locus-tag class description GEV26_00235 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GEV26_00240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GEV26_00245 ENOG4108J5G 6-phosphogluconate dehydrogenase GEV26_00250 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GEV26_00255 ENOG4105K7N UPF0232 protein GEV26_00265 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GEV26_00270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GEV26_00330 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GEV26_00335 ENOG4108J59 Extracellular solute-binding protein, family 5 GEV26_00350 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GEV26_00365 ENOG4105E39 Enoyl-CoA hydratase GEV26_00370 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) GEV26_00380 ENOG4105ZJT Cell division protein CrgA GEV26_00395 ENOG4105CJN penicillin-binding protein GEV26_00410 ENOG4105HZM Fha domain containing protein GEV26_00415 ENOG4105TV9 FHA Domain-Containing protein GEV26_00435 ENOG4107QNK )-transporter GEV26_00445 ENOG4105CHR reductase GEV26_00470 ENOG4107R7Y intracellular protease Pfpi family GEV26_00475 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GEV26_00500 ENOG4105C57 major facilitator superfamily GEV26_00505 ENOG4108594 Permease of the drug metabolite transporter GEV26_00515 ENOG4107QX3 carboxylase GEV26_00525 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GEV26_00540 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GEV26_00545 ENOG4108426 dNA-binding protein GEV26_00555 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GEV26_00570 ENOG4105CEU Arginine dihydrolase GEV26_00600 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GEV26_00615 ENOG4107TE5 Lipid kinase GEV26_00620 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GEV26_00625 ENOG410667J hydrolase GEV26_00630 ENOG4105KVH Transcriptional regulator GEV26_00635 ENOG4107S5I aldo keto reductase GEV26_00640 ENOG4107ZED Uncharacterised protein family UPF0047 GEV26_00660 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GEV26_00685 ENOG4105KDM Diguanylate cyclase with gaf sensor GEV26_00715 ENOG4108QV3 biosynthesis protein GEV26_00725 ENOG4105C1B dTDP-glucose 4-6-dehydratase GEV26_00750 ENOG4105C0R drug resistance transporter emrb qaca subfamily GEV26_00835 ENOG4108M8W Monooxygenase GEV26_00840 ENOG4105VC4 domain protein GEV26_00850 ENOG4105DRR Transcriptional regulator, GntR family GEV26_00860 ENOG4105C1G acyl-Coa dehydrogenase GEV26_00865 ENOG4108PGP mmge prpd family protein GEV26_00870 ENOG4105CD5 CoA-binding domain protein GEV26_00875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GEV26_00895 ENOG4105CHU acetyl-coa acetyltransferase GEV26_00900 ENOG4108M9J MaoC like domain protein GEV26_00910 ENOG4105CI0 Citrate lyase GEV26_00915 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F GEV26_00920 ENOG4105CGU Enoyl-CoA hydratase GEV26_00930 ENOG4105CWX Alpha-1,2-mannosidase GEV26_00935 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GEV26_00940 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GEV26_00965 ENOG4105WN5 stage II sporulation protein GEV26_00970 ENOG4105BZU Histidine kinase GEV26_01015 ENOG4105FDF Could be involved in DNA repair (By similarity) GEV26_01020 ENOG4105EQK -acetyltransferase GEV26_01025 ENOG4105C26 Dehydrogenase GEV26_01040 ENOG4105DND Transcriptional regulator GEV26_01050 ENOG4105EYF MMPL domain protein GEV26_01075 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GEV26_01080 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GEV26_01085 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GEV26_01095 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GEV26_01105 ENOG4105DEN Luciferase family GEV26_01115 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GEV26_01125 ENOG4105CS9 pantothenic acid kinase GEV26_01135 ENOG4105C26 Dehydrogenase GEV26_01145 ENOG4108RZE Tetr family transcriptional regulator GEV26_01155 ENOG4105DEF Extracellular solute-binding protein, family 5 GEV26_01165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GEV26_01170 ENOG4105C3U ABC transporter GEV26_01225 ENOG4105CPC Aldo Keto reductase GEV26_01240 ENOG4107S5I aldo keto reductase GEV26_01265 ENOG4105C87 Aminotransferase class I and II GEV26_01270 ENOG4105BZU Histidine kinase GEV26_01290 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GEV26_01305 ENOG4105D7A ATP-binding protein GEV26_01340 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GEV26_01435 ENOG4105X7H acyl-CoA dehydrogenase GEV26_01470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GEV26_01475 ENOG4105CFH Aspartokinase GEV26_01485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GEV26_01500 ENOG4105DIN metallophosphoesterase GEV26_01510 ENOG4105BZ4 penicillin-binding protein GEV26_01515 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GEV26_01545 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GEV26_01565 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GEV26_01570 ENOG4105P8F nudix hydrolase GEV26_01595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GEV26_01605 ENOG4107QN1 sodium solute GEV26_01625 ENOG4108NEV two component transcriptional regulator, LytTR family GEV26_01630 ENOG4108HRK Histidine kinase GEV26_01635 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GEV26_01640 ENOG4108JJB ABC transporter GEV26_01645 ENOG4105VKD bioY protein GEV26_01715 ENOG4108I5C dEAD DEAH box helicase GEV26_01720 ENOG4105WN5 stage II sporulation protein GEV26_01725 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GEV26_01730 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GEV26_01745 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GEV26_01760 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GEV26_01775 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GEV26_01795 ENOG4107R13 MMPL domain protein GEV26_01815 ENOG4107TPY serine threonine protein kinase GEV26_01825 ENOG4106UW1 Major Facilitator superfamily GEV26_01830 ENOG4108U4N (sortase) family GEV26_01835 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GEV26_01850 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GEV26_01870 ENOG4107TE5 Lipid kinase GEV26_01885 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GEV26_01890 ENOG4105C12 Phosphoribosylglycinamide synthetase GEV26_01895 ENOG4105C83 adenylosuccinate lyase GEV26_01905 ENOG4105C8V SAICAR synthetase GEV26_01910 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_01920 ENOG410839H phosphoribosylformylglycinamidine synthase GEV26_01925 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GEV26_01975 ENOG4105EXC Acyl-transferase GEV26_01990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GEV26_01995 ENOG4107QIK phosphoribosylformylglycinamidine synthase GEV26_02030 ENOG4105CXB phosphoribosylaminoimidazole synthetase GEV26_02055 ENOG4105K56 Transcriptional regulator GEV26_02060 ENOG4105PDP Short chain dehydrogenase GEV26_02065 ENOG4108R86 Transcriptional regulator GEV26_02085 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GEV26_02110 ENOG4108IJ8 ABC transporter GEV26_02115 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GEV26_02120 ENOG4105R40 Glycine betaine carnitine choline GEV26_02140 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_02145 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GEV26_02150 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GEV26_02175 ENOG4107E6A Cytochrome p-450 GEV26_02215 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GEV26_02225 ENOG4105EMU Dehydrogenase GEV26_02235 ENOG4107U9T Pfam:Ribonuclease_BN GEV26_02240 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GEV26_02255 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GEV26_02260 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GEV26_02305 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GEV26_02315 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GEV26_02320 ENOG41090RK glycosyl transferase GEV26_02325 ENOG4105K64 Glycosyl transferase, family 2 GEV26_02330 ENOG4107QQG Dehydrogenase GEV26_02335 ENOG4105EXC Acyl-transferase GEV26_02340 ENOG4105EXC Acyl-transferase GEV26_02375 ENOG4105CUB amino acid GEV26_02385 ENOG41073TP transcriptional regulator GEV26_02395 ENOG4105C26 Dehydrogenase GEV26_02400 ENOG4105CHR reductase GEV26_02405 ENOG4108Z86 Glutamine amidotransferase GEV26_02420 ENOG4105D74 hydrolase GEV26_02435 ENOG4105MHT Transcriptional regulator, ARSR family GEV26_02445 ENOG4105BZU Histidine kinase GEV26_02460 ENOG4107TB5 TRANSCRIPTIONal GEV26_02470 ENOG4105C2J ABC transporter GEV26_02485 ENOG4105CNN ABC, transporter GEV26_02495 ENOG4105D2B acyl-CoA dehydrogenase GEV26_02500 ENOG4105DTI Phosphonopyruvate decarboxylase GEV26_02555 ENOG4105CBC glutamate synthase GEV26_02560 ENOG4108TAG Histidine kinase GEV26_02565 ENOG4105ETX regulatoR GEV26_02595 ENOG4105BZU Histidine kinase GEV26_02610 ENOG4105CJ3 phosphate transporter GEV26_02615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GEV26_02630 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GEV26_02645 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GEV26_02655 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GEV26_02665 ENOG4107NHD transcriptional regulator GEV26_02690 ENOG4105KHC sulfurtransferase GEV26_02695 ENOG4105PKJ carbohydrate binding GEV26_02700 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GEV26_02705 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GEV26_02710 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GEV26_02725 ENOG4105EIP mannose-6-phosphate isomerase