locus-tag	class	description
LEO80_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEO80_00010	COG0592	DNA-directed DNA polymerase activity
LEO80_00020	COG0187	DNA topoisomerase II activity
LEO80_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO80_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO80_00055	COG3977	Valine--pyruvate aminotransferase
LEO80_00070	COG2814	Major facilitator Superfamily
LEO80_00075	COG0745	RESPONSE REGULATOR receiver
LEO80_00080	COG2205	protein histidine kinase activity
LEO80_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO80_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_00105	COG4191	Histidine kinase
LEO80_00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_00120	COG1309	transcriptional regulator
LEO80_00150	COG0561	phosphatase activity
LEO80_00155	COG2267	carboxylic ester hydrolase activity
LEO80_00160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO80_00165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO80_00170	COG1758	RNA polymerase activity
LEO80_00180	COG0859	PFAM glycosyl transferase family 9
LEO80_00185	COG3642	lipopolysaccharide core region biosynthetic process
LEO80_00225	COG0589	response to stress
LEO80_00230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO80_00235	COG3706	GGDEF domain
LEO80_00240	COG1528	Iron-storage protein
LEO80_00245	COG2081	HI0933 family
LEO80_00250	COG2223	nitrite transmembrane transporter activity
LEO80_00255	COG1280	lysine exporter protein (LysE YggA)
LEO80_00280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEO80_00285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEO80_00300	COG0583	DNA-binding transcription factor activity
LEO80_00345	COG1042	CoA-binding domain protein
LEO80_00345	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO80_00345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO80_00355	COG0583	DNA-binding transcription factor activity
LEO80_00360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEO80_00365	COG0166	Belongs to the GPI family
LEO80_00375	COG0668	transmembrane transport
LEO80_00395	COG1309	transcriptional regulator
LEO80_00400	COG0756	dUTP diphosphatase activity
LEO80_00405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEO80_00410	COG2003	Belongs to the UPF0758 family
LEO80_00415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEO80_00420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEO80_00430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEO80_00435	COG2990	Protein conserved in bacteria
LEO80_00440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEO80_00445	COG0859	PFAM glycosyl transferase family 9
LEO80_00450	COG0463	Glycosyl transferase, family 2
LEO80_00455	COG0859	PFAM glycosyl transferase family 9
LEO80_00460	COG1519	Transferase
LEO80_00470	COG1561	YicC-like family, N-terminal region
LEO80_00475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEO80_00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEO80_00495	COG5001	Diguanylate cyclase
LEO80_00495	COG2203	Gaf domain
LEO80_00495	COG3706	GGDEF domain
LEO80_00495	COG4251	negative regulation of phosphorylation
LEO80_00500	COG3084	Protein conserved in bacteria
LEO80_00510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEO80_00515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO80_00520	COG3639	organic phosphonate transmembrane transporter activity
LEO80_00525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LEO80_00530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LEO80_00540	COG1335	isochorismatase
LEO80_00550	COG1683	Conserved Protein
LEO80_00555	COG0204	Acyl-transferase
LEO80_00560	COG0204	Acyl-transferase
LEO80_00565	COG0606	chelatase, subunit chli
LEO80_00575	COG3978	acetolactate synthase activity
LEO80_00585	COG0129	dihydroxy-acid dehydratase activity
LEO80_00605	COG1309	transcriptional regulator
LEO80_00610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEO80_00615	COG0254	rRNA binding
LEO80_00620	COG0702	epimerase
LEO80_00625	COG0281	malic enzyme
LEO80_00635	COG2205	protein histidine kinase activity
LEO80_00650	COG0745	RESPONSE REGULATOR receiver
LEO80_00655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO80_00670	COG0366	Alpha amylase catalytic
LEO80_00685	COG0443	Heat shock 70 kDa protein
LEO80_00690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO80_00695	COG3045	CreA protein
LEO80_00715	COG0174	glutamine synthetase
LEO80_00735	COG3842	ATPase activity
LEO80_00740	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO80_00745	COG1177	transmembrane transport
LEO80_00750	COG2258	MOSC domain
LEO80_00765	COG2050	protein possibly involved in aromatic compounds catabolism
LEO80_00770	COG0514	ATP-dependent DNA helicase (RecQ)
LEO80_00780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEO80_00790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEO80_00795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO80_00800	COG2239	Acts as a magnesium transporter
LEO80_00805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO80_00805	COG1648	precorrin-2 dehydrogenase activity
LEO80_00810	COG2116	formate transmembrane transporter activity
LEO80_00820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO80_00825	COG0842	Transport permease protein
LEO80_00830	COG0842	Transport permease protein
LEO80_00835	COG1131	(ABC) transporter
LEO80_00840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_00855	COG0477	Major facilitator Superfamily
LEO80_00860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LEO80_00865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LEO80_00885	COG1595	DNA-templated transcription, initiation
LEO80_00890	COG3806	Anti-sigma factor
LEO80_00895	COG1968	undecaprenyl-diphosphatase activity
LEO80_00900	COG0667	Aldo Keto reductase
LEO80_00905	COG2017	converts alpha-aldose to the beta-anomer
LEO80_00910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO80_00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO80_00925	COG1609	Transcriptional regulator
LEO80_00930	COG3250	beta-galactosidase activity
LEO80_00975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO80_00980	COG1288	antiporter activity
LEO80_00985	COG1438	arginine binding
LEO80_00990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEO80_00995	COG0540	Belongs to the ATCase OTCase family
LEO80_01015	COG0583	DNA-binding transcription factor activity
LEO80_01035	COG3040	lipid binding
LEO80_01040	COG2207	Transcriptional regulator
LEO80_01045	COG1979	alcohol dehydrogenase
LEO80_01050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEO80_01055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEO80_01060	COG2964	Protein conserved in bacteria
LEO80_01065	COG3681	Belongs to the UPF0597 family
LEO80_01070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO80_01075	COG0564	pseudouridine synthase activity
LEO80_01085	COG0542	response to heat
LEO80_01090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO80_01095	COG2502	aspartate--ammonia ligase
LEO80_01100	COG1522	sequence-specific DNA binding
LEO80_01110	COG0517	IMP dehydrogenase activity
LEO80_01110	COG0516	GMP reductase activity
LEO80_01130	COG2205	protein histidine kinase activity
LEO80_01140	COG2204	response regulator
LEO80_01150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LEO80_01185	COG0243	molybdopterin cofactor binding
LEO80_01190	COG3005	denitrification pathway
LEO80_01195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEO80_01200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO80_01205	COG0569	domain protein
LEO80_01210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEO80_01235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO80_01250	COG0250	Participates in transcription elongation, termination and antitermination
LEO80_01255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEO80_01260	COG0081	regulation of translation
LEO80_01265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEO80_01270	COG0222	ribosome binding
LEO80_01275	COG0085	RNA polymerase activity
LEO80_01280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEO80_01285	COG3385	transposase activity
LEO80_01290	COG2964	Protein conserved in bacteria
LEO80_01295	COG0251	oxidation-reduction process
LEO80_01300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO80_01310	COG2168	tRNA wobble position uridine thiolation
LEO80_01315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEO80_01320	COG0049	tRNA binding
LEO80_01325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEO80_01330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO80_01335	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO80_01375	COG1484	DNA-dependent DNA replication
LEO80_01380	COG4584	PFAM Integrase catalytic
LEO80_01395	COG2252	PERMEase
LEO80_01400	COG2376	Dihydroxyacetone kinase
LEO80_01405	COG1461	Dihydroxyacetone kinase
LEO80_01420	COG0583	DNA-binding transcription factor activity
LEO80_01425	COG2957	Belongs to the agmatine deiminase family
LEO80_01440	COG2957	Belongs to the agmatine deiminase family
LEO80_01450	COG0628	permease
LEO80_01455	COG0494	nUDIX hydrolase
LEO80_01475	COG0753	catalase activity
LEO80_01480	COG0456	acetyltransferase
LEO80_01510	COG3842	ATPase activity
LEO80_01520	COG1175	transmembrane transport
LEO80_01545	COG0583	DNA-binding transcription factor activity
LEO80_01555	COG1741	Belongs to the pirin family
LEO80_01560	COG2259	Doxx family
LEO80_01565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LEO80_01570	COG1074	ATP-dependent DNA helicase activity
LEO80_01575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO80_01590	COG0346	lactoylglutathione lyase activity
LEO80_01600	COG0004	ammonium transporteR
LEO80_01605	COG0347	Belongs to the P(II) protein family
LEO80_01610	COG3706	GGDEF domain
LEO80_01640	COG1278	Cold shock
LEO80_01660	COG2197	response regulator
LEO80_01665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEO80_01670	COG3047	cAMP biosynthetic process
LEO80_01700	COG3135	benzoate transporter
LEO80_01705	COG1396	sequence-specific DNA binding
LEO80_01735	COG2926	Belongs to the UPF0265 family
LEO80_01745	COG3028	Belongs to the UPF0307 family
LEO80_01750	COG0312	modulator of DNA gyrase
LEO80_01760	COG3071	HemY protein
LEO80_01765	COG2959	enzyme of heme biosynthesis
LEO80_01775	COG0181	hydroxymethylbilane synthase activity
LEO80_01780	COG3072	Adenylate cyclase
LEO80_01785	COG0400	carboxylic ester hydrolase activity
LEO80_01790	COG1965	Belongs to the frataxin family
LEO80_01800	COG0019	diaminopimelate decarboxylase activity
LEO80_01805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEO80_01820	COG1011	Hydrolase
LEO80_01830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO80_01835	COG0561	phosphatase activity
LEO80_01845	COG1988	membrane-bound metal-dependent
LEO80_01850	COG1058	Belongs to the CinA family
LEO80_01850	COG1546	Belongs to the CinA family
LEO80_01860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEO80_01870	COG1522	sequence-specific DNA binding
LEO80_01875	COG1368	sulfuric ester hydrolase activity
LEO80_01890	COG1285	pathogenesis
LEO80_01910	COG4221	oxidoreductase activity
LEO80_01925	COG1979	alcohol dehydrogenase
LEO80_01935	COG2873	o-acetylhomoserine
LEO80_01945	COG4533	DNA binding
LEO80_01965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO80_01975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEO80_01980	COG2949	membrane
LEO80_01985	COG3291	Pkd domain containing protein
LEO80_01990	COG0318	PFAM AMP-dependent synthetase and ligase
LEO80_02000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEO80_02005	COG0596	Alpha beta hydrolase
LEO80_02010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEO80_02015	COG1169	isochorismate synthase
LEO80_02020	COG1575	Belongs to the MenA family. Type 1 subfamily
LEO80_02040	COG0513	Belongs to the DEAD box helicase family
LEO80_02045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO80_02060	COG1671	Belongs to the UPF0178 family
LEO80_02085	COG3722	fumarate hydratase activity
LEO80_02090	COG0246	Mannitol dehydrogenase
LEO80_02095	COG2213	PTS system mannitol-specific
LEO80_02095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_02100	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LEO80_02110	COG3916	Acyl-homoserine-lactone synthase
LEO80_02115	COG2771	luxR family
LEO80_02130	COG1560	Kdo2-lipid A biosynthetic process
LEO80_02135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEO80_02135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEO80_02140	COG1538	Outer membrane efflux protein
LEO80_02145	COG0494	nUDIX hydrolase
LEO80_02150	COG3151	Protein conserved in bacteria
LEO80_02160	COG3150	esterase
LEO80_02165	COG1051	belongs to the nudix hydrolase family
LEO80_02180	COG1566	PFAM secretion protein HlyD family protein
LEO80_02185	COG1289	transmembrane transporter activity
LEO80_02205	COG3039	Transposase
LEO80_02245	COG2894	cell division
LEO80_02255	COG1215	transferase activity, transferring glycosyl groups
LEO80_02260	COG0457	Tetratricopeptide repeat
LEO80_02275	COG2194	sulfuric ester hydrolase activity
LEO80_02290	COG3385	transposase activity
LEO80_02330	COG0484	heat shock protein binding
LEO80_02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO80_02360	COG0204	Acyl-transferase
LEO80_02365	COG1842	Phage shock protein A
LEO80_02380	COG2827	Endonuclease containing a URI domain
LEO80_02385	COG2962	Rard protein
LEO80_02390	COG1573	uracil-dna glycosylase
LEO80_02400	COG0583	DNA-binding transcription factor activity
LEO80_02405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEO80_02410	COG1121	(ABC) transporter
LEO80_02415	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LEO80_02435	COG0739	heme binding
LEO80_02445	COG3068	Protein conserved in bacteria
LEO80_02475	COG1522	sequence-specific DNA binding
LEO80_02480	COG0110	maltose O-acetyltransferase activity
LEO80_02485	COG0366	Alpha amylase catalytic
LEO80_02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO80_02490	COG1263	PTS System
LEO80_02510	COG0252	asparaginase activity
LEO80_02525	COG1803	Methylglyoxal synthase
LEO80_02545	COG1444	tRNA N-acetyltransferase activity
LEO80_02550	COG1565	acr, cog1565
LEO80_02550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO80_02560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LEO80_02590	COG0109	protoheme IX farnesyltransferase activity
LEO80_02595	COG1012	belongs to the aldehyde dehydrogenase family
LEO80_02600	COG1177	transmembrane transport
LEO80_02605	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO80_02610	COG3842	ATPase activity
LEO80_02615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEO80_02620	COG0583	DNA-binding transcription factor activity
LEO80_02625	COG1757	Na H antiporter
LEO80_02665	COG0297	glycogen (starch) synthase activity
LEO80_02670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO80_02675	COG2813	Specifically methylates the guanine in position
LEO80_02680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO80_02685	COG2203	Gaf domain
LEO80_02685	COG4251	negative regulation of phosphorylation
LEO80_02685	COG3706	GGDEF domain
LEO80_02685	COG5001	Diguanylate cyclase
LEO80_02690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO80_02700	COG2995	paraquat-inducible protein a
LEO80_02705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO80_02705	COG3008	intermembrane lipid transfer
LEO80_02710	COG3009	Protein conserved in bacteria
LEO80_02720	COG3240	lipase activity
LEO80_02735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LEO80_02740	COG1194	a g-specific adenine glycosylase
LEO80_02750	COG3267	Type II secretory pathway component ExeA
LEO80_02750	COG3409	Peptidoglycan-binding domain 1 protein
LEO80_02755	COG0617	tRNA 3'-terminal CCA addition
LEO80_02760	COG0306	phosphate transporter
LEO80_02765	COG1392	Phosphate transport regulator
LEO80_02770	COG3025	triphosphatase activity
