locus-tag	class	description
MF133_00010	COG1620	l-lactate permease
MF133_00140	COG0672	)-iron permease
MF133_00180	COG2308	Evidence 4 Homologs of previously reported genes of
MF133_00200	COG0659	secondary active sulfate transmembrane transporter activity
MF133_00230	COG3501	Rhs element vgr protein
MF133_00240	COG3209	COG3209 Rhs family protein
MF133_00300	COG3829	transcription factor binding
MF133_00335	COG3179	chitinase
MF133_00345	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MF133_00350	COG0437	4 iron, 4 sulfur cluster binding
MF133_00355	COG5557	Pfam Polysulphide reductase, NrfD
MF133_00360	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MF133_00365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MF133_00370	COG1773	rubredoxin
MF133_00380	COG0601	transmembrane transport
MF133_00385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF133_00395	COG3842	ATPase activity
MF133_00400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MF133_00410	COG0375	protein maturation
MF133_00415	COG0309	Hydrogenase expression formation protein (HypE)
MF133_00425	COG0298	carbon dioxide binding
MF133_00430	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MF133_00435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MF133_00440	COG0326	Molecular chaperone. Has ATPase activity
MF133_00445	COG0563	adenylate kinase activity
MF133_00450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MF133_00455	COG3788	relative of glutathione S-transferase, MAPEG superfamily
MF133_00460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF133_00465	COG0840	transmembrane signaling receptor activity
MF133_00480	COG5001	Diguanylate cyclase
MF133_00480	COG3300	MHYT domain
MF133_00505	COG1021	2,3-dihydroxybenzoate-AMP ligase
MF133_00510	COG3433	isochorismatase activity
MF133_00510	COG1535	isochorismatase
MF133_00515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MF133_00520	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_00530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MF133_00545	COG1120	ATPase activity
MF133_00550	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF133_00555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF133_00560	COG4771	TonB-dependent receptor
MF133_00600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MF133_00605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MF133_00610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF133_00615	COG0861	Integral membrane protein TerC family
MF133_00630	COG1022	Amp-dependent synthetase and ligase
MF133_00635	COG0295	cytidine deaminase activity
MF133_00640	COG1346	cytolysis
MF133_00645	COG1380	Effector of murein hydrolase LrgA
MF133_00650	COG3345	alpha-galactosidase
MF133_00660	COG2925	Exonuclease
MF133_00665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MF133_00670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MF133_00670	COG0392	lysyltransferase activity
MF133_00685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF133_00690	COG0436	Aminotransferase
MF133_00700	COG2160	L-arabinose isomerase activity
MF133_00710	COG1069	ribulokinase activity
MF133_00715	COG1879	ABC-type sugar transport system periplasmic component
MF133_00720	COG1129	ABC transporter
MF133_00725	COG1172	Belongs to the binding-protein-dependent transport system permease family
MF133_00735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MF133_00740	COG0254	rRNA binding
MF133_00755	COG1451	nucleotide metabolic process
MF133_00770	COG3069	C4-dicarboxylate transmembrane transporter activity
MF133_00780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MF133_00780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF133_00785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MF133_00805	COG2009	succinate dehydrogenase
MF133_00810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MF133_00825	COG0567	Dehydrogenase, E1 component
MF133_00830	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF133_00835	COG0045	succinate-CoA ligase (ADP-forming) activity
MF133_00840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MF133_00850	COG2983	Belongs to the UPF0260 family
MF133_00855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF133_00865	COG3842	ATPase activity
MF133_00870	COG1840	ABC-type Fe3 transport system, periplasmic component
MF133_00880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MF133_00885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MF133_00890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF133_00895	COG1882	Formate acetyltransferase
MF133_00900	COG2116	formate transmembrane transporter activity
MF133_00905	COG1944	ATP diphosphatase activity
MF133_00915	COG2076	Multidrug Resistance protein
MF133_00920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MF133_00925	COG1278	Cold shock
MF133_00930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MF133_00935	COG0542	response to heat
MF133_00940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MF133_00945	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MF133_00950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MF133_00955	COG3134	Outer membrane lipoprotein
MF133_00960	COG3706	GGDEF domain
MF133_00965	COG0492	ferredoxin-NADP+ reductase activity
MF133_00970	COG0686	Belongs to the AlaDH PNT family
MF133_00980	COG0531	amino acid
MF133_00980	COG1674	ftsk spoiiie
MF133_00985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MF133_00990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MF133_00995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MF133_01000	COG1286	toxin biosynthetic process
MF133_01005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MF133_01010	COG2723	6-phospho-beta-galactosidase activity
MF133_01015	COG1263	PTS System
MF133_01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_01020	COG1609	Transcriptional regulator
MF133_01030	COG4172	Belongs to the ABC transporter superfamily
MF133_01040	COG4171	peptide transport system, permease
MF133_01055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MF133_01060	COG1842	Phage shock protein A
MF133_01075	COG3106	COG3106 Predicted ATPase
MF133_01080	COG3768	UPF0283 membrane protein
MF133_01090	COG2154	pterin-4-alpha-carbinolamine dehydratase
MF133_01110	COG2885	chlorophyll binding
MF133_01120	COG1570	exodeoxyribonuclease VII activity
MF133_01145	COG1874	Beta-galactosidase
MF133_01145	COG0366	Alpha amylase catalytic
MF133_01155	COG0517	IMP dehydrogenase activity
MF133_01155	COG0516	GMP reductase activity
MF133_01160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MF133_01160	COG0519	Catalyzes the synthesis of GMP from XMP
MF133_01165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MF133_01195	COG1846	Transcriptional regulator
MF133_01215	COG2062	phosphohistidine phosphatase, SixA
MF133_01225	COG0697	spore germination
MF133_01235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MF133_01240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MF133_01250	COG4591	ABC-type transport system involved in lipoprotein release permease component
MF133_01255	COG1136	(ABC) transporter
MF133_01260	COG4591	ABC-type transport system involved in lipoprotein release permease component
MF133_01265	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MF133_01275	COG0544	peptidyl-prolyl cis-trans isomerase activity
MF133_01280	COG0740	serine-type endopeptidase activity
MF133_01285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MF133_01290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MF133_01295	COG0776	regulation of translation
MF133_01300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF133_01305	COG0488	(ABC) transporter
MF133_01310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF133_01315	COG3162	membrane
MF133_01330	COG1024	Enoyl-CoA hydratase
MF133_01335	COG1115	amino acid carrier protein
MF133_01345	COG3228	Belongs to the MtfA family
MF133_01350	COG1584	GPR1 FUN34 yaaH family protein
MF133_01375	COG1024	Enoyl-CoA hydratase
MF133_01375	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF133_01380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MF133_01385	COG1960	acyl-CoA dehydrogenase activity
MF133_01395	COG1960	acyl-CoA dehydrogenase activity
MF133_01400	COG1024	Enoyl-CoA hydratase
MF133_01405	COG1024	Enoyl-CoA hydratase
MF133_01415	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_01425	COG0730	response to heat
MF133_01460	COG1172	Belongs to the binding-protein-dependent transport system permease family
MF133_01465	COG1172	Belongs to the binding-protein-dependent transport system permease family
MF133_01470	COG1129	ABC transporter
MF133_01475	COG1879	ABC-type sugar transport system periplasmic component
MF133_01480	COG0583	DNA-binding transcription factor activity
MF133_01495	COG0583	DNA-binding transcription factor activity
MF133_01500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MF133_01505	COG0243	molybdopterin cofactor binding
MF133_01515	COG0583	DNA-binding transcription factor activity
MF133_01520	COG2723	6-phospho-beta-galactosidase activity
MF133_01530	COG0583	DNA-binding transcription factor activity
MF133_01545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MF133_01550	COG0673	inositol 2-dehydrogenase activity
MF133_01555	COG0583	DNA-binding transcription factor activity
MF133_01565	COG1560	Kdo2-lipid A biosynthetic process
MF133_01570	COG1560	Kdo2-lipid A biosynthetic process
MF133_01585	COG0417	DNA replication proofreading
MF133_01615	COG0534	Mate efflux family protein
MF133_01625	COG0307	riboflavin synthase, alpha
MF133_01640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF133_01645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MF133_01650	COG0697	spore germination
MF133_01655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MF133_01680	COG2996	Protein conserved in bacteria
MF133_01695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF133_01700	COG3099	Belongs to the UPF0263 family
MF133_01705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MF133_01710	COG2894	cell division
MF133_01715	COG0850	regulation of cytokinetic process
MF133_01720	COG3100	YcgL domain-containing protein
MF133_01725	COG2951	lytic endotransglycosylase activity
MF133_01730	COG1760	l-serine dehydratase
MF133_01735	COG1760	l-serine dehydratase
MF133_01740	COG3123	guanosine phosphorylase activity
MF133_01760	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MF133_01765	COG2067	long-chain fatty acid transport protein
MF133_01770	COG2067	long-chain fatty acid transport protein
MF133_01780	COG1595	DNA-templated transcription, initiation
MF133_01810	COG0714	Associated with various cellular activities
MF133_01815	COG0183	Belongs to the thiolase family
MF133_01820	COG1024	Enoyl-CoA hydratase
MF133_01820	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF133_01830	COG4681	YaeQ
MF133_01840	COG4383	Mu-like prophage protein gp29
MF133_01875	COG4695	Portal protein
MF133_01970	COG4974	Belongs to the 'phage' integrase family
MF133_01975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MF133_01980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF133_01980	COG0072	phenylalanine-tRNA ligase activity
MF133_01985	COG0776	regulation of translation
MF133_02020	COG1609	Transcriptional regulator
MF133_02025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF133_02030	COG1879	ABC-type sugar transport system periplasmic component
MF133_02035	COG1172	Belongs to the binding-protein-dependent transport system permease family
MF133_02040	COG1129	ABC transporter
MF133_02045	COG1869	D-ribose catabolic process
MF133_02050	COG0625	glutathione transferase activity
MF133_02065	COG0037	tRNA processing
MF133_02070	COG0589	response to stress
MF133_02075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MF133_02090	COG2217	Heavy metal translocating P-type atpase
MF133_02100	COG2010	Cytochrome c
MF133_02115	COG3278	Belongs to the heme-copper respiratory oxidase family
MF133_02125	COG1956	GAF domain-containing protein
MF133_02130	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MF133_02140	COG0308	aminopeptidase N
MF133_02150	COG2902	Dehydrogenase
MF133_02155	COG0167	dihydroorotate dehydrogenase activity
MF133_02165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MF133_02165	COG0116	Belongs to the methyltransferase superfamily
MF133_02175	COG0488	(ABC) transporter
MF133_02190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MF133_02195	COG1067	ATP-dependent peptidase activity
MF133_02320	COG3141	response to X-ray
MF133_02330	COG2995	paraquat-inducible protein a
MF133_02340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MF133_02340	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MF133_02350	COG2801	Transposase and inactivated derivatives
MF133_02375	COG0084	hydrolase, TatD family'
MF133_02380	COG0470	DNA polymerase III
MF133_02385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MF133_02390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MF133_02395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MF133_02400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MF133_02405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MF133_02410	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_02420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MF133_02425	COG0416	fatty acid biosynthetic process
MF133_02430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MF133_02435	COG1399	metal-binding, possibly nucleic acid-binding protein
MF133_02450	COG0564	pseudouridine synthase activity
MF133_02455	COG1530	ribonuclease E activity
MF133_02460	COG0306	phosphate transporter
MF133_02465	COG0717	Belongs to the dCTP deaminase family
MF133_02470	COG0572	uridine kinase
MF133_02475	COG0489	protein tyrosine kinase activity
MF133_02480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF133_02480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF133_02490	COG1254	Belongs to the acylphosphatase family
MF133_02495	COG0840	transmembrane signaling receptor activity
MF133_02500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MF133_02515	COG0709	Synthesizes selenophosphate from selenide and ATP
MF133_02520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MF133_02525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MF133_02530	COG3437	response regulator, receiver
MF133_02540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MF133_02550	COG1643	Atp-dependent helicase
MF133_02555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MF133_02555	COG0617	tRNA 3'-terminal CCA addition
MF133_02555	COG0517	IMP dehydrogenase activity
MF133_02560	COG2197	response regulator
MF133_02565	COG3314	Sporulation integral membrane protein YlbJ
MF133_02575	COG0583	DNA-binding transcription factor activity
MF133_02580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MF133_02590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MF133_02595	COG2832	Protein of unknown function (DUF454)
MF133_02600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MF133_02610	COG0697	spore germination
MF133_02625	COG0318	PFAM AMP-dependent synthetase and ligase
MF133_02630	COG0596	Alpha beta hydrolase
MF133_02640	COG1214	PFAM Peptidase M22, glycoprotease
MF133_02645	COG1199	ATP-dependent helicase activity
MF133_02655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MF133_02660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MF133_02665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MF133_02670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MF133_02670	COG0131	Imidazoleglycerol-phosphate dehydratase
MF133_02675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MF133_02680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MF133_02685	COG3437	response regulator, receiver
MF133_02690	COG2199	diguanylate cyclase activity
MF133_02695	COG2205	protein histidine kinase activity
MF133_02695	COG2198	Histidine kinase
MF133_02695	COG0784	Response regulator, receiver
MF133_02700	COG0107	imidazoleglycerol-phosphate synthase activity
MF133_02705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MF133_02705	COG0140	phosphoribosyl-ATP diphosphatase activity
MF133_02715	COG2378	regulation of single-species biofilm formation
MF133_02720	COG0318	PFAM AMP-dependent synthetase and ligase
