locus-tag	class	description
GWG05_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWG05_00010	COG0592	DNA-directed DNA polymerase activity
GWG05_00020	COG0187	DNA topoisomerase II activity
GWG05_00025	COG2207	Transcriptional regulator
GWG05_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWG05_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG05_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG05_00045	COG3977	Valine--pyruvate aminotransferase
GWG05_00065	COG0745	RESPONSE REGULATOR receiver
GWG05_00070	COG2205	protein histidine kinase activity
GWG05_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG05_00100	COG4191	Histidine kinase
GWG05_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_00115	COG1309	transcriptional regulator
GWG05_00145	COG0561	phosphatase activity
GWG05_00150	COG2267	carboxylic ester hydrolase activity
GWG05_00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG05_00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG05_00165	COG1758	RNA polymerase activity
GWG05_00175	COG0859	PFAM glycosyl transferase family 9
GWG05_00180	COG3642	lipopolysaccharide core region biosynthetic process
GWG05_00220	COG0589	response to stress
GWG05_00225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG05_00230	COG3706	GGDEF domain
GWG05_00235	COG1528	Iron-storage protein
GWG05_00240	COG2081	HI0933 family
GWG05_00245	COG2223	nitrite transmembrane transporter activity
GWG05_00265	COG3188	usher protein
GWG05_00290	COG5433	transposase activity
GWG05_00305	COG3275	phosphorelay sensor kinase activity
GWG05_00310	COG3279	Response regulator of the LytR AlgR family
GWG05_00315	COG2223	nitrite transmembrane transporter activity
GWG05_00320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWG05_00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWG05_00375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWG05_00380	COG2166	iron-sulfur cluster assembly
GWG05_00385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWG05_00405	COG1063	alcohol dehydrogenase
GWG05_00420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG05_00465	COG1609	Transcriptional regulator
GWG05_00485	COG1580	Controls the rotational direction of flagella during chemotaxis
GWG05_00490	COG3161	chorismate lyase activity
GWG05_00495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWG05_00500	COG2937	Belongs to the GPAT DAPAT family
GWG05_00505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWG05_00525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWG05_00530	COG2205	protein histidine kinase activity
GWG05_00535	COG0745	RESPONSE REGULATOR receiver
GWG05_00545	COG1045	serine acetyltransferase
GWG05_00555	COG3074	FtsZ-dependent cytokinesis
GWG05_00560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWG05_00565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_00565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_00570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWG05_00605	COG1609	Transcriptional regulator
GWG05_00610	COG3250	beta-galactosidase activity
GWG05_00615	COG2731	YhcH YjgK YiaL family protein
GWG05_00620	COG0531	amino acid
GWG05_00625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_00630	COG0531	amino acid
GWG05_00635	COG0385	Bile acid
GWG05_00640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWG05_00665	COG0583	DNA-binding transcription factor activity
GWG05_00700	COG0210	DNA helicase
GWG05_00715	COG1943	Transposase
GWG05_00720	COG0583	DNA-binding transcription factor activity
GWG05_00760	COG1280	lysine exporter protein (LysE YggA)
GWG05_00770	COG2962	Rard protein
GWG05_00775	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_00780	COG1396	sequence-specific DNA binding
GWG05_00795	COG0519	Catalyzes the synthesis of GMP from XMP
GWG05_00795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG05_00805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_00825	COG1322	Protein conserved in bacteria
GWG05_00830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_00835	COG0569	domain protein
GWG05_00840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_00840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_00845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWG05_00850	COG0242	peptide deformylase activity
GWG05_00860	COG0758	DNA mediated transformation
GWG05_00865	COG2922	Belongs to the Smg family
GWG05_00870	COG0551	DNA topoisomerase type I activity
GWG05_00875	COG0009	L-threonylcarbamoyladenylate synthase
GWG05_00880	COG0408	coproporphyrinogen oxidase activity
GWG05_00885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWG05_00890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWG05_00900	COG3078	GTPase activator activity
GWG05_00915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG05_00925	COG3852	Histidine kinase
GWG05_00935	COG0174	glutamine synthetase
GWG05_00945	COG1295	ribonuclease BN
GWG05_00950	COG1490	D-aminoacyl-tRNA deacylase activity
GWG05_00960	COG0456	acetyltransferase
GWG05_00970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWG05_00975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG05_00980	COG2610	gluconate transmembrane transporter activity
GWG05_00985	COG3265	gluconokinase activity
GWG05_00990	COG0129	dihydroxy-acid dehydratase activity
GWG05_00995	COG0800	Aldolase
GWG05_01010	COG1609	Transcriptional regulator
GWG05_01020	COG4942	peptidase
GWG05_01025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWG05_01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_01035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWG05_01040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWG05_01045	COG0316	Belongs to the HesB IscA family
GWG05_01045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWG05_01050	COG1040	competence protein
GWG05_01055	COG0596	Alpha beta hydrolase
GWG05_01070	COG2183	response to ionizing radiation
GWG05_01075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG05_01080	COG0745	RESPONSE REGULATOR receiver
GWG05_01085	COG2205	protein histidine kinase activity
GWG05_01095	COG0051	transcription antitermination factor activity, RNA binding
GWG05_01100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWG05_01105	COG0088	Forms part of the polypeptide exit tunnel
GWG05_01110	COG0089	rRNA binding
GWG05_01115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWG05_01120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWG05_01125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWG05_01130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWG05_01135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWG05_01140	COG0255	Belongs to the universal ribosomal protein uL29 family
GWG05_01145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWG05_01150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWG05_01155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWG05_01160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWG05_01165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWG05_01170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWG05_01175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWG05_01180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWG05_01185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWG05_01190	COG1841	ribosomal large subunit assembly
GWG05_01195	COG0200	Binds to the 23S rRNA
GWG05_01200	COG0201	protein transport
GWG05_01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG05_01210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWG05_01215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWG05_01220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWG05_01225	COG0202	RNA polymerase activity
GWG05_01230	COG0203	ribosomal protein L17
GWG05_01285	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWG05_01290	COG0583	DNA-binding transcription factor activity
GWG05_01295	COG4221	oxidoreductase activity
GWG05_01310	COG1770	oligopeptidase
GWG05_01315	COG2358	TRAP transporter, solute receptor (TAXI family
GWG05_01330	COG3714	YhhN family
GWG05_01345	COG0583	DNA-binding transcription factor activity
GWG05_01355	COG1301	dicarboxylic acid transport
GWG05_01365	COG2095	MarC family integral membrane protein
GWG05_01375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_01385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG05_01395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG05_01420	COG0742	ribosomal rna small subunit methyltransferase
GWG05_01425	COG0552	protein localization to endoplasmic reticulum
GWG05_01430	COG2884	Cell division ATP-binding protein ftsE
GWG05_01435	COG2177	Part of the ABC transporter FtsEX involved in
GWG05_01445	COG0288	reversible hydration of carbon dioxide
GWG05_01450	COG2188	Transcriptional regulator
GWG05_01455	COG1228	amidohydrolase
GWG05_01460	COG0010	Belongs to the arginase family
GWG05_01465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWG05_01470	COG2986	histidine ammonia-lyase
GWG05_01475	COG0387	Pfam Sodium calcium exchanger
GWG05_01480	COG2200	EAL domain
GWG05_01535	COG1459	type II secretion system
GWG05_01550	COG4969	Belongs to the N-Me-Phe pilin family
GWG05_01555	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG05_01580	COG1077	Cell shape determining protein MreB Mrl
GWG05_01585	COG1792	Involved in formation and maintenance of cell shape
GWG05_01590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWG05_01595	COG0424	maF-like protein
GWG05_01600	COG1530	ribonuclease E activity
GWG05_01605	COG3164	Protein of unknown function
GWG05_01610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_01615	COG0312	modulator of DNA gyrase
GWG05_01635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_01635	COG1263	PTS System
GWG05_01640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWG05_01655	COG0477	Major facilitator Superfamily
GWG05_01665	COG2321	neutral zinc metallopeptidase
GWG05_01700	COG0189	ligase activity
GWG05_01705	COG0642	Histidine kinase
GWG05_01710	COG0745	RESPONSE REGULATOR receiver
GWG05_01725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWG05_01730	COG0352	thiamine-phosphate diphosphorylase activity
GWG05_01735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG05_01745	COG2022	thiamine diphosphate biosynthetic process
GWG05_01750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG05_01765	COG0110	maltose O-acetyltransferase activity
GWG05_01775	COG2199	diguanylate cyclase activity
GWG05_01775	COG2203	Gaf domain
GWG05_01780	COG3932	Exopolysaccharide synthesis, ExoD
GWG05_01800	COG1733	regulation of RNA biosynthetic process
GWG05_01830	COG1494	fructose-1,6-bisphosphatase
GWG05_01840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWG05_01845	COG5007	Belongs to the BolA IbaG family
GWG05_01855	COG2854	intermembrane phospholipid transfer
GWG05_01860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG05_01865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWG05_01870	COG1127	ABC transporter
GWG05_01875	COG0517	IMP dehydrogenase activity
GWG05_01875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWG05_01880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWG05_01890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWG05_01895	COG1137	ATPase activity
GWG05_01900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWG05_01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_01915	COG1660	Displays ATPase and GTPase activities
GWG05_01920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_01940	COG3964	amidohydrolase
GWG05_01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG05_01975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG05_01985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWG05_01990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWG05_01995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWG05_02000	COG0723	plastoquinol--plastocyanin reductase activity
GWG05_02005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWG05_02010	COG2857	Cytochrome c1
GWG05_02015	COG0625	glutathione transferase activity
GWG05_02020	COG2969	positive regulation of protein catabolic process
GWG05_02025	COG2823	Periplasmic or secreted lipoprotein
GWG05_02030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG05_02035	COG0792	nuclease activity
GWG05_02040	COG3107	peptidoglycan biosynthetic process
GWG05_02045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWG05_02055	COG2001	Belongs to the MraZ family
GWG05_02060	COG0275	rRNA processing
GWG05_02065	COG3116	cell division
GWG05_02070	COG0768	penicillin binding
GWG05_02075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWG05_02080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWG05_02085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG05_02090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWG05_02095	COG0772	Belongs to the SEDS family
GWG05_02100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWG05_02105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG05_02110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWG05_02115	COG0849	cell division
GWG05_02120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWG05_02125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWG05_02135	COG0653	protein targeting
GWG05_02145	COG0494	nUDIX hydrolase
GWG05_02150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWG05_02155	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWG05_02165	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWG05_02170	COG1459	type II secretion system
GWG05_02175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG05_02200	COG2186	Transcriptional regulator
GWG05_02205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWG05_02210	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG05_02215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG05_02225	COG0840	transmembrane signaling receptor activity
GWG05_02230	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG05_02235	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWG05_02250	COG1280	lysine exporter protein (LysE YggA)
GWG05_02260	COG0523	cobalamin synthesis protein
GWG05_02265	COG0477	Major facilitator Superfamily
GWG05_02280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWG05_02285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWG05_02330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWG05_02340	COG1546	Belongs to the CinA family
GWG05_02345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWG05_02350	COG2137	regulation of response to DNA damage stimulus
GWG05_02355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWG05_02360	COG0527	aspartate kinase activity
GWG05_02365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWG05_02400	COG1686	Belongs to the peptidase S11 family
GWG05_02405	COG0586	Pfam SNARE associated Golgi protein
GWG05_02410	COG1253	flavin adenine dinucleotide binding
GWG05_02415	COG0525	valine-tRNA ligase activity
GWG05_02425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG05_02430	COG0795	lipopolysaccharide-transporting ATPase activity
GWG05_02435	COG0795	lipopolysaccharide-transporting ATPase activity
GWG05_02455	COG0004	ammonium transporteR
GWG05_02460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_02470	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG05_02475	COG0084	hydrolase, TatD family'
GWG05_02480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG05_02490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWG05_02495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWG05_02500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWG05_02505	COG0813	purine-nucleoside phosphorylase activity
