8N cysteinyl-tRNA synthetase AERYTH_09040 ENOG4105D7N magnesium and cobalt transport protein CorA AERYTH_09075 ENOG4107QUT magnesium and cobalt transport protein CorA AERYTH_09085 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AERYTH_09090 ENOG4105CPC Aldo Keto reductase AERYTH_09100 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AERYTH_09130 ENOG4107PBV potassium channel AERYTH_09140 ENOG4106BRA Membrane AERYTH_09155 ENOG4105CQ7 ATP-dependent helicase AERYTH_09160 ENOG41081K0 peptidylprolyl cis-trans isomerase AERYTH_09175 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_09185 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AERYTH_09200 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AERYTH_09235 ENOG4108V1U phospholipid-binding protein AERYTH_09250 ENOG4105DKW ABC transporter AERYTH_09255 ENOG4105EAC phosphoserine phosphatase AERYTH_09260 ENOG4105WKW Pfam:DUF1458 AERYTH_09275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AERYTH_09290 ENOG4105C5H ABC transporter AERYTH_09295 ENOG4105VG1 fes assembly suf system protein AERYTH_09300 ENOG4108UNV SUF system FeS assembly protein, NifU family AERYTH_09305 ENOG4105C9B Cysteine desulfurase AERYTH_09310 ENOG4105C3K feS assembly ATPase SufC AERYTH_09355 ENOG4105CJ1 ABC, transporter AERYTH_09365 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AERYTH_09375 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AERYTH_09385 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AERYTH_09390 ENOG4105C89 phosphohexose isomerase AERYTH_09405 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) AERYTH_09420 ENOG4105CP7 Triose-phosphate isomerase AERYTH_09425 ENOG4105BZA Phosphoglycerate kinase AERYTH_09430 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AERYTH_09435 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AERYTH_09440 ENOG4105CIE May be required for sporulation (By similarity) AERYTH_09445 ENOG4105CHW UPF0052 protein AERYTH_09450 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AERYTH_09455 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AERYTH_09465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AERYTH_09490 ENOG4107RY6 amino acid AERYTH_09515 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AERYTH_09525 ENOG4105CHU acetyl-coa acetyltransferase AERYTH_09530 ENOG4105CHR reductase AERYTH_09545 ENOG4105C29 acyl-CoA thioesterase AERYTH_09555 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AERYTH_09565 ENOG4105DGI Alkaline phosphatase AERYTH_09590 ENOG4108HWW ABC transporter AERYTH_09595 ENOG4105C2J ABC transporter AERYTH_09600 ENOG4105DFW ABC transporter AERYTH_09605 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AERYTH_09615 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AERYTH_09620 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AERYTH_09635 ENOG4105SKN orotidine 5''-phosphate decarboxylase AERYTH_09640 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AERYTH_09645 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AERYTH_09650 ENOG4105CD3 dihydroorotase AERYTH_09655 ENOG4105CXT aspartate transcarbamylase AERYTH_09660 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AERYTH_09680 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AERYTH_09685 ENOG4105E90 ABC transporter AERYTH_09690 ENOG4108IJ8 ABC transporter AERYTH_09695 ENOG4105E90 ABC transporter AERYTH_09700 ENOG410803B Involved in the transcription termination process (By similarity) AERYTH_09705 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AERYTH_09715 ENOG4105D49 3-dehydroquinate synthase AERYTH_09720 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AERYTH_09725 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AERYTH_09730 ENOG4105KPY Small multidrug resistance protein AERYTH_09740 ENOG4105E2X shikimate dehydrogenase AERYTH_09745 ENOG4105HHA aminodeoxychorismate lyase AERYTH_09750 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AERYTH_09755 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AERYTH_09785 ENOG4105C9M aspartyl-trna synthetase AERYTH_09790 ENOG4105CUT histidyl-tRNA synthetase AERYTH_09800 ENOG4105C99 atpase involved in dna repair AERYTH_09820 ENOG4107QZ7 Cellulose synthase catalytic subunit AERYTH_09825 ENOG4105WN5 stage II sporulation protein AERYTH_09840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AERYTH_09845 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AERYTH_09855 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AERYTH_09860 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AERYTH_09870 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AERYTH_09875 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AERYTH_09880 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AERYTH_09885 ENOG4105CDY transcriptional regulatory protein AERYTH_09890 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AERYTH_09895 