locus-tag	class	description
NP095_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP095_00010	COG0592	DNA-directed DNA polymerase activity
NP095_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NP095_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP095_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NP095_00035	COG4214	carbohydrate transport
NP095_00045	COG4213	ABC transporter substrate-binding protein
NP095_00050	COG1349	DNA-binding transcription factor activity
NP095_00065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP095_00070	COG0588	phosphoglycerate mutase activity
NP095_00075	COG0187	DNA topoisomerase II activity
NP095_00080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP095_00120	COG1216	Glycosyl transferase, family 2
NP095_00125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NP095_00150	COG0142	geranyltranstransferase activity
NP095_00180	COG0589	response to stress
NP095_00210	COG4172	Belongs to the ABC transporter superfamily
NP095_00215	COG0601	transmembrane transport
NP095_00220	COG4166	transmembrane transport
NP095_00225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP095_00240	COG1476	TRANSCRIPTIONal
NP095_00255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP095_00260	COG0705	Rhomboid family
NP095_00275	COG0515	serine threonine protein kinase
NP095_00280	COG0768	penicillin binding
NP095_00295	COG1716	ATPase activity
NP095_00330	COG1024	Enoyl-CoA hydratase
NP095_00340	COG1739	Uncharacterized protein family UPF0029
NP095_00350	COG0477	Major facilitator Superfamily
NP095_00365	COG0697	spore germination
NP095_00370	COG1309	transcriptional regulator
NP095_00375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP095_00400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NP095_00405	COG0776	regulation of translation
NP095_00415	COG2409	Drug exporters of the RND superfamily
NP095_00425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP095_00425	COG0425	Belongs to the sulfur carrier protein TusA family
NP095_00455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP095_00460	COG0561	phosphatase activity
NP095_00465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP095_00485	COG0494	nUDIX hydrolase
NP095_00535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP095_00550	COG1131	(ABC) transporter
NP095_00555	COG4585	Histidine kinase
NP095_00560	COG2197	response regulator
NP095_00565	COG1408	metallophosphoesterase
NP095_00575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP095_00590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP095_00595	COG2076	Multidrug Resistance protein
NP095_00635	COG1960	acyl-CoA dehydrogenase activity
NP095_00640	COG1960	acyl-CoA dehydrogenase activity
NP095_00645	COG0095	Lipoate-protein ligase
NP095_00665	COG2205	protein histidine kinase activity
NP095_00670	COG0745	RESPONSE REGULATOR receiver
NP095_00685	COG0433	COG0433 Predicted ATPase
NP095_00700	COG3263	regulation of cellular component size
NP095_00715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_00755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_00760	COG0590	tRNA wobble adenosine to inosine editing
NP095_00770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP095_00775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP095_00780	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NP095_00785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NP095_00805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP095_00855	COG2409	Drug exporters of the RND superfamily
NP095_00895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP095_00900	COG0604	alcohol dehydrogenase
NP095_00900	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_00900	COG3321	synthase
NP095_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP095_00935	COG1122	ATPase activity
NP095_00950	COG0456	acetyltransferase
NP095_00960	COG3275	phosphorelay sensor kinase activity
NP095_01020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP095_01025	COG1111	helicase
NP095_01025	COG1205	dead DEAH box helicase
NP095_01030	COG1366	Belongs to the anti-sigma-factor antagonist family
NP095_01035	COG2890	protein-(glutamine-N5) methyltransferase activity
NP095_01045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP095_01045	COG1754	DNA topoisomerase type I activity
NP095_01055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP095_01060	COG0470	DNA polymerase III
NP095_01070	COG1605	Chorismate mutase
NP095_01070	COG0287	Prephenate dehydrogenase
NP095_01135	COG1597	lipid kinase activity
NP095_01150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NP095_01185	COG0151	Belongs to the GarS family
NP095_01195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP095_01210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP095_01215	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_01225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP095_01280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP095_01305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP095_01305	COG0047	phosphoribosylformylglycinamidine synthase activity
NP095_01320	COG0306	phosphate transporter
NP095_01325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP095_01355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NP095_01365	COG0657	acetylesterase activity
NP095_01370	COG0456	acetyltransferase
NP095_01400	COG0745	RESPONSE REGULATOR receiver
NP095_01435	COG1832	CoA-binding protein
NP095_01445	COG1490	D-aminoacyl-tRNA deacylase activity
NP095_01450	COG4044	May play a role in the intracellular transport of hydrophobic ligands
NP095_01455	COG0354	folic acid binding
NP095_01505	COG1217	gtp-binding protein TYPA
NP095_01515	COG0477	Major facilitator Superfamily
NP095_01525	COG1280	lysine exporter protein (LysE YggA)
NP095_01550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP095_01555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP095_01580	COG1741	Belongs to the pirin family
NP095_01590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NP095_01600	COG1320	monovalent cation:proton antiporter activity
NP095_01605	COG2212	antiporter activity
NP095_01615	COG0651	ATP synthesis coupled electron transport
NP095_01620	COG1006	Multisubunit Na H antiporter MnhC subunit
NP095_01625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP095_01625	COG2111	Na H antiporter
NP095_01645	COG0596	Alpha beta hydrolase
NP095_01695	COG2130	NADP-dependent
NP095_01720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP095_01725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP095_01730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP095_01745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP095_01770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP095_01785	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP095_01790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP095_01810	COG0248	Ppx GppA phosphatase
NP095_01815	COG1082	Xylose isomerase domain protein TIM barrel
NP095_01840	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP095_01875	COG2409	Drug exporters of the RND superfamily
NP095_01890	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_01905	COG2755	lipolytic protein G-D-S-L family
NP095_01905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP095_01910	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP095_01915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP095_01925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP095_01925	COG1648	precorrin-2 dehydrogenase activity
NP095_01930	COG0113	porphobilinogen synthase activity
NP095_01935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP095_01940	COG0406	alpha-ribazole phosphatase activity
NP095_01945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP095_01950	COG0785	Cytochrome C biogenesis protein
NP095_01960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP095_01970	COG1131	(ABC) transporter
NP095_01975	COG0842	Transport permease protein
NP095_02005	COG0702	epimerase
NP095_02010	COG4948	Mandelate Racemase Muconate Lactonizing
NP095_02015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP095_02050	COG2226	methyltransferase
NP095_02060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NP095_02065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NP095_02070	COG0649	NAD binding
NP095_02080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NP095_02085	COG1034	ATP synthesis coupled electron transport