GWG05_02510	COG5001	Diguanylate cyclase
GWG05_02510	COG5002	protein histidine kinase activity
GWG05_02510	COG3447	MASE1 domain protein
GWG05_02520	COG0560	Phosphoserine phosphatase
GWG05_02535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWG05_02545	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWG05_02550	COG0776	regulation of translation
GWG05_02565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG05_02570	COG0735	belongs to the Fur family
GWG05_02590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWG05_02595	COG0513	Belongs to the DEAD box helicase family
GWG05_02600	COG3022	response to hydroperoxide
GWG05_02605	COG2805	Type II/IV secretion system protein
GWG05_02615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWG05_02620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWG05_02625	COG0762	integral membrane protein
GWG05_02630	COG1872	DUF167
GWG05_02650	COG3112	Uncharacterised protein family (UPF0231)
GWG05_02655	COG3835	regulator
GWG05_02660	COG2610	gluconate transmembrane transporter activity
GWG05_02665	COG1929	Belongs to the glycerate kinase type-1 family
GWG05_02680	COG0583	DNA-binding transcription factor activity
GWG05_02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG05_02700	COG0347	Belongs to the P(II) protein family
GWG05_02715	COG3842	ATPase activity
GWG05_02720	COG2837	iron assimilation
GWG05_02725	COG1438	arginine binding
GWG05_02730	COG1126	abc transporter atp-binding protein
GWG05_02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_02740	COG4215	(ABC) transporter
GWG05_02745	COG4160	amino acid transport
GWG05_02750	COG0039	L-malate dehydrogenase activity
GWG05_02755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWG05_02760	COG1017	nitric oxide dioxygenase activity
GWG05_02760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG05_02770	COG4536	flavin adenine dinucleotide binding
GWG05_02775	COG4137	Cytochrome C assembly protein
GWG05_02780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWG05_02785	COG0228	four-way junction DNA binding
GWG05_02790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWG05_02795	COG0336	Belongs to the RNA methyltransferase TrmD family
GWG05_02800	COG0335	large ribosomal subunit rRNA binding
GWG05_02815	COG1051	belongs to the nudix hydrolase family
GWG05_02825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWG05_02830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWG05_02835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG05_02845	COG0583	DNA-binding transcription factor activity
GWG05_02850	COG0640	Transcriptional regulator
GWG05_02855	COG0268	Binds directly to 16S ribosomal RNA
GWG05_02860	COG0728	peptidoglycan biosynthetic process
GWG05_02865	COG0196	riboflavin kinase activity
GWG05_02870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWG05_02875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWG05_02880	COG1047	Peptidyl-prolyl cis-trans
GWG05_02885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWG05_02925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWG05_02925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_02940	COG1854	S-ribosylhomocysteine lyase activity
GWG05_02945	COG3706	GGDEF domain
GWG05_02950	COG0557	exoribonuclease II activity
GWG05_02955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG05_02965	COG2153	protein acetylation
GWG05_02975	COG1914	H( )-stimulated, divalent metal cation uptake system
GWG05_02980	COG0360	Binds together with S18 to 16S ribosomal RNA
GWG05_02985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWG05_02990	COG0359	binds to the 23S rRNA
GWG05_03025	COG1238	metal cluster binding
GWG05_03030	COG0612	Peptidase, M16
GWG05_03035	COG2918	glutathione biosynthetic process
GWG05_03040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG05_03045	COG1027	Aspartate ammonia-lyase
GWG05_03050	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWG05_03055	COG0534	Mate efflux family protein
GWG05_03060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWG05_03065	COG0459	protein refolding
GWG05_03085	COG0564	pseudouridine synthase activity
GWG05_03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG05_03120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWG05_03130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWG05_03135	COG4208	sulfate ABC transporter
GWG05_03140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWG05_03145	COG0583	DNA-binding transcription factor activity
GWG05_03150	COG3397	chitin binding
GWG05_03180	COG1328	CTP reductase activity
GWG05_03185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG05_03200	COG1448	Aminotransferase
GWG05_03225	COG1215	transferase activity, transferring glycosyl groups
GWG05_03230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GWG05_03235	COG0457	Tetratricopeptide repeat
GWG05_03235	COG3118	belongs to the thioredoxin family
GWG05_03270	COG0513	Belongs to the DEAD box helicase family
GWG05_03275	COG0840	transmembrane signaling receptor activity
GWG05_03285	COG4166	transmembrane transport
GWG05_03300	COG1024	Enoyl-CoA hydratase
GWG05_03315	COG4221	oxidoreductase activity
GWG05_03320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_03325	COG0442	prolyl-tRNA aminoacylation
GWG05_03330	COG0840	transmembrane signaling receptor activity
GWG05_03335	COG0632	four-way junction helicase activity
GWG05_03340	COG2255	four-way junction helicase activity
GWG05_03350	COG1271	oxidase subunit
GWG05_03355	COG1294	oxidase, subunit
GWG05_03360	COG4890	Cyd operon protein YbgT
GWG05_03365	COG3790	cyd operon protein YbgE
GWG05_03370	COG0824	Thioesterase
GWG05_03375	COG0811	peptide transport
GWG05_03390	COG0823	Involved in the tonB-independent uptake of proteins
GWG05_03395	COG2885	chlorophyll binding
GWG05_03400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWG05_03475	COG0840	transmembrane signaling receptor activity
GWG05_03480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWG05_03490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG05_03495	COG1640	4-alpha-glucanotransferase
GWG05_03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWG05_03525	COG1051	belongs to the nudix hydrolase family
GWG05_03530	COG2130	NADP-dependent
GWG05_03535	COG1846	Transcriptional regulator
GWG05_03565	COG0561	phosphatase activity
GWG05_03580	COG0733	neurotransmitter:sodium symporter activity
GWG05_03585	COG0733	neurotransmitter:sodium symporter activity
GWG05_03600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_03615	COG1794	racemase activity, acting on amino acids and derivatives
GWG05_03625	COG1022	Amp-dependent synthetase and ligase
GWG05_03635	COG0456	acetyltransferase
GWG05_03650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWG05_03655	COG5002	protein histidine kinase activity
GWG05_03655	COG5001	Diguanylate cyclase
GWG05_03675	COG0456	acetyltransferase
GWG05_03685	COG0456	acetyltransferase
GWG05_03690	COG1902	pentaerythritol trinitrate reductase activity
GWG05_03700	COG2852	Protein conserved in bacteria
GWG05_03710	COG2957	Belongs to the agmatine deiminase family
GWG05_03715	COG0154	amidase activity
GWG05_03750	COG1917	Cupin 2, conserved barrel domain protein
GWG05_03750	COG2207	Transcriptional regulator
GWG05_03760	COG0513	Belongs to the DEAD box helicase family
GWG05_03765	COG2203	Gaf domain
GWG05_03765	COG2199	diguanylate cyclase activity
GWG05_03800	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWG05_03810	COG1136	(ABC) transporter
GWG05_03810	COG0577	efflux transmembrane transporter activity
GWG05_03815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_03820	COG0745	RESPONSE REGULATOR receiver
GWG05_03825	COG2205	protein histidine kinase activity
GWG05_03875	COG1280	lysine exporter protein (LysE YggA)
GWG05_03880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWG05_03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_03925	COG0745	RESPONSE REGULATOR receiver
GWG05_03930	COG3104	oligopeptide transport
GWG05_03935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWG05_03940	COG1555	photosystem II stabilization
GWG05_03950	COG2350	Protein conserved in bacteria
GWG05_03955	COG2917	probably involved in intracellular septation
GWG05_03960	COG0076	glutamate decarboxylase activity
GWG05_03965	COG1272	protein, Hemolysin III
GWG05_03970	COG0569	domain protein
GWG05_03970	COG2985	domain, Protein
GWG05_03980	COG0477	Major facilitator Superfamily
GWG05_03985	COG0583	DNA-binding transcription factor activity
GWG05_03990	COG3227	Zinc metalloprotease (Elastase)
GWG05_03995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_04000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_04010	COG2731	YhcH YjgK YiaL family protein
GWG05_04020	COG0668	transmembrane transport
GWG05_04030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG05_04040	COG0789	Transcriptional regulator
GWG05_04055	COG3039	Transposase
GWG05_04065	COG3039	Transposase
GWG05_04105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWG05_04115	COG0488	(ABC) transporter
GWG05_04120	COG0516	GMP reductase activity
GWG05_04120	COG0517	IMP dehydrogenase activity
GWG05_04130	COG0835	chemotaxis
GWG05_04130	COG0784	Response regulator, receiver
GWG05_04135	COG2755	lipolytic protein G-D-S-L family
GWG05_04140	COG4181	ATPase activity
GWG05_04145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWG05_04150	COG1090	epimerase
GWG05_04155	COG2200	EAL domain
GWG05_04160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_04165	COG2234	aminopeptidase activity
GWG05_04165	COG4935	Belongs to the peptidase S8 family
GWG05_04170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWG05_04175	COG3171	Protein conserved in bacteria
GWG05_04180	COG2066	Belongs to the glutaminase family
GWG05_04185	COG2897	thiosulfate sulfurtransferase activity
GWG05_04195	COG1132	(ABC) transporter
GWG05_04220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWG05_04225	COG5001	Diguanylate cyclase
GWG05_04225	COG3300	MHYT domain
GWG05_04245	COG4628	conserved protein (DUF2132)
GWG05_04250	COG0688	phosphatidylethanolamine metabolic process
GWG05_04255	COG1162	GTPase activity
GWG05_04260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWG05_04300	COG1278	Cold shock
GWG05_04310	COG0840	transmembrane signaling receptor activity
GWG05_04315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_04365	COG0848	biopolymer transport protein
GWG05_04370	COG0811	peptide transport
GWG05_04375	COG0811	peptide transport
GWG05_04390	COG4174	ABC transporter (Permease)
GWG05_04395	COG4239	(ABC) transporter, permease
GWG05_04405	COG0444	Belongs to the ABC transporter superfamily
GWG05_04410	COG4608	Belongs to the ABC transporter superfamily
GWG05_04420	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG05_04430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWG05_04450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWG05_04475	COG0243	molybdopterin cofactor binding
GWG05_04480	COG1648	precorrin-2 dehydrogenase activity
GWG05_04480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_04490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWG05_04490	COG1116	anion transmembrane transporter activity
GWG05_04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWG05_04500	COG1116	anion transmembrane transporter activity
GWG05_04505	COG2146	nitrite reductase [NAD(P)H] activity
GWG05_04505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_04510	COG2146	nitrite reductase [NAD(P)H] activity
GWG05_04510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_04515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_04520	COG2313	pseudouridylate synthase activity
GWG05_04525	COG2313	pseudouridylate synthase activity
GWG05_04550	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG05_04560	COG2966	Psort location CytoplasmicMembrane, score
GWG05_04575	COG4175	Glycine betaine
GWG05_04580	COG4176	ABC-type proline glycine betaine transport system permease component
GWG05_04585	COG2113	Glycine betaine
GWG05_04590	COG0175	sulfate reduction
GWG05_04595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_04600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWG05_04610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWG05_04625	COG0786	glutamate:sodium symporter activity
GWG05_04630	COG0252	asparaginase activity
GWG05_04635	COG3139	Protein of unknown function (DUF1315)
GWG05_04655	COG0616	signal peptide processing
GWG05_04660	COG1902	pentaerythritol trinitrate reductase activity
GWG05_04660	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_04665	COG0778	Nitroreductase
GWG05_04675	COG0110	maltose O-acetyltransferase activity
GWG05_04680	COG2264	protein methyltransferase activity
GWG05_04685	COG0604	alcohol dehydrogenase
GWG05_04690	COG0583	DNA-binding transcription factor activity
GWG05_04695	COG2190	(PTS) system
GWG05_04695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_04695	COG1263	PTS System
GWG05_04700	COG4145	pantothenate transmembrane transporter activity
GWG05_04705	COG3924	membrane
GWG05_04710	COG0439	Biotin carboxylase
GWG05_04715	COG0511	ligase activity, forming carbon-carbon bonds
GWG05_04720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWG05_04725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG05_04740	COG3381	protein complex oligomerization
GWG05_04750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWG05_04760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWG05_04765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG05_04765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG05_04780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWG05_04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_04790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWG05_04795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWG05_04800	COG4172	Belongs to the ABC transporter superfamily
GWG05_04820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWG05_04825	COG0142	geranyltranstransferase activity
GWG05_04830	COG1722	exodeoxyribonuclease VII activity
GWG05_04835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_04840	COG1360	Flagellar Motor Protein
GWG05_04855	COG1534	Rna-binding protein
GWG05_04860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWG05_04870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWG05_04875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWG05_04880	COG0149	triose-phosphate isomerase activity
GWG05_04885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWG05_04900	COG0779	Required for maturation of 30S ribosomal subunits
GWG05_04905	COG0195	Participates in both transcription termination and antitermination
GWG05_04910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWG05_04915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWG05_04920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWG05_04925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWG05_04930	COG1185	polyribonucleotide nucleotidyltransferase activity
GWG05_04935	COG2211	Major facilitator Superfamily
GWG05_04940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG05_04945	COG1422	Protein of unknown function (DUF1090)
GWG05_04950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_04975	COG0312	modulator of DNA gyrase
GWG05_04985	COG0312	modulator of DNA gyrase
GWG05_04995	COG4974	Belongs to the 'phage' integrase family
GWG05_05000	COG1970	mechanosensitive ion channel activity
GWG05_05015	COG0789	Transcriptional regulator
