locus-tag	class	description
C6I20_00125	COG1902	pentaerythritol trinitrate reductase activity
C6I20_00245	COG0542	response to heat
C6I20_00255	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6I20_00270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_00270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_00270	COG1703	isobutyryl-CoA mutase activity
C6I20_00300	COG3845	ABC transporter
C6I20_00315	COG1492	cobalamin metabolic process
C6I20_00325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C6I20_00335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6I20_00340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6I20_00355	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C6I20_00360	COG0310	cobalt ion transport
C6I20_00375	COG1797	cobyrinic acid a,c-diamide synthase activity
C6I20_00380	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C6I20_00485	COG2130	NADP-dependent
C6I20_00490	COG1643	Atp-dependent helicase
C6I20_00500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6I20_00505	COG1136	(ABC) transporter
C6I20_00510	COG0577	efflux transmembrane transporter activity
C6I20_00510	COG1136	(ABC) transporter
C6I20_00525	COG0789	Transcriptional regulator
C6I20_00530	COG0667	Aldo Keto reductase
C6I20_00560	COG2072	flavoprotein involved in K transport
C6I20_00570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6I20_00585	COG0037	tRNA processing
C6I20_00600	COG0302	gtp cyclohydrolase
C6I20_00605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6I20_00615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6I20_00635	COG0649	NAD binding
C6I20_00645	COG0463	Glycosyl transferase, family 2
C6I20_00655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6I20_00660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C6I20_00665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6I20_00670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6I20_00675	COG0542	response to heat
C6I20_00705	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C6I20_00710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6I20_00730	COG0248	Ppx GppA phosphatase
C6I20_00735	COG1082	Xylose isomerase domain protein TIM barrel
C6I20_00740	COG1280	lysine exporter protein (LysE YggA)
C6I20_00755	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6I20_00785	COG1595	DNA-templated transcription, initiation
C6I20_00790	COG0560	Phosphoserine phosphatase
C6I20_00795	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_00805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C6I20_00810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6I20_00815	COG0181	hydroxymethylbilane synthase activity
C6I20_00825	COG0113	porphobilinogen synthase activity
C6I20_00835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6I20_00840	COG0406	alpha-ribazole phosphatase activity
C6I20_00850	COG0785	Cytochrome C biogenesis protein
C6I20_00860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6I20_00865	COG1131	(ABC) transporter
C6I20_00885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6I20_00915	COG4948	Mandelate Racemase Muconate Lactonizing
C6I20_00920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C6I20_00940	COG1169	isochorismate synthase
C6I20_00945	COG2226	methyltransferase
C6I20_00950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C6I20_00960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_00965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_00970	COG0649	NAD binding
C6I20_00980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6I20_00985	COG1034	ATP synthesis coupled electron transport
C6I20_00990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6I20_00995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_01005	COG0713	ATP synthesis coupled electron transport
C6I20_01010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6I20_01020	COG1007	ATP synthesis coupled electron transport
C6I20_01040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_01045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_01050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_01060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_01065	COG0839	Belongs to the complex I subunit 6 family
C6I20_01070	COG0713	ATP synthesis coupled electron transport
C6I20_01085	COG1007	ATP synthesis coupled electron transport
C6I20_01090	COG1666	GTP binding
C6I20_01100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_01125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6I20_01160	COG3177	Filamentation induced by cAMP protein fic
C6I20_01165	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_01175	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C6I20_01180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6I20_01185	COG1942	4-Oxalocrotonate Tautomerase
C6I20_01190	COG2197	response regulator
C6I20_01205	COG0167	dihydroorotate dehydrogenase activity
C6I20_01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6I20_01225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6I20_01245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_01260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6I20_01270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6I20_01275	COG0081	regulation of translation
C6I20_01295	COG0222	ribosome binding
C6I20_01305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_01310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_01355	COG0085	RNA polymerase activity
C6I20_01360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6I20_01370	COG3594	Acyltransferase
C6I20_01375	COG1051	belongs to the nudix hydrolase family
C6I20_01395	COG0247	lactate metabolic process
C6I20_01395	COG0277	FAD linked oxidase domain protein
C6I20_01405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6I20_01410	COG0049	tRNA binding
C6I20_01415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6I20_01420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6I20_01470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_01475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6I20_01495	COG0088	Forms part of the polypeptide exit tunnel
C6I20_01500	COG0089	rRNA binding
C6I20_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6I20_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6I20_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6I20_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6I20_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6I20_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
C6I20_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6I20_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6I20_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6I20_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6I20_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6I20_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6I20_01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6I20_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6I20_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6I20_01580	COG1841	ribosomal large subunit assembly
C6I20_01585	COG0200	Binds to the 23S rRNA
C6I20_01595	COG0563	adenylate kinase activity
C6I20_01610	COG1834	amidinotransferase
C6I20_01615	COG1522	sequence-specific DNA binding
C6I20_01625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6I20_01630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6I20_01635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6I20_01640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6I20_01645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6I20_01650	COG0202	RNA polymerase activity
C6I20_01655	COG0203	ribosomal protein L17
C6I20_01665	COG0101	tRNA pseudouridine synthase activity
C6I20_01670	COG0372	Belongs to the citrate synthase family
C6I20_01675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6I20_01680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6I20_01685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6I20_01695	COG0456	acetyltransferase
C6I20_01700	COG1072	(Pantothenic acid kinase))
C6I20_01705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6I20_01710	COG0736	holo-[acyl-carrier-protein] synthase activity
C6I20_01715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6I20_01715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6I20_01720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6I20_01730	COG0802	atpase or kinase
C6I20_01735	COG1214	PFAM Peptidase M22, glycoprotease
C6I20_01735	COG0456	acetyltransferase
C6I20_01760	COG2318	DinB family
C6I20_01765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6I20_01785	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6I20_01795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6I20_01800	COG0459	protein refolding
C6I20_01805	COG0557	exoribonuclease II activity
C6I20_01825	COG0516	GMP reductase activity
C6I20_01845	COG2837	iron assimilation
C6I20_01855	COG0519	Catalyzes the synthesis of GMP from XMP