LEO80_02775	COG3133	Outer membrane lipoprotein
LEO80_02780	COG0456	acetyltransferase
LEO80_02795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEO80_02800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEO80_02810	COG3031	protein transport across the cell outer membrane
LEO80_02820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO80_02825	COG1459	type II secretion system
LEO80_02830	COG2165	general secretion pathway protein
LEO80_02840	COG2165	general secretion pathway protein
LEO80_02845	COG4795	General secretion pathway protein
LEO80_02850	COG3156	type II secretion system protein K
LEO80_02860	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LEO80_02875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO80_02885	COG1902	pentaerythritol trinitrate reductase activity
LEO80_02890	COG1011	Hydrolase
LEO80_02895	COG0494	nUDIX hydrolase
LEO80_02900	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO80_02905	COG0814	amino acid
LEO80_02910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO80_02925	COG0626	cystathionine gamma-synthase activity
LEO80_02930	COG0460	homoserine dehydrogenase
LEO80_02930	COG0527	aspartate kinase activity
LEO80_02935	COG1346	cytolysis
LEO80_02940	COG1380	Effector of murein hydrolase LrgA
LEO80_02945	COG0583	DNA-binding transcription factor activity
LEO80_02980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEO80_02990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEO80_03000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEO80_03005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO80_03015	COG0137	argininosuccinate synthase activity
LEO80_03020	COG0165	Argininosuccinate lyase
LEO80_03025	COG0583	DNA-binding transcription factor activity
LEO80_03035	COG1942	4-Oxalocrotonate Tautomerase
LEO80_03065	COG0110	maltose O-acetyltransferase activity
LEO80_03070	COG3174	membrane
LEO80_03075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_03080	COG1126	abc transporter atp-binding protein
LEO80_03085	COG0765	amino acid transport
LEO80_03090	COG0765	amino acid transport
LEO80_03095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO80_03100	COG1505	serine-type exopeptidase activity
LEO80_03110	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_03115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LEO80_03130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO80_03135	COG4991	sh3 domain protein
LEO80_03145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEO80_03150	COG1940	carbohydrate kinase activity
LEO80_03155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO80_03160	COG0126	phosphoglycerate kinase activity
LEO80_03170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO80_03200	COG0583	DNA-binding transcription factor activity
LEO80_03205	COG0354	folic acid binding
LEO80_03210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LEO80_03220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEO80_03225	COG1595	DNA-templated transcription, initiation
LEO80_03230	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LEO80_03245	COG0481	GTPase activity
LEO80_03250	COG0681	Belongs to the peptidase S26 family
LEO80_03255	COG0571	ribonuclease III activity
LEO80_03265	COG1381	Involved in DNA repair and RecF pathway recombination
LEO80_03270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEO80_03275	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEO80_03280	COG4807	Protein conserved in bacteria
LEO80_03290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO80_03295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO80_03300	COG3956	TIGRFAM MazG family protein
LEO80_03305	COG0504	CTP synthase activity
LEO80_03310	COG0148	phosphopyruvate hydratase activity
LEO80_03315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LEO80_03320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEO80_03325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LEO80_03330	COG0585	pseudouridine synthase activity
LEO80_03335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEO80_03340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO80_03345	COG1238	metal cluster binding
LEO80_03350	COG1388	LysM domain
LEO80_03350	COG4942	peptidase
LEO80_03360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEO80_03365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEO80_03370	COG1610	YqeY-like protein
LEO80_03375	COG0358	DNA primase activity
LEO80_03380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO80_03415	COG0151	Belongs to the GarS family
LEO80_03420	COG0138	bifunctional purine biosynthesis protein purh
LEO80_03435	COG3036	rescue of stalled ribosome
LEO80_03440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO80_03445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEO80_03455	COG0673	inositol 2-dehydrogenase activity
LEO80_03465	COG1585	Membrane protein implicated in regulation of membrane protease activity
LEO80_03470	COG0330	HflC and HflK could
LEO80_03475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO80_03475	COG1648	precorrin-2 dehydrogenase activity
LEO80_03480	COG0175	sulfate reduction
LEO80_03485	COG2895	sulfate adenylyltransferase (ATP) activity
LEO80_03490	COG3273	potassium ion transport
LEO80_03490	COG0471	metal ion transport
LEO80_03495	COG0529	Catalyzes the synthesis of activated sulfate
LEO80_03515	COG5433	transposase activity
LEO80_03560	COG1136	(ABC) transporter
LEO80_03575	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LEO80_03605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEO80_03610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO80_03615	COG0163	prenyltransferase activity
LEO80_03630	COG1131	(ABC) transporter
LEO80_03635	COG0842	Transport permease protein
LEO80_03645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEO80_03650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEO80_03655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEO80_03665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO80_03670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LEO80_03675	COG1489	DNA binding
LEO80_03685	COG1643	Atp-dependent helicase
LEO80_03690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO80_03695	COG0346	lactoylglutathione lyase activity
LEO80_03705	COG2076	Multidrug Resistance protein
LEO80_03710	COG0583	DNA-binding transcription factor activity
LEO80_03720	COG0671	phosphoesterase, PA-phosphatase related
LEO80_03735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEO80_03740	COG0038	chloride channel
LEO80_03750	COG0316	Belongs to the HesB IscA family
LEO80_03775	COG1280	lysine exporter protein (LysE YggA)
LEO80_03790	COG1074	ATP-dependent DNA helicase activity
LEO80_03810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO80_03880	COG2003	Belongs to the UPF0758 family
LEO80_03925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO80_03940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LEO80_03950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LEO80_03965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_03995	COG0745	RESPONSE REGULATOR receiver
LEO80_04000	COG3104	oligopeptide transport
LEO80_04005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEO80_04010	COG1555	photosystem II stabilization
LEO80_04020	COG2350	Protein conserved in bacteria
LEO80_04025	COG2917	probably involved in intracellular septation
LEO80_04030	COG0076	glutamate decarboxylase activity
LEO80_04035	COG1272	protein, Hemolysin III
LEO80_04040	COG0569	domain protein
LEO80_04040	COG2985	domain, Protein
LEO80_04050	COG0477	Major facilitator Superfamily
LEO80_04055	COG0583	DNA-binding transcription factor activity
LEO80_04060	COG3227	Zinc metalloprotease (Elastase)
LEO80_04065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO80_04070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO80_04080	COG2731	YhcH YjgK YiaL family protein
LEO80_04090	COG0668	transmembrane transport
LEO80_04100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO80_04110	COG0789	Transcriptional regulator
LEO80_04160	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LEO80_04170	COG0488	(ABC) transporter
LEO80_04175	COG0516	GMP reductase activity
LEO80_04175	COG0517	IMP dehydrogenase activity
LEO80_04185	COG0835	chemotaxis
LEO80_04185	COG0784	Response regulator, receiver
LEO80_04190	COG2755	lipolytic protein G-D-S-L family
LEO80_04195	COG4181	ATPase activity
LEO80_04200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LEO80_04205	COG1090	epimerase
LEO80_04210	COG2200	EAL domain
LEO80_04215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO80_04220	COG2234	aminopeptidase activity
LEO80_04220	COG4935	Belongs to the peptidase S8 family
LEO80_04225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEO80_04230	COG3171	Protein conserved in bacteria
LEO80_04235	COG2066	Belongs to the glutaminase family
LEO80_04240	COG2897	thiosulfate sulfurtransferase activity
LEO80_04250	COG1132	(ABC) transporter
LEO80_04275	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LEO80_04285	COG3300	MHYT domain
LEO80_04285	COG5001	Diguanylate cyclase
LEO80_04295	COG2207	Transcriptional regulator
LEO80_04300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO80_04315	COG4628	conserved protein (DUF2132)
LEO80_04320	COG0688	phosphatidylethanolamine metabolic process
LEO80_04330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LEO80_04370	COG1278	Cold shock
LEO80_04380	COG0840	transmembrane signaling receptor activity
LEO80_04385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO80_04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO80_04440	COG0848	biopolymer transport protein
LEO80_04445	COG0811	peptide transport
LEO80_04450	COG0811	peptide transport
LEO80_04460	COG4206	TonB-dependent receptor
LEO80_04465	COG4174	ABC transporter (Permease)
LEO80_04470	COG4239	(ABC) transporter, permease
LEO80_04480	COG0444	Belongs to the ABC transporter superfamily
LEO80_04485	COG4608	Belongs to the ABC transporter superfamily
LEO80_04490	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO80_04495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LEO80_04500	COG1073	alpha beta
LEO80_04515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEO80_04545	COG0243	molybdopterin cofactor binding
LEO80_04550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO80_04550	COG1648	precorrin-2 dehydrogenase activity
LEO80_04560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEO80_04560	COG1116	anion transmembrane transporter activity
LEO80_04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEO80_04570	COG1116	anion transmembrane transporter activity
LEO80_04575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO80_04575	COG2146	nitrite reductase [NAD(P)H] activity
LEO80_04580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO80_04580	COG2146	nitrite reductase [NAD(P)H] activity
LEO80_04585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO80_04590	COG2313	pseudouridylate synthase activity
LEO80_04610	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO80_04625	COG2966	Psort location CytoplasmicMembrane, score
LEO80_04630	COG3610	response to peptide
LEO80_04640	COG4175	Glycine betaine
LEO80_04645	COG4176	ABC-type proline glycine betaine transport system permease component
LEO80_04650	COG2113	Glycine betaine
LEO80_04655	COG0175	sulfate reduction
LEO80_04660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO80_04665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO80_04670	COG0384	phenazine biosynthesis protein PhzF
LEO80_04675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEO80_04690	COG0786	glutamate:sodium symporter activity
LEO80_04695	COG0252	asparaginase activity
LEO80_04700	COG3139	Protein of unknown function (DUF1315)
LEO80_04720	COG0616	signal peptide processing
LEO80_04725	COG1902	pentaerythritol trinitrate reductase activity
LEO80_04725	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO80_04730	COG0778	Nitroreductase
LEO80_04745	COG0110	maltose O-acetyltransferase activity
LEO80_04750	COG2264	protein methyltransferase activity
LEO80_04755	COG0604	alcohol dehydrogenase
LEO80_04760	COG0583	DNA-binding transcription factor activity
LEO80_04765	COG2190	(PTS) system
LEO80_04765	COG1263	PTS System
LEO80_04765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO80_04770	COG4145	pantothenate transmembrane transporter activity
LEO80_04775	COG3924	membrane
LEO80_04780	COG0439	Biotin carboxylase
LEO80_04785	COG0511	ligase activity, forming carbon-carbon bonds
LEO80_04790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEO80_04795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO80_04810	COG3381	protein complex oligomerization
LEO80_04820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEO80_04830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEO80_04835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO80_04835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO80_04850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEO80_04855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO80_04860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEO80_04865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LEO80_04870	COG4172	Belongs to the ABC transporter superfamily
LEO80_04880	COG0601	transmembrane transport
LEO80_04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO80_04890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEO80_04895	COG0142	geranyltranstransferase activity
LEO80_04900	COG1722	exodeoxyribonuclease VII activity
LEO80_04905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO80_04910	COG1360	Flagellar Motor Protein
LEO80_04925	COG1534	Rna-binding protein
LEO80_04930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LEO80_04940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEO80_04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO80_04950	COG0149	triose-phosphate isomerase activity
LEO80_04955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEO80_04970	COG0779	Required for maturation of 30S ribosomal subunits
LEO80_04975	COG0195	Participates in both transcription termination and antitermination
LEO80_04980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEO80_04985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEO80_04990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEO80_04995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEO80_05000	COG1185	polyribonucleotide nucleotidyltransferase activity
LEO80_05010	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO80_05015	COG1422	Protein of unknown function (DUF1090)
LEO80_05020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO80_05025	COG0826	peptidase U32
LEO80_05040	COG0312	modulator of DNA gyrase
LEO80_05045	COG0312	modulator of DNA gyrase
LEO80_05055	COG4974	Belongs to the 'phage' integrase family
LEO80_05060	COG1970	mechanosensitive ion channel activity
LEO80_05075	COG0789	Transcriptional regulator
LEO80_05095	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO80_05105	COG3385	transposase activity
LEO80_05110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEO80_05115	COG0321	lipoyl(octanoyl) transferase activity
LEO80_05120	COG2921	Belongs to the UPF0250 family
LEO80_05125	COG1686	Belongs to the peptidase S11 family
LEO80_05130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO80_05135	COG2951	lytic endotransglycosylase activity
LEO80_05140	COG0772	Belongs to the SEDS family
LEO80_05145	COG0768	penicillin binding
LEO80_05150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEO80_05155	COG0799	negative regulation of ribosome biogenesis
LEO80_05160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEO80_05175	COG0495	leucyl-tRNA aminoacylation
LEO80_05180	COG2888	peptidyl-tyrosine sulfation
LEO80_05185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO80_05190	COG4535	Mg2 and Co2 transporter CorC