GWG05_05030	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_05040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWG05_05045	COG0321	lipoyl(octanoyl) transferase activity
GWG05_05050	COG2921	Belongs to the UPF0250 family
GWG05_05055	COG1686	Belongs to the peptidase S11 family
GWG05_05060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWG05_05065	COG2951	lytic endotransglycosylase activity
GWG05_05070	COG0772	Belongs to the SEDS family
GWG05_05075	COG0768	penicillin binding
GWG05_05080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWG05_05085	COG0799	negative regulation of ribosome biogenesis
GWG05_05090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWG05_05110	COG0495	leucyl-tRNA aminoacylation
GWG05_05115	COG2888	peptidyl-tyrosine sulfation
GWG05_05120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWG05_05125	COG4535	Mg2 and Co2 transporter CorC
GWG05_05130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWG05_05135	COG1702	phosphate starvation-inducible protein PhoH
GWG05_05140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG05_05145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_05150	COG1335	isochorismatase
GWG05_05155	COG1278	Cold shock
GWG05_05170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_05175	COG2199	diguanylate cyclase activity
GWG05_05185	COG2199	diguanylate cyclase activity
GWG05_05195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG05_05210	COG1464	Belongs to the NlpA lipoprotein family
GWG05_05215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG05_05220	COG2011	ABC-type metal ion transport system permease component
GWG05_05225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWG05_05235	COG0516	GMP reductase activity
GWG05_05240	COG4067	protein conserved in archaea
GWG05_05240	COG0189	ligase activity
GWG05_05260	COG0300	oxidoreductase activity
GWG05_05280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_05285	COG3214	Protein conserved in bacteria
GWG05_05300	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG05_05305	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG05_05310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWG05_05315	COG1053	succinate dehydrogenase
GWG05_05325	COG0584	glycerophosphoryl diester phosphodiesterase
GWG05_05330	COG3264	Mechanosensitive ion channel
GWG05_05330	COG1511	domain protein
GWG05_05340	COG0739	heme binding
GWG05_05355	COG0583	DNA-binding transcription factor activity
GWG05_05370	COG0583	DNA-binding transcription factor activity
GWG05_05375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWG05_05405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWG05_05410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWG05_05420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWG05_05425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWG05_05430	COG0546	phosphoglycolate phosphatase activity
GWG05_05435	COG0180	Tryptophanyl-tRNA synthetase
GWG05_05450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWG05_05460	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_05490	COG2801	Transposase and inactivated derivatives
GWG05_05495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_05520	COG0490	domain, Protein
GWG05_05520	COG0471	metal ion transport
GWG05_05565	COG0012	GTP binding
GWG05_05570	COG0193	aminoacyl-tRNA hydrolase activity
GWG05_05575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWG05_05585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWG05_05590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWG05_05595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWG05_05600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWG05_05605	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG05_05615	COG2912	Transglutaminase-like superfamily
GWG05_05620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWG05_05625	COG1301	dicarboxylic acid transport
GWG05_05635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWG05_05650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWG05_05655	COG1115	amino acid carrier protein
GWG05_05675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWG05_05685	COG0189	ligase activity
GWG05_05690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWG05_05700	COG3091	SprT-like family
GWG05_05710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWG05_05720	COG2801	Transposase and inactivated derivatives
GWG05_05740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWG05_05745	COG0739	heme binding
GWG05_05750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG05_05755	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GWG05_05755	COG3408	Glycogen debranching enzyme
GWG05_05765	COG1881	PFAM PEBP family protein
GWG05_05775	COG0583	DNA-binding transcription factor activity
GWG05_05785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWG05_05795	COG0583	DNA-binding transcription factor activity
GWG05_05800	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_05805	COG0616	signal peptide processing
GWG05_05810	COG3724	N-succinylarginine dihydrolase activity
GWG05_05825	COG0840	transmembrane signaling receptor activity
GWG05_05835	COG2971	BadF BadG BcrA BcrD
GWG05_05845	COG4608	Belongs to the ABC transporter superfamily
GWG05_05850	COG0444	Belongs to the ABC transporter superfamily
GWG05_05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_05870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG05_05880	COG0640	Transcriptional regulator
GWG05_05885	COG0798	PFAM Bile acid sodium symporter
GWG05_05890	COG1393	Belongs to the ArsC family
GWG05_05905	COG1677	Flagellar hook-basal body complex protein FliE
GWG05_05915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWG05_05970	COG1684	flagellar biosynthetic protein fliR
GWG05_05980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWG05_06005	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWG05_06010	COG0643	Histidine kinase
GWG05_06010	COG0784	Response regulator, receiver
GWG05_06010	COG2198	Histidine kinase
GWG05_06020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_06025	COG1360	Flagellar Motor Protein
GWG05_06030	COG1192	Involved in chromosome partitioning
GWG05_06040	COG0835	chemotaxis
GWG05_06055	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_06060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_06065	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_06070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWG05_06075	COG1138	Cytochrome C-type biogenesis protein
GWG05_06080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_06090	COG0457	Tetratricopeptide repeat
GWG05_06105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWG05_06110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_06110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_06125	COG0259	pyridoxamine-phosphate oxidase activity
GWG05_06155	COG3153	acetyltransferase
GWG05_06170	COG0800	Aldolase
GWG05_06175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_06185	COG2721	sulfolactate sulfo-lyase activity
GWG05_06190	COG0246	Mannitol dehydrogenase
GWG05_06225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWG05_06230	COG2867	negative regulation of translational initiation
GWG05_06240	COG0702	epimerase
GWG05_06245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_06255	COG2932	Transcriptional regulator
GWG05_06355	COG0640	Transcriptional regulator
GWG05_06365	COG4373	Mu-like prophage FluMu protein gp28
GWG05_06370	COG4383	Mu-like prophage protein gp29
GWG05_06395	COG4388	Caudovirus prohead serine protease
GWG05_06400	COG4397	Mu-like prophage major head subunit gpT
GWG05_06495	COG1957	nucleoside hydrolase
GWG05_06520	COG1280	lysine exporter protein (LysE YggA)
GWG05_06530	COG3263	regulation of cellular component size
GWG05_06540	COG1876	peptidase activity
GWG05_06545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWG05_06550	COG1393	Belongs to the ArsC family
GWG05_06560	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG05_06575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG05_06580	COG0017	Asparaginyl-tRNA synthetase
GWG05_06600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG05_06605	COG0156	8-amino-7-oxononanoate synthase activity
GWG05_06610	COG2226	methyltransferase
GWG05_06610	COG1073	alpha beta
GWG05_06615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWG05_06620	COG0501	Belongs to the peptidase M48B family
GWG05_06625	COG3217	Mosc domain protein beta barrel domain protein
GWG05_06625	COG0633	Ferredoxin
GWG05_06625	COG3217	Mosc domain protein beta barrel domain protein
GWG05_06625	COG0633	Ferredoxin
GWG05_06635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWG05_06635	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWG05_06635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWG05_06635	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWG05_06640	COG2841	Protein conserved in bacteria
GWG05_06650	COG0534	Mate efflux family protein
GWG05_06675	COG1454	alcohol dehydrogenase
GWG05_06685	COG1309	transcriptional regulator
GWG05_06700	COG0791	NLP P60 protein
GWG05_06705	COG0583	DNA-binding transcription factor activity
GWG05_06725	COG0500	methyltransferase
GWG05_06730	COG4106	trans-aconitate 2-methyltransferase activity
GWG05_06735	COG1801	Protein of unknown function DUF72
GWG05_06745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWG05_06750	COG0217	transcriptional regulatory protein
GWG05_06755	COG2194	sulfuric ester hydrolase activity
GWG05_06760	COG1940	carbohydrate kinase activity
GWG05_06760	COG1846	Transcriptional regulator
GWG05_06765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG05_06770	COG0363	glucosamine-6-phosphate deaminase activity
GWG05_06775	COG2190	(PTS) system
GWG05_06775	COG1263	PTS System
GWG05_06775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_06785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_06790	COG0735	belongs to the Fur family
GWG05_06800	COG0716	FMN binding
GWG05_06815	COG0596	Alpha beta hydrolase
GWG05_06820	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWG05_06825	COG0033	Phosphoglucomutase
GWG05_06835	COG1846	Transcriptional regulator
GWG05_06840	COG2951	lytic endotransglycosylase activity
GWG05_06845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWG05_06850	COG4136	ATPase activity
GWG05_06860	COG4134	Bacterial extracellular solute-binding protein
GWG05_06870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG05_06880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG05_06890	COG0729	surface antigen
GWG05_06895	COG2911	Protein conserved in bacteria
GWG05_06910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWG05_06920	COG0741	lytic transglycosylase activity
GWG05_06935	COG1607	acyl-coa hydrolase
GWG05_06950	COG0741	lytic transglycosylase activity
GWG05_06950	COG1388	LysM domain
GWG05_06955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG05_06960	COG2226	methyltransferase
GWG05_06965	COG0328	RNA-DNA hybrid ribonuclease activity
GWG05_06975	COG3039	Transposase
GWG05_07005	COG1484	DNA-dependent DNA replication
GWG05_07010	COG4584	PFAM Integrase catalytic
GWG05_07050	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_07065	COG3039	Transposase
GWG05_07070	COG2850	peptidyl-arginine hydroxylation
GWG05_07095	COG1484	DNA-dependent DNA replication
GWG05_07180	COG4974	Belongs to the 'phage' integrase family
GWG05_07185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_07200	COG1960	acyl-CoA dehydrogenase activity
GWG05_07205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG05_07210	COG0121	glutamine amidotransferase
GWG05_07220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWG05_07245	COG2197	response regulator
GWG05_07250	COG3850	Histidine kinase
GWG05_07255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWG05_07260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_07260	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_07270	COG0243	molybdopterin cofactor binding
GWG05_07275	COG0437	4 iron, 4 sulfur cluster binding
GWG05_07280	COG0348	domain, Protein
GWG05_07290	COG3005	denitrification pathway
GWG05_07295	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG05_07300	COG0315	cyclic pyranopterin monophosphate synthase activity
GWG05_07305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWG05_07310	COG0314	molybdopterin synthase activity
GWG05_07325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWG05_07330	COG2267	carboxylic ester hydrolase activity
GWG05_07335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG05_07345	COG0302	gtp cyclohydrolase
GWG05_07350	COG0840	transmembrane signaling receptor activity
GWG05_07365	COG0583	DNA-binding transcription factor activity
GWG05_07380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWG05_07395	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG05_07400	COG1166	arginine decarboxylase activity
GWG05_07460	COG2801	Transposase and inactivated derivatives
GWG05_07470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWG05_07475	COG1187	pseudouridine synthase activity
GWG05_07480	COG2807	transmembrane transport
GWG05_07490	COG0583	DNA-binding transcription factor activity
GWG05_07510	COG2979	Protein of unknown function (DUF533)
GWG05_07520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_07525	COG1271	oxidase subunit
GWG05_07530	COG1294	oxidase, subunit
GWG05_07540	COG2814	Major facilitator Superfamily
GWG05_07545	COG0656	L-ascorbic acid biosynthetic process
GWG05_07565	COG0583	DNA-binding transcription factor activity
GWG05_07570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWG05_07575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG05_07580	COG2271	Major facilitator Superfamily
GWG05_07585	COG1349	DNA-binding transcription factor activity
GWG05_07595	COG0584	glycerophosphoryl diester phosphodiesterase
GWG05_07600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_07605	COG0287	Prephenate dehydrogenase
GWG05_07605	COG1605	Chorismate mutase
GWG05_07615	COG3085	chromosome segregation
GWG05_07620	COG4574	serine-type endopeptidase inhibitor activity
GWG05_07640	COG1770	oligopeptidase
GWG05_07645	COG4771	TonB-dependent receptor
GWG05_07650	COG3083	sulfuric ester hydrolase activity
GWG05_07655	COG3082	Protein of unknown function (DUF1414)
GWG05_07660	COG3081	Nucleoid-associated protein
GWG05_07670	COG1175	transmembrane transport
GWG05_07675	COG3833	ABC-type maltose transport systems, permease component
GWG05_07680	COG3842	ATPase activity
GWG05_07690	COG0596	Alpha beta hydrolase
GWG05_07705	COG0425	Belongs to the sulfur carrier protein TusA family
GWG05_07710	COG4783	chaperone-mediated protein folding
GWG05_07720	COG1393	Belongs to the ArsC family
GWG05_07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_07750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG05_07755	COG2431	L-lysine efflux transmembrane transporter activity
GWG05_07765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_07775	COG4160	amino acid transport
GWG05_07785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG05_07795	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_07800	COG0628	permease
GWG05_07805	COG2373	Large extracellular alpha-helical protein
GWG05_07810	COG4953	penicillin-binding protein 1C
GWG05_07820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_07820	COG0301	tRNA thio-modification
GWG05_07835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWG05_07845	COG1334	flagellar protein FlaG
GWG05_07880	COG2089	acid synthase
GWG05_07890	COG1083	cytidylyl-transferase
GWG05_07905	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_07910	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_07925	COG1216	Glycosyl transferase, family 2