MF133_02725	COG3134	Outer membrane lipoprotein
MF133_02740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF133_02755	COG2801	Transposase and inactivated derivatives
MF133_02775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MF133_02780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MF133_02785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MF133_02790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MF133_02820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MF133_02830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF133_02835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF133_02840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MF133_02845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MF133_02850	COG3313	Fe-S protein
MF133_02855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MF133_02855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MF133_02855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MF133_02860	COG1105	Belongs to the carbohydrate kinase PfkB family
MF133_02865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_02865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_02870	COG1609	Transcriptional regulator
MF133_02885	COG5654	RES domain protein
MF133_02890	COG0513	Belongs to the DEAD box helicase family
MF133_02900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MF133_02905	COG2890	protein-(glutamine-N5) methyltransferase activity
MF133_02910	COG2840	Smr protein MutS2
MF133_02945	COG2824	Alkylphosphonate utilization operon protein PhnA
MF133_02950	COG1280	lysine exporter protein (LysE YggA)
MF133_02985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MF133_03010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MF133_03015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MF133_03020	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MF133_03030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MF133_03035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MF133_03045	COG0205	6-phosphofructokinase activity
MF133_03050	COG1473	amidohydrolase
MF133_03055	COG1011	Hydrolase
MF133_03060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MF133_03105	COG3593	DNA synthesis involved in DNA repair
MF133_03120	COG0583	DNA-binding transcription factor activity
MF133_03125	COG0730	response to heat
MF133_03150	COG3148	PFAM DTW domain containing protein
MF133_03155	COG1181	Belongs to the D-alanine--D-alanine ligase family
MF133_03165	COG0386	Belongs to the glutathione peroxidase family
MF133_03170	COG0513	Belongs to the DEAD box helicase family
MF133_03185	COG1742	UPF0060 membrane protein
MF133_03210	COG2329	Antibiotic biosynthesis monooxygenase
MF133_03215	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MF133_03235	COG3243	poly(R)-hydroxyalkanoic acid synthase
MF133_03245	COG2501	S4 domain
MF133_03265	COG1132	(ABC) transporter
MF133_03270	COG1132	(ABC) transporter
MF133_03280	COG3118	belongs to the thioredoxin family
MF133_03285	COG0471	metal ion transport
MF133_03295	COG0058	SHG alpha-glucan phosphorylase activity
MF133_03325	COG0814	amino acid
MF133_03330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MF133_03335	COG0514	ATP-dependent DNA helicase (RecQ)
MF133_03340	COG2766	serine protein kinase
MF133_03345	COG2718	Belongs to the UPF0229 family
MF133_03350	COG2719	SpoVR family
MF133_03355	COG2186	Transcriptional regulator
MF133_03360	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF133_03365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MF133_03370	COG0586	Pfam SNARE associated Golgi protein
MF133_03380	COG0556	nucleotide-excision repair
MF133_03390	COG0569	domain protein
MF133_03390	COG2985	domain, Protein
MF133_03395	COG0739	heme binding
MF133_03395	COG0741	lytic transglycosylase activity
MF133_03395	COG1196	nuclear chromosome segregation
MF133_03400	COG3181	Tripartite tricarboxylate transporter family receptor
MF133_03415	COG4565	transcriptional regulatory protein
MF133_03420	COG3290	protein histidine kinase activity
MF133_03425	COG1846	Transcriptional regulator
MF133_03425	COG1940	carbohydrate kinase activity
MF133_03430	COG0840	transmembrane signaling receptor activity
MF133_03435	COG3012	SEC-C Motif Domain Protein
MF133_03440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MF133_03445	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
MF133_03450	COG0247	lactate metabolic process
MF133_03470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MF133_03475	COG0437	4 iron, 4 sulfur cluster binding
MF133_03480	COG3301	Polysulphide reductase, NrfD
MF133_03485	COG1138	Cytochrome C-type biogenesis protein
MF133_03490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF133_03495	COG3088	subunit of a heme lyase
MF133_03495	COG4235	cytochrome complex assembly
MF133_03510	COG3046	protein related to deoxyribodipyrimidine photolyase
MF133_03515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF133_03530	COG0517	IMP dehydrogenase activity
MF133_03530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MF133_03530	COG0617	tRNA 3'-terminal CCA addition
MF133_03540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MF133_03555	COG4774	siderophore transport
MF133_03565	COG3706	GGDEF domain
MF133_03570	COG2200	EAL domain
MF133_03575	COG1917	Cupin 2, conserved barrel domain protein
MF133_03575	COG4977	sequence-specific DNA binding
MF133_03580	COG0583	DNA-binding transcription factor activity
MF133_03585	COG2910	NAD(P)H-binding
MF133_03595	COG0626	cystathionine gamma-synthase activity
MF133_03600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MF133_03635	COG2723	6-phospho-beta-galactosidase activity
MF133_03640	COG1263	PTS System
MF133_03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_03640	COG2190	(PTS) system
MF133_03645	COG1737	Transcriptional regulator
MF133_03670	COG1435	thymidine kinase activity
MF133_03675	COG1757	Na H antiporter
MF133_03680	COG2916	Histone family protein nucleoid-structuring protein H-NS
MF133_03685	COG2096	Adenosyltransferase
MF133_03690	COG3530	Putative quorum-sensing-regulated virulence factor
MF133_03695	COG0602	queuosine metabolic process
MF133_03700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MF133_03720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MF133_03730	COG0776	regulation of translation
MF133_03735	COG0539	negative regulation of cytoplasmic translation
MF133_03740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MF133_03745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MF133_03775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MF133_03780	COG3300	MHYT domain
MF133_03780	COG5001	Diguanylate cyclase
MF133_03795	COG0745	RESPONSE REGULATOR receiver
MF133_03820	COG4989	oxidoreductase activity
MF133_03825	COG0724	RNA recognition motif
MF133_03845	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MF133_03860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MF133_03865	COG1360	Flagellar Motor Protein
MF133_03870	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF133_03875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF133_03880	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF133_03880	COG0649	NAD binding
MF133_03895	COG1034	ATP synthesis coupled electron transport
MF133_03900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MF133_03905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF133_03910	COG0839	Belongs to the complex I subunit 6 family
MF133_03915	COG0713	ATP synthesis coupled electron transport
MF133_03925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF133_03930	COG1007	ATP synthesis coupled electron transport
MF133_03935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MF133_03935	COG0047	phosphoribosylformylglycinamidine synthase activity
MF133_03940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MF133_03945	COG1645	bacterial-type flagellum-dependent swarming motility
MF133_03950	COG1160	GTP binding
MF133_03955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF133_03960	COG2976	Protein conserved in bacteria
MF133_03965	COG0124	histidyl-tRNA synthetase
MF133_03975	COG1426	Protein conserved in bacteria
MF133_03985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MF133_03990	COG0105	UTP biosynthetic process
MF133_03995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MF133_04005	COG0633	Ferredoxin
MF133_04010	COG0443	Heat shock 70 kDa protein
MF133_04015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MF133_04025	COG0822	iron-sulfur transferase activity
MF133_04030	COG1104	cysteine desulfurase activity
MF133_04045	COG3154	lipid carrier protein
MF133_04050	COG0826	peptidase U32
MF133_04055	COG0826	peptidase U32
MF133_04065	COG2897	thiosulfate sulfurtransferase activity
MF133_04070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF133_04075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF133_04080	COG1862	Preprotein translocase
MF133_04085	COG0343	queuine tRNA-ribosyltransferase activity
MF133_04090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MF133_04095	COG0517	IMP dehydrogenase activity
MF133_04100	COG0450	alkyl hydroperoxide reductase
MF133_04105	COG3634	alkyl hydroperoxide reductase activity
MF133_04110	COG0477	Major facilitator Superfamily
MF133_04130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MF133_04130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MF133_04135	COG0509	glycine decarboxylation via glycine cleavage system
MF133_04140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MF133_04145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF133_04150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF133_04170	COG2814	Major facilitator Superfamily
MF133_04175	COG0444	Belongs to the ABC transporter superfamily
MF133_04180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF133_04185	COG0601	transmembrane transport
MF133_04195	COG0625	glutathione transferase activity
MF133_04200	COG0625	glutathione transferase activity
MF133_04210	COG0483	inositol monophosphate 1-phosphatase activity
MF133_04225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MF133_04230	COG2056	Na+-H+ antiporter family
MF133_04235	COG2814	Major facilitator Superfamily
MF133_04240	COG0583	DNA-binding transcription factor activity
MF133_04245	COG5001	Diguanylate cyclase
MF133_04260	COG2050	protein possibly involved in aromatic compounds catabolism
MF133_04270	COG0247	lactate metabolic process
MF133_04270	COG0277	FAD linked oxidase domain protein
MF133_04285	COG1253	flavin adenine dinucleotide binding
MF133_04290	COG1902	pentaerythritol trinitrate reductase activity
MF133_04295	COG0604	alcohol dehydrogenase
MF133_04300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MF133_04305	COG0647	UMP catabolic process
MF133_04310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MF133_04310	COG4651	solute:proton antiporter activity
MF133_04320	COG0367	asparagine synthase
MF133_04335	COG0625	glutathione transferase activity
MF133_04345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MF133_04360	COG0564	pseudouridine synthase activity
MF133_04365	COG5001	Diguanylate cyclase
MF133_04370	COG0840	transmembrane signaling receptor activity
MF133_04375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MF133_04410	COG0670	Belongs to the BI1 family
MF133_04415	COG1289	transmembrane transporter activity
MF133_04420	COG2920	part of a sulfur-relay system
MF133_04425	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MF133_04430	COG0285	dihydrofolate synthase activity
MF133_04435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MF133_04440	COG0101	tRNA pseudouridine synthase activity
MF133_04450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MF133_04455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MF133_04465	COG1464	Belongs to the NlpA lipoprotein family
MF133_04490	COG1119	ATPase activity
MF133_04495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MF133_04495	COG0574	Belongs to the PEP-utilizing enzyme family
MF133_04500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MF133_04510	COG1113	amino acid transport
MF133_04610	COG1242	4 iron, 4 sulfur cluster binding
MF133_04615	COG0069	glutamate synthase activity
MF133_04615	COG0067	glutamate synthase
MF133_04615	COG0070	glutamate synthase
MF133_04620	COG0493	'glutamate synthase
MF133_04625	COG1126	abc transporter atp-binding protein
MF133_04630	COG0765	amino acid transport
MF133_04635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_04660	COG4104	PAAR repeat-containing protein
MF133_04670	COG0513	Belongs to the DEAD box helicase family
MF133_04695	COG3706	GGDEF domain
MF133_04700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MF133_04705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MF133_04710	COG0505	Belongs to the CarA family
MF133_04715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MF133_04725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MF133_04730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MF133_04735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MF133_04740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MF133_04745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF133_04750	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MF133_04755	COG4139	cobalamin transport
MF133_04780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MF133_04790	COG0023	Translation Initiation Factor
MF133_04795	COG2119	membrane
MF133_04830	COG2199	diguanylate cyclase activity
MF133_04830	COG2203	Gaf domain
MF133_04850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MF133_04860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF133_04865	COG2261	transglycosylase associated protein
MF133_04870	COG1309	transcriptional regulator
MF133_04875	COG0604	alcohol dehydrogenase
MF133_04940	COG0322	excinuclease ABC activity
MF133_04945	COG2197	response regulator
MF133_04950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MF133_04955	COG2835	tetraacyldisaccharide 4'-kinase activity
MF133_04960	COG1663	tetraacyldisaccharide 4'-kinase activity
MF133_04965	COG1132	(ABC) transporter
MF133_04970	COG0658	competence protein
MF133_04970	COG2333	competence protein COMEC
MF133_04985	COG0433	COG0433 Predicted ATPase
MF133_04990	COG1448	Aminotransferase
MF133_05005	COG1199	ATP-dependent helicase activity
MF133_05015	COG0123	including yeast histone deacetylase and acetoin utilization protein
MF133_05020	COG0477	Major facilitator Superfamily
MF133_05025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MF133_05030	COG1785	Belongs to the alkaline phosphatase family
MF133_05050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MF133_05055	COG3706	GGDEF domain
MF133_05060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_05065	COG0765	amino acid transport
MF133_05070	COG1126	abc transporter atp-binding protein
MF133_05080	COG0531	amino acid
MF133_05095	COG1253	flavin adenine dinucleotide binding
MF133_05100	COG0704	Plays a role in the regulation of phosphate uptake
MF133_05105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MF133_05110	COG0581	inorganic phosphate transmembrane transporter activity
MF133_05115	COG0573	inorganic phosphate transmembrane transporter activity
MF133_05120	COG0590	tRNA wobble adenosine to inosine editing
MF133_05135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MF133_05155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MF133_05160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MF133_05165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MF133_05170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MF133_05195	COG2716	regulation of RNA biosynthetic process
MF133_05200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MF133_05210	COG2239	Acts as a magnesium transporter
MF133_05225	COG1705	Flagellar rod assembly protein muramidase FlgJ
MF133_05225	COG3951	Flagellar rod assembly protein muramidase FlgJ
MF133_05230	COG1706	bacterial-type flagellum-dependent cell motility
MF133_05235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MF133_05250	COG1749	Flagellar hook protein flgE
MF133_05265	COG1815	bacterial-type flagellum-dependent cell motility
MF133_05270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MF133_05275	COG0784	Response regulator, receiver
