locus-tag	class	description
AERYTH_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AERYTH_00010	COG0592	DNA-directed DNA polymerase activity
AERYTH_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AERYTH_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AERYTH_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AERYTH_00040	COG0187	DNA topoisomerase II activity
AERYTH_00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AERYTH_00090	COG1131	(ABC) transporter
AERYTH_00095	COG0842	Transport permease protein
AERYTH_00100	COG4585	Histidine kinase
AERYTH_00105	COG2197	response regulator
AERYTH_00160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AERYTH_00195	COG4172	Belongs to the ABC transporter superfamily
AERYTH_00200	COG0601	transmembrane transport
AERYTH_00205	COG4533	DNA binding
AERYTH_00220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AERYTH_00235	COG1024	Enoyl-CoA hydratase
AERYTH_00245	COG0705	Rhomboid family
AERYTH_00250	COG0300	oxidoreductase activity
AERYTH_00270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AERYTH_00355	COG1960	acyl-CoA dehydrogenase activity
AERYTH_00360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AERYTH_00395	COG0179	Fumarylacetoacetate (FAA) hydrolase
AERYTH_00425	COG0477	Major facilitator Superfamily
AERYTH_00435	COG5002	protein histidine kinase activity
AERYTH_00445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AERYTH_00450	COG3654	unkown
AERYTH_00480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AERYTH_00490	COG0745	RESPONSE REGULATOR receiver
AERYTH_00500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AERYTH_00505	COG1950	PFAM Membrane protein of
AERYTH_00515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AERYTH_00530	COG0022	dehydrogenase e1 component
AERYTH_00535	COG0508	dehydrogenase complex catalyzes the overall conversion of
AERYTH_00545	COG3619	membrane
AERYTH_00555	COG0154	amidase activity
AERYTH_00565	COG2351	hydroxyisourate hydrolase activity
AERYTH_00575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AERYTH_00580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AERYTH_00585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AERYTH_00600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AERYTH_00600	COG2080	2 iron, 2 sulfur cluster binding
AERYTH_00610	COG0590	tRNA wobble adenosine to inosine editing
AERYTH_00675	COG1960	acyl-CoA dehydrogenase activity
AERYTH_00720	COG0004	ammonium transporteR
AERYTH_00735	COG0789	Transcriptional regulator
AERYTH_00740	COG0659	secondary active sulfate transmembrane transporter activity
AERYTH_00745	COG0640	Transcriptional regulator
AERYTH_00750	COG0798	PFAM Bile acid sodium symporter
AERYTH_00760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AERYTH_00765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AERYTH_00800	COG0717	Belongs to the dCTP deaminase family
AERYTH_00805	COG2313	pseudouridylate synthase activity
AERYTH_00810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AERYTH_00825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AERYTH_00830	COG2181	nitrate reductase activity
AERYTH_00830	COG0247	lactate metabolic process
AERYTH_00835	COG2271	Major facilitator Superfamily
AERYTH_00875	COG1122	ATPase activity
AERYTH_00925	COG0154	amidase activity
AERYTH_00960	COG0667	Aldo Keto reductase
AERYTH_00970	COG4867	von Willebrand factor, type A
AERYTH_00980	COG0577	efflux transmembrane transporter activity
AERYTH_00980	COG1136	(ABC) transporter
AERYTH_00990	COG2197	response regulator
AERYTH_00995	COG4585	Histidine kinase
AERYTH_01005	COG0443	Heat shock 70 kDa protein
AERYTH_01010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AERYTH_01015	COG0484	heat shock protein binding
AERYTH_01020	COG0789	Transcriptional regulator
AERYTH_01100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AERYTH_01125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AERYTH_01165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AERYTH_01225	COG1017	nitric oxide dioxygenase activity
AERYTH_01225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AERYTH_01230	COG0542	response to heat
AERYTH_01245	COG0446	pyridine nucleotide-disulphide oxidoreductase
AERYTH_01270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AERYTH_01270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AERYTH_01270	COG1703	isobutyryl-CoA mutase activity
AERYTH_01290	COG2610	gluconate transmembrane transporter activity
AERYTH_01310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AERYTH_01330	COG3845	ABC transporter
AERYTH_01345	COG2045	Belongs to the ComB family
AERYTH_01415	COG1960	acyl-CoA dehydrogenase activity
AERYTH_01445	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_01465	COG2890	protein-(glutamine-N5) methyltransferase activity
AERYTH_01520	COG1960	acyl-CoA dehydrogenase activity
AERYTH_01525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AERYTH_01535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AERYTH_01540	COG0583	DNA-binding transcription factor activity
AERYTH_01575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AERYTH_01590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AERYTH_01605	COG1181	Belongs to the D-alanine--D-alanine ligase family
AERYTH_01650	COG1408	metallophosphoesterase
AERYTH_01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AERYTH_01715	COG0477	Major facilitator Superfamily
AERYTH_01725	COG0438	transferase activity, transferring glycosyl groups
AERYTH_01735	COG1116	anion transmembrane transporter activity
AERYTH_01745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AERYTH_01755	COG0588	phosphoglycerate mutase activity
AERYTH_01785	COG1329	Transcriptional regulator
AERYTH_01790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AERYTH_01800	COG0215	cysteine-tRNA ligase activity
AERYTH_01810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AERYTH_01815	COG3619	membrane
AERYTH_01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_01890	COG2318	DinB family
AERYTH_01900	COG1937	Protein conserved in bacteria
AERYTH_01925	COG0156	8-amino-7-oxononanoate synthase activity
AERYTH_01930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AERYTH_01935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AERYTH_01945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AERYTH_01975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AERYTH_01980	COG2218	PFAM glutamate synthase alpha subunit domain protein
AERYTH_01985	COG0069	glutamate synthase activity
AERYTH_02000	COG1396	sequence-specific DNA binding
AERYTH_02005	COG0183	Belongs to the thiolase family
AERYTH_02010	COG0318	PFAM AMP-dependent synthetase and ligase
AERYTH_02015	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_02030	COG1129	ABC transporter
AERYTH_02035	COG1172	Belongs to the binding-protein-dependent transport system permease family
AERYTH_02040	COG1024	Enoyl-CoA hydratase
AERYTH_02050	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_02070	COG2130	NADP-dependent
AERYTH_02100	COG1253	flavin adenine dinucleotide binding
AERYTH_02145	COG0438	transferase activity, transferring glycosyl groups
AERYTH_02175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AERYTH_02190	COG0254	rRNA binding
AERYTH_02195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AERYTH_02200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AERYTH_02205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AERYTH_02235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AERYTH_02250	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AERYTH_02290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AERYTH_02300	COG1278	Cold shock
AERYTH_02330	COG0459	protein refolding
AERYTH_02340	COG0110	maltose O-acetyltransferase activity
AERYTH_02350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AERYTH_02355	COG2011	ABC-type metal ion transport system permease component
AERYTH_02360	COG3483	tryptophan 2,3-dioxygenase activity
AERYTH_02365	COG1984	allophanate hydrolase subunit 2
AERYTH_02370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AERYTH_02375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AERYTH_02385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AERYTH_02390	COG0459	protein refolding
AERYTH_02410	COG3832	glyoxalase III activity
AERYTH_02460	COG0516	GMP reductase activity
AERYTH_02475	COG2837	iron assimilation
AERYTH_02480	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_02495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AERYTH_02505	COG0519	Catalyzes the synthesis of GMP from XMP
AERYTH_02505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AERYTH_02510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AERYTH_02515	COG0405	Gamma-glutamyltransferase
AERYTH_02545	COG4067	protein conserved in archaea
AERYTH_02545	COG0189	ligase activity
AERYTH_02550	COG0569	domain protein
AERYTH_02550	COG0189	ligase activity
AERYTH_02560	COG1902	pentaerythritol trinitrate reductase activity
