locus-tag	class	description
I6G90_00005	COG0814	amino acid
I6G90_00010	COG0531	amino acid
I6G90_00015	COG3710	Transcriptional regulator
I6G90_00020	COG0531	amino acid
I6G90_00025	COG1982	Orn Lys Arg decarboxylase major
I6G90_00030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G90_00040	COG3590	peptidase
I6G90_00045	COG0037	tRNA processing
I6G90_00050	COG2203	Gaf domain
I6G90_00050	COG2199	diguanylate cyclase activity
I6G90_00085	COG0366	Alpha amylase catalytic
I6G90_00100	COG0463	Glycosyl transferase, family 2
I6G90_00115	COG2989	Protein conserved in bacteria
I6G90_00120	COG3385	transposase activity
I6G90_00125	COG3108	Peptidase M15
I6G90_00135	COG2860	membrane
I6G90_00145	COG1196	nuclear chromosome segregation
I6G90_00150	COG3115	cell septum assembly
I6G90_00155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G90_00170	COG0602	queuosine metabolic process
I6G90_00205	COG1846	Transcriptional regulator
I6G90_00215	COG0281	malic enzyme
I6G90_00220	COG3290	protein histidine kinase activity
I6G90_00230	COG0697	spore germination
I6G90_00240	COG0346	lactoylglutathione lyase activity
I6G90_00245	COG0745	RESPONSE REGULATOR receiver
I6G90_00250	COG5002	protein histidine kinase activity
I6G90_00275	COG3142	Participates in the control of copper homeostasis
I6G90_00280	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G90_00305	COG0678	peroxiredoxin activity
I6G90_00315	COG0019	diaminopimelate decarboxylase activity
I6G90_00320	COG1115	amino acid carrier protein
I6G90_00325	COG0095	Lipoate-protein ligase
I6G90_00330	COG2233	PERMEase
I6G90_00345	COG0534	Mate efflux family protein
I6G90_00355	COG0281	malic enzyme
I6G90_00385	COG0733	neurotransmitter:sodium symporter activity
I6G90_00390	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G90_00395	COG3706	GGDEF domain
I6G90_00400	COG1566	PFAM secretion protein HlyD family protein
I6G90_00410	COG1032	radical SAM domain protein
I6G90_00435	COG0673	inositol 2-dehydrogenase activity
I6G90_00440	COG2920	part of a sulfur-relay system
I6G90_00445	COG1289	transmembrane transporter activity
I6G90_00450	COG0670	Belongs to the BI1 family
I6G90_00470	COG1486	melibiose metabolic process
I6G90_00475	COG1917	Cupin 2, conserved barrel domain protein
I6G90_00475	COG2169	Transcriptional regulator
I6G90_00480	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G90_00485	COG2723	6-phospho-beta-galactosidase activity
I6G90_00490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G90_00495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G90_00500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G90_00505	COG1446	asparaginase
I6G90_00510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G90_00515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G90_00520	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G90_00535	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6G90_00545	COG3156	type II secretion system protein K
I6G90_00550	COG4795	General secretion pathway protein
I6G90_00555	COG2165	general secretion pathway protein
I6G90_00565	COG2165	general secretion pathway protein
I6G90_00570	COG1459	type II secretion system
I6G90_00575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G90_00595	COG3267	Type II secretory pathway component ExeA
I6G90_00595	COG3409	Peptidoglycan-binding domain 1 protein
I6G90_00600	COG3437	response regulator, receiver
I6G90_00600	COG2770	Histidine kinase
I6G90_00615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G90_00620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G90_00625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_00635	COG2190	(PTS) system
I6G90_00645	COG1196	nuclear chromosome segregation
I6G90_00645	COG3264	Mechanosensitive ion channel
I6G90_00650	COG0469	pyruvate kinase activity
I6G90_00660	COG3384	dioxygenase
I6G90_00670	COG0420	3'-5' exonuclease activity
I6G90_00680	COG2974	May be involved in recombination
I6G90_00690	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G90_00695	COG2190	(PTS) system
I6G90_00695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_00695	COG1263	PTS System
I6G90_00700	COG1609	Transcriptional regulator
I6G90_00710	COG0531	amino acid
I6G90_00715	COG0531	amino acid
I6G90_00730	COG1396	sequence-specific DNA binding
I6G90_00730	COG1917	Cupin 2, conserved barrel domain protein
I6G90_00735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_00780	COG3038	cytochrome b561
I6G90_00785	COG1720	tRNA m6t6A37 methyltransferase activity
I6G90_00805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G90_00810	COG4988	ABC transporter
I6G90_00825	COG0745	RESPONSE REGULATOR receiver
I6G90_00835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G90_00860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G90_00885	COG1988	membrane-bound metal-dependent
I6G90_00895	COG5433	transposase activity
I6G90_00920	COG0159	tryptophan synthase activity
I6G90_00925	COG0133	tryptophan synthase activity
I6G90_00930	COG0135	phosphoribosylanthranilate isomerase activity
I6G90_00930	COG0134	indole-3-glycerol-phosphate synthase activity
I6G90_00940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G90_00950	COG0009	L-threonylcarbamoyladenylate synthase
I6G90_00960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G90_00970	COG0800	Aldolase
I6G90_00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_00980	COG1904	glucuronate isomerase
I6G90_00985	COG0246	Mannitol dehydrogenase
I6G90_00995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G90_01005	COG2186	Transcriptional regulator
I6G90_01010	COG1312	Catalyzes the dehydration of D-mannonate
I6G90_01015	COG1946	Acyl-CoA thioesterase
I6G90_01020	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G90_01025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G90_01035	COG0083	homoserine kinase activity
I6G90_01040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G90_01045	COG0488	(ABC) transporter
I6G90_01060	COG0583	DNA-binding transcription factor activity
I6G90_01075	COG0813	purine-nucleoside phosphorylase activity
I6G90_01090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G90_01110	COG1342	Belongs to the UPF0251 family
I6G90_01125	COG1309	transcriptional regulator
I6G90_01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_01135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G90_01145	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6G90_01190	COG0110	maltose O-acetyltransferase activity
I6G90_01230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G90_01265	COG0577	efflux transmembrane transporter activity
I6G90_01265	COG1136	(ABC) transporter
I6G90_01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_01275	COG1227	inorganic diphosphatase activity
I6G90_01280	COG0497	DNA recombination
I6G90_01285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G90_01290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G90_01295	COG0443	Heat shock 70 kDa protein
I6G90_01300	COG0484	heat shock protein binding
I6G90_01305	COG3385	transposase activity
I6G90_01335	COG1285	pathogenesis
I6G90_01375	COG1566	PFAM secretion protein HlyD family protein
I6G90_01380	COG0577	efflux transmembrane transporter activity
I6G90_01380	COG1136	(ABC) transporter
I6G90_01385	COG1136	(ABC) transporter
I6G90_01385	COG0577	efflux transmembrane transporter activity
I6G90_01390	COG0577	efflux transmembrane transporter activity
I6G90_01390	COG1136	(ABC) transporter
I6G90_01400	COG0095	Lipoate-protein ligase
I6G90_01410	COG0702	epimerase
I6G90_01415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G90_01420	COG1454	alcohol dehydrogenase
I6G90_01430	COG0564	pseudouridine synthase activity
I6G90_01465	COG1280	lysine exporter protein (LysE YggA)
I6G90_01480	COG3263	regulation of cellular component size
I6G90_01485	COG2932	Transcriptional regulator
I6G90_01590	COG0640	Transcriptional regulator
I6G90_01600	COG4373	Mu-like prophage FluMu protein gp28
I6G90_01605	COG4383	Mu-like prophage protein gp29
I6G90_01625	COG4388	Caudovirus prohead serine protease
I6G90_01630	COG4397	Mu-like prophage major head subunit gpT
I6G90_01730	COG1876	peptidase activity
I6G90_01735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G90_01740	COG1393	Belongs to the ArsC family
I6G90_01750	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G90_01755	COG1473	amidohydrolase
I6G90_01765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G90_01775	COG0017	Asparaginyl-tRNA synthetase
I6G90_01790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G90_01795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G90_01800	COG0156	8-amino-7-oxononanoate synthase activity
I6G90_01805	COG2226	methyltransferase
I6G90_01805	COG1073	alpha beta
I6G90_01810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G90_01815	COG0501	Belongs to the peptidase M48B family
I6G90_01825	COG0633	Ferredoxin
I6G90_01825	COG3217	Mosc domain protein beta barrel domain protein
I6G90_01825	COG0633	Ferredoxin
I6G90_01825	COG3217	Mosc domain protein beta barrel domain protein
I6G90_01835	COG0493	'glutamate synthase
I6G90_01840	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G90_01840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G90_01840	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G90_01840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G90_01850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G90_01855	COG1607	acyl-coa hydrolase
I6G90_01865	COG3021	interspecies interaction between organisms
I6G90_01870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G90_01875	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G90_01880	COG1061	Type III restriction enzyme res subunit
I6G90_01885	COG1566	PFAM secretion protein HlyD family protein
I6G90_01895	COG1966	Carbon starvation protein
I6G90_01900	COG3279	Response regulator of the LytR AlgR family
I6G90_01905	COG3275	phosphorelay sensor kinase activity
I6G90_01915	COG2194	sulfuric ester hydrolase activity
I6G90_01920	COG1940	carbohydrate kinase activity
I6G90_01920	COG1846	Transcriptional regulator
I6G90_01925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G90_01930	COG0363	glucosamine-6-phosphate deaminase activity
I6G90_01935	COG2190	(PTS) system
I6G90_01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_01935	COG1263	PTS System
I6G90_01945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G90_01950	COG0735	belongs to the Fur family
I6G90_01960	COG0716	FMN binding
I6G90_01975	COG0596	Alpha beta hydrolase
I6G90_01980	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G90_01985	COG0033	Phosphoglucomutase
I6G90_01990	COG2951	lytic endotransglycosylase activity
I6G90_01995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G90_02000	COG4136	ATPase activity
I6G90_02010	COG4134	Bacterial extracellular solute-binding protein
I6G90_02020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G90_02030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G90_02040	COG0729	surface antigen
I6G90_02045	COG2911	Protein conserved in bacteria
I6G90_02065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G90_02075	COG0741	lytic transglycosylase activity
I6G90_02085	COG4771	TonB-dependent receptor
I6G90_02110	COG1278	Cold shock
I6G90_02125	COG4771	TonB-dependent receptor
I6G90_02160	COG1121	(ABC) transporter
I6G90_02175	COG0583	DNA-binding transcription factor activity
I6G90_02185	COG4166	transmembrane transport
I6G90_02195	COG1349	DNA-binding transcription factor activity
I6G90_02200	COG1882	Formate acetyltransferase
I6G90_02205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G90_02210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G90_02225	COG1187	pseudouridine synthase activity
I6G90_02235	COG4166	transmembrane transport
I6G90_02240	COG0622	Phosphoesterase
I6G90_02255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6G90_02260	COG0784	Response regulator, receiver
I6G90_02260	COG0835	chemotaxis
I6G90_02265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G90_02270	COG1815	bacterial-type flagellum-dependent cell motility
I6G90_02280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6G90_02290	COG4787	bacterial-type flagellum-dependent cell motility
I6G90_02300	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G90_02305	COG1706	bacterial-type flagellum-dependent cell motility
I6G90_02320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G90_02325	COG2239	Acts as a magnesium transporter
I6G90_02335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G90_02340	COG2716	regulation of RNA biosynthetic process
I6G90_02365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G90_02370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G90_02375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G90_02380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G90_02400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G90_02415	COG0590	tRNA wobble adenosine to inosine editing
I6G90_02420	COG0573	inorganic phosphate transmembrane transporter activity
I6G90_02425	COG0581	inorganic phosphate transmembrane transporter activity
I6G90_02430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G90_02435	COG0704	Plays a role in the regulation of phosphate uptake
I6G90_02440	COG1253	flavin adenine dinucleotide binding
I6G90_02455	COG0531	amino acid
I6G90_02470	COG1126	abc transporter atp-binding protein
I6G90_02475	COG0765	amino acid transport
I6G90_02480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_02485	COG3706	GGDEF domain
I6G90_02490	COG2271	Major facilitator Superfamily
I6G90_02500	COG2197	response regulator
I6G90_02505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G90_02525	COG1785	Belongs to the alkaline phosphatase family
I6G90_02530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G90_02535	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G90_02545	COG1199	ATP-dependent helicase activity
I6G90_02555	COG3344	reverse transcriptase
I6G90_02580	COG0346	lactoylglutathione lyase activity
I6G90_02585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G90_02590	COG4660	Part of a membrane complex involved in electron transport
I6G90_02595	COG4659	FMN binding
I6G90_02600	COG4658	electron transport chain
I6G90_02610	COG2878	Part of a membrane complex involved in electron transport
I6G90_02615	COG4657	Part of a membrane complex involved in electron transport
I6G90_02620	COG1061	Type III restriction enzyme res subunit
I6G90_02635	COG1187	pseudouridine synthase activity
I6G90_02640	COG2807	transmembrane transport
I6G90_02665	COG2979	Protein of unknown function (DUF533)
I6G90_02675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G90_02685	COG1294	oxidase, subunit
I6G90_02705	COG3220	belongs to the UPF0276 family
I6G90_02720	COG2814	Major facilitator Superfamily
I6G90_02730	COG0656	L-ascorbic acid biosynthetic process
I6G90_02750	COG0583	DNA-binding transcription factor activity
I6G90_02755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G90_02760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G90_02765	COG2271	Major facilitator Superfamily
I6G90_02770	COG1349	DNA-binding transcription factor activity
I6G90_02780	COG0584	glycerophosphoryl diester phosphodiesterase
I6G90_02785	COG4574	serine-type endopeptidase inhibitor activity
I6G90_02790	COG3085	chromosome segregation
I6G90_02795	COG0583	DNA-binding transcription factor activity
I6G90_02805	COG1448	Aminotransferase
I6G90_02820	COG2333	competence protein COMEC
I6G90_02820	COG0658	competence protein
I6G90_02830	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G90_02835	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G90_02840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G90_02845	COG2197	response regulator
I6G90_02850	COG0322	excinuclease ABC activity
I6G90_02885	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G90_02895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G90_02905	COG1204	response to ionizing radiation
I6G90_02910	COG5433	transposase activity
I6G90_02960	COG2119	membrane
I6G90_02965	COG0023	Translation Initiation Factor
I6G90_02990	COG0513	Belongs to the DEAD box helicase family