LEO80_05195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEO80_05200	COG1702	phosphate starvation-inducible protein PhoH
LEO80_05205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO80_05210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO80_05215	COG1335	isochorismatase
LEO80_05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO80_05235	COG2199	diguanylate cyclase activity
LEO80_05245	COG2199	diguanylate cyclase activity
LEO80_05255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO80_05270	COG1464	Belongs to the NlpA lipoprotein family
LEO80_05280	COG2011	ABC-type metal ion transport system permease component
LEO80_05285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEO80_05295	COG0516	GMP reductase activity
LEO80_05300	COG0189	ligase activity
LEO80_05300	COG4067	protein conserved in archaea
LEO80_05320	COG0300	oxidoreductase activity
LEO80_05340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO80_05345	COG3214	Protein conserved in bacteria
LEO80_05360	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO80_05365	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO80_05370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEO80_05375	COG1053	succinate dehydrogenase
LEO80_05385	COG0584	glycerophosphoryl diester phosphodiesterase
LEO80_05390	COG3264	Mechanosensitive ion channel
LEO80_05390	COG1511	domain protein
LEO80_05400	COG0739	heme binding
LEO80_05420	COG0583	DNA-binding transcription factor activity
LEO80_05435	COG0583	DNA-binding transcription factor activity
LEO80_05440	COG3385	transposase activity
LEO80_05445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEO80_05475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEO80_05480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEO80_05490	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LEO80_05495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEO80_05500	COG0546	phosphoglycolate phosphatase activity
LEO80_05505	COG0180	Tryptophanyl-tRNA synthetase
LEO80_05520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEO80_05530	COG1012	belongs to the aldehyde dehydrogenase family
LEO80_05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO80_05560	COG0657	acetylesterase activity
LEO80_05570	COG0490	domain, Protein
LEO80_05570	COG0471	metal ion transport
LEO80_05615	COG0012	GTP binding
LEO80_05620	COG0193	aminoacyl-tRNA hydrolase activity
LEO80_05625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEO80_05635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEO80_05640	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LEO80_05645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEO80_05650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEO80_05655	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO80_05665	COG2912	Transglutaminase-like superfamily
LEO80_05670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEO80_05675	COG1301	dicarboxylic acid transport
LEO80_05685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEO80_05700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO80_05705	COG1115	amino acid carrier protein
LEO80_05725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEO80_05735	COG0189	ligase activity
LEO80_05740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEO80_05750	COG3091	SprT-like family
LEO80_05760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEO80_05805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEO80_05810	COG0739	heme binding
LEO80_05815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO80_05825	COG1881	PFAM PEBP family protein
LEO80_05830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEO80_05835	COG0583	DNA-binding transcription factor activity
LEO80_05845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO80_05855	COG0583	DNA-binding transcription factor activity
LEO80_05860	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_05865	COG0616	signal peptide processing
LEO80_05870	COG3724	N-succinylarginine dihydrolase activity
LEO80_05890	COG0840	transmembrane signaling receptor activity
LEO80_05900	COG2971	BadF BadG BcrA BcrD
LEO80_05910	COG4608	Belongs to the ABC transporter superfamily
LEO80_05915	COG0444	Belongs to the ABC transporter superfamily
LEO80_05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO80_05935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO80_05950	COG0640	Transcriptional regulator
LEO80_05955	COG0798	PFAM Bile acid sodium symporter
LEO80_05960	COG1393	Belongs to the ArsC family
LEO80_05970	COG1677	Flagellar hook-basal body complex protein FliE
LEO80_05980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEO80_06035	COG1684	flagellar biosynthetic protein fliR
LEO80_06070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LEO80_06075	COG0643	Histidine kinase
LEO80_06075	COG0784	Response regulator, receiver
LEO80_06075	COG2198	Histidine kinase
LEO80_06085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO80_06090	COG1360	Flagellar Motor Protein
LEO80_06095	COG1192	Involved in chromosome partitioning
LEO80_06105	COG0835	chemotaxis
LEO80_06120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO80_06125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO80_06130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO80_06135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEO80_06140	COG1138	Cytochrome C-type biogenesis protein
LEO80_06145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO80_06155	COG0457	Tetratricopeptide repeat
LEO80_06170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEO80_06175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO80_06175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO80_06190	COG0259	pyridoxamine-phosphate oxidase activity
LEO80_06220	COG3153	acetyltransferase
LEO80_06235	COG0800	Aldolase
LEO80_06240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO80_06250	COG2721	sulfolactate sulfo-lyase activity
LEO80_06255	COG0246	Mannitol dehydrogenase
LEO80_06290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEO80_06295	COG2867	negative regulation of translational initiation
LEO80_06300	COG2914	Belongs to the UPF0125 (RnfH) family
LEO80_06305	COG0702	epimerase
LEO80_06310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO80_06315	COG1454	alcohol dehydrogenase
LEO80_06330	COG1957	nucleoside hydrolase
LEO80_06355	COG1280	lysine exporter protein (LysE YggA)
LEO80_06365	COG3263	regulation of cellular component size
LEO80_06375	COG1876	peptidase activity
LEO80_06380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO80_06385	COG1393	Belongs to the ArsC family
LEO80_06395	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO80_06400	COG1473	amidohydrolase
LEO80_06410	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO80_06415	COG0017	Asparaginyl-tRNA synthetase
LEO80_06435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO80_06440	COG0156	8-amino-7-oxononanoate synthase activity
LEO80_06450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEO80_06455	COG0501	Belongs to the peptidase M48B family
LEO80_06460	COG0633	Ferredoxin
LEO80_06460	COG3217	Mosc domain protein beta barrel domain protein
LEO80_06460	COG0633	Ferredoxin
LEO80_06460	COG3217	Mosc domain protein beta barrel domain protein
LEO80_06470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LEO80_06470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO80_06470	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO80_06470	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO80_06475	COG2841	Protein conserved in bacteria
LEO80_06485	COG0534	Mate efflux family protein
LEO80_06520	COG1309	transcriptional regulator
LEO80_06535	COG0791	NLP P60 protein
LEO80_06540	COG0583	DNA-binding transcription factor activity
LEO80_06560	COG0500	methyltransferase
LEO80_06565	COG4106	trans-aconitate 2-methyltransferase activity
LEO80_06570	COG1801	Protein of unknown function DUF72
LEO80_06575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEO80_06580	COG0217	transcriptional regulatory protein
LEO80_06585	COG2194	sulfuric ester hydrolase activity
LEO80_06590	COG1846	Transcriptional regulator
LEO80_06590	COG1940	carbohydrate kinase activity
LEO80_06595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO80_06600	COG0363	glucosamine-6-phosphate deaminase activity
LEO80_06605	COG2190	(PTS) system
LEO80_06605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO80_06605	COG1263	PTS System
LEO80_06615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO80_06620	COG0735	belongs to the Fur family
LEO80_06630	COG0716	FMN binding
LEO80_06645	COG0596	Alpha beta hydrolase
LEO80_06650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LEO80_06655	COG0033	Phosphoglucomutase
LEO80_06665	COG1846	Transcriptional regulator
LEO80_06670	COG2951	lytic endotransglycosylase activity
LEO80_06675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEO80_06680	COG4136	ATPase activity
LEO80_06690	COG4134	Bacterial extracellular solute-binding protein
LEO80_06695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO80_06700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO80_06710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO80_06720	COG0729	surface antigen
LEO80_06725	COG2911	Protein conserved in bacteria
LEO80_06745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEO80_06755	COG0741	lytic transglycosylase activity
LEO80_06770	COG1607	acyl-coa hydrolase
LEO80_06785	COG0741	lytic transglycosylase activity
LEO80_06785	COG1388	LysM domain
LEO80_06795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO80_06800	COG2226	methyltransferase
LEO80_06805	COG0328	RNA-DNA hybrid ribonuclease activity
LEO80_06845	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO80_06860	COG5642	Protein of unknown function (DUF2384)
LEO80_06865	COG2850	peptidyl-arginine hydroxylation
LEO80_06915	COG0210	DNA helicase
LEO80_06955	COG4974	Belongs to the 'phage' integrase family
LEO80_06960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO80_06970	COG0784	Response regulator, receiver
LEO80_06970	COG3437	response regulator, receiver
LEO80_06975	COG1960	acyl-CoA dehydrogenase activity
LEO80_06980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO80_06985	COG0121	glutamine amidotransferase
LEO80_06995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LEO80_07020	COG2197	response regulator
LEO80_07025	COG3850	Histidine kinase
LEO80_07030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO80_07035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO80_07035	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO80_07045	COG0243	molybdopterin cofactor binding
LEO80_07050	COG0437	4 iron, 4 sulfur cluster binding
LEO80_07055	COG0348	domain, Protein
LEO80_07065	COG3005	denitrification pathway
LEO80_07070	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO80_07075	COG0315	cyclic pyranopterin monophosphate synthase activity
LEO80_07080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEO80_07085	COG0314	molybdopterin synthase activity
LEO80_07100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LEO80_07105	COG2267	carboxylic ester hydrolase activity
LEO80_07110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO80_07120	COG0302	gtp cyclohydrolase
LEO80_07125	COG0840	transmembrane signaling receptor activity
LEO80_07130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEO80_07140	COG0583	DNA-binding transcription factor activity
LEO80_07155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LEO80_07170	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO80_07175	COG1166	arginine decarboxylase activity
LEO80_07210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LEO80_07215	COG1187	pseudouridine synthase activity
LEO80_07220	COG2807	transmembrane transport
LEO80_07230	COG0583	DNA-binding transcription factor activity
LEO80_07250	COG2979	Protein of unknown function (DUF533)
LEO80_07265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO80_07275	COG5433	transposase activity
LEO80_07285	COG1294	oxidase, subunit
LEO80_07295	COG2814	Major facilitator Superfamily
LEO80_07300	COG0656	L-ascorbic acid biosynthetic process
LEO80_07320	COG0583	DNA-binding transcription factor activity
LEO80_07325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEO80_07330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO80_07345	COG2271	Major facilitator Superfamily
LEO80_07350	COG1349	DNA-binding transcription factor activity
LEO80_07360	COG0584	glycerophosphoryl diester phosphodiesterase
LEO80_07365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO80_07370	COG0287	Prephenate dehydrogenase
LEO80_07370	COG1605	Chorismate mutase
LEO80_07380	COG3085	chromosome segregation
LEO80_07385	COG4574	serine-type endopeptidase inhibitor activity
LEO80_07405	COG0675	Transposase, IS605 OrfB family
LEO80_07415	COG4771	TonB-dependent receptor
LEO80_07420	COG3083	sulfuric ester hydrolase activity
LEO80_07425	COG3082	Protein of unknown function (DUF1414)
LEO80_07430	COG3081	Nucleoid-associated protein
LEO80_07440	COG1175	transmembrane transport
LEO80_07445	COG3833	ABC-type maltose transport systems, permease component
LEO80_07450	COG3842	ATPase activity
LEO80_07460	COG0596	Alpha beta hydrolase
LEO80_07465	COG3385	transposase activity
LEO80_07480	COG0425	Belongs to the sulfur carrier protein TusA family
LEO80_07485	COG4783	chaperone-mediated protein folding
LEO80_07495	COG1393	Belongs to the ArsC family
LEO80_07515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_07520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO80_07525	COG2431	L-lysine efflux transmembrane transporter activity
LEO80_07535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_07545	COG4160	amino acid transport
LEO80_07555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO80_07565	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO80_07570	COG2373	Large extracellular alpha-helical protein
LEO80_07575	COG4953	penicillin-binding protein 1C
LEO80_07585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO80_07585	COG0301	tRNA thio-modification
LEO80_07605	COG1334	flagellar protein FlaG
LEO80_07650	COG4584	PFAM Integrase catalytic
LEO80_07655	COG1484	DNA-dependent DNA replication
LEO80_07675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO80_07685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO80_07700	COG0346	lactoylglutathione lyase activity
LEO80_07705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEO80_07710	COG4660	Part of a membrane complex involved in electron transport
LEO80_07715	COG4659	FMN binding
LEO80_07720	COG4658	electron transport chain
LEO80_07730	COG2878	Part of a membrane complex involved in electron transport
LEO80_07735	COG4657	Part of a membrane complex involved in electron transport
LEO80_07740	COG0697	spore germination
LEO80_07755	COG3385	transposase activity
LEO80_07775	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO80_07795	COG0436	Aminotransferase
LEO80_07805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEO80_07810	COG2027	D-alanyl-D-alanine carboxypeptidase
LEO80_07815	COG1061	Type III restriction enzyme res subunit
LEO80_07820	COG1566	PFAM secretion protein HlyD family protein
LEO80_07840	COG0675	Transposase, IS605 OrfB family
LEO80_07845	COG3264	Mechanosensitive ion channel
LEO80_07845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO80_07850	COG1966	Carbon starvation protein
LEO80_07855	COG3279	Response regulator of the LytR AlgR family
LEO80_07860	COG3275	phosphorelay sensor kinase activity
LEO80_07870	COG1454	alcohol dehydrogenase
LEO80_07870	COG1012	belongs to the aldehyde dehydrogenase family
LEO80_07875	COG2095	MarC family integral membrane protein
LEO80_07885	COG0601	transmembrane transport
LEO80_07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO80_07895	COG0444	Belongs to the ABC transporter superfamily
LEO80_07905	COG0861	Integral membrane protein TerC family