AERYTH_02580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AERYTH_02610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AERYTH_02615	COG2409	Drug exporters of the RND superfamily
AERYTH_02620	COG1846	Transcriptional regulator
AERYTH_02625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AERYTH_02670	COG1309	transcriptional regulator
AERYTH_02685	COG0778	Nitroreductase
AERYTH_02705	COG1125	glycine betaine transport
AERYTH_02705	COG0517	IMP dehydrogenase activity
AERYTH_02710	COG1174	glycine betaine transport
AERYTH_02725	COG2267	carboxylic ester hydrolase activity
AERYTH_02730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AERYTH_02760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AERYTH_02785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AERYTH_02790	COG0708	Exodeoxyribonuclease III
AERYTH_02795	COG1320	monovalent cation:proton antiporter activity
AERYTH_02820	COG2111	Na H antiporter
AERYTH_02820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AERYTH_02830	COG0037	tRNA processing
AERYTH_02845	COG0302	gtp cyclohydrolase
AERYTH_02850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AERYTH_02860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AERYTH_02890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AERYTH_02895	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AERYTH_02900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AERYTH_02915	COG3237	CsbD-like
AERYTH_02930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AERYTH_02945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AERYTH_02950	COG1349	DNA-binding transcription factor activity
AERYTH_02970	COG0542	response to heat
AERYTH_03025	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AERYTH_03030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AERYTH_03045	COG0248	Ppx GppA phosphatase
AERYTH_03050	COG1082	Xylose isomerase domain protein TIM barrel
AERYTH_03055	COG1280	lysine exporter protein (LysE YggA)
AERYTH_03065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AERYTH_03070	COG0123	including yeast histone deacetylase and acetoin utilization protein
AERYTH_03095	COG1595	DNA-templated transcription, initiation
AERYTH_03100	COG0560	Phosphoserine phosphatase
AERYTH_03105	COG0318	PFAM AMP-dependent synthetase and ligase
AERYTH_03115	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AERYTH_03120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AERYTH_03125	COG0181	hydroxymethylbilane synthase activity
AERYTH_03130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AERYTH_03130	COG1648	precorrin-2 dehydrogenase activity
AERYTH_03135	COG0113	porphobilinogen synthase activity
AERYTH_03140	COG2826	transposase and inactivated derivatives, IS30 family
AERYTH_03150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AERYTH_03155	COG0406	alpha-ribazole phosphatase activity
AERYTH_03165	COG0785	Cytochrome C biogenesis protein
AERYTH_03175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AERYTH_03195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AERYTH_03220	COG0702	epimerase
AERYTH_03225	COG4948	Mandelate Racemase Muconate Lactonizing
AERYTH_03230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AERYTH_03250	COG2226	methyltransferase
AERYTH_03260	COG0640	Transcriptional regulator
AERYTH_03270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AERYTH_03275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AERYTH_03280	COG0649	NAD binding
AERYTH_03295	COG1034	ATP synthesis coupled electron transport
AERYTH_03300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AERYTH_03305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AERYTH_03315	COG0713	ATP synthesis coupled electron transport
AERYTH_03320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AERYTH_03330	COG1007	ATP synthesis coupled electron transport
AERYTH_03365	COG1666	GTP binding
AERYTH_03405	COG1522	sequence-specific DNA binding
AERYTH_03425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AERYTH_03450	COG3842	ATPase activity
AERYTH_03455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AERYTH_03460	COG1176	ABC-type spermidine putrescine transport system, permease component I
AERYTH_03465	COG1177	transmembrane transport
AERYTH_03470	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_03475	COG0167	dihydroorotate dehydrogenase activity
AERYTH_03490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AERYTH_03495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AERYTH_03505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AERYTH_03525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AERYTH_03535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AERYTH_03540	COG0081	regulation of translation
AERYTH_03545	COG5002	protein histidine kinase activity
AERYTH_03580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AERYTH_03585	COG0222	ribosome binding
AERYTH_03595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AERYTH_03600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AERYTH_03645	COG0085	RNA polymerase activity
AERYTH_03650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AERYTH_03660	COG0494	nUDIX hydrolase
AERYTH_03680	COG0277	FAD linked oxidase domain protein
AERYTH_03680	COG0247	lactate metabolic process
AERYTH_03695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AERYTH_03700	COG0151	Belongs to the GarS family
AERYTH_03710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AERYTH_03715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AERYTH_03720	COG0318	PFAM AMP-dependent synthetase and ligase
AERYTH_03730	COG2084	Dehydrogenase
AERYTH_03735	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AERYTH_03740	COG0047	phosphoribosylformylglycinamidine synthase activity
AERYTH_03755	COG0513	Belongs to the DEAD box helicase family
AERYTH_03770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AERYTH_03785	COG4303	Ethanolamine ammonia lyase large subunit
AERYTH_03790	COG0531	amino acid
AERYTH_03800	COG0584	glycerophosphoryl diester phosphodiesterase
AERYTH_03820	COG2197	response regulator
AERYTH_03830	COG0025	NhaP-type Na H and K H
AERYTH_03835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AERYTH_03845	COG1725	Transcriptional regulator
AERYTH_03870	COG0045	succinate-CoA ligase (ADP-forming) activity
AERYTH_03895	COG0138	bifunctional purine biosynthesis protein purh
AERYTH_03915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AERYTH_03930	COG0039	L-malate dehydrogenase activity
AERYTH_03940	COG2838	Isocitrate dehydrogenase
AERYTH_03945	COG2814	Major facilitator Superfamily
AERYTH_03965	COG4208	sulfate ABC transporter
AERYTH_03975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AERYTH_04000	COG0077	Prephenate dehydratase
AERYTH_04000	COG1605	Chorismate mutase
AERYTH_04005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AERYTH_04010	COG0180	Tryptophanyl-tRNA synthetase
AERYTH_04030	COG0583	DNA-binding transcription factor activity
AERYTH_04040	COG1053	succinate dehydrogenase
AERYTH_04065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AERYTH_04065	COG1473	amidohydrolase
AERYTH_04110	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_04115	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_04120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AERYTH_04125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AERYTH_04165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AERYTH_04170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AERYTH_04175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AERYTH_04195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AERYTH_04230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AERYTH_04240	COG1278	Cold shock
AERYTH_04260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AERYTH_04265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AERYTH_04270	COG0667	Aldo Keto reductase
AERYTH_04290	COG1162	GTPase activity
AERYTH_04305	COG2353	YceI-like domain
AERYTH_04315	COG1960	acyl-CoA dehydrogenase activity
AERYTH_04320	COG0183	Belongs to the thiolase family
AERYTH_04325	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_04330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AERYTH_04335	COG0736	holo-[acyl-carrier-protein] synthase activity
AERYTH_04360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AERYTH_04365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AERYTH_04380	COG0668	transmembrane transport
AERYTH_04395	COG2226	methyltransferase
AERYTH_04400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AERYTH_04415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AERYTH_04415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AERYTH_04420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AERYTH_04430	COG0243	molybdopterin cofactor binding
AERYTH_04435	COG2223	nitrite transmembrane transporter activity
AERYTH_04440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AERYTH_04460	COG2208	phosphoserine phosphatase activity