GWG05_07990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWG05_07995	COG1086	Polysaccharide biosynthesis protein
GWG05_08000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG05_08010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWG05_08025	COG0346	lactoylglutathione lyase activity
GWG05_08030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWG05_08035	COG4660	Part of a membrane complex involved in electron transport
GWG05_08040	COG4659	FMN binding
GWG05_08045	COG4658	electron transport chain
GWG05_08055	COG2878	Part of a membrane complex involved in electron transport
GWG05_08060	COG4657	Part of a membrane complex involved in electron transport
GWG05_08065	COG0675	Transposase, IS605 OrfB family
GWG05_08075	COG0697	spore germination
GWG05_08095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG05_08100	COG1288	antiporter activity
GWG05_08105	COG0436	Aminotransferase
GWG05_08115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWG05_08120	COG2027	D-alanyl-D-alanine carboxypeptidase
GWG05_08125	COG1061	Type III restriction enzyme res subunit
GWG05_08130	COG1566	PFAM secretion protein HlyD family protein
GWG05_08140	COG1966	Carbon starvation protein
GWG05_08145	COG3279	Response regulator of the LytR AlgR family
GWG05_08150	COG3275	phosphorelay sensor kinase activity
GWG05_08160	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_08160	COG1454	alcohol dehydrogenase
GWG05_08165	COG2095	MarC family integral membrane protein
GWG05_08175	COG0601	transmembrane transport
GWG05_08180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_08185	COG0444	Belongs to the ABC transporter superfamily
GWG05_08195	COG0861	Integral membrane protein TerC family
GWG05_08200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG05_08210	COG1301	dicarboxylic acid transport
GWG05_08230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWG05_08245	COG0537	adenosine 5'-monophosphoramidase activity
GWG05_08280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_08285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_08300	COG2354	Protein conserved in bacteria
GWG05_08305	COG1164	Oligoendopeptidase f
GWG05_08310	COG1164	Oligoendopeptidase f
GWG05_08315	COG3150	esterase
GWG05_08320	COG1252	NADH dehydrogenase
GWG05_08325	COG0393	Putative heavy-metal-binding
GWG05_08330	COG1368	sulfuric ester hydrolase activity
GWG05_08340	COG0527	aspartate kinase activity
GWG05_08345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG05_08345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWG05_08350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWG05_08375	COG0583	DNA-binding transcription factor activity
GWG05_08380	COG1620	l-lactate permease
GWG05_08385	COG0247	lactate metabolic process
GWG05_08390	COG1139	Iron-sulfur cluster binding protein
GWG05_08415	COG1136	(ABC) transporter
GWG05_08435	COG2814	Major facilitator Superfamily
GWG05_08460	COG0672	)-iron permease
GWG05_08495	COG2308	Evidence 4 Homologs of previously reported genes of
GWG05_08510	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_08530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWG05_08535	COG0326	Molecular chaperone. Has ATPase activity
GWG05_08540	COG0563	adenylate kinase activity
GWG05_08545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWG05_08550	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWG05_08555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_08560	COG0840	transmembrane signaling receptor activity
GWG05_08575	COG3300	MHYT domain
GWG05_08575	COG5001	Diguanylate cyclase
GWG05_08600	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWG05_08605	COG3433	isochorismatase activity
GWG05_08605	COG1535	isochorismatase
GWG05_08610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG05_08615	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_08625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG05_08640	COG1120	ATPase activity
GWG05_08645	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_08650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_08655	COG4771	TonB-dependent receptor
GWG05_08695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWG05_08700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWG05_08705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_08710	COG0861	Integral membrane protein TerC family
GWG05_08725	COG1022	Amp-dependent synthetase and ligase
GWG05_08730	COG0295	cytidine deaminase activity
GWG05_08735	COG1346	cytolysis
GWG05_08740	COG1380	Effector of murein hydrolase LrgA
GWG05_08745	COG3345	alpha-galactosidase
GWG05_08755	COG2925	Exonuclease
GWG05_08760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG05_08765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWG05_08765	COG0392	lysyltransferase activity
GWG05_08780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_08785	COG0436	Aminotransferase
GWG05_08790	COG0583	DNA-binding transcription factor activity
GWG05_08795	COG2160	L-arabinose isomerase activity
GWG05_08805	COG1069	ribulokinase activity
GWG05_08810	COG1879	ABC-type sugar transport system periplasmic component
GWG05_08815	COG1129	ABC transporter
GWG05_08820	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_08830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG05_08835	COG0254	rRNA binding
GWG05_08850	COG1451	nucleotide metabolic process
GWG05_08865	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG05_08875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWG05_08875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_08880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG05_08900	COG2009	succinate dehydrogenase
GWG05_08905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWG05_08920	COG0567	Dehydrogenase, E1 component
GWG05_08925	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG05_08930	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG05_08935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWG05_08940	COG2801	Transposase and inactivated derivatives
GWG05_08955	COG2983	Belongs to the UPF0260 family
GWG05_08960	COG1882	Formate acetyltransferase
GWG05_08965	COG2116	formate transmembrane transporter activity
GWG05_08970	COG1944	ATP diphosphatase activity
GWG05_08980	COG2076	Multidrug Resistance protein
GWG05_08985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG05_08990	COG1278	Cold shock
GWG05_08995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWG05_09000	COG0542	response to heat
GWG05_09005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWG05_09010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWG05_09015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWG05_09020	COG3134	Outer membrane lipoprotein
GWG05_09025	COG3706	GGDEF domain
GWG05_09030	COG0492	ferredoxin-NADP+ reductase activity
GWG05_09035	COG0686	Belongs to the AlaDH PNT family
GWG05_09045	COG1674	ftsk spoiiie
GWG05_09045	COG0531	amino acid
GWG05_09050	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWG05_09055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWG05_09060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWG05_09065	COG1286	toxin biosynthetic process
GWG05_09070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWG05_09075	COG2723	6-phospho-beta-galactosidase activity
GWG05_09080	COG1263	PTS System
GWG05_09080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_09085	COG1609	Transcriptional regulator
GWG05_09095	COG4172	Belongs to the ABC transporter superfamily
GWG05_09105	COG4171	peptide transport system, permease
GWG05_09120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWG05_09125	COG1842	Phage shock protein A
GWG05_09140	COG3106	COG3106 Predicted ATPase
GWG05_09145	COG3768	UPF0283 membrane protein
GWG05_09155	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWG05_09175	COG2885	chlorophyll binding
GWG05_09185	COG1570	exodeoxyribonuclease VII activity
GWG05_09195	COG0366	Alpha amylase catalytic
GWG05_09195	COG1874	Beta-galactosidase
GWG05_09205	COG0517	IMP dehydrogenase activity
GWG05_09205	COG0516	GMP reductase activity
GWG05_09210	COG0519	Catalyzes the synthesis of GMP from XMP
GWG05_09210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG05_09220	COG3039	Transposase
GWG05_09245	COG1846	Transcriptional regulator
GWG05_09255	COG0500	methyltransferase
GWG05_09265	COG2062	phosphohistidine phosphatase, SixA
GWG05_09275	COG0697	spore germination
GWG05_09290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWG05_09295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWG05_09305	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG05_09310	COG1136	(ABC) transporter
GWG05_09315	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG05_09320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GWG05_09330	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWG05_09335	COG0740	serine-type endopeptidase activity
GWG05_09340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWG05_09345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWG05_09350	COG0776	regulation of translation
GWG05_09355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG05_09360	COG0488	(ABC) transporter
GWG05_09365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG05_09370	COG3162	membrane
GWG05_09385	COG1024	Enoyl-CoA hydratase
GWG05_09390	COG1115	amino acid carrier protein
GWG05_09400	COG3228	Belongs to the MtfA family
GWG05_09405	COG1584	GPR1 FUN34 yaaH family protein
GWG05_09430	COG1024	Enoyl-CoA hydratase
GWG05_09435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWG05_09440	COG1960	acyl-CoA dehydrogenase activity
GWG05_09450	COG1960	acyl-CoA dehydrogenase activity
GWG05_09455	COG1024	Enoyl-CoA hydratase
GWG05_09460	COG1024	Enoyl-CoA hydratase
GWG05_09470	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_09480	COG0730	response to heat
GWG05_09510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG05_09560	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_09565	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_09570	COG1129	ABC transporter
GWG05_09575	COG1879	ABC-type sugar transport system periplasmic component
GWG05_09580	COG0583	DNA-binding transcription factor activity
GWG05_09595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWG05_09600	COG0243	molybdopterin cofactor binding
GWG05_09610	COG0583	DNA-binding transcription factor activity
GWG05_09615	COG2723	6-phospho-beta-galactosidase activity
GWG05_09625	COG0583	DNA-binding transcription factor activity
GWG05_09640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWG05_09645	COG0673	inositol 2-dehydrogenase activity
GWG05_09650	COG0583	DNA-binding transcription factor activity
GWG05_09660	COG1560	Kdo2-lipid A biosynthetic process
GWG05_09665	COG1560	Kdo2-lipid A biosynthetic process
GWG05_09680	COG0417	DNA replication proofreading
GWG05_09710	COG0534	Mate efflux family protein
GWG05_09720	COG0307	riboflavin synthase, alpha
GWG05_09735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_09740	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWG05_09775	COG0675	Transposase, IS605 OrfB family
GWG05_09780	COG2996	Protein conserved in bacteria
GWG05_09795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG05_09800	COG3099	Belongs to the UPF0263 family
GWG05_09805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWG05_09810	COG2894	cell division
GWG05_09815	COG0850	regulation of cytokinetic process
GWG05_09820	COG3100	YcgL domain-containing protein
GWG05_09825	COG2951	lytic endotransglycosylase activity
GWG05_09830	COG1760	l-serine dehydratase
GWG05_09835	COG1760	l-serine dehydratase
GWG05_09840	COG3123	guanosine phosphorylase activity
GWG05_09845	COG1301	dicarboxylic acid transport
GWG05_09860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWG05_09865	COG2067	long-chain fatty acid transport protein
GWG05_09870	COG2067	long-chain fatty acid transport protein
GWG05_09880	COG1595	DNA-templated transcription, initiation
GWG05_09910	COG0714	Associated with various cellular activities
GWG05_09915	COG0183	Belongs to the thiolase family
GWG05_09920	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG05_09920	COG1024	Enoyl-CoA hydratase
GWG05_09930	COG4681	YaeQ
GWG05_09950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_09965	COG3134	Outer membrane lipoprotein
GWG05_09970	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_09990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWG05_09990	COG0140	phosphoribosyl-ATP diphosphatase activity
GWG05_09995	COG0107	imidazoleglycerol-phosphate synthase activity
GWG05_10000	COG2198	Histidine kinase
GWG05_10000	COG0784	Response regulator, receiver
GWG05_10000	COG2205	protein histidine kinase activity
GWG05_10010	COG3437	response regulator, receiver
GWG05_10015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWG05_10020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWG05_10025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG05_10025	COG0131	Imidazoleglycerol-phosphate dehydratase
GWG05_10030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWG05_10035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWG05_10040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWG05_10050	COG1199	ATP-dependent helicase activity
GWG05_10055	COG1214	PFAM Peptidase M22, glycoprotease
GWG05_10065	COG0596	Alpha beta hydrolase
GWG05_10070	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_10085	COG0697	spore germination
GWG05_10095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG05_10100	COG2832	Protein of unknown function (DUF454)
GWG05_10105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWG05_10115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWG05_10120	COG0583	DNA-binding transcription factor activity
GWG05_10185	COG2197	response regulator
GWG05_10190	COG0617	tRNA 3'-terminal CCA addition
GWG05_10190	COG0517	IMP dehydrogenase activity
GWG05_10190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG05_10195	COG1643	Atp-dependent helicase
GWG05_10205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWG05_10220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG05_10225	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWG05_10230	COG0709	Synthesizes selenophosphate from selenide and ATP
GWG05_10245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG05_10250	COG0840	transmembrane signaling receptor activity
GWG05_10255	COG1254	Belongs to the acylphosphatase family
GWG05_10265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_10265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_10270	COG0489	protein tyrosine kinase activity
GWG05_10275	COG0572	uridine kinase
GWG05_10280	COG0717	Belongs to the dCTP deaminase family
GWG05_10285	COG0306	phosphate transporter
GWG05_10290	COG1530	ribonuclease E activity
GWG05_10295	COG0564	pseudouridine synthase activity
GWG05_10310	COG1399	metal-binding, possibly nucleic acid-binding protein
GWG05_10315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWG05_10320	COG0416	fatty acid biosynthetic process
GWG05_10325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWG05_10335	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_10340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWG05_10345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG05_10350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWG05_10355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWG05_10360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWG05_10365	COG0470	DNA polymerase III