GEV26_02730 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GEV26_02770 ENOG4105C94 Transporter GEV26_02795 ENOG4105CI3 gtp-binding protein typa GEV26_02800 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GEV26_02805 ENOG4105C0R drug resistance transporter emrb qaca subfamily GEV26_02815 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GEV26_02830 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GEV26_02860 ENOG4108VJ1 Transcriptional regulator (CarD family GEV26_02865 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GEV26_02880 ENOG4105C8N cysteinyl-tRNA synthetase GEV26_02905 ENOG4105XDV GEV26_02930 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GEV26_02940 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GEV26_02950 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GEV26_02955 ENOG4105GVF (ABC) transporter GEV26_02960 ENOG4105E2Y ABC, transporter GEV26_02965 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GEV26_03000 ENOG4105BZU Histidine kinase GEV26_03005 ENOG4105DY8 decarboxylase GEV26_03035 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GEV26_03040 ENOG4105C02 permease GEV26_03045 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GEV26_03050 ENOG4106UW1 Major Facilitator superfamily GEV26_03060 ENOG4105DCF alanine dehydrogenase GEV26_03085 ENOG4105CVK Glutamate decarboxylase GEV26_03095 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GEV26_03130 ENOG4105VEQ Cold shock protein GEV26_03160 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GEV26_03165 ENOG4108IJ6 ABC transporter GEV26_03170 ENOG4105ECW sulfate abc transporter GEV26_03175 ENOG4108I5D sulfate abc transporter GEV26_03180 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GEV26_03200 ENOG4105D9U N-acetyltransferase GEV26_03205 ENOG4105CQC Prephenate dehydratase GEV26_03210 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GEV26_03215 ENOG4105C31 Tryptophanyl-tRNA synthetase GEV26_03225 ENOG4105CMU LysR family (Transcriptional regulator GEV26_03240 ENOG4105E33 succinate dehydrogenase GEV26_03260 ENOG4107RM1 amidohydrolase GEV26_03265 ENOG4105DIH basic membrane GEV26_03270 ENOG4108JQ9 ABC transporter GEV26_03275 ENOG4105UIB (ABC) transporter GEV26_03305 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GEV26_03310 ENOG4105CHU acetyl-coa acetyltransferase GEV26_03320 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GEV26_03330 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GEV26_03335 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GEV26_03340 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GEV26_03355 ENOG4105CGH 5'-nucleotidase GEV26_03370 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GEV26_03375 ENOG4105E9Z Nad-dependent epimerase dehydratase GEV26_03405 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GEV26_03410 ENOG4105EHG Permease protein GEV26_03445 ENOG4108JIK carboxylase GEV26_03450 ENOG4105C1G acyl-Coa dehydrogenase GEV26_03460 ENOG4108QVN serine threonine protein kinase GEV26_03480 ENOG4107WR6 Maf-like protein GEV26_03500 ENOG4105D8K carboxyl transferase GEV26_03515 ENOG4108QER Adenylate cyclase GEV26_03550 ENOG4107R4C succinyl-diaminopimelate desuccinylase GEV26_03555 ENOG4108URH decarboxylase GEV26_03560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GEV26_03575 ENOG4108UKI Enoyl-CoA hydratase GEV26_03590 ENOG4107ZBN O-methyltransferase GEV26_03605 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GEV26_03615 ENOG4105C5H ABC transporter GEV26_03620 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GEV26_03630 ENOG4105CJW magnesium transporter GEV26_03675 ENOG4105C1G acyl-Coa dehydrogenase GEV26_03685 ENOG4105DJG MaoC domain protein dehydratase GEV26_03700 ENOG4105DB7 PHP domain protein GEV26_03710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GEV26_03725 ENOG4105EMU Dehydrogenase GEV26_03740 ENOG4105C1J atp-dependent rna helicase GEV26_03775 ENOG4105C4R Atp-dependent dna helicase GEV26_03795 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GEV26_03825 ENOG41063PX domain protein GEV26_03835 ENOG4105DJZ UPF0182 protein GEV26_03865 ENOG4105EWK phytoene GEV26_03905 ENOG4105CUB amino acid GEV26_03925 ENOG4105D82 Glutamate dehydrogenase GEV26_03940 ENOG4105C26 Dehydrogenase GEV26_03945 ENOG4108JPW Aminotransferase GEV26_03950 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GEV26_03960 ENOG4105C26 Dehydrogenase GEV26_03965 ENOG4105CJP fad dependent oxidoreductase GEV26_03970 ENOG4105CT3 Monooxygenase GEV26_03975 ENOG41076PI Short-chain dehydrogenase reductase Sdr GEV26_03980 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GEV26_03985 ENOG4105C26 Dehydrogenase GEV26_03990 ENOG4105C26 Dehydrogenase GEV26_04005 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GEV26_04010 ENOG4105C1G acyl-Coa dehydrogenase GEV26_04015 ENOG4105FDP GntR family transcriptional regulator GEV26_04030 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GEV26_04040 ENOG4107QN2 dihydrolipoyl dehydrogenase GEV26_04065 ENOG4105BZU Histidine kinase GEV26_04120 ENOG4107HP6 Transcriptional regulator GEV26_04125 ENOG4107QNJ CoA-transferase subunit B GEV26_04135 ENOG4105CHU acetyl-coa acetyltransferase GEV26_04155 ENOG410834F Transcriptional regulator GEV26_04160 ENOG4105EYF MMPL domain protein GEV26_04175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GEV26_04180 ENOG4105C3U ABC transporter GEV26_04205 ENOG4105DTQ mandelate racemase muconate lactonizing GEV26_04220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GEV26_04230 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_04240 ENOG4108YXU transcriptional regulator AsnC family GEV26_04255 ENOG4105CND Glycosyl transferase, family 2 GEV26_04265 ENOG4105BZU Histidine kinase GEV26_04270 ENOG4107W19 lmbE family GEV26_04275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GEV26_04310 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GEV26_04330 ENOG4105CJP fad dependent oxidoreductase GEV26_04345 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GEV26_04360 ENOG4105D9P serine threonine protein kinase GEV26_04370 ENOG4105JAB phenazine biosynthesis protein, phzf family GEV26_04380 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GEV26_04410 ENOG4105NTW Transcriptional regulator GEV26_04415 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GEV26_04420 ENOG4107TK4 histidinol-phosphate phosphatase GEV26_04430 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GEV26_04440 ENOG4108RAV Conserved protein GEV26_04445 ENOG4105EMN RNA polymerase sigma factor GEV26_04480 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GEV26_04500 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GEV26_04505 ENOG4105CNN ABC, transporter GEV26_04510 ENOG4105C2J ABC transporter GEV26_04515 ENOG4105E2R ROK family GEV26_04520 ENOG4105CAK Cell division ATP-binding protein ftsE GEV26_04525 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) GEV26_04540 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GEV26_04560 ENOG4105KZX Pterin carbinolamine dehydratase GEV26_04570 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GEV26_04575 ENOG4107QRT dEAD DEAH box helicase GEV26_04590 ENOG4108R5T secreted protein GEV26_04595 ENOG4108Q5F Tetr family transcriptional regulator GEV26_04610 ENOG4108UJU UPF0301 protein GEV26_04650 ENOG4105HHS UPF0256 protein GEV26_04655 ENOG4108RWI nicotinamidase GEV26_04665 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GEV26_04695 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GEV26_04700 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GEV26_04710 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GEV26_04715 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GEV26_04725 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GEV26_04730 ENOG4105DKK Benzoate GEV26_04765 ENOG41085FC arsR family transcriptional regulator GEV26_04785 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GEV26_04795 ENOG4105G6Z alkaline phosphatase GEV26_04805 ENOG4105CI0 Citrate lyase GEV26_04810 ENOG4105CI0 Citrate lyase GEV26_04855 ENOG4105EUB pirin domain protein GEV26_04860 ENOG4105GCF PGAM GEV26_04865 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GEV26_04875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GEV26_04890 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GEV26_04900 ENOG41083TI Protein CrcB homolog GEV26_04905 ENOG4107JBM CrcB-like protein GEV26_04920 ENOG4105W0E 50S ribosomal protein L33 GEV26_04950 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GEV26_04975 ENOG4108YYC ycei family GEV26_04985 ENOG4105C1G acyl-Coa dehydrogenase GEV26_04990 ENOG4105CHU acetyl-coa acetyltransferase GEV26_04995 ENOG4105CHR reductase GEV26_05000 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GEV26_05005 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GEV26_05035 ENOG4105D8K carboxyl transferase GEV26_05040 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GEV26_05050 ENOG4108Z18 K06886 hemoglobin GEV26_05055 ENOG4105D8X mechanosensitive ion channel GEV26_05070 ENOG4105C1G acyl-Coa dehydrogenase GEV26_05080 ENOG4105C3Q Glycosyl transferase, family 2 GEV26_05095 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) GEV26_05100 ENOG4105MC2 DSBA oxidoreductase GEV26_05145 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GEV26_05165 ENOG4105FDP GntR family transcriptional regulator GEV26_05175 ENOG4105EDK PfkB domain protein GEV26_05185 ENOG4105DH8 myo-inositol catabolism GEV26_05190 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GEV26_05195 