AERYTH_04460	COG2770	Histidine kinase
AERYTH_04490	COG1902	pentaerythritol trinitrate reductase activity
AERYTH_04530	COG1295	ribonuclease BN
AERYTH_04535	COG4565	transcriptional regulatory protein
AERYTH_04540	COG3290	protein histidine kinase activity
AERYTH_04560	COG0589	response to stress
AERYTH_04575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AERYTH_04625	COG2124	cytochrome p450
AERYTH_04635	COG0723	plastoquinol--plastocyanin reductase activity
AERYTH_04665	COG0455	bacterial-type flagellum organization
AERYTH_04685	COG3239	Fatty acid desaturase
AERYTH_04725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AERYTH_04730	COG0084	hydrolase, TatD family'
AERYTH_04735	COG3583	domain protein
AERYTH_04740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AERYTH_04745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AERYTH_04750	COG0488	(ABC) transporter
AERYTH_04765	COG4106	trans-aconitate 2-methyltransferase activity
AERYTH_04780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AERYTH_04785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AERYTH_04820	COG2205	protein histidine kinase activity
AERYTH_04825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AERYTH_04830	COG0193	aminoacyl-tRNA hydrolase activity
AERYTH_04860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AERYTH_04865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_04880	COG2385	sporulation resulting in formation of a cellular spore
AERYTH_04890	COG4770	biotin carboxylase activity
AERYTH_04895	COG1960	acyl-CoA dehydrogenase activity
AERYTH_04905	COG0424	maF-like protein
AERYTH_04920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AERYTH_04925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AERYTH_04925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AERYTH_04935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AERYTH_04940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AERYTH_04950	COG0579	oxidoreductase
AERYTH_04980	COG1316	TRANSCRIPTIONal
AERYTH_04995	COG1388	LysM domain
AERYTH_04995	COG1134	teichoic acid transport
AERYTH_05040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AERYTH_05045	COG0745	RESPONSE REGULATOR receiver
AERYTH_05050	COG5002	protein histidine kinase activity
AERYTH_05055	COG5401	PFAM Sporulation and spore germination
AERYTH_05065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AERYTH_05070	COG2197	response regulator
AERYTH_05075	COG3214	Protein conserved in bacteria
AERYTH_05080	COG0653	protein targeting
AERYTH_05130	COG1842	Phage shock protein A
AERYTH_05140	COG0463	Glycosyl transferase, family 2
AERYTH_05145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AERYTH_05150	COG2205	protein histidine kinase activity
AERYTH_05155	COG0745	RESPONSE REGULATOR receiver
AERYTH_05165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AERYTH_05230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AERYTH_05235	COG3546	catalase activity
AERYTH_05250	COG0537	adenosine 5'-monophosphoramidase activity
AERYTH_05255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AERYTH_05270	COG1120	ATPase activity
AERYTH_05275	COG2318	DinB family
AERYTH_05285	COG2884	Cell division ATP-binding protein ftsE
AERYTH_05300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AERYTH_05310	COG0477	Major facilitator Superfamily
AERYTH_05315	COG2356	endonuclease I
AERYTH_05350	COG4221	oxidoreductase activity
AERYTH_05365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AERYTH_05370	COG1121	(ABC) transporter
AERYTH_05380	COG0803	Belongs to the bacterial solute-binding protein 9 family
AERYTH_05405	COG2154	pterin-4-alpha-carbinolamine dehydratase
AERYTH_05415	COG2072	flavoprotein involved in K transport
AERYTH_05435	COG1470	cell adhesion involved in biofilm formation
AERYTH_05440	COG1309	transcriptional regulator
AERYTH_05455	COG1678	Uncharacterized ACR, COG1678
AERYTH_05490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_05495	COG1335	isochorismatase
AERYTH_05505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AERYTH_05520	COG0666	response to abiotic stimulus
AERYTH_05525	COG1802	Transcriptional regulator
AERYTH_05545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AERYTH_05555	COG0765	amino acid transport
AERYTH_05560	COG1126	abc transporter atp-binding protein
AERYTH_05565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AERYTH_05570	COG1234	tRNA 3'-trailer cleavage
AERYTH_05575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AERYTH_05580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AERYTH_05590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AERYTH_05620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AERYTH_05625	COG4129	membrane
AERYTH_05645	COG2301	Belongs to the HpcH HpaI aldolase family
AERYTH_05655	COG2171	N-acyltransferase activity
AERYTH_05665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AERYTH_05675	COG4221	oxidoreductase activity
AERYTH_05680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AERYTH_05685	COG1611	Belongs to the LOG family
AERYTH_05695	COG0519	Catalyzes the synthesis of GMP from XMP
AERYTH_05715	COG4122	O-methyltransferase activity
AERYTH_05720	COG1595	DNA-templated transcription, initiation
AERYTH_05730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AERYTH_05745	COG2239	Acts as a magnesium transporter
AERYTH_05755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AERYTH_05765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AERYTH_05765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AERYTH_05795	COG1960	acyl-CoA dehydrogenase activity
AERYTH_05815	COG2030	dehydratase
AERYTH_05820	COG0406	alpha-ribazole phosphatase activity
AERYTH_05825	COG0613	PHP domain protein
AERYTH_05845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AERYTH_05855	COG0300	oxidoreductase activity
AERYTH_05860	COG1192	Involved in chromosome partitioning
AERYTH_05865	COG0513	Belongs to the DEAD box helicase family
AERYTH_05885	COG1309	transcriptional regulator
AERYTH_05900	COG0210	DNA helicase
AERYTH_05935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AERYTH_05965	COG3480	Lon protease (S16) C-terminal proteolytic domain
AERYTH_05975	COG1615	UPF0182 protein
AERYTH_06030	COG2409	Drug exporters of the RND superfamily
AERYTH_06095	COG2801	Transposase and inactivated derivatives
AERYTH_06095	COG3415	Transposase
AERYTH_06105	COG0745	RESPONSE REGULATOR receiver
AERYTH_06135	COG3158	transport of potassium into the cell
AERYTH_06195	COG0754	glutathionylspermidine amidase activity
AERYTH_06220	COG1216	Glycosyl transferase, family 2
AERYTH_06230	COG0586	Pfam SNARE associated Golgi protein
AERYTH_06240	COG2409	Drug exporters of the RND superfamily
AERYTH_06250	COG2010	Cytochrome c
AERYTH_06250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AERYTH_06255	COG2080	2 iron, 2 sulfur cluster binding
AERYTH_06260	COG3608	succinylglutamate desuccinylase aspartoacylase
AERYTH_06260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AERYTH_06290	COG3781	membrane
AERYTH_06295	COG0657	acetylesterase activity
AERYTH_06340	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_06375	COG1690	Belongs to the RtcB family
AERYTH_06410	COG3177	Filamentation induced by cAMP protein fic
AERYTH_06420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AERYTH_06440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AERYTH_06460	COG2135	peptidase activity
AERYTH_06465	COG1595	DNA-templated transcription, initiation
AERYTH_06485	COG1132	(ABC) transporter
AERYTH_06520	COG0604	alcohol dehydrogenase
AERYTH_06540	COG0508	dehydrogenase complex catalyzes the overall conversion of
AERYTH_06540	COG0567	Dehydrogenase, E1 component
AERYTH_06555	COG2066	Belongs to the glutaminase family
AERYTH_06560	COG1764	response to oxidative stress
AERYTH_06570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_06595	COG0018	arginyl-trna synthetase
AERYTH_06600	COG0019	diaminopimelate decarboxylase activity
AERYTH_06620	COG0789	Transcriptional regulator
AERYTH_06630	COG0460	homoserine dehydrogenase
AERYTH_06635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AERYTH_06640	COG0083	homoserine kinase activity
AERYTH_06650	COG0386	Belongs to the glutathione peroxidase family
AERYTH_06655	COG0254	rRNA binding
AERYTH_06660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AERYTH_06665	COG2890	protein-(glutamine-N5) methyltransferase activity
AERYTH_06680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AERYTH_06690	COG0356	it plays a direct role in the translocation of protons across the membrane
AERYTH_06695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AERYTH_06700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AERYTH_06705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AERYTH_06710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AERYTH_06715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AERYTH_06720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AERYTH_06725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AERYTH_06770	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AERYTH_06780	COG1250	3-hydroxyacyl-CoA dehydrogenase