NP095_02090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NP095_02095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NP095_02105	COG0713	ATP synthesis coupled electron transport
NP095_02110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP095_02120	COG1007	ATP synthesis coupled electron transport
NP095_02125	COG0142	geranyltranstransferase activity
NP095_02140	COG1666	GTP binding
NP095_02155	COG0463	Glycosyl transferase, family 2
NP095_02160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP095_02170	COG0167	dihydroorotate dehydrogenase activity
NP095_02185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NP095_02190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP095_02200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP095_02210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP095_02220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NP095_02225	COG0081	regulation of translation
NP095_02240	COG0222	ribosome binding
NP095_02245	COG0085	RNA polymerase activity
NP095_02250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP095_02255	COG3594	Acyltransferase
NP095_02270	COG1802	Transcriptional regulator
NP095_02275	COG0277	FAD linked oxidase domain protein
NP095_02275	COG0247	lactate metabolic process
NP095_02285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP095_02290	COG0049	tRNA binding
NP095_02295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP095_02300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP095_02310	COG0051	transcription antitermination factor activity, RNA binding
NP095_02315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP095_02320	COG0088	Forms part of the polypeptide exit tunnel
NP095_02325	COG0089	rRNA binding
NP095_02330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP095_02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NP095_02340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NP095_02345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP095_02350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP095_02355	COG0255	Belongs to the universal ribosomal protein uL29 family
NP095_02360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP095_02365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP095_02370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NP095_02375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP095_02380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP095_02385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP095_02390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP095_02395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP095_02400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP095_02405	COG1841	ribosomal large subunit assembly
NP095_02420	COG0563	adenylate kinase activity
NP095_02435	COG1834	amidinotransferase
NP095_02450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP095_02460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NP095_02465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP095_02470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP095_02475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP095_02480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP095_02485	COG0202	RNA polymerase activity
NP095_02490	COG0203	ribosomal protein L17
NP095_02500	COG1404	Belongs to the peptidase S8 family
NP095_02515	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_02540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP095_02545	COG0444	Belongs to the ABC transporter superfamily
NP095_02555	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_02575	COG1024	Enoyl-CoA hydratase
NP095_02595	COG0183	Belongs to the thiolase family
NP095_02600	COG1024	Enoyl-CoA hydratase
NP095_02610	COG1309	transcriptional regulator
NP095_02620	COG1960	acyl-CoA dehydrogenase activity
NP095_02625	COG1960	acyl-CoA dehydrogenase activity
NP095_02640	COG1793	dna ligase
NP095_02655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP095_02665	COG0494	nUDIX hydrolase
NP095_02670	COG0101	tRNA pseudouridine synthase activity
NP095_02685	COG0183	Belongs to the thiolase family
NP095_02705	COG2070	2-Nitropropane dioxygenase
NP095_02720	COG1024	Enoyl-CoA hydratase
NP095_02755	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NP095_02765	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_02770	COG0300	oxidoreductase activity
NP095_02805	COG1946	Acyl-CoA thioesterase
NP095_02820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP095_02825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP095_02830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP095_02845	COG1072	(Pantothenic acid kinase))
NP095_02850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP095_02860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP095_02870	COG0802	atpase or kinase
NP095_02875	COG0456	acetyltransferase
NP095_02875	COG1214	PFAM Peptidase M22, glycoprotease
NP095_02900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP095_02910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP095_02915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP095_02930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NP095_02935	COG0459	protein refolding
NP095_02965	COG0516	GMP reductase activity
NP095_02970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP095_02980	COG1012	belongs to the aldehyde dehydrogenase family
NP095_02990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP095_03025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP095_03030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP095_03040	COG1129	ABC transporter
NP095_03045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_03065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP095_03070	COG0084	hydrolase, TatD family'
NP095_03085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP095_03090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP095_03095	COG0488	(ABC) transporter
NP095_03100	COG1846	Transcriptional regulator
NP095_03110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NP095_03115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP095_03125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP095_03130	COG0193	aminoacyl-tRNA hydrolase activity
NP095_03140	COG0438	transferase activity, transferring glycosyl groups
NP095_03165	COG0673	inositol 2-dehydrogenase activity
NP095_03230	COG1316	TRANSCRIPTIONal
NP095_03255	COG0148	phosphopyruvate hydratase activity
NP095_03275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP095_03290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP095_03350	COG3663	DNA glycosylase
NP095_03360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP095_03370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP095_03375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP095_03385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP095_03435	COG1331	Highly conserved protein containing a thioredoxin domain
NP095_03445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP095_03450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP095_03460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NP095_03465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP095_03510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP095_03525	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP095_03550	COG0740	serine-type endopeptidase activity
NP095_03555	COG0740	serine-type endopeptidase activity
NP095_03560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP095_03565	COG3268	Saccharopine dehydrogenase
NP095_03570	COG1349	DNA-binding transcription factor activity
NP095_03575	COG0525	valine-tRNA ligase activity
NP095_03585	COG2409	Drug exporters of the RND superfamily
NP095_03590	COG0285	dihydrofolate synthase activity
NP095_03630	COG0366	Alpha amylase catalytic
NP095_03635	COG0105	UTP biosynthetic process
NP095_03655	COG0114	fumarate hydratase activity
NP095_03675	COG1722	exodeoxyribonuclease VII activity
NP095_03680	COG1570	exodeoxyribonuclease VII activity
NP095_03685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP095_03690	COG0405	Gamma-glutamyltransferase
NP095_03705	COG1322	Protein conserved in bacteria
NP095_03730	COG0012	GTP binding
NP095_03760	COG1487	ribonuclease activity
NP095_03765	COG2824	Alkylphosphonate utilization operon protein PhnA