GWG05_10370	COG0084	hydrolase, TatD family'
GWG05_10435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWG05_10435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_10440	COG3008	intermembrane lipid transfer
GWG05_10445	COG2995	paraquat-inducible protein a
GWG05_10455	COG3141	response to X-ray
GWG05_10480	COG1074	ATP-dependent DNA helicase activity
GWG05_10500	COG0583	DNA-binding transcription factor activity
GWG05_10525	COG0633	Ferredoxin
GWG05_10530	COG0789	Transcriptional regulator
GWG05_10540	COG0640	Transcriptional regulator
GWG05_10545	COG2814	Major facilitator Superfamily
GWG05_10550	COG1937	Protein conserved in bacteria
GWG05_10555	COG1230	cation diffusion facilitator family transporter
GWG05_10560	COG0640	Transcriptional regulator
GWG05_10570	COG1484	DNA-dependent DNA replication
GWG05_10575	COG4584	PFAM Integrase catalytic
GWG05_10630	COG5499	transcription regulator containing HTH domain
GWG05_10645	COG0789	Transcriptional regulator
GWG05_10670	COG1067	ATP-dependent peptidase activity
GWG05_10675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG05_10700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG05_10700	COG0116	Belongs to the methyltransferase superfamily
GWG05_10710	COG0167	dihydroorotate dehydrogenase activity
GWG05_10715	COG2902	Dehydrogenase
GWG05_10725	COG0308	aminopeptidase N
GWG05_10735	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWG05_10740	COG1956	GAF domain-containing protein
GWG05_10755	COG3278	Belongs to the heme-copper respiratory oxidase family
GWG05_10770	COG2010	Cytochrome c
GWG05_10780	COG2217	Heavy metal translocating P-type atpase
GWG05_10795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG05_10800	COG0589	response to stress
GWG05_10805	COG0037	tRNA processing
GWG05_10820	COG0625	glutathione transferase activity
GWG05_10825	COG1869	D-ribose catabolic process
GWG05_10830	COG1129	ABC transporter
GWG05_10835	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_10840	COG1879	ABC-type sugar transport system periplasmic component
GWG05_10845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_10850	COG1609	Transcriptional regulator
GWG05_10885	COG0776	regulation of translation
GWG05_10890	COG0072	phenylalanine-tRNA ligase activity
GWG05_10890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_10895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWG05_10900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWG05_10905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWG05_10910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWG05_10915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWG05_10945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_10955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_10960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_10965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG05_10970	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWG05_10975	COG3313	Fe-S protein
GWG05_10980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG05_10980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG05_10980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWG05_10985	COG1105	Belongs to the carbohydrate kinase PfkB family
GWG05_10990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_10990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_10995	COG1609	Transcriptional regulator
GWG05_11000	COG0814	amino acid
GWG05_11010	COG5654	RES domain protein
GWG05_11015	COG0513	Belongs to the DEAD box helicase family
GWG05_11025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWG05_11030	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG05_11035	COG2840	Smr protein MutS2
GWG05_11070	COG2824	Alkylphosphonate utilization operon protein PhnA
GWG05_11135	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWG05_11140	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWG05_11150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_11155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWG05_11165	COG0205	6-phosphofructokinase activity
GWG05_11170	COG1473	amidohydrolase
GWG05_11175	COG1011	Hydrolase
GWG05_11180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG05_11225	COG3593	DNA synthesis involved in DNA repair
GWG05_11240	COG0583	DNA-binding transcription factor activity
GWG05_11245	COG0730	response to heat
GWG05_11260	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWG05_11270	COG0386	Belongs to the glutathione peroxidase family
GWG05_11275	COG0513	Belongs to the DEAD box helicase family
GWG05_11310	COG2329	Antibiotic biosynthesis monooxygenase
GWG05_11315	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWG05_11345	COG2501	S4 domain
GWG05_11365	COG1132	(ABC) transporter
GWG05_11370	COG1132	(ABC) transporter
GWG05_11380	COG3118	belongs to the thioredoxin family
GWG05_11385	COG0471	metal ion transport
GWG05_11395	COG0058	SHG alpha-glucan phosphorylase activity
GWG05_11425	COG0814	amino acid
GWG05_11430	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWG05_11435	COG0514	ATP-dependent DNA helicase (RecQ)
GWG05_11440	COG2766	serine protein kinase
GWG05_11445	COG2718	Belongs to the UPF0229 family
GWG05_11450	COG2719	SpoVR family
GWG05_11455	COG2186	Transcriptional regulator
GWG05_11460	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG05_11465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWG05_11470	COG0586	Pfam SNARE associated Golgi protein
GWG05_11480	COG0556	nucleotide-excision repair
GWG05_11490	COG0569	domain protein
GWG05_11490	COG2985	domain, Protein
GWG05_11495	COG0739	heme binding
GWG05_11495	COG0741	lytic transglycosylase activity
GWG05_11495	COG1196	nuclear chromosome segregation
GWG05_11500	COG3181	Tripartite tricarboxylate transporter family receptor
GWG05_11515	COG4565	transcriptional regulatory protein
GWG05_11520	COG3290	protein histidine kinase activity
GWG05_11525	COG1846	Transcriptional regulator
GWG05_11525	COG1940	carbohydrate kinase activity
GWG05_11530	COG0840	transmembrane signaling receptor activity
GWG05_11535	COG3012	SEC-C Motif Domain Protein
GWG05_11540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWG05_11545	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWG05_11550	COG0247	lactate metabolic process
GWG05_11570	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWG05_11575	COG0437	4 iron, 4 sulfur cluster binding
GWG05_11580	COG3301	Polysulphide reductase, NrfD
GWG05_11590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_11595	COG4235	cytochrome complex assembly
GWG05_11595	COG3088	subunit of a heme lyase
GWG05_11610	COG3046	protein related to deoxyribodipyrimidine photolyase
GWG05_11615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_11630	COG0617	tRNA 3'-terminal CCA addition
GWG05_11630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG05_11630	COG0517	IMP dehydrogenase activity
GWG05_11640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWG05_11645	COG0583	DNA-binding transcription factor activity
GWG05_11655	COG4774	siderophore transport
GWG05_11660	COG2199	diguanylate cyclase activity
GWG05_11660	COG2203	Gaf domain
GWG05_11665	COG2200	EAL domain
GWG05_11670	COG4977	sequence-specific DNA binding
GWG05_11670	COG1917	Cupin 2, conserved barrel domain protein
GWG05_11675	COG0583	DNA-binding transcription factor activity
GWG05_11680	COG2910	NAD(P)H-binding
GWG05_11690	COG0626	cystathionine gamma-synthase activity
GWG05_11695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWG05_11730	COG0745	RESPONSE REGULATOR receiver
GWG05_11740	COG3039	Transposase
GWG05_11750	COG3250	beta-galactosidase activity
GWG05_11755	COG2223	nitrite transmembrane transporter activity
GWG05_11775	COG1609	Transcriptional regulator
GWG05_11780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_11785	COG1085	galactose-1-phosphate uridylyltransferase
GWG05_11790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG05_11795	COG0469	pyruvate kinase activity
GWG05_11850	COG5433	transposase activity
GWG05_11855	COG3328	transposase activity
GWG05_11860	COG0210	DNA helicase
GWG05_11870	COG3039	Transposase
GWG05_11955	COG3550	peptidyl-serine autophosphorylation
GWG05_11965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWG05_11980	COG2723	6-phospho-beta-galactosidase activity
GWG05_11985	COG2190	(PTS) system
GWG05_11985	COG1263	PTS System
GWG05_11985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_11990	COG1737	Transcriptional regulator
GWG05_12010	COG1435	thymidine kinase activity
GWG05_12015	COG1757	Na H antiporter
GWG05_12020	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG05_12025	COG2096	Adenosyltransferase
GWG05_12030	COG3530	Putative quorum-sensing-regulated virulence factor
GWG05_12035	COG0602	queuosine metabolic process
GWG05_12040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWG05_12060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWG05_12070	COG0776	regulation of translation
GWG05_12075	COG0539	negative regulation of cytoplasmic translation
GWG05_12080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWG05_12085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG05_12110	COG0778	Nitroreductase
GWG05_12115	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWG05_12120	COG5001	Diguanylate cyclase
GWG05_12120	COG3300	MHYT domain
GWG05_12130	COG0583	DNA-binding transcription factor activity
GWG05_12135	COG0745	RESPONSE REGULATOR receiver
GWG05_12160	COG4989	oxidoreductase activity
GWG05_12165	COG0724	RNA recognition motif
GWG05_12175	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWG05_12185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWG05_12205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_12210	COG1360	Flagellar Motor Protein
GWG05_12215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_12220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_12225	COG0649	NAD binding
GWG05_12225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_12240	COG1034	ATP synthesis coupled electron transport
GWG05_12245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWG05_12250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_12255	COG0839	Belongs to the complex I subunit 6 family
GWG05_12260	COG0713	ATP synthesis coupled electron transport
GWG05_12270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_12275	COG1007	ATP synthesis coupled electron transport
GWG05_12280	COG0047	phosphoribosylformylglycinamidine synthase activity
GWG05_12280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWG05_12285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG05_12295	COG1645	bacterial-type flagellum-dependent swarming motility
GWG05_12300	COG1160	GTP binding
GWG05_12305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_12310	COG2976	Protein conserved in bacteria
GWG05_12315	COG0124	histidyl-tRNA synthetase
GWG05_12325	COG1426	Protein conserved in bacteria
GWG05_12335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWG05_12340	COG0105	UTP biosynthetic process
GWG05_12355	COG0633	Ferredoxin
GWG05_12360	COG0443	Heat shock 70 kDa protein
GWG05_12365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG05_12375	COG0822	iron-sulfur transferase activity
GWG05_12380	COG1104	cysteine desulfurase activity
GWG05_12395	COG3154	lipid carrier protein
GWG05_12400	COG0826	peptidase U32
GWG05_12405	COG0826	peptidase U32
GWG05_12415	COG2897	thiosulfate sulfurtransferase activity
GWG05_12420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_12425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_12430	COG1862	Preprotein translocase
GWG05_12435	COG0343	queuine tRNA-ribosyltransferase activity
GWG05_12440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWG05_12445	COG0517	IMP dehydrogenase activity
GWG05_12450	COG0450	alkyl hydroperoxide reductase
GWG05_12455	COG3634	alkyl hydroperoxide reductase activity
GWG05_12490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG05_12530	COG5642	Protein of unknown function (DUF2384)
GWG05_12555	COG5433	transposase activity
GWG05_12570	COG3039	Transposase
GWG05_12590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWG05_12595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWG05_12615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG05_12615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG05_12620	COG0509	glycine decarboxylation via glycine cleavage system
GWG05_12625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWG05_12630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_12635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_12655	COG2814	Major facilitator Superfamily
GWG05_12660	COG0444	Belongs to the ABC transporter superfamily
GWG05_12665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_12670	COG0601	transmembrane transport
GWG05_12680	COG0625	glutathione transferase activity
GWG05_12685	COG0625	glutathione transferase activity
GWG05_12695	COG0483	inositol monophosphate 1-phosphatase activity
GWG05_12710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_12715	COG2056	Na+-H+ antiporter family
GWG05_12720	COG2814	Major facilitator Superfamily
GWG05_12725	COG0583	DNA-binding transcription factor activity
GWG05_12730	COG5001	Diguanylate cyclase
GWG05_12745	COG2050	protein possibly involved in aromatic compounds catabolism
GWG05_12755	COG0247	lactate metabolic process
GWG05_12755	COG0277	FAD linked oxidase domain protein
GWG05_12770	COG1253	flavin adenine dinucleotide binding
GWG05_12775	COG1902	pentaerythritol trinitrate reductase activity
GWG05_12785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG05_12790	COG0647	UMP catabolic process
GWG05_12800	COG0367	asparagine synthase
GWG05_12815	COG0625	glutathione transferase activity
GWG05_12825	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWG05_12840	COG0564	pseudouridine synthase activity
GWG05_12845	COG5001	Diguanylate cyclase
GWG05_12855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWG05_12890	COG0670	Belongs to the BI1 family
GWG05_12895	COG1289	transmembrane transporter activity
GWG05_12900	COG2920	part of a sulfur-relay system
GWG05_12905	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWG05_12910	COG0285	dihydrofolate synthase activity
GWG05_12915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWG05_12920	COG0101	tRNA pseudouridine synthase activity
GWG05_12930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG05_12935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG05_12945	COG1464	Belongs to the NlpA lipoprotein family
GWG05_12975	COG1119	ATPase activity
GWG05_12980	COG0574	Belongs to the PEP-utilizing enzyme family
GWG05_12980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWG05_12985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWG05_12995	COG1113	amino acid transport
GWG05_13040	COG1242	4 iron, 4 sulfur cluster binding
GWG05_13045	COG0067	glutamate synthase
GWG05_13045	COG0069	glutamate synthase activity
GWG05_13045	COG0070	glutamate synthase
GWG05_13050	COG0493	'glutamate synthase
GWG05_13065	COG5433	transposase activity
GWG05_13075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_13100	COG4104	PAAR repeat-containing protein
GWG05_13110	COG0513	Belongs to the DEAD box helicase family
GWG05_13140	COG3706	GGDEF domain
GWG05_13145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG05_13150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWG05_13155	COG0505	Belongs to the CarA family