AERYTH_06815	COG0583	DNA-binding transcription factor activity
AERYTH_06820	COG0183	Belongs to the thiolase family
AERYTH_06825	COG1703	isobutyryl-CoA mutase activity
AERYTH_06850	COG0494	nUDIX hydrolase
AERYTH_06855	COG0366	Alpha amylase catalytic
AERYTH_06880	COG2086	electron transfer activity
AERYTH_06885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AERYTH_06890	COG0747	negative chemotaxis
AERYTH_06900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AERYTH_06905	COG4172	Belongs to the ABC transporter superfamily
AERYTH_06915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AERYTH_06920	COG0587	DNA-directed DNA polymerase activity
AERYTH_06940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AERYTH_06945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AERYTH_06955	COG1104	cysteine desulfurase activity
AERYTH_06965	COG0482	sulfurtransferase activity
AERYTH_06975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AERYTH_06980	COG2326	polyphosphate kinase activity
AERYTH_06985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AERYTH_06990	COG0154	amidase activity
AERYTH_06995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AERYTH_07005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AERYTH_07030	COG0129	dihydroxy-acid dehydratase activity
AERYTH_07045	COG0440	acetolactate synthase activity
AERYTH_07050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AERYTH_07060	COG0352	thiamine-phosphate diphosphorylase activity
AERYTH_07065	COG0351	phosphomethylpyrimidine kinase
AERYTH_07070	COG0352	thiamine-phosphate diphosphorylase activity
AERYTH_07070	COG0351	phosphomethylpyrimidine kinase
AERYTH_07070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AERYTH_07075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AERYTH_07080	COG2364	Membrane
AERYTH_07090	COG0473	3-isopropylmalate dehydrogenase activity
AERYTH_07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AERYTH_07105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AERYTH_07130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AERYTH_07140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AERYTH_07185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AERYTH_07210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AERYTH_07215	COG1121	(ABC) transporter
AERYTH_07220	COG0803	Belongs to the bacterial solute-binding protein 9 family
AERYTH_07225	COG0423	glycine-tRNA ligase activity
AERYTH_07260	COG0824	Thioesterase
AERYTH_07280	COG1271	oxidase subunit
AERYTH_07285	COG1294	oxidase, subunit
AERYTH_07290	COG4988	ABC transporter
AERYTH_07315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AERYTH_07340	COG1024	Enoyl-CoA hydratase
AERYTH_07345	COG0228	four-way junction DNA binding
AERYTH_07350	COG1837	Belongs to the UPF0109 family
AERYTH_07355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AERYTH_07360	COG0336	Belongs to the RNA methyltransferase TrmD family
AERYTH_07370	COG0335	large ribosomal subunit rRNA binding
AERYTH_07375	COG0681	Belongs to the peptidase S26 family
AERYTH_07380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AERYTH_07395	COG0792	nuclease activity
AERYTH_07400	COG0606	chelatase, subunit chli
AERYTH_07410	COG4974	Belongs to the 'phage' integrase family
AERYTH_07455	COG1196	nuclear chromosome segregation
AERYTH_07455	COG0741	lytic transglycosylase activity
AERYTH_07455	COG0739	heme binding
AERYTH_07460	COG0052	Belongs to the universal ribosomal protein uS2 family
AERYTH_07465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AERYTH_07470	COG0528	UMP kinase activity
AERYTH_07475	COG0233	cytoplasmic translational termination
AERYTH_07480	COG0575	Belongs to the CDS family
AERYTH_07490	COG2307	Protein conserved in bacteria
AERYTH_07490	COG2308	Evidence 4 Homologs of previously reported genes of
AERYTH_07505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AERYTH_07510	COG0561	phosphatase activity
AERYTH_07535	COG2197	response regulator
AERYTH_07540	COG4585	Histidine kinase
AERYTH_07545	COG1131	(ABC) transporter
AERYTH_07560	COG0750	zinc metalloprotease
AERYTH_07565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AERYTH_07585	COG0442	prolyl-tRNA aminoacylation
AERYTH_07610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AERYTH_07615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AERYTH_07620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AERYTH_07625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AERYTH_07635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AERYTH_07635	COG0515	serine threonine protein kinase
AERYTH_07645	COG2205	protein histidine kinase activity
AERYTH_07660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AERYTH_07665	COG1185	polyribonucleotide nucleotidyltransferase activity
AERYTH_07675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AERYTH_07710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AERYTH_07735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AERYTH_07740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AERYTH_07750	COG1674	ftsk spoiiie
AERYTH_07765	COG1058	Belongs to the CinA family
AERYTH_07765	COG1546	Belongs to the CinA family
AERYTH_07790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AERYTH_07795	COG2137	regulation of response to DNA damage stimulus
AERYTH_07810	COG0765	amino acid transport
AERYTH_07815	COG0765	amino acid transport
AERYTH_07825	COG1126	abc transporter atp-binding protein
AERYTH_07850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AERYTH_07865	COG2409	Drug exporters of the RND superfamily
AERYTH_07895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AERYTH_07900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AERYTH_07905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AERYTH_07915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AERYTH_07935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AERYTH_07995	COG1074	ATP-dependent DNA helicase activity
AERYTH_08000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AERYTH_08020	COG1764	response to oxidative stress
AERYTH_08050	COG0778	Nitroreductase
AERYTH_08065	COG3265	gluconokinase activity
AERYTH_08075	COG2610	gluconate transmembrane transporter activity
AERYTH_08080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AERYTH_08085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AERYTH_08090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AERYTH_08105	COG1278	Cold shock
AERYTH_08115	COG4412	M6 family metalloprotease domain protein
AERYTH_08115	COG3291	Pkd domain containing protein
AERYTH_08120	COG2814	Major facilitator Superfamily
AERYTH_08135	COG0708	Exodeoxyribonuclease III
AERYTH_08145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AERYTH_08195	COG0187	DNA topoisomerase II activity
AERYTH_08210	COG0477	Major facilitator Superfamily
AERYTH_08220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AERYTH_08240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AERYTH_08245	COG1435	thymidine kinase activity
AERYTH_08255	COG2860	membrane
AERYTH_08260	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_08295	COG0756	dUTP diphosphatase activity
AERYTH_08320	COG0569	domain protein
AERYTH_08325	COG0531	amino acid
AERYTH_08330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AERYTH_08350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AERYTH_08360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AERYTH_08375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AERYTH_08380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AERYTH_08380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AERYTH_08390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AERYTH_08390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AERYTH_08395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AERYTH_08400	COG0140	phosphoribosyl-ATP diphosphatase activity
AERYTH_08405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AERYTH_08425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AERYTH_08435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AERYTH_08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AERYTH_08450	COG5002	protein histidine kinase activity
AERYTH_08455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AERYTH_08460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AERYTH_08460	COG0072	phenylalanine-tRNA ligase activity
AERYTH_08465	COG0137	argininosuccinate synthase activity
AERYTH_08470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AERYTH_08475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AERYTH_08480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AERYTH_08490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AERYTH_08495	COG1438	arginine binding
AERYTH_08500	COG0165	Argininosuccinate lyase