LEO80_07910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO80_07920	COG1301	dicarboxylic acid transport
LEO80_07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEO80_07960	COG0537	adenosine 5'-monophosphoramidase activity
LEO80_07995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO80_08000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO80_08015	COG2354	Protein conserved in bacteria
LEO80_08020	COG1164	Oligoendopeptidase f
LEO80_08025	COG1164	Oligoendopeptidase f
LEO80_08035	COG1252	NADH dehydrogenase
LEO80_08040	COG0393	Putative heavy-metal-binding
LEO80_08055	COG1368	sulfuric ester hydrolase activity
LEO80_08065	COG0527	aspartate kinase activity
LEO80_08070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO80_08070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEO80_08075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO80_08100	COG0583	DNA-binding transcription factor activity
LEO80_08105	COG1620	l-lactate permease
LEO80_08110	COG0247	lactate metabolic process
LEO80_08115	COG1139	Iron-sulfur cluster binding protein
LEO80_08145	COG3039	Transposase
LEO80_08155	COG0577	efflux transmembrane transporter activity
LEO80_08160	COG1136	(ABC) transporter
LEO80_08185	COG2814	Major facilitator Superfamily
LEO80_08205	COG0672	)-iron permease
LEO80_08240	COG2308	Evidence 4 Homologs of previously reported genes of
LEO80_08260	COG0659	secondary active sulfate transmembrane transporter activity
LEO80_08270	COG3039	Transposase
LEO80_08275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEO80_08280	COG0326	Molecular chaperone. Has ATPase activity
LEO80_08285	COG0563	adenylate kinase activity
LEO80_08290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEO80_08295	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LEO80_08300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO80_08305	COG0840	transmembrane signaling receptor activity
LEO80_08320	COG5001	Diguanylate cyclase
LEO80_08320	COG3300	MHYT domain
LEO80_08360	COG3433	isochorismatase activity
LEO80_08360	COG1535	isochorismatase
LEO80_08365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO80_08370	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_08380	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_08380	COG0318	PFAM AMP-dependent synthetase and ligase
LEO80_08380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO80_08380	COG0300	oxidoreductase activity
LEO80_08380	COG3321	synthase
LEO80_08395	COG1120	ATPase activity
LEO80_08400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO80_08405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO80_08410	COG4771	TonB-dependent receptor
LEO80_08450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LEO80_08455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEO80_08460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO80_08465	COG0861	Integral membrane protein TerC family
LEO80_08480	COG1022	Amp-dependent synthetase and ligase
LEO80_08485	COG0295	cytidine deaminase activity
LEO80_08490	COG1346	cytolysis
LEO80_08495	COG1380	Effector of murein hydrolase LrgA
LEO80_08500	COG3345	alpha-galactosidase
LEO80_08510	COG2925	Exonuclease
LEO80_08535	COG5433	transposase activity
LEO80_08545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO80_08600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO80_08605	COG0392	lysyltransferase activity
LEO80_08605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEO80_08620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO80_08625	COG0436	Aminotransferase
LEO80_08630	COG0583	DNA-binding transcription factor activity
LEO80_08635	COG2160	L-arabinose isomerase activity
LEO80_08645	COG1069	ribulokinase activity
LEO80_08650	COG1879	ABC-type sugar transport system periplasmic component
LEO80_08655	COG1129	ABC transporter
LEO80_08660	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO80_08675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO80_08680	COG0254	rRNA binding
LEO80_08695	COG1451	nucleotide metabolic process
LEO80_08710	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO80_08720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO80_08720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LEO80_08725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO80_08740	COG3385	transposase activity
LEO80_08750	COG2009	succinate dehydrogenase
LEO80_08755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LEO80_08770	COG0567	Dehydrogenase, E1 component
LEO80_08775	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO80_08780	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO80_08785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LEO80_08805	COG2983	Belongs to the UPF0260 family
LEO80_08810	COG1882	Formate acetyltransferase
LEO80_08815	COG2116	formate transmembrane transporter activity
LEO80_08820	COG1944	ATP diphosphatase activity
LEO80_08835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO80_08840	COG1278	Cold shock
LEO80_08845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEO80_08850	COG0542	response to heat
LEO80_08855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEO80_08860	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LEO80_08865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEO80_08870	COG3134	Outer membrane lipoprotein
LEO80_08875	COG3706	GGDEF domain
LEO80_08880	COG0492	ferredoxin-NADP+ reductase activity
LEO80_08885	COG0686	Belongs to the AlaDH PNT family
LEO80_08895	COG1674	ftsk spoiiie
LEO80_08895	COG0531	amino acid
LEO80_08900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LEO80_08905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEO80_08910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEO80_08915	COG1286	toxin biosynthetic process
LEO80_08920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEO80_08925	COG2723	6-phospho-beta-galactosidase activity
LEO80_08930	COG1263	PTS System
LEO80_08930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO80_08935	COG1609	Transcriptional regulator
LEO80_08945	COG4172	Belongs to the ABC transporter superfamily
LEO80_08955	COG4171	peptide transport system, permease
LEO80_08970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LEO80_08975	COG1842	Phage shock protein A
LEO80_08990	COG3106	COG3106 Predicted ATPase
LEO80_08995	COG3768	UPF0283 membrane protein
LEO80_09005	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEO80_09020	COG2199	diguanylate cyclase activity
LEO80_09025	COG2885	chlorophyll binding
LEO80_09055	COG1874	Beta-galactosidase
LEO80_09055	COG0366	Alpha amylase catalytic
LEO80_09065	COG0675	Transposase, IS605 OrfB family
LEO80_09080	COG0516	GMP reductase activity
LEO80_09080	COG0517	IMP dehydrogenase activity
LEO80_09085	COG0519	Catalyzes the synthesis of GMP from XMP
LEO80_09085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO80_09100	COG1846	Transcriptional regulator
LEO80_09110	COG0500	methyltransferase
LEO80_09120	COG2062	phosphohistidine phosphatase, SixA
LEO80_09130	COG0697	spore germination
LEO80_09145	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEO80_09150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEO80_09160	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO80_09165	COG1136	(ABC) transporter
LEO80_09170	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO80_09175	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LEO80_09185	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEO80_09190	COG0740	serine-type endopeptidase activity
LEO80_09195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEO80_09200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEO80_09205	COG0776	regulation of translation
LEO80_09210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO80_09215	COG0488	(ABC) transporter
LEO80_09220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO80_09225	COG3162	membrane
LEO80_09240	COG1024	Enoyl-CoA hydratase
LEO80_09245	COG1115	amino acid carrier protein
LEO80_09255	COG3228	Belongs to the MtfA family
LEO80_09260	COG1584	GPR1 FUN34 yaaH family protein
LEO80_09285	COG1024	Enoyl-CoA hydratase
LEO80_09290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEO80_09295	COG1960	acyl-CoA dehydrogenase activity
LEO80_09305	COG1960	acyl-CoA dehydrogenase activity
LEO80_09310	COG1024	Enoyl-CoA hydratase
LEO80_09315	COG1024	Enoyl-CoA hydratase
LEO80_09325	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_09335	COG0730	response to heat
LEO80_09350	COG1464	Belongs to the NlpA lipoprotein family
LEO80_09360	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO80_09365	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO80_09370	COG1129	ABC transporter
LEO80_09375	COG1879	ABC-type sugar transport system periplasmic component
LEO80_09380	COG0583	DNA-binding transcription factor activity
LEO80_09395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO80_09400	COG0243	molybdopterin cofactor binding
LEO80_09410	COG0583	DNA-binding transcription factor activity
LEO80_09415	COG2723	6-phospho-beta-galactosidase activity
LEO80_09425	COG0583	DNA-binding transcription factor activity
LEO80_09430	COG0583	DNA-binding transcription factor activity
LEO80_09445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LEO80_09450	COG0673	inositol 2-dehydrogenase activity
LEO80_09455	COG0583	DNA-binding transcription factor activity
LEO80_09465	COG1560	Kdo2-lipid A biosynthetic process
LEO80_09470	COG1560	Kdo2-lipid A biosynthetic process
LEO80_09490	COG0417	DNA replication proofreading
LEO80_09520	COG0534	Mate efflux family protein
LEO80_09530	COG0307	riboflavin synthase, alpha
LEO80_09545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO80_09550	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEO80_09555	COG0697	spore germination
LEO80_09560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO80_09590	COG0675	Transposase, IS605 OrfB family
LEO80_09595	COG2996	Protein conserved in bacteria
LEO80_09610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO80_09615	COG3099	Belongs to the UPF0263 family
LEO80_09620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEO80_09625	COG2894	cell division
LEO80_09630	COG0850	regulation of cytokinetic process
LEO80_09635	COG3100	YcgL domain-containing protein
LEO80_09640	COG2951	lytic endotransglycosylase activity
LEO80_09645	COG3385	transposase activity
LEO80_09650	COG1760	l-serine dehydratase
LEO80_09655	COG1760	l-serine dehydratase
LEO80_09660	COG3123	guanosine phosphorylase activity
LEO80_09665	COG1301	dicarboxylic acid transport
LEO80_09680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LEO80_09685	COG2067	long-chain fatty acid transport protein
LEO80_09690	COG2067	long-chain fatty acid transport protein
LEO80_09700	COG1595	DNA-templated transcription, initiation
LEO80_09730	COG0714	Associated with various cellular activities
LEO80_09735	COG0183	Belongs to the thiolase family
LEO80_09740	COG1024	Enoyl-CoA hydratase
LEO80_09740	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO80_09750	COG4681	YaeQ
LEO80_09760	COG2932	Transcriptional regulator
LEO80_09875	COG0640	Transcriptional regulator
LEO80_09885	COG4373	Mu-like prophage FluMu protein gp28
LEO80_09890	COG4383	Mu-like prophage protein gp29
LEO80_09910	COG0758	DNA mediated transformation
LEO80_09915	COG4388	Caudovirus prohead serine protease
LEO80_09930	COG4388	Caudovirus prohead serine protease
LEO80_09935	COG4397	Mu-like prophage major head subunit gpT
LEO80_09965	COG2801	Transposase and inactivated derivatives
LEO80_10005	COG5433	transposase activity
LEO80_10045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO80_10060	COG3134	Outer membrane lipoprotein
LEO80_10075	COG0675	Transposase, IS605 OrfB family
LEO80_10085	COG2378	regulation of single-species biofilm formation
LEO80_10095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEO80_10095	COG0140	phosphoribosyl-ATP diphosphatase activity
LEO80_10100	COG0107	imidazoleglycerol-phosphate synthase activity
LEO80_10105	COG2205	protein histidine kinase activity
LEO80_10105	COG2198	Histidine kinase
LEO80_10105	COG0784	Response regulator, receiver
LEO80_10115	COG3437	response regulator, receiver
LEO80_10120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEO80_10125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO80_10130	COG0131	Imidazoleglycerol-phosphate dehydratase
LEO80_10130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO80_10135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEO80_10140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEO80_10145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEO80_10155	COG1199	ATP-dependent helicase activity
LEO80_10160	COG1214	PFAM Peptidase M22, glycoprotease
LEO80_10170	COG0596	Alpha beta hydrolase
LEO80_10175	COG0318	PFAM AMP-dependent synthetase and ligase
LEO80_10190	COG0697	spore germination
LEO80_10200	COG0675	Transposase, IS605 OrfB family
LEO80_10215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO80_10220	COG2832	Protein of unknown function (DUF454)
LEO80_10225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEO80_10235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEO80_10240	COG0583	DNA-binding transcription factor activity
LEO80_10250	COG3314	Sporulation integral membrane protein YlbJ
LEO80_10265	COG2197	response regulator
LEO80_10270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO80_10270	COG0517	IMP dehydrogenase activity
LEO80_10270	COG0617	tRNA 3'-terminal CCA addition
LEO80_10275	COG1643	Atp-dependent helicase
LEO80_10285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEO80_10300	COG0675	Transposase, IS605 OrfB family
LEO80_10305	COG0784	Response regulator, receiver
LEO80_10305	COG2205	protein histidine kinase activity
LEO80_10305	COG5002	protein histidine kinase activity
LEO80_10325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO80_10330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LEO80_10335	COG0709	Synthesizes selenophosphate from selenide and ATP
LEO80_10350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO80_10355	COG0840	transmembrane signaling receptor activity
LEO80_10365	COG1254	Belongs to the acylphosphatase family
LEO80_10375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO80_10375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO80_10380	COG0489	protein tyrosine kinase activity
LEO80_10385	COG0572	uridine kinase
LEO80_10390	COG0717	Belongs to the dCTP deaminase family
LEO80_10395	COG0306	phosphate transporter
LEO80_10400	COG1530	ribonuclease E activity
LEO80_10405	COG0564	pseudouridine synthase activity
LEO80_10420	COG1399	metal-binding, possibly nucleic acid-binding protein
LEO80_10425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEO80_10430	COG0416	fatty acid biosynthetic process
LEO80_10435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO80_10445	COG1028	Short-chain dehydrogenase reductase Sdr
LEO80_10450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO80_10455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO80_10460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEO80_10465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEO80_10470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEO80_10475	COG0470	DNA polymerase III
LEO80_10480	COG0084	hydrolase, TatD family'
LEO80_10495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO80_10495	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEO80_10525	COG4115	mRNA cleavage
LEO80_10530	COG2161	toxin-antitoxin pair type II binding
LEO80_10570	COG1132	(ABC) transporter
LEO80_10610	COG1695	Transcriptional regulator
LEO80_10635	COG3173	Aminoglycoside phosphotransferase
LEO80_10655	COG0840	transmembrane signaling receptor activity
LEO80_10670	COG3008	intermembrane lipid transfer
LEO80_10675	COG2995	paraquat-inducible protein a
LEO80_10685	COG3141	response to X-ray
LEO80_10730	COG1074	ATP-dependent DNA helicase activity
LEO80_10735	COG5433	transposase activity