ENOG4105C26 Dehydrogenase GEV26_05205 ENOG41062B0 ABC transporter, permease GEV26_05210 ENOG4105C2J ABC transporter GEV26_05215 ENOG4106448 streptomycin biosynthesis protein strI GEV26_05220 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GEV26_05230 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GEV26_05235 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GEV26_05250 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GEV26_05255 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GEV26_05260 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GEV26_05265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GEV26_05270 ENOG4105EG6 Saccharopine dehydrogenase GEV26_05285 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GEV26_05290 ENOG4105EYF MMPL domain protein GEV26_05295 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GEV26_05335 ENOG4105CG3 alpha amylase, catalytic region GEV26_05340 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GEV26_05360 ENOG4107RZX Teichoic acid biosynthesis protein GEV26_05370 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GEV26_05395 ENOG4105DJ2 Major Facilitator Superfamily GEV26_05405 ENOG4105C03 ribonuclease GEV26_05410 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GEV26_05415 ENOG4105K46 50S ribosomal protein l27 GEV26_05420 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GEV26_05425 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GEV26_05430 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GEV26_05435 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GEV26_05445 ENOG4105CVJ phosphoglycerate mutase GEV26_05485 ENOG4108HH4 Major Facilitator Superfamily GEV26_05490 ENOG4105C9K Endothelin-converting enzyme 1 GEV26_05530 ENOG4108MKI Glycosyl transferase, family 2 GEV26_05540 ENOG4105CZN Potassium uptake protein GEV26_05545 ENOG4107ZYR domain protein GEV26_05555 ENOG4105D4Y metalloprotease GEV26_05570 ENOG4105C8T Leucyl-tRNA synthetase GEV26_05575 ENOG4105EPR degv family GEV26_05580 ENOG4105KQC Competence protein GEV26_05595 ENOG4105EYH Exonuclease GEV26_05610 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GEV26_05615 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GEV26_05625 ENOG4108IQE Amp-dependent synthetase and ligase GEV26_05645 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GEV26_05650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GEV26_05655 ENOG4107YU2 histidine triad (hIT) protein GEV26_05665 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GEV26_05680 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GEV26_05690 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GEV26_05715 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GEV26_05730 ENOG4105CHF Glutathione S-transferase GEV26_05740 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GEV26_05755 ENOG4105C26 Dehydrogenase GEV26_05775 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GEV26_05780 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GEV26_05815 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GEV26_05820 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GEV26_05840 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GEV26_05860 ENOG4105CI0 Citrate lyase GEV26_05865 ENOG4108FUF Transcriptional regulator, IclR family GEV26_05870 ENOG4105CP9 extracellular ligand-binding receptor GEV26_05875 ENOG4105C32 Amino acid ABC transporter (Permease) GEV26_05880 ENOG4105C32 Amino acid ABC transporter (Permease) GEV26_05885 ENOG4105C0Z ABC transporter GEV26_05890 ENOG4108IV0 ABC, transporter GEV26_05895 ENOG4105NN7 muconolactone delta-isomerase GEV26_05930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GEV26_05945 ENOG41069M3 Transcriptional regulator GEV26_05950 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GEV26_05955 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GEV26_05970 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GEV26_05975 ENOG4105C28 cystathionine GEV26_05980 ENOG4105CPF Cell wall formation (By similarity) GEV26_06005 ENOG4105VB9 50S ribosomal protein l28 GEV26_06010 ENOG4105DP4 dak2 domain fusion protein ylov GEV26_06020 ENOG4106H78 methyltransferase GEV26_06025 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GEV26_06030 ENOG4108KPJ rna polymerase sigma factor GEV26_06040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GEV26_06050 ENOG41084BZ 50S ribosomal protein L32 GEV26_06055 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GEV26_06060 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GEV26_06070 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GEV26_06080 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GEV26_06095 ENOG4107W19 lmbE family GEV26_06125 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GEV26_06140 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GEV26_06180 ENOG4105C7K acetolactate synthase GEV26_06195 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GEV26_06205 ENOG4105C9U ATP-dependent DNA helicase RecQ GEV26_06210 ENOG4105CPC Aldo Keto reductase GEV26_06215 ENOG4105EGD dinuclear metal center protein, YbgI family GEV26_06225 ENOG4105CVJ phosphoglycerate mutase GEV26_06230 ENOG4107XFJ UPF0246 protein GEV26_06275 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GEV26_06280 ENOG4105C4K Nad synthetase GEV26_06290 ENOG4105CHP RNA polymerase GEV26_06300 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GEV26_06310 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GEV26_06315 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GEV26_06345 ENOG4105EJ2 Transcriptional regulator GEV26_06385 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GEV26_06400 ENOG41090WU lipolytic protein G-D-S-L family GEV26_06405 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GEV26_06410 ENOG4107UNS conserved inner membrane protein GEV26_06415 ENOG4107QTZ amino acid GEV26_06425 ENOG4105VPX protein, conserved in bacteria GEV26_06430 ENOG4108IND Tetr family transcriptional regulator GEV26_06445 ENOG4108UZX fmn reductase GEV26_06460 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GEV26_06470 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GEV26_06475 ENOG4105D3W isochorismatase GEV26_06495 ENOG4105CPU Monooxygenase GEV26_06500 ENOG4105EYF MMPL domain protein GEV26_06505 ENOG4105BZU Histidine kinase GEV26_06510 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_06515 ENOG4105KVH Transcriptional regulator GEV26_06535 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GEV26_06555 ENOG4105C5F glutamine synthetase GEV26_06570 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GEV26_06575 ENOG4105BZU Histidine kinase GEV26_06580 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_06585 ENOG4108IUX (ABC) transporter GEV26_06595 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GEV26_06635 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GEV26_06640 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GEV26_06660 ENOG4105D0M Protease HtpX homolog GEV26_06690 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GEV26_06695 ENOG4105BZ9 Cytochrome C oxidase, subunit I GEV26_06700 ENOG4105MCD Part of cytochrome c oxidase, its function is GEV26_06710 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GEV26_06715 ENOG4107EUI c reductase, iron-sulfur GEV26_06720 ENOG4107UDY cytochrome C GEV26_06725 ENOG4105CCU oxidase (Subunit III) GEV26_06735 ENOG4107S1N anthranilate phosphoribosyltransferase GEV26_06755 ENOG4105ZXU NLP P60 protein GEV26_06765 ENOG4108IQE Amp-dependent synthetase and ligase GEV26_06780 ENOG4105DKQ ROK family GEV26_06785 ENOG4105DKQ ROK family GEV26_06805 ENOG4105CTQ phosphohexokinase GEV26_06815 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GEV26_06840 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GEV26_06850 ENOG4108V6E Cell division protein mraZ GEV26_06855 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GEV26_06865 ENOG4105CJN penicillin-binding protein GEV26_06870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GEV26_06880 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GEV26_06885 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GEV26_06895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GEV26_06900 ENOG4105DFU Cell wall formation (By similarity) GEV26_06915 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GEV26_06920 ENOG4105DFA alanine racemase domain protein GEV26_06925 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GEV26_06940 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GEV26_06945 ENOG4105NHS Transcriptional regulator, TraR DksA family GEV26_06995 ENOG4105C0B DNA polymerase III (alpha subunit) GEV26_07005 ENOG4108Z66 YbaK ebsC protein GEV26_07010 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GEV26_07015 ENOG4105CIH Imidazole acetol-phosphate transaminase GEV26_07020 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GEV26_07025 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GEV26_07030 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GEV26_07040 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GEV26_07045 ENOG4105BZ1 (ABC) transporter GEV26_07050 ENOG4105BZ1 (ABC) transporter GEV26_07055 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GEV26_07070 ENOG4105W8D rdd domain containing protein GEV26_07080 ENOG4105DK0 Indole-3-glycerol phosphate synthase GEV26_07085 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GEV26_07090 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GEV26_07095 