AERYTH_08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AERYTH_08525	COG1846	Transcriptional regulator
AERYTH_08530	COG0483	inositol monophosphate 1-phosphatase activity
AERYTH_08540	COG0494	nUDIX hydrolase
AERYTH_08565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AERYTH_08585	COG3336	cytochrome c oxidase
AERYTH_08615	COG0509	glycine decarboxylation via glycine cleavage system
AERYTH_08620	COG1716	ATPase activity
AERYTH_08640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AERYTH_08640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AERYTH_08680	COG1595	DNA-templated transcription, initiation
AERYTH_08700	COG1648	precorrin-2 dehydrogenase activity
AERYTH_08700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AERYTH_08725	COG0175	sulfate reduction
AERYTH_08740	COG0009	L-threonylcarbamoyladenylate synthase
AERYTH_08765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AERYTH_08770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AERYTH_08790	COG1522	sequence-specific DNA binding
AERYTH_08815	COG0697	spore germination
AERYTH_08820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AERYTH_08830	COG0738	Major facilitator superfamily
AERYTH_08840	COG0596	Alpha beta hydrolase
AERYTH_08850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AERYTH_08880	COG1216	Glycosyl transferase, family 2
AERYTH_08900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AERYTH_08915	COG0805	protein transport
AERYTH_08940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AERYTH_08945	COG0667	Aldo Keto reductase
AERYTH_08955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AERYTH_08960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AERYTH_08970	COG4122	O-methyltransferase activity
AERYTH_08985	COG1222	aaa ATPase
AERYTH_09000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AERYTH_09025	COG0215	cysteine-tRNA ligase activity
AERYTH_09040	COG0598	Magnesium transport protein CorA
AERYTH_09075	COG0598	Magnesium transport protein CorA
AERYTH_09085	COG1968	undecaprenyl-diphosphatase activity
AERYTH_09090	COG0667	Aldo Keto reductase
AERYTH_09100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AERYTH_09110	COG0542	response to heat
AERYTH_09130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AERYTH_09140	COG2733	membrane
AERYTH_09155	COG1643	Atp-dependent helicase
AERYTH_09160	COG0545	Peptidyl-prolyl cis-trans isomerase
AERYTH_09175	COG1960	acyl-CoA dehydrogenase activity
AERYTH_09185	COG0242	peptide deformylase activity
AERYTH_09200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AERYTH_09235	COG1881	PFAM PEBP family protein
AERYTH_09250	COG1119	ATPase activity
AERYTH_09255	COG3830	Belongs to the UPF0237 family
AERYTH_09255	COG0560	Phosphoserine phosphatase
AERYTH_09260	COG3360	Dodecin
AERYTH_09275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AERYTH_09290	COG0488	(ABC) transporter
AERYTH_09295	COG2151	metal-sulfur cluster biosynthetic enzyme
AERYTH_09300	COG0822	iron-sulfur transferase activity
AERYTH_09305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AERYTH_09310	COG0396	ATPase activity
AERYTH_09345	COG2357	RelA SpoT domain protein
AERYTH_09350	COG1793	dna ligase
AERYTH_09355	COG1131	(ABC) transporter
AERYTH_09365	COG1612	heme a metabolic process
AERYTH_09375	COG0109	protoheme IX farnesyltransferase activity
AERYTH_09385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AERYTH_09405	COG0363	glucosamine-6-phosphate deaminase activity
AERYTH_09415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AERYTH_09420	COG0149	triose-phosphate isomerase activity
AERYTH_09425	COG0126	phosphoglycerate kinase activity
AERYTH_09430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AERYTH_09435	COG2890	protein-(glutamine-N5) methyltransferase activity
AERYTH_09440	COG1481	regulation of sporulation
AERYTH_09445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AERYTH_09450	COG1660	Displays ATPase and GTPase activities
AERYTH_09455	COG0322	excinuclease ABC activity
AERYTH_09465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AERYTH_09485	COG2124	cytochrome p450
AERYTH_09490	COG0531	amino acid
AERYTH_09515	COG0556	nucleotide-excision repair
AERYTH_09525	COG0183	Belongs to the thiolase family
AERYTH_09530	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_09545	COG1946	Acyl-CoA thioesterase
AERYTH_09555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AERYTH_09565	COG3540	Alkaline phosphatase
AERYTH_09570	COG1070	Carbohydrate kinase
AERYTH_09590	COG4214	carbohydrate transport
AERYTH_09600	COG4213	ABC transporter substrate-binding protein
AERYTH_09605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AERYTH_09615	COG1758	RNA polymerase activity
AERYTH_09620	COG0194	GDP metabolic process
AERYTH_09635	COG0284	orotidine-5'-phosphate decarboxylase activity
AERYTH_09640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AERYTH_09645	COG0505	Belongs to the CarA family
AERYTH_09650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AERYTH_09655	COG0540	Belongs to the ATCase OTCase family
AERYTH_09660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AERYTH_09685	COG1174	glycine betaine transport
AERYTH_09690	COG1125	glycine betaine transport
AERYTH_09690	COG0517	IMP dehydrogenase activity
AERYTH_09695	COG1174	glycine betaine transport
AERYTH_09700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AERYTH_09705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AERYTH_09715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AERYTH_09720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AERYTH_09725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AERYTH_09730	COG2076	Multidrug Resistance protein
AERYTH_09745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AERYTH_09750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AERYTH_09755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AERYTH_09785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AERYTH_09790	COG0124	histidyl-tRNA synthetase
AERYTH_09800	COG1196	nuclear chromosome segregation
AERYTH_09820	COG1215	transferase activity, transferring glycosyl groups
AERYTH_09825	COG1366	Belongs to the anti-sigma-factor antagonist family
AERYTH_09840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AERYTH_09845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AERYTH_09855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AERYTH_09860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AERYTH_09870	COG2255	four-way junction helicase activity
AERYTH_09875	COG0632	four-way junction helicase activity
AERYTH_09880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AERYTH_09885	COG0217	transcriptional regulatory protein
AERYTH_09890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AERYTH_09895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AERYTH_09905	COG3396	Phenylacetate-CoA oxygenase
AERYTH_09925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AERYTH_09940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AERYTH_09960	COG2072	flavoprotein involved in K transport
AERYTH_09975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AERYTH_09985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AERYTH_10065	COG3180	Ammonia monooxygenase
AERYTH_10070	COG2326	polyphosphate kinase activity
AERYTH_10075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AERYTH_10085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AERYTH_10100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AERYTH_10115	COG0672	)-iron permease
AERYTH_10125	COG0667	Aldo Keto reductase
AERYTH_10135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AERYTH_10170	COG0343	queuine tRNA-ribosyltransferase activity
AERYTH_10180	COG0644	oxidoreductase
AERYTH_10195	COG0237	dephospho-CoA kinase activity
AERYTH_10195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AERYTH_10215	COG0539	negative regulation of cytoplasmic translation
AERYTH_10220	COG1362	aminopeptidase activity
AERYTH_10245	COG0500	methyltransferase
AERYTH_10250	COG0438	transferase activity, transferring glycosyl groups
AERYTH_10275	COG1811	Na channel or pump
AERYTH_10280	COG0559	Belongs to the binding-protein-dependent transport system permease family
AERYTH_10320	COG0469	pyruvate kinase activity
AERYTH_10330	COG0070	glutamate synthase
AERYTH_10330	COG0067	glutamate synthase
AERYTH_10330	COG0069	glutamate synthase activity
AERYTH_10340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AERYTH_10345	COG0159	tryptophan synthase activity
AERYTH_10350	COG0133	tryptophan synthase activity
AERYTH_10355	COG0134	indole-3-glycerol-phosphate synthase activity
AERYTH_10395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AERYTH_10400	COG1132	(ABC) transporter
AERYTH_10405	COG1132	(ABC) transporter
AERYTH_10410	COG0107	imidazoleglycerol-phosphate synthase activity
AERYTH_10425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AERYTH_10430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AERYTH_10435	COG0131	Imidazoleglycerol-phosphate dehydratase