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AERYTH_09905 ENOG4105URP P-aminobenzoate N-oxygenase AurF AERYTH_09910 ENOG4108VTU Cdp-alcohol phosphatidyltransferase AERYTH_09925 ENOG4105C22 threonyL-tRNA synthetase AERYTH_09940 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AERYTH_09960 ENOG4105F95 Monooxygenase AERYTH_09975 ENOG4108UIN ybak prolyl-trna synthetase associated region AERYTH_09985 ENOG4107Z5F Aminotransferase class IV AERYTH_10065 ENOG4108KK1 membrane protein AbrB duplication AERYTH_10070 ENOG4105CSR polyphosphate kinase 2 AERYTH_10075 ENOG4105WCJ ec 1.1.1.193 AERYTH_10085 ENOG4105E0X reductase AERYTH_10090 ENOG4107JTW chlorite dismutase AERYTH_10095 ENOG4105C1Q protoporphyrinogen oxidase AERYTH_10100 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AERYTH_10125 ENOG4105CPC Aldo Keto reductase AERYTH_10170 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AERYTH_10180 ENOG4105P52 geranylgeranyl reductase AERYTH_10195 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AERYTH_10215 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AERYTH_10220 ENOG4105DFM M18 family aminopeptidase AERYTH_10245 ENOG4108M6P methyltransferase AERYTH_10250 ENOG4108I69 Glycosyl transferases group 1 AERYTH_10275 ENOG4108UQV Membrane AERYTH_10280 ENOG4105C32 Amino acid ABC transporter (Permease) AERYTH_10290 ENOG4105C0Z ABC transporter AERYTH_10295 ENOG4108IV0 ABC, transporter AERYTH_10300 ENOG4105CP9 extracellular ligand-binding receptor AERYTH_10320 ENOG4105CA9 Pyruvate kinase AERYTH_10330 ENOG4105CBC glutamate synthase AERYTH_10340 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AERYTH_10345 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AERYTH_10350 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AERYTH_10355 ENOG4105DK0 Indole-3-glycerol phosphate synthase AERYTH_10395 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AERYTH_10400 ENOG4105BZ1 (ABC) transporter AERYTH_10405 ENOG4105BZ1 (ABC) transporter AERYTH_10410 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AERYTH_10425 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AERYTH_10430 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AERYTH_10435 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AERYTH_10445 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AERYTH_10450 ENOG4105DKK Benzoate AERYTH_10455 ENOG4108Z66 YbaK ebsC protein AERYTH_10465 ENOG4105C0B DNA polymerase III (alpha subunit) AERYTH_10500 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AERYTH_10510 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AERYTH_10525 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AERYTH_10530 ENOG4105DFA alanine racemase domain protein AERYTH_10535 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AERYTH_10540 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AERYTH_10545 ENOG4105ME9 cell division protein FtsQ AERYTH_10550 ENOG4105DFU Cell wall formation (By similarity) AERYTH_10555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AERYTH_10565 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AERYTH_10570 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AERYTH_10580 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AERYTH_10585 ENOG4105CJN penicillin-binding protein AERYTH_10595 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AERYTH_10600 ENOG4108V6E Cell division protein mraZ AERYTH_10635 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AERYTH_10660 ENOG4105DKQ ROK family AERYTH_10665 ENOG4105DKQ ROK family AERYTH_10680 ENOG4108IQE Amp-dependent synthetase and ligase AERYTH_10710 ENOG4107S1N anthranilate phosphoribosyltransferase AERYTH_10720 ENOG4105CCU oxidase (Subunit III) AERYTH_10730 ENOG4107EUI c reductase, iron-sulfur AERYTH_10735 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AERYTH_10745 ENOG4105MCD Part of cytochrome c oxidase, its function is AERYTH_10750 ENOG4105BZ9 Cytochrome C oxidase, subunit I AERYTH_10755 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AERYTH_10775 ENOG4105XT2 Transcriptional regulator AERYTH_10785 ENOG4105D0M Protease HtpX homolog AERYTH_10805 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AERYTH_10810 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AERYTH_10850 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AERYTH_10860 ENOG4108IUX (ABC) transporter AERYTH_10865 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_10870 ENOG4105BZU Histidine kinase AERYTH_10875 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AERYTH_10895 ENOG4105C5F glutamine synthetase AERYTH_10950 ENOG4105D8V Glucose sorbosone dehydrogenase AERYTH_10965 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AERYTH_10980 ENOG4105CPQ Dehydrogenase AERYTH_11010 ENOG4105F9F transposase AERYTH_11015 ENOG4105EJ2 Transcriptional regulator AERYTH_11045 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AERYTH_11050 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_11060 