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GEV26_07115 ENOG4105CBC glutamate synthase GEV26_07125 ENOG4105CA9 Pyruvate kinase GEV26_07150 ENOG4108IV0 ABC, transporter GEV26_07155 ENOG4105C0Z ABC transporter GEV26_07160 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GEV26_07165 ENOG4105C32 Amino acid ABC transporter (Permease) GEV26_07170 ENOG4108UQV Membrane GEV26_07195 ENOG4108RG3 short-chain dehydrogenase reductase GEV26_07215 ENOG4108I69 Glycosyl transferases group 1 GEV26_07220 ENOG4108M6P methyltransferase GEV26_07225 ENOG41073B4 coagulation factor 5 8 type domain-containing protein GEV26_07245 ENOG4105DFM M18 family aminopeptidase GEV26_07250 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GEV26_07265 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GEV26_07270 ENOG4105I8R Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GEV26_07280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GEV26_07295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GEV26_07315 ENOG4105EXC Acyl-transferase GEV26_07325 ENOG4107UWP Major facilitator superfamily MFS_1 GEV26_07335 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GEV26_07355 ENOG4107W53 thymidine kinase GEV26_07365 ENOG4105EN6 Membrane GEV26_07370 ENOG4105C26 Dehydrogenase GEV26_07380 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GEV26_07405 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GEV26_07430 ENOG4107VEG TrkA-N domain protein GEV26_07435 ENOG4105C0X amino acid GEV26_07440 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GEV26_07445 ENOG4105R0I Feruloyl esterase GEV26_07450 ENOG4105C0R drug resistance transporter emrb qaca subfamily GEV26_07465 ENOG4107QM5 aconitate hydratase GEV26_07470 ENOG4105DFW ABC transporter GEV26_07475 ENOG4105C2J ABC transporter GEV26_07480 ENOG4107RNG ABC transporter GEV26_07500 ENOG4105D82 Glutamate dehydrogenase GEV26_07515 ENOG4105C5F glutamine synthetase GEV26_07525 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GEV26_07545 ENOG4105F6J Alpha beta hydrolase fold GEV26_07560 ENOG4105CHP RNA polymerase GEV26_07570 ENOG4105CHR reductase GEV26_07585 ENOG4105CKU formyltetrahydrofolate synthetase GEV26_07615 ENOG4107SCK Monooxygenase GEV26_07660 ENOG4105BZU Histidine kinase GEV26_07665 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_07670 ENOG4107QHE Choloylglycine hydrolase GEV26_07690 ENOG4107RSM transcriptional regulator GEV26_07695 ENOG4105CHR reductase GEV26_07725 ENOG41066F8 ROK family GEV26_07750 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GEV26_07760 ENOG4105C29 acyl-CoA thioesterase GEV26_07770 ENOG4105CHR reductase GEV26_07775 ENOG4105CHU acetyl-coa acetyltransferase GEV26_07785 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GEV26_07805 ENOG4107RY6 amino acid GEV26_07845 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GEV26_07850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GEV26_07855 ENOG4105CKW Inner membrane protein yedI GEV26_07860 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GEV26_07865 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GEV26_07875 ENOG4105CIE May be required for sporulation (By similarity) GEV26_07880 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GEV26_07885 ENOG4105BZA Phosphoglycerate kinase GEV26_07890 ENOG4105CP7 Triose-phosphate isomerase GEV26_07905 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GEV26_07920 ENOG4105C89 phosphohexose isomerase GEV26_07925 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GEV26_07935 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GEV26_08005 ENOG4105ECY inositol monophosphatase GEV26_08010 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GEV26_08035 ENOG4105DQE DNA ligase GEV26_08070 ENOG4105C3K feS assembly ATPase SufC GEV26_08075 ENOG4105C9B Cysteine desulfurase GEV26_08085 ENOG4105VG1 fes assembly suf system protein GEV26_08090 ENOG4105C5H ABC transporter GEV26_08100 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GEV26_08115 ENOG4105WKW Pfam:DUF1458 GEV26_08125 ENOG4105YVS arsR family transcriptional regulator GEV26_08130 ENOG4105EAC phosphoserine phosphatase GEV26_08135 ENOG4105DKW ABC transporter GEV26_08155 ENOG4108V1U phospholipid-binding protein GEV26_08170 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GEV26_08175 ENOG4105C1G acyl-Coa dehydrogenase GEV26_08180 ENOG4105C1G acyl-Coa dehydrogenase GEV26_08200 ENOG41081K0 peptidylprolyl cis-trans isomerase GEV26_08205 ENOG4105CQ7 ATP-dependent helicase GEV26_08220 ENOG4106BRA Membrane GEV26_08240 ENOG4105CJ1 ABC, transporter GEV26_08270 ENOG4105CSV Glutaminase GEV26_08275 ENOG4105ETE Transcriptional regulator (LacI family GEV26_08310 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GEV26_08315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GEV26_08325 ENOG4105CMR udp-glucose 4-epimerase GEV26_08340 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GEV26_08345 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GEV26_08355 ENOG4105K6V RNA polymerase GEV26_08370 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GEV26_08400 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GEV26_08420 ENOG4105CVK Glutamate decarboxylase GEV26_08430 ENOG4105E5D amino acid GEV26_08445 ENOG4107YEM Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GEV26_08470 ENOG4105DBV ornithine carbamoyltransferase GEV26_08475 ENOG4105CEU Arginine dihydrolase GEV26_08480 ENOG4105CSX c4-dicarboxylate anaerobic carrier GEV26_08520 ENOG4105EET magnesium chelatase GEV26_08525 ENOG4107KWJ von Willebrand factor, type A GEV26_08545 ENOG4107RT4 flavin reductase domain protein GEV26_08595 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GEV26_08605 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GEV26_08615 ENOG4105CPC Aldo Keto reductase GEV26_08620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GEV26_08630 ENOG4105D7N magnesium and cobalt transport protein CorA GEV26_08635 ENOG4105C8N cysteinyl-tRNA synthetase GEV26_08665 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GEV26_08680 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GEV26_08700 ENOG4105E5F proteasome GEV26_08705 ENOG4105E0A ABC, transporter GEV26_08710 ENOG4105TVJ transport system, permease GEV26_08715 ENOG4105DQ5 transport system permease protein GEV26_08730 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GEV26_08735 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GEV26_08745 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GEV26_08770 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GEV26_08780 ENOG4105HFS 5'-3' exonuclease GEV26_08795 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GEV26_08800 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GEV26_08805 ENOG4105Q70 GEV26_08820 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GEV26_08825 ENOG4107T8T UPF0173 metal-dependent hydrolase GEV26_08885 ENOG4108K01 transcriptional regulator GEV26_08900 ENOG4105D5Q Arginine ornithine antiporter GEV26_08905 ENOG4105CRK lysyL-tRNA synthetase GEV26_08925 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GEV26_08950 ENOG4107RTD sua5 ycio yrdc ywlc family protein GEV26_08955 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GEV26_08970 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GEV26_09005 ENOG4105C1G acyl-Coa dehydrogenase GEV26_09010 ENOG4105K6V RNA polymerase GEV26_09015 ENOG4105RNG membrane GEV26_09025 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GEV26_09045 ENOG4108UW8 fha domain-containing protein GEV26_09050 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GEV26_09100 ENOG4105C8Y Acetylornithine aminotransferase GEV26_09115 ENOG4105CH2 amidohydrolase GEV26_09140 ENOG4105WQ3 Rna-binding protein GEV26_09150 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GEV26_09155 ENOG4108URH decarboxylase GEV26_09185 ENOG4107Y2X deaminase GEV26_09210 ENOG4105E39 Enoyl-CoA hydratase GEV26_09215 ENOG410846T CoA-transferase family III GEV26_09235 ENOG4105D2B acyl-CoA dehydrogenase GEV26_09245 ENOG4105C29 acyl-CoA thioesterase GEV26_09260 ENOG4105CHR reductase GEV26_09275 ENOG4105CGU Enoyl-CoA hydratase GEV26_09295 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_09305 ENOG41076PI Short-chain dehydrogenase reductase Sdr GEV26_09310 ENOG4105DEF Extracellular solute-binding protein, family 5 GEV26_09315 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GEV26_09320 ENOG4105CHU acetyl-coa acetyltransferase GEV26_09335 ENOG4105C1G acyl-Coa dehydrogenase GEV26_09340 ENOG4108IV0 ABC, transporter GEV26_09345 ENOG4105C0Z ABC transporter GEV26_09355 ENOG4105CPC Aldo Keto reductase GEV26_09365 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_09370 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GEV26_09385 ENOG4105E2A Dehydrogenase GEV26_09400 ENOG4105CHR reductase GEV26_09415 ENOG4108R85 Short chain dehydrogenase GEV26_09435 ENOG4105D3W isochorismatase GEV26_09450 ENOG4105D2B acyl-CoA dehydrogenase GEV26_09460 ENOG4105CHR reductase GEV26_09480 ENOG4108IPT Naphthoate synthase GEV26_09485 ENOG4105CHR reductase GEV26_09500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GEV26_09515 ENOG4105C3U ABC transporter GEV26_09520 ENOG4105CC9 acyl-Coa dehydrogenase GEV26_09525 ENOG4108KC2 acyl-Coa dehydrogenase GEV26_09530 ENOG4105CC9 acyl-Coa dehydrogenase GEV26_09535 ENOG4105D2B acyl-CoA dehydrogenase GEV26_09540 ENOG4105E39 Enoyl-CoA hydratase GEV26_09555 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_09565 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_09570 