NP095_03770	COG0488	(ABC) transporter
NP095_03785	COG2610	gluconate transmembrane transporter activity
NP095_03815	COG1309	transcriptional regulator
NP095_03825	COG0596	Alpha beta hydrolase
NP095_03850	COG2376	Dihydroxyacetone kinase
NP095_03855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP095_03860	COG0765	amino acid transport
NP095_03865	COG1126	abc transporter atp-binding protein
NP095_03890	COG1309	transcriptional regulator
NP095_03895	COG1742	UPF0060 membrane protein
NP095_03900	COG3012	SEC-C Motif Domain Protein
NP095_03930	COG0385	Bile acid
NP095_03940	COG1309	transcriptional regulator
NP095_03955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP095_03970	COG0454	-acetyltransferase
NP095_03970	COG0456	acetyltransferase
NP095_03990	COG4213	ABC transporter substrate-binding protein
NP095_04000	COG4214	carbohydrate transport
NP095_04020	COG2171	N-acyltransferase activity
NP095_04025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP095_04030	COG1464	Belongs to the NlpA lipoprotein family
NP095_04035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP095_04040	COG2011	ABC-type metal ion transport system permease component
NP095_04090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NP095_04110	COG2301	Belongs to the HpcH HpaI aldolase family
NP095_04120	COG0303	'Molybdopterin
NP095_04130	COG0746	molybdenum cofactor guanylyltransferase activity
NP095_04140	COG1140	nitrate reductase beta subunit
NP095_04160	COG0471	metal ion transport
NP095_04180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP095_04190	COG1846	Transcriptional regulator
NP095_04200	COG1254	Belongs to the acylphosphatase family
NP095_04215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP095_04220	COG0657	acetylesterase activity
NP095_04225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP095_04230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP095_04240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NP095_04270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NP095_04275	COG0745	RESPONSE REGULATOR receiver
NP095_04280	COG5000	phosphorelay sensor kinase activity
NP095_04280	COG5002	protein histidine kinase activity
NP095_04285	COG5401	PFAM Sporulation and spore germination
NP095_04295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP095_04300	COG2197	response regulator
NP095_04305	COG3214	Protein conserved in bacteria
NP095_04310	COG0653	protein targeting
NP095_04325	COG0789	Transcriptional regulator
NP095_04350	COG0489	protein tyrosine kinase activity
NP095_04370	COG1842	Phage shock protein A
NP095_04420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP095_04425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP095_04430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP095_04435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP095_04445	COG1289	transmembrane transporter activity
NP095_04450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP095_04460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP095_04465	COG0799	negative regulation of ribosome biogenesis
NP095_04470	COG0406	alpha-ribazole phosphatase activity
NP095_04485	COG1309	transcriptional regulator
NP095_04495	COG0577	efflux transmembrane transporter activity
NP095_04495	COG1136	(ABC) transporter
NP095_04510	COG0477	Major facilitator Superfamily
NP095_04515	COG3590	peptidase
NP095_04535	COG0564	pseudouridine synthase activity
NP095_04560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP095_04600	COG0778	Nitroreductase
NP095_04620	COG1073	alpha beta
NP095_04645	COG1595	DNA-templated transcription, initiation
NP095_04655	COG3619	membrane
NP095_04675	COG2351	hydroxyisourate hydrolase activity
NP095_04685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP095_04690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP095_04710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NP095_04710	COG2080	2 iron, 2 sulfur cluster binding
NP095_04720	COG0590	tRNA wobble adenosine to inosine editing
NP095_04740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP095_04755	COG0069	glutamate synthase activity
NP095_04795	COG0477	Major facilitator Superfamily
NP095_04815	COG1216	Glycosyl transferase, family 2
NP095_04825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP095_04830	COG0569	domain protein
NP095_04835	COG0495	leucyl-tRNA aminoacylation
NP095_04840	COG1307	EDD domain protein, DegV family
NP095_04845	COG1596	polysaccharide export
NP095_04845	COG1555	photosystem II stabilization
NP095_04860	COG0268	Binds directly to 16S ribosomal RNA
NP095_04870	COG0481	GTPase activity
NP095_04885	COG0584	glycerophosphoryl diester phosphodiesterase
NP095_04890	COG1022	Amp-dependent synthetase and ligase
NP095_04905	COG2235	arginine
NP095_04920	COG1420	regulation of RNA biosynthetic process
NP095_04925	COG0484	heat shock protein binding
NP095_04930	COG0537	adenosine 5'-monophosphoramidase activity
NP095_04940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP095_04955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP095_04960	COG0583	DNA-binding transcription factor activity
NP095_04980	COG0714	Associated with various cellular activities
NP095_04995	COG0435	Glutathione S-transferase
NP095_05000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP095_05020	COG1012	belongs to the aldehyde dehydrogenase family
NP095_05025	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NP095_05030	COG1381	Involved in DNA repair and RecF pathway recombination
NP095_05035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP095_05040	COG0644	oxidoreductase
NP095_05055	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP095_05060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP095_05090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP095_05095	COG0277	FAD linked oxidase domain protein
NP095_05130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP095_05150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP095_05155	COG1414	Transcriptional regulator
NP095_05160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP095_05165	COG0066	3-isopropylmalate dehydratase activity
NP095_05175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP095_05180	COG0626	cystathionine gamma-synthase activity
NP095_05185	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP095_05205	COG0154	amidase activity
NP095_05210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP095_05215	COG1461	Dihydroxyacetone kinase
NP095_05225	COG0742	ribosomal rna small subunit methyltransferase
NP095_05230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP095_05235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP095_05245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NP095_05250	COG0571	ribonuclease III activity
NP095_05255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP095_05260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NP095_05265	COG0358	DNA primase activity
NP095_05290	COG0747	negative chemotaxis
NP095_05315	COG0657	acetylesterase activity
NP095_05340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NP095_05375	COG0741	lytic transglycosylase activity
NP095_05375	COG1196	nuclear chromosome segregation
NP095_05375	COG0739	heme binding
NP095_05395	COG3022	response to hydroperoxide
NP095_05400	COG2119	membrane
NP095_05445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP095_05455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP095_05455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP095_05460	COG0174	glutamine synthetase
NP095_05465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NP095_05500	COG2357	RelA SpoT domain protein
NP095_05505	COG1960	acyl-CoA dehydrogenase activity
NP095_05515	COG2204	response regulator
NP095_05525	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_05540	COG0745	RESPONSE REGULATOR receiver
NP095_05545	COG2205	protein histidine kinase activity
NP095_05585	COG2197	response regulator
NP095_05590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NP095_05595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP095_05595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP095_05620	COG0384	phenazine biosynthesis protein PhzF
NP095_05685	COG0174	glutamine synthetase
NP095_05705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP095_05710	COG2814	Major facilitator Superfamily
NP095_05715	COG0321	lipoyl(octanoyl) transferase activity
NP095_05730	COG1090	epimerase