LEO80_10745	COG2831	hemolysin activation secretion protein
LEO80_10775	COG5433	transposase activity
LEO80_10795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LEO80_10870	COG3385	transposase activity
LEO80_10875	COG3385	transposase activity
LEO80_10885	COG5433	transposase activity
LEO80_10890	COG5499	transcription regulator containing HTH domain
LEO80_10925	COG1067	ATP-dependent peptidase activity
LEO80_10930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO80_10945	COG0488	(ABC) transporter
LEO80_10955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO80_10955	COG0116	Belongs to the methyltransferase superfamily
LEO80_10965	COG0167	dihydroorotate dehydrogenase activity
LEO80_10970	COG2902	Dehydrogenase
LEO80_10980	COG0308	aminopeptidase N
LEO80_10990	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LEO80_10995	COG1956	GAF domain-containing protein
LEO80_11005	COG3278	Belongs to the heme-copper respiratory oxidase family
LEO80_11020	COG2010	Cytochrome c
LEO80_11030	COG2217	Heavy metal translocating P-type atpase
LEO80_11045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO80_11050	COG0589	response to stress
LEO80_11055	COG0037	tRNA processing
LEO80_11070	COG0625	glutathione transferase activity
LEO80_11075	COG1869	D-ribose catabolic process
LEO80_11080	COG1129	ABC transporter
LEO80_11085	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO80_11090	COG1879	ABC-type sugar transport system periplasmic component
LEO80_11095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO80_11100	COG1609	Transcriptional regulator
LEO80_11110	COG0675	Transposase, IS605 OrfB family
LEO80_11145	COG0776	regulation of translation
LEO80_11150	COG0072	phenylalanine-tRNA ligase activity
LEO80_11150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO80_11155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEO80_11160	COG4974	Belongs to the 'phage' integrase family
LEO80_11175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEO80_11180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEO80_11185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEO80_11190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEO80_11220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO80_11230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO80_11235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO80_11240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO80_11245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEO80_11250	COG3313	Fe-S protein
LEO80_11255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LEO80_11255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO80_11255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO80_11260	COG1105	Belongs to the carbohydrate kinase PfkB family
LEO80_11265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_11265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_11270	COG1609	Transcriptional regulator
LEO80_11275	COG0814	amino acid
LEO80_11285	COG5654	RES domain protein
LEO80_11290	COG0513	Belongs to the DEAD box helicase family
LEO80_11300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEO80_11305	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO80_11310	COG2840	Smr protein MutS2
LEO80_11345	COG2824	Alkylphosphonate utilization operon protein PhnA
LEO80_11370	COG0675	Transposase, IS605 OrfB family
LEO80_11405	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO80_11410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LEO80_11420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO80_11425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LEO80_11435	COG0205	6-phosphofructokinase activity
LEO80_11450	COG1011	Hydrolase
LEO80_11455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO80_11475	COG3593	DNA synthesis involved in DNA repair
LEO80_11490	COG0583	DNA-binding transcription factor activity
LEO80_11495	COG0730	response to heat
LEO80_11510	COG3148	PFAM DTW domain containing protein
LEO80_11515	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEO80_11525	COG0386	Belongs to the glutathione peroxidase family
LEO80_11530	COG0513	Belongs to the DEAD box helicase family
LEO80_11570	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO80_11595	COG0675	Transposase, IS605 OrfB family
LEO80_11615	COG2501	S4 domain
LEO80_11640	COG1132	(ABC) transporter
LEO80_11645	COG1132	(ABC) transporter
LEO80_11655	COG3118	belongs to the thioredoxin family
LEO80_11660	COG0471	metal ion transport
LEO80_11670	COG0058	SHG alpha-glucan phosphorylase activity
LEO80_11705	COG0814	amino acid
LEO80_11710	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LEO80_11715	COG0514	ATP-dependent DNA helicase (RecQ)
LEO80_11720	COG2766	serine protein kinase
LEO80_11725	COG2718	Belongs to the UPF0229 family
LEO80_11730	COG2719	SpoVR family
LEO80_11735	COG2186	Transcriptional regulator
LEO80_11740	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO80_11745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO80_11750	COG0586	Pfam SNARE associated Golgi protein
LEO80_11760	COG0556	nucleotide-excision repair
LEO80_11770	COG2985	domain, Protein
LEO80_11770	COG0569	domain protein
LEO80_11775	COG0739	heme binding
LEO80_11775	COG0741	lytic transglycosylase activity
LEO80_11775	COG1196	nuclear chromosome segregation
LEO80_11780	COG0675	Transposase, IS605 OrfB family
LEO80_11790	COG3181	Tripartite tricarboxylate transporter family receptor
LEO80_11805	COG4565	transcriptional regulatory protein
LEO80_11810	COG3290	protein histidine kinase activity
LEO80_11815	COG1940	carbohydrate kinase activity
LEO80_11815	COG1846	Transcriptional regulator
LEO80_11820	COG0840	transmembrane signaling receptor activity
LEO80_11825	COG3012	SEC-C Motif Domain Protein
LEO80_11830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEO80_11835	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEO80_11840	COG0247	lactate metabolic process
LEO80_11860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO80_11865	COG0437	4 iron, 4 sulfur cluster binding
LEO80_11870	COG3301	Polysulphide reductase, NrfD
LEO80_11875	COG1138	Cytochrome C-type biogenesis protein
LEO80_11880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO80_11885	COG4235	cytochrome complex assembly
LEO80_11885	COG3088	subunit of a heme lyase
LEO80_11900	COG3046	protein related to deoxyribodipyrimidine photolyase
LEO80_11905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO80_11910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO80_11910	COG0517	IMP dehydrogenase activity
LEO80_11910	COG0617	tRNA 3'-terminal CCA addition
LEO80_11920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEO80_11925	COG0583	DNA-binding transcription factor activity
LEO80_11935	COG4774	siderophore transport
LEO80_11950	COG0675	Transposase, IS605 OrfB family
LEO80_11960	COG0583	DNA-binding transcription factor activity
LEO80_11965	COG2910	NAD(P)H-binding
LEO80_11980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEO80_12010	COG2226	methyltransferase
LEO80_12020	COG3250	beta-galactosidase activity
LEO80_12025	COG2223	nitrite transmembrane transporter activity
LEO80_12030	COG4372	Transposase
LEO80_12055	COG3039	Transposase
LEO80_12060	COG3385	transposase activity
LEO80_12065	COG3385	transposase activity
LEO80_12070	COG1609	Transcriptional regulator
LEO80_12075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO80_12080	COG1085	galactose-1-phosphate uridylyltransferase
LEO80_12085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO80_12090	COG0469	pyruvate kinase activity
LEO80_12120	COG4584	PFAM Integrase catalytic
LEO80_12125	COG1484	DNA-dependent DNA replication
LEO80_12150	COG5433	transposase activity
LEO80_12200	COG3550	peptidyl-serine autophosphorylation
LEO80_12210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LEO80_12215	COG1349	DNA-binding transcription factor activity
LEO80_12230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LEO80_12250	COG1435	thymidine kinase activity
LEO80_12255	COG1757	Na H antiporter
LEO80_12260	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO80_12265	COG2096	Adenosyltransferase
LEO80_12270	COG3530	Putative quorum-sensing-regulated virulence factor
LEO80_12275	COG0602	queuosine metabolic process
LEO80_12280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEO80_12300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LEO80_12310	COG0776	regulation of translation
LEO80_12315	COG0539	negative regulation of cytoplasmic translation
LEO80_12320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEO80_12325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO80_12355	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LEO80_12360	COG3300	MHYT domain
LEO80_12360	COG5001	Diguanylate cyclase
LEO80_12370	COG0583	DNA-binding transcription factor activity
LEO80_12375	COG0745	RESPONSE REGULATOR receiver
LEO80_12400	COG4989	oxidoreductase activity
LEO80_12405	COG0724	RNA recognition motif
LEO80_12415	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LEO80_12425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEO80_12445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO80_12450	COG1360	Flagellar Motor Protein
LEO80_12455	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO80_12460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO80_12465	COG0649	NAD binding
LEO80_12465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO80_12480	COG1034	ATP synthesis coupled electron transport
LEO80_12485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LEO80_12490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO80_12495	COG0839	Belongs to the complex I subunit 6 family
LEO80_12500	COG0713	ATP synthesis coupled electron transport
LEO80_12510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO80_12515	COG1007	ATP synthesis coupled electron transport
LEO80_12520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEO80_12520	COG0047	phosphoribosylformylglycinamidine synthase activity
LEO80_12525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO80_12530	COG1645	bacterial-type flagellum-dependent swarming motility
LEO80_12535	COG1160	GTP binding
LEO80_12540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO80_12545	COG2976	Protein conserved in bacteria
LEO80_12550	COG0124	histidyl-tRNA synthetase
LEO80_12560	COG1426	Protein conserved in bacteria
LEO80_12570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEO80_12575	COG0105	UTP biosynthetic process
LEO80_12590	COG0633	Ferredoxin
LEO80_12595	COG0443	Heat shock 70 kDa protein
LEO80_12600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO80_12610	COG0822	iron-sulfur transferase activity
LEO80_12615	COG1104	cysteine desulfurase activity
LEO80_12630	COG3154	lipid carrier protein
LEO80_12635	COG0826	peptidase U32
LEO80_12640	COG0826	peptidase U32
LEO80_12650	COG2897	thiosulfate sulfurtransferase activity
LEO80_12655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO80_12660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO80_12665	COG1862	Preprotein translocase
LEO80_12670	COG0343	queuine tRNA-ribosyltransferase activity
LEO80_12675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEO80_12680	COG0517	IMP dehydrogenase activity
LEO80_12685	COG0450	alkyl hydroperoxide reductase
LEO80_12690	COG3634	alkyl hydroperoxide reductase activity
LEO80_12730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO80_12740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEO80_12760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO80_12760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO80_12765	COG0509	glycine decarboxylation via glycine cleavage system
LEO80_12770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEO80_12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO80_12780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO80_12800	COG2814	Major facilitator Superfamily
LEO80_12805	COG0444	Belongs to the ABC transporter superfamily
LEO80_12810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO80_12815	COG0601	transmembrane transport
LEO80_12825	COG0625	glutathione transferase activity
LEO80_12830	COG0625	glutathione transferase activity
LEO80_12840	COG0483	inositol monophosphate 1-phosphatase activity
LEO80_12855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO80_12860	COG2056	Na+-H+ antiporter family
LEO80_12865	COG2814	Major facilitator Superfamily
LEO80_12870	COG0583	DNA-binding transcription factor activity
LEO80_12875	COG5001	Diguanylate cyclase
LEO80_12890	COG2050	protein possibly involved in aromatic compounds catabolism
LEO80_12905	COG0247	lactate metabolic process
LEO80_12905	COG0277	FAD linked oxidase domain protein
LEO80_12920	COG1253	flavin adenine dinucleotide binding
LEO80_12925	COG1902	pentaerythritol trinitrate reductase activity
LEO80_12930	COG0604	alcohol dehydrogenase
LEO80_12935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO80_12940	COG0647	UMP catabolic process
LEO80_12950	COG0367	asparagine synthase
LEO80_12965	COG0625	glutathione transferase activity
LEO80_12975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LEO80_12990	COG0564	pseudouridine synthase activity
LEO80_12995	COG5001	Diguanylate cyclase
LEO80_13000	COG0840	transmembrane signaling receptor activity
LEO80_13005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LEO80_13045	COG0670	Belongs to the BI1 family
LEO80_13055	COG1289	transmembrane transporter activity
LEO80_13060	COG2920	part of a sulfur-relay system
LEO80_13065	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LEO80_13070	COG0285	dihydrofolate synthase activity
LEO80_13075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEO80_13080	COG0101	tRNA pseudouridine synthase activity
LEO80_13090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO80_13095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO80_13105	COG1464	Belongs to the NlpA lipoprotein family
LEO80_13125	COG1119	ATPase activity
LEO80_13130	COG0574	Belongs to the PEP-utilizing enzyme family
LEO80_13130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO80_13135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LEO80_13145	COG1113	amino acid transport
LEO80_13165	COG1484	DNA-dependent DNA replication
LEO80_13170	COG4584	PFAM Integrase catalytic
LEO80_13210	COG1242	4 iron, 4 sulfur cluster binding
LEO80_13215	COG0069	glutamate synthase activity
LEO80_13215	COG0067	glutamate synthase
LEO80_13215	COG0070	glutamate synthase
LEO80_13220	COG0493	'glutamate synthase
LEO80_13225	COG1126	abc transporter atp-binding protein
LEO80_13230	COG0765	amino acid transport
LEO80_13260	COG4104	PAAR repeat-containing protein
LEO80_13270	COG0513	Belongs to the DEAD box helicase family
LEO80_13295	COG3039	Transposase
LEO80_13305	COG3706	GGDEF domain
LEO80_13310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO80_13315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEO80_13320	COG0505	Belongs to the CarA family
LEO80_13325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEO80_13335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEO80_13340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEO80_13345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO80_13350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEO80_13355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO80_13360	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LEO80_13390	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LEO80_13400	COG0023	Translation Initiation Factor
LEO80_13405	COG2119	membrane
LEO80_13440	COG2199	diguanylate cyclase activity
LEO80_13440	COG2203	Gaf domain
LEO80_13480	COG1484	DNA-dependent DNA replication
LEO80_13485	COG4584	PFAM Integrase catalytic
LEO80_13510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO80_13520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO80_13525	COG2261	transglycosylase associated protein