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GEV26_09585 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GEV26_09590 ENOG4105E39 Enoyl-CoA hydratase GEV26_09595 ENOG4105CC9 acyl-Coa dehydrogenase GEV26_09600 ENOG4105D2B acyl-CoA dehydrogenase GEV26_09605 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_09615 ENOG4105DEF Extracellular solute-binding protein, family 5 GEV26_09620 ENOG4105CHU acetyl-coa acetyltransferase GEV26_09625 ENOG4105CC9 acyl-Coa dehydrogenase GEV26_09630 ENOG4105E39 Enoyl-CoA hydratase GEV26_09650 ENOG4105C1G acyl-Coa dehydrogenase GEV26_09655 ENOG4105CHU acetyl-coa acetyltransferase GEV26_09660 ENOG4105C29 acyl-CoA thioesterase GEV26_09675 ENOG4108Z4U Ferredoxin GEV26_09685 ENOG4105C26 Dehydrogenase GEV26_09690 ENOG41076PI Short-chain dehydrogenase reductase Sdr GEV26_09695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GEV26_09710 ENOG4105DYW oxidoreductase GEV26_09715 ENOG4107UWP Major facilitator superfamily MFS_1 GEV26_09735 ENOG4105C29 acyl-CoA thioesterase GEV26_09740 ENOG4105FDP GntR family transcriptional regulator GEV26_09745 ENOG4105CHR reductase GEV26_09770 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GEV26_09775 ENOG4105CAT Cytidine monophosphate kinase GEV26_09790 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GEV26_09795 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GEV26_09820 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GEV26_09835 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GEV26_09840 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GEV26_09855 ENOG4105DSU hydrolase GEV26_09885 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GEV26_09890 ENOG4105SHT UspA domain-containing protein GEV26_09900 ENOG4105SHT UspA domain-containing protein GEV26_09920 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GEV26_09925 ENOG4108V9W transcriptional regulatory protein GEV26_09930 ENOG4108VX5 3-methyladenine DNA glycosylase GEV26_09935 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GEV26_09940 ENOG4105CH7 arginosuccinase GEV26_09945 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GEV26_09950 ENOG4105DBV ornithine carbamoyltransferase GEV26_09955 ENOG4105C8Y Acetylornithine aminotransferase GEV26_09960 ENOG4105CAS nag kinase GEV26_09965 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GEV26_09970 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GEV26_09975 ENOG4105CDH Citrulline--aspartate ligase GEV26_09985 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GEV26_09990 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GEV26_09995 ENOG4105BZU Histidine kinase GEV26_10000 ENOG4108RWN rrna methyltransferase GEV26_10005 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GEV26_10010 ENOG41084BS 50S ribosomal protein L35 GEV26_10015 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GEV26_10045 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GEV26_10050 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GEV26_10055 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GEV26_10060 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GEV26_10075 ENOG4105DJV ribulose-phosphate 3-epimerase GEV26_10090 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GEV26_10100 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GEV26_10110 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GEV26_10115 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GEV26_10130 ENOG4105SKN orotidine 5''-phosphate decarboxylase GEV26_10135 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GEV26_10140 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GEV26_10145 ENOG4105CD3 dihydroorotase GEV26_10150 ENOG4105CXT aspartate transcarbamylase GEV26_10155 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GEV26_10165 ENOG410803B Involved in the transcription termination process (By similarity) GEV26_10170 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GEV26_10175 ENOG4105DC7 peptidase M24 GEV26_10180 ENOG4105D49 3-dehydroquinate synthase GEV26_10185 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GEV26_10190 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GEV26_10200 ENOG4105E2X shikimate dehydrogenase GEV26_10210 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GEV26_10215 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GEV26_10235 ENOG4105C9M aspartyl-trna synthetase GEV26_10240 ENOG4105CUT histidyl-tRNA synthetase GEV26_10250 ENOG4105C99 atpase involved in dna repair GEV26_10260 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GEV26_10265 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GEV26_10270 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GEV26_10275 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GEV26_10280 ENOG4105ZCJ preprotein translocase subunit yajC GEV26_10285 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GEV26_10290 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GEV26_10295 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GEV26_10300 ENOG4105CDY transcriptional regulatory protein GEV26_10305 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GEV26_10310 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GEV26_10325 ENOG4105CHH sulfate transporter GEV26_10330 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GEV26_10345 ENOG4105C22 threonyL-tRNA synthetase GEV26_10350 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_10370 ENOG4107RN6 Monooxygenase GEV26_10390 ENOG4105CIG ABC transporter GEV26_10415 ENOG4105CM2 brancheD-chain amino acid aminotransferase GEV26_10445 ENOG4106032 Glutathionylspermidine synthase GEV26_10470 ENOG4105CSU acyl-Coa dehydrogenase GEV26_10490 ENOG4108KK1 membrane protein AbrB duplication GEV26_10495 ENOG4105CSR polyphosphate kinase 2 GEV26_10510 ENOG4105E0X reductase GEV26_10515 ENOG4107JTW chlorite dismutase GEV26_10520 ENOG4105C1Q protoporphyrinogen oxidase GEV26_10525 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GEV26_10540 ENOG4105EKT )-iron permease GEV26_10550 ENOG4107SET aldo keto reductase GEV26_10560 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GEV26_10630 ENOG4105DYS nad(p)h dehydrogenase (quinone) GEV26_10650 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GEV26_10660 ENOG4105P52 geranylgeranyl reductase GEV26_10685 ENOG4105BZU Histidine kinase GEV26_10700 ENOG4107G87 m6 family metalloprotease domain protein GEV26_10710 ENOG4105VEQ Cold shock protein GEV26_10730 ENOG41080RH Thioredoxin GEV26_10770 ENOG4105C0D helicase GEV26_10810 ENOG4108DT4 serine threonine protein kinase GEV26_10840 ENOG4105C0D helicase GEV26_10845 ENOG4105C7H Helicase, RecD TraA family GEV26_10850 ENOG4107QKA exodeoxyribonuclease V beta GEV26_10855 ENOG4105DSY exodeoxyribonuclease V, gamma GEV26_10870 ENOG4107SCA Formamidase (EC 3.5.1.49) GEV26_10935 ENOG4108IMY Transcriptional regulator GEV26_10950 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GEV26_11015 ENOG4105C0D helicase GEV26_11025 ENOG4105DEN Luciferase family GEV26_11030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GEV26_11035 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GEV26_11055 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GEV26_11065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GEV26_11080 ENOG4105CHR reductase GEV26_11085 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GEV26_11110 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GEV26_11115 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GEV26_11120 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GEV26_11145 ENOG4105EYF MMPL domain protein GEV26_11155 ENOG4107YPT transcriptional regulator GEV26_11160 ENOG4105C1G acyl-Coa dehydrogenase GEV26_11165 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GEV26_11205 ENOG4105CDA abc transporter atp-binding protein GEV26_11210 ENOG4107UBR Extracellular solute-binding protein family 3 GEV26_11215 ENOG4108Q1T ABC transporter GEV26_11220 ENOG4105DRP amino acid AbC transporter GEV26_11250 ENOG4105KC9 Modulates RecA activity (By similarity) GEV26_11255 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GEV26_11265 ENOG4105ETE Transcriptional regulator (LacI family GEV26_11275 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GEV26_11290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GEV26_11305 ENOG4105CEV competence damage-inducible protein GEV26_11320 ENOG4107QZI cell division protein FtsK GEV26_11330 ENOG4105CVM Molybdenum cofactor synthesis domain protein GEV26_11345 ENOG4105CN5 Metallo-Beta-Lactamase GEV26_11350 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GEV26_11380 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GEV26_11405 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GEV26_11420 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GEV26_11430 ENOG4108VQR secreted hydrolase GEV26_11445 ENOG4105GR3 Histidine kinase GEV26_11450 ENOG4105ETX regulatoR GEV26_11455 ENOG4107QPV Serine Threonine protein kinase GEV26_11465 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GEV26_11470 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GEV26_11475 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GEV26_11495 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GEV26_11510 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GEV26_11530 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GEV26_11535 ENOG4105DZP Membrane-associated zinc metalloprotease GEV26_11550 ENOG4105CJ1 ABC, transporter GEV26_11555 ENOG4105BZU Histidine kinase GEV26_11560 