NP095_05735	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP095_05740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP095_05755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP095_05760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP095_05775	COG1842	Phage shock protein A
NP095_05780	COG0501	Belongs to the peptidase M48B family
NP095_05790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP095_05805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP095_05810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP095_05815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP095_05845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP095_05850	COG0723	plastoquinol--plastocyanin reductase activity
NP095_05855	COG2010	Cytochrome c
NP095_05860	COG1845	cytochrome c oxidase, subunit III
NP095_05870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP095_05890	COG0791	NLP P60 protein
NP095_05895	COG1022	Amp-dependent synthetase and ligase
NP095_05905	COG1940	carbohydrate kinase activity
NP095_05925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NP095_05930	COG2815	serine threonine protein kinase
NP095_05930	COG0515	serine threonine protein kinase
NP095_05935	COG0142	geranyltranstransferase activity
NP095_05950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP095_05960	COG2001	Belongs to the MraZ family
NP095_05965	COG0275	rRNA processing
NP095_05975	COG0768	penicillin binding
NP095_05980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP095_05985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP095_05990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP095_05995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP095_06005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP095_06010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP095_06015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP095_06020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP095_06030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP095_06035	COG1799	cell septum assembly
NP095_06045	COG3599	regulation of cell shape
NP095_06050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP095_06055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP095_06060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP095_06095	COG0587	DNA-directed DNA polymerase activity
NP095_06105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP095_06110	COG3135	benzoate transporter
NP095_06115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP095_06120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP095_06125	COG0131	Imidazoleglycerol-phosphate dehydratase
NP095_06130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP095_06155	COG0107	imidazoleglycerol-phosphate synthase activity
NP095_06165	COG1132	(ABC) transporter
NP095_06170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP095_06200	COG0134	indole-3-glycerol-phosphate synthase activity
NP095_06205	COG0133	tryptophan synthase activity
NP095_06210	COG0159	tryptophan synthase activity
NP095_06215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP095_06220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP095_06225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP095_06230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP095_06250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP095_06260	COG1295	ribonuclease BN
NP095_06275	COG0783	Belongs to the Dps family
NP095_06285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP095_06290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP095_06300	COG1271	oxidase subunit
NP095_06320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP095_06325	COG1074	ATP-dependent DNA helicase activity
NP095_06340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP095_06365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP095_06385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP095_06390	COG2133	pyrroloquinoline quinone binding
NP095_06395	COG1278	Cold shock
NP095_06405	COG0644	oxidoreductase
NP095_06415	COG0343	queuine tRNA-ribosyltransferase activity
NP095_06445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP095_06455	COG0667	Aldo Keto reductase
NP095_06475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP095_06480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP095_06485	COG3253	May function as heme-dependent peroxidase
NP095_06500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP095_06515	COG2326	polyphosphate kinase activity
NP095_06535	COG1960	acyl-CoA dehydrogenase activity
NP095_06565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP095_06585	COG0583	DNA-binding transcription factor activity
NP095_06595	COG2070	2-Nitropropane dioxygenase
NP095_06615	COG0604	alcohol dehydrogenase
NP095_06620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NP095_06625	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_06630	COG1024	Enoyl-CoA hydratase
NP095_06640	COG2149	membrane
NP095_06710	COG1100	Small GTP-binding protein
NP095_06755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NP095_06775	COG0488	(ABC) transporter
NP095_06795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NP095_06800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NP095_06805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NP095_06815	COG0135	phosphoribosylanthranilate isomerase activity
NP095_06820	COG0798	PFAM Bile acid sodium symporter
NP095_06825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP095_06845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP095_06855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP095_06860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP095_06915	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP095_06920	COG0217	transcriptional regulatory protein
NP095_06930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NP095_06935	COG0632	four-way junction helicase activity
NP095_06940	COG2255	four-way junction helicase activity
NP095_06950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP095_06955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP095_06960	COG2827	Endonuclease containing a URI domain
NP095_06965	COG1196	nuclear chromosome segregation
NP095_06975	COG0124	histidyl-tRNA synthetase
NP095_06980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NP095_06985	COG2318	DinB family
NP095_07010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP095_07015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP095_07025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP095_07035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP095_07040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP095_07045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP095_07055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP095_07060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP095_07070	COG2837	iron assimilation
NP095_07085	COG1403	HNH endonuclease
NP095_07125	COG0604	alcohol dehydrogenase
NP095_07130	COG0456	acetyltransferase
NP095_07160	COG0667	Aldo Keto reductase
NP095_07190	COG1595	DNA-templated transcription, initiation
NP095_07200	COG4585	Histidine kinase
NP095_07205	COG2197	response regulator
NP095_07210	COG1131	(ABC) transporter
NP095_07220	COG0121	glutamine amidotransferase
NP095_07245	COG1064	alcohol dehydrogenase
NP095_07250	COG1309	transcriptional regulator
NP095_07265	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP095_07270	COG0540	Belongs to the ATCase OTCase family
NP095_07275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP095_07280	COG0505	Belongs to the CarA family
NP095_07285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP095_07290	COG0284	orotidine-5'-phosphate decarboxylase activity
NP095_07325	COG0194	GDP metabolic process
NP095_07330	COG1758	RNA polymerase activity
NP095_07340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP095_07360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP095_07375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP095_07375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP095_07380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP095_07385	COG0140	phosphoribosyl-ATP diphosphatase activity
NP095_07390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP095_07425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP095_07430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP095_07435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP095_07440	COG5002	protein histidine kinase activity