AERYTH_10445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AERYTH_10450	COG3135	benzoate transporter
AERYTH_10455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AERYTH_10465	COG0587	DNA-directed DNA polymerase activity
AERYTH_10510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AERYTH_10525	COG1799	cell septum assembly
AERYTH_10530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AERYTH_10540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AERYTH_10550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AERYTH_10555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AERYTH_10565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AERYTH_10570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AERYTH_10575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AERYTH_10580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AERYTH_10585	COG0768	penicillin binding
AERYTH_10595	COG0275	rRNA processing
AERYTH_10600	COG2001	Belongs to the MraZ family
AERYTH_10615	COG1231	oxidoreductase activity
AERYTH_10630	COG0515	serine threonine protein kinase
AERYTH_10630	COG2815	serine threonine protein kinase
AERYTH_10635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AERYTH_10660	COG1940	carbohydrate kinase activity
AERYTH_10665	COG1940	carbohydrate kinase activity
AERYTH_10680	COG1022	Amp-dependent synthetase and ligase
AERYTH_10710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AERYTH_10720	COG1845	cytochrome c oxidase, subunit III
AERYTH_10730	COG0723	plastoquinol--plastocyanin reductase activity
AERYTH_10735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AERYTH_10750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AERYTH_10755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AERYTH_10775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AERYTH_10785	COG0501	Belongs to the peptidase M48B family
AERYTH_10805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AERYTH_10810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AERYTH_10830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AERYTH_10835	COG0508	dehydrogenase complex catalyzes the overall conversion of
AERYTH_10850	COG0321	lipoyl(octanoyl) transferase activity
AERYTH_10860	COG4152	abc transporter atp-binding protein
AERYTH_10865	COG2197	response regulator
AERYTH_10870	COG4585	Histidine kinase
AERYTH_10875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AERYTH_10895	COG0174	glutamine synthetase
AERYTH_10920	COG1404	Belongs to the peptidase S8 family
AERYTH_10950	COG2133	pyrroloquinoline quinone binding
AERYTH_10965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AERYTH_10980	COG1063	alcohol dehydrogenase
AERYTH_11010	COG2826	transposase and inactivated derivatives, IS30 family
AERYTH_11045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AERYTH_11060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AERYTH_11070	COG3012	SEC-C Motif Domain Protein
AERYTH_11075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AERYTH_11075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AERYTH_11080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AERYTH_11110	COG2119	membrane
AERYTH_11115	COG3022	response to hydroperoxide
AERYTH_11120	COG0406	alpha-ribazole phosphatase activity
AERYTH_11120	COG0328	RNA-DNA hybrid ribonuclease activity
AERYTH_11130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AERYTH_11165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AERYTH_11225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AERYTH_11265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AERYTH_11270	COG0571	ribonuclease III activity
AERYTH_11275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AERYTH_11285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AERYTH_11290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AERYTH_11295	COG0742	ribosomal rna small subunit methyltransferase
AERYTH_11305	COG1461	Dihydroxyacetone kinase
AERYTH_11310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AERYTH_11315	COG0154	amidase activity
AERYTH_11335	COG1181	Belongs to the D-alanine--D-alanine ligase family
AERYTH_11340	COG0626	cystathionine gamma-synthase activity
AERYTH_11345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AERYTH_11360	COG0066	3-isopropylmalate dehydratase activity
AERYTH_11365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AERYTH_11370	COG1414	Transcriptional regulator
AERYTH_11400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AERYTH_11430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AERYTH_11430	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AERYTH_11435	COG0179	Fumarylacetoacetate (FAA) hydrolase
AERYTH_11440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AERYTH_11450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AERYTH_11455	COG1381	Involved in DNA repair and RecF pathway recombination
AERYTH_11465	COG2755	lipolytic protein G-D-S-L family
AERYTH_11480	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_11490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AERYTH_11495	COG0435	Glutathione S-transferase
AERYTH_11500	COG1414	Transcriptional regulator
AERYTH_11525	COG0714	Associated with various cellular activities
AERYTH_11530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AERYTH_11550	COG1796	DNA polymerase
AERYTH_11550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AERYTH_11555	COG1254	Belongs to the acylphosphatase family
AERYTH_11560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AERYTH_11575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AERYTH_11585	COG0537	adenosine 5'-monophosphoramidase activity
AERYTH_11590	COG0484	heat shock protein binding
AERYTH_11595	COG1420	regulation of RNA biosynthetic process
AERYTH_11620	COG1022	Amp-dependent synthetase and ligase
AERYTH_11630	COG0481	GTPase activity
AERYTH_11640	COG0268	Binds directly to 16S ribosomal RNA
AERYTH_11655	COG0658	competence protein
AERYTH_11655	COG2333	competence protein COMEC
AERYTH_11660	COG1555	photosystem II stabilization
AERYTH_11660	COG1596	polysaccharide export
AERYTH_11670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AERYTH_11675	COG1307	EDD domain protein, DegV family
AERYTH_11680	COG0495	leucyl-tRNA aminoacylation
AERYTH_11700	COG0569	domain protein
AERYTH_11705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AERYTH_11710	COG1216	Glycosyl transferase, family 2
AERYTH_11715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AERYTH_11720	COG1216	Glycosyl transferase, family 2
AERYTH_11735	COG0438	transferase activity, transferring glycosyl groups
AERYTH_11775	COG2089	acid synthase
AERYTH_11780	COG1083	cytidylyl-transferase
AERYTH_11795	COG3590	peptidase
AERYTH_11800	COG2814	Major facilitator Superfamily
AERYTH_11830	COG0454	-acetyltransferase
AERYTH_11840	COG0477	Major facilitator Superfamily
AERYTH_11910	COG1120	ATPase activity
AERYTH_11915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_11920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_11955	COG0799	negative regulation of ribosome biogenesis
AERYTH_11960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AERYTH_11965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AERYTH_11975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AERYTH_11985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AERYTH_11990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AERYTH_12005	COG2807	transmembrane transport
AERYTH_12030	COG0105	UTP biosynthetic process
AERYTH_12035	COG0366	Alpha amylase catalytic
AERYTH_12075	COG0285	dihydrofolate synthase activity
AERYTH_12110	COG0525	valine-tRNA ligase activity
AERYTH_12115	COG3268	Saccharopine dehydrogenase
AERYTH_12120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AERYTH_12125	COG0740	serine-type endopeptidase activity
AERYTH_12130	COG0740	serine-type endopeptidase activity
AERYTH_12135	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_12155	COG0673	inositol 2-dehydrogenase activity
AERYTH_12165	COG0673	inositol 2-dehydrogenase activity
AERYTH_12195	COG3962	Belongs to the TPP enzyme family
AERYTH_12200	COG3718	enzyme involved in inositol metabolism
AERYTH_12210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AERYTH_12215	COG1082	Xylose isomerase domain protein TIM barrel
AERYTH_12240	COG0544	peptidyl-prolyl cis-trans isomerase activity
AERYTH_12250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_12270	COG0564	pseudouridine synthase activity
AERYTH_12275	COG1160	GTP binding
AERYTH_12285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AERYTH_12300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AERYTH_12325	COG0494	nUDIX hydrolase
AERYTH_12330	COG0504	CTP synthase activity
AERYTH_12345	COG0497	DNA recombination
AERYTH_12350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AERYTH_12365	COG0647	UMP catabolic process