GWG05_13160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWG05_13170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWG05_13175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWG05_13180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG05_13185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWG05_13190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_13195	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWG05_13200	COG4139	cobalamin transport
GWG05_13225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWG05_13235	COG0023	Translation Initiation Factor
GWG05_13240	COG2119	membrane
GWG05_13275	COG2199	diguanylate cyclase activity
GWG05_13275	COG2203	Gaf domain
GWG05_13315	COG0215	cysteine-tRNA ligase activity
GWG05_13320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG05_13330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_13335	COG2261	transglycosylase associated protein
GWG05_13340	COG1309	transcriptional regulator
GWG05_13345	COG0604	alcohol dehydrogenase
GWG05_13360	COG0583	DNA-binding transcription factor activity
GWG05_13385	COG0322	excinuclease ABC activity
GWG05_13390	COG2197	response regulator
GWG05_13395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWG05_13400	COG2835	tetraacyldisaccharide 4'-kinase activity
GWG05_13405	COG1663	tetraacyldisaccharide 4'-kinase activity
GWG05_13410	COG1132	(ABC) transporter
GWG05_13415	COG2333	competence protein COMEC
GWG05_13415	COG0658	competence protein
GWG05_13430	COG0433	COG0433 Predicted ATPase
GWG05_13435	COG1448	Aminotransferase
GWG05_13450	COG1199	ATP-dependent helicase activity
GWG05_13460	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWG05_13465	COG0477	Major facilitator Superfamily
GWG05_13470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWG05_13475	COG1785	Belongs to the alkaline phosphatase family
GWG05_13495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG05_13500	COG3706	GGDEF domain
GWG05_13505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_13510	COG0765	amino acid transport
GWG05_13515	COG1126	abc transporter atp-binding protein
GWG05_13525	COG0531	amino acid
GWG05_13540	COG1253	flavin adenine dinucleotide binding
GWG05_13545	COG0704	Plays a role in the regulation of phosphate uptake
GWG05_13555	COG0581	inorganic phosphate transmembrane transporter activity
GWG05_13560	COG0573	inorganic phosphate transmembrane transporter activity
GWG05_13565	COG0590	tRNA wobble adenosine to inosine editing
GWG05_13575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWG05_13595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWG05_13600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWG05_13605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWG05_13610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWG05_13620	COG3852	Histidine kinase
GWG05_13635	COG2716	regulation of RNA biosynthetic process
GWG05_13640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWG05_13650	COG2239	Acts as a magnesium transporter
GWG05_13665	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWG05_13665	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWG05_13670	COG1706	bacterial-type flagellum-dependent cell motility
GWG05_13675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWG05_13690	COG1749	Flagellar hook protein flgE
GWG05_13705	COG1815	bacterial-type flagellum-dependent cell motility
GWG05_13710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWG05_13715	COG0835	chemotaxis
GWG05_13715	COG0784	Response regulator, receiver
GWG05_13720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GWG05_13735	COG0622	Phosphoesterase
GWG05_13740	COG4166	transmembrane transport
GWG05_13755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_13765	COG0697	spore germination
GWG05_13770	COG4166	transmembrane transport
GWG05_13795	COG1278	Cold shock
GWG05_13835	COG3132	Protein of unknown function, DUF480
GWG05_13850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_13870	COG0489	protein tyrosine kinase activity
GWG05_13870	COG3206	protein involved in exopolysaccharide biosynthesis
GWG05_13875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWG05_13880	COG1596	polysaccharide export
GWG05_13890	COG1215	transferase activity, transferring glycosyl groups
GWG05_13910	COG1215	transferase activity, transferring glycosyl groups
GWG05_13920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWG05_13930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG05_13945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWG05_13945	COG2755	lipolytic protein G-D-S-L family
GWG05_13975	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWG05_13985	COG0745	RESPONSE REGULATOR receiver
GWG05_14000	COG1737	Transcriptional regulator
GWG05_14005	COG0469	pyruvate kinase activity
GWG05_14015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_14020	COG1960	acyl-CoA dehydrogenase activity
GWG05_14030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWG05_14040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWG05_14050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_14060	COG1309	transcriptional regulator
GWG05_14075	COG1946	Acyl-CoA thioesterase
GWG05_14090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWG05_14100	COG0009	L-threonylcarbamoyladenylate synthase
GWG05_14105	COG0613	PHP domain protein
GWG05_14110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWG05_14115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG05_14115	COG0512	Glutamine amidotransferase of anthranilate synthase
GWG05_14120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG05_14125	COG0134	indole-3-glycerol-phosphate synthase activity
GWG05_14125	COG0135	phosphoribosylanthranilate isomerase activity
GWG05_14130	COG0133	tryptophan synthase activity
GWG05_14135	COG0159	tryptophan synthase activity
GWG05_14205	COG4521	taurine ABC transporter
GWG05_14210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWG05_14215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWG05_14220	COG2175	clavaminate synthase activity
GWG05_14225	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWG05_14230	COG2814	Major facilitator Superfamily
GWG05_14235	COG0109	protoheme IX farnesyltransferase activity
GWG05_14240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWG05_14245	COG1845	cytochrome c oxidase, subunit III
GWG05_14250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWG05_14255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG05_14260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG05_14265	COG0583	DNA-binding transcription factor activity
GWG05_14285	COG1846	Transcriptional regulator
GWG05_14300	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWG05_14315	COG0745	RESPONSE REGULATOR receiver
GWG05_14325	COG0708	Exodeoxyribonuclease III
GWG05_14335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_14340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_14355	COG0095	Lipoate-protein ligase
GWG05_14375	COG2391	methyltransferase activity
GWG05_14385	COG0640	Transcriptional regulator
GWG05_14395	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_14405	COG1285	pathogenesis
GWG05_14435	COG0484	heat shock protein binding
GWG05_14440	COG0443	Heat shock 70 kDa protein
GWG05_14445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWG05_14450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWG05_14455	COG3706	GGDEF domain
GWG05_14460	COG0497	DNA recombination
GWG05_14470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_14475	COG1136	(ABC) transporter
GWG05_14475	COG0577	efflux transmembrane transporter activity
GWG05_14485	COG2375	cellular response to nickel ion
GWG05_14490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_14495	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG05_14500	COG0583	DNA-binding transcription factor activity
GWG05_14505	COG3048	D-serine ammonia-lyase activity
GWG05_14515	COG0538	isocitrate dehydrogenase activity
GWG05_14545	COG0456	acetyltransferase
GWG05_14550	COG1187	pseudouridine synthase activity
GWG05_14560	COG0482	sulfurtransferase activity
GWG05_14565	COG2915	High frequency lysogenization protein hflD homolog
GWG05_14570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWG05_14575	COG2850	peptidyl-arginine hydroxylation
GWG05_14585	COG3264	Mechanosensitive ion channel
GWG05_14585	COG1196	nuclear chromosome segregation
GWG05_14615	COG0281	malic enzyme
GWG05_14620	COG0746	molybdenum cofactor guanylyltransferase activity
GWG05_14625	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWG05_14630	COG1289	transmembrane transporter activity
GWG05_14635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_14665	COG3220	belongs to the UPF0276 family
GWG05_14675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWG05_14700	COG0454	-acetyltransferase
GWG05_14715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG05_14720	COG0083	homoserine kinase activity
GWG05_14735	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWG05_14740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWG05_14755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG05_14765	COG0745	RESPONSE REGULATOR receiver
GWG05_14780	COG4988	ABC transporter
GWG05_14785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWG05_14805	COG1720	tRNA m6t6A37 methyltransferase activity
GWG05_14820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWG05_14825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWG05_14830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_14840	COG2190	(PTS) system
GWG05_14845	COG3038	cytochrome b561
GWG05_14855	COG0420	3'-5' exonuclease activity
GWG05_14860	COG1247	-acetyltransferase
GWG05_14865	COG2974	May be involved in recombination
GWG05_14875	COG0405	Gamma-glutamyltransferase
GWG05_14880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWG05_14880	COG4651	solute:proton antiporter activity
GWG05_14915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_14920	COG1917	Cupin 2, conserved barrel domain protein
GWG05_14920	COG1396	sequence-specific DNA binding
GWG05_14925	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_14935	COG0531	amino acid
GWG05_14940	COG0531	amino acid
GWG05_14950	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWG05_14960	COG3384	dioxygenase
GWG05_14965	COG2205	protein histidine kinase activity
GWG05_14965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_14990	COG2205	protein histidine kinase activity
GWG05_14990	COG0784	Response regulator, receiver
GWG05_15000	COG1376	ErfK ybiS ycfS ynhG family protein
GWG05_15000	COG1388	LysM domain
GWG05_15015	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWG05_15020	COG0791	NLP P60 protein
GWG05_15030	COG3118	belongs to the thioredoxin family
GWG05_15040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG05_15045	COG0788	formyltetrahydrofolate deformylase activity
GWG05_15070	COG0739	heme binding
GWG05_15070	COG0741	lytic transglycosylase activity
GWG05_15070	COG1196	nuclear chromosome segregation
GWG05_15080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG05_15085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWG05_15090	COG0673	inositol 2-dehydrogenase activity
GWG05_15120	COG1032	radical SAM domain protein
GWG05_15125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_15135	COG3706	GGDEF domain
GWG05_15140	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG05_15145	COG0733	neurotransmitter:sodium symporter activity
GWG05_15175	COG0281	malic enzyme
GWG05_15180	COG2207	Transcriptional regulator
GWG05_15200	COG2233	PERMEase
GWG05_15205	COG0095	Lipoate-protein ligase
GWG05_15210	COG1115	amino acid carrier protein
GWG05_15215	COG0019	diaminopimelate decarboxylase activity
GWG05_15225	COG0678	peroxiredoxin activity
GWG05_15230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWG05_15240	COG1126	abc transporter atp-binding protein
GWG05_15245	COG0765	amino acid transport
GWG05_15250	COG4597	amino acid ABC transporter
GWG05_15255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_15270	COG1131	(ABC) transporter
GWG05_15275	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG05_15295	COG3142	Participates in the control of copper homeostasis
GWG05_15300	COG1940	carbohydrate kinase activity
GWG05_15310	COG4783	chaperone-mediated protein folding
GWG05_15320	COG5002	protein histidine kinase activity
GWG05_15325	COG0745	RESPONSE REGULATOR receiver
GWG05_15330	COG0346	lactoylglutathione lyase activity
GWG05_15335	COG3706	GGDEF domain
GWG05_15340	COG3284	Transcriptional regulator
GWG05_15345	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_15355	COG0697	spore germination
GWG05_15365	COG0667	Aldo Keto reductase
GWG05_15380	COG3290	protein histidine kinase activity
GWG05_15390	COG1566	PFAM secretion protein HlyD family protein
GWG05_15415	COG0602	queuosine metabolic process
GWG05_15420	COG1328	CTP reductase activity
GWG05_15430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWG05_15435	COG3115	cell septum assembly
GWG05_15440	COG1196	nuclear chromosome segregation
GWG05_15450	COG2860	membrane
GWG05_15460	COG3108	Peptidase M15
GWG05_15465	COG2989	Protein conserved in bacteria
GWG05_15480	COG0463	Glycosyl transferase, family 2
GWG05_15495	COG0366	Alpha amylase catalytic
GWG05_15540	COG3706	GGDEF domain
GWG05_15545	COG0037	tRNA processing
GWG05_15560	COG0488	(ABC) transporter
GWG05_15570	COG0531	amino acid
GWG05_15575	COG0814	amino acid
GWG05_15590	COG0825	malonyl-CoA metabolic process
GWG05_15595	COG0587	DNA-directed DNA polymerase activity
GWG05_15600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWG05_15605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_15610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_15615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG05_15620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_15635	COG0750	zinc metalloprotease
GWG05_15640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWG05_15645	COG0575	Belongs to the CDS family
GWG05_15650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWG05_15655	COG0233	cytoplasmic translational termination
GWG05_15660	COG0528	UMP kinase activity
GWG05_15665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWG05_15670	COG0052	Belongs to the universal ribosomal protein uS2 family
GWG05_15675	COG0024	Methionine aminopeptidase
GWG05_15680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWG05_15685	COG2171	N-acyltransferase activity
GWG05_15695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_15695	COG1263	PTS System
GWG05_15720	COG0564	pseudouridine synthase activity
GWG05_15725	COG3098	single-species biofilm formation
GWG05_15750	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWG05_15760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG05_15760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG05_15770	COG3706	GGDEF domain
GWG05_15775	COG1611	Belongs to the LOG family
GWG05_15780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_15785	COG0473	3-isopropylmalate dehydrogenase activity
GWG05_15795	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWG05_15810	COG0583	DNA-binding transcription factor activity
GWG05_15815	COG0840	transmembrane signaling receptor activity
GWG05_15820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG05_15835	COG1477	protein flavinylation
GWG05_15840	COG2871	sodium ion transport
GWG05_15845	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_15850	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_15855	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_15860	COG1805	sodium ion transport
GWG05_15865	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_15870	COG0271	Belongs to the BolA IbaG family
GWG05_15875	COG2813	Specifically methylates the guanine in position
GWG05_15885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG05_15895	COG2211	Major facilitator Superfamily
GWG05_15900	COG3248	Nucleoside-binding outer membrane protein
GWG05_15905	COG1666	GTP binding
GWG05_15910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWG05_15920	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_15925	COG5002	protein histidine kinase activity
GWG05_15930	COG0745	RESPONSE REGULATOR receiver
GWG05_15935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_15940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_15955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_15965	COG1151	hydroxylamine reductase activity
GWG05_15970	COG0783	Belongs to the Dps family
GWG05_15995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWG05_16010	COG4221	oxidoreductase activity
GWG05_16020	COG0415	Belongs to the DNA photolyase family
GWG05_16025	COG0789	Transcriptional regulator
GWG05_16030	COG3272	Protein of unknown function (DUF1722)
GWG05_16055	COG1605	Chorismate mutase
GWG05_16055	COG0077	Prephenate dehydratase
GWG05_16085	COG2133	pyrroloquinoline quinone binding
GWG05_16095	COG1349	DNA-binding transcription factor activity
GWG05_16100	COG2084	Dehydrogenase
GWG05_16105	COG3395	kinase activity
GWG05_16110	COG0235	Class ii aldolase
GWG05_16115	COG3622	Belongs to the hyi family
GWG05_16120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG05_16125	COG2610	gluconate transmembrane transporter activity
GWG05_16135	COG0840	transmembrane signaling receptor activity
GWG05_16145	COG0300	oxidoreductase activity
GWG05_16170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWG05_16190	COG3813	Protein conserved in bacteria
GWG05_16200	COG0826	peptidase U32
GWG05_16205	COG1280	lysine exporter protein (LysE YggA)
GWG05_16240	COG2199	diguanylate cyclase activity
GWG05_16240	COG2200	EAL domain
GWG05_16240	COG2203	Gaf domain
GWG05_16285	COG1566	PFAM secretion protein HlyD family protein
GWG05_16295	COG0114	fumarate hydratase activity
GWG05_16305	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG05_16305	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG05_16305	COG0506	proline dehydrogenase activity
GWG05_16310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG05_16325	COG0737	Belongs to the 5'-nucleotidase family
GWG05_16345	COG2204	response regulator
GWG05_16350	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG05_16360	COG2900	Belongs to the SlyX family
GWG05_16365	COG1047	Peptidyl-prolyl cis-trans
GWG05_16370	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWG05_16380	COG0784	Response regulator, receiver
GWG05_16380	COG0835	chemotaxis
GWG05_16385	COG0429	hydrolase of the alpha beta-hydrolase fold
GWG05_16390	COG5001	Diguanylate cyclase
GWG05_16390	COG4251	negative regulation of phosphorylation
GWG05_16390	COG3706	GGDEF domain
GWG05_16390	COG2203	Gaf domain
GWG05_16395	COG3089	Belongs to the UPF0270 family
GWG05_16400	COG3954	Phosphoribulokinase
GWG05_16415	COG1765	OsmC-like protein
GWG05_16425	COG2226	methyltransferase
GWG05_16435	COG2205	protein histidine kinase activity
GWG05_16435	COG2202	Pas domain
GWG05_16440	COG2814	Major facilitator Superfamily
GWG05_16465	COG0748	coenzyme F420 binding
GWG05_16470	COG3721	Heme iron utilization protein
GWG05_16480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_16505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWG05_16515	COG0463	Glycosyl transferase, family 2
GWG05_16520	COG0741	lytic transglycosylase activity
GWG05_16525	COG0488	(ABC) transporter
GWG05_16535	COG2252	PERMEase
GWG05_16540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG05_16545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWG05_16550	COG3178	'Phosphotransferase
GWG05_16555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWG05_16570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWG05_16575	COG2967	ApaG domain
GWG05_16580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG05_16590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWG05_16595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_16605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWG05_16610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWG05_16615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWG05_16620	COG0142	geranyltranstransferase activity
GWG05_16625	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWG05_16630	COG0330	HflC and HflK could
GWG05_16635	COG0330	HflC and HflK could
GWG05_16640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWG05_16645	COG1923	regulation of RNA biosynthetic process
GWG05_16650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWG05_16655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWG05_16665	COG0802	atpase or kinase
GWG05_16670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWG05_16670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWG05_16690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG05_16695	COG2011	ABC-type metal ion transport system permease component
GWG05_16700	COG1464	Belongs to the NlpA lipoprotein family
GWG05_16735	COG5002	protein histidine kinase activity
GWG05_16735	COG2198	Histidine kinase
GWG05_16735	COG0784	Response regulator, receiver
GWG05_16755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWG05_16770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWG05_16775	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWG05_16780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG05_16785	COG2716	regulation of RNA biosynthetic process
GWG05_16790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWG05_16795	COG3013	Belongs to the UPF0304 family
GWG05_16805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWG05_16810	COG0280	phosphate acetyltransferase
GWG05_16810	COG0857	belongs to the CobB CobQ family
GWG05_16815	COG0440	acetolactate synthase activity
GWG05_16825	COG0028	Belongs to the TPP enzyme family
GWG05_16840	COG0671	phosphoesterase, PA-phosphatase related
GWG05_16850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG05_16855	COG0473	3-isopropylmalate dehydrogenase activity
GWG05_16860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWG05_16865	COG0066	3-isopropylmalate dehydratase activity
GWG05_16880	COG4143	(ABC) transporter
GWG05_16885	COG1178	ABC-type Fe3 transport system permease component
GWG05_16890	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWG05_16895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWG05_16905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_16935	COG0316	Belongs to the HesB IscA family
GWG05_16945	COG0038	chloride channel
GWG05_16950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWG05_16965	COG0671	phosphoesterase, PA-phosphatase related
GWG05_16975	COG0583	DNA-binding transcription factor activity
GWG05_16980	COG2076	Multidrug Resistance protein
GWG05_16990	COG0346	lactoylglutathione lyase activity
GWG05_16995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG05_17000	COG1643	Atp-dependent helicase
GWG05_17010	COG1489	DNA binding
GWG05_17015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWG05_17020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_17030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWG05_17035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWG05_17040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWG05_17050	COG0842	Transport permease protein
GWG05_17055	COG1131	(ABC) transporter
GWG05_17070	COG0163	prenyltransferase activity
GWG05_17075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG05_17080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWG05_17095	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWG05_17110	COG1136	(ABC) transporter
GWG05_17160	COG0529	Catalyzes the synthesis of activated sulfate
GWG05_17165	COG0471	metal ion transport
GWG05_17165	COG3273	potassium ion transport
GWG05_17170	COG2895	sulfate adenylyltransferase (ATP) activity
GWG05_17175	COG0175	sulfate reduction
GWG05_17180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_17180	COG1648	precorrin-2 dehydrogenase activity
GWG05_17185	COG0330	HflC and HflK could
GWG05_17190	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWG05_17200	COG0673	inositol 2-dehydrogenase activity
GWG05_17210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWG05_17215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWG05_17220	COG3036	rescue of stalled ribosome
GWG05_17235	COG0138	bifunctional purine biosynthesis protein purh
GWG05_17285	COG3039	Transposase
GWG05_17315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWG05_17320	COG0358	DNA primase activity
GWG05_17325	COG1610	YqeY-like protein
GWG05_17330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWG05_17335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWG05_17345	COG1388	LysM domain
GWG05_17345	COG4942	peptidase
GWG05_17350	COG1238	metal cluster binding
GWG05_17355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWG05_17360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWG05_17365	COG0585	pseudouridine synthase activity
GWG05_17370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWG05_17375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWG05_17380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWG05_17385	COG0148	phosphopyruvate hydratase activity
GWG05_17390	COG0504	CTP synthase activity
GWG05_17395	COG3956	TIGRFAM MazG family protein
GWG05_17400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG05_17405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_17415	COG4807	Protein conserved in bacteria
GWG05_17420	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWG05_17425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWG05_17430	COG1381	Involved in DNA repair and RecF pathway recombination
GWG05_17440	COG0571	ribonuclease III activity
GWG05_17445	COG0681	Belongs to the peptidase S26 family
GWG05_17450	COG0481	GTPase activity
GWG05_17465	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GWG05_17470	COG1595	DNA-templated transcription, initiation
GWG05_17475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWG05_17485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWG05_17495	COG0583	DNA-binding transcription factor activity
GWG05_17525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_17535	COG0126	phosphoglycerate kinase activity
GWG05_17540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG05_17545	COG1940	carbohydrate kinase activity
GWG05_17550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWG05_17555	COG2816	NAD+ diphosphatase activity
GWG05_17560	COG4991	sh3 domain protein
GWG05_17565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG05_17580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWG05_17585	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_17595	COG1505	serine-type exopeptidase activity
GWG05_17600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG05_17605	COG0765	amino acid transport
GWG05_17610	COG0765	amino acid transport
GWG05_17615	COG1126	abc transporter atp-binding protein
GWG05_17620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_17625	COG3174	membrane
GWG05_17630	COG0110	maltose O-acetyltransferase activity
GWG05_17660	COG1942	4-Oxalocrotonate Tautomerase
GWG05_17670	COG0583	DNA-binding transcription factor activity
GWG05_17675	COG0165	Argininosuccinate lyase
GWG05_17680	COG0137	argininosuccinate synthase activity
GWG05_17690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG05_17695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWG05_17705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWG05_17710	COG3447	MASE1 domain protein
GWG05_17710	COG5002	protein histidine kinase activity
GWG05_17710	COG5001	Diguanylate cyclase
GWG05_17715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWG05_17755	COG0583	DNA-binding transcription factor activity
GWG05_17760	COG1380	Effector of murein hydrolase LrgA
GWG05_17765	COG1346	cytolysis
GWG05_17770	COG0460	homoserine dehydrogenase
GWG05_17770	COG0527	aspartate kinase activity
GWG05_17775	COG0626	cystathionine gamma-synthase activity
GWG05_17790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_17795	COG0814	amino acid
GWG05_17800	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWG05_17805	COG0494	nUDIX hydrolase
GWG05_17810	COG1011	Hydrolase
GWG05_17825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG05_17840	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWG05_17850	COG3156	type II secretion system protein K
GWG05_17860	COG4795	General secretion pathway protein
GWG05_17865	COG2165	general secretion pathway protein
GWG05_17875	COG2165	general secretion pathway protein
GWG05_17880	COG1459	type II secretion system
GWG05_17885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG05_17895	COG3031	protein transport across the cell outer membrane
GWG05_17905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWG05_17910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWG05_17930	COG3133	Outer membrane lipoprotein
GWG05_17935	COG3025	triphosphatase activity
GWG05_17940	COG1392	Phosphate transport regulator
GWG05_17945	COG0306	phosphate transporter
GWG05_17950	COG0617	tRNA 3'-terminal CCA addition
GWG05_17955	COG3267	Type II secretory pathway component ExeA
GWG05_17955	COG3409	Peptidoglycan-binding domain 1 protein
GWG05_17965	COG1194	a g-specific adenine glycosylase
GWG05_17970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWG05_17985	COG3240	lipase activity
GWG05_17995	COG3009	Protein conserved in bacteria
GWG05_18000	COG3008	intermembrane lipid transfer
GWG05_18000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG05_18005	COG2995	paraquat-inducible protein a
GWG05_18015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_18020	COG2203	Gaf domain
GWG05_18020	COG3706	GGDEF domain
GWG05_18020	COG4251	negative regulation of phosphorylation
GWG05_18020	COG5001	Diguanylate cyclase
GWG05_18025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG05_18030	COG2813	Specifically methylates the guanine in position
GWG05_18035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWG05_18040	COG0297	glycogen (starch) synthase activity
GWG05_18080	COG1757	Na H antiporter
GWG05_18095	COG3842	ATPase activity
GWG05_18100	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG05_18105	COG1177	transmembrane transport
GWG05_18110	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_18115	COG0109	protoheme IX farnesyltransferase activity
GWG05_18145	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWG05_18155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG05_18155	COG1565	acr, cog1565
GWG05_18160	COG1444	tRNA N-acetyltransferase activity
GWG05_18180	COG1803	Methylglyoxal synthase
GWG05_18195	COG0252	asparaginase activity
GWG05_18215	COG1263	PTS System
GWG05_18215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_18220	COG0366	Alpha amylase catalytic
GWG05_18225	COG0110	maltose O-acetyltransferase activity
GWG05_18230	COG1522	sequence-specific DNA binding
GWG05_18260	COG3068	Protein conserved in bacteria
GWG05_18270	COG0739	heme binding
GWG05_18290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWG05_18295	COG1121	(ABC) transporter
GWG05_18300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWG05_18305	COG0583	DNA-binding transcription factor activity
GWG05_18315	COG1573	uracil-dna glycosylase
GWG05_18320	COG2962	Rard protein
GWG05_18325	COG2827	Endonuclease containing a URI domain
GWG05_18340	COG1842	Phage shock protein A
GWG05_18345	COG0204	Acyl-transferase
GWG05_18365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_18375	COG0484	heat shock protein binding
GWG05_18420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWG05_18455	COG1289	transmembrane transporter activity
GWG05_18460	COG1566	PFAM secretion protein HlyD family protein
GWG05_18475	COG1051	belongs to the nudix hydrolase family
GWG05_18480	COG3150	esterase
GWG05_18490	COG3151	Protein conserved in bacteria
GWG05_18495	COG0494	nUDIX hydrolase
GWG05_18500	COG1538	Outer membrane efflux protein
GWG05_18505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWG05_18505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWG05_18510	COG1560	Kdo2-lipid A biosynthetic process
GWG05_18525	COG2771	luxR family
GWG05_18530	COG3916	Acyl-homoserine-lactone synthase
GWG05_18540	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWG05_18545	COG2213	PTS system mannitol-specific
GWG05_18545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_18550	COG0246	Mannitol dehydrogenase
GWG05_18555	COG3722	fumarate hydratase activity
GWG05_18560	COG3263	regulation of cellular component size
GWG05_18580	COG1671	Belongs to the UPF0178 family
GWG05_18600	COG5433	transposase activity
GWG05_18620	COG0513	Belongs to the DEAD box helicase family
GWG05_18640	COG1575	Belongs to the MenA family. Type 1 subfamily
GWG05_18645	COG1169	isochorismate synthase
GWG05_18650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWG05_18655	COG0596	Alpha beta hydrolase
GWG05_18660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWG05_18670	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_18675	COG3291	Pkd domain containing protein
GWG05_18680	COG2949	membrane
GWG05_18685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWG05_18695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWG05_18725	COG2873	o-acetylhomoserine
GWG05_18735	COG1979	alcohol dehydrogenase
GWG05_18750	COG4221	oxidoreductase activity
GWG05_18770	COG1285	pathogenesis
GWG05_18785	COG1368	sulfuric ester hydrolase activity
GWG05_18790	COG1522	sequence-specific DNA binding
GWG05_18800	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWG05_18810	COG1546	Belongs to the CinA family
GWG05_18810	COG1058	Belongs to the CinA family
GWG05_18815	COG1988	membrane-bound metal-dependent
GWG05_18830	COG0561	phosphatase activity
GWG05_18835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWG05_18845	COG1011	Hydrolase
GWG05_18860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWG05_18865	COG0019	diaminopimelate decarboxylase activity
GWG05_18875	COG1965	Belongs to the frataxin family
GWG05_18880	COG0400	carboxylic ester hydrolase activity
GWG05_18885	COG3072	Adenylate cyclase
GWG05_18890	COG0181	hydroxymethylbilane synthase activity
GWG05_18900	COG2959	enzyme of heme biosynthesis
GWG05_18905	COG3071	HemY protein
GWG05_18910	COG0312	modulator of DNA gyrase
GWG05_18915	COG3028	Belongs to the UPF0307 family
GWG05_18925	COG2926	Belongs to the UPF0265 family
GWG05_18960	COG1396	sequence-specific DNA binding
GWG05_18965	COG3135	benzoate transporter
GWG05_18995	COG3047	cAMP biosynthetic process
GWG05_19000	COG5433	transposase activity
GWG05_19005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWG05_19010	COG2197	response regulator
GWG05_19035	COG1278	Cold shock
GWG05_19040	COG2205	protein histidine kinase activity
GWG05_19045	COG0745	RESPONSE REGULATOR receiver
GWG05_19065	COG3706	GGDEF domain
GWG05_19070	COG0347	Belongs to the P(II) protein family
GWG05_19075	COG0004	ammonium transporteR
GWG05_19085	COG0346	lactoylglutathione lyase activity
GWG05_19100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWG05_19105	COG1074	ATP-dependent DNA helicase activity
GWG05_19110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWG05_19115	COG2259	Doxx family
GWG05_19120	COG1741	Belongs to the pirin family
GWG05_19130	COG0583	DNA-binding transcription factor activity
GWG05_19155	COG1175	transmembrane transport
GWG05_19165	COG3842	ATPase activity
GWG05_19195	COG0456	acetyltransferase
GWG05_19200	COG0753	catalase activity
GWG05_19220	COG0494	nUDIX hydrolase
GWG05_19225	COG0628	permease
GWG05_19235	COG2957	Belongs to the agmatine deiminase family
GWG05_19250	COG2957	Belongs to the agmatine deiminase family
GWG05_19255	COG0583	DNA-binding transcription factor activity
GWG05_19270	COG1461	Dihydroxyacetone kinase
GWG05_19275	COG2376	Dihydroxyacetone kinase
GWG05_19280	COG2252	PERMEase
GWG05_19285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWG05_19320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG05_19325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG05_19330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWG05_19335	COG0049	tRNA binding
GWG05_19340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWG05_19345	COG2168	tRNA wobble position uridine thiolation
GWG05_19355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG05_19360	COG0251	oxidation-reduction process
GWG05_19365	COG2964	Protein conserved in bacteria
GWG05_19370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWG05_19375	COG0085	RNA polymerase activity
GWG05_19380	COG0222	ribosome binding
GWG05_19385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWG05_19390	COG0081	regulation of translation
GWG05_19395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWG05_19400	COG0250	Participates in transcription elongation, termination and antitermination
GWG05_19415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG05_19440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWG05_19445	COG0569	domain protein
GWG05_19450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_19455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWG05_19460	COG3005	denitrification pathway
GWG05_19465	COG0243	molybdopterin cofactor binding
GWG05_19480	COG0745	RESPONSE REGULATOR receiver
GWG05_19500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWG05_19515	COG2204	response regulator
GWG05_19525	COG2205	protein histidine kinase activity
GWG05_19545	COG0517	IMP dehydrogenase activity
GWG05_19545	COG0516	GMP reductase activity
GWG05_19555	COG1522	sequence-specific DNA binding
GWG05_19560	COG2502	aspartate--ammonia ligase
GWG05_19575	COG0583	DNA-binding transcription factor activity
GWG05_19580	COG0542	response to heat
GWG05_19590	COG0564	pseudouridine synthase activity
GWG05_19595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_19600	COG3681	Belongs to the UPF0597 family
GWG05_19610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWG05_19615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWG05_19620	COG1979	alcohol dehydrogenase
GWG05_19625	COG2207	Transcriptional regulator
GWG05_19630	COG3040	lipid binding
GWG05_19640	COG0840	transmembrane signaling receptor activity
GWG05_19650	COG0583	DNA-binding transcription factor activity
GWG05_19670	COG0540	Belongs to the ATCase OTCase family
GWG05_19675	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWG05_19680	COG1438	arginine binding
GWG05_19685	COG1288	antiporter activity
GWG05_19690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWG05_19725	COG3250	beta-galactosidase activity
GWG05_19730	COG1609	Transcriptional regulator
GWG05_19735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_19745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG05_19750	COG2017	converts alpha-aldose to the beta-anomer
GWG05_19755	COG0667	Aldo Keto reductase
GWG05_19760	COG1968	undecaprenyl-diphosphatase activity
GWG05_19765	COG3806	Anti-sigma factor
GWG05_19770	COG1595	DNA-templated transcription, initiation
GWG05_19790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWG05_19795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWG05_19800	COG0477	Major facilitator Superfamily
GWG05_19805	COG0583	DNA-binding transcription factor activity
GWG05_19815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_19820	COG1131	(ABC) transporter
GWG05_19825	COG0842	Transport permease protein
GWG05_19830	COG0842	Transport permease protein
GWG05_19835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_19845	COG2116	formate transmembrane transporter activity
GWG05_19850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_19850	COG1648	precorrin-2 dehydrogenase activity
GWG05_19855	COG2239	Acts as a magnesium transporter
GWG05_19860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG05_19865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWG05_19875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWG05_19885	COG0514	ATP-dependent DNA helicase (RecQ)
GWG05_19890	COG2050	protein possibly involved in aromatic compounds catabolism
GWG05_19905	COG2258	MOSC domain
GWG05_19910	COG1177	transmembrane transport
GWG05_19915	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG05_19920	COG3842	ATPase activity
GWG05_19940	COG0174	glutamine synthetase
GWG05_19960	COG3045	CreA protein
GWG05_19965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG05_19970	COG0443	Heat shock 70 kDa protein
GWG05_19985	COG0366	Alpha amylase catalytic
GWG05_20000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_20005	COG0745	RESPONSE REGULATOR receiver
GWG05_20015	COG2205	protein histidine kinase activity
GWG05_20025	COG0281	malic enzyme
GWG05_20030	COG0702	epimerase
GWG05_20035	COG0254	rRNA binding
GWG05_20040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWG05_20045	COG3039	Transposase
GWG05_20060	COG0129	dihydroxy-acid dehydratase activity
GWG05_20070	COG3978	acetolactate synthase activity
GWG05_20085	COG0606	chelatase, subunit chli
GWG05_20090	COG0204	Acyl-transferase
GWG05_20095	COG0204	Acyl-transferase
GWG05_20100	COG1683	Conserved Protein
GWG05_20110	COG1335	isochorismatase
GWG05_20120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWG05_20125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWG05_20135	COG3084	Protein conserved in bacteria
GWG05_20140	COG4251	negative regulation of phosphorylation
GWG05_20140	COG3706	GGDEF domain
GWG05_20140	COG2203	Gaf domain
GWG05_20140	COG5001	Diguanylate cyclase
GWG05_20155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWG05_20160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWG05_20165	COG1561	YicC-like family, N-terminal region
GWG05_20175	COG1519	Transferase
GWG05_20180	COG0859	PFAM glycosyl transferase family 9
GWG05_20185	COG0463	Glycosyl transferase, family 2
GWG05_20190	COG0859	PFAM glycosyl transferase family 9
GWG05_20195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWG05_20200	COG2990	Protein conserved in bacteria
GWG05_20205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWG05_20215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWG05_20220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWG05_20225	COG2003	Belongs to the UPF0758 family
GWG05_20230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWG05_20235	COG0756	dUTP diphosphatase activity
GWG05_20240	COG1309	transcriptional regulator
GWG05_20250	COG0668	transmembrane transport
GWG05_20260	COG0166	Belongs to the GPI family
GWG05_20265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWG05_20270	COG0583	DNA-binding transcription factor activity
GWG05_20280	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG05_20280	COG1042	CoA-binding domain protein
GWG05_20280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_20305	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWG05_20310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_20315	COG1739	Uncharacterized protein family UPF0029
GWG05_20320	COG0006	proline dipeptidase activity
GWG05_20325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG05_20330	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG05_20330	COG1024	Enoyl-CoA hydratase
GWG05_20335	COG0183	Belongs to the thiolase family
GWG05_20340	COG0745	RESPONSE REGULATOR receiver
GWG05_20375	COG0425	Belongs to the sulfur carrier protein TusA family
GWG05_20380	COG0251	oxidation-reduction process
GWG05_20400	COG2885	chlorophyll binding
GWG05_20410	COG1335	isochorismatase
GWG05_20415	COG2818	Glycosylase
GWG05_20420	COG0752	glycyl-tRNA synthetase alpha subunit
GWG05_20425	COG0751	glycine-tRNA ligase activity
GWG05_20440	COG5001	Diguanylate cyclase
GWG05_20440	COG3706	GGDEF domain
GWG05_20440	COG2203	Gaf domain
GWG05_20440	COG4251	negative regulation of phosphorylation
GWG05_20465	COG0814	amino acid
GWG05_20470	COG0814	amino acid
GWG05_20475	COG3033	Beta-eliminating lyase
GWG05_20485	COG0348	domain, Protein
GWG05_20495	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_20500	COG1773	rubredoxin
GWG05_20500	COG0426	domain, Protein
GWG05_20505	COG3604	Transcriptional regulator
GWG05_20510	COG1609	Transcriptional regulator
GWG05_20550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_20565	COG2960	long-chain fatty acid transporting porin activity
GWG05_20575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWG05_20590	COG3118	belongs to the thioredoxin family
GWG05_20595	COG0513	Belongs to the DEAD box helicase family
GWG05_20600	COG0248	Ppx GppA phosphatase
GWG05_20610	COG0742	ribosomal rna small subunit methyltransferase
GWG05_20630	COG0084	hydrolase, TatD family'
GWG05_20635	COG0805	protein transport
GWG05_20640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_20645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_20650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWG05_20655	COG3165	ubiquinone biosynthetic process from chorismate
GWG05_20665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWG05_20670	COG0402	S-adenosylhomocysteine deaminase activity
GWG05_20710	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWG05_20715	COG0848	biopolymer transport protein
GWG05_20720	COG0811	peptide transport
GWG05_20725	COG0811	peptide transport
GWG05_20735	COG2771	luxR family
GWG05_20750	COG1349	DNA-binding transcription factor activity
GWG05_20760	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_20795	COG0166	Belongs to the GPI family
GWG05_20800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_20870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWG05_20875	COG1349	DNA-binding transcription factor activity
GWG05_20880	COG0745	RESPONSE REGULATOR receiver
GWG05_20885	COG2205	protein histidine kinase activity
GWG05_20895	COG4452	Inner membrane protein CreD
GWG05_20900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWG05_20905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWG05_20910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWG05_20915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWG05_20920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWG05_20925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWG05_20930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWG05_20940	COG0356	it plays a direct role in the translocation of protons across the membrane
GWG05_20950	COG1475	DNA binding
GWG05_20955	COG1192	Involved in chromosome partitioning
GWG05_20960	COG0357	Ribosomal RNA small subunit methyltransferase G
GWG05_20965	COG0445	tRNA wobble uridine modification
GWG05_20970	COG0716	FMN binding
GWG05_20975	COG4774	siderophore transport
GWG05_20980	COG4615	Cyclic peptide transporter
GWG05_20985	COG1120	ATPase activity
GWG05_20990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG05_21000	COG3550	peptidyl-serine autophosphorylation
GWG05_21025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWG05_21030	COG0706	membrane insertase activity
GWG05_21035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWG05_21040	COG0594	ribonuclease P activity
GWG05_21045	COG0230	Belongs to the bacterial ribosomal protein bL34 family