NP095_07445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP095_07450	COG0072	phenylalanine-tRNA ligase activity
NP095_07450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP095_07460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP095_07470	COG4941	Belongs to the sigma-70 factor family
NP095_07475	COG1403	HNH endonuclease
NP095_07510	COG3304	Inner membrane component domain
NP095_07555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_07575	COG1643	Atp-dependent helicase
NP095_07605	COG0477	Major facilitator Superfamily
NP095_07665	COG2153	protein acetylation
NP095_07680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP095_07685	COG1121	(ABC) transporter
NP095_07690	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP095_07690	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP095_07695	COG0423	glycine-tRNA ligase activity
NP095_07725	COG1196	nuclear chromosome segregation
NP095_07730	COG0824	Thioesterase
NP095_07740	COG1271	oxidase subunit
NP095_07745	COG1294	oxidase, subunit
NP095_07750	COG4988	ABC transporter
NP095_07755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP095_07780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NP095_07790	COG3265	gluconokinase activity
NP095_07810	COG1160	GTP binding
NP095_07815	COG2066	Belongs to the glutaminase family
NP095_07820	COG1403	HNH endonuclease
NP095_07825	COG0039	L-malate dehydrogenase activity
NP095_07840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NP095_07855	COG0531	amino acid
NP095_07860	COG0076	glutamate decarboxylase activity
NP095_07870	COG3467	pyridoxamine 5'-phosphate
NP095_07890	COG2197	response regulator
NP095_07915	COG0515	serine threonine protein kinase
NP095_07915	COG2815	serine threonine protein kinase
NP095_07920	COG0659	secondary active sulfate transmembrane transporter activity
NP095_07935	COG1131	(ABC) transporter
NP095_07945	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NP095_07950	COG0697	spore germination
NP095_07955	COG0739	heme binding
NP095_07995	COG0509	glycine decarboxylation via glycine cleavage system
NP095_08000	COG1716	ATPase activity
NP095_08020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP095_08020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP095_08045	COG1648	precorrin-2 dehydrogenase activity
NP095_08045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP095_08050	COG0175	sulfate reduction
NP095_08060	COG0009	L-threonylcarbamoyladenylate synthase
NP095_08090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP095_08110	COG2936	dipeptidyl-peptidase activity
NP095_08125	COG0640	Transcriptional regulator
NP095_08155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP095_08165	COG4941	Belongs to the sigma-70 factor family
NP095_08170	COG2154	pterin-4-alpha-carbinolamine dehydratase
NP095_08175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP095_08180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_08185	COG3655	Transcriptional regulator
NP095_08220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP095_08225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP095_08245	COG0463	Glycosyl transferase, family 2
NP095_08265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP095_08270	COG4581	dead DEAH box helicase
NP095_08275	COG0805	protein transport
NP095_08290	COG2378	regulation of single-species biofilm formation
NP095_08300	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NP095_08305	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NP095_08310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NP095_08320	COG4122	O-methyltransferase activity
NP095_08330	COG1222	aaa ATPase
NP095_08340	COG0517	IMP dehydrogenase activity
NP095_08340	COG1994	Peptidase M50
NP095_08345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP095_08360	COG0542	response to heat
NP095_08375	COG0515	serine threonine protein kinase
NP095_08375	COG3064	Membrane
NP095_08375	COG4991	sh3 domain protein
NP095_08420	COG0730	response to heat
NP095_08430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP095_08435	COG0477	Major facilitator Superfamily
NP095_08440	COG0646	methionine synthase
NP095_08440	COG1410	methionine synthase
NP095_08450	COG0215	cysteine-tRNA ligase activity
NP095_08455	COG0598	Magnesium transport protein CorA
NP095_08460	COG1968	undecaprenyl-diphosphatase activity
NP095_08465	COG0667	Aldo Keto reductase
NP095_08475	COG1295	ribonuclease BN
NP095_08495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP095_08530	COG1090	epimerase
NP095_08555	COG0559	Belongs to the binding-protein-dependent transport system permease family
NP095_08570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP095_08610	COG2733	membrane
NP095_08625	COG1643	Atp-dependent helicase
NP095_08635	COG0545	Peptidyl-prolyl cis-trans isomerase
NP095_08645	COG1960	acyl-CoA dehydrogenase activity
NP095_08655	COG0242	peptide deformylase activity
NP095_08665	COG1881	PFAM PEBP family protein
NP095_08690	COG1119	ATPase activity
NP095_08695	COG3830	Belongs to the UPF0237 family
NP095_08695	COG0560	Phosphoserine phosphatase
NP095_08700	COG3360	Dodecin
NP095_08720	COG0488	(ABC) transporter
NP095_08725	COG2151	metal-sulfur cluster biosynthetic enzyme
NP095_08730	COG0822	iron-sulfur transferase activity
NP095_08735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP095_08740	COG0396	ATPase activity
NP095_08780	COG1793	dna ligase
NP095_08800	COG0454	-acetyltransferase
NP095_08800	COG0456	acetyltransferase
NP095_08810	COG0109	protoheme IX farnesyltransferase activity
NP095_08820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP095_08825	COG0166	Belongs to the GPI family
NP095_08840	COG0363	glucosamine-6-phosphate deaminase activity
NP095_08850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP095_08855	COG0149	triose-phosphate isomerase activity
NP095_08860	COG0126	phosphoglycerate kinase activity
NP095_08865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP095_08870	COG1481	regulation of sporulation
NP095_08880	COG1660	Displays ATPase and GTPase activities
NP095_08885	COG0322	excinuclease ABC activity
NP095_08890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP095_08900	COG2124	cytochrome p450
NP095_08905	COG0531	amino acid
NP095_08915	COG0556	nucleotide-excision repair
NP095_08935	COG0183	Belongs to the thiolase family
NP095_08950	COG1946	Acyl-CoA thioesterase
NP095_08960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP095_08970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP095_08980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP095_08985	COG0531	amino acid
NP095_08990	COG0569	domain protein
NP095_09015	COG0756	dUTP diphosphatase activity
NP095_09040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP095_09055	COG1435	thymidine kinase activity
NP095_09060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP095_09075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP095_09085	COG0477	Major facilitator Superfamily
NP095_09110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP095_09170	COG0681	Belongs to the peptidase S26 family
NP095_09185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP095_09200	COG0237	dephospho-CoA kinase activity
NP095_09215	COG2207	Transcriptional regulator
NP095_09225	COG0539	negative regulation of cytoplasmic translation
NP095_09235	COG1362	aminopeptidase activity
NP095_09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP095_09245	COG0500	methyltransferase
NP095_09265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NP095_09270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NP095_09285	COG4981	capsule polysaccharide biosynthetic process
NP095_09300	COG0438	transferase activity, transferring glycosyl groups
NP095_09305	COG1215	transferase activity, transferring glycosyl groups
NP095_09325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP095_09325	COG2755	lipolytic protein G-D-S-L family
NP095_09330	COG2755	lipolytic protein G-D-S-L family
NP095_09330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP095_09335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP095_09365	COG0559	Belongs to the binding-protein-dependent transport system permease family
NP095_09400	COG0469	pyruvate kinase activity
NP095_09410	COG0067	glutamate synthase