I6G90_03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_03005	COG0765	amino acid transport
I6G90_03010	COG1126	abc transporter atp-binding protein
I6G90_03015	COG0493	'glutamate synthase
I6G90_03020	COG0070	glutamate synthase
I6G90_03020	COG0069	glutamate synthase activity
I6G90_03020	COG0067	glutamate synthase
I6G90_03030	COG1242	4 iron, 4 sulfur cluster binding
I6G90_03095	COG3634	alkyl hydroperoxide reductase activity
I6G90_03105	COG0517	IMP dehydrogenase activity
I6G90_03110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G90_03115	COG0343	queuine tRNA-ribosyltransferase activity
I6G90_03120	COG1862	Preprotein translocase
I6G90_03125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G90_03130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G90_03135	COG2897	thiosulfate sulfurtransferase activity
I6G90_03145	COG0826	peptidase U32
I6G90_03150	COG0826	peptidase U32
I6G90_03155	COG3154	lipid carrier protein
I6G90_03170	COG1959	2 iron, 2 sulfur cluster binding
I6G90_03175	COG1104	cysteine desulfurase activity
I6G90_03180	COG0822	iron-sulfur transferase activity
I6G90_03190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G90_03195	COG0443	Heat shock 70 kDa protein
I6G90_03200	COG0633	Ferredoxin
I6G90_03210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G90_03215	COG0105	UTP biosynthetic process
I6G90_03220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G90_03235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G90_03240	COG0124	histidyl-tRNA synthetase
I6G90_03245	COG2976	Protein conserved in bacteria
I6G90_03250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G90_03255	COG1160	GTP binding
I6G90_03260	COG1645	bacterial-type flagellum-dependent swarming motility
I6G90_03265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G90_03270	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G90_03270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G90_03275	COG1007	ATP synthesis coupled electron transport
I6G90_03280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_03290	COG0713	ATP synthesis coupled electron transport
I6G90_03295	COG0839	Belongs to the complex I subunit 6 family
I6G90_03300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_03305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6G90_03310	COG1034	ATP synthesis coupled electron transport
I6G90_03325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_03325	COG0649	NAD binding
I6G90_03330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_03335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_03355	COG1770	oligopeptidase
I6G90_03360	COG4771	TonB-dependent receptor
I6G90_03365	COG1360	Flagellar Motor Protein
I6G90_03370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G90_03385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G90_03395	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6G90_03400	COG4597	amino acid ABC transporter
I6G90_03405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_03410	COG0765	amino acid transport
I6G90_03415	COG1126	abc transporter atp-binding protein
I6G90_03425	COG0724	RNA recognition motif
I6G90_03430	COG4989	oxidoreductase activity
I6G90_03455	COG3437	response regulator, receiver
I6G90_03460	COG0583	DNA-binding transcription factor activity
I6G90_03465	COG5001	Diguanylate cyclase
I6G90_03465	COG3300	MHYT domain
I6G90_03470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6G90_03475	COG0778	Nitroreductase
I6G90_03490	COG2814	Major facilitator Superfamily
I6G90_03505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G90_03510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G90_03515	COG0539	negative regulation of cytoplasmic translation
I6G90_03520	COG0776	regulation of translation
I6G90_03530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G90_03550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G90_03555	COG0602	queuosine metabolic process
I6G90_03560	COG3530	Putative quorum-sensing-regulated virulence factor
I6G90_03565	COG2096	Adenosyltransferase
I6G90_03570	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G90_03575	COG1757	Na H antiporter
I6G90_03580	COG1435	thymidine kinase activity
I6G90_03600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G90_03605	COG0326	Molecular chaperone. Has ATPase activity
I6G90_03610	COG4172	Belongs to the ABC transporter superfamily
I6G90_03615	COG4172	Belongs to the ABC transporter superfamily
I6G90_03625	COG4168	peptide transport system, permease
I6G90_03630	COG0747	negative chemotaxis
I6G90_03635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G90_03640	COG1842	Phage shock protein A
I6G90_03655	COG3106	COG3106 Predicted ATPase
I6G90_03660	COG3768	UPF0283 membrane protein
I6G90_03665	COG0583	DNA-binding transcription factor activity
I6G90_03670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G90_03675	COG3842	ATPase activity
I6G90_03680	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G90_03685	COG1177	transmembrane transport
I6G90_03690	COG1012	belongs to the aldehyde dehydrogenase family
I6G90_03700	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G90_03715	COG2199	diguanylate cyclase activity
I6G90_03720	COG2885	chlorophyll binding
I6G90_03725	COG0861	Integral membrane protein TerC family
I6G90_03740	COG1022	Amp-dependent synthetase and ligase
I6G90_03755	COG2910	NAD(P)H-binding
I6G90_03760	COG0583	DNA-binding transcription factor activity
I6G90_03765	COG0583	DNA-binding transcription factor activity
I6G90_03770	COG0583	DNA-binding transcription factor activity
I6G90_03775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G90_03785	COG0583	DNA-binding transcription factor activity
I6G90_03790	COG2723	6-phospho-beta-galactosidase activity
I6G90_03795	COG1944	ATP diphosphatase activity
I6G90_03800	COG2116	formate transmembrane transporter activity
I6G90_03805	COG1882	Formate acetyltransferase
I6G90_03815	COG1570	exodeoxyribonuclease VII activity
I6G90_03825	COG3088	subunit of a heme lyase
I6G90_03825	COG4235	cytochrome complex assembly
I6G90_03835	COG1138	Cytochrome C-type biogenesis protein
I6G90_03840	COG3301	Polysulphide reductase, NrfD
I6G90_03845	COG0437	4 iron, 4 sulfur cluster binding
I6G90_03850	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6G90_03865	COG0247	lactate metabolic process
I6G90_03870	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6G90_03875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G90_03890	COG1025	Belongs to the peptidase M16 family
I6G90_03895	COG2062	phosphohistidine phosphatase, SixA
I6G90_03905	COG0697	spore germination
I6G90_03915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G90_03920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G90_03930	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G90_03935	COG1136	(ABC) transporter
I6G90_03940	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G90_03945	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G90_03955	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G90_03960	COG0740	serine-type endopeptidase activity
I6G90_03965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G90_03970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G90_03975	COG0776	regulation of translation
I6G90_03980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G90_03990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G90_03995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G90_04000	COG0697	spore germination
I6G90_04005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G90_04040	COG3385	transposase activity
I6G90_04050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G90_04055	COG3099	Belongs to the UPF0263 family
I6G90_04060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G90_04065	COG2894	cell division
I6G90_04070	COG0850	regulation of cytokinetic process
I6G90_04075	COG3100	YcgL domain-containing protein
I6G90_04080	COG1760	l-serine dehydratase
I6G90_04085	COG1760	l-serine dehydratase
I6G90_04090	COG3123	guanosine phosphorylase activity
I6G90_04100	COG0205	6-phosphofructokinase activity
I6G90_04110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G90_04115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G90_04125	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6G90_04130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G90_04135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G90_04150	COG0242	peptide deformylase activity
I6G90_04175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G90_04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G90_04185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G90_04195	COG0549	Belongs to the carbamate kinase family
I6G90_04200	COG0697	spore germination
I6G90_04205	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G90_04205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G90_04210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G90_04215	COG2068	MobA-Related Protein
I6G90_04220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G90_04220	COG0493	'glutamate synthase
I6G90_04225	COG0402	S-adenosylhomocysteine deaminase activity
I6G90_04230	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G90_04235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G90_04235	COG2080	2 iron, 2 sulfur cluster binding
I6G90_04240	COG2233	PERMEase
I6G90_04245	COG0402	S-adenosylhomocysteine deaminase activity
I6G90_04250	COG2252	PERMEase
I6G90_04255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G90_04260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G90_04265	COG2080	2 iron, 2 sulfur cluster binding
I6G90_04270	COG3134	Outer membrane lipoprotein
I6G90_04285	COG5433	transposase activity
I6G90_04295	COG0318	PFAM AMP-dependent synthetase and ligase
I6G90_04300	COG2199	diguanylate cyclase activity
I6G90_04315	COG0107	imidazoleglycerol-phosphate synthase activity
I6G90_04320	COG0784	Response regulator, receiver
I6G90_04320	COG2198	Histidine kinase
I6G90_04320	COG2205	protein histidine kinase activity
I6G90_04325	COG2199	diguanylate cyclase activity
I6G90_04330	COG3437	response regulator, receiver
I6G90_04335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G90_04340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G90_04345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G90_04345	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G90_04350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G90_04355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G90_04360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G90_04370	COG1199	ATP-dependent helicase activity
I6G90_04375	COG1214	PFAM Peptidase M22, glycoprotease
I6G90_04385	COG2267	carboxylic ester hydrolase activity
I6G90_04390	COG0318	PFAM AMP-dependent synthetase and ligase
I6G90_04400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G90_04405	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G90_04410	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G90_04425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G90_04430	COG0840	transmembrane signaling receptor activity
I6G90_04435	COG1254	Belongs to the acylphosphatase family
I6G90_04445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G90_04445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G90_04450	COG0489	protein tyrosine kinase activity
I6G90_04455	COG0572	uridine kinase
I6G90_04460	COG0717	Belongs to the dCTP deaminase family
I6G90_04465	COG0306	phosphate transporter
I6G90_04480	COG0814	amino acid
I6G90_04485	COG0494	nUDIX hydrolase
I6G90_04500	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G90_04520	COG3791	Glutathione-dependent formaldehyde-activating
I6G90_04525	COG0406	alpha-ribazole phosphatase activity
I6G90_04530	COG3706	GGDEF domain
I6G90_04535	COG2840	Smr protein MutS2
I6G90_04540	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G90_04545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G90_04555	COG0513	Belongs to the DEAD box helicase family
I6G90_04560	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G90_04565	COG0814	amino acid
I6G90_04570	COG1609	Transcriptional regulator
I6G90_04575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_04575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_04580	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G90_04585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_04585	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G90_04585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_04590	COG2140	Oxalate decarboxylase
I6G90_04595	COG1609	Transcriptional regulator
I6G90_04610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_04610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_04615	COG3715	PTS system
I6G90_04620	COG3716	PTS system mannose fructose sorbose family IID component
I6G90_04625	COG2942	2-epimerase
I6G90_04630	COG3313	Fe-S protein
I6G90_04635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G90_04640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G90_04645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G90_04650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G90_04660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G90_04670	COG0366	Alpha amylase catalytic
I6G90_04690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G90_04695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G90_04700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G90_04705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G90_04715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G90_04720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G90_04720	COG0072	phenylalanine-tRNA ligase activity
I6G90_04725	COG0776	regulation of translation
I6G90_04730	COG0784	Response regulator, receiver
I6G90_04730	COG2205	protein histidine kinase activity
I6G90_04750	COG1609	Transcriptional regulator
I6G90_04755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_04760	COG1879	ABC-type sugar transport system periplasmic component
I6G90_04765	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G90_04770	COG1129	ABC transporter
I6G90_04775	COG1869	D-ribose catabolic process
I6G90_04780	COG0625	glutathione transferase activity
I6G90_04785	COG5654	RES domain protein
I6G90_04800	COG1177	transmembrane transport
I6G90_04825	COG0037	tRNA processing
I6G90_04830	COG0589	response to stress
I6G90_04835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G90_04850	COG2217	Heavy metal translocating P-type atpase
I6G90_04860	COG2010	Cytochrome c
I6G90_04875	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G90_04885	COG1956	GAF domain-containing protein
I6G90_04890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6G90_04900	COG0308	aminopeptidase N
I6G90_04910	COG2902	Dehydrogenase
I6G90_04915	COG0167	dihydroorotate dehydrogenase activity
I6G90_04925	COG4251	negative regulation of phosphorylation
I6G90_04925	COG3706	GGDEF domain
I6G90_04925	COG2203	Gaf domain
I6G90_04925	COG5001	Diguanylate cyclase
I6G90_04930	COG2201	protein-glutamate methylesterase activity
I6G90_04940	COG0835	chemotaxis
I6G90_04945	COG0840	transmembrane signaling receptor activity
I6G90_04950	COG2198	Histidine kinase
I6G90_04950	COG0643	Histidine kinase
I6G90_04965	COG0116	Belongs to the methyltransferase superfamily
I6G90_04965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G90_04975	COG0488	(ABC) transporter
I6G90_04985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G90_04990	COG1067	ATP-dependent peptidase activity
I6G90_05000	COG4999	Histidine kinase
I6G90_05000	COG2205	protein histidine kinase activity
I6G90_05000	COG3437	response regulator, receiver
I6G90_05000	COG3850	Histidine kinase
I6G90_05040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G90_05045	COG1215	transferase activity, transferring glycosyl groups
I6G90_05050	COG0438	transferase activity, transferring glycosyl groups
I6G90_05065	COG5433	transposase activity
I6G90_05110	COG0438	transferase activity, transferring glycosyl groups
I6G90_05130	COG0438	transferase activity, transferring glycosyl groups
I6G90_05135	COG0438	transferase activity, transferring glycosyl groups
I6G90_05140	COG5499	transcription regulator containing HTH domain