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_11590 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GEV26_11595 ENOG4105D38 putrescine abc transporter GEV26_11600 ENOG4105F38 ABC transporter, permease GEV26_11605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GEV26_11635 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GEV26_11650 ENOG4105NPQ Pfam:DUF403 GEV26_11665 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GEV26_11670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GEV26_11675 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GEV26_11680 ENOG4105CE9 30S ribosomal protein S2 GEV26_11685 ENOG4105E4C Lytic transglycosylase catalytic GEV26_11705 ENOG4105C0P Mg chelatase subunit ChlI GEV26_11710 ENOG41080R2 UPF0102 protein GEV26_11715 ENOG4108374 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GEV26_11725 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GEV26_11740 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GEV26_11750 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GEV26_11755 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GEV26_11760 ENOG41082KU UPF0109 protein GEV26_11765 ENOG4105K5M 30s ribosomal protein S16 GEV26_11780 ENOG4105K89 arsenate reductase GEV26_11795 ENOG4105C6Z Gluconate GEV26_11800 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GEV26_11815 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GEV26_11835 ENOG4108JJ8 (ABC) transporter GEV26_11840 ENOG4108JJ9 ABC, transporter GEV26_11845 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GEV26_11850 ENOG4105C4M (Ubiquinol oxidase) subunit I GEV26_11875 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GEV26_11895 ENOG4105C2W permease GEV26_11910 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GEV26_11915 ENOG4105DSE periplasmic solute binding protein GEV26_11920 ENOG4105DIK (ABC) transporter GEV26_11980 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GEV26_11990 ENOG4108IJ0 Aspartate ammonia-lyase GEV26_11995 ENOG4105CM2 brancheD-chain amino acid aminotransferase GEV26_12000 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GEV26_12025 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GEV26_12030 ENOG4108ZP8 Acetolactate synthase small subunit GEV26_12060 ENOG4105C01 Dihydroxy-acid dehydratase GEV26_12085 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GEV26_12095 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GEV26_12100 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GEV26_12105 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GEV26_12130 ENOG4108JU3 Alkyl hydroperoxide reductase GEV26_12135 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GEV26_12145 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GEV26_12160 ENOG4107QI6 Cysteine desulfurase GEV26_12165 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GEV26_12170 ENOG4108IYU L-aspartate oxidase GEV26_12175 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GEV26_12185 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GEV26_12195 ENOG4105BZU Histidine kinase GEV26_12200 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_12210 ENOG4105C0B DNA polymerase III (alpha subunit) GEV26_12230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GEV26_12235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GEV26_12240 ENOG4107QSI ABC, transporter GEV26_12245 ENOG4105C10 Electron transfer flavoprotein GEV26_12250 ENOG4105BZJ Electron transfer flavoprotein GEV26_12285 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GEV26_12290 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GEV26_12295 ENOG4105CG3 alpha amylase, catalytic region GEV26_12300 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GEV26_12365 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GEV26_12370 ENOG4105M6F mutator MutT protein GEV26_12395 ENOG4105CHU acetyl-coa acetyltransferase GEV26_12435 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GEV26_12440 ENOG4107YEV ferritin GEV26_12445 ENOG4105RFZ Methylmalonyl-coA mutase GEV26_12465 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GEV26_12470 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GEV26_12475 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GEV26_12480 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GEV26_12485 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GEV26_12490 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GEV26_12495 ENOG4106DE0 ATP synthase GEV26_12500 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) GEV26_12510 ENOG4105ESV Glycosyl transferase, family 4 GEV26_12525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GEV26_12530 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GEV26_12535 ENOG4105VFB Binds the 23S rRNA (By similarity) GEV26_12540 ENOG4105H3G oxidoreductase GEV26_12545 ENOG4105C09 Bile acid GEV26_12575 ENOG4105D6E homoserine dehydrogenase GEV26_12590 ENOG4108Z4X TRANSCRIPTIONal GEV26_12595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GEV26_12600 ENOG4105C75 arginyL-tRNA synthetase GEV26_12605 ENOG4105ETX regulatoR GEV26_12630 ENOG4108NNZ chitinase GEV26_12640 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GEV26_12655 ENOG4105CB2 alcohol dehydrogenase GEV26_12690 ENOG4105BZ1 (ABC) transporter GEV26_12755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GEV26_12760 ENOG4105BZU Histidine kinase GEV26_12765 ENOG4105EDW glycosyl transferase, family 39 GEV26_12770 ENOG4105CKK Glycosyl transferase, family 2 GEV26_12790 ENOG4107S4F acyltransferase, ws dgat mgat GEV26_12825 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GEV26_12830 ENOG4105T0Z Conserved Protein GEV26_12835 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_12840 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GEV26_12845 ENOG4105MJ2 Competence protein GEV26_12850 ENOG4105G3P Lipoprotein lpqB GEV26_12855 ENOG4105BZU Histidine kinase GEV26_12860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GEV26_12865 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GEV26_12900 ENOG4105W49 UPF0434 protein GEV26_12930 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GEV26_12950 ENOG4105EY8 ABC transporter GEV26_12955 ENOG4108KGH TRANSCRIPTIONal GEV26_12965 ENOG4108KGH TRANSCRIPTIONal GEV26_12975 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GEV26_12990 ENOG4108Z4U Ferredoxin GEV26_13005 ENOG4105MXW flavin reductase domain protein, FMN-binding GEV26_13015 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GEV26_13040 ENOG4105QE3 oxidoreductase GEV26_13045 ENOG4105C09 Bile acid GEV26_13080 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GEV26_13090 ENOG4105C57 major facilitator superfamily GEV26_13125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GEV26_13165 ENOG4105C3G gtp-binding protein GEV26_13210 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GEV26_13215 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GEV26_13225 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GEV26_13230 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GEV26_13255 ENOG4105F4R Transcriptional regulator mode GEV26_13285 ENOG4105C9Q fumarate hydratase class II GEV26_13300 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GEV26_13315 ENOG4108IAB Phoh family GEV26_13320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GEV26_13330 ENOG4105C7Z Conserved Protein GEV26_13355 ENOG4105T1M mycothiol conjugate amidase mca GEV26_13365 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GEV26_13370 ENOG4105C7B Threonine dehydratase GEV26_13380 ENOG4105MSB protein, conserved in bacteria GEV26_13390 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GEV26_13400 ENOG4108VCA G U mismatch-specific DNA glycosylase GEV26_13405 ENOG4105KVH Transcriptional regulator GEV26_13410 ENOG4105ECR NmrA family GEV26_13415 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GEV26_13425 ENOG4105EUB pirin domain protein GEV26_13440 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GEV26_13450 ENOG4106YT9 Enoyl-CoA hydratase GEV26_13460 ENOG4105CPC Aldo Keto reductase GEV26_13495 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase GEV26_13500 ENOG4108Q52 Methyltransferase cognate corrinoid protein GEV26_13510 ENOG4105F5V trimethylamine methyltransferase GEV26_13520 ENOG4105J4Q Transcriptional regulator GEV26_13525 ENOG4105C26 Dehydrogenase GEV26_13535 ENOG4108IJ7 Glycine betaine GEV26_13540 ENOG4108HQS Glycine betaine GEV26_13555 ENOG4105BZJ Electron transfer flavoprotein GEV26_13560 ENOG4105C10 Electron transfer flavoprotein GEV26_13565 ENOG4105C5I Dehydrogenase GEV26_13580 ENOG4105DET Rhamnulokinase GEV26_13595 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GEV26_13605 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GEV26_13610 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GEV26_13615 ENOG4105C2J ABC transporter GEV26_13620 ENOG4105ETE Transcriptional regulator (LacI family GEV26_13625 ENOG4105DEI Mannitol dehydrogenase GEV26_13635 ENOG4107QJT sodium dicarboxylate symporter GEV26_13650 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GEV26_13665 ENOG4105CUB amino acid GEV26_13690 ENOG4105CKK Glycosyl transferase, family 2 GEV26_13695 ENOG4108KGH TRANSCRIPTIONal GEV26_13710 ENOG4105D9R oxidoreductase GEV26_13740 ENOG4107EF8 Glycosyl transferase (Group 1 GEV26_13830 ENOG4105D3Q Sugar transferase GEV26_13835 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GEV26_13840 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GEV26_13845 ENOG4105BZU Histidine kinase GEV26_13865 ENOG4108KXV