AERYTH_12405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AERYTH_12410	COG0521	Mo-molybdopterin cofactor biosynthetic process
AERYTH_12415	COG0315	cyclic pyranopterin monophosphate synthase activity
AERYTH_12430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AERYTH_12450	COG1970	mechanosensitive ion channel activity
AERYTH_12475	COG2133	pyrroloquinoline quinone binding
AERYTH_12535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AERYTH_12545	COG0702	epimerase
AERYTH_12575	COG0259	pyridoxamine-phosphate oxidase activity
AERYTH_12600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AERYTH_12615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AERYTH_12635	COG0488	(ABC) transporter
AERYTH_12665	COG0328	RNA-DNA hybrid ribonuclease activity
AERYTH_12695	COG0012	GTP binding
AERYTH_12725	COG0405	Gamma-glutamyltransferase
AERYTH_12740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AERYTH_12745	COG1570	exodeoxyribonuclease VII activity
AERYTH_12750	COG1722	exodeoxyribonuclease VII activity
AERYTH_12790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AERYTH_12810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AERYTH_12810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AERYTH_12815	COG0114	fumarate hydratase activity
AERYTH_12840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AERYTH_12845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AERYTH_12860	COG1331	Highly conserved protein containing a thioredoxin domain
AERYTH_12875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AERYTH_12885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AERYTH_12895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AERYTH_12905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AERYTH_12970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AERYTH_12985	COG2233	PERMEase
AERYTH_13000	COG0179	Fumarylacetoacetate (FAA) hydrolase
AERYTH_13015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AERYTH_13045	COG1643	Atp-dependent helicase
AERYTH_13060	COG1121	(ABC) transporter
AERYTH_13070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AERYTH_13090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AERYTH_13150	COG1301	dicarboxylic acid transport
AERYTH_13155	COG3290	protein histidine kinase activity
AERYTH_13160	COG4565	transcriptional regulatory protein
AERYTH_13175	COG0148	phosphopyruvate hydratase activity
AERYTH_13220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AERYTH_13230	COG2252	PERMEase
AERYTH_13250	COG2814	Major facilitator Superfamily
AERYTH_13255	COG3384	dioxygenase
AERYTH_13260	COG1278	Cold shock
AERYTH_13265	COG1295	ribonuclease BN
AERYTH_13285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AERYTH_13350	COG1012	belongs to the aldehyde dehydrogenase family
AERYTH_13365	COG1131	(ABC) transporter
AERYTH_13370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AERYTH_13390	COG0456	acetyltransferase
AERYTH_13395	COG0456	acetyltransferase
AERYTH_13395	COG1214	PFAM Peptidase M22, glycoprotease
AERYTH_13400	COG2826	transposase and inactivated derivatives, IS30 family
AERYTH_13405	COG0802	atpase or kinase
AERYTH_13415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AERYTH_13425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AERYTH_13430	COG1072	(Pantothenic acid kinase))
AERYTH_13440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AERYTH_13445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AERYTH_13450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AERYTH_13455	COG0372	Belongs to the citrate synthase family
AERYTH_13475	COG0101	tRNA pseudouridine synthase activity
AERYTH_13485	COG2890	protein-(glutamine-N5) methyltransferase activity
AERYTH_13495	COG0203	ribosomal protein L17
AERYTH_13500	COG0202	RNA polymerase activity
AERYTH_13505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AERYTH_13510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AERYTH_13515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AERYTH_13520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AERYTH_13525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AERYTH_13530	COG1522	sequence-specific DNA binding
AERYTH_13535	COG1834	amidinotransferase
AERYTH_13555	COG0563	adenylate kinase activity
AERYTH_13570	COG1841	ribosomal large subunit assembly
AERYTH_13575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AERYTH_13580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AERYTH_13585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AERYTH_13590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AERYTH_13595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AERYTH_13600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AERYTH_13605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AERYTH_13610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AERYTH_13615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AERYTH_13620	COG0255	Belongs to the universal ribosomal protein uL29 family
AERYTH_13625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AERYTH_13630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AERYTH_13635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AERYTH_13640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AERYTH_13645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AERYTH_13650	COG0089	rRNA binding
AERYTH_13655	COG0088	Forms part of the polypeptide exit tunnel
AERYTH_13660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AERYTH_13665	COG0051	transcription antitermination factor activity, RNA binding
AERYTH_13675	COG0697	spore germination
AERYTH_13680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AERYTH_13685	COG0546	phosphoglycolate phosphatase activity
AERYTH_13690	COG2313	pseudouridylate synthase activity
AERYTH_13700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AERYTH_13705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AERYTH_13710	COG0049	tRNA binding
AERYTH_13715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AERYTH_13725	COG0446	pyridine nucleotide-disulphide oxidoreductase
AERYTH_13745	COG3764	Sortase (surface protein transpeptidase)
AERYTH_13770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AERYTH_13790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AERYTH_13830	COG1302	Protein conserved in bacteria
AERYTH_13835	COG1595	DNA-templated transcription, initiation
AERYTH_13890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AERYTH_13905	COG1605	Chorismate mutase
AERYTH_13905	COG0287	Prephenate dehydrogenase
AERYTH_13915	COG0470	DNA polymerase III
AERYTH_13925	COG1754	DNA topoisomerase type I activity
AERYTH_13925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AERYTH_13930	COG2264	protein methyltransferase activity
AERYTH_13935	COG1366	Belongs to the anti-sigma-factor antagonist family
AERYTH_13940	COG1205	dead DEAH box helicase
AERYTH_13940	COG1111	helicase
AERYTH_14005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AERYTH_14020	COG3275	phosphorelay sensor kinase activity
AERYTH_14030	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AERYTH_14035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AERYTH_14085	COG0110	maltose O-acetyltransferase activity
AERYTH_14100	COG1268	BioY protein
AERYTH_14105	COG1122	ATPase activity
AERYTH_14125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AERYTH_14135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AERYTH_14140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AERYTH_14155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AERYTH_14165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AERYTH_14190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AERYTH_14215	COG0662	Cupin 2, conserved barrel domain protein
AERYTH_14215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AERYTH_14235	COG0489	protein tyrosine kinase activity
AERYTH_14250	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AERYTH_14255	COG1490	D-aminoacyl-tRNA deacylase activity
AERYTH_14290	COG3479	Phenolic acid decarboxylase
AERYTH_14310	COG0745	RESPONSE REGULATOR receiver
AERYTH_14320	COG0454	-acetyltransferase
AERYTH_14320	COG0456	acetyltransferase
AERYTH_14330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AERYTH_14360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AERYTH_14365	COG0306	phosphate transporter
AERYTH_14415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_14420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AERYTH_14425	COG1116	anion transmembrane transporter activity
AERYTH_14430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AERYTH_14435	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_14450	COG0297	glycogen (starch) synthase activity
AERYTH_14460	COG2072	flavoprotein involved in K transport
AERYTH_14505	COG3835	regulator
AERYTH_14515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AERYTH_14560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AERYTH_14565	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_14575	COG1064	alcohol dehydrogenase