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AERYTH_11070 ENOG4105K5B UPF0225 protein AERYTH_11075 ENOG4105C4K Nad synthetase AERYTH_11080 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AERYTH_11115 ENOG4107XFJ UPF0246 protein AERYTH_11120 ENOG4105CVJ phosphoglycerate mutase AERYTH_11130 ENOG4105EGD dinuclear metal center protein, YbgI family AERYTH_11135 ENOG4105C9U ATP-dependent DNA helicase RecQ AERYTH_11165 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AERYTH_11225 ENOG4107W19 lmbE family AERYTH_11255 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AERYTH_11265 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AERYTH_11270 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AERYTH_11275 ENOG41084BZ 50S ribosomal protein L32 AERYTH_11285 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AERYTH_11290 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AERYTH_11295 ENOG4106H78 methyltransferase AERYTH_11305 ENOG4105DP4 dak2 domain fusion protein ylov AERYTH_11310 ENOG4105VB9 50S ribosomal protein l28 AERYTH_11315 ENOG4105DV0 amidase (EC 3.5.1.4 AERYTH_11335 ENOG4105CPF Cell wall formation (By similarity) AERYTH_11340 ENOG4105C28 cystathionine AERYTH_11345 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AERYTH_11360 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AERYTH_11365 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AERYTH_11370 ENOG41069M3 Transcriptional regulator AERYTH_11400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AERYTH_11430 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AERYTH_11435 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AERYTH_11440 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) AERYTH_11450 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AERYTH_11455 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AERYTH_11465 ENOG4108TCJ secreted hydrolase AERYTH_11480 ENOG4105C26 Dehydrogenase AERYTH_11490 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AERYTH_11495 ENOG4105CHF Glutathione S-transferase AERYTH_11500 ENOG4107258 Transcriptional regulator AERYTH_11525 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AERYTH_11530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AERYTH_11550 ENOG4105DCG PHP domain protein AERYTH_11555 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AERYTH_11560 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AERYTH_11575 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AERYTH_11585 ENOG4107YU2 histidine triad (hIT) protein AERYTH_11590 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AERYTH_11595 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AERYTH_11620 ENOG4108IQE Amp-dependent synthetase and ligase AERYTH_11630 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AERYTH_11640 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AERYTH_11655 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AERYTH_11660 ENOG4105KQC Competence protein AERYTH_11670 ENOG41067V3 Antibiotic biosynthesis monooxygenase AERYTH_11675 ENOG4105EPR degv family AERYTH_11680 ENOG4105C8T Leucyl-tRNA synthetase AERYTH_11700 ENOG4107ZYR domain protein AERYTH_11705 ENOG4105CZN Potassium uptake protein AERYTH_11710 ENOG4108MKI Glycosyl transferase, family 2 AERYTH_11715 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AERYTH_11720 ENOG410602S Transferase AERYTH_11735 ENOG4107T8Q Glycosyl transferase (Group 1 AERYTH_11755 ENOG4105EY8 ABC transporter AERYTH_11775 ENOG4105D2T synthase AERYTH_11780 ENOG4105F0R Cytidylyltransferase AERYTH_11795 ENOG4105C9K Endothelin-converting enzyme 1 AERYTH_11800 ENOG4108HH4 Major Facilitator Superfamily AERYTH_11830 ENOG4105I4A GCN5-related N-acetyltransferase AERYTH_11840 ENOG4105C0R drug resistance transporter emrb qaca subfamily AERYTH_11910 ENOG4105E0A ABC, transporter AERYTH_11915 ENOG4105TVJ transport system, permease AERYTH_11920 ENOG4105DQ5 transport system permease protein AERYTH_11955 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AERYTH_11960 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AERYTH_11965 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AERYTH_11975 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AERYTH_11985 ENOG4105K46 50S ribosomal protein l27 AERYTH_11990 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AERYTH_12005 ENOG4105DJ2 Major Facilitator Superfamily AERYTH_12030 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AERYTH_12035 ENOG4105CG3 alpha amylase, catalytic region AERYTH_12075 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AERYTH_12110 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AERYTH_12115 ENOG4105EG6 Saccharopine dehydrogenase AERYTH_12120 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AERYTH_12125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AERYTH_12130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AERYTH_12155 