NP095_09410	COG0069	glutamate synthase activity
NP095_09410	COG0070	glutamate synthase
NP095_09415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP095_09430	COG1126	abc transporter atp-binding protein
NP095_09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP095_09440	COG0765	amino acid transport
NP095_09445	COG0765	amino acid transport
NP095_09450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP095_09460	COG2137	regulation of response to DNA damage stimulus
NP095_09465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP095_09470	COG0693	protein deglycase activity
NP095_09480	COG1396	sequence-specific DNA binding
NP095_09485	COG1058	Belongs to the CinA family
NP095_09485	COG1546	Belongs to the CinA family
NP095_09490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP095_09505	COG1674	ftsk spoiiie
NP095_09515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP095_09520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP095_09540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NP095_09565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP095_09570	COG3842	ATPase activity
NP095_09590	COG1175	transmembrane transport
NP095_09600	COG1185	polyribonucleotide nucleotidyltransferase activity
NP095_09635	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NP095_09645	COG0745	RESPONSE REGULATOR receiver
NP095_09650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP095_09655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP095_09660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP095_09665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP095_09680	COG0779	Required for maturation of 30S ribosomal subunits
NP095_09705	COG0442	prolyl-tRNA aminoacylation
NP095_09720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP095_09725	COG0750	zinc metalloprotease
NP095_09750	COG1131	(ABC) transporter
NP095_09760	COG2197	response regulator
NP095_09765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP095_09780	COG2308	Evidence 4 Homologs of previously reported genes of
NP095_09780	COG2307	Protein conserved in bacteria
NP095_09790	COG0233	cytoplasmic translational termination
NP095_09795	COG0528	UMP kinase activity
NP095_09800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP095_09805	COG0052	Belongs to the universal ribosomal protein uS2 family
NP095_09810	COG1196	nuclear chromosome segregation
NP095_09810	COG0741	lytic transglycosylase activity
NP095_09810	COG0739	heme binding
NP095_09815	COG4974	Belongs to the 'phage' integrase family
NP095_09845	COG0315	cyclic pyranopterin monophosphate synthase activity
NP095_09850	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP095_09870	COG0792	nuclease activity
NP095_09885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP095_09895	COG0681	Belongs to the peptidase S26 family
NP095_09900	COG0335	large ribosomal subunit rRNA binding
NP095_09915	COG0336	Belongs to the RNA methyltransferase TrmD family
NP095_09920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP095_09925	COG1837	Belongs to the UPF0109 family
NP095_09935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP095_09950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP095_09975	COG0494	nUDIX hydrolase
NP095_09980	COG0504	CTP synthase activity
NP095_09995	COG0497	DNA recombination
NP095_10000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP095_10015	COG0647	UMP catabolic process
NP095_10045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP095_10055	COG0589	response to stress
NP095_10070	COG2094	Belongs to the DNA glycosylase MPG family
NP095_10080	COG2755	lipolytic protein G-D-S-L family
NP095_10090	COG0165	Argininosuccinate lyase
NP095_10095	COG1438	arginine binding
NP095_10100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP095_10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP095_10110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NP095_10115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP095_10120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP095_10125	COG0137	argininosuccinate synthase activity
NP095_10135	COG1704	LemA family
NP095_10140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP095_10145	COG0473	3-isopropylmalate dehydrogenase activity
NP095_10170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP095_10175	COG0531	amino acid
NP095_10185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP095_10190	COG0440	acetolactate synthase activity
NP095_10210	COG2755	lipolytic protein G-D-S-L family
NP095_10210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP095_10215	COG0129	dihydroxy-acid dehydratase activity
NP095_10230	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP095_10260	COG1403	HNH endonuclease
NP095_10265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP095_10270	COG0154	amidase activity
NP095_10275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP095_10285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP095_10310	COG0482	sulfurtransferase activity
NP095_10370	COG1674	ftsk spoiiie
NP095_10410	COG1104	cysteine desulfurase activity
NP095_10420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP095_10425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP095_10435	COG0587	DNA-directed DNA polymerase activity
NP095_10465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP095_10470	COG0601	transmembrane transport
NP095_10480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP095_10485	COG2086	electron transfer activity
NP095_10525	COG0183	Belongs to the thiolase family
NP095_10560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP095_10570	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NP095_10585	COG1528	Iron-storage protein
NP095_10595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NP095_10595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NP095_10615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP095_10620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP095_10625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP095_10630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP095_10635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP095_10640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP095_10645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP095_10650	COG0356	it plays a direct role in the translocation of protons across the membrane
NP095_10660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP095_10665	COG0009	L-threonylcarbamoyladenylate synthase
NP095_10675	COG2890	protein-(glutamine-N5) methyltransferase activity
NP095_10680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP095_10685	COG0254	rRNA binding
NP095_10695	COG0386	Belongs to the glutathione peroxidase family
NP095_10705	COG0083	homoserine kinase activity
NP095_10710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP095_10715	COG0460	homoserine dehydrogenase
NP095_10720	COG0569	domain protein
NP095_10720	COG2985	domain, Protein
NP095_10735	COG0018	arginyl-trna synthetase
NP095_10795	COG2226	methyltransferase
NP095_10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP095_10810	COG1764	response to oxidative stress
NP095_10815	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP095_10815	COG0567	Dehydrogenase, E1 component
NP095_10835	COG0604	alcohol dehydrogenase
NP095_10875	COG1595	DNA-templated transcription, initiation
NP095_10880	COG2135	peptidase activity
NP095_10905	COG1162	GTPase activity
NP095_10910	COG0483	inositol monophosphate 1-phosphatase activity
NP095_10915	COG0517	IMP dehydrogenase activity
NP095_10925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP095_10930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP095_10935	COG2340	Cysteine-rich secretory protein family
NP095_10960	COG1960	acyl-CoA dehydrogenase activity
NP095_10990	COG0829	nickel cation binding
NP095_10995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NP095_11015	COG0831	urea catabolic process
NP095_11020	COG0410	ABC transporter
NP095_11035	COG0559	Belongs to the binding-protein-dependent transport system permease family
NP095_11055	COG1132	(ABC) transporter
NP095_11060	COG2860	membrane
NP095_11105	COG1703	isobutyryl-CoA mutase activity
NP095_11105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NP095_11105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NP095_11115	COG0419	ATPase involved in DNA repair