MF133_05275	COG0835	chemotaxis
MF133_05280	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MF133_05295	COG0622	Phosphoesterase
MF133_05300	COG4166	transmembrane transport
MF133_05315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MF133_05325	COG0697	spore germination
MF133_05330	COG4166	transmembrane transport
MF133_05355	COG1278	Cold shock
MF133_05395	COG3132	Protein of unknown function, DUF480
MF133_05405	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
MF133_05425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MF133_05435	COG1215	transferase activity, transferring glycosyl groups
MF133_05455	COG2244	polysaccharide biosynthetic process
MF133_05465	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_05470	COG1083	cytidylyl-transferase
MF133_05475	COG0673	inositol 2-dehydrogenase activity
MF133_05490	COG2089	acid synthase
MF133_05500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MF133_05510	COG2030	dehydratase
MF133_05515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MF133_05545	COG1737	Transcriptional regulator
MF133_05550	COG0469	pyruvate kinase activity
MF133_05560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF133_05565	COG1960	acyl-CoA dehydrogenase activity
MF133_05575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MF133_05595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF133_05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_05605	COG1309	transcriptional regulator
MF133_05620	COG1946	Acyl-CoA thioesterase
MF133_05630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MF133_05640	COG0009	L-threonylcarbamoyladenylate synthase
MF133_05645	COG0613	PHP domain protein
MF133_05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MF133_05655	COG0512	Glutamine amidotransferase of anthranilate synthase
MF133_05655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MF133_05660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MF133_05665	COG0135	phosphoribosylanthranilate isomerase activity
MF133_05665	COG0134	indole-3-glycerol-phosphate synthase activity
MF133_05670	COG0133	tryptophan synthase activity
MF133_05675	COG0159	tryptophan synthase activity
MF133_05705	COG0583	DNA-binding transcription factor activity
MF133_05715	COG4521	taurine ABC transporter
MF133_05720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MF133_05725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF133_05730	COG2175	clavaminate synthase activity
MF133_05735	COG5507	3-demethylubiquinone-9 3-methyltransferase
MF133_05740	COG2814	Major facilitator Superfamily
MF133_05745	COG0109	protoheme IX farnesyltransferase activity
MF133_05750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MF133_05755	COG1845	cytochrome c oxidase, subunit III
MF133_05760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MF133_05765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MF133_05770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MF133_05775	COG0583	DNA-binding transcription factor activity
MF133_05795	COG1846	Transcriptional regulator
MF133_05810	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MF133_05825	COG0745	RESPONSE REGULATOR receiver
MF133_05835	COG0708	Exodeoxyribonuclease III
MF133_05845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_05850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF133_05865	COG0095	Lipoate-protein ligase
MF133_05895	COG0640	Transcriptional regulator
MF133_05905	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF133_05915	COG1285	pathogenesis
MF133_05945	COG0484	heat shock protein binding
MF133_05950	COG0443	Heat shock 70 kDa protein
MF133_05955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MF133_05960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MF133_05965	COG3706	GGDEF domain
MF133_05970	COG0497	DNA recombination
MF133_05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_05985	COG0577	efflux transmembrane transporter activity
MF133_05985	COG1136	(ABC) transporter
MF133_05990	COG1538	Outer membrane efflux protein
MF133_05995	COG2375	cellular response to nickel ion
MF133_06000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF133_06005	COG2916	Histone family protein nucleoid-structuring protein H-NS
MF133_06010	COG0583	DNA-binding transcription factor activity
MF133_06015	COG3048	D-serine ammonia-lyase activity
MF133_06025	COG0538	isocitrate dehydrogenase activity
MF133_06065	COG0456	acetyltransferase
MF133_06070	COG1187	pseudouridine synthase activity
MF133_06080	COG0482	sulfurtransferase activity
MF133_06085	COG2915	High frequency lysogenization protein hflD homolog
MF133_06090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MF133_06095	COG2850	peptidyl-arginine hydroxylation
MF133_06105	COG1196	nuclear chromosome segregation
MF133_06105	COG3264	Mechanosensitive ion channel
MF133_06115	COG2706	6-phosphogluconolactonase activity
MF133_06135	COG0281	malic enzyme
MF133_06140	COG0746	molybdenum cofactor guanylyltransferase activity
MF133_06145	COG1763	Mo-molybdopterin cofactor biosynthetic process
MF133_06150	COG1289	transmembrane transporter activity
MF133_06155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MF133_06185	COG3220	belongs to the UPF0276 family
MF133_06195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MF133_06225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MF133_06230	COG0083	homoserine kinase activity
MF133_06240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MF133_06245	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MF133_06260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MF133_06270	COG0745	RESPONSE REGULATOR receiver
MF133_06285	COG4988	ABC transporter
MF133_06290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MF133_06310	COG1720	tRNA m6t6A37 methyltransferase activity
MF133_06325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MF133_06330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MF133_06335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_06345	COG2190	(PTS) system
MF133_06350	COG3038	cytochrome b561
MF133_06360	COG0420	3'-5' exonuclease activity
MF133_06370	COG2974	May be involved in recombination
MF133_06380	COG0405	Gamma-glutamyltransferase
MF133_06385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MF133_06385	COG4651	solute:proton antiporter activity
MF133_06420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF133_06425	COG1396	sequence-specific DNA binding
MF133_06425	COG1917	Cupin 2, conserved barrel domain protein
MF133_06430	COG1012	belongs to the aldehyde dehydrogenase family
MF133_06445	COG0531	amino acid
MF133_06450	COG0531	amino acid
MF133_06460	COG1283	sodium-dependent phosphate transmembrane transporter activity
MF133_06470	COG3384	dioxygenase
MF133_06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_06475	COG2205	protein histidine kinase activity
MF133_06500	COG0784	Response regulator, receiver
MF133_06500	COG2205	protein histidine kinase activity
MF133_06510	COG1388	LysM domain
MF133_06510	COG1376	ErfK ybiS ycfS ynhG family protein
MF133_06525	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MF133_06530	COG0791	NLP P60 protein
MF133_06540	COG3118	belongs to the thioredoxin family
MF133_06550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MF133_06555	COG0788	formyltetrahydrofolate deformylase activity
MF133_06580	COG0741	lytic transglycosylase activity
MF133_06580	COG1196	nuclear chromosome segregation
MF133_06580	COG0739	heme binding
MF133_06585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MF133_06590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MF133_06595	COG0673	inositol 2-dehydrogenase activity
MF133_06625	COG0604	alcohol dehydrogenase
MF133_06640	COG0583	DNA-binding transcription factor activity
MF133_06645	COG1032	radical SAM domain protein
MF133_06650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF133_06660	COG3706	GGDEF domain
MF133_06665	COG1752	Esterase of the alpha-beta hydrolase superfamily
MF133_06670	COG0733	neurotransmitter:sodium symporter activity
MF133_06700	COG0281	malic enzyme
MF133_06705	COG2207	Transcriptional regulator
MF133_06725	COG2233	PERMEase
MF133_06730	COG0095	Lipoate-protein ligase
MF133_06735	COG1115	amino acid carrier protein
MF133_06740	COG0019	diaminopimelate decarboxylase activity
MF133_06750	COG0678	peroxiredoxin activity
MF133_06755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MF133_06765	COG1126	abc transporter atp-binding protein
MF133_06770	COG0765	amino acid transport
MF133_06775	COG4597	amino acid ABC transporter
MF133_06780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_06800	COG0545	Peptidyl-prolyl cis-trans isomerase
MF133_06835	COG1940	carbohydrate kinase activity
MF133_06845	COG4783	chaperone-mediated protein folding
MF133_06865	COG0745	RESPONSE REGULATOR receiver
MF133_06870	COG0346	lactoylglutathione lyase activity
MF133_06875	COG3706	GGDEF domain
MF133_06880	COG3284	Transcriptional regulator
MF133_06895	COG0697	spore germination
MF133_06905	COG0667	Aldo Keto reductase
MF133_06920	COG3290	protein histidine kinase activity
MF133_06930	COG1566	PFAM secretion protein HlyD family protein
MF133_06960	COG1328	CTP reductase activity
MF133_06970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MF133_06975	COG3115	cell septum assembly
MF133_06980	COG1196	nuclear chromosome segregation
MF133_06990	COG2860	membrane
MF133_07000	COG3108	Peptidase M15
MF133_07005	COG2989	Protein conserved in bacteria
MF133_07020	COG0463	Glycosyl transferase, family 2
MF133_07035	COG0366	Alpha amylase catalytic
MF133_07070	COG3706	GGDEF domain
MF133_07075	COG0037	tRNA processing
MF133_07090	COG0488	(ABC) transporter
MF133_07100	COG0531	amino acid
MF133_07105	COG0814	amino acid
MF133_07120	COG0825	malonyl-CoA metabolic process
MF133_07130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MF133_07135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF133_07140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF133_07145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MF133_07150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF133_07165	COG0750	zinc metalloprotease
MF133_07170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MF133_07175	COG0575	Belongs to the CDS family
MF133_07180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MF133_07185	COG0233	cytoplasmic translational termination
MF133_07190	COG0528	UMP kinase activity
MF133_07195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MF133_07200	COG0052	Belongs to the universal ribosomal protein uS2 family
MF133_07205	COG0024	Methionine aminopeptidase
MF133_07210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MF133_07215	COG2171	N-acyltransferase activity
MF133_07225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_07225	COG1263	PTS System
MF133_07235	COG4580	involved in the transport of maltose and maltodextrins
MF133_07250	COG0564	pseudouridine synthase activity
MF133_07255	COG3098	single-species biofilm formation
MF133_07280	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MF133_07290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MF133_07290	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MF133_07305	COG1611	Belongs to the LOG family
MF133_07310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MF133_07315	COG0473	3-isopropylmalate dehydrogenase activity
MF133_07325	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MF133_07340	COG0583	DNA-binding transcription factor activity
MF133_07345	COG0840	transmembrane signaling receptor activity
MF133_07350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MF133_07365	COG1477	protein flavinylation
MF133_07370	COG2871	sodium ion transport
MF133_07375	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MF133_07380	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MF133_07385	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MF133_07390	COG1805	sodium ion transport
MF133_07395	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MF133_07400	COG0271	Belongs to the BolA IbaG family
MF133_07405	COG2813	Specifically methylates the guanine in position
MF133_07415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MF133_07425	COG2211	Major facilitator Superfamily
MF133_07435	COG1666	GTP binding
MF133_07440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MF133_07480	COG4104	PAAR repeat-containing protein
MF133_07500	COG2771	luxR family
MF133_07505	COG0659	secondary active sulfate transmembrane transporter activity
MF133_07510	COG5002	protein histidine kinase activity
MF133_07510	COG5000	phosphorelay sensor kinase activity
MF133_07520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_07545	COG1609	Transcriptional regulator
MF133_07550	COG2182	Extracellular solute-binding protein
MF133_07560	COG1472	Belongs to the glycosyl hydrolase 3 family
MF133_07565	COG5297	Belongs to the glycosyl hydrolase family 6
MF133_07565	COG2273	Hydrolase Family 16
MF133_07570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF133_07580	COG2723	6-phospho-beta-galactosidase activity
MF133_07585	COG1447	Phosphotransferase system cellobiose-specific component IIA
MF133_07605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MF133_07615	COG1151	hydroxylamine reductase activity
MF133_07620	COG0783	Belongs to the Dps family
MF133_07645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MF133_07660	COG4221	oxidoreductase activity
MF133_07670	COG0415	Belongs to the DNA photolyase family
MF133_07675	COG0789	Transcriptional regulator
MF133_07680	COG3272	Protein of unknown function (DUF1722)
MF133_07705	COG0077	Prephenate dehydratase
MF133_07705	COG1605	Chorismate mutase
MF133_07730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_07750	COG0457	Tetratricopeptide repeat
MF133_07770	COG1349	DNA-binding transcription factor activity
MF133_07775	COG2084	Dehydrogenase
MF133_07785	COG0235	Class ii aldolase
MF133_07790	COG3622	Belongs to the hyi family
MF133_07795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MF133_07800	COG2610	gluconate transmembrane transporter activity
MF133_07810	COG0840	transmembrane signaling receptor activity
MF133_07825	COG0300	oxidoreductase activity
MF133_07850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MF133_07860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MF133_07870	COG3813	Protein conserved in bacteria
MF133_07880	COG0826	peptidase U32
MF133_07885	COG1280	lysine exporter protein (LysE YggA)
MF133_07895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MF133_07920	COG2199	diguanylate cyclase activity
MF133_07920	COG2200	EAL domain
MF133_07920	COG2203	Gaf domain
MF133_07965	COG1566	PFAM secretion protein HlyD family protein
MF133_07975	COG0114	fumarate hydratase activity
MF133_07985	COG0506	proline dehydrogenase activity
MF133_07985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MF133_07985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MF133_07990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MF133_08005	COG0737	Belongs to the 5'-nucleotidase family
MF133_08040	COG2900	Belongs to the SlyX family
MF133_08045	COG1047	Peptidyl-prolyl cis-trans
MF133_08050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MF133_08060	COG0784	Response regulator, receiver
MF133_08060	COG0835	chemotaxis
MF133_08065	COG0429	hydrolase of the alpha beta-hydrolase fold
MF133_08070	COG2203	Gaf domain
MF133_08070	COG3706	GGDEF domain
MF133_08070	COG4251	negative regulation of phosphorylation
MF133_08070	COG5001	Diguanylate cyclase
MF133_08075	COG3089	Belongs to the UPF0270 family
MF133_08080	COG3954	Phosphoribulokinase
MF133_08095	COG1765	OsmC-like protein
MF133_08105	COG2226	methyltransferase
MF133_08115	COG2205	protein histidine kinase activity
MF133_08120	COG2814	Major facilitator Superfamily
MF133_08145	COG0748	coenzyme F420 binding
MF133_08150	COG3721	Heme iron utilization protein
MF133_08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF133_08185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MF133_08200	COG0741	lytic transglycosylase activity
MF133_08205	COG0488	(ABC) transporter
MF133_08215	COG2252	PERMEase
MF133_08220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MF133_08225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MF133_08230	COG3178	'Phosphotransferase