LEO80_13530	COG1309	transcriptional regulator
LEO80_13535	COG0604	alcohol dehydrogenase
LEO80_13575	COG0322	excinuclease ABC activity
LEO80_13580	COG2197	response regulator
LEO80_13585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEO80_13590	COG2835	tetraacyldisaccharide 4'-kinase activity
LEO80_13595	COG1663	tetraacyldisaccharide 4'-kinase activity
LEO80_13600	COG1132	(ABC) transporter
LEO80_13605	COG2333	competence protein COMEC
LEO80_13605	COG0658	competence protein
LEO80_13620	COG0433	COG0433 Predicted ATPase
LEO80_13625	COG1448	Aminotransferase
LEO80_13640	COG1199	ATP-dependent helicase activity
LEO80_13650	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEO80_13655	COG0477	Major facilitator Superfamily
LEO80_13660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEO80_13665	COG1785	Belongs to the alkaline phosphatase family
LEO80_13685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO80_13690	COG3706	GGDEF domain
LEO80_13695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_13700	COG0765	amino acid transport
LEO80_13705	COG1126	abc transporter atp-binding protein
LEO80_13720	COG0531	amino acid
LEO80_13735	COG1253	flavin adenine dinucleotide binding
LEO80_13740	COG0704	Plays a role in the regulation of phosphate uptake
LEO80_13745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEO80_13750	COG0581	inorganic phosphate transmembrane transporter activity
LEO80_13755	COG0573	inorganic phosphate transmembrane transporter activity
LEO80_13760	COG0590	tRNA wobble adenosine to inosine editing
LEO80_13775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LEO80_13795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEO80_13800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEO80_13805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEO80_13810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEO80_13835	COG2716	regulation of RNA biosynthetic process
LEO80_13840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEO80_13855	COG0675	Transposase, IS605 OrfB family
LEO80_13880	COG4786	Flagellar basal body rod
LEO80_13895	COG1815	bacterial-type flagellum-dependent cell motility
LEO80_13900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEO80_13905	COG0784	Response regulator, receiver
LEO80_13905	COG0835	chemotaxis
LEO80_13910	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LEO80_13925	COG0622	Phosphoesterase
LEO80_13930	COG0675	Transposase, IS605 OrfB family
LEO80_13935	COG0675	Transposase, IS605 OrfB family
LEO80_13945	COG4166	transmembrane transport
LEO80_13960	COG0675	Transposase, IS605 OrfB family
LEO80_13975	COG0697	spore germination
LEO80_13980	COG4166	transmembrane transport
LEO80_14010	COG1278	Cold shock
LEO80_14030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LEO80_14055	COG3132	Protein of unknown function, DUF480
LEO80_14075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO80_14095	COG0489	protein tyrosine kinase activity
LEO80_14095	COG3206	protein involved in exopolysaccharide biosynthesis
LEO80_14100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEO80_14145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LEO80_14150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LEO80_14160	COG0110	maltose O-acetyltransferase activity
LEO80_14180	COG1086	Polysaccharide biosynthesis protein
LEO80_14205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO80_14225	COG1484	DNA-dependent DNA replication
LEO80_14230	COG4584	PFAM Integrase catalytic
LEO80_14275	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEO80_14305	COG1737	Transcriptional regulator
LEO80_14310	COG0469	pyruvate kinase activity
LEO80_14320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_14325	COG1960	acyl-CoA dehydrogenase activity
LEO80_14335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEO80_14355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_14365	COG1309	transcriptional regulator
LEO80_14380	COG1946	Acyl-CoA thioesterase
LEO80_14395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEO80_14405	COG0009	L-threonylcarbamoyladenylate synthase
LEO80_14410	COG0613	PHP domain protein
LEO80_14415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEO80_14420	COG0512	Glutamine amidotransferase of anthranilate synthase
LEO80_14420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO80_14425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO80_14430	COG0134	indole-3-glycerol-phosphate synthase activity
LEO80_14430	COG0135	phosphoribosylanthranilate isomerase activity
LEO80_14435	COG0133	tryptophan synthase activity
LEO80_14440	COG0159	tryptophan synthase activity
LEO80_14445	COG3039	Transposase
LEO80_14450	COG3385	transposase activity
LEO80_14460	COG1396	sequence-specific DNA binding
LEO80_14465	COG3550	peptidyl-serine autophosphorylation
LEO80_14495	COG4521	taurine ABC transporter
LEO80_14500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LEO80_14510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEO80_14515	COG2175	clavaminate synthase activity
LEO80_14525	COG2814	Major facilitator Superfamily
LEO80_14530	COG0109	protoheme IX farnesyltransferase activity
LEO80_14535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LEO80_14540	COG1845	cytochrome c oxidase, subunit III
LEO80_14545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LEO80_14550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO80_14555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO80_14560	COG0583	DNA-binding transcription factor activity
LEO80_14575	COG0675	Transposase, IS605 OrfB family
LEO80_14590	COG1846	Transcriptional regulator
LEO80_14605	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LEO80_14620	COG0745	RESPONSE REGULATOR receiver
LEO80_14630	COG0708	Exodeoxyribonuclease III
LEO80_14645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_14650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_14665	COG0095	Lipoate-protein ligase
LEO80_14695	COG0640	Transcriptional regulator
LEO80_14705	COG0675	Transposase, IS605 OrfB family
LEO80_14720	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO80_14730	COG1285	pathogenesis
LEO80_14760	COG0484	heat shock protein binding
LEO80_14765	COG0443	Heat shock 70 kDa protein
LEO80_14770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEO80_14775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEO80_14780	COG3706	GGDEF domain
LEO80_14785	COG0497	DNA recombination
LEO80_14795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_14800	COG0577	efflux transmembrane transporter activity
LEO80_14800	COG1136	(ABC) transporter
LEO80_14805	COG1538	Outer membrane efflux protein
LEO80_14810	COG2375	cellular response to nickel ion
LEO80_14815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO80_14825	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO80_14830	COG0583	DNA-binding transcription factor activity
LEO80_14835	COG3048	D-serine ammonia-lyase activity
LEO80_14845	COG0538	isocitrate dehydrogenase activity
LEO80_14885	COG1187	pseudouridine synthase activity
LEO80_14895	COG0482	sulfurtransferase activity
LEO80_14900	COG2915	High frequency lysogenization protein hflD homolog
LEO80_14905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEO80_14910	COG2850	peptidyl-arginine hydroxylation
LEO80_14920	COG3264	Mechanosensitive ion channel
LEO80_14920	COG1196	nuclear chromosome segregation
LEO80_14950	COG0281	malic enzyme
LEO80_14955	COG0746	molybdenum cofactor guanylyltransferase activity
LEO80_14960	COG1763	Mo-molybdopterin cofactor biosynthetic process
LEO80_14965	COG1289	transmembrane transporter activity
LEO80_14970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO80_15000	COG3220	belongs to the UPF0276 family
LEO80_15010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LEO80_15025	COG2815	serine threonine protein kinase
LEO80_15025	COG0515	serine threonine protein kinase
LEO80_15035	COG4319	ketosteroid isomerase
LEO80_15040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO80_15045	COG0083	homoserine kinase activity
LEO80_15055	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LEO80_15060	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LEO80_15075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO80_15085	COG0745	RESPONSE REGULATOR receiver
LEO80_15100	COG4988	ABC transporter
LEO80_15105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LEO80_15125	COG1720	tRNA m6t6A37 methyltransferase activity
LEO80_15140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEO80_15145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEO80_15150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_15160	COG2190	(PTS) system
LEO80_15165	COG3038	cytochrome b561
LEO80_15180	COG0420	3'-5' exonuclease activity
LEO80_15185	COG1247	-acetyltransferase
LEO80_15190	COG2974	May be involved in recombination
LEO80_15200	COG0405	Gamma-glutamyltransferase
LEO80_15205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO80_15205	COG4651	solute:proton antiporter activity
LEO80_15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO80_15245	COG1917	Cupin 2, conserved barrel domain protein
LEO80_15245	COG1396	sequence-specific DNA binding
LEO80_15250	COG1012	belongs to the aldehyde dehydrogenase family
LEO80_15265	COG0531	amino acid
LEO80_15270	COG0531	amino acid
LEO80_15280	COG1283	sodium-dependent phosphate transmembrane transporter activity
LEO80_15290	COG3384	dioxygenase
LEO80_15295	COG2205	protein histidine kinase activity
LEO80_15295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_15320	COG0784	Response regulator, receiver
LEO80_15320	COG2205	protein histidine kinase activity
LEO80_15325	COG0582	viral genome integration into host DNA
LEO80_15380	COG1376	ErfK ybiS ycfS ynhG family protein
LEO80_15380	COG1388	LysM domain
LEO80_15395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LEO80_15400	COG0791	NLP P60 protein
LEO80_15410	COG3118	belongs to the thioredoxin family
LEO80_15420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO80_15425	COG0788	formyltetrahydrofolate deformylase activity
LEO80_15450	COG1196	nuclear chromosome segregation
LEO80_15450	COG0739	heme binding
LEO80_15450	COG0741	lytic transglycosylase activity
LEO80_15460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO80_15465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEO80_15470	COG0673	inositol 2-dehydrogenase activity
LEO80_15485	COG1484	DNA-dependent DNA replication
LEO80_15490	COG4584	PFAM Integrase catalytic
LEO80_15515	COG3039	Transposase
LEO80_15525	COG1032	radical SAM domain protein
LEO80_15530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_15540	COG3706	GGDEF domain
LEO80_15545	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO80_15550	COG0733	neurotransmitter:sodium symporter activity
LEO80_15580	COG0281	malic enzyme
LEO80_15585	COG2207	Transcriptional regulator
LEO80_15605	COG2233	PERMEase
LEO80_15610	COG0095	Lipoate-protein ligase
LEO80_15615	COG1115	amino acid carrier protein
LEO80_15620	COG0019	diaminopimelate decarboxylase activity
LEO80_15630	COG0678	peroxiredoxin activity
LEO80_15635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LEO80_15645	COG1126	abc transporter atp-binding protein
LEO80_15650	COG0765	amino acid transport
LEO80_15655	COG4597	amino acid ABC transporter
LEO80_15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_15670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO80_15675	COG1131	(ABC) transporter
LEO80_15680	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO80_15690	COG1940	carbohydrate kinase activity
LEO80_15700	COG4783	chaperone-mediated protein folding
LEO80_15710	COG5002	protein histidine kinase activity
LEO80_15715	COG0745	RESPONSE REGULATOR receiver
LEO80_15720	COG0346	lactoylglutathione lyase activity
LEO80_15725	COG3706	GGDEF domain
LEO80_15730	COG3284	Transcriptional regulator
LEO80_15745	COG0697	spore germination
LEO80_15750	COG0667	Aldo Keto reductase
LEO80_15765	COG3290	protein histidine kinase activity
LEO80_15775	COG1566	PFAM secretion protein HlyD family protein
LEO80_15800	COG0602	queuosine metabolic process
LEO80_15805	COG1328	CTP reductase activity
LEO80_15815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEO80_15820	COG3115	cell septum assembly
LEO80_15825	COG1196	nuclear chromosome segregation
LEO80_15835	COG2860	membrane
LEO80_15845	COG3108	Peptidase M15
LEO80_15850	COG2989	Protein conserved in bacteria
LEO80_15865	COG0463	Glycosyl transferase, family 2
LEO80_15880	COG0366	Alpha amylase catalytic
LEO80_15915	COG3706	GGDEF domain
LEO80_15920	COG0037	tRNA processing
LEO80_15925	COG3590	peptidase
LEO80_15935	COG0488	(ABC) transporter
LEO80_15945	COG0531	amino acid
LEO80_15950	COG0814	amino acid
LEO80_15970	COG0825	malonyl-CoA metabolic process
LEO80_15980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEO80_15985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO80_15990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO80_15995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO80_16000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO80_16015	COG0750	zinc metalloprotease
LEO80_16020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEO80_16025	COG0575	Belongs to the CDS family
LEO80_16030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEO80_16035	COG0233	cytoplasmic translational termination
LEO80_16040	COG0528	UMP kinase activity
LEO80_16045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEO80_16050	COG0052	Belongs to the universal ribosomal protein uS2 family
LEO80_16055	COG0024	Methionine aminopeptidase
LEO80_16060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEO80_16065	COG2171	N-acyltransferase activity
LEO80_16075	COG1263	PTS System
LEO80_16075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO80_16085	COG4580	involved in the transport of maltose and maltodextrins
LEO80_16100	COG0564	pseudouridine synthase activity
LEO80_16105	COG3098	single-species biofilm formation
LEO80_16130	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LEO80_16140	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO80_16140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO80_16155	COG1611	Belongs to the LOG family
LEO80_16160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO80_16165	COG0473	3-isopropylmalate dehydrogenase activity
LEO80_16175	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEO80_16190	COG0583	DNA-binding transcription factor activity
LEO80_16195	COG0840	transmembrane signaling receptor activity
LEO80_16200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO80_16215	COG1477	protein flavinylation
LEO80_16220	COG2871	sodium ion transport
LEO80_16225	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO80_16230	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO80_16235	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO80_16240	COG1805	sodium ion transport
LEO80_16245	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO80_16250	COG0271	Belongs to the BolA IbaG family
LEO80_16255	COG2813	Specifically methylates the guanine in position
LEO80_16265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO80_16275	COG2211	Major facilitator Superfamily
LEO80_16280	COG3248	Nucleoside-binding outer membrane protein
LEO80_16285	COG1666	GTP binding
LEO80_16300	COG0659	secondary active sulfate transmembrane transporter activity
LEO80_16310	COG0745	RESPONSE REGULATOR receiver
LEO80_16315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_16320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO80_16325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO80_16360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO80_16370	COG1151	hydroxylamine reductase activity
LEO80_16375	COG0783	Belongs to the Dps family
LEO80_16400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEO80_16415	COG4221	oxidoreductase activity
LEO80_16425	COG0415	Belongs to the DNA photolyase family