AERYTH_14580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AERYTH_14585	COG1063	alcohol dehydrogenase
AERYTH_14590	COG1492	cobalamin metabolic process
AERYTH_14600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AERYTH_14605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AERYTH_14615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AERYTH_14615	COG1648	precorrin-2 dehydrogenase activity
AERYTH_14620	COG1797	cobyrinic acid a,c-diamide synthase activity
AERYTH_14625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AERYTH_14675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_14690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AERYTH_14705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AERYTH_14705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AERYTH_14710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AERYTH_14745	COG0477	Major facilitator Superfamily
AERYTH_14765	COG0702	epimerase
AERYTH_14770	COG0739	heme binding
AERYTH_14780	COG3903	Transcriptional regulator
AERYTH_14780	COG3629	intracellular signal transduction
AERYTH_14800	COG1024	Enoyl-CoA hydratase
AERYTH_14810	COG1960	acyl-CoA dehydrogenase activity
AERYTH_14830	COG2267	carboxylic ester hydrolase activity
AERYTH_14845	COG2850	peptidyl-arginine hydroxylation
AERYTH_14870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AERYTH_14950	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AERYTH_14955	COG0076	glutamate decarboxylase activity
AERYTH_14965	COG1674	ftsk spoiiie
AERYTH_15035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AERYTH_15050	COG1966	Carbon starvation protein
AERYTH_15060	COG0531	amino acid
AERYTH_15065	COG0589	response to stress
AERYTH_15080	COG0433	COG0433 Predicted ATPase
AERYTH_15115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AERYTH_15125	COG0589	response to stress
AERYTH_15135	COG2205	protein histidine kinase activity
AERYTH_15170	COG0277	FAD linked oxidase domain protein
AERYTH_15190	COG1942	4-Oxalocrotonate Tautomerase
AERYTH_15200	COG0706	membrane insertase activity
AERYTH_15215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AERYTH_15215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AERYTH_15235	COG0318	PFAM AMP-dependent synthetase and ligase
AERYTH_15255	COG0431	NADPH-dependent FMN reductase
AERYTH_15260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AERYTH_15270	COG0590	tRNA wobble adenosine to inosine editing
AERYTH_15275	COG2160	L-arabinose isomerase activity
AERYTH_15290	COG1609	Transcriptional regulator
AERYTH_15295	COG1172	Belongs to the binding-protein-dependent transport system permease family
AERYTH_15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AERYTH_15310	COG1879	ABC-type sugar transport system periplasmic component
AERYTH_15315	COG0277	FAD linked oxidase domain protein
AERYTH_15320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AERYTH_15370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AERYTH_15375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AERYTH_15410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AERYTH_15440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AERYTH_15450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AERYTH_15455	COG3387	PFAM Glycoside hydrolase 15-related
AERYTH_15465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AERYTH_15470	COG2814	Major facilitator Superfamily
AERYTH_15510	COG2095	MarC family integral membrane protein
AERYTH_15565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AERYTH_15570	COG0598	Magnesium transport protein CorA
AERYTH_15610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AERYTH_15650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AERYTH_15660	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AERYTH_15680	COG1215	transferase activity, transferring glycosyl groups
AERYTH_15690	COG0673	inositol 2-dehydrogenase activity
AERYTH_15705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AERYTH_15725	COG2827	Endonuclease containing a URI domain
AERYTH_15735	COG4608	Belongs to the ABC transporter superfamily
AERYTH_15745	COG0747	negative chemotaxis
AERYTH_15820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AERYTH_15825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AERYTH_15850	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AERYTH_15860	COG2124	cytochrome p450
AERYTH_15880	COG2124	cytochrome p450
AERYTH_15890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AERYTH_15895	COG0667	Aldo Keto reductase
AERYTH_15900	COG1819	glycosyl
AERYTH_15905	COG2124	cytochrome p450
AERYTH_15970	COG0235	Class ii aldolase
AERYTH_16015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AERYTH_16020	COG3046	protein related to deoxyribodipyrimidine photolyase
AERYTH_16025	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_16025	COG0604	alcohol dehydrogenase
AERYTH_16025	COG3321	synthase
AERYTH_16040	COG0561	phosphatase activity
AERYTH_16045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AERYTH_16060	COG2354	Protein conserved in bacteria
AERYTH_16085	COG2348	transferase activity, transferring amino-acyl groups
AERYTH_16095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AERYTH_16105	COG1260	myo-inositol-1-phosphate synthase
AERYTH_16110	COG1597	lipid kinase activity
AERYTH_16115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AERYTH_16150	COG0667	Aldo Keto reductase
AERYTH_16175	COG0366	Alpha amylase catalytic
AERYTH_16190	COG2235	arginine
AERYTH_16215	COG0425	Belongs to the sulfur carrier protein TusA family
AERYTH_16215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AERYTH_16220	COG0776	regulation of translation
AERYTH_16225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AERYTH_16300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AERYTH_16325	COG0477	Major facilitator Superfamily
AERYTH_16335	COG0584	glycerophosphoryl diester phosphodiesterase
AERYTH_16340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AERYTH_16350	COG1739	Uncharacterized protein family UPF0029
AERYTH_16375	COG0693	protein deglycase activity
AERYTH_16390	COG1136	(ABC) transporter
AERYTH_16420	COG0589	response to stress
AERYTH_16495	COG1716	ATPase activity
AERYTH_16500	COG1716	ATPase activity
AERYTH_16515	COG0768	penicillin binding
AERYTH_16520	COG0515	serine threonine protein kinase
AERYTH_16540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AERYTH_16565	COG1233	COG1233 Phytoene dehydrogenase and related
AERYTH_16570	COG2226	methyltransferase
AERYTH_16595	COG1024	Enoyl-CoA hydratase
AERYTH_16600	COG1028	Short-chain dehydrogenase reductase Sdr
AERYTH_16610	COG2200	EAL domain
AERYTH_16610	COG2199	diguanylate cyclase activity
AERYTH_16645	COG0702	epimerase
AERYTH_16650	COG0531	amino acid
AERYTH_16660	COG1120	ATPase activity
AERYTH_16665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_16670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AERYTH_16690	COG1024	Enoyl-CoA hydratase
AERYTH_16690	COG1250	3-hydroxyacyl-CoA dehydrogenase
AERYTH_16695	COG0183	Belongs to the thiolase family
AERYTH_16715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AERYTH_16750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AERYTH_16775	COG0765	amino acid transport
AERYTH_16800	COG1902	pentaerythritol trinitrate reductase activity
AERYTH_16800	COG0446	pyridine nucleotide-disulphide oxidoreductase
AERYTH_16805	COG2130	NADP-dependent
AERYTH_16815	COG2261	transglycosylase associated protein
AERYTH_16825	COG0384	phenazine biosynthesis protein PhzF
AERYTH_16855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AERYTH_16875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AERYTH_16905	COG4585	Histidine kinase
AERYTH_16910	COG2197	response regulator
AERYTH_16945	COG1937	Protein conserved in bacteria
AERYTH_16970	COG2847	Copper chaperone PCu(A)C
AERYTH_16975	COG2837	iron assimilation
AERYTH_17020	COG1132	(ABC) transporter
AERYTH_17025	COG0596	Alpha beta hydrolase
AERYTH_17040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AERYTH_17045	COG0586	Pfam SNARE associated Golgi protein
AERYTH_17060	COG0739	heme binding
AERYTH_17065	COG0633	Ferredoxin
AERYTH_17065	COG3217	Mosc domain protein beta barrel domain protein
AERYTH_17070	COG0305	Participates in initiation and elongation during chromosome replication
AERYTH_17090	COG0359	binds to the 23S rRNA
AERYTH_17095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AERYTH_17100	COG0629	single-stranded DNA binding
AERYTH_17105	COG0360	Binds together with S18 to 16S ribosomal RNA
AERYTH_17120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AERYTH_17130	COG0667	Aldo Keto reductase
AERYTH_17145	COG1305	Transglutaminase-like
AERYTH_17185	COG3118	belongs to the thioredoxin family
AERYTH_17195	COG1192	Involved in chromosome partitioning
AERYTH_17200	COG0357	Ribosomal RNA small subunit methyltransferase G
AERYTH_17210	COG0706	membrane insertase activity
AERYTH_17215	COG0594	ribonuclease P activity