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AERYTH_12165 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AERYTH_12175 ENOG4105C2J ABC transporter AERYTH_12180 ENOG41062B0 ABC transporter, permease AERYTH_12190 ENOG4105C26 Dehydrogenase AERYTH_12195 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AERYTH_12200 ENOG4105DH8 myo-inositol catabolism AERYTH_12210 ENOG4105D7K pfkb domain protein AERYTH_12215 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AERYTH_12220 ENOG4105FDP GntR family transcriptional regulator AERYTH_12240 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AERYTH_12250 ENOG4105DEN Luciferase family AERYTH_12270 ENOG4105C34 Pseudouridine synthase AERYTH_12275 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AERYTH_12285 ENOG4105CAT Cytidine monophosphate kinase AERYTH_12300 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AERYTH_12305 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AERYTH_12325 ENOG4108YZ4 nudix hydrolase AERYTH_12330 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AERYTH_12345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AERYTH_12350 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AERYTH_12365 ENOG4105DSU hydrolase AERYTH_12405 ENOG41068WN AERYTH_12410 ENOG4108RIR Molybdenum cofactor biosynthesis protein AERYTH_12415 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AERYTH_12430 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase AERYTH_12450 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AERYTH_12490 ENOG4107R9S Malate synthase AERYTH_12535 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AERYTH_12545 ENOG4105CGD Nad-dependent epimerase dehydratase AERYTH_12555 ENOG4105CVP deoxyribo-dipyrimidine photolyase AERYTH_12575 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AERYTH_12600 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain AERYTH_12615 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AERYTH_12665 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AERYTH_12695 ENOG4105C3G gtp-binding protein AERYTH_12725 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AERYTH_12740 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AERYTH_12745 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AERYTH_12750 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AERYTH_12790 ENOG4105RHY Pfam:UPF0157 AERYTH_12810 ENOG4107GFK fumarate AERYTH_12815 ENOG4105C9Q fumarate hydratase class II AERYTH_12840 ENOG4108IAB Phoh family AERYTH_12845 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AERYTH_12860 ENOG4105C7Z Conserved Protein AERYTH_12875 ENOG4105T1M mycothiol conjugate amidase mca AERYTH_12885 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AERYTH_12895 ENOG4105C7B Threonine dehydratase AERYTH_12905 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AERYTH_12925 ENOG4105C0R drug resistance transporter emrb qaca subfamily AERYTH_12930 ENOG4108VCA G U mismatch-specific DNA glycosylase AERYTH_12970 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AERYTH_12985 ENOG4105C2W permease AERYTH_13000 ENOG4105ERH Fumarylacetoacetate hydrolase AERYTH_13015 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AERYTH_13045 ENOG4105CQ7 ATP-dependent helicase AERYTH_13060 ENOG4105FDK ABC transporter AERYTH_13070 ENOG4108UVJ appr-1-p processing domain protein AERYTH_13090 ENOG4107QUV Domain protein AERYTH_13150 ENOG4107QJT sodium dicarboxylate symporter AERYTH_13155 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AERYTH_13160 ENOG4108MRH transcriptional regulatory protein AERYTH_13175 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AERYTH_13220 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AERYTH_13225 ENOG4108Z0R Transferase AERYTH_13230 ENOG4105C7N Xanthine uracil vitamin C permease AERYTH_13250 ENOG4108N0W Major Facilitator superfamily AERYTH_13255 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AERYTH_13260 ENOG4105VEQ Cold shock protein AERYTH_13265 ENOG4107U9T Pfam:Ribonuclease_BN AERYTH_13285 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AERYTH_13350 ENOG4105C26 Dehydrogenase AERYTH_13355 ENOG4107RR1 TRANSCRIPTIONal AERYTH_13365 ENOG4105CJ1 ABC, transporter AERYTH_13370 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AERYTH_13390 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AERYTH_13400 ENOG4105F9F transposase AERYTH_13405 ENOG4108097 ATP-binding protein AERYTH_13415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AERYTH_13425 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AERYTH_13430 ENOG4105CS9 pantothenic acid kinase AERYTH_13440 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AERYTH_13445 ENOG4108UJD 30S ribosomal protein S9 AERYTH_13450 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AERYTH_13455 ENOG4105BZN citrate synthase AERYTH_13475 