LEO80_16430	COG0789	Transcriptional regulator
LEO80_16435	COG3272	Protein of unknown function (DUF1722)
LEO80_16460	COG1605	Chorismate mutase
LEO80_16460	COG0077	Prephenate dehydratase
LEO80_16495	COG1349	DNA-binding transcription factor activity
LEO80_16500	COG2084	Dehydrogenase
LEO80_16505	COG3395	kinase activity
LEO80_16510	COG0235	Class ii aldolase
LEO80_16515	COG3622	Belongs to the hyi family
LEO80_16520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO80_16525	COG2610	gluconate transmembrane transporter activity
LEO80_16545	COG0300	oxidoreductase activity
LEO80_16570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEO80_16590	COG3813	Protein conserved in bacteria
LEO80_16600	COG0826	peptidase U32
LEO80_16605	COG1280	lysine exporter protein (LysE YggA)
LEO80_16615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO80_16640	COG2203	Gaf domain
LEO80_16640	COG2199	diguanylate cyclase activity
LEO80_16640	COG2200	EAL domain
LEO80_16685	COG1566	PFAM secretion protein HlyD family protein
LEO80_16695	COG0114	fumarate hydratase activity
LEO80_16705	COG0506	proline dehydrogenase activity
LEO80_16705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LEO80_16705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LEO80_16710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO80_16725	COG0737	Belongs to the 5'-nucleotidase family
LEO80_16745	COG2204	response regulator
LEO80_16750	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO80_16760	COG2900	Belongs to the SlyX family
LEO80_16765	COG1047	Peptidyl-prolyl cis-trans
LEO80_16770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LEO80_16780	COG0835	chemotaxis
LEO80_16780	COG0784	Response regulator, receiver
LEO80_16785	COG0429	hydrolase of the alpha beta-hydrolase fold
LEO80_16790	COG5001	Diguanylate cyclase
LEO80_16790	COG4251	negative regulation of phosphorylation
LEO80_16790	COG3706	GGDEF domain
LEO80_16790	COG2203	Gaf domain
LEO80_16795	COG3089	Belongs to the UPF0270 family
LEO80_16800	COG3954	Phosphoribulokinase
LEO80_16815	COG1765	OsmC-like protein
LEO80_16825	COG2226	methyltransferase
LEO80_16835	COG2205	protein histidine kinase activity
LEO80_16840	COG2814	Major facilitator Superfamily
LEO80_16865	COG0748	coenzyme F420 binding
LEO80_16870	COG3721	Heme iron utilization protein
LEO80_16880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO80_16905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEO80_16915	COG0463	Glycosyl transferase, family 2
LEO80_16925	COG0741	lytic transglycosylase activity
LEO80_16930	COG0488	(ABC) transporter
LEO80_16940	COG2252	PERMEase
LEO80_16945	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO80_16950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEO80_16955	COG3178	'Phosphotransferase
LEO80_16960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO80_16970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEO80_16975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEO80_16980	COG2967	ApaG domain
LEO80_16985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO80_16995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEO80_17000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO80_17020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEO80_17025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEO80_17030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEO80_17035	COG0142	geranyltranstransferase activity
LEO80_17040	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LEO80_17045	COG0330	HflC and HflK could
LEO80_17050	COG0330	HflC and HflK could
LEO80_17055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEO80_17060	COG1923	regulation of RNA biosynthetic process
LEO80_17065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEO80_17070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO80_17080	COG0802	atpase or kinase
LEO80_17085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEO80_17085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEO80_17105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEO80_17110	COG2011	ABC-type metal ion transport system permease component
LEO80_17115	COG1464	Belongs to the NlpA lipoprotein family
LEO80_17140	COG2205	protein histidine kinase activity
LEO80_17140	COG0784	Response regulator, receiver
LEO80_17155	COG0784	Response regulator, receiver
LEO80_17155	COG2198	Histidine kinase
LEO80_17155	COG5002	protein histidine kinase activity
LEO80_17175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LEO80_17190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEO80_17195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LEO80_17200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO80_17205	COG2716	regulation of RNA biosynthetic process
LEO80_17210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEO80_17215	COG3013	Belongs to the UPF0304 family
LEO80_17225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO80_17230	COG0280	phosphate acetyltransferase
LEO80_17230	COG0857	belongs to the CobB CobQ family
LEO80_17235	COG0440	acetolactate synthase activity
LEO80_17240	COG0028	Belongs to the TPP enzyme family
LEO80_17255	COG0671	phosphoesterase, PA-phosphatase related
LEO80_17265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO80_17270	COG0473	3-isopropylmalate dehydrogenase activity
LEO80_17275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEO80_17280	COG0066	3-isopropylmalate dehydratase activity
LEO80_17295	COG4143	(ABC) transporter
LEO80_17300	COG1178	ABC-type Fe3 transport system permease component
LEO80_17305	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEO80_17310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LEO80_17325	COG4584	PFAM Integrase catalytic
LEO80_17330	COG1484	DNA-dependent DNA replication
LEO80_17390	COG2205	protein histidine kinase activity
LEO80_17395	COG0745	RESPONSE REGULATOR receiver
LEO80_17400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO80_17405	COG0577	efflux transmembrane transporter activity
LEO80_17405	COG1136	(ABC) transporter
LEO80_17415	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LEO80_17450	COG2203	Gaf domain
LEO80_17450	COG2199	diguanylate cyclase activity
LEO80_17455	COG0513	Belongs to the DEAD box helicase family
LEO80_17465	COG1917	Cupin 2, conserved barrel domain protein
LEO80_17465	COG2207	Transcriptional regulator
LEO80_17495	COG5433	transposase activity
LEO80_17505	COG0154	amidase activity
LEO80_17510	COG2957	Belongs to the agmatine deiminase family
LEO80_17525	COG1902	pentaerythritol trinitrate reductase activity
LEO80_17530	COG0456	acetyltransferase
LEO80_17560	COG5001	Diguanylate cyclase
LEO80_17560	COG5002	protein histidine kinase activity
LEO80_17565	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LEO80_17580	COG0456	acetyltransferase
LEO80_17590	COG1022	Amp-dependent synthetase and ligase
LEO80_17595	COG3385	transposase activity
LEO80_17600	COG0095	Lipoate-protein ligase
LEO80_17615	COG1794	racemase activity, acting on amino acids and derivatives
LEO80_17630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO80_17645	COG0733	neurotransmitter:sodium symporter activity
LEO80_17650	COG0733	neurotransmitter:sodium symporter activity
LEO80_17665	COG0561	phosphatase activity
LEO80_17695	COG1846	Transcriptional regulator
LEO80_17700	COG2130	NADP-dependent
LEO80_17730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEO80_17735	COG1640	4-alpha-glucanotransferase
LEO80_17740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO80_17745	COG0676	glucose-6-phosphate 1-epimerase activity
LEO80_17750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEO80_17755	COG0840	transmembrane signaling receptor activity
LEO80_17830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LEO80_17835	COG2885	chlorophyll binding
LEO80_17840	COG0823	Involved in the tonB-independent uptake of proteins
LEO80_17855	COG0811	peptide transport
LEO80_17860	COG0824	Thioesterase
LEO80_17865	COG3790	cyd operon protein YbgE
LEO80_17870	COG4890	Cyd operon protein YbgT
LEO80_17875	COG1294	oxidase, subunit
LEO80_17880	COG1271	oxidase subunit
LEO80_17885	COG2255	four-way junction helicase activity
LEO80_17890	COG0632	four-way junction helicase activity
LEO80_17910	COG0442	prolyl-tRNA aminoacylation
LEO80_17915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO80_17920	COG4221	oxidoreductase activity
LEO80_17935	COG1024	Enoyl-CoA hydratase
LEO80_17950	COG4166	transmembrane transport
LEO80_17960	COG0840	transmembrane signaling receptor activity
LEO80_17965	COG0513	Belongs to the DEAD box helicase family
LEO80_18000	COG3118	belongs to the thioredoxin family
LEO80_18000	COG0457	Tetratricopeptide repeat
LEO80_18005	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LEO80_18010	COG1215	transferase activity, transferring glycosyl groups
LEO80_18030	COG2194	sulfuric ester hydrolase activity
LEO80_18035	COG1448	Aminotransferase
LEO80_18050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO80_18055	COG1328	CTP reductase activity
LEO80_18080	COG0840	transmembrane signaling receptor activity
LEO80_18085	COG3397	chitin binding
LEO80_18090	COG0583	DNA-binding transcription factor activity
LEO80_18095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEO80_18100	COG4208	sulfate ABC transporter
LEO80_18105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEO80_18115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEO80_18150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO80_18155	COG0564	pseudouridine synthase activity
LEO80_18175	COG0459	protein refolding
LEO80_18180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEO80_18185	COG0534	Mate efflux family protein
LEO80_18190	COG3030	protein affecting phage T7 exclusion by the F plasmid
LEO80_18195	COG1027	Aspartate ammonia-lyase
LEO80_18200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO80_18205	COG2918	glutathione biosynthetic process
LEO80_18210	COG0612	Peptidase, M16
LEO80_18215	COG1238	metal cluster binding
LEO80_18235	COG5433	transposase activity
LEO80_18270	COG0359	binds to the 23S rRNA
LEO80_18275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEO80_18280	COG0360	Binds together with S18 to 16S ribosomal RNA
LEO80_18285	COG1914	H( )-stimulated, divalent metal cation uptake system
LEO80_18295	COG2153	protein acetylation
LEO80_18305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO80_18310	COG0557	exoribonuclease II activity
LEO80_18315	COG3706	GGDEF domain
LEO80_18320	COG1854	S-ribosylhomocysteine lyase activity
LEO80_18335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEO80_18335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO80_18365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEO80_18370	COG1047	Peptidyl-prolyl cis-trans
LEO80_18375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEO80_18380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEO80_18385	COG0196	riboflavin kinase activity
LEO80_18390	COG0728	peptidoglycan biosynthetic process
LEO80_18395	COG0268	Binds directly to 16S ribosomal RNA
LEO80_18400	COG0640	Transcriptional regulator
LEO80_18405	COG0583	DNA-binding transcription factor activity
LEO80_18415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO80_18420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEO80_18425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEO80_18435	COG1051	belongs to the nudix hydrolase family
LEO80_18450	COG0335	large ribosomal subunit rRNA binding
LEO80_18455	COG0336	Belongs to the RNA methyltransferase TrmD family
LEO80_18460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEO80_18465	COG0228	four-way junction DNA binding
LEO80_18475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEO80_18480	COG4137	Cytochrome C assembly protein
LEO80_18485	COG4536	flavin adenine dinucleotide binding
LEO80_18490	COG3385	transposase activity
LEO80_18500	COG1017	nitric oxide dioxygenase activity
LEO80_18500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO80_18505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LEO80_18510	COG0039	L-malate dehydrogenase activity
LEO80_18515	COG4160	amino acid transport
LEO80_18520	COG4215	(ABC) transporter
LEO80_18525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO80_18530	COG1126	abc transporter atp-binding protein
LEO80_18535	COG1438	arginine binding
LEO80_18540	COG2837	iron assimilation
LEO80_18545	COG3842	ATPase activity
LEO80_18560	COG0347	Belongs to the P(II) protein family
LEO80_18575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO80_18580	COG0583	DNA-binding transcription factor activity
LEO80_18595	COG1929	Belongs to the glycerate kinase type-1 family
LEO80_18600	COG2610	gluconate transmembrane transporter activity
LEO80_18605	COG3835	regulator
LEO80_18610	COG3112	Uncharacterised protein family (UPF0231)
LEO80_18630	COG1872	DUF167
LEO80_18635	COG0762	integral membrane protein
LEO80_18640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEO80_18645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEO80_18660	COG3022	response to hydroperoxide
LEO80_18665	COG0513	Belongs to the DEAD box helicase family
LEO80_18670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEO80_18690	COG0735	belongs to the Fur family
LEO80_18695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO80_18710	COG0776	regulation of translation
LEO80_18715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LEO80_18725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LEO80_18740	COG0560	Phosphoserine phosphatase
LEO80_18750	COG5002	protein histidine kinase activity
LEO80_18750	COG3447	MASE1 domain protein
LEO80_18750	COG5001	Diguanylate cyclase
LEO80_18755	COG0813	purine-nucleoside phosphorylase activity
LEO80_18760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEO80_18765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LEO80_18770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO80_18780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO80_18785	COG0084	hydrolase, TatD family'
LEO80_18805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO80_18810	COG0004	ammonium transporteR
LEO80_18830	COG0795	lipopolysaccharide-transporting ATPase activity
LEO80_18835	COG0795	lipopolysaccharide-transporting ATPase activity
LEO80_18840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO80_18845	COG2927	DNA polymerase III (CHI subunit)
LEO80_18850	COG0525	valine-tRNA ligase activity
LEO80_18855	COG1253	flavin adenine dinucleotide binding
LEO80_18860	COG0586	Pfam SNARE associated Golgi protein
LEO80_18865	COG1686	Belongs to the peptidase S11 family
LEO80_18905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LEO80_18910	COG0527	aspartate kinase activity
LEO80_18915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO80_18920	COG2137	regulation of response to DNA damage stimulus
LEO80_18925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEO80_18930	COG1546	Belongs to the CinA family
LEO80_18940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEO80_18990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEO80_18995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEO80_19010	COG0477	Major facilitator Superfamily
LEO80_19020	COG0523	cobalamin synthesis protein
LEO80_19030	COG1280	lysine exporter protein (LysE YggA)
LEO80_19040	COG2200	EAL domain
LEO80_19045	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEO80_19050	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO80_19055	COG0840	transmembrane signaling receptor activity
LEO80_19060	COG0840	transmembrane signaling receptor activity
LEO80_19065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO80_19070	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO80_19075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LEO80_19080	COG2186	Transcriptional regulator
LEO80_19110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO80_19115	COG1459	type II secretion system