NP095_11145	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_11150	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_11155	COG1960	acyl-CoA dehydrogenase activity
NP095_11175	COG2890	protein-(glutamine-N5) methyltransferase activity
NP095_11180	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_11200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP095_11220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP095_11270	COG1937	Protein conserved in bacteria
NP095_11285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NP095_11300	COG1136	(ABC) transporter
NP095_11305	COG2197	response regulator
NP095_11355	COG1595	DNA-templated transcription, initiation
NP095_11420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NP095_11450	COG0667	Aldo Keto reductase
NP095_11455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_11465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP095_11470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP095_11475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_11480	COG0028	Belongs to the TPP enzyme family
NP095_11510	COG0515	serine threonine protein kinase
NP095_11520	COG1131	(ABC) transporter
NP095_11530	COG0686	Belongs to the AlaDH PNT family
NP095_11555	COG1012	belongs to the aldehyde dehydrogenase family
NP095_11565	COG0028	Belongs to the TPP enzyme family
NP095_11570	COG0442	prolyl-tRNA aminoacylation
NP095_11575	COG1615	UPF0182 protein
NP095_11585	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP095_11615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NP095_11640	COG2816	NAD+ diphosphatase activity
NP095_11645	COG0210	DNA helicase
NP095_11665	COG1309	transcriptional regulator
NP095_11680	COG0513	Belongs to the DEAD box helicase family
NP095_11690	COG1192	Involved in chromosome partitioning
NP095_11725	COG0613	PHP domain protein
NP095_11730	COG0588	phosphoglycerate mutase activity
NP095_11735	COG2030	dehydratase
NP095_11770	COG1960	acyl-CoA dehydrogenase activity
NP095_11780	COG2239	Acts as a magnesium transporter
NP095_11795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP095_11805	COG4122	O-methyltransferase activity
NP095_11830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP095_11840	COG1136	(ABC) transporter
NP095_11840	COG0577	efflux transmembrane transporter activity
NP095_11855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP095_11860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP095_11870	COG1234	tRNA 3'-trailer cleavage
NP095_11875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP095_11880	COG2723	6-phospho-beta-galactosidase activity
NP095_11890	COG1764	response to oxidative stress
NP095_11895	COG1846	Transcriptional regulator
NP095_11900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP095_11925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NP095_11935	COG1335	isochorismatase
NP095_11940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP095_11955	COG0657	acetylesterase activity
NP095_11970	COG1678	Uncharacterized ACR, COG1678
NP095_11985	COG1201	RNA secondary structure unwinding
NP095_11990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP095_12005	COG2072	flavoprotein involved in K transport
NP095_12070	COG1278	Cold shock
NP095_12085	COG1902	pentaerythritol trinitrate reductase activity
NP095_12100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP095_12115	COG2884	Cell division ATP-binding protein ftsE
NP095_12120	COG2837	iron assimilation
NP095_12125	COG2847	Copper chaperone PCu(A)C
NP095_12130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NP095_12135	COG2072	flavoprotein involved in K transport
NP095_12140	COG1920	GTP binding
NP095_12150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP095_12155	COG0778	Nitroreductase
NP095_12155	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NP095_12160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP095_12195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP095_12265	COG0668	transmembrane transport
NP095_12280	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP095_12285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP095_12290	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_12310	COG0736	holo-[acyl-carrier-protein] synthase activity
NP095_12315	COG2030	dehydratase
NP095_12320	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_12325	COG0183	Belongs to the thiolase family
NP095_12330	COG1960	acyl-CoA dehydrogenase activity
NP095_12340	COG2353	YceI-like domain
NP095_12345	COG1846	Transcriptional regulator
NP095_12365	COG2835	tetraacyldisaccharide 4'-kinase activity
NP095_12405	COG1134	teichoic acid transport
NP095_12405	COG1388	LysM domain
NP095_12420	COG1316	TRANSCRIPTIONal
NP095_12450	COG1960	acyl-CoA dehydrogenase activity
NP095_12475	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NP095_12495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP095_12510	COG0424	maF-like protein
NP095_12535	COG1960	acyl-CoA dehydrogenase activity
NP095_12540	COG4770	biotin carboxylase activity
NP095_12550	COG2385	sporulation resulting in formation of a cellular spore
NP095_12560	COG5398	heme oxygenase
NP095_12565	COG1120	ATPase activity
NP095_12570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP095_12575	COG4558	Periplasmic binding protein
NP095_12600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP095_12615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP095_12620	COG1012	belongs to the aldehyde dehydrogenase family
NP095_12625	COG1012	belongs to the aldehyde dehydrogenase family
NP095_12635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP095_12660	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP095_12665	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP095_12670	COG3845	ABC transporter
NP095_12675	COG1744	ABC transporter substrate-binding protein PnrA-like
NP095_12685	COG1473	amidohydrolase
NP095_12685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NP095_12715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP095_12720	COG1053	succinate dehydrogenase
NP095_12730	COG0583	DNA-binding transcription factor activity
NP095_12740	COG0180	Tryptophanyl-tRNA synthetase
NP095_12745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP095_12750	COG0077	Prephenate dehydratase
NP095_12765	COG2838	Isocitrate dehydrogenase
NP095_12770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NP095_12780	COG4208	sulfate ABC transporter
NP095_12790	COG2814	Major facilitator Superfamily
NP095_12800	COG0405	Gamma-glutamyltransferase
NP095_12805	COG0584	glycerophosphoryl diester phosphodiesterase
NP095_12830	COG2197	response regulator
NP095_12850	COG0045	succinate-CoA ligase (ADP-forming) activity
NP095_12875	COG0138	bifunctional purine biosynthesis protein purh
NP095_12890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP095_12910	COG0519	Catalyzes the synthesis of GMP from XMP
NP095_12910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP095_12935	COG1970	mechanosensitive ion channel activity
NP095_12990	COG0259	pyridoxamine-phosphate oxidase activity
NP095_13000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP095_13005	COG2755	lipolytic protein G-D-S-L family
NP095_13005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP095_13010	COG1305	Transglutaminase-like
NP095_13065	COG1278	Cold shock
NP095_13080	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_13085	COG0529	Catalyzes the synthesis of activated sulfate
NP095_13090	COG0730	response to heat
NP095_13095	COG0175	sulfate reduction
NP095_13110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP095_13120	COG0459	protein refolding
NP095_13125	COG1278	Cold shock
NP095_13130	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP095_13155	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NP095_13180	COG2223	nitrite transmembrane transporter activity
NP095_13185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP095_13190	COG0628	permease
NP095_13240	COG0215	cysteine-tRNA ligase activity
NP095_13250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP095_13265	COG1329	Transcriptional regulator
NP095_13280	COG5002	protein histidine kinase activity
NP095_13285	COG0745	RESPONSE REGULATOR receiver
NP095_13290	COG0588	phosphoglycerate mutase activity
NP095_13305	COG0438	transferase activity, transferring glycosyl groups
NP095_13340	COG2211	Major facilitator Superfamily
NP095_13360	COG2409	Drug exporters of the RND superfamily
NP095_13370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP095_13405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP095_13410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP095_13410	COG0463	Glycosyl transferase, family 2
NP095_13415	COG1442	glycosyl transferase family 8
NP095_13415	COG1216	Glycosyl transferase, family 2
NP095_13425	COG0438	transferase activity, transferring glycosyl groups
NP095_13440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP095_13445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP095_13455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP095_13460	COG0302	gtp cyclohydrolase
NP095_13475	COG0037	tRNA processing
NP095_13495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NP095_13510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NP095_13515	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NP095_13520	COG2818	Glycosylase
NP095_13540	COG3845	ABC transporter
NP095_13585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP095_13590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP095_13595	COG1120	ATPase activity
NP095_13615	COG1252	NADH dehydrogenase
NP095_13625	COG0542	response to heat
NP095_13660	COG1063	alcohol dehydrogenase
NP095_13670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP095_13675	COG0438	transferase activity, transferring glycosyl groups
NP095_13685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP095_13685	COG1017	nitric oxide dioxygenase activity
NP095_13735	COG0737	Belongs to the 5'-nucleotidase family
NP095_13755	COG2040	homocysteine
NP095_13760	COG0318	PFAM AMP-dependent synthetase and ligase
NP095_13775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NP095_13795	COG2301	Belongs to the HpcH HpaI aldolase family
NP095_13800	COG1960	acyl-CoA dehydrogenase activity
NP095_13805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NP095_13815	COG2186	Transcriptional regulator
NP095_13825	COG0410	ABC transporter
NP095_13850	COG0154	amidase activity
NP095_13870	COG0484	heat shock protein binding
NP095_13875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP095_13880	COG0443	Heat shock 70 kDa protein
NP095_13885	COG4585	Histidine kinase
NP095_13890	COG2197	response regulator
NP095_13895	COG0577	efflux transmembrane transporter activity
NP095_13895	COG1136	(ABC) transporter
NP095_13915	COG2072	flavoprotein involved in K transport
NP095_13930	COG2409	Drug exporters of the RND superfamily
NP095_13955	COG2252	PERMEase
NP095_13975	COG0154	amidase activity
NP095_13980	COG0024	Methionine aminopeptidase
NP095_13990	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_14005	COG3764	Sortase (surface protein transpeptidase)
NP095_14050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NP095_14055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NP095_14075	COG3845	ABC transporter
NP095_14080	COG4721	ABC-type cobalt transport system, permease component
NP095_14095	COG2271	Major facilitator Superfamily
NP095_14100	COG0247	lactate metabolic process
NP095_14100	COG2181	nitrate reductase activity
NP095_14110	COG1131	(ABC) transporter
NP095_14115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP095_14120	COG2313	pseudouridylate synthase activity
NP095_14130	COG0561	phosphatase activity
NP095_14135	COG0717	Belongs to the dCTP deaminase family
NP095_14155	COG2267	carboxylic ester hydrolase activity
NP095_14170	COG0583	DNA-binding transcription factor activity
NP095_14175	COG1960	acyl-CoA dehydrogenase activity
NP095_14200	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP095_14205	COG0022	dehydrogenase e1 component
NP095_14215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP095_14220	COG0697	spore germination
NP095_14230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP095_14235	COG3001	Fructosamine kinase
NP095_14250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP095_14265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP095_14320	COG1024	Enoyl-CoA hydratase
NP095_14320	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP095_14335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP095_14345	COG1960	acyl-CoA dehydrogenase activity
NP095_14400	COG0657	acetylesterase activity
NP095_14415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NP095_14425	COG0513	Belongs to the DEAD box helicase family
NP095_14435	COG2130	NADP-dependent
NP095_14455	COG3321	synthase
NP095_14455	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_14455	COG0604	alcohol dehydrogenase
NP095_14470	COG1024	Enoyl-CoA hydratase
NP095_14480	COG0778	Nitroreductase
NP095_14495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP095_14495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP095_14495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NP095_14505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP095_14515	COG0702	epimerase
NP095_14520	COG0531	amino acid
NP095_14540	COG0489	protein tyrosine kinase activity
NP095_14565	COG1024	Enoyl-CoA hydratase
NP095_14565	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP095_14570	COG0183	Belongs to the thiolase family
NP095_14600	COG0438	transferase activity, transferring glycosyl groups
NP095_14640	COG0438	transferase activity, transferring glycosyl groups
NP095_14650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP095_14670	COG1960	acyl-CoA dehydrogenase activity
NP095_14680	COG2030	dehydratase
NP095_14685	COG1028	Short-chain dehydrogenase reductase Sdr
NP095_14715	COG0601	transmembrane transport
NP095_14720	COG4608	Belongs to the ABC transporter superfamily
NP095_14725	COG0444	Belongs to the ABC transporter superfamily
NP095_14730	COG0477	Major facilitator Superfamily
NP095_14735	COG1960	acyl-CoA dehydrogenase activity
NP095_14740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NP095_14745	COG2267	carboxylic ester hydrolase activity
NP095_14760	COG0765	amino acid transport
NP095_14765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP095_14785	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP095_14785	COG1902	pentaerythritol trinitrate reductase activity
NP095_14800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP095_14810	COG1937	Protein conserved in bacteria
NP095_14840	COG1132	(ABC) transporter
NP095_14865	COG0586	Pfam SNARE associated Golgi protein
NP095_14875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP095_14885	COG0154	amidase activity
NP095_14895	COG0572	uridine kinase
NP095_14915	COG4585	Histidine kinase
NP095_14930	COG0483	inositol monophosphate 1-phosphatase activity
NP095_14935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP095_14940	COG0352	thiamine-phosphate diphosphorylase activity
NP095_14945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP095_14945	COG0352	thiamine-phosphate diphosphorylase activity
NP095_14945	COG0351	phosphomethylpyrimidine kinase
NP095_15000	COG0305	Participates in initiation and elongation during chromosome replication
NP095_15005	COG0534	Mate efflux family protein
NP095_15010	COG2375	cellular response to nickel ion
NP095_15020	COG0359	binds to the 23S rRNA
NP095_15025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP095_15035	COG0360	Binds together with S18 to 16S ribosomal RNA
NP095_15040	COG1136	(ABC) transporter
NP095_15040	COG0577	efflux transmembrane transporter activity
NP095_15045	COG0577	efflux transmembrane transporter activity
NP095_15045	COG1136	(ABC) transporter
NP095_15050	COG0667	Aldo Keto reductase
NP095_15090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP095_15095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP095_15100	COG1260	myo-inositol-1-phosphate synthase
NP095_15105	COG2354	Protein conserved in bacteria
NP095_15120	COG0410	ABC transporter
NP095_15130	COG1022	Amp-dependent synthetase and ligase
NP095_15150	COG0488	(ABC) transporter
NP095_15175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP095_15175	COG0515	serine threonine protein kinase
NP095_15180	COG0492	ferredoxin-NADP+ reductase activity
NP095_15185	COG3118	belongs to the thioredoxin family
NP095_15195	COG1192	Involved in chromosome partitioning
NP095_15200	COG0357	Ribosomal RNA small subunit methyltransferase G
NP095_15210	COG0706	membrane insertase activity
NP095_15215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP095_15220	COG0594	ribonuclease P activity
NP095_15225	COG0230	Belongs to the bacterial ribosomal protein bL34 family