I6G90_05150	COG5642	Protein of unknown function (DUF2384)
I6G90_05215	COG3141	response to X-ray
I6G90_05220	COG0596	Alpha beta hydrolase
I6G90_05225	COG4221	oxidoreductase activity
I6G90_05270	COG0372	Belongs to the citrate synthase family
I6G90_05275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G90_05285	COG2995	paraquat-inducible protein a
I6G90_05290	COG3008	intermembrane lipid transfer
I6G90_05295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G90_05295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G90_05310	COG0084	hydrolase, TatD family'
I6G90_05315	COG0470	DNA polymerase III
I6G90_05320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G90_05325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G90_05330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G90_05335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G90_05340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G90_05345	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_05355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G90_05360	COG0416	fatty acid biosynthetic process
I6G90_05365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G90_05370	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G90_05375	COG0424	maF-like protein
I6G90_05380	COG0583	DNA-binding transcription factor activity
I6G90_05405	COG0564	pseudouridine synthase activity
I6G90_05410	COG1530	ribonuclease E activity
I6G90_05420	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G90_05425	COG0514	ATP-dependent DNA helicase (RecQ)
I6G90_05430	COG2766	serine protein kinase
I6G90_05435	COG2718	Belongs to the UPF0229 family
I6G90_05440	COG2719	SpoVR family
I6G90_05445	COG1024	Enoyl-CoA hydratase
I6G90_05445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G90_05450	COG0183	Belongs to the thiolase family
I6G90_05455	COG0714	Associated with various cellular activities
I6G90_05475	COG2304	oxidoreductase activity
I6G90_05485	COG1595	DNA-templated transcription, initiation
I6G90_05495	COG2067	long-chain fatty acid transport protein
I6G90_05500	COG2067	long-chain fatty acid transport protein
I6G90_05505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6G90_05520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G90_05530	COG1643	Atp-dependent helicase
I6G90_05535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G90_05535	COG0617	tRNA 3'-terminal CCA addition
I6G90_05535	COG0517	IMP dehydrogenase activity
I6G90_05540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G90_05545	COG3119	arylsulfatase activity
I6G90_05550	COG0714	Associated with various cellular activities
I6G90_05565	COG2304	oxidoreductase activity
I6G90_05595	COG0641	radical SAM
I6G90_05600	COG2326	polyphosphate kinase activity
I6G90_05635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G90_05640	COG5433	transposase activity
I6G90_05645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G90_05650	COG3457	Alanine racemase
I6G90_05665	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6G90_05675	COG2188	Transcriptional regulator
I6G90_05680	COG2925	Exonuclease
I6G90_05690	COG3345	alpha-galactosidase
I6G90_05695	COG1380	Effector of murein hydrolase LrgA
I6G90_05700	COG1346	cytolysis
I6G90_05705	COG0295	cytidine deaminase activity
I6G90_05710	COG3033	Beta-eliminating lyase
I6G90_05720	COG3046	protein related to deoxyribodipyrimidine photolyase
I6G90_05725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_05730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G90_05760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G90_05770	COG0454	-acetyltransferase
I6G90_05775	COG3158	transport of potassium into the cell
I6G90_05785	COG0800	Aldolase
I6G90_05790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_05800	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_05815	COG4821	SIS domain
I6G90_05820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6G90_05825	COG4821	SIS domain
I6G90_05830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_05835	COG3716	PTS system mannose fructose sorbose family IID component
I6G90_05840	COG3715	PTS system
I6G90_05850	COG2188	Transcriptional regulator
I6G90_05855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G90_05860	COG0651	ATP synthesis coupled electron transport
I6G90_05865	COG0650	Formate hydrogenlyase subunit 4
I6G90_05870	COG3261	NADH dehydrogenase
I6G90_05870	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G90_05875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G90_05880	COG3260	NADH ubiquinone oxidoreductase 20
I6G90_05890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G90_05900	COG1921	L-seryl-tRNASec selenium transferase activity
I6G90_05910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G90_05915	COG0298	carbon dioxide binding
I6G90_05925	COG0309	Hydrogenase expression formation protein (HypE)
I6G90_05930	COG0375	protein maturation
I6G90_05935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G90_05940	COG1124	(ABC) transporter
I6G90_05950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G90_05955	COG0601	transmembrane transport
I6G90_05965	COG1773	rubredoxin
I6G90_05970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G90_05975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G90_05980	COG5557	Pfam Polysulphide reductase, NrfD
I6G90_05985	COG0437	4 iron, 4 sulfur cluster binding
I6G90_05990	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G90_06005	COG3437	response regulator, receiver
I6G90_06010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G90_06015	COG4251	negative regulation of phosphorylation
I6G90_06015	COG5001	Diguanylate cyclase
I6G90_06015	COG2203	Gaf domain
I6G90_06015	COG3706	GGDEF domain
I6G90_06050	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G90_06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G90_06060	COG0567	Dehydrogenase, E1 component
I6G90_06070	COG1053	succinate dehydrogenase
I6G90_06075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G90_06110	COG1742	UPF0060 membrane protein
I6G90_06135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G90_06150	COG2501	S4 domain
I6G90_06160	COG1132	(ABC) transporter
I6G90_06165	COG1132	(ABC) transporter
I6G90_06175	COG3118	belongs to the thioredoxin family
I6G90_06180	COG0471	metal ion transport
I6G90_06185	COG0058	SHG alpha-glucan phosphorylase activity
I6G90_06200	COG2983	Belongs to the UPF0260 family
I6G90_06215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G90_06220	COG1993	acr, cog1993
I6G90_06260	COG1393	Belongs to the ArsC family
I6G90_06265	COG0798	PFAM Bile acid sodium symporter
I6G90_06280	COG0640	Transcriptional regulator
I6G90_06300	COG0730	response to heat
I6G90_06310	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_06320	COG1024	Enoyl-CoA hydratase
I6G90_06325	COG1024	Enoyl-CoA hydratase
I6G90_06330	COG1960	acyl-CoA dehydrogenase activity
I6G90_06335	COG1960	acyl-CoA dehydrogenase activity
I6G90_06340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G90_06345	COG1024	Enoyl-CoA hydratase
I6G90_06375	COG1584	GPR1 FUN34 yaaH family protein
I6G90_06390	COG1115	amino acid carrier protein
I6G90_06395	COG1024	Enoyl-CoA hydratase
I6G90_06410	COG3162	membrane
I6G90_06415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G90_06420	COG0488	(ABC) transporter
I6G90_06440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_06445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G90_06450	COG0307	riboflavin synthase, alpha
I6G90_06495	COG3829	transcription factor binding
I6G90_06505	COG4681	YaeQ
I6G90_06520	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G90_06525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G90_06530	COG0586	Pfam SNARE associated Golgi protein
I6G90_06540	COG0556	nucleotide-excision repair
I6G90_06555	COG0569	domain protein
I6G90_06555	COG2985	domain, Protein
I6G90_06560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G90_06565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G90_06565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_06580	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G90_06595	COG1451	nucleotide metabolic process
I6G90_06610	COG0417	DNA replication proofreading
I6G90_06620	COG2199	diguanylate cyclase activity
I6G90_06620	COG2203	Gaf domain
I6G90_06635	COG1560	Kdo2-lipid A biosynthetic process
I6G90_06640	COG1560	Kdo2-lipid A biosynthetic process
I6G90_06650	COG0583	DNA-binding transcription factor activity
I6G90_06655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G90_06670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G90_06680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G90_06685	COG2832	Protein of unknown function (DUF454)
I6G90_06690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G90_06705	COG1011	Hydrolase
I6G90_06710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G90_06765	COG3593	DNA synthesis involved in DNA repair
I6G90_06780	COG0583	DNA-binding transcription factor activity
I6G90_06785	COG0730	response to heat
I6G90_06790	COG3148	PFAM DTW domain containing protein
I6G90_06795	COG1940	carbohydrate kinase activity
I6G90_06795	COG1846	Transcriptional regulator
I6G90_06800	COG0840	transmembrane signaling receptor activity
I6G90_06805	COG3012	SEC-C Motif Domain Protein
I6G90_06810	COG0516	GMP reductase activity
I6G90_06810	COG0517	IMP dehydrogenase activity
I6G90_06815	COG0519	Catalyzes the synthesis of GMP from XMP
I6G90_06815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G90_06825	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G90_06835	COG0386	Belongs to the glutathione peroxidase family
I6G90_06840	COG0513	Belongs to the DEAD box helicase family
I6G90_06850	COG0840	transmembrane signaling receptor activity
I6G90_06855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G90_06860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G90_06865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G90_06885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G90_06885	COG0644	oxidoreductase
I6G90_06920	COG3300	MHYT domain
I6G90_06920	COG5001	Diguanylate cyclase
I6G90_06935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_06945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G90_06950	COG0563	adenylate kinase activity
I6G90_06960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G90_06965	COG1286	toxin biosynthetic process
I6G90_06975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G90_06980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G90_06985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G90_06990	COG0531	amino acid
I6G90_06990	COG1674	ftsk spoiiie
I6G90_07000	COG0686	Belongs to the AlaDH PNT family
I6G90_07005	COG0492	ferredoxin-NADP+ reductase activity
I6G90_07010	COG3706	GGDEF domain
I6G90_07015	COG3134	Outer membrane lipoprotein
I6G90_07020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G90_07025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6G90_07030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G90_07035	COG0542	response to heat
I6G90_07040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G90_07045	COG1278	Cold shock
I6G90_07050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G90_07070	COG0745	RESPONSE REGULATOR receiver
I6G90_07075	COG2205	protein histidine kinase activity
I6G90_07085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G90_07085	COG0392	lysyltransferase activity
I6G90_07100	COG0659	secondary active sulfate transmembrane transporter activity
I6G90_07140	COG0672	)-iron permease
I6G90_07160	COG2814	Major facilitator Superfamily
I6G90_07175	COG1136	(ABC) transporter
I6G90_07180	COG0577	efflux transmembrane transporter activity
I6G90_07195	COG0596	Alpha beta hydrolase
I6G90_07215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G90_07220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G90_07220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G90_07225	COG0527	aspartate kinase activity
I6G90_07235	COG1368	sulfuric ester hydrolase activity
I6G90_07240	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G90_07245	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G90_07275	COG0393	Putative heavy-metal-binding
I6G90_07280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G90_07285	COG0285	dihydrofolate synthase activity
I6G90_07290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G90_07295	COG0101	tRNA pseudouridine synthase activity
I6G90_07305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G90_07310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G90_07315	COG0671	phosphoesterase, PA-phosphatase related
I6G90_07320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G90_07325	COG2056	Na+-H+ antiporter family
I6G90_07330	COG0513	Belongs to the DEAD box helicase family
I6G90_07335	COG2050	protein possibly involved in aromatic compounds catabolism
I6G90_07345	COG0247	lactate metabolic process
I6G90_07345	COG0277	FAD linked oxidase domain protein
I6G90_07355	COG1253	flavin adenine dinucleotide binding
I6G90_07360	COG1902	pentaerythritol trinitrate reductase activity
I6G90_07370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G90_07375	COG0647	UMP catabolic process
I6G90_07380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G90_07380	COG4651	solute:proton antiporter activity
I6G90_07390	COG0367	asparagine synthase
I6G90_07395	COG5433	transposase activity
I6G90_07415	COG1216	Glycosyl transferase, family 2
I6G90_07435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G90_07480	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G90_07485	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G90_07495	COG0625	glutathione transferase activity
I6G90_07505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G90_07520	COG0564	pseudouridine synthase activity
I6G90_07525	COG4160	amino acid transport
I6G90_07535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_07545	COG2431	L-lysine efflux transmembrane transporter activity
I6G90_07550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G90_07555	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G90_07565	COG1393	Belongs to the ArsC family
I6G90_07570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G90_07575	COG4783	chaperone-mediated protein folding
I6G90_07580	COG0425	Belongs to the sulfur carrier protein TusA family
I6G90_07605	COG3842	ATPase activity
I6G90_07610	COG3833	ABC-type maltose transport systems, permease component
I6G90_07615	COG1175	transmembrane transport
I6G90_07625	COG3081	Nucleoid-associated protein
I6G90_07630	COG3082	Protein of unknown function (DUF1414)
I6G90_07635	COG3083	sulfuric ester hydrolase activity
I6G90_07640	COG1464	Belongs to the NlpA lipoprotein family
I6G90_07655	COG3385	transposase activity
I6G90_07660	COG0574	Belongs to the PEP-utilizing enzyme family
I6G90_07660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G90_07665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G90_07680	COG3250	beta-galactosidase activity
I6G90_07685	COG0531	amino acid
I6G90_07690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G90_07710	COG5642	Protein of unknown function (DUF2384)
I6G90_07750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G90_07760	COG0714	Associated with various cellular activities
I6G90_07765	COG3318	Belongs to the UPF0149 family
I6G90_07765	COG3012	SEC-C Motif Domain Protein
I6G90_07785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G90_07785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G90_07790	COG0509	glycine decarboxylation via glycine cleavage system
I6G90_07795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G90_07805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G90_07810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G90_07830	COG2814	Major facilitator Superfamily
I6G90_07835	COG0625	glutathione transferase activity
I6G90_07845	COG0483	inositol monophosphate 1-phosphatase activity
I6G90_07855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G90_07870	COG1086	Polysaccharide biosynthesis protein
I6G90_07875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G90_07880	COG1083	cytidylyl-transferase