MF133_08235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MF133_08245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MF133_08250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MF133_08255	COG2967	ApaG domain
MF133_08260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MF133_08270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MF133_08275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MF133_08280	COG3314	Sporulation integral membrane protein YlbJ
MF133_08285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MF133_08290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MF133_08295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MF133_08300	COG0142	geranyltranstransferase activity
MF133_08305	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MF133_08310	COG0330	HflC and HflK could
MF133_08315	COG0330	HflC and HflK could
MF133_08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MF133_08325	COG1923	regulation of RNA biosynthetic process
MF133_08330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MF133_08335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MF133_08345	COG0802	atpase or kinase
MF133_08350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MF133_08350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MF133_08370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MF133_08375	COG2011	ABC-type metal ion transport system permease component
MF133_08380	COG1464	Belongs to the NlpA lipoprotein family
MF133_08400	COG0784	Response regulator, receiver
MF133_08400	COG2205	protein histidine kinase activity
MF133_08415	COG5002	protein histidine kinase activity
MF133_08415	COG0784	Response regulator, receiver
MF133_08415	COG2198	Histidine kinase
MF133_08435	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MF133_08450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MF133_08455	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MF133_08460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF133_08465	COG2716	regulation of RNA biosynthetic process
MF133_08470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MF133_08475	COG3013	Belongs to the UPF0304 family
MF133_08485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MF133_08490	COG0857	belongs to the CobB CobQ family
MF133_08490	COG0280	phosphate acetyltransferase
MF133_08495	COG0440	acetolactate synthase activity
MF133_08500	COG0028	Belongs to the TPP enzyme family
MF133_08525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MF133_08530	COG0473	3-isopropylmalate dehydrogenase activity
MF133_08535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MF133_08540	COG0066	3-isopropylmalate dehydratase activity
MF133_08555	COG4143	(ABC) transporter
MF133_08560	COG1178	ABC-type Fe3 transport system permease component
MF133_08565	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MF133_08575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MF133_08585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF133_08615	COG0316	Belongs to the HesB IscA family
MF133_08625	COG0038	chloride channel
MF133_08630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MF133_08645	COG0671	phosphoesterase, PA-phosphatase related
MF133_08655	COG0583	DNA-binding transcription factor activity
MF133_08660	COG2076	Multidrug Resistance protein
MF133_08670	COG0346	lactoylglutathione lyase activity
MF133_08675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF133_08680	COG1643	Atp-dependent helicase
MF133_08690	COG1489	DNA binding
MF133_08695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MF133_08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF133_08710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MF133_08720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MF133_08730	COG0842	Transport permease protein
MF133_08735	COG1131	(ABC) transporter
MF133_08750	COG0163	prenyltransferase activity
MF133_08755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MF133_08760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MF133_08775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MF133_08790	COG1136	(ABC) transporter
MF133_08825	COG0529	Catalyzes the synthesis of activated sulfate
MF133_08830	COG3273	potassium ion transport
MF133_08830	COG0471	metal ion transport
MF133_08835	COG2895	sulfate adenylyltransferase (ATP) activity
MF133_08840	COG0175	sulfate reduction
MF133_08845	COG1648	precorrin-2 dehydrogenase activity
MF133_08845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MF133_08850	COG0330	HflC and HflK could
MF133_08855	COG1585	Membrane protein implicated in regulation of membrane protease activity
MF133_08865	COG0673	inositol 2-dehydrogenase activity
MF133_08875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MF133_08880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MF133_08885	COG3036	rescue of stalled ribosome
MF133_08900	COG0138	bifunctional purine biosynthesis protein purh
MF133_08905	COG0151	Belongs to the GarS family
MF133_08980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MF133_08985	COG0358	DNA primase activity
MF133_08990	COG1610	YqeY-like protein
MF133_08995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MF133_09000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MF133_09010	COG1388	LysM domain
MF133_09010	COG4942	peptidase
MF133_09015	COG1238	metal cluster binding
MF133_09020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MF133_09025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MF133_09030	COG0585	pseudouridine synthase activity
MF133_09040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MF133_09045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MF133_09050	COG0148	phosphopyruvate hydratase activity
MF133_09055	COG0504	CTP synthase activity
MF133_09060	COG3956	TIGRFAM MazG family protein
MF133_09065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MF133_09070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MF133_09080	COG4807	Protein conserved in bacteria
MF133_09085	COG3023	N-Acetylmuramoyl-L-alanine amidase
MF133_09090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MF133_09095	COG1381	Involved in DNA repair and RecF pathway recombination
MF133_09105	COG0571	ribonuclease III activity
MF133_09110	COG0681	Belongs to the peptidase S26 family
MF133_09115	COG0481	GTPase activity
MF133_09135	COG1595	DNA-templated transcription, initiation
MF133_09140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MF133_09150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MF133_09155	COG0354	folic acid binding
MF133_09160	COG0583	DNA-binding transcription factor activity
MF133_09190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF133_09200	COG0126	phosphoglycerate kinase activity
MF133_09205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MF133_09210	COG1940	carbohydrate kinase activity
MF133_09215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MF133_09225	COG4991	sh3 domain protein
MF133_09230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MF133_09245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MF133_09250	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_09260	COG1505	serine-type exopeptidase activity
MF133_09265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MF133_09270	COG0765	amino acid transport
MF133_09275	COG0765	amino acid transport
MF133_09280	COG1126	abc transporter atp-binding protein
MF133_09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_09290	COG3174	membrane
MF133_09295	COG0110	maltose O-acetyltransferase activity
MF133_09325	COG1942	4-Oxalocrotonate Tautomerase
MF133_09335	COG0583	DNA-binding transcription factor activity
MF133_09340	COG0165	Argininosuccinate lyase
MF133_09345	COG0137	argininosuccinate synthase activity
MF133_09355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MF133_09360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MF133_09370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MF133_09380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MF133_09415	COG0583	DNA-binding transcription factor activity
MF133_09420	COG1380	Effector of murein hydrolase LrgA
MF133_09425	COG1346	cytolysis
MF133_09430	COG0527	aspartate kinase activity
MF133_09430	COG0460	homoserine dehydrogenase
MF133_09435	COG0626	cystathionine gamma-synthase activity
MF133_09450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF133_09455	COG0814	amino acid
MF133_09460	COG1218	3'(2'),5'-bisphosphate nucleotidase
MF133_09465	COG0494	nUDIX hydrolase
MF133_09470	COG1011	Hydrolase
MF133_09475	COG1902	pentaerythritol trinitrate reductase activity
MF133_09485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MF133_09500	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MF133_09510	COG3156	type II secretion system protein K
MF133_09520	COG4795	General secretion pathway protein
MF133_09525	COG2165	general secretion pathway protein
MF133_09535	COG2165	general secretion pathway protein
MF133_09540	COG1459	type II secretion system
MF133_09545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MF133_09555	COG3031	protein transport across the cell outer membrane
MF133_09565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MF133_09570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MF133_09585	COG0456	acetyltransferase
MF133_09590	COG3133	Outer membrane lipoprotein
MF133_09595	COG3025	triphosphatase activity
MF133_09600	COG1392	Phosphate transport regulator
MF133_09605	COG0306	phosphate transporter
MF133_09610	COG0617	tRNA 3'-terminal CCA addition
MF133_09615	COG3409	Peptidoglycan-binding domain 1 protein
MF133_09615	COG3267	Type II secretory pathway component ExeA
MF133_09625	COG1194	a g-specific adenine glycosylase
MF133_09630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MF133_09645	COG3240	lipase activity
MF133_09655	COG3009	Protein conserved in bacteria
MF133_09660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MF133_09660	COG3008	intermembrane lipid transfer
MF133_09665	COG2995	paraquat-inducible protein a
MF133_09675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF133_09680	COG4251	negative regulation of phosphorylation
MF133_09680	COG3706	GGDEF domain
MF133_09680	COG2203	Gaf domain
MF133_09680	COG5001	Diguanylate cyclase
MF133_09685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF133_09690	COG2813	Specifically methylates the guanine in position
MF133_09695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MF133_09700	COG0297	glycogen (starch) synthase activity
MF133_09740	COG1757	Na H antiporter
MF133_09745	COG0583	DNA-binding transcription factor activity
MF133_09750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MF133_09755	COG3842	ATPase activity
MF133_09760	COG1176	ABC-type spermidine putrescine transport system, permease component I
MF133_09765	COG1177	transmembrane transport
MF133_09770	COG1012	belongs to the aldehyde dehydrogenase family
MF133_09775	COG0109	protoheme IX farnesyltransferase activity
MF133_09805	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MF133_09815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MF133_09815	COG1565	acr, cog1565
MF133_09820	COG1444	tRNA N-acetyltransferase activity
MF133_09840	COG1803	Methylglyoxal synthase
MF133_09855	COG0252	asparaginase activity
MF133_09865	COG1609	Transcriptional regulator
MF133_09875	COG1940	carbohydrate kinase activity
MF133_09880	COG1447	Phosphotransferase system cellobiose-specific component IIA
MF133_09885	COG2723	6-phospho-beta-galactosidase activity
MF133_09890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF133_09890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF133_09895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF133_09900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF133_09920	COG1263	PTS System
MF133_09920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_09925	COG0366	Alpha amylase catalytic
MF133_09930	COG0110	maltose O-acetyltransferase activity
MF133_09935	COG1522	sequence-specific DNA binding
MF133_09985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MF133_09990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MF133_10005	COG0477	Major facilitator Superfamily
MF133_10010	COG0523	cobalamin synthesis protein
MF133_10030	COG2200	EAL domain
MF133_10035	COG1049	propionate catabolic process, 2-methylcitrate cycle
MF133_10040	COG1752	Esterase of the alpha-beta hydrolase superfamily
MF133_10045	COG0840	transmembrane signaling receptor activity
MF133_10050	COG0840	transmembrane signaling receptor activity
MF133_10060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF133_10065	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF133_10070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MF133_10075	COG2186	Transcriptional regulator
MF133_10100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MF133_10105	COG1459	type II secretion system
MF133_10110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MF133_10120	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MF133_10125	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MF133_10130	COG0494	nUDIX hydrolase
MF133_10140	COG0653	protein targeting
MF133_10150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MF133_10155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MF133_10160	COG0849	cell division
MF133_10165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MF133_10170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MF133_10175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MF133_10180	COG0772	Belongs to the SEDS family
MF133_10185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MF133_10190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MF133_10195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MF133_10200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MF133_10205	COG0768	penicillin binding
MF133_10210	COG3116	cell division
MF133_10215	COG0275	rRNA processing
MF133_10220	COG2001	Belongs to the MraZ family
MF133_10230	COG0741	lytic transglycosylase activity
MF133_10230	COG1388	LysM domain
MF133_10240	COG1360	Flagellar Motor Protein
MF133_10245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MF133_10250	COG1191	sigma factor activity
MF133_10275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MF133_10280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF133_10285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF133_10300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF133_10305	COG1256	bacterial-type flagellum assembly
MF133_10305	COG4786	Flagellar basal body rod
MF133_10315	COG1706	bacterial-type flagellum-dependent cell motility
MF133_10320	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MF133_10325	COG4786	Flagellar basal body rod
MF133_10335	COG1749	Flagellar hook protein flgE
MF133_10350	COG1815	bacterial-type flagellum-dependent cell motility
MF133_10355	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MF133_10385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MF133_10395	COG1677	Flagellar hook-basal body complex protein FliE
MF133_10420	COG1987	bacterial-type flagellum assembly
MF133_10445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MF133_10450	COG3107	peptidoglycan biosynthetic process
MF133_10455	COG0792	nuclease activity
MF133_10460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MF133_10465	COG2823	Periplasmic or secreted lipoprotein
MF133_10470	COG2969	positive regulation of protein catabolic process
MF133_10475	COG0625	glutathione transferase activity
MF133_10480	COG2857	Cytochrome c1
MF133_10485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MF133_10490	COG0723	plastoquinol--plastocyanin reductase activity
MF133_10495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MF133_10500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MF133_10505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MF133_10515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MF133_10520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MF133_10550	COG3964	amidohydrolase
MF133_10570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_10575	COG1660	Displays ATPase and GTPase activities
MF133_10580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_10590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MF133_10595	COG1137	ATPase activity
MF133_10600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MF133_10610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MF133_10615	COG0517	IMP dehydrogenase activity
MF133_10615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MF133_10620	COG1127	ABC transporter
MF133_10625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MF133_10630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MF133_10635	COG2854	intermembrane phospholipid transfer
MF133_10645	COG5007	Belongs to the BolA IbaG family
MF133_10650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MF133_10655	COG0312	modulator of DNA gyrase
MF133_10660	COG3028	Belongs to the UPF0307 family
MF133_10670	COG2926	Belongs to the UPF0265 family
MF133_10700	COG1396	sequence-specific DNA binding
MF133_10705	COG3135	benzoate transporter
MF133_10735	COG3047	cAMP biosynthetic process
MF133_10740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MF133_10745	COG2197	response regulator
MF133_10765	COG1278	Cold shock
MF133_10795	COG3706	GGDEF domain
MF133_10800	COG0347	Belongs to the P(II) protein family
MF133_10805	COG0004	ammonium transporteR
MF133_10815	COG0346	lactoylglutathione lyase activity
MF133_10825	COG1192	Involved in chromosome partitioning
MF133_10830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MF133_10835	COG1074	ATP-dependent DNA helicase activity
MF133_10840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MF133_10845	COG2259	Doxx family
MF133_10850	COG1741	Belongs to the pirin family
MF133_10860	COG0583	DNA-binding transcription factor activity
MF133_10885	COG1175	transmembrane transport
MF133_10895	COG3842	ATPase activity
MF133_10925	COG0456	acetyltransferase
MF133_10930	COG0753	catalase activity
MF133_10960	COG0628	permease
MF133_10970	COG2957	Belongs to the agmatine deiminase family
MF133_10985	COG2957	Belongs to the agmatine deiminase family
MF133_10990	COG0583	DNA-binding transcription factor activity
MF133_11005	COG1461	Dihydroxyacetone kinase
MF133_11010	COG2376	Dihydroxyacetone kinase
MF133_11015	COG2252	PERMEase
MF133_11020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MF133_11055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MF133_11060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MF133_11065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MF133_11070	COG0049	tRNA binding
MF133_11075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MF133_11080	COG2168	tRNA wobble position uridine thiolation
MF133_11090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MF133_11095	COG0251	oxidation-reduction process
MF133_11100	COG2964	Protein conserved in bacteria
MF133_11105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MF133_11110	COG0085	RNA polymerase activity
MF133_11115	COG0222	ribosome binding
MF133_11120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MF133_11125	COG0081	regulation of translation
MF133_11130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MF133_11135	COG0250	Participates in transcription elongation, termination and antitermination
MF133_11150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MF133_11175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MF133_11180	COG0569	domain protein
MF133_11185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MF133_11190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MF133_11195	COG3005	denitrification pathway
MF133_11200	COG0243	molybdopterin cofactor binding
MF133_11235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MF133_11245	COG2204	response regulator
MF133_11255	COG2205	protein histidine kinase activity
MF133_11275	COG0516	GMP reductase activity
MF133_11275	COG0517	IMP dehydrogenase activity
MF133_11285	COG1522	sequence-specific DNA binding
MF133_11290	COG2502	aspartate--ammonia ligase
MF133_11295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MF133_11300	COG0542	response to heat
MF133_11310	COG0564	pseudouridine synthase activity
MF133_11315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF133_11320	COG3681	Belongs to the UPF0597 family
MF133_11325	COG2964	Protein conserved in bacteria
MF133_11330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MF133_11335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MF133_11340	COG1979	alcohol dehydrogenase
MF133_11345	COG2207	Transcriptional regulator
MF133_11350	COG3040	lipid binding
MF133_11360	COG0840	transmembrane signaling receptor activity
MF133_11385	COG0540	Belongs to the ATCase OTCase family
MF133_11390	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MF133_11395	COG1438	arginine binding
MF133_11400	COG1288	antiporter activity
MF133_11405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MF133_11445	COG3250	beta-galactosidase activity
MF133_11450	COG1609	Transcriptional regulator
MF133_11455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MF133_11465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MF133_11470	COG2017	converts alpha-aldose to the beta-anomer
MF133_11475	COG0667	Aldo Keto reductase
MF133_11480	COG1968	undecaprenyl-diphosphatase activity
MF133_11485	COG3806	Anti-sigma factor
MF133_11490	COG1595	DNA-templated transcription, initiation
MF133_11510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MF133_11515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MF133_11520	COG2814	Major facilitator Superfamily
MF133_11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_11540	COG1131	(ABC) transporter
MF133_11545	COG0842	Transport permease protein
MF133_11550	COG0842	Transport permease protein
MF133_11555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MF133_11565	COG2116	formate transmembrane transporter activity
MF133_11570	COG1648	precorrin-2 dehydrogenase activity
MF133_11570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MF133_11575	COG2239	Acts as a magnesium transporter
MF133_11580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MF133_11585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MF133_11595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MF133_11605	COG0514	ATP-dependent DNA helicase (RecQ)
MF133_11610	COG2050	protein possibly involved in aromatic compounds catabolism
MF133_11625	COG2258	MOSC domain
MF133_11630	COG1177	transmembrane transport
MF133_11635	COG1176	ABC-type spermidine putrescine transport system, permease component I
MF133_11640	COG3842	ATPase activity
MF133_11660	COG0174	glutamine synthetase
MF133_11680	COG3045	CreA protein
MF133_11685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MF133_11690	COG0443	Heat shock 70 kDa protein
MF133_11705	COG0366	Alpha amylase catalytic
MF133_11715	COG4310	Domain of unknown function (DUF2172)
MF133_11750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MF133_11755	COG0745	RESPONSE REGULATOR receiver
MF133_11765	COG2205	protein histidine kinase activity
MF133_11775	COG0281	malic enzyme
MF133_11780	COG0702	epimerase
MF133_11785	COG0254	rRNA binding
MF133_11790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MF133_11795	COG1309	transcriptional regulator
MF133_11815	COG0129	dihydroxy-acid dehydratase activity
MF133_11825	COG3978	acetolactate synthase activity
MF133_11835	COG0606	chelatase, subunit chli
MF133_11840	COG0204	Acyl-transferase
MF133_11845	COG0204	Acyl-transferase
MF133_11850	COG1683	Conserved Protein
MF133_11860	COG1335	isochorismatase
MF133_11870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MF133_11875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MF133_11885	COG3084	Protein conserved in bacteria
MF133_11890	COG4251	negative regulation of phosphorylation
MF133_11890	COG5001	Diguanylate cyclase
MF133_11890	COG3706	GGDEF domain
MF133_11890	COG2203	Gaf domain
MF133_11905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MF133_11910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MF133_11915	COG1561	YicC-like family, N-terminal region
MF133_11925	COG1519	Transferase
MF133_11930	COG0859	PFAM glycosyl transferase family 9
MF133_11935	COG0463	Glycosyl transferase, family 2
MF133_11940	COG0859	PFAM glycosyl transferase family 9
MF133_11945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MF133_11950	COG2990	Protein conserved in bacteria
MF133_11955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MF133_11965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MF133_11970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MF133_11975	COG2003	Belongs to the UPF0758 family
MF133_11980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MF133_11985	COG0756	dUTP diphosphatase activity
MF133_11990	COG1309	transcriptional regulator
MF133_12010	COG0668	transmembrane transport
MF133_12020	COG0166	Belongs to the GPI family
MF133_12025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MF133_12030	COG0583	DNA-binding transcription factor activity
MF133_12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MF133_12040	COG1042	CoA-binding domain protein
MF133_12040	COG0045	succinate-CoA ligase (ADP-forming) activity
MF133_12075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MF133_12085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MF133_12090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MF133_12095	COG2223	nitrite transmembrane transporter activity
MF133_12100	COG3279	Response regulator of the LytR AlgR family
MF133_12105	COG3275	phosphorelay sensor kinase activity
MF133_12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_12115	COG2205	protein histidine kinase activity
MF133_12135	COG3188	usher protein
MF133_12150	COG1280	lysine exporter protein (LysE YggA)
MF133_12155	COG2223	nitrite transmembrane transporter activity
MF133_12160	COG2081	HI0933 family
MF133_12165	COG1528	Iron-storage protein
MF133_12170	COG3706	GGDEF domain
MF133_12175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MF133_12180	COG0589	response to stress
MF133_12220	COG3642	lipopolysaccharide core region biosynthetic process
MF133_12225	COG0859	PFAM glycosyl transferase family 9
MF133_12235	COG1758	RNA polymerase activity
MF133_12240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MF133_12245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF133_12255	COG2267	carboxylic ester hydrolase activity
MF133_12260	COG0561	phosphatase activity
MF133_12290	COG1309	transcriptional regulator
MF133_12295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_12300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF133_12305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_12305	COG4191	Histidine kinase
MF133_12310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF133_12330	COG2205	protein histidine kinase activity
MF133_12335	COG0745	RESPONSE REGULATOR receiver
MF133_12340	COG2814	Major facilitator Superfamily
MF133_12355	COG3977	Valine--pyruvate aminotransferase
MF133_12360	COG0071	Belongs to the small heat shock protein (HSP20) family
MF133_12365	COG0071	Belongs to the small heat shock protein (HSP20) family
MF133_12370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MF133_12375	COG2207	Transcriptional regulator
MF133_12380	COG0187	DNA topoisomerase II activity
MF133_12390	COG0592	DNA-directed DNA polymerase activity
MF133_12395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MF133_12410	COG1126	abc transporter atp-binding protein
MF133_12415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MF133_12420	COG0594	ribonuclease P activity
MF133_12425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MF133_12430	COG0706	membrane insertase activity
MF133_12435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MF133_12440	COG4974	Belongs to the 'phage' integrase family
MF133_12525	COG3173	Aminoglycoside phosphotransferase
MF133_12530	COG0488	(ABC) transporter
MF133_12540	COG3173	Aminoglycoside phosphotransferase
MF133_12590	COG1357	PFAM Pentapeptide repeats (8 copies)
MF133_12605	COG3550	peptidyl-serine autophosphorylation
MF133_12615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MF133_12620	COG1120	ATPase activity
MF133_12625	COG4615	Cyclic peptide transporter
MF133_12630	COG4774	siderophore transport
MF133_12635	COG0716	FMN binding
MF133_12640	COG0445	tRNA wobble uridine modification
MF133_12645	COG0357	Ribosomal RNA small subunit methyltransferase G
MF133_12650	COG1192	Involved in chromosome partitioning
MF133_12655	COG1475	DNA binding
MF133_12665	COG0356	it plays a direct role in the translocation of protons across the membrane
MF133_12675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MF133_12680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MF133_12685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MF133_12690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MF133_12695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MF133_12700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MF133_12705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MF133_12710	COG4452	Inner membrane protein CreD
MF133_12725	COG0745	RESPONSE REGULATOR receiver
MF133_12730	COG1349	DNA-binding transcription factor activity
MF133_12735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MF133_12740	COG2771	luxR family
MF133_12750	COG0811	peptide transport
MF133_12755	COG0811	peptide transport
MF133_12760	COG0848	biopolymer transport protein
MF133_12765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MF133_12800	COG0402	S-adenosylhomocysteine deaminase activity
MF133_12805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MF133_12815	COG3165	ubiquinone biosynthetic process from chorismate
MF133_12820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MF133_12825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MF133_12830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MF133_12835	COG0805	protein transport
MF133_12840	COG0084	hydrolase, TatD family'
MF133_12860	COG0742	ribosomal rna small subunit methyltransferase
MF133_12870	COG0248	Ppx GppA phosphatase
MF133_12875	COG0513	Belongs to the DEAD box helicase family
MF133_12880	COG3118	belongs to the thioredoxin family
MF133_12895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MF133_12905	COG2960	long-chain fatty acid transporting porin activity
MF133_12920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MF133_12960	COG1609	Transcriptional regulator
MF133_12965	COG3604	Transcriptional regulator
MF133_12975	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF133_12985	COG0348	domain, Protein
MF133_12995	COG3033	Beta-eliminating lyase
MF133_13000	COG0814	amino acid
MF133_13005	COG0814	amino acid
MF133_13020	COG3706	GGDEF domain
MF133_13020	COG4251	negative regulation of phosphorylation
MF133_13020	COG2203	Gaf domain
MF133_13020	COG5001	Diguanylate cyclase
MF133_13030	COG0751	glycine-tRNA ligase activity
MF133_13035	COG0752	glycyl-tRNA synthetase alpha subunit
MF133_13040	COG2818	Glycosylase
MF133_13045	COG1335	isochorismatase
MF133_13065	COG0251	oxidation-reduction process
MF133_13070	COG0425	Belongs to the sulfur carrier protein TusA family
MF133_13100	COG0183	Belongs to the thiolase family
MF133_13105	COG1024	Enoyl-CoA hydratase
MF133_13105	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF133_13110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MF133_13115	COG0006	proline dipeptidase activity
MF133_13120	COG1739	Uncharacterized protein family UPF0029
MF133_13125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MF133_13130	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MF133_13165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MF133_13170	COG2166	iron-sulfur cluster assembly
MF133_13175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MF133_13195	COG1063	alcohol dehydrogenase
MF133_13200	COG0156	8-amino-7-oxononanoate synthase activity
MF133_13210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MF133_13225	COG3306	glycosyltransferase involved in LPS biosynthesis
MF133_13260	COG1609	Transcriptional regulator
MF133_13275	COG1580	Controls the rotational direction of flagella during chemotaxis
MF133_13280	COG3161	chorismate lyase activity
MF133_13285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MF133_13290	COG2937	Belongs to the GPAT DAPAT family
MF133_13295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MF133_13310	COG0534	Mate efflux family protein
MF133_13315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MF133_13320	COG2205	protein histidine kinase activity
MF133_13325	COG0745	RESPONSE REGULATOR receiver
MF133_13335	COG1045	serine acetyltransferase
MF133_13345	COG3074	FtsZ-dependent cytokinesis
MF133_13350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MF133_13360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MF133_13400	COG1609	Transcriptional regulator
MF133_13405	COG3250	beta-galactosidase activity
MF133_13410	COG2731	YhcH YjgK YiaL family protein
MF133_13415	COG0531	amino acid
MF133_13420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF133_13425	COG0531	amino acid
MF133_13430	COG0385	Bile acid
MF133_13435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MF133_13460	COG0583	DNA-binding transcription factor activity
MF133_13465	COG1079	Belongs to the binding-protein-dependent transport system permease family
MF133_13470	COG4603	Belongs to the binding-protein-dependent transport system permease family
MF133_13475	COG3845	ABC transporter
MF133_13480	COG1744	ABC transporter substrate-binding protein PnrA-like
MF133_13495	COG0210	DNA helicase
MF133_13520	COG0583	DNA-binding transcription factor activity
MF133_13555	COG0583	DNA-binding transcription factor activity
MF133_13570	COG1280	lysine exporter protein (LysE YggA)
MF133_13580	COG2962	Rard protein
MF133_13590	COG1012	belongs to the aldehyde dehydrogenase family
MF133_13595	COG1396	sequence-specific DNA binding
MF133_13600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MF133_13610	COG0519	Catalyzes the synthesis of GMP from XMP
MF133_13610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MF133_13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF133_13640	COG1322	Protein conserved in bacteria
MF133_13645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MF133_13650	COG0569	domain protein
MF133_13655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MF133_13655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MF133_13660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MF133_13665	COG0242	peptide deformylase activity
MF133_13675	COG0758	DNA mediated transformation
MF133_13680	COG2922	Belongs to the Smg family
MF133_13685	COG0551	DNA topoisomerase type I activity
MF133_13690	COG0009	L-threonylcarbamoyladenylate synthase
MF133_13695	COG0408	coproporphyrinogen oxidase activity
MF133_13700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MF133_13705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MF133_13715	COG3078	GTPase activator activity
MF133_13725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MF133_13730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MF133_13740	COG3852	Histidine kinase
MF133_13750	COG0174	glutamine synthetase
MF133_13755	COG1217	gtp-binding protein TYPA
MF133_13760	COG1295	ribonuclease BN
MF133_13765	COG1490	D-aminoacyl-tRNA deacylase activity
MF133_13775	COG0456	acetyltransferase
MF133_13785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MF133_13790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MF133_13795	COG2610	gluconate transmembrane transporter activity
MF133_13800	COG3265	gluconokinase activity
MF133_13805	COG0129	dihydroxy-acid dehydratase activity
MF133_13810	COG0800	Aldolase
MF133_13835	COG4942	peptidase
MF133_13840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MF133_13845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MF133_13850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MF133_13855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MF133_13860	COG0316	Belongs to the HesB IscA family
MF133_13860	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MF133_13865	COG1040	competence protein
MF133_13870	COG0596	Alpha beta hydrolase
MF133_13885	COG2183	response to ionizing radiation
MF133_13890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MF133_13900	COG2205	protein histidine kinase activity
MF133_13910	COG0051	transcription antitermination factor activity, RNA binding
MF133_13915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MF133_13920	COG0088	Forms part of the polypeptide exit tunnel
MF133_13925	COG0089	rRNA binding
MF133_13930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MF133_13935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MF133_13940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MF133_13945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MF133_13950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MF133_13955	COG0255	Belongs to the universal ribosomal protein uL29 family
MF133_13960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MF133_13965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MF133_13970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MF133_13975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MF133_13980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MF133_13985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MF133_13990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MF133_13995	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MF133_14000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MF133_14005	COG1841	ribosomal large subunit assembly
MF133_14010	COG0200	Binds to the 23S rRNA
MF133_14015	COG0201	protein transport
MF133_14020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MF133_14025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MF133_14030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MF133_14035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MF133_14040	COG0202	RNA polymerase activity
MF133_14045	COG0203	ribosomal protein L17
MF133_14090	COG2249	NAD(P)H dehydrogenase (quinone) activity
MF133_14095	COG0583	DNA-binding transcription factor activity
MF133_14100	COG4221	oxidoreductase activity
MF133_14115	COG1770	oligopeptidase
MF133_14120	COG2358	TRAP transporter, solute receptor (TAXI family
MF133_14135	COG3714	YhhN family
MF133_14150	COG0583	DNA-binding transcription factor activity
MF133_14160	COG1301	dicarboxylic acid transport
MF133_14170	COG2095	MarC family integral membrane protein
MF133_14180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MF133_14190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MF133_14200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MF133_14225	COG0742	ribosomal rna small subunit methyltransferase
MF133_14230	COG0552	protein localization to endoplasmic reticulum
MF133_14235	COG2884	Cell division ATP-binding protein ftsE
MF133_14240	COG2177	Part of the ABC transporter FtsEX involved in
MF133_14250	COG0288	reversible hydration of carbon dioxide
MF133_14255	COG2188	Transcriptional regulator
MF133_14260	COG1228	amidohydrolase
MF133_14265	COG0010	Belongs to the arginase family
MF133_14270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MF133_14275	COG2986	histidine ammonia-lyase
MF133_14280	COG0387	Pfam Sodium calcium exchanger
MF133_14285	COG2200	EAL domain
MF133_14335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MF133_14340	COG1459	type II secretion system
MF133_14390	COG1792	Involved in formation and maintenance of cell shape
MF133_14395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MF133_14400	COG0424	maF-like protein
MF133_14405	COG1530	ribonuclease E activity
MF133_14410	COG3164	Protein of unknown function
MF133_14415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF133_14420	COG0312	modulator of DNA gyrase
MF133_14435	COG0477	Major facilitator Superfamily
MF133_14445	COG3437	response regulator, receiver
MF133_14450	COG0784	Response regulator, receiver
MF133_14450	COG2205	protein histidine kinase activity
MF133_14450	COG5002	protein histidine kinase activity
MF133_14455	COG2172	sigma factor antagonist activity
MF133_14460	COG1366	Belongs to the anti-sigma-factor antagonist family
MF133_14470	COG3700	Belongs to the class B bacterial acid phosphatase family
MF133_14475	COG2321	neutral zinc metallopeptidase
MF133_14510	COG0189	ligase activity
MF133_14515	COG0642	Histidine kinase
MF133_14520	COG0745	RESPONSE REGULATOR receiver
MF133_14535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MF133_14540	COG0352	thiamine-phosphate diphosphorylase activity
MF133_14545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MF133_14575	COG0110	maltose O-acetyltransferase activity
MF133_14590	COG3932	Exopolysaccharide synthesis, ExoD
MF133_14605	COG1733	regulation of RNA biosynthetic process
MF133_14630	COG2226	methyltransferase
MF133_14640	COG1494	fructose-1,6-bisphosphatase
MF133_14650	COG3071	HemY protein
MF133_14655	COG2959	enzyme of heme biosynthesis
MF133_14665	COG0181	hydroxymethylbilane synthase activity
MF133_14670	COG3072	Adenylate cyclase
MF133_14675	COG0400	carboxylic ester hydrolase activity
MF133_14680	COG1965	Belongs to the frataxin family
MF133_14690	COG0019	diaminopimelate decarboxylase activity
MF133_14695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MF133_14710	COG1011	Hydrolase
MF133_14720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MF133_14725	COG0561	phosphatase activity
MF133_14740	COG1988	membrane-bound metal-dependent
MF133_14745	COG1546	Belongs to the CinA family
MF133_14745	COG1058	Belongs to the CinA family
MF133_14755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MF133_14765	COG1522	sequence-specific DNA binding
MF133_14770	COG1368	sulfuric ester hydrolase activity
MF133_14785	COG1285	pathogenesis
MF133_14805	COG4221	oxidoreductase activity
MF133_14820	COG1979	alcohol dehydrogenase
MF133_14830	COG2873	o-acetylhomoserine
MF133_14860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MF133_14870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MF133_14875	COG2949	membrane
MF133_14880	COG3291	Pkd domain containing protein
MF133_14885	COG0318	PFAM AMP-dependent synthetase and ligase
MF133_14895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MF133_14900	COG0596	Alpha beta hydrolase
MF133_14905	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MF133_14910	COG1169	isochorismate synthase
MF133_14915	COG1575	Belongs to the MenA family. Type 1 subfamily
MF133_14935	COG0513	Belongs to the DEAD box helicase family
MF133_14940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MF133_14955	COG1671	Belongs to the UPF0178 family
MF133_14975	COG3263	regulation of cellular component size
MF133_14980	COG3722	fumarate hydratase activity
MF133_14985	COG0246	Mannitol dehydrogenase
MF133_14990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF133_14990	COG2213	PTS system mannitol-specific
MF133_14995	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MF133_15005	COG3916	Acyl-homoserine-lactone synthase
MF133_15010	COG2771	luxR family
MF133_15025	COG1560	Kdo2-lipid A biosynthetic process
MF133_15030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MF133_15030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MF133_15035	COG1538	Outer membrane efflux protein
MF133_15040	COG0494	nUDIX hydrolase
MF133_15045	COG3151	Protein conserved in bacteria
MF133_15060	COG3150	esterase
MF133_15065	COG1051	belongs to the nudix hydrolase family
MF133_15080	COG1566	PFAM secretion protein HlyD family protein
MF133_15085	COG1289	transmembrane transporter activity
MF133_15155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF133_15180	COG0204	Acyl-transferase
MF133_15185	COG1842	Phage shock protein A
MF133_15200	COG2827	Endonuclease containing a URI domain
MF133_15205	COG2962	Rard protein
MF133_15210	COG1573	uracil-dna glycosylase
MF133_15220	COG0583	DNA-binding transcription factor activity
MF133_15225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MF133_15230	COG1121	(ABC) transporter
MF133_15235	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MF133_15255	COG0739	heme binding
MF133_15265	COG3068	Protein conserved in bacteria
MF133_15285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MF133_15295	COG1546	Belongs to the CinA family
MF133_15300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MF133_15305	COG2137	regulation of response to DNA damage stimulus
MF133_15310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MF133_15315	COG0527	aspartate kinase activity
MF133_15320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MF133_15355	COG1686	Belongs to the peptidase S11 family
MF133_15360	COG0586	Pfam SNARE associated Golgi protein
MF133_15365	COG1253	flavin adenine dinucleotide binding
MF133_15370	COG0525	valine-tRNA ligase activity
MF133_15375	COG2927	DNA polymerase III (CHI subunit)
MF133_15380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MF133_15385	COG0795	lipopolysaccharide-transporting ATPase activity
MF133_15390	COG0795	lipopolysaccharide-transporting ATPase activity
MF133_15410	COG0004	ammonium transporteR
MF133_15415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MF133_15430	COG2165	general secretion pathway protein
MF133_15435	COG0084	hydrolase, TatD family'
MF133_15440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MF133_15450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MF133_15455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MF133_15460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MF133_15465	COG0813	purine-nucleoside phosphorylase activity
MF133_15470	COG3447	MASE1 domain protein
MF133_15470	COG5001	Diguanylate cyclase
MF133_15470	COG5002	protein histidine kinase activity
MF133_15480	COG0560	Phosphoserine phosphatase
MF133_15495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MF133_15505	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MF133_15510	COG0776	regulation of translation
MF133_15525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MF133_15575	COG0735	belongs to the Fur family
MF133_15595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MF133_15600	COG0513	Belongs to the DEAD box helicase family
MF133_15605	COG3022	response to hydroperoxide
MF133_15620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MF133_15625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MF133_15630	COG0762	integral membrane protein
MF133_15635	COG1872	DUF167
MF133_15655	COG3112	Uncharacterised protein family (UPF0231)
MF133_15660	COG3835	regulator
MF133_15665	COG2610	gluconate transmembrane transporter activity
MF133_15670	COG1929	Belongs to the glycerate kinase type-1 family
MF133_15685	COG0583	DNA-binding transcription factor activity
MF133_15705	COG0347	Belongs to the P(II) protein family
MF133_15710	COG1840	ABC-type Fe3 transport system, periplasmic component
MF133_15720	COG3842	ATPase activity
MF133_15725	COG2837	iron assimilation
MF133_15730	COG1438	arginine binding
MF133_15735	COG1126	abc transporter atp-binding protein
MF133_15740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_15745	COG4215	(ABC) transporter
MF133_15750	COG4160	amino acid transport
MF133_15755	COG0039	L-malate dehydrogenase activity
MF133_15760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MF133_15765	COG1017	nitric oxide dioxygenase activity
MF133_15765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MF133_15775	COG4536	flavin adenine dinucleotide binding
MF133_15780	COG4137	Cytochrome C assembly protein
MF133_15785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MF133_15790	COG0228	four-way junction DNA binding
MF133_15795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MF133_15800	COG0336	Belongs to the RNA methyltransferase TrmD family
MF133_15805	COG0335	large ribosomal subunit rRNA binding
MF133_15825	COG1051	belongs to the nudix hydrolase family
MF133_15835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MF133_15840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MF133_15845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF133_15855	COG0583	DNA-binding transcription factor activity
MF133_15860	COG0640	Transcriptional regulator
MF133_15865	COG0268	Binds directly to 16S ribosomal RNA
MF133_15870	COG0728	peptidoglycan biosynthetic process
MF133_15875	COG0196	riboflavin kinase activity
MF133_15880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MF133_15885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MF133_15890	COG1047	Peptidyl-prolyl cis-trans
MF133_15895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MF133_15935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MF133_15935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF133_15950	COG1854	S-ribosylhomocysteine lyase activity
MF133_15955	COG3706	GGDEF domain
MF133_15960	COG0557	exoribonuclease II activity
MF133_15965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF133_15975	COG2153	protein acetylation
MF133_15985	COG1914	H( )-stimulated, divalent metal cation uptake system
MF133_15990	COG0360	Binds together with S18 to 16S ribosomal RNA
MF133_15995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MF133_16000	COG0359	binds to the 23S rRNA
MF133_16040	COG1238	metal cluster binding
MF133_16045	COG0612	Peptidase, M16
MF133_16050	COG2918	glutathione biosynthetic process
MF133_16055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MF133_16060	COG1027	Aspartate ammonia-lyase
MF133_16065	COG3030	protein affecting phage T7 exclusion by the F plasmid
MF133_16070	COG0534	Mate efflux family protein
MF133_16075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MF133_16080	COG0459	protein refolding
MF133_16100	COG0564	pseudouridine synthase activity
MF133_16105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MF133_16140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MF133_16150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MF133_16155	COG4208	sulfate ABC transporter
MF133_16160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MF133_16165	COG0583	DNA-binding transcription factor activity
MF133_16170	COG3397	chitin binding
MF133_16200	COG1328	CTP reductase activity
MF133_16205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MF133_16220	COG1448	Aminotransferase
MF133_16225	COG2194	sulfuric ester hydrolase activity
MF133_16240	COG1215	transferase activity, transferring glycosyl groups
MF133_16245	COG1215	transferase activity, transferring glycosyl groups
MF133_16250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MF133_16255	COG3118	belongs to the thioredoxin family
MF133_16255	COG0457	Tetratricopeptide repeat
MF133_16300	COG0513	Belongs to the DEAD box helicase family
MF133_16305	COG0840	transmembrane signaling receptor activity
MF133_16315	COG4166	transmembrane transport
MF133_16330	COG1024	Enoyl-CoA hydratase
MF133_16345	COG4221	oxidoreductase activity
MF133_16350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MF133_16355	COG0442	prolyl-tRNA aminoacylation
MF133_16360	COG0840	transmembrane signaling receptor activity
MF133_16365	COG0632	four-way junction helicase activity
MF133_16370	COG2255	four-way junction helicase activity
MF133_16375	COG1271	oxidase subunit
MF133_16380	COG1294	oxidase, subunit
MF133_16385	COG4890	Cyd operon protein YbgT
MF133_16390	COG3790	cyd operon protein YbgE
MF133_16395	COG0824	Thioesterase
MF133_16400	COG0811	peptide transport
MF133_16415	COG0823	Involved in the tonB-independent uptake of proteins
MF133_16420	COG2885	chlorophyll binding
MF133_16425	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MF133_16500	COG0840	transmembrane signaling receptor activity
MF133_16505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MF133_16515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MF133_16520	COG1640	4-alpha-glucanotransferase
MF133_16525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MF133_16555	COG2130	NADP-dependent
MF133_16560	COG1846	Transcriptional regulator
MF133_16590	COG0561	phosphatase activity
MF133_16605	COG0733	neurotransmitter:sodium symporter activity
MF133_16610	COG0733	neurotransmitter:sodium symporter activity
MF133_16625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF133_16640	COG1794	racemase activity, acting on amino acids and derivatives
MF133_16650	COG1022	Amp-dependent synthetase and ligase
MF133_16660	COG0456	acetyltransferase
MF133_16675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MF133_16680	COG5002	protein histidine kinase activity
MF133_16680	COG5001	Diguanylate cyclase
MF133_16700	COG0456	acetyltransferase
MF133_16715	COG1902	pentaerythritol trinitrate reductase activity
MF133_16735	COG2957	Belongs to the agmatine deiminase family
MF133_16740	COG0154	amidase activity
MF133_16770	COG1917	Cupin 2, conserved barrel domain protein
MF133_16770	COG2207	Transcriptional regulator
MF133_16780	COG0513	Belongs to the DEAD box helicase family
MF133_16785	COG2203	Gaf domain
MF133_16785	COG2199	diguanylate cyclase activity
MF133_16820	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
MF133_16830	COG1136	(ABC) transporter
MF133_16830	COG0577	efflux transmembrane transporter activity
MF133_16835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_16840	COG0745	RESPONSE REGULATOR receiver
MF133_16845	COG2205	protein histidine kinase activity
MF133_16895	COG1280	lysine exporter protein (LysE YggA)
MF133_16950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MF133_16965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF133_16995	COG0745	RESPONSE REGULATOR receiver
MF133_17000	COG3104	oligopeptide transport
MF133_17005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MF133_17010	COG1555	photosystem II stabilization
MF133_17020	COG2350	Protein conserved in bacteria
MF133_17025	COG2917	probably involved in intracellular septation
MF133_17030	COG0076	glutamate decarboxylase activity
MF133_17035	COG1272	protein, Hemolysin III
MF133_17040	COG2985	domain, Protein
MF133_17040	COG0569	domain protein
MF133_17050	COG0477	Major facilitator Superfamily
MF133_17055	COG0583	DNA-binding transcription factor activity
MF133_17060	COG3227	Zinc metalloprotease (Elastase)
MF133_17065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MF133_17070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MF133_17080	COG2731	YhcH YjgK YiaL family protein
MF133_17090	COG0668	transmembrane transport
MF133_17100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF133_17110	COG0789	Transcriptional regulator
MF133_17120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MF133_17165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MF133_17175	COG0488	(ABC) transporter
MF133_17180	COG0516	GMP reductase activity
MF133_17180	COG0517	IMP dehydrogenase activity
MF133_17190	COG0784	Response regulator, receiver
MF133_17190	COG0835	chemotaxis
MF133_17195	COG2755	lipolytic protein G-D-S-L family
MF133_17200	COG4181	ATPase activity
MF133_17205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MF133_17210	COG1090	epimerase
MF133_17215	COG2200	EAL domain
MF133_17225	COG2234	aminopeptidase activity
MF133_17230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MF133_17235	COG3171	Protein conserved in bacteria
MF133_17240	COG2066	Belongs to the glutaminase family
MF133_17245	COG2897	thiosulfate sulfurtransferase activity
MF133_17250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF133_17285	COG1132	(ABC) transporter
MF133_17310	COG0582	viral genome integration into host DNA
MF133_17340	COG1902	pentaerythritol trinitrate reductase activity
MF133_17360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MF133_17370	COG4974	Belongs to the 'phage' integrase family
MF133_17450	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
MF133_17455	COG5001	Diguanylate cyclase
MF133_17455	COG3300	MHYT domain
MF133_17475	COG4628	conserved protein (DUF2132)
MF133_17480	COG0688	phosphatidylethanolamine metabolic process
MF133_17485	COG1162	GTPase activity
MF133_17490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MF133_17530	COG0582	viral genome integration into host DNA
MF133_17540	COG1396	sequence-specific DNA binding
MF133_17545	COG0583	DNA-binding transcription factor activity
MF133_17550	COG0589	response to stress
MF133_17555	COG0659	secondary active sulfate transmembrane transporter activity
MF133_17560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF133_17565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF133_17570	COG0785	Cytochrome C biogenesis protein
MF133_17600	COG3220	belongs to the UPF0276 family
MF133_17620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF133_17635	COG3039	Transposase
MF133_17645	COG1595	DNA-templated transcription, initiation
MF133_17650	COG0431	NADPH-dependent FMN reductase
MF133_17660	COG0798	PFAM Bile acid sodium symporter
MF133_17685	COG0640	Transcriptional regulator
MF133_17735	COG2003	Belongs to the UPF0758 family
MF133_17955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MF133_18100	COG0629	single-stranded DNA binding
MF133_18150	COG1278	Cold shock
MF133_18160	COG0840	transmembrane signaling receptor activity
MF133_18165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF133_18170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF133_18220	COG0848	biopolymer transport protein
MF133_18225	COG0811	peptide transport
MF133_18230	COG0811	peptide transport
MF133_18240	COG4206	TonB-dependent receptor
MF133_18245	COG4174	ABC transporter (Permease)
MF133_18250	COG4239	(ABC) transporter, permease
MF133_18260	COG0444	Belongs to the ABC transporter superfamily
MF133_18265	COG4608	Belongs to the ABC transporter superfamily
MF133_18270	COG2195	Cleaves the N-terminal amino acid of tripeptides
MF133_18430	COG4695	Portal protein
MF133_18515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MF133_18530	COG4974	Belongs to the 'phage' integrase family
MF133_18535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MF133_18540	COG1073	alpha beta
MF133_18555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MF133_18580	COG0243	molybdopterin cofactor binding
MF133_18600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MF133_18600	COG1116	anion transmembrane transporter activity
MF133_18605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF133_18610	COG1116	anion transmembrane transporter activity
MF133_18615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MF133_18615	COG2146	nitrite reductase [NAD(P)H] activity
MF133_18620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MF133_18620	COG2146	nitrite reductase [NAD(P)H] activity
MF133_18625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF133_18630	COG2313	pseudouridylate synthase activity
MF133_18655	COG0521	Mo-molybdopterin cofactor biosynthetic process
MF133_18665	COG2966	Psort location CytoplasmicMembrane, score
MF133_18670	COG3610	response to peptide
MF133_18680	COG4175	Glycine betaine
MF133_18685	COG4176	ABC-type proline glycine betaine transport system permease component
MF133_18690	COG2113	Glycine betaine
MF133_18695	COG0175	sulfate reduction
MF133_18700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MF133_18705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MF133_18710	COG0384	phenazine biosynthesis protein PhzF
MF133_18715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MF133_18730	COG0786	glutamate:sodium symporter activity
MF133_18740	COG3139	Protein of unknown function (DUF1315)
MF133_18760	COG0616	signal peptide processing
MF133_18770	COG0778	Nitroreductase
MF133_18785	COG0110	maltose O-acetyltransferase activity
MF133_18790	COG2264	protein methyltransferase activity
MF133_18795	COG0604	alcohol dehydrogenase
MF133_18800	COG0583	DNA-binding transcription factor activity
MF133_18805	COG2190	(PTS) system
MF133_18805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_18805	COG1263	PTS System
MF133_18810	COG4145	pantothenate transmembrane transporter activity
MF133_18815	COG3924	membrane
MF133_18820	COG0439	Biotin carboxylase
MF133_18825	COG0511	ligase activity, forming carbon-carbon bonds
MF133_18830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MF133_18835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MF133_18850	COG3381	protein complex oligomerization
MF133_18860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MF133_18870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MF133_18875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MF133_18875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MF133_18890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MF133_18895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MF133_18900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MF133_18905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MF133_18910	COG4172	Belongs to the ABC transporter superfamily
MF133_18920	COG0601	transmembrane transport
MF133_18925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF133_18930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MF133_18935	COG0142	geranyltranstransferase activity
MF133_18940	COG1722	exodeoxyribonuclease VII activity
MF133_18945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MF133_18950	COG1360	Flagellar Motor Protein
MF133_18965	COG1534	Rna-binding protein
MF133_18970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MF133_18980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MF133_18985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MF133_18990	COG0149	triose-phosphate isomerase activity
MF133_18995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MF133_19010	COG0779	Required for maturation of 30S ribosomal subunits
MF133_19015	COG0195	Participates in both transcription termination and antitermination
MF133_19020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MF133_19025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MF133_19030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MF133_19035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MF133_19040	COG1185	polyribonucleotide nucleotidyltransferase activity
MF133_19045	COG2211	Major facilitator Superfamily
MF133_19050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MF133_19055	COG1422	Protein of unknown function (DUF1090)
MF133_19060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MF133_19065	COG0826	peptidase U32
MF133_19085	COG0312	modulator of DNA gyrase
MF133_19090	COG0312	modulator of DNA gyrase
MF133_19100	COG4974	Belongs to the 'phage' integrase family
MF133_19105	COG1970	mechanosensitive ion channel activity
MF133_19115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MF133_19120	COG0789	Transcriptional regulator
MF133_19135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MF133_19175	COG0270	DNA (cytosine-5-)-methyltransferase activity
MF133_19190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MF133_19195	COG0321	lipoyl(octanoyl) transferase activity
MF133_19200	COG2921	Belongs to the UPF0250 family
MF133_19205	COG1686	Belongs to the peptidase S11 family
MF133_19210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MF133_19215	COG2951	lytic endotransglycosylase activity
MF133_19220	COG0772	Belongs to the SEDS family
MF133_19225	COG0768	penicillin binding
MF133_19230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MF133_19235	COG0799	negative regulation of ribosome biogenesis
MF133_19240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MF133_19265	COG0495	leucyl-tRNA aminoacylation
MF133_19270	COG2888	peptidyl-tyrosine sulfation
MF133_19275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MF133_19280	COG4535	Mg2 and Co2 transporter CorC
MF133_19285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MF133_19290	COG1702	phosphate starvation-inducible protein PhoH
MF133_19295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MF133_19300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF133_19305	COG1335	isochorismatase
MF133_19320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF133_19325	COG2199	diguanylate cyclase activity
MF133_19335	COG2199	diguanylate cyclase activity
MF133_19345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MF133_19360	COG1464	Belongs to the NlpA lipoprotein family
MF133_19370	COG2011	ABC-type metal ion transport system permease component
MF133_19375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MF133_19385	COG0516	GMP reductase activity
MF133_19390	COG0189	ligase activity
MF133_19390	COG4067	protein conserved in archaea
MF133_19410	COG0300	oxidoreductase activity
MF133_19430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MF133_19435	COG3214	Protein conserved in bacteria
MF133_19450	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MF133_19455	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MF133_19460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MF133_19465	COG1053	succinate dehydrogenase
MF133_19475	COG0584	glycerophosphoryl diester phosphodiesterase
MF133_19480	COG1511	domain protein
MF133_19480	COG3264	Mechanosensitive ion channel
MF133_19505	COG0583	DNA-binding transcription factor activity
MF133_19520	COG0583	DNA-binding transcription factor activity
MF133_19525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MF133_19555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MF133_19560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MF133_19570	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MF133_19575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MF133_19580	COG0546	phosphoglycolate phosphatase activity
MF133_19585	COG0180	Tryptophanyl-tRNA synthetase
MF133_19600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MF133_19610	COG1012	belongs to the aldehyde dehydrogenase family
MF133_19625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF133_19640	COG0657	acetylesterase activity
MF133_19650	COG0490	domain, Protein
MF133_19650	COG0471	metal ion transport
MF133_19695	COG0012	GTP binding
MF133_19700	COG0193	aminoacyl-tRNA hydrolase activity
MF133_19705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MF133_19715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MF133_19720	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MF133_19725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MF133_19730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MF133_19735	COG2890	protein-(glutamine-N5) methyltransferase activity
MF133_19745	COG2912	Transglutaminase-like superfamily
MF133_19750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MF133_19755	COG1301	dicarboxylic acid transport
MF133_19765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MF133_19780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MF133_19785	COG1115	amino acid carrier protein
MF133_19805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MF133_19815	COG0189	ligase activity
MF133_19820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MF133_19830	COG3091	SprT-like family
MF133_19840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MF133_19865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MF133_19870	COG0739	heme binding
MF133_19875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MF133_19880	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MF133_19880	COG3408	Glycogen debranching enzyme
MF133_19890	COG1881	PFAM PEBP family protein
MF133_19895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MF133_19900	COG0583	DNA-binding transcription factor activity
MF133_19910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MF133_19920	COG0583	DNA-binding transcription factor activity
MF133_19925	COG1028	Short-chain dehydrogenase reductase Sdr
MF133_19930	COG0616	signal peptide processing
MF133_19935	COG3724	N-succinylarginine dihydrolase activity
MF133_19955	COG0840	transmembrane signaling receptor activity
MF133_19965	COG2971	BadF BadG BcrA BcrD
MF133_19975	COG4608	Belongs to the ABC transporter superfamily
MF133_19980	COG0444	Belongs to the ABC transporter superfamily
MF133_19985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF133_20000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MF133_20010	COG0640	Transcriptional regulator
MF133_20015	COG0798	PFAM Bile acid sodium symporter
MF133_20020	COG1393	Belongs to the ArsC family
MF133_20030	COG1677	Flagellar hook-basal body complex protein FliE
MF133_20040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MF133_20095	COG1684	flagellar biosynthetic protein fliR
MF133_20105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MF133_20130	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MF133_20135	COG0643	Histidine kinase
MF133_20135	COG0784	Response regulator, receiver
MF133_20135	COG2198	Histidine kinase
MF133_20140	COG2201	protein-glutamate methylesterase activity
MF133_20155	COG1192	Involved in chromosome partitioning
MF133_20165	COG0835	chemotaxis
MF133_20180	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MF133_20185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MF133_20190	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MF133_20195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MF133_20200	COG1138	Cytochrome C-type biogenesis protein
MF133_20205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF133_20215	COG0457	Tetratricopeptide repeat
MF133_20230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MF133_20235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MF133_20235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MF133_20250	COG0259	pyridoxamine-phosphate oxidase activity
MF133_20260	COG1473	amidohydrolase
MF133_20280	COG3153	acetyltransferase
MF133_20295	COG0800	Aldolase
MF133_20300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF133_20310	COG2721	sulfolactate sulfo-lyase activity
MF133_20315	COG0246	Mannitol dehydrogenase
MF133_20425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MF133_20690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MF133_20695	COG2867	negative regulation of translational initiation
MF133_20700	COG2914	Belongs to the UPF0125 (RnfH) family
MF133_20705	COG0702	epimerase
MF133_20710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF133_20720	COG2932	Transcriptional regulator
MF133_20785	COG2856	Zn peptidase
MF133_20820	COG0640	Transcriptional regulator
MF133_20830	COG4373	Mu-like prophage FluMu protein gp28
MF133_20835	COG4383	Mu-like prophage protein gp29
MF133_20855	COG4388	Caudovirus prohead serine protease
MF133_20860	COG4397	Mu-like prophage major head subunit gpT
MF133_20950	COG1957	nucleoside hydrolase
MF133_20975	COG1280	lysine exporter protein (LysE YggA)
MF133_20985	COG3263	regulation of cellular component size
MF133_20995	COG1876	peptidase activity
MF133_21000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MF133_21005	COG1393	Belongs to the ArsC family
MF133_21015	COG3069	C4-dicarboxylate transmembrane transporter activity
MF133_21020	COG1473	amidohydrolase
MF133_21035	COG0017	Asparaginyl-tRNA synthetase
MF133_21055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MF133_21060	COG0156	8-amino-7-oxononanoate synthase activity
MF133_21065	COG1073	alpha beta
MF133_21065	COG2226	methyltransferase
MF133_21070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MF133_21075	COG0501	Belongs to the peptidase M48B family
MF133_21080	COG0633	Ferredoxin
MF133_21080	COG0633	Ferredoxin
MF133_21080	COG3217	Mosc domain protein beta barrel domain protein
MF133_21080	COG3217	Mosc domain protein beta barrel domain protein
MF133_21090	COG0674	pyruvate-flavodoxin oxidoreductase activity
MF133_21090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MF133_21090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MF133_21090	COG1013	pyruvate-flavodoxin oxidoreductase activity
MF133_21095	COG2841	Protein conserved in bacteria
MF133_21105	COG0534	Mate efflux family protein
MF133_21140	COG1309	transcriptional regulator
MF133_21155	COG0791	NLP P60 protein
MF133_21160	COG0583	DNA-binding transcription factor activity
MF133_21180	COG0500	methyltransferase
MF133_21185	COG4106	trans-aconitate 2-methyltransferase activity
MF133_21190	COG1801	Protein of unknown function DUF72
MF133_21195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MF133_21200	COG0217	transcriptional regulatory protein
MF133_21205	COG2194	sulfuric ester hydrolase activity
MF133_21215	COG1940	carbohydrate kinase activity
MF133_21215	COG1846	Transcriptional regulator
MF133_21220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MF133_21225	COG0363	glucosamine-6-phosphate deaminase activity
MF133_21230	COG2190	(PTS) system
MF133_21230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF133_21230	COG1263	PTS System
MF133_21245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF133_21250	COG0735	belongs to the Fur family
MF133_21260	COG0716	FMN binding
MF133_21275	COG0596	Alpha beta hydrolase
MF133_21280	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MF133_21285	COG0033	Phosphoglucomutase
MF133_21295	COG1846	Transcriptional regulator
MF133_21300	COG2951	lytic endotransglycosylase activity
MF133_21305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MF133_21310	COG4136	ATPase activity
MF133_21320	COG4134	Bacterial extracellular solute-binding protein
MF133_21325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF133_21330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MF133_21340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF133_21350	COG0729	surface antigen
MF133_21355	COG2911	Protein conserved in bacteria
MF133_21375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MF133_21385	COG0741	lytic transglycosylase activity
MF133_21400	COG1607	acyl-coa hydrolase
MF133_21415	COG1388	LysM domain
MF133_21415	COG0741	lytic transglycosylase activity
MF133_21425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MF133_21430	COG2226	methyltransferase
MF133_21435	COG0328	RNA-DNA hybrid ribonuclease activity
MF133_21440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MF133_21450	COG0784	Response regulator, receiver
MF133_21450	COG3437	response regulator, receiver
MF133_21455	COG1960	acyl-CoA dehydrogenase activity
MF133_21460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MF133_21465	COG0121	glutamine amidotransferase
MF133_21475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MF133_21505	COG2197	response regulator
MF133_21510	COG3850	Histidine kinase
MF133_21515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MF133_21520	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
MF133_21520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MF133_21530	COG0243	molybdopterin cofactor binding
MF133_21535	COG0437	4 iron, 4 sulfur cluster binding
MF133_21540	COG0348	domain, Protein
MF133_21550	COG3005	denitrification pathway
MF133_21555	COG0521	Mo-molybdopterin cofactor biosynthetic process
MF133_21560	COG0315	cyclic pyranopterin monophosphate synthase activity
MF133_21565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MF133_21570	COG0314	molybdopterin synthase activity
MF133_21585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MF133_21590	COG2267	carboxylic ester hydrolase activity
MF133_21605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MF133_21615	COG0302	gtp cyclohydrolase
MF133_21625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MF133_21635	COG0583	DNA-binding transcription factor activity
MF133_21650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MF133_21665	COG2195	Cleaves the N-terminal amino acid of tripeptides
MF133_21670	COG1166	arginine decarboxylase activity
MF133_21695	COG1403	HNH endonuclease
MF133_21710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MF133_21715	COG1187	pseudouridine synthase activity
MF133_21720	COG2807	transmembrane transport
MF133_21730	COG0583	DNA-binding transcription factor activity
MF133_21750	COG2979	Protein of unknown function (DUF533)
MF133_21760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF133_21765	COG1271	oxidase subunit
MF133_21770	COG1294	oxidase, subunit
MF133_21780	COG2814	Major facilitator Superfamily
MF133_21785	COG0656	L-ascorbic acid biosynthetic process
MF133_21805	COG0583	DNA-binding transcription factor activity
MF133_21810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MF133_21815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MF133_21820	COG2271	Major facilitator Superfamily
MF133_21835	COG0584	glycerophosphoryl diester phosphodiesterase
MF133_21840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF133_21845	COG1605	Chorismate mutase
MF133_21845	COG0287	Prephenate dehydrogenase
MF133_21855	COG3085	chromosome segregation
MF133_21860	COG4574	serine-type endopeptidase inhibitor activity
MF133_21880	COG1770	oligopeptidase
MF133_21885	COG4771	TonB-dependent receptor
MF133_21890	COG3083	sulfuric ester hydrolase activity
MF133_21895	COG3082	Protein of unknown function (DUF1414)
MF133_21900	COG3081	Nucleoid-associated protein
MF133_21910	COG1175	transmembrane transport
MF133_21915	COG3833	ABC-type maltose transport systems, permease component
MF133_21920	COG3842	ATPase activity
MF133_21945	COG0425	Belongs to the sulfur carrier protein TusA family
MF133_21950	COG4783	chaperone-mediated protein folding
MF133_21960	COG1393	Belongs to the ArsC family
MF133_21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_21990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MF133_21995	COG2431	L-lysine efflux transmembrane transporter activity
MF133_22005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF133_22015	COG4160	amino acid transport
MF133_22025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MF133_22035	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF133_22060	COG0628	permease
MF133_22065	COG2373	Large extracellular alpha-helical protein
MF133_22070	COG4953	penicillin-binding protein 1C
MF133_22080	COG0301	tRNA thio-modification
MF133_22080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MF133_22095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF133_22100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF133_22140	COG2089	acid synthase
MF133_22155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MF133_22160	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MF133_22170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MF133_22175	COG1086	Polysaccharide biosynthesis protein
MF133_22180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MF133_22190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MF133_22210	COG0346	lactoylglutathione lyase activity
MF133_22215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MF133_22220	COG4660	Part of a membrane complex involved in electron transport
MF133_22225	COG4659	FMN binding
MF133_22230	COG4658	electron transport chain
MF133_22240	COG2878	Part of a membrane complex involved in electron transport
MF133_22245	COG4657	Part of a membrane complex involved in electron transport
MF133_22250	COG0697	spore germination
MF133_22275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MF133_22280	COG1288	antiporter activity
MF133_22285	COG0436	Aminotransferase
MF133_22295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MF133_22300	COG2027	D-alanyl-D-alanine carboxypeptidase
MF133_22305	COG1061	Type III restriction enzyme res subunit
MF133_22310	COG1566	PFAM secretion protein HlyD family protein
MF133_22320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MF133_22320	COG3264	Mechanosensitive ion channel
MF133_22325	COG1966	Carbon starvation protein
MF133_22330	COG3279	Response regulator of the LytR AlgR family
MF133_22335	COG3275	phosphorelay sensor kinase activity
MF133_22345	COG1012	belongs to the aldehyde dehydrogenase family
MF133_22345	COG1454	alcohol dehydrogenase
MF133_22360	COG0601	transmembrane transport
MF133_22365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF133_22370	COG0444	Belongs to the ABC transporter superfamily
MF133_22380	COG0861	Integral membrane protein TerC family
MF133_22385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MF133_22395	COG1301	dicarboxylic acid transport
MF133_22410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MF133_22425	COG0537	adenosine 5'-monophosphoramidase activity
MF133_22460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF133_22465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF133_22480	COG2354	Protein conserved in bacteria
MF133_22485	COG1164	Oligoendopeptidase f
MF133_22490	COG1164	Oligoendopeptidase f
MF133_22495	COG3150	esterase
MF133_22500	COG1252	NADH dehydrogenase
MF133_22505	COG0393	Putative heavy-metal-binding
MF133_22510	COG1368	sulfuric ester hydrolase activity
MF133_22520	COG0527	aspartate kinase activity
MF133_22525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MF133_22525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MF133_22530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MF133_22555	COG0583	DNA-binding transcription factor activity
MF133_22560	COG1620	l-lactate permease
MF133_22565	COG0247	lactate metabolic process
MF133_22570	COG1139	Iron-sulfur cluster binding protein
MF133_22620	COG1136	(ABC) transporter
MF133_22640	COG2814	Major facilitator Superfamily
MF133_22685	COG0672	)-iron permease
MF133_22730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MF133_22730	COG2308	Evidence 4 Homologs of previously reported genes of