C6I20_01855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6I20_01870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_01870	COG0723	plastoquinol--plastocyanin reductase activity
C6I20_01885	COG0405	Gamma-glutamyltransferase
C6I20_01890	COG0584	glycerophosphoryl diester phosphodiesterase
C6I20_01915	COG2197	response regulator
C6I20_01920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6I20_01925	COG1725	Transcriptional regulator
C6I20_01960	COG0596	Alpha beta hydrolase
C6I20_01965	COG0045	succinate-CoA ligase (ADP-forming) activity
C6I20_01990	COG0138	bifunctional purine biosynthesis protein purh
C6I20_02000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6I20_02010	COG0039	L-malate dehydrogenase activity
C6I20_02025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6I20_02030	COG2838	Isocitrate dehydrogenase
C6I20_02040	COG2814	Major facilitator Superfamily
C6I20_02045	COG3842	ATPase activity
C6I20_02050	COG4208	sulfate ABC transporter
C6I20_02060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6I20_02090	COG1605	Chorismate mutase
C6I20_02090	COG0077	Prephenate dehydratase
C6I20_02095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6I20_02100	COG0180	Tryptophanyl-tRNA synthetase
C6I20_02120	COG1053	succinate dehydrogenase
C6I20_02125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6I20_02145	COG1473	amidohydrolase
C6I20_02145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6I20_02175	COG2124	cytochrome p450
C6I20_02190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_02200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6I20_02210	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_02215	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_02220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6I20_02225	COG0737	Belongs to the 5'-nucleotidase family
C6I20_02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6I20_02260	COG2385	sporulation resulting in formation of a cellular spore
C6I20_02270	COG4770	biotin carboxylase activity
C6I20_02275	COG1960	acyl-CoA dehydrogenase activity
C6I20_02285	COG0424	maF-like protein
C6I20_02300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_02315	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C6I20_02325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6I20_02340	COG1960	acyl-CoA dehydrogenase activity
C6I20_02345	COG0697	spore germination
C6I20_02350	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_02355	COG1960	acyl-CoA dehydrogenase activity
C6I20_02365	COG1960	acyl-CoA dehydrogenase activity
C6I20_02380	COG0517	IMP dehydrogenase activity
C6I20_02380	COG1125	glycine betaine transport
C6I20_02385	COG1174	glycine betaine transport
C6I20_02415	COG0183	Belongs to the thiolase family
C6I20_02420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6I20_02425	COG1063	alcohol dehydrogenase
C6I20_02435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_02440	COG1611	Belongs to the LOG family
C6I20_02445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6I20_02450	COG2818	Glycosylase
C6I20_02460	COG1024	Enoyl-CoA hydratase
C6I20_02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6I20_02515	COG2239	Acts as a magnesium transporter
C6I20_02535	COG0657	acetylesterase activity
C6I20_02550	COG1960	acyl-CoA dehydrogenase activity
C6I20_02560	COG2030	dehydratase
C6I20_02585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6I20_02595	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_02600	COG1192	Involved in chromosome partitioning
C6I20_02610	COG0513	Belongs to the DEAD box helicase family
C6I20_02635	COG1309	transcriptional regulator
C6I20_02655	COG0210	DNA helicase
C6I20_02675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6I20_02705	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6I20_02715	COG1615	UPF0182 protein
C6I20_02730	COG1024	Enoyl-CoA hydratase
C6I20_02735	COG1960	acyl-CoA dehydrogenase activity
C6I20_02760	COG0640	Transcriptional regulator
C6I20_02875	COG1960	acyl-CoA dehydrogenase activity
C6I20_02880	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_02905	COG1960	acyl-CoA dehydrogenase activity
C6I20_02940	COG4221	oxidoreductase activity
C6I20_02965	COG1609	Transcriptional regulator
C6I20_02995	COG1129	ABC transporter
C6I20_03000	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_03005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_03015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6I20_03050	COG0535	radical SAM domain protein
C6I20_03080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_03090	COG2197	response regulator
C6I20_03095	COG4585	Histidine kinase
C6I20_03145	COG0702	epimerase
C6I20_03185	COG1309	transcriptional regulator
C6I20_03190	COG1960	acyl-CoA dehydrogenase activity
C6I20_03210	COG1960	acyl-CoA dehydrogenase activity
C6I20_03230	COG1053	succinate dehydrogenase
C6I20_03240	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C6I20_03245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_03260	COG1960	acyl-CoA dehydrogenase activity
C6I20_03265	COG2267	carboxylic ester hydrolase activity
C6I20_03300	COG1115	amino acid carrier protein
C6I20_03305	COG1960	acyl-CoA dehydrogenase activity
C6I20_03310	COG1960	acyl-CoA dehydrogenase activity
C6I20_03315	COG1960	acyl-CoA dehydrogenase activity
C6I20_03325	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_03330	COG1960	acyl-CoA dehydrogenase activity
C6I20_03340	COG1309	transcriptional regulator
C6I20_03345	COG0183	Belongs to the thiolase family
C6I20_03385	COG1024	Enoyl-CoA hydratase
C6I20_03395	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03400	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03415	COG0604	alcohol dehydrogenase
C6I20_03415	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03415	COG3321	synthase
C6I20_03420	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_03425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6I20_03430	COG0183	Belongs to the thiolase family
C6I20_03435	COG2124	cytochrome p450
C6I20_03460	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03465	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_03480	COG2070	2-Nitropropane dioxygenase
C6I20_03485	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_03490	COG1960	acyl-CoA dehydrogenase activity
C6I20_03495	COG1960	acyl-CoA dehydrogenase activity
C6I20_03510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_03515	COG1053	succinate dehydrogenase
C6I20_03525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_03575	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03625	COG1024	Enoyl-CoA hydratase
C6I20_03630	COG2267	carboxylic ester hydrolase activity
C6I20_03645	COG2130	NADP-dependent
C6I20_03650	COG2814	Major facilitator Superfamily
C6I20_03655	COG0183	Belongs to the thiolase family
C6I20_03660	COG1024	Enoyl-CoA hydratase
C6I20_03665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_03675	COG2508	Transcriptional regulator
C6I20_03695	COG3268	Saccharopine dehydrogenase
C6I20_03700	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_03710	COG1288	antiporter activity
C6I20_03720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6I20_03740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6I20_03770	COG0406	alpha-ribazole phosphatase activity
C6I20_03775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6I20_03780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6I20_03805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6I20_03810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6I20_03840	COG2837	iron assimilation
C6I20_03875	COG2353	YceI-like domain
C6I20_03880	COG1309	transcriptional regulator
C6I20_03885	COG1960	acyl-CoA dehydrogenase activity
C6I20_03890	COG0183	Belongs to the thiolase family
C6I20_03895	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_03905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6I20_03910	COG0736	holo-[acyl-carrier-protein] synthase activity
C6I20_03920	COG3173	Aminoglycoside phosphotransferase
C6I20_03930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_03935	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6I20_03945	COG2346	COG2346, Truncated hemoglobins
C6I20_03950	COG0668	transmembrane transport
C6I20_03970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6I20_03975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6I20_04025	COG1024	Enoyl-CoA hydratase
C6I20_04035	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_04080	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6I20_04100	COG2188	Transcriptional regulator
C6I20_04105	COG1082	Xylose isomerase domain protein TIM barrel
C6I20_04110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_04120	COG3718	enzyme involved in inositol metabolism
C6I20_04125	COG3962	Belongs to the TPP enzyme family
C6I20_04135	COG1879	ABC-type sugar transport system periplasmic component
C6I20_04150	COG0673	inositol 2-dehydrogenase activity
C6I20_04155	COG0673	inositol 2-dehydrogenase activity
C6I20_04160	COG0673	inositol 2-dehydrogenase activity
C6I20_04170	COG0740	serine-type endopeptidase activity
C6I20_04175	COG0740	serine-type endopeptidase activity
C6I20_04180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6I20_04185	COG3268	Saccharopine dehydrogenase
C6I20_04190	COG1271	oxidase subunit
C6I20_04200	COG1105	Belongs to the carbohydrate kinase PfkB family
C6I20_04205	COG1349	DNA-binding transcription factor activity
C6I20_04210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6I20_04215	COG1063	alcohol dehydrogenase
C6I20_04220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6I20_04235	COG0525	valine-tRNA ligase activity
C6I20_04240	COG2409	Drug exporters of the RND superfamily
C6I20_04245	COG0285	dihydrofolate synthase activity
C6I20_04255	COG0105	UTP biosynthetic process
C6I20_04270	COG2807	transmembrane transport
C6I20_04280	COG1530	ribonuclease E activity
C6I20_04285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6I20_04290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6I20_04295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6I20_04300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6I20_04305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6I20_04310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6I20_04320	COG0406	alpha-ribazole phosphatase activity
C6I20_04355	COG0477	Major facilitator Superfamily
C6I20_04360	COG3590	peptidase
C6I20_04390	COG1216	Glycosyl transferase, family 2
C6I20_04435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6I20_04440	COG0569	domain protein
C6I20_04445	COG0495	leucyl-tRNA aminoacylation
C6I20_04450	COG1307	EDD domain protein, DegV family
C6I20_04455	COG1555	photosystem II stabilization
C6I20_04455	COG1596	polysaccharide export
C6I20_04475	COG0268	Binds directly to 16S ribosomal RNA
C6I20_04480	COG0481	GTPase activity
C6I20_04490	COG2258	MOSC domain
C6I20_04505	COG1022	Amp-dependent synthetase and ligase
C6I20_04525	COG1420	regulation of RNA biosynthetic process
C6I20_04530	COG0484	heat shock protein binding
C6I20_04535	COG0537	adenosine 5'-monophosphoramidase activity
C6I20_04545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6I20_04560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6I20_04570	COG1254	Belongs to the acylphosphatase family
C6I20_04580	COG1796	DNA polymerase
C6I20_04580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6I20_04595	COG0714	Associated with various cellular activities
C6I20_04615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_04625	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_04635	COG1381	Involved in DNA repair and RecF pathway recombination
C6I20_04640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6I20_04650	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6I20_04655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6I20_04710	COG1414	Transcriptional regulator
C6I20_04715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6I20_04720	COG0066	3-isopropylmalate dehydratase activity
C6I20_04735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6I20_04740	COG0626	cystathionine gamma-synthase activity
C6I20_04745	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6I20_04770	COG0154	amidase activity
C6I20_04775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6I20_04780	COG1461	Dihydroxyacetone kinase
C6I20_04790	COG0742	ribosomal rna small subunit methyltransferase
C6I20_04795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6I20_04800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6I20_04810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6I20_04815	COG0571	ribonuclease III activity
C6I20_04820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6I20_04825	COG0456	acetyltransferase
C6I20_04830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C6I20_04845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6I20_04860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_04910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6I20_04965	COG1937	Protein conserved in bacteria
C6I20_04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_04975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_04985	COG2409	Drug exporters of the RND superfamily
C6I20_04990	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_04995	COG0514	ATP-dependent DNA helicase (RecQ)
C6I20_05005	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_05015	COG0328	RNA-DNA hybrid ribonuclease activity
C6I20_05015	COG0406	alpha-ribazole phosphatase activity
C6I20_05020	COG3022	response to hydroperoxide
C6I20_05025	COG2119	membrane
C6I20_05065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C6I20_05080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6I20_05080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6I20_05090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6I20_05100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_05130	COG1309	transcriptional regulator
C6I20_05185	COG1937	Protein conserved in bacteria
C6I20_05190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6I20_05195	COG0596	Alpha beta hydrolase
C6I20_05200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6I20_05205	COG1216	Glycosyl transferase, family 2
C6I20_05210	COG0745	RESPONSE REGULATOR receiver
C6I20_05215	COG2205	protein histidine kinase activity
C6I20_05230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_05235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6I20_05235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6I20_05270	COG1960	acyl-CoA dehydrogenase activity
C6I20_05275	COG1960	acyl-CoA dehydrogenase activity
C6I20_05315	COG1063	alcohol dehydrogenase
C6I20_05330	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C6I20_05350	COG0174	glutamine synthetase
C6I20_05365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6I20_05385	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6I20_05405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6I20_05410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6I20_05430	COG0501	Belongs to the peptidase M48B family
C6I20_05440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6I20_05460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6I20_05465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6I20_05480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6I20_05485	COG0723	plastoquinol--plastocyanin reductase activity
C6I20_05490	COG2010	Cytochrome c
C6I20_05495	COG1845	cytochrome c oxidase, subunit III
C6I20_05505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6I20_05535	COG1022	Amp-dependent synthetase and ligase
C6I20_05550	COG1940	carbohydrate kinase activity
C6I20_05555	COG1940	carbohydrate kinase activity
C6I20_05575	COG0205	6-phosphofructokinase activity
C6I20_05585	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6I20_05605	COG0515	serine threonine protein kinase
C6I20_05605	COG2815	serine threonine protein kinase
C6I20_05615	COG2732	(Barnase) inhibitor
C6I20_05645	COG2001	Belongs to the MraZ family
C6I20_05650	COG0275	rRNA processing
C6I20_05660	COG0768	penicillin binding
C6I20_05665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6I20_05670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6I20_05675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6I20_05680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6I20_05690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6I20_05695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6I20_05715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6I20_05720	COG1799	cell septum assembly
C6I20_05735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6I20_05745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6I20_05775	COG0587	DNA-directed DNA polymerase activity
C6I20_05785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6I20_05790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6I20_05795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6I20_05800	COG0131	Imidazoleglycerol-phosphate dehydratase
C6I20_05805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6I20_05810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6I20_05815	COG0107	imidazoleglycerol-phosphate synthase activity
C6I20_05820	COG1132	(ABC) transporter
C6I20_05825	COG1132	(ABC) transporter
C6I20_05830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6I20_05865	COG0134	indole-3-glycerol-phosphate synthase activity
C6I20_05870	COG0133	tryptophan synthase activity
C6I20_05875	COG0159	tryptophan synthase activity
C6I20_05880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6I20_05890	COG0069	glutamate synthase activity
C6I20_05890	COG0070	glutamate synthase
C6I20_05890	COG0067	glutamate synthase
C6I20_05900	COG0469	pyruvate kinase activity
C6I20_05920	COG0410	ABC transporter
C6I20_05935	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6I20_05940	COG1811	Na channel or pump
C6I20_05965	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_05970	COG0277	FAD linked oxidase domain protein
C6I20_05975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6I20_05980	COG0438	transferase activity, transferring glycosyl groups
C6I20_05990	COG4981	capsule polysaccharide biosynthetic process
C6I20_06010	COG1362	aminopeptidase activity
C6I20_06015	COG0539	negative regulation of cytoplasmic translation
C6I20_06035	COG0237	dephospho-CoA kinase activity
C6I20_06040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6I20_06050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6I20_06065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6I20_06090	COG0477	Major facilitator Superfamily
C6I20_06100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6I20_06125	COG1435	thymidine kinase activity
C6I20_06135	COG2860	membrane
C6I20_06140	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_06175	COG0756	dUTP diphosphatase activity
C6I20_06200	COG0569	domain protein
C6I20_06205	COG0531	amino acid
C6I20_06210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6I20_06225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6I20_06230	COG4213	ABC transporter substrate-binding protein
C6I20_06240	COG4214	carbohydrate transport
C6I20_06245	COG1940	carbohydrate kinase activity
C6I20_06250	COG1940	carbohydrate kinase activity
C6I20_06260	COG1070	Carbohydrate kinase
C6I20_06270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6I20_06280	COG1946	Acyl-CoA thioesterase
C6I20_06300	COG0183	Belongs to the thiolase family
C6I20_06320	COG0556	nucleotide-excision repair
C6I20_06335	COG0531	amino acid
C6I20_06340	COG2124	cytochrome p450
C6I20_06355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6I20_06360	COG0322	excinuclease ABC activity
C6I20_06365	COG1660	Displays ATPase and GTPase activities
C6I20_06375	COG1481	regulation of sporulation
C6I20_06380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6I20_06385	COG0126	phosphoglycerate kinase activity
C6I20_06390	COG0149	triose-phosphate isomerase activity
C6I20_06395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6I20_06420	COG0166	Belongs to the GPI family
C6I20_06425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6I20_06435	COG0109	protoheme IX farnesyltransferase activity
C6I20_06460	COG1612	heme a metabolic process
C6I20_06475	COG1793	dna ligase
C6I20_06480	COG2357	RelA SpoT domain protein
C6I20_06515	COG0396	ATPase activity
C6I20_06520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6I20_06525	COG0822	iron-sulfur transferase activity
C6I20_06530	COG2151	metal-sulfur cluster biosynthetic enzyme
C6I20_06535	COG0488	(ABC) transporter
C6I20_06560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6I20_06575	COG3360	Dodecin
C6I20_06585	COG0560	Phosphoserine phosphatase
C6I20_06585	COG3830	Belongs to the UPF0237 family
C6I20_06590	COG1119	ATPase activity
C6I20_06610	COG1881	PFAM PEBP family protein
C6I20_06625	COG0242	peptide deformylase activity
C6I20_06630	COG1960	acyl-CoA dehydrogenase activity
C6I20_06635	COG1960	acyl-CoA dehydrogenase activity
C6I20_06655	COG0545	Peptidyl-prolyl cis-trans isomerase
C6I20_06660	COG1643	Atp-dependent helicase
C6I20_06670	COG2733	membrane
C6I20_06765	COG0328	RNA-DNA hybrid ribonuclease activity
C6I20_06775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_06785	COG2208	phosphoserine phosphatase activity
C6I20_06790	COG0596	Alpha beta hydrolase
C6I20_06820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6I20_06830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_06840	COG0667	Aldo Keto reductase
C6I20_06845	COG1968	undecaprenyl-diphosphatase activity
C6I20_06850	COG0598	Magnesium transport protein CorA
C6I20_06855	COG0215	cysteine-tRNA ligase activity
C6I20_06875	COG0646	methionine synthase
C6I20_06875	COG1410	methionine synthase
C6I20_06880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6I20_06900	COG1222	aaa ATPase
C6I20_06910	COG4122	O-methyltransferase activity
C6I20_06920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_06925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_06930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_06955	COG0805	protein transport
C6I20_06960	COG1597	lipid kinase activity
C6I20_06970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6I20_06990	COG0463	Glycosyl transferase, family 2
C6I20_07000	COG0477	Major facilitator Superfamily
C6I20_07015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6I20_07020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6I20_07055	COG2226	methyltransferase
C6I20_07085	COG0009	L-threonylcarbamoyladenylate synthase
C6I20_07090	COG0175	sulfate reduction
C6I20_07105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6I20_07105	COG1648	precorrin-2 dehydrogenase activity
C6I20_07135	COG1595	DNA-templated transcription, initiation
C6I20_07150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6I20_07150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6I20_07175	COG0509	glycine decarboxylation via glycine cleavage system
C6I20_07200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6I20_07225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6I20_07240	COG2501	S4 domain
C6I20_07250	COG1051	belongs to the nudix hydrolase family
C6I20_07285	COG2066	Belongs to the glutaminase family
C6I20_07295	COG0659	secondary active sulfate transmembrane transporter activity
C6I20_07300	COG0475	glutathione-regulated potassium exporter activity
C6I20_07310	COG1131	(ABC) transporter
C6I20_07325	COG0668	transmembrane transport
C6I20_07370	COG2197	response regulator
C6I20_07385	COG1136	(ABC) transporter
C6I20_07390	COG1595	DNA-templated transcription, initiation
C6I20_07410	COG1309	transcriptional regulator
C6I20_07415	COG2409	Drug exporters of the RND superfamily
C6I20_07420	COG0662	Cupin 2, conserved barrel domain protein
C6I20_07445	COG1140	nitrate reductase beta subunit
C6I20_07460	COG0450	alkyl hydroperoxide reductase
C6I20_07465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_07470	COG2188	Transcriptional regulator
C6I20_07475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_07480	COG0730	response to heat
C6I20_07495	COG0745	RESPONSE REGULATOR receiver
C6I20_07500	COG2205	protein histidine kinase activity
C6I20_07505	COG2132	Multicopper oxidase
C6I20_07535	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_07550	COG1063	alcohol dehydrogenase
C6I20_07560	COG2815	serine threonine protein kinase
C6I20_07560	COG0515	serine threonine protein kinase
C6I20_07575	COG0798	PFAM Bile acid sodium symporter
C6I20_07595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_07630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6I20_07655	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C6I20_07695	COG1160	GTP binding
C6I20_07700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6I20_07730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6I20_07835	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C6I20_07870	COG2197	response regulator
C6I20_07880	COG1960	acyl-CoA dehydrogenase activity
C6I20_07890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6I20_07890	COG0574	Belongs to the PEP-utilizing enzyme family
C6I20_07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6I20_07900	COG1074	ATP-dependent DNA helicase activity
C6I20_07905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6I20_07935	COG1396	sequence-specific DNA binding
C6I20_07960	COG1469	GTP cyclohydrolase I activity
C6I20_07965	COG0720	synthase
C6I20_07970	COG0602	queuosine metabolic process
C6I20_08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_08040	COG2205	protein histidine kinase activity
C6I20_08065	COG2815	serine threonine protein kinase
C6I20_08065	COG0515	serine threonine protein kinase
C6I20_08080	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C6I20_08110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6I20_08115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6I20_08120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6I20_08130	COG2261	transglycosylase associated protein
C6I20_08135	COG0783	Belongs to the Dps family
C6I20_08145	COG4941	Belongs to the sigma-70 factor family
C6I20_08165	COG0519	Catalyzes the synthesis of GMP from XMP
C6I20_08165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6I20_08195	COG1295	ribonuclease BN
C6I20_08210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6I20_08225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6I20_08230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6I20_08235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6I20_08260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6I20_08300	COG1126	abc transporter atp-binding protein
C6I20_08305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6I20_08310	COG0765	amino acid transport
C6I20_08315	COG0765	amino acid transport
C6I20_08340	COG2137	regulation of response to DNA damage stimulus
C6I20_08345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6I20_08355	COG1396	sequence-specific DNA binding
C6I20_08360	COG1546	Belongs to the CinA family
C6I20_08360	COG1058	Belongs to the CinA family
C6I20_08365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6I20_08375	COG1674	ftsk spoiiie
C6I20_08385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C6I20_08390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6I20_08410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6I20_08435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6I20_08440	COG3844	kynureninase activity
C6I20_08450	COG1185	polyribonucleotide nucleotidyltransferase activity
C6I20_08460	COG2755	lipolytic protein G-D-S-L family
C6I20_08470	COG0196	riboflavin kinase activity
C6I20_08475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6I20_08480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6I20_08485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6I20_08490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6I20_08505	COG0779	Required for maturation of 30S ribosomal subunits
C6I20_08520	COG0442	prolyl-tRNA aminoacylation
C6I20_08530	COG0726	polysaccharide deacetylase
C6I20_08580	COG0302	gtp cyclohydrolase
C6I20_08590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6I20_08595	COG0750	zinc metalloprotease
C6I20_08610	COG1131	(ABC) transporter
C6I20_08615	COG4585	Histidine kinase
C6I20_08620	COG2197	response regulator
C6I20_08635	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_08640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6I20_08645	COG1177	transmembrane transport
C6I20_08650	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6I20_08655	COG3842	ATPase activity
C6I20_08665	COG1522	sequence-specific DNA binding
C6I20_08685	COG1160	GTP binding
C6I20_08695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6I20_08710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6I20_08740	COG0504	CTP synthase activity
C6I20_08750	COG0497	DNA recombination
C6I20_08755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6I20_08770	COG0647	UMP catabolic process
C6I20_08800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6I20_08805	COG0589	response to stress
C6I20_08815	COG2824	Alkylphosphonate utilization operon protein PhnA
C6I20_08820	COG2094	Belongs to the DNA glycosylase MPG family
C6I20_08825	COG0165	Argininosuccinate lyase
C6I20_08830	COG1438	arginine binding
C6I20_08835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6I20_08840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6I20_08845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6I20_08850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6I20_08855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6I20_08870	COG1704	LemA family
C6I20_08875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6I20_08875	COG0072	phenylalanine-tRNA ligase activity
C6I20_08880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6I20_08885	COG5002	protein histidine kinase activity
C6I20_08890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6I20_08895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6I20_08900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6I20_08905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6I20_08925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6I20_08930	COG0140	phosphoribosyl-ATP diphosphatase activity
C6I20_08935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6I20_08940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6I20_08940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6I20_08955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6I20_08970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6I20_08980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6I20_08990	COG1758	RNA polymerase activity
C6I20_08995	COG0194	GDP metabolic process
C6I20_09010	COG0284	orotidine-5'-phosphate decarboxylase activity
C6I20_09015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6I20_09020	COG0505	Belongs to the CarA family
C6I20_09025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6I20_09030	COG0540	Belongs to the ATCase OTCase family
C6I20_09035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C6I20_09050	COG0517	IMP dehydrogenase activity
C6I20_09050	COG1125	glycine betaine transport
C6I20_09055	COG1174	glycine betaine transport
C6I20_09065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6I20_09070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6I20_09080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6I20_09085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6I20_09090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6I20_09095	COG2076	Multidrug Resistance protein
C6I20_09105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6I20_09115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6I20_09120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6I20_09140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6I20_09145	COG0124	histidyl-tRNA synthetase
C6I20_09155	COG1196	nuclear chromosome segregation
C6I20_09165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6I20_09170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6I20_09180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_09185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_09195	COG2255	four-way junction helicase activity
C6I20_09200	COG0632	four-way junction helicase activity
C6I20_09205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6I20_09210	COG0217	transcriptional regulatory protein
C6I20_09215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C6I20_09250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C6I20_09260	COG3396	Phenylacetate-CoA oxygenase
C6I20_09275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6I20_09280	COG2201	protein-glutamate methylesterase activity
C6I20_09330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6I20_09365	COG1960	acyl-CoA dehydrogenase activity
C6I20_09390	COG2326	polyphosphate kinase activity
C6I20_09400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6I20_09415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6I20_09430	COG0672	)-iron permease
C6I20_09440	COG0667	Aldo Keto reductase
C6I20_09450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_09495	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6I20_09515	COG0343	queuine tRNA-ribosyltransferase activity
C6I20_09525	COG0644	oxidoreductase
C6I20_09545	COG3300	MHYT domain
C6I20_09545	COG5001	Diguanylate cyclase
C6I20_09560	COG4412	M6 family metalloprotease domain protein
C6I20_09560	COG3291	Pkd domain containing protein
C6I20_09570	COG2133	pyrroloquinoline quinone binding
C6I20_09575	COG2815	serine threonine protein kinase
C6I20_09575	COG0515	serine threonine protein kinase
C6I20_09585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6I20_09600	COG3384	dioxygenase
C6I20_09615	COG2610	gluconate transmembrane transporter activity
C6I20_09625	COG3265	gluconokinase activity
C6I20_09630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_09650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6I20_09665	COG2307	Protein conserved in bacteria
C6I20_09665	COG2308	Evidence 4 Homologs of previously reported genes of
C6I20_09675	COG0233	cytoplasmic translational termination
C6I20_09680	COG0528	UMP kinase activity
C6I20_09685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6I20_09690	COG0052	Belongs to the universal ribosomal protein uS2 family
C6I20_09695	COG1196	nuclear chromosome segregation
C6I20_09695	COG0741	lytic transglycosylase activity
C6I20_09695	COG0739	heme binding
C6I20_09705	COG0758	DNA mediated transformation
C6I20_09710	COG0606	chelatase, subunit chli
C6I20_09715	COG0792	nuclease activity
C6I20_09725	COG1396	sequence-specific DNA binding
C6I20_09725	COG1917	Cupin 2, conserved barrel domain protein
C6I20_09735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6I20_09740	COG0335	large ribosomal subunit rRNA binding
C6I20_09745	COG0336	Belongs to the RNA methyltransferase TrmD family
C6I20_09750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6I20_09755	COG1837	Belongs to the UPF0109 family
C6I20_09760	COG0228	four-way junction DNA binding
C6I20_09775	COG1024	Enoyl-CoA hydratase
C6I20_09785	COG1393	Belongs to the ArsC family
C6I20_09800	COG3265	gluconokinase activity
C6I20_09810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6I20_09855	COG2233	PERMEase
C6I20_09870	COG0423	glycine-tRNA ligase activity
C6I20_09880	COG1121	(ABC) transporter
C6I20_09885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6I20_09905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_09915	COG1027	Aspartate ammonia-lyase
C6I20_09920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6I20_09925	COG0473	3-isopropylmalate dehydrogenase activity
C6I20_09935	COG0531	amino acid
C6I20_09955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6I20_09960	COG0440	acetolactate synthase activity
C6I20_09975	COG0129	dihydroxy-acid dehydratase activity
C6I20_10010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6I20_10020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6I20_10025	COG0154	amidase activity
C6I20_10030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6I20_10045	COG0564	pseudouridine synthase activity
C6I20_10060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6I20_10070	COG0482	sulfurtransferase activity
C6I20_10085	COG1104	cysteine desulfurase activity
C6I20_10095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C6I20_10100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6I20_10110	COG0587	DNA-directed DNA polymerase activity
C6I20_10135	COG0601	transmembrane transport
C6I20_10145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6I20_10150	COG2086	electron transfer activity
C6I20_10185	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6I20_10190	COG3281	Trehalose synthase
C6I20_10195	COG0366	Alpha amylase catalytic
C6I20_10200	COG0366	Alpha amylase catalytic
C6I20_10220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6I20_10230	COG0667	Aldo Keto reductase
C6I20_10285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_10295	COG1278	Cold shock
C6I20_10330	COG0183	Belongs to the thiolase family
C6I20_10365	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_10375	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C6I20_10385	COG1528	Iron-storage protein
C6I20_10415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6I20_10420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6I20_10425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6I20_10430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6I20_10435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6I20_10440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6I20_10445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6I20_10450	COG0356	it plays a direct role in the translocation of protons across the membrane
C6I20_10460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6I20_10475	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_10480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6I20_10485	COG0254	rRNA binding
C6I20_10490	COG0386	Belongs to the glutathione peroxidase family
C6I20_10500	COG0083	homoserine kinase activity
C6I20_10505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6I20_10510	COG0460	homoserine dehydrogenase
C6I20_10520	COG0019	diaminopimelate decarboxylase activity
C6I20_10525	COG0018	arginyl-trna synthetase
C6I20_10540	COG1764	response to oxidative stress
C6I20_10550	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_10550	COG0567	Dehydrogenase, E1 component
C6I20_10555	COG0604	alcohol dehydrogenase
C6I20_10600	COG3842	ATPase activity
C6I20_10625	COG1595	DNA-templated transcription, initiation
C6I20_10630	COG2135	peptidase activity
C6I20_10650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6I20_10660	COG0483	inositol monophosphate 1-phosphatase activity
C6I20_10665	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C6I20_10675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6I20_10700	COG1960	acyl-CoA dehydrogenase activity
C6I20_10715	COG1902	pentaerythritol trinitrate reductase activity
C6I20_10720	COG1252	NADH dehydrogenase
C6I20_10755	COG2301	Belongs to the HpcH HpaI aldolase family
C6I20_10770	COG4129	membrane
C6I20_10810	COG3135	benzoate transporter
C6I20_10815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6I20_10825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6I20_10830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6I20_10835	COG1234	tRNA 3'-trailer cleavage
C6I20_10840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6I20_10845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6I20_10870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6I20_10880	COG1335	isochorismatase
C6I20_10885	COG4552	Acetyltransferase involved in intracellular survival and related
C6I20_10900	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C6I20_10905	COG0145	ligase activity
C6I20_10910	COG4647	ligase activity
C6I20_10915	COG0145	ligase activity
C6I20_10920	COG3284	Transcriptional regulator
C6I20_10930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6I20_10935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6I20_10940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_10970	COG1678	Uncharacterized ACR, COG1678
C6I20_10985	COG1309	transcriptional regulator
C6I20_10990	COG1470	cell adhesion involved in biofilm formation
C6I20_10995	COG1201	RNA secondary structure unwinding
C6I20_11015	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6I20_11020	COG2226	methyltransferase
C6I20_11040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6I20_11055	COG2884	Cell division ATP-binding protein ftsE
C6I20_11060	COG0673	inositol 2-dehydrogenase activity
C6I20_11065	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6I20_11100	COG0515	serine threonine protein kinase
C6I20_11100	COG2815	serine threonine protein kinase
C6I20_11110	COG0475	glutathione-regulated potassium exporter activity
C6I20_11115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6I20_11115	COG0515	serine threonine protein kinase
C6I20_11185	COG2318	DinB family
C6I20_11210	COG0745	RESPONSE REGULATOR receiver
C6I20_11215	COG2205	protein histidine kinase activity
C6I20_11220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6I20_11230	COG1842	Phage shock protein A
C6I20_11280	COG0653	protein targeting
C6I20_11285	COG3214	Protein conserved in bacteria
C6I20_11290	COG2197	response regulator
C6I20_11295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6I20_11300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6I20_11305	COG5401	PFAM Sporulation and spore germination
C6I20_11310	COG5002	protein histidine kinase activity
C6I20_11310	COG5000	phosphorelay sensor kinase activity
C6I20_11315	COG0745	RESPONSE REGULATOR receiver
C6I20_11320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6I20_11340	COG2835	tetraacyldisaccharide 4'-kinase activity
C6I20_11390	COG1388	LysM domain
C6I20_11390	COG1134	teichoic acid transport
C6I20_11395	COG1316	TRANSCRIPTIONal
C6I20_11405	COG1316	TRANSCRIPTIONal
C6I20_11410	COG2171	N-acyltransferase activity
C6I20_11450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_11465	COG0277	FAD linked oxidase domain protein
C6I20_11500	COG0604	alcohol dehydrogenase
C6I20_11515	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_11545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_11595	COG4585	Histidine kinase
C6I20_11600	COG2197	response regulator
C6I20_11605	COG0012	GTP binding
C6I20_11620	COG1322	Protein conserved in bacteria
C6I20_11635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6I20_11640	COG1570	exodeoxyribonuclease VII activity
C6I20_11645	COG1722	exodeoxyribonuclease VII activity
C6I20_11685	COG0114	fumarate hydratase activity
C6I20_11715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6I20_11740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6I20_11750	COG1331	Highly conserved protein containing a thioredoxin domain
C6I20_11755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6I20_11755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6I20_11770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_11775	COG4221	oxidoreductase activity
C6I20_11785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6I20_11790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6I20_11805	COG2315	Protein conserved in bacteria
C6I20_11815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6I20_11820	COG3663	DNA glycosylase
C6I20_11830	COG1309	transcriptional regulator
C6I20_11840	COG1132	(ABC) transporter
C6I20_11865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6I20_11875	COG0746	molybdenum cofactor guanylyltransferase activity
C6I20_11885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6I20_11920	COG0667	Aldo Keto reductase
C6I20_11935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6I20_11955	COG0148	phosphopyruvate hydratase activity
C6I20_12005	COG1316	TRANSCRIPTIONal
C6I20_12025	COG1088	dTDP-glucose 4,6-dehydratase activity
C6I20_12030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6I20_12035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6I20_12040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6I20_12045	COG2244	polysaccharide biosynthetic process
C6I20_12050	COG0438	transferase activity, transferring glycosyl groups
C6I20_12060	COG1215	transferase activity, transferring glycosyl groups
C6I20_12130	COG0193	aminoacyl-tRNA hydrolase activity
C6I20_12135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6I20_12150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6I20_12165	COG1846	Transcriptional regulator
C6I20_12170	COG0488	(ABC) transporter
C6I20_12175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6I20_12180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6I20_12185	COG3583	domain protein
C6I20_12190	COG0084	hydrolase, TatD family'
C6I20_12195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6I20_12225	COG1773	rubredoxin
C6I20_12235	COG3239	Fatty acid desaturase
C6I20_12260	COG2894	cell division
C6I20_12315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_12320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6I20_12330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_12345	COG0745	RESPONSE REGULATOR receiver
C6I20_12350	COG5002	protein histidine kinase activity
C6I20_12360	COG0671	phosphoesterase, PA-phosphatase related
C6I20_12375	COG0586	Pfam SNARE associated Golgi protein
C6I20_12390	COG4325	translation initiation factor activity
C6I20_12405	COG0315	cyclic pyranopterin monophosphate synthase activity
C6I20_12405	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6I20_12410	COG0315	cyclic pyranopterin monophosphate synthase activity
C6I20_12425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6I20_12460	COG1970	mechanosensitive ion channel activity
C6I20_12485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6I20_12505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_12550	COG1088	dTDP-glucose 4,6-dehydratase activity
C6I20_12560	COG0259	pyridoxamine-phosphate oxidase activity
C6I20_12580	COG1305	Transglutaminase-like
C6I20_12605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6I20_12615	COG2252	PERMEase
C6I20_12640	COG2814	Major facilitator Superfamily
C6I20_12645	COG1278	Cold shock
C6I20_12650	COG1295	ribonuclease BN
C6I20_12655	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_12660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6I20_12665	COG1215	transferase activity, transferring glycosyl groups
C6I20_12710	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_12735	COG1131	(ABC) transporter
C6I20_12740	COG3483	tryptophan 2,3-dioxygenase activity
C6I20_12755	COG0459	protein refolding
C6I20_12780	COG1278	Cold shock
C6I20_12785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6I20_12820	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6I20_12830	COG0076	glutamate decarboxylase activity
C6I20_12850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_12860	COG0686	Belongs to the AlaDH PNT family
C6I20_12875	COG0738	Major facilitator superfamily
C6I20_12895	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6I20_12910	COG1960	acyl-CoA dehydrogenase activity
C6I20_12915	COG1309	transcriptional regulator
C6I20_12920	COG2050	protein possibly involved in aromatic compounds catabolism
C6I20_12925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_12930	COG2151	metal-sulfur cluster biosynthetic enzyme
C6I20_12935	COG3396	Phenylacetate-CoA oxygenase
C6I20_12940	COG3460	Phenylacetate-CoA oxygenase
C6I20_12945	COG3396	Phenylacetate-CoA oxygenase
C6I20_12950	COG2030	dehydratase
C6I20_12950	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_12980	COG1522	sequence-specific DNA binding
C6I20_13000	COG0385	Bile acid
C6I20_13025	COG2894	cell division
C6I20_13050	COG3850	Histidine kinase
C6I20_13055	COG2197	response regulator
C6I20_13125	COG0215	cysteine-tRNA ligase activity
C6I20_13140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6I20_13145	COG1329	Transcriptional regulator
C6I20_13170	COG0588	phosphoglycerate mutase activity
C6I20_13180	COG2855	membrane
C6I20_13195	COG0438	transferase activity, transferring glycosyl groups
C6I20_13210	COG0477	Major facilitator Superfamily
C6I20_13215	COG1846	Transcriptional regulator
C6I20_13235	COG3559	Exporter of polyketide antibiotics
C6I20_13240	COG1131	(ABC) transporter
C6I20_13280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6I20_13290	COG0489	protein tyrosine kinase activity
C6I20_13295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6I20_13300	COG0354	folic acid binding
C6I20_13305	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C6I20_13310	COG1490	D-aminoacyl-tRNA deacylase activity
C6I20_13360	COG0745	RESPONSE REGULATOR receiver
C6I20_13370	COG0456	acetyltransferase
C6I20_13380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6I20_13395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6I20_13410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6I20_13415	COG0306	phosphate transporter
C6I20_13450	COG0387	Pfam Sodium calcium exchanger
C6I20_13465	COG0596	Alpha beta hydrolase
C6I20_13510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_13520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6I20_13545	COG0390	transport system, permease component
C6I20_13555	COG0456	acetyltransferase
C6I20_13560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6I20_13575	COG2409	Drug exporters of the RND superfamily
C6I20_13590	COG1174	glycine betaine transport
C6I20_13615	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_13645	COG2267	carboxylic ester hydrolase activity
C6I20_13650	COG2267	carboxylic ester hydrolase activity
C6I20_13680	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_13690	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_13695	COG1129	ABC transporter
C6I20_13710	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_13715	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_13730	COG1960	acyl-CoA dehydrogenase activity
C6I20_13745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6I20_13760	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_13775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6I20_13780	COG1902	pentaerythritol trinitrate reductase activity
C6I20_13810	COG1309	transcriptional regulator
C6I20_13825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6I20_13850	COG0513	Belongs to the DEAD box helicase family
C6I20_13865	COG0047	phosphoribosylformylglycinamidine synthase activity
C6I20_13870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6I20_13875	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_13895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6I20_13905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6I20_13910	COG0151	Belongs to the GarS family
C6I20_13915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6I20_13960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6I20_13965	COG3764	Sortase (surface protein transpeptidase)
C6I20_13985	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6I20_14015	COG0287	Prephenate dehydrogenase
C6I20_14015	COG1605	Chorismate mutase
C6I20_14030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6I20_14045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6I20_14045	COG1754	DNA topoisomerase type I activity
C6I20_14055	COG1247	-acetyltransferase
C6I20_14070	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_14075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C6I20_14080	COG1366	Belongs to the anti-sigma-factor antagonist family
C6I20_14085	COG1205	dead DEAH box helicase
C6I20_14085	COG1111	helicase
C6I20_14145	COG0110	maltose O-acetyltransferase activity
C6I20_14155	COG2226	methyltransferase
C6I20_14175	COG0489	protein tyrosine kinase activity
C6I20_14180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6I20_14195	COG2755	lipolytic protein G-D-S-L family
C6I20_14215	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_14250	COG1268	BioY protein
C6I20_14255	COG1122	ATPase activity
C6I20_14265	COG3275	phosphorelay sensor kinase activity
C6I20_14280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6I20_14290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6I20_14295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_14315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_14325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6I20_14340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_14375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6I20_14385	COG1408	metallophosphoesterase
C6I20_14420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6I20_14465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_14485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6I20_14500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6I20_14520	COG1960	acyl-CoA dehydrogenase activity
C6I20_14525	COG1960	acyl-CoA dehydrogenase activity
C6I20_14550	COG1609	Transcriptional regulator
C6I20_14560	COG1175	transmembrane transport
C6I20_14565	COG0395	ABC-type sugar transport system, permease component
C6I20_14575	COG3842	ATPase activity
C6I20_14585	COG0596	Alpha beta hydrolase
C6I20_14590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6I20_14595	COG4134	Bacterial extracellular solute-binding protein
C6I20_14610	COG3842	ATPase activity
C6I20_14640	COG2045	Belongs to the ComB family
C6I20_14650	COG0433	COG0433 Predicted ATPase
C6I20_14665	COG3263	regulation of cellular component size
C6I20_14680	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_14695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6I20_14735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6I20_14740	COG0659	secondary active sulfate transmembrane transporter activity
C6I20_14745	COG0789	Transcriptional regulator
C6I20_14780	COG1072	(Pantothenic acid kinase))
C6I20_14790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_14800	COG0590	tRNA wobble adenosine to inosine editing
C6I20_14805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6I20_14810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C6I20_14815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C6I20_14820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6I20_14825	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_14840	COG0583	DNA-binding transcription factor activity
C6I20_14855	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_14860	COG1177	transmembrane transport
C6I20_14865	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6I20_14870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6I20_14875	COG3842	ATPase activity
C6I20_14900	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_14905	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6I20_14940	COG0681	Belongs to the peptidase S26 family
C6I20_14950	COG0038	chloride channel
C6I20_14955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6I20_14960	COG0738	Major facilitator superfamily
C6I20_14975	COG1335	isochorismatase
C6I20_14980	COG1802	Transcriptional regulator
C6I20_14985	COG0277	FAD linked oxidase domain protein
C6I20_15015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6I20_15020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6I20_15075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6I20_15090	COG0604	alcohol dehydrogenase
C6I20_15105	COG0561	phosphatase activity
C6I20_15110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6I20_15120	COG0596	Alpha beta hydrolase
C6I20_15125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_15150	COG2235	arginine
C6I20_15175	COG0776	regulation of translation
C6I20_15180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6I20_15195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_15205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_15210	COG1309	transcriptional regulator
C6I20_15220	COG0583	DNA-binding transcription factor activity
C6I20_15225	COG0477	Major facilitator Superfamily
C6I20_15270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6I20_15290	COG1716	ATPase activity
C6I20_15295	COG1716	ATPase activity
C6I20_15310	COG0768	penicillin binding
C6I20_15315	COG0515	serine threonine protein kinase
C6I20_15330	COG0705	Rhomboid family
C6I20_15350	COG1024	Enoyl-CoA hydratase
C6I20_15365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6I20_15370	COG4166	transmembrane transport
C6I20_15375	COG0601	transmembrane transport
C6I20_15385	COG2755	lipolytic protein G-D-S-L family
C6I20_15390	COG2318	DinB family
C6I20_15420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_15445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6I20_15450	COG0187	DNA topoisomerase II activity
C6I20_15460	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C6I20_15465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6I20_15470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6I20_15475	COG0592	DNA-directed DNA polymerase activity
C6I20_15480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6I20_15490	COG0594	ribonuclease P activity
C6I20_15495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6I20_15500	COG0706	membrane insertase activity
C6I20_15510	COG0357	Ribosomal RNA small subunit methyltransferase G
C6I20_15515	COG1192	Involved in chromosome partitioning
C6I20_15525	COG1879	ABC-type sugar transport system periplasmic component
C6I20_15530	COG1129	ABC transporter
C6I20_15535	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_15540	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_15550	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_15555	COG3118	belongs to the thioredoxin family
C6I20_15565	COG2815	serine threonine protein kinase
C6I20_15565	COG0515	serine threonine protein kinase
C6I20_15580	COG0617	tRNA 3'-terminal CCA addition
C6I20_15595	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6I20_15600	COG1022	Amp-dependent synthetase and ligase
C6I20_15610	COG0410	ABC transporter
C6I20_15630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6I20_15640	COG2348	transferase activity, transferring amino-acyl groups
C6I20_15660	COG1305	Transglutaminase-like
C6I20_15670	COG0667	Aldo Keto reductase
C6I20_15680	COG0577	efflux transmembrane transporter activity
C6I20_15680	COG1136	(ABC) transporter
C6I20_15685	COG0577	efflux transmembrane transporter activity
C6I20_15685	COG1136	(ABC) transporter
C6I20_15690	COG0360	Binds together with S18 to 16S ribosomal RNA
C6I20_15695	COG0629	single-stranded DNA binding
C6I20_15700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6I20_15705	COG0359	binds to the 23S rRNA
C6I20_15725	COG0305	Participates in initiation and elongation during chromosome replication
C6I20_15735	COG0586	Pfam SNARE associated Golgi protein
C6I20_15750	COG1132	(ABC) transporter
C6I20_15755	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C6I20_15765	COG1937	Protein conserved in bacteria
C6I20_15795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6I20_15815	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6I20_15815	COG1902	pentaerythritol trinitrate reductase activity
C6I20_15850	COG0640	Transcriptional regulator
C6I20_15870	COG2197	response regulator
C6I20_15890	COG0633	Ferredoxin
C6I20_15950	COG1119	ATPase activity
C6I20_15960	COG0596	Alpha beta hydrolase
C6I20_15965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6I20_15990	COG0183	Belongs to the thiolase family
C6I20_15995	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_15995	COG1024	Enoyl-CoA hydratase
C6I20_16035	COG0702	epimerase
C6I20_16055	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_16075	COG1024	Enoyl-CoA hydratase
C6I20_16110	COG0300	oxidoreductase activity
C6I20_16140	COG2072	flavoprotein involved in K transport
C6I20_16145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6I20_16150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6I20_16165	COG2072	flavoprotein involved in K transport
C6I20_16170	COG1131	(ABC) transporter
C6I20_16185	COG4585	Histidine kinase
C6I20_16190	COG2197	response regulator
C6I20_16200	COG0657	acetylesterase activity
C6I20_16225	COG1960	acyl-CoA dehydrogenase activity
C6I20_16230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_16250	COG0765	amino acid transport
C6I20_16255	COG1126	abc transporter atp-binding protein
C6I20_16270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_16315	COG0697	spore germination
C6I20_16320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_16325	COG2205	protein histidine kinase activity
C6I20_16330	COG0745	RESPONSE REGULATOR receiver
C6I20_16345	COG1950	PFAM Membrane protein of
C6I20_16350	COG0697	spore germination
C6I20_16355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6I20_16365	COG0022	dehydrogenase e1 component
C6I20_16370	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_16405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6I20_16410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6I20_16440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C6I20_16445	COG4988	ABC transporter
C6I20_16450	COG1294	oxidase, subunit
C6I20_16455	COG1271	oxidase subunit
C6I20_16470	COG1846	Transcriptional regulator
C6I20_16475	COG1960	acyl-CoA dehydrogenase activity
C6I20_16495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6I20_16500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6I20_16505	COG5002	protein histidine kinase activity
C6I20_16510	COG0745	RESPONSE REGULATOR receiver
C6I20_16555	COG1063	alcohol dehydrogenase
C6I20_16560	COG0579	oxidoreductase
C6I20_16570	COG1024	Enoyl-CoA hydratase
C6I20_16570	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_16575	COG0717	Belongs to the dCTP deaminase family
C6I20_16580	COG2313	pseudouridylate synthase activity
C6I20_16585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_16595	COG2942	2-epimerase
C6I20_16625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6I20_16640	COG1228	amidohydrolase
C6I20_16645	COG3012	SEC-C Motif Domain Protein
C6I20_16650	COG0247	lactate metabolic process
C6I20_16650	COG2181	nitrate reductase activity
C6I20_16655	COG2271	Major facilitator Superfamily
C6I20_16670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_16705	COG1122	ATPase activity
C6I20_16750	COG0154	amidase activity
C6I20_16760	COG1309	transcriptional regulator
C6I20_16770	COG2271	Major facilitator Superfamily
C6I20_16780	COG2409	Drug exporters of the RND superfamily
C6I20_16795	COG0443	Heat shock 70 kDa protein
C6I20_16800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6I20_16805	COG0484	heat shock protein binding
C6I20_16810	COG0789	Transcriptional regulator
C6I20_16830	COG0463	Glycosyl transferase, family 2
C6I20_16840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6I20_16855	COG1902	pentaerythritol trinitrate reductase activity
C6I20_16880	COG0318	PFAM AMP-dependent synthetase and ligase