I6G90_07885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G90_07895	COG2089	acid synthase
I6G90_07950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G90_07960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G90_07965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G90_07985	COG0301	tRNA thio-modification
I6G90_07985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G90_07995	COG4953	penicillin-binding protein 1C
I6G90_08000	COG2373	Large extracellular alpha-helical protein
I6G90_08010	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G90_08015	COG3300	MHYT domain
I6G90_08015	COG5001	Diguanylate cyclase
I6G90_08020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G90_08030	COG1252	NADH dehydrogenase
I6G90_08035	COG3150	esterase
I6G90_08040	COG2233	PERMEase
I6G90_08050	COG2354	Protein conserved in bacteria
I6G90_08065	COG1301	dicarboxylic acid transport
I6G90_08080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G90_08095	COG0537	adenosine 5'-monophosphoramidase activity
I6G90_08130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G90_08135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G90_08145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G90_08150	COG1605	Chorismate mutase
I6G90_08150	COG0287	Prephenate dehydrogenase
I6G90_08160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G90_08165	COG0505	Belongs to the CarA family
I6G90_08175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G90_08185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G90_08190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G90_08195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G90_08200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G90_08205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G90_08210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6G90_08240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G90_08245	COG0861	Integral membrane protein TerC family
I6G90_08260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G90_08265	COG0601	transmembrane transport
I6G90_08275	COG2095	MarC family integral membrane protein
I6G90_08280	COG1012	belongs to the aldehyde dehydrogenase family
I6G90_08280	COG1454	alcohol dehydrogenase
I6G90_08285	COG0217	transcriptional regulatory protein
I6G90_08290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G90_08300	COG1801	Protein of unknown function DUF72
I6G90_08305	COG4106	trans-aconitate 2-methyltransferase activity
I6G90_08310	COG0500	methyltransferase
I6G90_08330	COG0450	alkyl hydroperoxide reductase
I6G90_08335	COG0583	DNA-binding transcription factor activity
I6G90_08340	COG0791	NLP P60 protein
I6G90_08350	COG0583	DNA-binding transcription factor activity
I6G90_08355	COG2610	gluconate transmembrane transporter activity
I6G90_08360	COG3048	D-serine ammonia-lyase activity
I6G90_08370	COG0538	isocitrate dehydrogenase activity
I6G90_08375	COG2207	Transcriptional regulator
I6G90_08385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_08400	COG4521	taurine ABC transporter
I6G90_08405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6G90_08410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G90_08415	COG2175	clavaminate synthase activity
I6G90_08420	COG3152	Membrane
I6G90_08455	COG1309	transcriptional regulator
I6G90_08465	COG1454	alcohol dehydrogenase
I6G90_08485	COG0534	Mate efflux family protein
I6G90_08495	COG2841	Protein conserved in bacteria
I6G90_08505	COG5001	Diguanylate cyclase
I6G90_08505	COG3300	MHYT domain
I6G90_08510	COG3132	Protein of unknown function, DUF480
I6G90_08545	COG0708	Exodeoxyribonuclease III
I6G90_08570	COG1122	ATPase activity
I6G90_08575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_08605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_08610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G90_08620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G90_08625	COG1120	ATPase activity
I6G90_08630	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G90_08635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G90_08640	COG4771	TonB-dependent receptor
I6G90_08645	COG2375	cellular response to nickel ion
I6G90_08660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G90_08665	COG0328	RNA-DNA hybrid ribonuclease activity
I6G90_08670	COG2226	methyltransferase
I6G90_08675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G90_08680	COG1388	LysM domain
I6G90_08680	COG0741	lytic transglycosylase activity
I6G90_08710	COG1376	ErfK ybiS ycfS ynhG family protein
I6G90_08710	COG1388	LysM domain
I6G90_08720	COG0471	metal ion transport
I6G90_08730	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G90_08735	COG0791	NLP P60 protein
I6G90_08755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G90_08760	COG0788	formyltetrahydrofolate deformylase activity
I6G90_08770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G90_08785	COG0739	heme binding
I6G90_08785	COG0741	lytic transglycosylase activity
I6G90_08785	COG1196	nuclear chromosome segregation
I6G90_08790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G90_08800	COG0436	Aminotransferase
I6G90_08805	COG1288	antiporter activity
I6G90_08810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G90_08815	COG1879	ABC-type sugar transport system periplasmic component
I6G90_08825	COG0406	alpha-ribazole phosphatase activity
I6G90_08830	COG2964	Protein conserved in bacteria
I6G90_08835	COG3681	Belongs to the UPF0597 family
I6G90_08840	COG0251	oxidation-reduction process
I6G90_08845	COG0814	amino acid
I6G90_08865	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6G90_08875	COG1166	arginine decarboxylase activity
I6G90_08880	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G90_08895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G90_08905	COG2353	YceI-like domain
I6G90_08910	COG0583	DNA-binding transcription factor activity
I6G90_08920	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G90_08925	COG0840	transmembrane signaling receptor activity
I6G90_08930	COG0302	gtp cyclohydrolase
I6G90_08940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G90_08955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6G90_08975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G90_08980	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G90_08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G90_08990	COG3005	denitrification pathway
I6G90_09000	COG0348	domain, Protein
I6G90_09005	COG0437	4 iron, 4 sulfur cluster binding
I6G90_09010	COG0243	molybdopterin cofactor binding
I6G90_09020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G90_09025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G90_09030	COG3850	Histidine kinase
I6G90_09035	COG2197	response regulator
I6G90_09065	COG0121	glutamine amidotransferase
I6G90_09070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G90_09075	COG1960	acyl-CoA dehydrogenase activity
I6G90_09080	COG1473	amidohydrolase
I6G90_09085	COG2914	Belongs to the UPF0125 (RnfH) family
I6G90_09090	COG2867	negative regulation of translational initiation
I6G90_09095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G90_09105	COG0582	viral genome integration into host DNA
I6G90_09110	COG5642	Protein of unknown function (DUF2384)
I6G90_09165	COG1695	Transcriptional regulator
I6G90_09180	COG4584	PFAM Integrase catalytic
I6G90_09185	COG1484	DNA-dependent DNA replication
I6G90_09190	COG2223	nitrite transmembrane transporter activity
I6G90_09205	COG1609	Transcriptional regulator
I6G90_09260	COG2862	Uncharacterized protein family, UPF0114
I6G90_09275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G90_09280	COG1061	Type III restriction enzyme res subunit
I6G90_09285	COG1002	Type II restriction enzyme, methylase subunits
I6G90_09295	COG1002	Type II restriction enzyme, methylase subunits
I6G90_09305	COG3039	Transposase
I6G90_09320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G90_09335	COG0758	DNA mediated transformation
I6G90_09340	COG0514	ATP-dependent DNA helicase (RecQ)
I6G90_09395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G90_09405	COG1960	acyl-CoA dehydrogenase activity
I6G90_09410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G90_09415	COG1317	bacterial-type flagellum organization
I6G90_09505	COG0457	Tetratricopeptide repeat
I6G90_09580	COG4790	Type iii secretion
I6G90_09585	COG4794	Type iii secretion
I6G90_09590	COG4791	protein targeting
I6G90_09595	COG4792	protein secretion
I6G90_09610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G90_09615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_09615	COG1263	PTS System
I6G90_09620	COG1609	Transcriptional regulator
I6G90_09630	COG4821	SIS domain
I6G90_09650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_09650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_09650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_09670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_09680	COG1187	pseudouridine synthase activity
I6G90_09690	COG0482	sulfurtransferase activity
I6G90_09695	COG2915	High frequency lysogenization protein hflD homolog
I6G90_09700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G90_09705	COG2850	peptidyl-arginine hydroxylation
I6G90_09725	COG0625	glutathione transferase activity
I6G90_09730	COG0259	pyridoxamine-phosphate oxidase activity
I6G90_09735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G90_09735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G90_09740	COG0251	oxidation-reduction process
I6G90_09745	COG1882	Formate acetyltransferase
I6G90_09750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G90_09760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G90_09765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G90_09785	COG4235	cytochrome complex assembly
I6G90_09785	COG3088	subunit of a heme lyase
I6G90_09790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G90_09795	COG1138	Cytochrome C-type biogenesis protein
I6G90_09800	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G90_09805	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G90_09810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G90_09815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G90_09830	COG0835	chemotaxis
I6G90_09840	COG1192	Involved in chromosome partitioning
I6G90_09845	COG1360	Flagellar Motor Protein
I6G90_09850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G90_09855	COG2201	protein-glutamate methylesterase activity
I6G90_09860	COG2198	Histidine kinase
I6G90_09860	COG0643	Histidine kinase
I6G90_09860	COG0784	Response regulator, receiver
I6G90_09865	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G90_09890	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G90_09900	COG1684	flagellar biosynthetic protein fliR
I6G90_09955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G90_09965	COG1677	Flagellar hook-basal body complex protein FliE
I6G90_09980	COG0469	pyruvate kinase activity
I6G90_09985	COG1737	Transcriptional regulator
I6G90_09990	COG0837	glucose binding
I6G90_10020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_10030	COG0281	malic enzyme
I6G90_10055	COG0437	4 iron, 4 sulfur cluster binding
I6G90_10060	COG3383	formate dehydrogenase (NAD+) activity
I6G90_10060	COG3383	formate dehydrogenase (NAD+) activity
I6G90_10095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G90_10105	COG3852	Histidine kinase
I6G90_10110	COG2204	response regulator
I6G90_10120	COG4662	Binding-protein-dependent transport system inner membrane component
I6G90_10130	COG0746	molybdenum cofactor guanylyltransferase activity
I6G90_10135	COG0303	'Molybdopterin
I6G90_10140	COG1289	transmembrane transporter activity
I6G90_10180	COG0784	Response regulator, receiver
I6G90_10180	COG2205	protein histidine kinase activity
I6G90_10195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G90_10200	COG0444	Belongs to the ABC transporter superfamily
I6G90_10205	COG4608	Belongs to the ABC transporter superfamily
I6G90_10215	COG2971	BadF BadG BcrA BcrD
I6G90_10240	COG3724	N-succinylarginine dihydrolase activity
I6G90_10270	COG2197	response regulator
I6G90_10295	COG2199	diguanylate cyclase activity
I6G90_10295	COG2200	EAL domain
I6G90_10295	COG2203	Gaf domain
I6G90_10300	COG0826	peptidase U32
I6G90_10305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G90_10320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G90_10325	COG3706	GGDEF domain
I6G90_10330	COG2211	Major facilitator Superfamily
I6G90_10335	COG0616	signal peptide processing
I6G90_10340	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_10345	COG0583	DNA-binding transcription factor activity
I6G90_10355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G90_10370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G90_10375	COG1881	PFAM PEBP family protein
I6G90_10390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G90_10405	COG1301	dicarboxylic acid transport
I6G90_10410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G90_10415	COG2912	Transglutaminase-like superfamily
I6G90_10425	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G90_10430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G90_10435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G90_10440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G90_10445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G90_10455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G90_10460	COG0737	Belongs to the 5'-nucleotidase family
I6G90_10465	COG0193	aminoacyl-tRNA hydrolase activity
I6G90_10470	COG0012	GTP binding
I6G90_10515	COG0471	metal ion transport
I6G90_10515	COG0490	domain, Protein
I6G90_10525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6G90_10535	COG3097	Belongs to the UPF0267 family
I6G90_10545	COG0366	Alpha amylase catalytic
I6G90_10555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G90_10570	COG1012	belongs to the aldehyde dehydrogenase family
I6G90_10580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G90_10585	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G90_10595	COG0180	Tryptophanyl-tRNA synthetase
I6G90_10605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G90_10610	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G90_10620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G90_10625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G90_10655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G90_10660	COG0583	DNA-binding transcription factor activity
I6G90_10680	COG0583	DNA-binding transcription factor activity
I6G90_10690	COG0739	heme binding
I6G90_10700	COG3264	Mechanosensitive ion channel
I6G90_10700	COG1511	domain protein
I6G90_10705	COG0584	glycerophosphoryl diester phosphodiesterase
I6G90_10715	COG1053	succinate dehydrogenase
I6G90_10720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G90_10725	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G90_10730	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G90_10740	COG3214	Protein conserved in bacteria
I6G90_10745	COG1309	transcriptional regulator
I6G90_10755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_10760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_10775	COG1022	Amp-dependent synthetase and ligase
I6G90_10785	COG4221	oxidoreductase activity
I6G90_10800	COG0642	Histidine kinase
I6G90_10810	COG0516	GMP reductase activity
I6G90_10820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G90_10825	COG3647	Membrane
I6G90_10835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G90_10845	COG0583	DNA-binding transcription factor activity
I6G90_10850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G90_10860	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G90_10880	COG0583	DNA-binding transcription factor activity
I6G90_10885	COG3706	GGDEF domain
I6G90_10895	COG1335	isochorismatase
I6G90_10900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G90_10905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G90_10910	COG1702	phosphate starvation-inducible protein PhoH
I6G90_10915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G90_10925	COG4535	Mg2 and Co2 transporter CorC