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AERYTH_13485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AERYTH_13495 ENOG4108ZT0 50S ribosomal protein l17 AERYTH_13500 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AERYTH_13505 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AERYTH_13510 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AERYTH_13515 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AERYTH_13520 ENOG41067V7 50S ribosomal protein L36 AERYTH_13525 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AERYTH_13530 ENOG4105EW9 transcriptional regulator AsnC family AERYTH_13535 ENOG4105CIK Amidinotransferase AERYTH_13555 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AERYTH_13565 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AERYTH_13570 ENOG410849U 50S ribosomal protein L30 AERYTH_13575 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AERYTH_13580 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AERYTH_13585 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AERYTH_13590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AERYTH_13595 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AERYTH_13600 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AERYTH_13605 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AERYTH_13610 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AERYTH_13615 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AERYTH_13620 ENOG41082SA 50s ribosomal protein l29 AERYTH_13625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AERYTH_13630 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AERYTH_13635 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AERYTH_13640 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AERYTH_13645 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AERYTH_13650 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AERYTH_13655 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AERYTH_13660 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AERYTH_13665 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AERYTH_13675 ENOG4108KTG Membrane protein, drug metabolite transporter AERYTH_13680 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AERYTH_13685 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AERYTH_13690 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AERYTH_13700 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AERYTH_13705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AERYTH_13710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AERYTH_13715 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AERYTH_13725 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AERYTH_13745 ENOG4108U4N (sortase) family AERYTH_13770 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AERYTH_13790 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AERYTH_13830 ENOG4105VBF alkaline shock protein AERYTH_13835 ENOG4105EMN RNA polymerase sigma factor AERYTH_13855 ENOG4105RJZ Transcriptional regulator AERYTH_13860 ENOG4105C57 major facilitator superfamily AERYTH_13890 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AERYTH_13905 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AERYTH_13915 ENOG4105FA2 dna polymerase iii AERYTH_13925 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AERYTH_13930 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AERYTH_13935 ENOG4105WN5 stage II sporulation protein AERYTH_13940 ENOG4108I5C dEAD DEAH box helicase AERYTH_14005 ENOG4108IAJ Nad-dependent epimerase dehydratase AERYTH_14020 ENOG4108HRK Histidine kinase AERYTH_14030 ENOG4105C0K Gdp-mannose 4,6-dehydratase AERYTH_14035 ENOG4105C30 Nad-dependent epimerase dehydratase AERYTH_14085 ENOG4108UW5 maltose o-acetyltransferase AERYTH_14100 ENOG4107ZYJ bioY protein AERYTH_14105 ENOG4108JJB ABC transporter AERYTH_14115 ENOG4108NEV two component transcriptional regulator, LytTR family AERYTH_14135 ENOG4107QN1 sodium solute AERYTH_14140 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AERYTH_14155 ENOG4105C0H protease AERYTH_14160 ENOG4105P8F nudix hydrolase AERYTH_14165 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AERYTH_14190 ENOG4105C94 Transporter AERYTH_14215 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AERYTH_14225 ENOG4105EIP mannose-6-phosphate isomerase AERYTH_14235 ENOG4107YJ4 chain length determinant protein AERYTH_14245 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AERYTH_14250 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands AERYTH_14255 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AERYTH_14275 ENOG4105PKJ carbohydrate binding AERYTH_14280 ENOG4105KHC sulfurtransferase AERYTH_14290 ENOG4105PY6 Phenolic acid decarboxylase AERYTH_14310 ENOG4107NHD transcriptional regulator AERYTH_14320 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AERYTH_14330 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AERYTH_14345 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AERYTH_14360 