LEO80_19120	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LEO80_19130	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LEO80_19135	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LEO80_19140	COG0494	nUDIX hydrolase
LEO80_19150	COG0653	protein targeting
LEO80_19160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEO80_19165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEO80_19170	COG0849	cell division
LEO80_19175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LEO80_19180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO80_19185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO80_19190	COG0772	Belongs to the SEDS family
LEO80_19195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEO80_19200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO80_19205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEO80_19210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEO80_19215	COG0768	penicillin binding
LEO80_19220	COG3116	cell division
LEO80_19225	COG0275	rRNA processing
LEO80_19230	COG2001	Belongs to the MraZ family
LEO80_19240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEO80_19245	COG3107	peptidoglycan biosynthetic process
LEO80_19250	COG0792	nuclease activity
LEO80_19255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO80_19260	COG2823	Periplasmic or secreted lipoprotein
LEO80_19265	COG2969	positive regulation of protein catabolic process
LEO80_19270	COG0625	glutathione transferase activity
LEO80_19275	COG2857	Cytochrome c1
LEO80_19280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEO80_19285	COG0723	plastoquinol--plastocyanin reductase activity
LEO80_19290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEO80_19295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEO80_19300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LEO80_19310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO80_19315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO80_19375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_19380	COG1660	Displays ATPase and GTPase activities
LEO80_19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO80_19395	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LEO80_19400	COG1137	ATPase activity
LEO80_19405	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LEO80_19415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEO80_19420	COG0517	IMP dehydrogenase activity
LEO80_19420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO80_19425	COG1127	ABC transporter
LEO80_19430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEO80_19435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO80_19440	COG2854	intermembrane phospholipid transfer
LEO80_19450	COG5007	Belongs to the BolA IbaG family
LEO80_19455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEO80_19465	COG1494	fructose-1,6-bisphosphatase
LEO80_19475	COG2226	methyltransferase
LEO80_19500	COG0456	acetyltransferase
LEO80_19505	COG1733	regulation of RNA biosynthetic process
LEO80_19520	COG3932	Exopolysaccharide synthesis, ExoD
LEO80_19580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO80_19585	COG2022	thiamine diphosphate biosynthetic process
LEO80_19595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO80_19600	COG0352	thiamine-phosphate diphosphorylase activity
LEO80_19605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEO80_19620	COG0745	RESPONSE REGULATOR receiver
LEO80_19625	COG0642	Histidine kinase
LEO80_19630	COG0189	ligase activity
LEO80_19665	COG2321	neutral zinc metallopeptidase
LEO80_19675	COG0477	Major facilitator Superfamily
LEO80_19695	COG0312	modulator of DNA gyrase
LEO80_19700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO80_19705	COG3164	Protein of unknown function
LEO80_19710	COG1530	ribonuclease E activity
LEO80_19715	COG0424	maF-like protein
LEO80_19720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LEO80_19725	COG1792	Involved in formation and maintenance of cell shape
LEO80_19730	COG1077	Cell shape determining protein MreB Mrl
LEO80_19770	COG2200	EAL domain
LEO80_19775	COG0387	Pfam Sodium calcium exchanger
LEO80_19780	COG2986	histidine ammonia-lyase
LEO80_19785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LEO80_19790	COG0010	Belongs to the arginase family
LEO80_19795	COG1228	amidohydrolase
LEO80_19800	COG2188	Transcriptional regulator
LEO80_19805	COG0288	reversible hydration of carbon dioxide
LEO80_19815	COG2177	Part of the ABC transporter FtsEX involved in
LEO80_19820	COG2884	Cell division ATP-binding protein ftsE
LEO80_19825	COG0552	protein localization to endoplasmic reticulum
LEO80_19830	COG0742	ribosomal rna small subunit methyltransferase
LEO80_19855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO80_19865	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO80_19875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO80_19885	COG2095	MarC family integral membrane protein
LEO80_19900	COG1301	dicarboxylic acid transport
LEO80_19910	COG0583	DNA-binding transcription factor activity
LEO80_19925	COG3714	YhhN family
LEO80_19940	COG2358	TRAP transporter, solute receptor (TAXI family
LEO80_19945	COG1770	oligopeptidase
LEO80_19960	COG4221	oxidoreductase activity
LEO80_19965	COG0583	DNA-binding transcription factor activity
LEO80_19970	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO80_20025	COG3655	Transcriptional regulator
LEO80_20030	COG5433	transposase activity
LEO80_20045	COG3121	Chaperone
LEO80_20050	COG3539	Fimbrial protein
LEO80_20070	COG1484	DNA-dependent DNA replication
LEO80_20075	COG4584	PFAM Integrase catalytic
LEO80_20115	COG0203	ribosomal protein L17
LEO80_20120	COG0202	RNA polymerase activity
LEO80_20125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEO80_20130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEO80_20135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEO80_20140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO80_20145	COG0201	protein transport
LEO80_20150	COG0200	Binds to the 23S rRNA
LEO80_20155	COG1841	ribosomal large subunit assembly
LEO80_20160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEO80_20165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEO80_20170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEO80_20175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEO80_20180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEO80_20185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEO80_20190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEO80_20195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEO80_20200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEO80_20205	COG0255	Belongs to the universal ribosomal protein uL29 family
LEO80_20210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEO80_20215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEO80_20220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEO80_20225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEO80_20230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEO80_20235	COG0089	rRNA binding
LEO80_20240	COG0088	Forms part of the polypeptide exit tunnel
LEO80_20245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEO80_20250	COG0051	transcription antitermination factor activity, RNA binding
LEO80_20260	COG2205	protein histidine kinase activity
LEO80_20270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO80_20275	COG2183	response to ionizing radiation
LEO80_20290	COG0596	Alpha beta hydrolase
LEO80_20295	COG1040	competence protein
LEO80_20300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEO80_20300	COG0316	Belongs to the HesB IscA family
LEO80_20305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEO80_20310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LEO80_20315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO80_20320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEO80_20325	COG4942	peptidase
LEO80_20335	COG1609	Transcriptional regulator
LEO80_20350	COG0800	Aldolase
LEO80_20355	COG0129	dihydroxy-acid dehydratase activity
LEO80_20360	COG3265	gluconokinase activity
LEO80_20365	COG2610	gluconate transmembrane transporter activity
LEO80_20370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO80_20375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEO80_20385	COG0456	acetyltransferase
LEO80_20395	COG1490	D-aminoacyl-tRNA deacylase activity
LEO80_20400	COG1295	ribonuclease BN
LEO80_20405	COG1217	gtp-binding protein TYPA
LEO80_20410	COG0174	glutamine synthetase
LEO80_20420	COG3852	Histidine kinase
LEO80_20430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO80_20435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO80_20445	COG3078	GTPase activator activity
LEO80_20455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO80_20460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEO80_20465	COG0408	coproporphyrinogen oxidase activity
LEO80_20470	COG0009	L-threonylcarbamoyladenylate synthase
LEO80_20475	COG0551	DNA topoisomerase type I activity
LEO80_20480	COG2922	Belongs to the Smg family
LEO80_20485	COG0758	DNA mediated transformation
LEO80_20495	COG0242	peptide deformylase activity
LEO80_20500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO80_20505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO80_20505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO80_20510	COG0569	domain protein
LEO80_20515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO80_20520	COG1322	Protein conserved in bacteria
LEO80_20540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO80_20550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO80_20550	COG0519	Catalyzes the synthesis of GMP from XMP
LEO80_20560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO80_20565	COG1396	sequence-specific DNA binding
LEO80_20570	COG1012	belongs to the aldehyde dehydrogenase family
LEO80_20580	COG2962	Rard protein
LEO80_20590	COG1280	lysine exporter protein (LysE YggA)
LEO80_20630	COG0583	DNA-binding transcription factor activity
LEO80_20665	COG0210	DNA helicase
LEO80_20670	COG1744	ABC transporter substrate-binding protein PnrA-like
LEO80_20675	COG3845	ABC transporter
LEO80_20680	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEO80_20685	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEO80_20690	COG0583	DNA-binding transcription factor activity
LEO80_20715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEO80_20720	COG0385	Bile acid
LEO80_20725	COG0531	amino acid
LEO80_20735	COG0531	amino acid
LEO80_20740	COG2731	YhcH YjgK YiaL family protein
LEO80_20745	COG3250	beta-galactosidase activity
LEO80_20750	COG1609	Transcriptional regulator
LEO80_20785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEO80_20790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO80_20790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO80_20795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LEO80_20800	COG3074	FtsZ-dependent cytokinesis
LEO80_20810	COG1045	serine acetyltransferase
LEO80_20820	COG0745	RESPONSE REGULATOR receiver
LEO80_20825	COG2205	protein histidine kinase activity
LEO80_20830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEO80_20835	COG0534	Mate efflux family protein
LEO80_20850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO80_20855	COG2937	Belongs to the GPAT DAPAT family
LEO80_20860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEO80_20865	COG3161	chorismate lyase activity
LEO80_20870	COG1580	Controls the rotational direction of flagella during chemotaxis
LEO80_20900	COG3307	-O-antigen
LEO80_20905	COG0438	transferase activity, transferring glycosyl groups
LEO80_20910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO80_20920	COG0156	8-amino-7-oxononanoate synthase activity
LEO80_20925	COG1063	alcohol dehydrogenase
LEO80_20945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO80_20950	COG2166	iron-sulfur cluster assembly
LEO80_20955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEO80_20985	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LEO80_20990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO80_20995	COG1739	Uncharacterized protein family UPF0029
LEO80_21000	COG0006	proline dipeptidase activity
LEO80_21005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO80_21010	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO80_21010	COG1024	Enoyl-CoA hydratase
LEO80_21015	COG0183	Belongs to the thiolase family
LEO80_21045	COG0425	Belongs to the sulfur carrier protein TusA family
LEO80_21050	COG0251	oxidation-reduction process
LEO80_21065	COG2885	chlorophyll binding
LEO80_21075	COG1335	isochorismatase
LEO80_21080	COG2818	Glycosylase
LEO80_21085	COG0752	glycyl-tRNA synthetase alpha subunit
LEO80_21090	COG0751	glycine-tRNA ligase activity
LEO80_21105	COG2203	Gaf domain
LEO80_21105	COG3706	GGDEF domain
LEO80_21105	COG4251	negative regulation of phosphorylation
LEO80_21105	COG5001	Diguanylate cyclase
LEO80_21125	COG0814	amino acid
LEO80_21130	COG0814	amino acid
LEO80_21135	COG3033	Beta-eliminating lyase
LEO80_21145	COG0348	domain, Protein
LEO80_21155	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO80_21160	COG1773	rubredoxin
LEO80_21160	COG0426	domain, Protein
LEO80_21165	COG3604	Transcriptional regulator
LEO80_21170	COG1609	Transcriptional regulator
LEO80_21210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO80_21230	COG2960	long-chain fatty acid transporting porin activity
LEO80_21240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEO80_21255	COG3118	belongs to the thioredoxin family
LEO80_21260	COG0513	Belongs to the DEAD box helicase family
LEO80_21265	COG0248	Ppx GppA phosphatase
LEO80_21275	COG0742	ribosomal rna small subunit methyltransferase
LEO80_21295	COG0084	hydrolase, TatD family'
LEO80_21300	COG0805	protein transport
LEO80_21305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO80_21310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO80_21315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEO80_21320	COG3165	ubiquinone biosynthetic process from chorismate
LEO80_21330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEO80_21370	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LEO80_21375	COG0848	biopolymer transport protein
LEO80_21380	COG0811	peptide transport
LEO80_21385	COG0811	peptide transport
LEO80_21395	COG2771	luxR family
LEO80_21400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEO80_21405	COG1349	DNA-binding transcription factor activity
LEO80_21410	COG0745	RESPONSE REGULATOR receiver
LEO80_21415	COG2205	protein histidine kinase activity
LEO80_21425	COG4452	Inner membrane protein CreD
LEO80_21430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO80_21435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEO80_21440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEO80_21445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEO80_21450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEO80_21455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEO80_21460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEO80_21470	COG0356	it plays a direct role in the translocation of protons across the membrane
LEO80_21480	COG1475	DNA binding
LEO80_21485	COG1192	Involved in chromosome partitioning
LEO80_21490	COG0357	Ribosomal RNA small subunit methyltransferase G
LEO80_21495	COG0445	tRNA wobble uridine modification
LEO80_21500	COG0716	FMN binding
LEO80_21505	COG4774	siderophore transport
LEO80_21510	COG4615	Cyclic peptide transporter
LEO80_21515	COG1120	ATPase activity
LEO80_21520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO80_21530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEO80_21535	COG0706	membrane insertase activity
LEO80_21540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEO80_21545	COG0594	ribonuclease P activity
LEO80_21550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LEO80_21555	COG1126	abc transporter atp-binding protein