I6G90_10930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G90_10945	COG1970	mechanosensitive ion channel activity
I6G90_10950	COG4974	Belongs to the 'phage' integrase family
I6G90_10955	COG0716	FMN binding
I6G90_10965	COG0312	modulator of DNA gyrase
I6G90_10970	COG2888	peptidyl-tyrosine sulfation
I6G90_10975	COG0495	leucyl-tRNA aminoacylation
I6G90_10990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G90_10995	COG0799	negative regulation of ribosome biogenesis
I6G90_11000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G90_11005	COG0768	penicillin binding
I6G90_11010	COG0772	Belongs to the SEDS family
I6G90_11015	COG2951	lytic endotransglycosylase activity
I6G90_11020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G90_11025	COG1686	Belongs to the peptidase S11 family
I6G90_11030	COG2921	Belongs to the UPF0250 family
I6G90_11035	COG0321	lipoyl(octanoyl) transferase activity
I6G90_11040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G90_11060	COG3139	Protein of unknown function (DUF1315)
I6G90_11065	COG0252	asparaginase activity
I6G90_11070	COG0786	glutamate:sodium symporter activity
I6G90_11075	COG5001	Diguanylate cyclase
I6G90_11090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G90_11095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G90_11100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G90_11110	COG1263	PTS System
I6G90_11110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_11120	COG5433	transposase activity
I6G90_11145	COG0366	Alpha amylase catalytic
I6G90_11165	COG0564	pseudouridine synthase activity
I6G90_11170	COG3098	single-species biofilm formation
I6G90_11195	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6G90_11205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G90_11205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G90_11220	COG1611	Belongs to the LOG family
I6G90_11225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G90_11230	COG0473	3-isopropylmalate dehydrogenase activity
I6G90_11240	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6G90_11245	COG2363	Small membrane protein
I6G90_11255	COG0583	DNA-binding transcription factor activity
I6G90_11260	COG0840	transmembrane signaling receptor activity
I6G90_11265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G90_11280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G90_11285	COG1666	GTP binding
I6G90_11295	COG2211	Major facilitator Superfamily
I6G90_11300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G90_11310	COG2813	Specifically methylates the guanine in position
I6G90_11315	COG0271	Belongs to the BolA IbaG family
I6G90_11320	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G90_11325	COG1805	sodium ion transport
I6G90_11330	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G90_11335	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G90_11340	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G90_11345	COG2871	sodium ion transport
I6G90_11350	COG1477	protein flavinylation
I6G90_11380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G90_11395	COG0300	oxidoreductase activity
I6G90_11405	COG0415	Belongs to the DNA photolyase family
I6G90_11410	COG0789	Transcriptional regulator
I6G90_11415	COG3272	Protein of unknown function (DUF1722)
I6G90_11445	COG1605	Chorismate mutase
I6G90_11445	COG0077	Prephenate dehydratase
I6G90_11495	COG4869	propanediol catabolic process
I6G90_11500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6G90_11505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G90_11510	COG1882	Formate acetyltransferase
I6G90_11525	COG1454	alcohol dehydrogenase
I6G90_11525	COG1012	belongs to the aldehyde dehydrogenase family
I6G90_11580	COG0300	oxidoreductase activity
I6G90_11605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G90_11650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_11665	COG0826	peptidase U32
I6G90_11670	COG1280	lysine exporter protein (LysE YggA)
I6G90_11680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G90_11690	COG0745	RESPONSE REGULATOR receiver
I6G90_11700	COG0643	Histidine kinase
I6G90_11700	COG2198	Histidine kinase
I6G90_11710	COG0835	chemotaxis
I6G90_11715	COG0840	transmembrane signaling receptor activity
I6G90_11725	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6G90_11730	COG2201	protein-glutamate methylesterase activity
I6G90_11735	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G90_11740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G90_11745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G90_11750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G90_11755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G90_11760	COG0195	Participates in both transcription termination and antitermination
I6G90_11765	COG0779	Required for maturation of 30S ribosomal subunits
I6G90_11780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G90_11785	COG0149	triose-phosphate isomerase activity
I6G90_11790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G90_11795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G90_11805	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G90_11810	COG1534	Rna-binding protein
I6G90_11825	COG1360	Flagellar Motor Protein
I6G90_11830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G90_11835	COG1722	exodeoxyribonuclease VII activity
I6G90_11840	COG0142	geranyltranstransferase activity
I6G90_11845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G90_11850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_11855	COG0383	alpha-mannosidase activity
I6G90_11860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_11860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_11865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_11865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G90_11865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_11870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G90_11870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_11870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_11890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G90_11905	COG2188	Transcriptional regulator
I6G90_11915	COG4191	Histidine kinase
I6G90_11925	COG2816	NAD+ diphosphatase activity
I6G90_11970	COG1858	cytochrome C peroxidase
I6G90_11975	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6G90_11985	COG2199	diguanylate cyclase activity
I6G90_11985	COG2203	Gaf domain
I6G90_11990	COG0513	Belongs to the DEAD box helicase family
I6G90_12025	COG0154	amidase activity
I6G90_12030	COG2957	Belongs to the agmatine deiminase family
I6G90_12045	COG1902	pentaerythritol trinitrate reductase activity
I6G90_12060	COG1238	metal cluster binding
I6G90_12065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G90_12070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G90_12075	COG0585	pseudouridine synthase activity
I6G90_12085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G90_12090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G90_12095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G90_12105	COG1376	ErfK ybiS ycfS ynhG family protein
I6G90_12110	COG0668	transmembrane transport
I6G90_12120	COG2731	YhcH YjgK YiaL family protein
I6G90_12130	COG1794	racemase activity, acting on amino acids and derivatives
I6G90_12145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G90_12165	COG0488	(ABC) transporter
I6G90_12175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G90_12210	COG0148	phosphopyruvate hydratase activity
I6G90_12215	COG0504	CTP synthase activity
I6G90_12220	COG3956	TIGRFAM MazG family protein
I6G90_12225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G90_12230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G90_12240	COG4807	Protein conserved in bacteria
I6G90_12245	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G90_12250	COG0783	Belongs to the Dps family
I6G90_12255	COG1151	hydroxylamine reductase activity
I6G90_12260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G90_12265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G90_12270	COG0671	phosphoesterase, PA-phosphatase related
I6G90_12275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G90_12280	COG0163	prenyltransferase activity
I6G90_12295	COG1131	(ABC) transporter
I6G90_12300	COG0842	Transport permease protein
I6G90_12305	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6G90_12310	COG1924	4 iron, 4 sulfur cluster binding
I6G90_12325	COG1129	ABC transporter
I6G90_12335	COG1486	melibiose metabolic process
I6G90_12340	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G90_12345	COG2807	transmembrane transport
I6G90_12360	COG1823	symporter activity
I6G90_12370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G90_12375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G90_12380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G90_12385	COG0617	tRNA 3'-terminal CCA addition
I6G90_12390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G90_12395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G90_12400	COG1489	DNA binding
I6G90_12410	COG1643	Atp-dependent helicase
I6G90_12415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G90_12420	COG0346	lactoylglutathione lyase activity
I6G90_12425	COG2076	Multidrug Resistance protein
I6G90_12430	COG2076	Multidrug Resistance protein
I6G90_12435	COG0583	DNA-binding transcription factor activity
I6G90_12440	COG3437	response regulator, receiver
I6G90_12440	COG0784	Response regulator, receiver
I6G90_12445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G90_12460	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G90_12475	COG1136	(ABC) transporter
I6G90_12495	COG0840	transmembrane signaling receptor activity
I6G90_12505	COG0529	Catalyzes the synthesis of activated sulfate
I6G90_12510	COG3273	potassium ion transport
I6G90_12510	COG0471	metal ion transport
I6G90_12515	COG2895	sulfate adenylyltransferase (ATP) activity
I6G90_12520	COG0175	sulfate reduction
I6G90_12525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G90_12525	COG1648	precorrin-2 dehydrogenase activity
I6G90_12530	COG0330	HflC and HflK could
I6G90_12535	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G90_12540	COG0840	transmembrane signaling receptor activity
I6G90_12545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G90_12550	COG0676	glucose-6-phosphate 1-epimerase activity
I6G90_12555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G90_12560	COG1640	4-alpha-glucanotransferase
I6G90_12565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G90_12615	COG0561	phosphatase activity
I6G90_12630	COG0733	neurotransmitter:sodium symporter activity
I6G90_12640	COG0733	neurotransmitter:sodium symporter activity
I6G90_12705	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G90_12710	COG2885	chlorophyll binding
I6G90_12715	COG0823	Involved in the tonB-independent uptake of proteins
I6G90_12730	COG0811	peptide transport
I6G90_12735	COG0824	Thioesterase
I6G90_12740	COG3790	cyd operon protein YbgE
I6G90_12745	COG4890	Cyd operon protein YbgT
I6G90_12750	COG1294	oxidase, subunit
I6G90_12760	COG2255	four-way junction helicase activity
I6G90_12765	COG0632	four-way junction helicase activity
I6G90_12785	COG2771	luxR family
I6G90_12790	COG3916	Acyl-homoserine-lactone synthase
I6G90_12800	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6G90_12805	COG2203	Gaf domain
I6G90_12805	COG5001	Diguanylate cyclase
I6G90_12805	COG4251	negative regulation of phosphorylation
I6G90_12805	COG3706	GGDEF domain
I6G90_12815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G90_12825	COG2995	paraquat-inducible protein a
I6G90_12830	COG3008	intermembrane lipid transfer
I6G90_12830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G90_12840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G90_12845	COG0442	prolyl-tRNA aminoacylation
I6G90_12850	COG4221	oxidoreductase activity
I6G90_12865	COG1024	Enoyl-CoA hydratase
I6G90_12875	COG0110	maltose O-acetyltransferase activity
I6G90_12885	COG4166	transmembrane transport
I6G90_12895	COG0840	transmembrane signaling receptor activity
I6G90_12900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G90_12905	COG0735	belongs to the Fur family
I6G90_12930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G90_12935	COG0513	Belongs to the DEAD box helicase family
I6G90_12940	COG2153	protein acetylation
I6G90_12950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G90_12955	COG0557	exoribonuclease II activity
I6G90_12960	COG3706	GGDEF domain
I6G90_12970	COG3240	lipase activity
I6G90_12975	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G90_12985	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G90_12990	COG1194	a g-specific adenine glycosylase
I6G90_12995	COG0617	tRNA 3'-terminal CCA addition
I6G90_13015	COG3068	Protein conserved in bacteria
I6G90_13025	COG0739	heme binding
I6G90_13045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G90_13050	COG1121	(ABC) transporter
I6G90_13055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G90_13060	COG0583	DNA-binding transcription factor activity
I6G90_13070	COG1573	uracil-dna glycosylase
I6G90_13085	COG2827	Endonuclease containing a URI domain
I6G90_13100	COG1842	Phage shock protein A
I6G90_13105	COG0204	Acyl-transferase
I6G90_13125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G90_13130	COG0484	heat shock protein binding
I6G90_13165	COG0326	Molecular chaperone. Has ATPase activity
I6G90_13180	COG3150	esterase
I6G90_13190	COG3151	Protein conserved in bacteria
I6G90_13195	COG0494	nUDIX hydrolase
I6G90_13200	COG1538	Outer membrane efflux protein
I6G90_13205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G90_13205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G90_13210	COG1560	Kdo2-lipid A biosynthetic process
I6G90_13215	COG2213	PTS system mannitol-specific
I6G90_13215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_13220	COG0246	Mannitol dehydrogenase
I6G90_13225	COG3722	fumarate hydratase activity
I6G90_13255	COG1671	Belongs to the UPF0178 family
I6G90_13260	COG1988	membrane-bound metal-dependent
I6G90_13265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G90_13270	COG0513	Belongs to the DEAD box helicase family
I6G90_13290	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G90_13295	COG1169	isochorismate synthase
I6G90_13300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G90_13315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G90_13320	COG1441	menaquinone biosynthetic process
I6G90_13325	COG0318	PFAM AMP-dependent synthetase and ligase
I6G90_13330	COG3291	Pkd domain containing protein
I6G90_13335	COG2949	membrane
I6G90_13340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G90_13350	COG0835	chemotaxis
I6G90_13350	COG0784	Response regulator, receiver
I6G90_13360	COG1444	tRNA N-acetyltransferase activity
I6G90_13380	COG1803	Methylglyoxal synthase
I6G90_13385	COG1979	alcohol dehydrogenase
I6G90_13405	COG4221	oxidoreductase activity
I6G90_13440	COG1368	sulfuric ester hydrolase activity
I6G90_13445	COG1522	sequence-specific DNA binding
I6G90_13455	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G90_13465	COG1546	Belongs to the CinA family
I6G90_13465	COG1058	Belongs to the CinA family
I6G90_13475	COG0561	phosphatase activity
I6G90_13485	COG2926	Belongs to the UPF0265 family
I6G90_13520	COG1396	sequence-specific DNA binding
I6G90_13525	COG3135	benzoate transporter
I6G90_13550	COG0840	transmembrane signaling receptor activity
I6G90_13555	COG3047	cAMP biosynthetic process
I6G90_13565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G90_13580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G90_13590	COG1278	Cold shock
I6G90_13595	COG2252	PERMEase
I6G90_13600	COG2376	Dihydroxyacetone kinase
I6G90_13605	COG1461	Dihydroxyacetone kinase
I6G90_13620	COG3284	Transcriptional regulator
I6G90_13625	COG0583	DNA-binding transcription factor activity
I6G90_13630	COG2957	Belongs to the agmatine deiminase family
I6G90_13635	COG0628	permease
I6G90_13640	COG0671	phosphoesterase, PA-phosphatase related
I6G90_13655	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G90_13660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G90_13680	COG0456	acetyltransferase
I6G90_13685	COG3133	Outer membrane lipoprotein
I6G90_13690	COG3385	transposase activity
I6G90_13695	COG0004	ammonium transporteR
I6G90_13700	COG3706	GGDEF domain
I6G90_13710	COG3932	Exopolysaccharide synthesis, ExoD
I6G90_13715	COG0814	amino acid
I6G90_13730	COG0110	maltose O-acetyltransferase activity
I6G90_13735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G90_13745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G90_13750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G90_13760	COG0137	argininosuccinate synthase activity
I6G90_13765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G90_13770	COG0165	Argininosuccinate lyase
I6G90_13795	COG3314	Sporulation integral membrane protein YlbJ
I6G90_13820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G90_13825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G90_13840	COG0477	Major facilitator Superfamily
I6G90_13845	COG0523	cobalamin synthesis protein
I6G90_13855	COG1280	lysine exporter protein (LysE YggA)
I6G90_13870	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_13875	COG2200	EAL domain
I6G90_13880	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6G90_13885	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G90_13890	COG0840	transmembrane signaling receptor activity
I6G90_13900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G90_13905	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G90_13910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G90_13915	COG2186	Transcriptional regulator
I6G90_13940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G90_13945	COG1459	type II secretion system
I6G90_13960	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6G90_13965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G90_13970	COG0494	nUDIX hydrolase
I6G90_13975	COG0653	protein targeting
I6G90_13985	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6G90_13990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G90_13995	COG0849	cell division
I6G90_14005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G90_14010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G90_14015	COG0772	Belongs to the SEDS family
I6G90_14020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G90_14025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G90_14030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G90_14040	COG0768	penicillin binding
I6G90_14045	COG3116	cell division
I6G90_14050	COG0275	rRNA processing
I6G90_14055	COG2001	Belongs to the MraZ family
I6G90_14065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G90_14070	COG3107	peptidoglycan biosynthetic process
I6G90_14075	COG0792	nuclease activity
I6G90_14080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G90_14090	COG2969	positive regulation of protein catabolic process
I6G90_14095	COG0625	glutathione transferase activity
I6G90_14100	COG2857	Cytochrome c1
I6G90_14105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G90_14110	COG0723	plastoquinol--plastocyanin reductase activity
I6G90_14115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G90_14120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G90_14125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G90_14135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G90_14140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G90_14145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_14150	COG1660	Displays ATPase and GTPase activities
I6G90_14155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_14165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G90_14170	COG1137	ATPase activity
I6G90_14175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G90_14180	COG3117	lipopolysaccharide transmembrane transporter activity
I6G90_14185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G90_14190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G90_14190	COG0517	IMP dehydrogenase activity
I6G90_14195	COG1127	ABC transporter
I6G90_14200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G90_14205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G90_14210	COG2854	intermembrane phospholipid transfer
I6G90_14220	COG5007	Belongs to the BolA IbaG family
I6G90_14225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G90_14230	COG0312	modulator of DNA gyrase
I6G90_14235	COG3028	Belongs to the UPF0307 family
I6G90_14240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G90_14260	COG1011	Hydrolase
I6G90_14275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G90_14280	COG0019	diaminopimelate decarboxylase activity
I6G90_14290	COG1965	Belongs to the frataxin family
I6G90_14295	COG0400	carboxylic ester hydrolase activity
I6G90_14300	COG3072	Adenylate cyclase
I6G90_14305	COG0181	hydroxymethylbilane synthase activity
I6G90_14315	COG2959	enzyme of heme biosynthesis
I6G90_14330	COG1494	fructose-1,6-bisphosphatase
I6G90_14385	COG0795	lipopolysaccharide-transporting ATPase activity
I6G90_14390	COG0795	lipopolysaccharide-transporting ATPase activity
I6G90_14395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G90_14400	COG2927	DNA polymerase III (CHI subunit)
I6G90_14425	COG0456	acetyltransferase
I6G90_14425	COG0454	-acetyltransferase
I6G90_14430	COG0753	catalase activity
I6G90_14455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G90_14460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6G90_14465	COG5380	lipid catabolic process
I6G90_14485	COG4533	DNA binding
I6G90_14495	COG2873	o-acetylhomoserine
I6G90_14525	COG3842	ATPase activity
I6G90_14535	COG1175	transmembrane transport
I6G90_14560	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G90_14585	COG5433	transposase activity
I6G90_14590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G90_14595	COG1074	ATP-dependent DNA helicase activity
I6G90_14600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G90_14605	COG2259	Doxx family
I6G90_14610	COG1741	Belongs to the pirin family
I6G90_14620	COG0583	DNA-binding transcription factor activity
I6G90_14635	COG3385	transposase activity
I6G90_14655	COG3706	GGDEF domain
I6G90_14695	COG0203	ribosomal protein L17
I6G90_14700	COG0202	RNA polymerase activity
I6G90_14705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G90_14710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G90_14715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G90_14720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G90_14725	COG0201	protein transport
I6G90_14730	COG0200	Binds to the 23S rRNA
I6G90_14735	COG1841	ribosomal large subunit assembly
I6G90_14740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G90_14745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G90_14750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G90_14755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G90_14760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G90_14765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G90_14770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G90_14775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G90_14780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G90_14785	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G90_14790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G90_14795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G90_14800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G90_14805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G90_14810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G90_14815	COG0089	rRNA binding
I6G90_14820	COG0088	Forms part of the polypeptide exit tunnel
I6G90_14825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G90_14830	COG0051	transcription antitermination factor activity, RNA binding
I6G90_14850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G90_14855	COG2183	response to ionizing radiation
I6G90_14875	COG0596	Alpha beta hydrolase
I6G90_14880	COG1040	competence protein
I6G90_14885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G90_14885	COG0316	Belongs to the HesB IscA family
I6G90_14890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G90_14895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G90_14900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G90_14905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G90_14910	COG4942	peptidase
I6G90_14920	COG1609	Transcriptional regulator
I6G90_14925	COG0800	Aldolase
I6G90_14935	COG3265	gluconokinase activity
I6G90_14940	COG2610	gluconate transmembrane transporter activity
I6G90_14945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G90_14950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G90_14960	COG0456	acetyltransferase
I6G90_14970	COG1490	D-aminoacyl-tRNA deacylase activity
I6G90_14975	COG1295	ribonuclease BN
I6G90_14980	COG0281	malic enzyme
I6G90_14985	COG0814	amino acid
I6G90_14990	COG0702	epimerase
I6G90_15000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G90_15005	COG0254	rRNA binding
I6G90_15020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G90_15025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G90_15035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G90_15045	COG0514	ATP-dependent DNA helicase (RecQ)
I6G90_15050	COG2050	protein possibly involved in aromatic compounds catabolism
I6G90_15065	COG2258	MOSC domain
I6G90_15070	COG1177	transmembrane transport
I6G90_15075	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G90_15080	COG3842	ATPase activity
I6G90_15100	COG0174	glutamine synthetase
I6G90_15120	COG3045	CreA protein
I6G90_15125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G90_15130	COG0443	Heat shock 70 kDa protein
I6G90_15145	COG0366	Alpha amylase catalytic
I6G90_15160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G90_15170	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6G90_15185	COG3250	beta-galactosidase activity
I6G90_15190	COG1609	Transcriptional regulator
I6G90_15195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G90_15200	COG1085	galactose-1-phosphate uridylyltransferase
I6G90_15205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G90_15210	COG2017	converts alpha-aldose to the beta-anomer
I6G90_15215	COG1968	undecaprenyl-diphosphatase activity
I6G90_15225	COG1595	DNA-templated transcription, initiation
I6G90_15235	COG0018	arginyl-trna synthetase
I6G90_15245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G90_15250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G90_15260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_15265	COG1131	(ABC) transporter
I6G90_15270	COG0842	Transport permease protein
I6G90_15275	COG0842	Transport permease protein
I6G90_15280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G90_15290	COG2116	formate transmembrane transporter activity
I6G90_15295	COG1648	precorrin-2 dehydrogenase activity
I6G90_15295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G90_15300	COG2239	Acts as a magnesium transporter
I6G90_15305	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G90_15310	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G90_15315	COG3845	ABC transporter
I6G90_15320	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G90_15335	COG0210	DNA helicase
I6G90_15375	COG1280	lysine exporter protein (LysE YggA)
I6G90_15405	COG1216	Glycosyl transferase, family 2
I6G90_15420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G90_15435	COG1063	alcohol dehydrogenase
I6G90_15440	COG3245	cytochrome
I6G90_15455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G90_15460	COG2166	iron-sulfur cluster assembly
I6G90_15465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G90_15500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G90_15510	COG0583	DNA-binding transcription factor activity
I6G90_15525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G90_15530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G90_15535	COG2223	nitrite transmembrane transporter activity
I6G90_15540	COG3279	Response regulator of the LytR AlgR family
I6G90_15545	COG3275	phosphorelay sensor kinase activity
I6G90_15550	COG2081	HI0933 family
I6G90_15555	COG1528	Iron-storage protein
I6G90_15560	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G90_15565	COG0589	response to stress
I6G90_15605	COG3642	lipopolysaccharide core region biosynthetic process
I6G90_15610	COG0859	PFAM glycosyl transferase family 9
I6G90_15615	COG0194	GDP metabolic process
I6G90_15620	COG1758	RNA polymerase activity
I6G90_15625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G90_15630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G90_15640	COG2267	carboxylic ester hydrolase activity
I6G90_15645	COG0561	phosphatase activity
I6G90_15670	COG2271	Major facilitator Superfamily
I6G90_15675	COG0469	pyruvate kinase activity
I6G90_15705	COG1309	transcriptional regulator
I6G90_15710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_15715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G90_15720	COG4191	Histidine kinase
I6G90_15720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_15725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G90_15735	COG0604	alcohol dehydrogenase
I6G90_15740	COG2267	carboxylic ester hydrolase activity
I6G90_15745	COG1733	regulation of RNA biosynthetic process
I6G90_15765	COG2205	protein histidine kinase activity
I6G90_15770	COG0745	RESPONSE REGULATOR receiver
I6G90_15775	COG2814	Major facilitator Superfamily
I6G90_15790	COG3977	Valine--pyruvate aminotransferase
I6G90_15795	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G90_15800	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G90_15805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G90_15820	COG0187	DNA topoisomerase II activity
I6G90_15830	COG0592	DNA-directed DNA polymerase activity
I6G90_15835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G90_15850	COG1126	abc transporter atp-binding protein
I6G90_15855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G90_15860	COG0594	ribonuclease P activity
I6G90_15865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G90_15870	COG0706	membrane insertase activity
I6G90_15875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G90_15885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G90_15890	COG1120	ATPase activity
I6G90_15895	COG4615	Cyclic peptide transporter
I6G90_15900	COG4774	siderophore transport
I6G90_15905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G90_15910	COG0445	tRNA wobble uridine modification
I6G90_15915	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G90_15920	COG1192	Involved in chromosome partitioning
I6G90_15925	COG1475	DNA binding
I6G90_15935	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G90_15945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G90_15950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G90_15955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G90_15960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G90_15965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G90_15970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G90_15975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G90_15980	COG4452	Inner membrane protein CreD
I6G90_15995	COG2205	protein histidine kinase activity
I6G90_16000	COG0745	RESPONSE REGULATOR receiver
I6G90_16005	COG1349	DNA-binding transcription factor activity
I6G90_16010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G90_16015	COG2771	luxR family
I6G90_16025	COG0811	peptide transport
I6G90_16030	COG0811	peptide transport
I6G90_16035	COG0848	biopolymer transport protein
I6G90_16040	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6G90_16075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G90_16080	COG0402	S-adenosylhomocysteine deaminase activity
I6G90_16085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G90_16090	COG2226	methyltransferase
I6G90_16095	COG3165	ubiquinone biosynthetic process from chorismate
I6G90_16100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G90_16105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G90_16110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G90_16115	COG0805	protein transport
I6G90_16120	COG0084	hydrolase, TatD family'
I6G90_16130	COG3469	chitinase activity
I6G90_16145	COG0742	ribosomal rna small subunit methyltransferase
I6G90_16155	COG0248	Ppx GppA phosphatase
I6G90_16160	COG0513	Belongs to the DEAD box helicase family
I6G90_16165	COG3118	belongs to the thioredoxin family
I6G90_16180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G90_16190	COG5001	Diguanylate cyclase
I6G90_16190	COG5002	protein histidine kinase activity
I6G90_16195	COG2960	long-chain fatty acid transporting porin activity
I6G90_16200	COG3385	transposase activity
I6G90_16210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G90_16240	COG1609	Transcriptional regulator
I6G90_16280	COG0751	glycine-tRNA ligase activity
I6G90_16285	COG0752	glycyl-tRNA synthetase alpha subunit
I6G90_16290	COG2818	Glycosylase
I6G90_16305	COG2885	chlorophyll binding
I6G90_16315	COG0251	oxidation-reduction process
I6G90_16320	COG0425	Belongs to the sulfur carrier protein TusA family
I6G90_16345	COG0183	Belongs to the thiolase family
I6G90_16350	COG1024	Enoyl-CoA hydratase
I6G90_16350	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G90_16355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G90_16360	COG0006	proline dipeptidase activity
I6G90_16365	COG1739	Uncharacterized protein family UPF0029
I6G90_16370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G90_16375	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6G90_16405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G90_16405	COG1042	CoA-binding domain protein
I6G90_16405	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G90_16425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G90_16430	COG0166	Belongs to the GPI family
I6G90_16435	COG0668	transmembrane transport
I6G90_16440	COG1309	transcriptional regulator
I6G90_16445	COG0756	dUTP diphosphatase activity
I6G90_16450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G90_16455	COG2003	Belongs to the UPF0758 family
I6G90_16460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G90_16465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G90_16475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G90_16480	COG2990	Protein conserved in bacteria
I6G90_16485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G90_16490	COG0859	PFAM glycosyl transferase family 9
I6G90_16495	COG0463	Glycosyl transferase, family 2
I6G90_16500	COG0859	PFAM glycosyl transferase family 9
I6G90_16505	COG1519	Transferase
I6G90_16520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G90_16525	COG1609	Transcriptional regulator
I6G90_16530	COG0604	alcohol dehydrogenase
I6G90_16550	COG3161	chorismate lyase activity
I6G90_16555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G90_16560	COG2937	Belongs to the GPAT DAPAT family
I6G90_16565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G90_16580	COG0534	Mate efflux family protein
I6G90_16585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G90_16590	COG2205	protein histidine kinase activity
I6G90_16595	COG0745	RESPONSE REGULATOR receiver
I6G90_16605	COG1045	serine acetyltransferase
I6G90_16615	COG3074	FtsZ-dependent cytokinesis
I6G90_16620	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G90_16625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G90_16625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G90_16630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G90_16670	COG1609	Transcriptional regulator
I6G90_16675	COG3250	beta-galactosidase activity
I6G90_16680	COG2731	YhcH YjgK YiaL family protein
I6G90_16685	COG0531	amino acid
I6G90_16690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G90_16695	COG0531	amino acid
I6G90_16700	COG0385	Bile acid
I6G90_16705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G90_16725	COG0583	DNA-binding transcription factor activity
I6G90_16730	COG1561	YicC-like family, N-terminal region
I6G90_16740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G90_16755	COG2203	Gaf domain
I6G90_16755	COG4251	negative regulation of phosphorylation
I6G90_16755	COG5001	Diguanylate cyclase
I6G90_16755	COG3706	GGDEF domain
I6G90_16760	COG3084	Protein conserved in bacteria
I6G90_16770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G90_16775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G90_16785	COG1335	isochorismatase
I6G90_16795	COG1683	Conserved Protein
I6G90_16800	COG0204	Acyl-transferase
I6G90_16805	COG0204	Acyl-transferase
I6G90_16810	COG0606	chelatase, subunit chli
I6G90_16820	COG3978	acetolactate synthase activity
I6G90_16830	COG0129	dihydroxy-acid dehydratase activity
I6G90_16845	COG3385	transposase activity
I6G90_16850	COG2391	methyltransferase activity
I6G90_16855	COG0840	transmembrane signaling receptor activity
I6G90_16860	COG2962	Rard protein
I6G90_16870	COG1012	belongs to the aldehyde dehydrogenase family
I6G90_16875	COG1396	sequence-specific DNA binding
I6G90_16880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G90_16890	COG0519	Catalyzes the synthesis of GMP from XMP
I6G90_16890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G90_16895	COG0583	DNA-binding transcription factor activity
I6G90_16900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_16920	COG1322	Protein conserved in bacteria
I6G90_16925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G90_16930	COG2204	response regulator
I6G90_16945	COG0174	glutamine synthetase
I6G90_16950	COG1217	gtp-binding protein TYPA
I6G90_16955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G90_16960	COG0569	domain protein
I6G90_16965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G90_16965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G90_16970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G90_16975	COG0242	peptide deformylase activity
I6G90_16980	COG1652	LysM domain
I6G90_16985	COG0758	DNA mediated transformation
I6G90_16990	COG2922	Belongs to the Smg family
I6G90_16995	COG0551	DNA topoisomerase type I activity
I6G90_17005	COG0009	L-threonylcarbamoyladenylate synthase
I6G90_17010	COG0408	coproporphyrinogen oxidase activity
I6G90_17015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G90_17025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G90_17035	COG3078	GTPase activator activity
I6G90_17045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G90_17075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G90_17080	COG1288	antiporter activity
I6G90_17085	COG1438	arginine binding
I6G90_17090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6G90_17095	COG0540	Belongs to the ATCase OTCase family
I6G90_17125	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6G90_17140	COG3040	lipid binding
I6G90_17145	COG2207	Transcriptional regulator
I6G90_17150	COG1979	alcohol dehydrogenase
I6G90_17155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G90_17160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G90_17165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_17170	COG2964	Protein conserved in bacteria
I6G90_17175	COG3681	Belongs to the UPF0597 family
I6G90_17185	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G90_17190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G90_17195	COG0564	pseudouridine synthase activity
I6G90_17205	COG0542	response to heat
I6G90_17210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G90_17215	COG2502	aspartate--ammonia ligase
I6G90_17220	COG1522	sequence-specific DNA binding
I6G90_17230	COG5413	integral membrane protein
I6G90_17235	COG0517	IMP dehydrogenase activity
I6G90_17235	COG0516	GMP reductase activity
I6G90_17255	COG2205	protein histidine kinase activity
I6G90_17265	COG2204	response regulator
I6G90_17310	COG0243	molybdopterin cofactor binding
I6G90_17315	COG3005	denitrification pathway
I6G90_17320	COG4191	Histidine kinase
I6G90_17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_17335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G90_17340	COG0569	domain protein
I6G90_17345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G90_17370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G90_17385	COG0250	Participates in transcription elongation, termination and antitermination
I6G90_17390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G90_17395	COG0081	regulation of translation
I6G90_17400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G90_17405	COG0222	ribosome binding
I6G90_17410	COG0085	RNA polymerase activity
I6G90_17415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G90_17420	COG2964	Protein conserved in bacteria
I6G90_17430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G90_17435	COG2923	Belongs to the DsrF TusC family
I6G90_17440	COG2168	tRNA wobble position uridine thiolation
I6G90_17445	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G90_17450	COG0049	tRNA binding
I6G90_17455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G90_17460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G90_17465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G90_17515	COG3714	YhhN family
I6G90_17540	COG1301	dicarboxylic acid transport
I6G90_17550	COG2095	MarC family integral membrane protein
I6G90_17560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G90_17570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G90_17580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G90_17595	COG1770	oligopeptidase
I6G90_17610	COG4221	oxidoreductase activity
I6G90_17615	COG0583	DNA-binding transcription factor activity
I6G90_17620	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G90_17645	COG0742	ribosomal rna small subunit methyltransferase
I6G90_17650	COG0552	protein localization to endoplasmic reticulum
I6G90_17655	COG2884	Cell division ATP-binding protein ftsE
I6G90_17660	COG2177	Part of the ABC transporter FtsEX involved in
I6G90_17670	COG3385	transposase activity
I6G90_17675	COG0288	reversible hydration of carbon dioxide
I6G90_17680	COG2188	Transcriptional regulator
I6G90_17685	COG1228	amidohydrolase
I6G90_17690	COG0010	Belongs to the arginase family
I6G90_17695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G90_17700	COG2986	histidine ammonia-lyase
I6G90_17705	COG0387	Pfam Sodium calcium exchanger
I6G90_17715	COG2199	diguanylate cyclase activity
I6G90_17715	COG2200	EAL domain
I6G90_17760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G90_17765	COG1459	type II secretion system
I6G90_17775	COG2165	general secretion pathway protein
I6G90_17780	COG2165	general secretion pathway protein
I6G90_17785	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6G90_17810	COG1077	Cell shape determining protein MreB Mrl
I6G90_17815	COG1792	Involved in formation and maintenance of cell shape
I6G90_17820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G90_17825	COG0424	maF-like protein
I6G90_17830	COG1530	ribonuclease E activity
I6G90_17835	COG3164	Protein of unknown function
I6G90_17845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G90_17850	COG0312	modulator of DNA gyrase
I6G90_17870	COG0477	Major facilitator Superfamily
I6G90_17915	COG0189	ligase activity
I6G90_17920	COG0642	Histidine kinase
I6G90_17925	COG0745	RESPONSE REGULATOR receiver
I6G90_17940	COG0789	Transcriptional regulator
I6G90_17945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G90_17950	COG0352	thiamine-phosphate diphosphorylase activity
I6G90_17955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G90_17965	COG2022	thiamine diphosphate biosynthetic process
I6G90_17970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G90_17975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G90_17990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G90_18010	COG0583	DNA-binding transcription factor activity
I6G90_18015	COG1380	Effector of murein hydrolase LrgA
I6G90_18020	COG1346	cytolysis
I6G90_18035	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G90_18040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G90_18045	COG1546	Belongs to the CinA family
I6G90_18050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G90_18060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G90_18070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G90_18105	COG1686	Belongs to the peptidase S11 family
I6G90_18110	COG0586	Pfam SNARE associated Golgi protein
I6G90_18115	COG1253	flavin adenine dinucleotide binding
I6G90_18120	COG0252	asparaginase activity
I6G90_18140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_18140	COG1263	PTS System
I6G90_18145	COG0366	Alpha amylase catalytic
I6G90_18150	COG0110	maltose O-acetyltransferase activity
I6G90_18160	COG0564	pseudouridine synthase activity
I6G90_18165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G90_18200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G90_18200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G90_18215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G90_18220	COG0038	chloride channel
I6G90_18230	COG0316	Belongs to the HesB IscA family
I6G90_18235	COG1757	Na H antiporter
I6G90_18275	COG0297	glycogen (starch) synthase activity
I6G90_18280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G90_18285	COG2813	Specifically methylates the guanine in position
I6G90_18290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G90_18300	COG1392	Phosphate transport regulator
I6G90_18305	COG0306	phosphate transporter
I6G90_18310	COG0460	homoserine dehydrogenase
I6G90_18310	COG0527	aspartate kinase activity
I6G90_18315	COG0626	cystathionine gamma-synthase activity
I6G90_18325	COG0814	amino acid
I6G90_18330	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G90_18335	COG0494	nUDIX hydrolase
I6G90_18340	COG1011	Hydrolase
I6G90_18355	COG0110	maltose O-acetyltransferase activity
I6G90_18360	COG3174	membrane
I6G90_18365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G90_18375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G90_18380	COG4208	sulfate ABC transporter
I6G90_18385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G90_18390	COG0583	DNA-binding transcription factor activity
I6G90_18395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G90_18400	COG0765	amino acid transport
I6G90_18410	COG1126	abc transporter atp-binding protein
I6G90_18415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_18420	COG3397	chitin binding
I6G90_18425	COG0840	transmembrane signaling receptor activity
I6G90_18440	COG0726	polysaccharide deacetylase
I6G90_18440	COG1649	PFAM Uncharacterised BCR, COG1649
I6G90_18445	COG1215	transferase activity, transferring glycosyl groups
I6G90_18475	COG1328	CTP reductase activity
I6G90_18480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G90_18495	COG1448	Aminotransferase
I6G90_18500	COG2194	sulfuric ester hydrolase activity
I6G90_18515	COG1215	transferase activity, transferring glycosyl groups
I6G90_18520	COG1215	transferase activity, transferring glycosyl groups
I6G90_18530	COG0457	Tetratricopeptide repeat
I6G90_18530	COG3118	belongs to the thioredoxin family
I6G90_18565	COG0513	Belongs to the DEAD box helicase family
I6G90_18590	COG3112	Uncharacterised protein family (UPF0231)
I6G90_18600	COG3835	regulator
I6G90_18605	COG2610	gluconate transmembrane transporter activity
I6G90_18610	COG1929	Belongs to the glycerate kinase type-1 family
I6G90_18630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G90_18640	COG1872	DUF167
I6G90_18645	COG0762	integral membrane protein
I6G90_18650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G90_18655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G90_18670	COG3022	response to hydroperoxide
I6G90_18690	COG0347	Belongs to the P(II) protein family
I6G90_18695	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G90_18705	COG3842	ATPase activity
I6G90_18710	COG2837	iron assimilation
I6G90_18715	COG1438	arginine binding
I6G90_18720	COG1126	abc transporter atp-binding protein
I6G90_18725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G90_18730	COG4215	(ABC) transporter
I6G90_18735	COG4160	amino acid transport
I6G90_18740	COG0039	L-malate dehydrogenase activity
I6G90_18745	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6G90_18750	COG1017	nitric oxide dioxygenase activity