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AERYTH_14365 ENOG4105CJ3 phosphate transporter AERYTH_14415 ENOG4105FBW Monooxygenase AERYTH_14420 ENOG4107UWC ABC, transporter AERYTH_14425 ENOG4105E2Y ABC, transporter AERYTH_14430 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AERYTH_14445 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_14450 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AERYTH_14460 ENOG4105H3G oxidoreductase AERYTH_14505 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AERYTH_14515 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AERYTH_14565 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AERYTH_14575 ENOG4105DQ4 alcohol dehydrogenase AERYTH_14580 ENOG4107XC4 flavin reductase domain protein, FMN-binding AERYTH_14585 ENOG4105CPQ Dehydrogenase AERYTH_14600 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AERYTH_14615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AERYTH_14620 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AERYTH_14625 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AERYTH_14635 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase AERYTH_14660 ENOG41081F0 Precorrin-8x methylmutase AERYTH_14675 ENOG4105EHG Permease protein AERYTH_14690 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AERYTH_14705 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AERYTH_14710 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AERYTH_14730 ENOG4105CTK cobaltochelatase, cobn subunit AERYTH_14745 ENOG4105C57 major facilitator superfamily AERYTH_14765 ENOG4105ECR NmrA family AERYTH_14770 ENOG4105DR5 peptidase AERYTH_14800 ENOG4108UKI Enoyl-CoA hydratase AERYTH_14810 ENOG4105C1G acyl-Coa dehydrogenase AERYTH_14830 ENOG4105D74 hydrolase AERYTH_14845 ENOG4105EZE Cupin 4 family protein AERYTH_14870 ENOG4105F0N pyrophosphate phospho-hydrolase AERYTH_14880 ENOG4107RN6 Monooxygenase AERYTH_14950 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AERYTH_14955 ENOG4105DY8 decarboxylase AERYTH_14965 ENOG4105EC2 ftsk spoIIIe AERYTH_15035 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AERYTH_15040 ENOG4108YZT Adenosylcobinamide kinase AERYTH_15050 ENOG4105D22 carbon starvation protein AERYTH_15060 ENOG4105CUB amino acid AERYTH_15065 ENOG4107YZX Universal stress protein AERYTH_15080 ENOG4105D7A ATP-binding protein AERYTH_15115 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AERYTH_15125 ENOG4105SHT UspA domain-containing protein AERYTH_15135 ENOG41065SU Two-component system sensor kinase AERYTH_15170 ENOG4105CQB FAD linked oxidase domain protein AERYTH_15190 ENOG41090U3 tautomerase AERYTH_15200 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AERYTH_15215 ENOG4105CAT Cytidine monophosphate kinase AERYTH_15230 ENOG4108IGT Dipeptidase AERYTH_15235 ENOG4105CEY Amp-dependent synthetase and ligase AERYTH_15255 ENOG4108UZX fmn reductase AERYTH_15260 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AERYTH_15270 ENOG4108Z6B deaminase AERYTH_15275 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AERYTH_15285 ENOG4105EF1 ribulokinase AERYTH_15290 ENOG4105ETE Transcriptional regulator (LacI family AERYTH_15295 ENOG41062B0 ABC transporter, permease AERYTH_15300 ENOG4107R9N ABC transporter AERYTH_15305 ENOG4105C2J ABC transporter AERYTH_15310 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AERYTH_15315 ENOG4105QE3 oxidoreductase AERYTH_15320 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AERYTH_15370 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AERYTH_15375 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AERYTH_15410 ENOG4107SIQ Naphthoate synthase AERYTH_15440 ENOG4105FDF Could be involved in DNA repair (By similarity) AERYTH_15450 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AERYTH_15455 ENOG4105BZP glycoside hydrolase 15-related AERYTH_15510 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AERYTH_15535 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AERYTH_15565 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AERYTH_15570 ENOG4105D7N magnesium and cobalt transport protein CorA AERYTH_15610 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AERYTH_15635 ENOG4105D3Q Sugar transferase AERYTH_15650 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AERYTH_15655 ENOG4105FAW cDP-glucose 4,6-dehydratase AERYTH_15680 ENOG4105K64 Glycosyl transferase, family 2 AERYTH_15690 ENOG4105CK5 oxidoreductase AERYTH_15705 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AERYTH_15725 ENOG4105VC4 domain protein AERYTH_15735 ENOG4108JQ7 (ABC) transporter AERYTH_15745 ENOG4105DEF Extracellular solute-binding protein, family 5 AERYTH_15805 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AERYTH_15820 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AERYTH_15825 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AERYTH_15860 ENOG4106A3M Cytochrome