response regulator GEV26_13870 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GEV26_13885 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GEV26_13890 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GEV26_13900 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GEV26_13910 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GEV26_13915 ENOG4105C5H ABC transporter GEV26_13925 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GEV26_13935 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GEV26_13940 ENOG4106839 domain protein GEV26_13945 ENOG4105F8V Hydrolase, tatD family GEV26_13950 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GEV26_13995 ENOG4105VCQ rubredoxin GEV26_14000 ENOG41084UD rubredoxin GEV26_14005 ENOG4105EEF Alkane 1-monooxygenase GEV26_14015 ENOG4105DU6 RNA polymerase GEV26_14025 ENOG4105CV8 reductase GEV26_14050 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GEV26_14055 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GEV26_14070 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GEV26_14100 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GEV26_14130 ENOG4105D7N magnesium and cobalt transport protein CorA GEV26_14145 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GEV26_14150 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GEV26_14155 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GEV26_14165 ENOG4105DFH Transport of potassium into the cell (By similarity) GEV26_14180 ENOG4107QN2 dihydrolipoyl dehydrogenase GEV26_14190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GEV26_14205 ENOG4105CVP deoxyribo-dipyrimidine photolyase GEV26_14215 ENOG4105EV4 Multidrug resistance protein mdtH GEV26_14235 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GEV26_14280 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GEV26_14285 ENOG4108Z0R Transferase GEV26_14290 ENOG4105C7N Xanthine uracil vitamin C permease GEV26_14315 ENOG4108N0W Major Facilitator superfamily GEV26_14320 ENOG4105VEQ Cold shock protein GEV26_14325 ENOG4107H3J ribonuclease GEV26_14335 ENOG4105EMN RNA polymerase sigma factor GEV26_14345 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_14350 ENOG4105D3Q Sugar transferase GEV26_14360 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase GEV26_14400 ENOG4105C26 Dehydrogenase GEV26_14405 ENOG4107RR1 TRANSCRIPTIONal GEV26_14410 ENOG4105D7W serine acetyltransferase GEV26_14420 ENOG4105CJ1 ABC, transporter GEV26_14425 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GEV26_14430 ENOG4105F27 Major Facilitator GEV26_14440 ENOG4105E9K Isocitrate dehydrogenase GEV26_14445 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GEV26_14455 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GEV26_14470 ENOG4105VMP Transcriptional regulator GEV26_14475 ENOG4105DC1 bifunctional purine biosynthesis protein purh GEV26_14500 ENOG4105CMV Succinyl-CoA synthetase subunit beta GEV26_14525 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GEV26_14535 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GEV26_14545 ENOG4105WH1 Two component transcriptional regulator luxr family GEV26_14565 ENOG41067S9 phage shock protein C, PspC GEV26_14570 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GEV26_14580 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GEV26_14585 ENOG4105BZP glycoside hydrolase 15-related GEV26_14605 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GEV26_14620 ENOG4105DBE peroxidase GEV26_14640 ENOG4107QVP Dehydrogenase GEV26_14650 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GEV26_14665 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GEV26_14670 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GEV26_14675 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GEV26_14690 ENOG4105E7W lamb ycsf family protein GEV26_14695 ENOG4105P4J Allophanate hydrolase, subunit 1 GEV26_14705 ENOG4105D17 glycoside hydrolase, family 3 domain protein GEV26_14710 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GEV26_14745 ENOG4108097 ATP-binding protein GEV26_14755 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GEV26_14765 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GEV26_14770 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GEV26_14775 ENOG4105CS9 pantothenic acid kinase GEV26_14795 ENOG4105D9P serine threonine protein kinase GEV26_14800 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GEV26_14805 ENOG4108UJD 30S ribosomal protein S9 GEV26_14810 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GEV26_14820 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GEV26_14825 ENOG4105KNA -acetyltransferase GEV26_14840 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GEV26_14845 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GEV26_14850 ENOG4108ZT0 50S ribosomal protein l17 GEV26_14855 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GEV26_14860 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GEV26_14865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GEV26_14870 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GEV26_14875 ENOG41067V7 50S ribosomal protein L36 GEV26_14880 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GEV26_14885 ENOG4105EW9 transcriptional regulator AsnC family GEV26_14890 ENOG4105CIK Amidinotransferase GEV26_14910 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GEV26_14920 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GEV26_14925 ENOG410849U 50S ribosomal protein L30 GEV26_14930 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GEV26_14935 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GEV26_14940 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GEV26_14945 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GEV26_14950 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GEV26_14955 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GEV26_14960 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GEV26_14965 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GEV26_14970 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GEV26_14975 ENOG41082SA 50s ribosomal protein l29 GEV26_14980 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GEV26_14985 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GEV26_14990 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GEV26_14995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GEV26_15000 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GEV26_15005 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GEV26_15010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GEV26_15015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GEV26_15020 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GEV26_15030 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GEV26_15035 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GEV26_15040 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GEV26_15045 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GEV26_15055 ENOG4105CQB FAD linked oxidase domain protein GEV26_15065 ENOG4107XBN GntR Family Transcriptional Regulator GEV26_15080 ENOG4108TGC Acyltransferase GEV26_15090 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GEV26_15095 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GEV26_15155 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GEV26_15165 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GEV26_15170 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GEV26_15175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GEV26_15205 ENOG4107R4N Cell wall formation (By similarity) GEV26_15210 ENOG4105WDJ 50S ribosomal protein L33 GEV26_15240 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GEV26_15250 ENOG4105EYW Ion transport protein GEV26_15255 ENOG4105F8J Adenylate Guanylate cyclase GEV26_15290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GEV26_15315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GEV26_15340 ENOG4107GJV short-chain dehydrogenase reductase GEV26_15355 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GEV26_15420 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GEV26_15425 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GEV26_15430 ENOG4107HP6 Transcriptional regulator GEV26_15445 ENOG4105E2A Dehydrogenase GEV26_15460 ENOG4105DMF Dehydrogenase GEV26_15465 ENOG4105KJM monovalent cation h antiporter subunit g GEV26_15480 ENOG4108JPZ Monovalent cation H antiporter subunit D GEV26_15485 ENOG4105MKQ Monovalent cation H antiporter subunit C GEV26_15490 ENOG4105D65 subunit l GEV26_15525 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GEV26_15530 ENOG4105C32 Amino acid ABC transporter (Permease) GEV26_15535 ENOG4108IV0 ABC, transporter GEV26_15540 ENOG4108IUZ ABC transporter GEV26_15555 ENOG4108VPT UPF0234 protein GEV26_15560 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15565 ENOG4105C8S subunit m GEV26_15575 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15585 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15590 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GEV26_15600 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15605 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GEV26_15610 ENOG4105EMU Dehydrogenase GEV26_15630 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15640 ENOG4105D65 subunit l GEV26_15645 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15650 ENOG4105DF2 NADH dehydrogenase subunit j GEV26_15655 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15660 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GEV26_15665 ENOG4108IEH NADH dehydrogenase subunit g GEV26_15670 ENOG4107QIZ NADH dehydrogenase GEV26_15680 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15685 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GEV26_15690 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_15700 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GEV26_15705 ENOG4105E4F Isochorismate synthase GEV26_15715 ENOG41090WU lipolytic protein G-D-S-L family GEV26_15720 ENOG4107SM8 Adenylate Guanylate cyclase GEV26_15725 ENOG4105C26 Dehydrogenase GEV26_15735 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GEV26_15740 ENOG4107TCW O-succinylbenzoate synthase GEV26_15790 ENOG4105CJ1 ABC, transporter GEV26_15800 ENOG4105CRE cytochrome C GEV26_15810 ENOG4107QIV Cytochrome c biogenesis protein GEV26_15820 ENOG4108RH7 phosphoglycerate mutase GEV26_15825 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GEV26_15835 ENOG4105D52 delta-aminolevulinic acid dehydratase GEV26_15845 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GEV26_15850 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GEV26_15855 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GEV26_15865 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_15870 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GEV26_15905 ENOG4105DGU Histone deacetylase GEV26_15910 ENOG4105II7 pyrroline-5-carboxylate reductase GEV26_15915 ENOG4105DHU Bile acid GEV26_15920 ENOG410829K Lysine exporter protein (Lyse ygga) GEV26_15925 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GEV26_15930 ENOG4107R33 ppx gppa phosphatase GEV26_15935 ENOG4108JWX GEV26_15955 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GEV26_15965 ENOG4105CEN a g-specific adenine glycosylase GEV26_15970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GEV26_15985 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GEV26_15990 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GEV26_15995 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GEV26_16005 ENOG4105K64 Glycosyl transferase, family 2 GEV26_16020 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GEV26_16055 ENOG4105EUJ GTP cyclohydrolase i GEV26_16070 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GEV26_16080 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GEV26_16085 ENOG4105F0N pyrophosphate phospho-hydrolase GEV26_16095 ENOG4105D8V Glucose sorbosone dehydrogenase GEV26_16105 ENOG4107RN6 Monooxygenase GEV26_16115 ENOG4105EC2 ftsk spoIIIe GEV26_16140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GEV26_16190 ENOG4107SET aldo keto reductase GEV26_16195 ENOG4105W1Y Transcriptional regulator GEV26_16210 ENOG4105C57 major facilitator superfamily GEV26_16215 ENOG4105CUB amino acid GEV26_16225 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GEV26_16245 ENOG4108ZHJ Organic hydroperoxide resistance protein GEV26_16260 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GEV26_16265 ENOG4105E39 Enoyl-CoA hydratase GEV26_16270 ENOG4108YZT Adenosylcobinamide kinase GEV26_16280 ENOG4105VEQ Cold shock protein GEV26_16290 ENOG4105BZ1 (ABC) transporter GEV26_16340 ENOG41090MY MarR family Transcriptional regulator GEV26_16350 ENOG4105D5P Methylmalonyl-coA mutase GEV26_16355 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GEV26_16365 ENOG4105EF1 ribulokinase GEV26_16370 ENOG4105ETE Transcriptional regulator (LacI family GEV26_16375 ENOG41062B0 ABC transporter, permease GEV26_16380 ENOG4107R9N ABC transporter GEV26_16385 ENOG4105C2J ABC transporter GEV26_16390 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GEV26_16395 ENOG4105EXC Acyl-transferase GEV26_16410 ENOG4108UKI Enoyl-CoA hydratase GEV26_16415 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase GEV26_16425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GEV26_16480 ENOG4105C1G acyl-Coa dehydrogenase GEV26_16510 ENOG4105D5Q Arginine ornithine antiporter GEV26_16550 ENOG4108ZJI phenylacetic acid degradation protein GEV26_16555 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GEV26_16560 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GEV26_16565 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GEV26_16570 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GEV26_16575 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GEV26_16580 ENOG4105DXM phenylacetic acid degradation protein GEV26_16600 ENOG4107QSN dihydrolipoamide acetyltransferase GEV26_16640 ENOG4105CEY Amp-dependent synthetase and ligase GEV26_16650 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GEV26_16670 ENOG4105KNI merR family transcriptional Regulator GEV26_16675 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GEV26_16680 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GEV26_16685 ENOG4105CFG Acts as a chaperone (By similarity) GEV26_16700 ENOG4105EYF MMPL domain protein GEV26_16705 ENOG4108JGH Tetr family transcriptional regulator GEV26_16720 ENOG4105C72 UPF0176 protein GEV26_16745 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GEV26_16750 ENOG4108R85 Short chain dehydrogenase GEV26_16770 ENOG4108JJB ABC transporter GEV26_16775 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GEV26_16780 ENOG4105CJP fad dependent oxidoreductase GEV26_16805 ENOG4105E5T Major Facilitator Superfamily GEV26_16810 ENOG4105ECQ AraC Family Transcriptional Regulator GEV26_16815 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GEV26_16820 ENOG4105DF6 Fe-S oxidoreductase GEV26_16825 ENOG4105K5B UPF0225 protein GEV26_16835 ENOG4105CJ1 ABC, transporter GEV26_16840 ENOG4107QKS N-acylglucosamine 2-epimerase GEV26_16845 ENOG4108KPW sugar kinase GEV26_16855 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GEV26_16860 ENOG4105DHP deoxycytidine triphosphate deaminase GEV26_16870 ENOG4105I4A GCN5-related N-acetyltransferase GEV26_16905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GEV26_16915 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GEV26_16935 ENOG4108KHP Diguanylate cyclase GEV26_16945 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GEV26_16950 ENOG4105JQN Transcriptional regulator GEV26_16960 ENOG4105CSU acyl-Coa dehydrogenase GEV26_16980 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GEV26_16995 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GEV26_17000 ENOG4105CPP Dehydrogenase, E1 component GEV26_17010 ENOG4105CIH Imidazole acetol-phosphate transaminase GEV26_17015 ENOG4108UZ3 Transporter GEV26_17020 ENOG41082T9 Membrane GEV26_17025 ENOG4105KJF protein tyrosine phosphatase GEV26_17045 ENOG4105C0H protease GEV26_17050 ENOG4107Y9U Membrane GEV26_17065 ENOG4107EFR Flavocytochrome c GEV26_17075 ENOG4105CHR reductase GEV26_17080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GEV26_17090 ENOG4105C26 Dehydrogenase GEV26_17100 ENOG4105CNN ABC, transporter GEV26_17105 ENOG4105C2J ABC transporter GEV26_17130 ENOG4108UAU isochorismatase GEV26_17165 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GEV26_17195 ENOG4105CDA abc transporter atp-binding protein GEV26_17220 ENOG4107QX3 carboxylase GEV26_17225 ENOG4105C1G acyl-Coa dehydrogenase GEV26_17240 ENOG4108RF4 Tetr family transcriptional regulator GEV26_17270 ENOG4107YPT transcriptional regulator GEV26_17290 ENOG4105DWV Homoserine O-trans-acetylase GEV26_17365 ENOG4105CGU Enoyl-CoA hydratase GEV26_17370 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GEV26_17390 ENOG4105CGD Nad-dependent epimerase dehydratase GEV26_17395 ENOG4108TM9 integral membrane protein GEV26_17400 ENOG4105CUB amino acid GEV26_17430 ENOG4105E0A ABC, transporter GEV26_17435 ENOG4105TVJ transport system, permease GEV26_17440 ENOG4105DQ5 transport system permease protein GEV26_17445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GEV26_17450 ENOG4105CHU acetyl-coa acetyltransferase GEV26_17465 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GEV26_17470 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GEV26_17480 ENOG4105H3G oxidoreductase GEV26_17495 ENOG4105E5Q amino acid AbC transporter GEV26_17500 ENOG4105EAB amino acid AbC transporter GEV26_17510 ENOG4105U3E Transcriptional regulator GEV26_17525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GEV26_17545 ENOG4108JQ1 Dehydrogenase GEV26_17560 ENOG4105VPX protein, conserved in bacteria GEV26_17585 ENOG4105BZ1 (ABC) transporter GEV26_17595 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GEV26_17600 ENOG4107T5V SNARE associated Golgi GEV26_17610 ENOG4105CDU Replicative dna helicase GEV26_17625 ENOG4105HJK ABC transporter GEV26_17630 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GEV26_17635 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GEV26_17645 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GEV26_17665 ENOG4105CQ7 ATP-dependent helicase GEV26_17670 ENOG4105CPC Aldo Keto reductase GEV26_17715 ENOG4105BZ4 penicillin-binding protein GEV26_17725 ENOG4105CZA synthase GEV26_17740 ENOG4105C0Z ABC transporter GEV26_17745 ENOG4108IV0 ABC, transporter GEV26_17750 ENOG4105C32 Amino acid ABC transporter (Permease) GEV26_17755 ENOG4105CNN ABC, transporter GEV26_17765 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GEV26_17785 ENOG4105C3M thioredoxin reductase GEV26_17790 ENOG4105K63 Thioredoxin GEV26_17800 ENOG4107QJE Chromosome Partitioning Protein GEV26_17805 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GEV26_17815 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GEV26_17820 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GEV26_17825 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)