I6G90_18750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G90_18760	COG4536	flavin adenine dinucleotide binding
I6G90_18765	COG4137	Cytochrome C assembly protein
I6G90_18770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G90_18775	COG0228	four-way junction DNA binding
I6G90_18780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G90_18785	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G90_18790	COG0335	large ribosomal subunit rRNA binding
I6G90_18800	COG3066	DNA modification
I6G90_18805	COG1051	belongs to the nudix hydrolase family
I6G90_18815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G90_18820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G90_18825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G90_18835	COG0583	DNA-binding transcription factor activity
I6G90_18840	COG0640	Transcriptional regulator
I6G90_18845	COG0268	Binds directly to 16S ribosomal RNA
I6G90_18850	COG0728	peptidoglycan biosynthetic process
I6G90_18855	COG0196	riboflavin kinase activity
I6G90_18860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G90_18865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G90_18870	COG1047	Peptidyl-prolyl cis-trans
I6G90_18875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G90_18920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G90_18920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G90_18935	COG1854	S-ribosylhomocysteine lyase activity
I6G90_18940	COG2165	general secretion pathway protein
I6G90_18945	COG0084	hydrolase, TatD family'
I6G90_18950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G90_18960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G90_18965	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G90_18970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G90_18980	COG3447	MASE1 domain protein
I6G90_18980	COG5001	Diguanylate cyclase
I6G90_18980	COG5002	protein histidine kinase activity
I6G90_18990	COG0560	Phosphoserine phosphatase
I6G90_19005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G90_19020	COG0776	regulation of translation
I6G90_19030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G90_19035	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G90_19040	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G90_19045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G90_19050	COG0359	binds to the 23S rRNA
I6G90_19055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G90_19075	COG1064	alcohol dehydrogenase
I6G90_19080	COG1238	metal cluster binding
I6G90_19085	COG0612	Peptidase, M16
I6G90_19090	COG2918	glutathione biosynthetic process
I6G90_19100	COG1022	Amp-dependent synthetase and ligase
I6G90_19110	COG0456	acetyltransferase
I6G90_19135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G90_19155	COG0477	Major facilitator Superfamily
I6G90_19160	COG0583	DNA-binding transcription factor activity
I6G90_19170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G90_19175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G90_19185	COG0673	inositol 2-dehydrogenase activity
I6G90_19195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G90_19200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G90_19205	COG3036	rescue of stalled ribosome
I6G90_19215	COG0138	bifunctional purine biosynthesis protein purh
I6G90_19220	COG0151	Belongs to the GarS family
I6G90_19240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G90_19245	COG0358	DNA primase activity
I6G90_19250	COG1610	YqeY-like protein
I6G90_19255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G90_19260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G90_19265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G90_19270	COG1027	Aspartate ammonia-lyase
I6G90_19275	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G90_19280	COG0534	Mate efflux family protein
I6G90_19285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G90_19290	COG0459	protein refolding
I6G90_19340	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G90_19345	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G90_19350	COG1178	ABC-type Fe3 transport system permease component
I6G90_19355	COG4143	(ABC) transporter
I6G90_19370	COG0066	3-isopropylmalate dehydratase activity
I6G90_19375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G90_19380	COG0473	3-isopropylmalate dehydrogenase activity
I6G90_19385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G90_19410	COG0028	Belongs to the TPP enzyme family
I6G90_19415	COG0440	acetolactate synthase activity
I6G90_19455	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G90_19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G90_19500	COG0745	RESPONSE REGULATOR receiver
I6G90_19505	COG3104	oligopeptide transport
I6G90_19510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G90_19515	COG1555	photosystem II stabilization
I6G90_19520	COG0280	phosphate acetyltransferase
I6G90_19520	COG0857	belongs to the CobB CobQ family
I6G90_19525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G90_19535	COG3013	Belongs to the UPF0304 family
I6G90_19540	COG3385	transposase activity
I6G90_19545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G90_19550	COG2716	regulation of RNA biosynthetic process
I6G90_19555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G90_19560	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G90_19565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G90_19600	COG0784	Response regulator, receiver
I6G90_19600	COG2198	Histidine kinase
I6G90_19600	COG5002	protein histidine kinase activity
I6G90_19615	COG0784	Response regulator, receiver
I6G90_19615	COG2205	protein histidine kinase activity
I6G90_19615	COG5002	protein histidine kinase activity
I6G90_19635	COG1464	Belongs to the NlpA lipoprotein family
I6G90_19640	COG2011	ABC-type metal ion transport system permease component
I6G90_19645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G90_19665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G90_19665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G90_19670	COG0802	atpase or kinase
I6G90_19680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G90_19685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G90_19690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G90_19695	COG1923	regulation of RNA biosynthetic process
I6G90_19700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G90_19705	COG0330	HflC and HflK could
I6G90_19710	COG0330	HflC and HflK could
I6G90_19715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G90_19720	COG0142	geranyltranstransferase activity
I6G90_19725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G90_19730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G90_19735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G90_19740	COG3314	Sporulation integral membrane protein YlbJ
I6G90_19745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G90_19755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G90_19760	COG2967	ApaG domain
I6G90_19765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G90_19770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G90_19775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G90_19780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G90_19785	COG3178	'Phosphotransferase
I6G90_19790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G90_19795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G90_19800	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G90_19805	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G90_19810	COG1073	alpha beta
I6G90_19825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G90_19840	COG4628	conserved protein (DUF2132)
I6G90_19845	COG0688	phosphatidylethanolamine metabolic process
I6G90_19855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G90_19895	COG1278	Cold shock
I6G90_19905	COG0840	transmembrane signaling receptor activity
I6G90_19910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G90_19915	COG2252	PERMEase
I6G90_19925	COG0488	(ABC) transporter
I6G90_19940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G90_19945	COG0741	lytic transglycosylase activity
I6G90_19970	COG4608	Belongs to the ABC transporter superfamily
I6G90_19975	COG0444	Belongs to the ABC transporter superfamily
I6G90_19985	COG4239	(ABC) transporter, permease
I6G90_19990	COG4174	ABC transporter (Permease)
I6G90_20000	COG0616	signal peptide processing
I6G90_20005	COG1902	pentaerythritol trinitrate reductase activity
I6G90_20005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G90_20010	COG0778	Nitroreductase
I6G90_20015	COG0110	maltose O-acetyltransferase activity
I6G90_20020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G90_20025	COG2264	protein methyltransferase activity
I6G90_20030	COG0604	alcohol dehydrogenase
I6G90_20035	COG0583	DNA-binding transcription factor activity
I6G90_20040	COG1263	PTS System
I6G90_20040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G90_20040	COG2190	(PTS) system
I6G90_20045	COG4145	pantothenate transmembrane transporter activity
I6G90_20055	COG0439	Biotin carboxylase
I6G90_20060	COG0511	ligase activity, forming carbon-carbon bonds
I6G90_20065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G90_20070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G90_20100	COG3381	protein complex oligomerization
I6G90_20110	COG3005	denitrification pathway
I6G90_20115	COG0745	RESPONSE REGULATOR receiver
I6G90_20125	COG1879	ABC-type sugar transport system periplasmic component
I6G90_20130	COG2198	Histidine kinase
I6G90_20130	COG0784	Response regulator, receiver
I6G90_20130	COG2205	protein histidine kinase activity
I6G90_20145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G90_20150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G90_20155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G90_20155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G90_20170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G90_20175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G90_20180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G90_20185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G90_20200	COG0601	transmembrane transport
I6G90_20210	COG2900	Belongs to the SlyX family
I6G90_20220	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G90_20225	COG2204	response regulator
I6G90_20250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G90_20255	COG4991	sh3 domain protein
I6G90_20265	COG2816	NAD+ diphosphatase activity
I6G90_20270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G90_20275	COG1940	carbohydrate kinase activity
I6G90_20280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G90_20285	COG0126	phosphoglycerate kinase activity
I6G90_20290	COG0191	fructose-bisphosphate aldolase activity
I6G90_20295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G90_20335	COG0354	folic acid binding
I6G90_20340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G90_20350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G90_20355	COG1595	DNA-templated transcription, initiation
I6G90_20360	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6G90_20365	COG3026	antisigma factor binding
I6G90_20375	COG0481	GTPase activity
I6G90_20380	COG0681	Belongs to the peptidase S26 family
I6G90_20385	COG0571	ribonuclease III activity
I6G90_20395	COG1381	Involved in DNA repair and RecF pathway recombination
I6G90_20400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G90_20410	COG2350	Protein conserved in bacteria
I6G90_20415	COG2917	probably involved in intracellular septation
I6G90_20420	COG0076	glutamate decarboxylase activity
I6G90_20425	COG1272	protein, Hemolysin III
I6G90_20430	COG2985	domain, Protein
I6G90_20430	COG0569	domain protein
I6G90_20450	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6G90_20475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G90_20480	COG1028	Short-chain dehydrogenase reductase Sdr
I6G90_20485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G90_20490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G90_20525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G90_20530	COG0318	PFAM AMP-dependent synthetase and ligase
I6G90_20540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G90_20575	COG2313	pseudouridylate synthase activity
I6G90_20580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G90_20620	COG1765	OsmC-like protein
I6G90_20635	COG3954	Phosphoribulokinase
I6G90_20640	COG3089	Belongs to the UPF0270 family
I6G90_20645	COG3706	GGDEF domain
I6G90_20665	COG0784	Response regulator, receiver
I6G90_20665	COG0835	chemotaxis
I6G90_20675	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G90_20680	COG1047	Peptidyl-prolyl cis-trans
I6G90_20690	COG0305	Participates in initiation and elongation during chromosome replication
I6G90_20695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G90_20705	COG3340	Belongs to the peptidase S51 family
I6G90_20710	COG1966	Carbon starvation protein
I6G90_20715	COG3279	Response regulator of the LytR AlgR family
I6G90_20720	COG3275	phosphorelay sensor kinase activity
I6G90_20735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G90_20745	COG3721	Heme iron utilization protein
I6G90_20750	COG0748	coenzyme F420 binding
I6G90_20775	COG2814	Major facilitator Superfamily
I6G90_20785	COG3655	Transcriptional regulator
I6G90_20795	COG2205	protein histidine kinase activity
I6G90_20795	COG2202	Pas domain
I6G90_20800	COG3706	GGDEF domain
I6G90_20810	COG3397	chitin binding
I6G90_20845	COG0835	chemotaxis
I6G90_20845	COG0784	Response regulator, receiver
I6G90_20850	COG2755	lipolytic protein G-D-S-L family
I6G90_20855	COG4181	ATPase activity
I6G90_20860	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G90_20865	COG1090	epimerase
I6G90_20870	COG2200	EAL domain
I6G90_20875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G90_20880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G90_20885	COG3171	Protein conserved in bacteria
I6G90_20890	COG2066	Belongs to the glutaminase family
I6G90_20895	COG2897	thiosulfate sulfurtransferase activity
I6G90_20910	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G90_20920	COG2966	Psort location CytoplasmicMembrane, score
I6G90_20935	COG4175	Glycine betaine
I6G90_20940	COG4176	ABC-type proline glycine betaine transport system permease component
I6G90_20945	COG2113	Glycine betaine
I6G90_20960	COG3385	transposase activity
I6G90_20965	COG2171	N-acyltransferase activity
I6G90_20975	COG0024	Methionine aminopeptidase
I6G90_20980	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G90_20985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G90_20990	COG0528	UMP kinase activity
I6G90_20995	COG0233	cytoplasmic translational termination
I6G90_21000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G90_21005	COG0575	Belongs to the CDS family
I6G90_21010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G90_21015	COG0750	zinc metalloprotease
I6G90_21020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G90_21030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G90_21035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G90_21040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G90_21045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G90_21050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G90_21060	COG0825	malonyl-CoA metabolic process
I6G90_21070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G90_21075	COG1115	amino acid carrier protein
I6G90_21090	COG0714	Associated with various cellular activities
I6G90_21110	COG5433	transposase activity
I6G90_21130	COG3104	oligopeptide transport
I6G90_21135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G90_21140	COG1678	Uncharacterized ACR, COG1678
I6G90_21150	COG0189	ligase activity
I6G90_21155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G90_21165	COG3091	SprT-like family
I6G90_21175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G90_21185	COG0251	oxidation-reduction process
I6G90_21190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G90_21195	COG0739	heme binding
I6G90_21200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)