p-450 AERYTH_15870 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AERYTH_15880 ENOG4105Q56 cytochrome P450 AERYTH_15890 ENOG4105HD6 methyltransferase AERYTH_15895 ENOG4105CPC Aldo Keto reductase AERYTH_15900 ENOG4108K6T Protein of unknown function (DUF1205) AERYTH_15910 ENOG4107SQU synthase AERYTH_15920 ENOG4107EEY synthase AERYTH_15970 ENOG4107W7X Aldolase AERYTH_15990 ENOG4108UT2 hemolysin iii AERYTH_16015 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AERYTH_16020 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AERYTH_16030 ENOG4108VC7 Protein of unknown function (DUF2587) AERYTH_16040 ENOG4108KP7 hydrolase AERYTH_16045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AERYTH_16060 ENOG4105CKW Inner membrane protein yedI AERYTH_16065 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AERYTH_16085 ENOG4108RMH femAB family AERYTH_16095 ENOG4105BZ4 penicillin-binding protein AERYTH_16105 ENOG4105CZA synthase AERYTH_16110 ENOG4107TE5 Lipid kinase AERYTH_16115 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AERYTH_16150 ENOG4105CPC Aldo Keto reductase AERYTH_16175 ENOG4105CG3 alpha amylase, catalytic region AERYTH_16190 ENOG4105CEU Arginine dihydrolase AERYTH_16215 ENOG4105VFE sira family AERYTH_16220 ENOG4108426 dNA-binding protein AERYTH_16225 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AERYTH_16290 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AERYTH_16300 ENOG4107QX3 carboxylase AERYTH_16310 ENOG4108594 Permease of the drug metabolite transporter AERYTH_16325 ENOG4105C57 major facilitator superfamily AERYTH_16335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AERYTH_16340 ENOG4105NAE bifunctional deaminase-reductase domain protein AERYTH_16350 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AERYTH_16370 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AERYTH_16375 ENOG4107RKG DJ-1/PfpI family AERYTH_16390 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AERYTH_16400 ENOG4105EE1 crotonyl-CoA reductase AERYTH_16420 ENOG4105SHT UspA domain-containing protein AERYTH_16495 ENOG4105TV9 FHA Domain-Containing protein AERYTH_16500 ENOG4105HZM Fha domain containing protein AERYTH_16515 ENOG4105CJN penicillin-binding protein AERYTH_16530 ENOG4105ZJT Cell division protein CrgA AERYTH_16540 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AERYTH_16565 ENOG4107VFM Dehydrogenase AERYTH_16570 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AERYTH_16595 ENOG4105CGU Enoyl-CoA hydratase AERYTH_16600 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AERYTH_16610 ENOG4105BZU Histidine kinase AERYTH_16645 ENOG4105CGD Nad-dependent epimerase dehydratase AERYTH_16650 ENOG4105CUB amino acid AERYTH_16660 ENOG4105E0A ABC, transporter AERYTH_16665 ENOG4105TVJ transport system, permease AERYTH_16670 ENOG4105DQ5 transport system permease protein AERYTH_16690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AERYTH_16695 ENOG4105CHU acetyl-coa acetyltransferase AERYTH_16705 ENOG4105DU1 integral membrane protein, terc AERYTH_16715 ENOG410846T CoA-transferase family III AERYTH_16750 ENOG4108QER Adenylate cyclase AERYTH_16775 ENOG4105E5Q amino acid AbC transporter AERYTH_16780 ENOG4105EAB amino acid AbC transporter AERYTH_16800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AERYTH_16805 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AERYTH_16810 ENOG4107TE5 Lipid kinase AERYTH_16815 ENOG4105Y3U Transglycosylase-associated protein AERYTH_16825 ENOG4105JAB phenazine biosynthesis protein, phzf family AERYTH_16855 ENOG4108JQ1 Dehydrogenase AERYTH_16875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AERYTH_16905 ENOG4105BZU Histidine kinase AERYTH_16910 ENOG4105WH1 Two component transcriptional regulator luxr family AERYTH_16945 ENOG4105VPX protein, conserved in bacteria AERYTH_16970 ENOG41080T7 secreted protein AERYTH_16975 ENOG4105DBE peroxidase AERYTH_17020 ENOG4105BZ1 (ABC) transporter AERYTH_17025 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AERYTH_17040 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AERYTH_17045 ENOG4107T5V SNARE associated Golgi AERYTH_17060 ENOG4105DR5 peptidase AERYTH_17065 ENOG4105QVC MOSC domain-containing protein AERYTH_17070 ENOG4105CDU Replicative dna helicase AERYTH_17090 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AERYTH_17095 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AERYTH_17100 ENOG4107YH6 single-stranded DNA-binding protein AERYTH_17105 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) AERYTH_17120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AERYTH_17130 ENOG4105CPC Aldo Keto reductase AERYTH_17180 ENOG4105C3M thioredoxin reductase AERYTH_17185 ENOG4105K63 Thioredoxin AERYTH_17195 ENOG4107QJE Chromosome Partitioning Protein AERYTH_17200 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AERYTH_17210 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins