locus-tag	class	description
VI35_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VI35_00010	COG0592	DNA-directed DNA polymerase activity
VI35_00020	COG0187	DNA topoisomerase II activity
VI35_00025	COG2207	Transcriptional regulator
VI35_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VI35_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
VI35_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
VI35_00045	COG3977	Valine--pyruvate aminotransferase
VI35_00060	COG2814	Major facilitator Superfamily
VI35_00065	COG0745	RESPONSE REGULATOR receiver
VI35_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VI35_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_00115	COG1309	transcriptional regulator
VI35_00145	COG0561	phosphatase activity
VI35_00150	COG2267	carboxylic ester hydrolase activity
VI35_00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VI35_00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VI35_00165	COG1758	RNA polymerase activity
VI35_00185	COG3642	lipopolysaccharide core region biosynthetic process
VI35_00225	COG0589	response to stress
VI35_00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VI35_00240	COG3706	GGDEF domain
VI35_00245	COG1528	Iron-storage protein
VI35_00250	COG2081	HI0933 family
VI35_00255	COG2223	nitrite transmembrane transporter activity
VI35_00260	COG1280	lysine exporter protein (LysE YggA)
VI35_00275	COG3188	usher protein
VI35_00295	COG2205	protein histidine kinase activity
VI35_00295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_00305	COG3275	phosphorelay sensor kinase activity
VI35_00310	COG3279	Response regulator of the LytR AlgR family
VI35_00315	COG2223	nitrite transmembrane transporter activity
VI35_00320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VI35_00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VI35_00365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_00365	COG1042	CoA-binding domain protein
VI35_00365	COG0045	succinate-CoA ligase (ADP-forming) activity
VI35_00375	COG0583	DNA-binding transcription factor activity
VI35_00380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VI35_00385	COG0166	Belongs to the GPI family
VI35_00395	COG0668	transmembrane transport
VI35_00400	COG1309	transcriptional regulator
VI35_00405	COG0756	dUTP diphosphatase activity
VI35_00410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VI35_00415	COG2003	Belongs to the UPF0758 family
VI35_00420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VI35_00425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VI35_00435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VI35_00440	COG2990	Protein conserved in bacteria
VI35_00445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VI35_00450	COG0859	PFAM glycosyl transferase family 9
VI35_00455	COG0463	Glycosyl transferase, family 2
VI35_00460	COG0859	PFAM glycosyl transferase family 9
VI35_00465	COG1519	Transferase
VI35_00475	COG3171	Protein conserved in bacteria
VI35_00480	COG0732	type I restriction modification DNA specificity domain
VI35_00485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VI35_00490	COG3177	Filamentation induced by cAMP protein fic
VI35_00500	COG1715	Restriction endonuclease
VI35_00505	COG1561	YicC-like family, N-terminal region
VI35_00510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VI35_00515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VI35_00530	COG2203	Gaf domain
VI35_00530	COG5001	Diguanylate cyclase
VI35_00530	COG4251	negative regulation of phosphorylation
VI35_00530	COG3706	GGDEF domain
VI35_00535	COG3084	Protein conserved in bacteria
VI35_00545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VI35_00550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VI35_00560	COG1335	isochorismatase
VI35_00570	COG1683	Conserved Protein
VI35_00575	COG0204	Acyl-transferase
VI35_00580	COG0204	Acyl-transferase
VI35_00595	COG3978	acetolactate synthase activity
VI35_00600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VI35_00605	COG0129	dihydroxy-acid dehydratase activity
VI35_00625	COG1309	transcriptional regulator
VI35_00635	COG0254	rRNA binding
VI35_00645	COG0281	malic enzyme
VI35_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_00700	COG4310	Domain of unknown function (DUF2172)
VI35_00710	COG0366	Alpha amylase catalytic
VI35_00730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VI35_00735	COG3045	CreA protein
VI35_00750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VI35_00755	COG0174	glutamine synthetase
VI35_00775	COG3842	ATPase activity
VI35_00780	COG1176	ABC-type spermidine putrescine transport system, permease component I
VI35_00785	COG1177	transmembrane transport
VI35_00790	COG2258	MOSC domain
VI35_00805	COG2050	protein possibly involved in aromatic compounds catabolism
VI35_00810	COG0514	ATP-dependent DNA helicase (RecQ)
VI35_00820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VI35_00830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VI35_00835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VI35_00845	COG1648	precorrin-2 dehydrogenase activity
VI35_00845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_00850	COG2116	formate transmembrane transporter activity
VI35_00855	COG2146	nitrite reductase [NAD(P)H] activity
VI35_00860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VI35_00865	COG0842	Transport permease protein
VI35_00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_00900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VI35_00905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VI35_00930	COG1595	DNA-templated transcription, initiation
VI35_00935	COG3806	Anti-sigma factor
VI35_00940	COG1968	undecaprenyl-diphosphatase activity
VI35_00950	COG2017	converts alpha-aldose to the beta-anomer
VI35_00965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VI35_00970	COG1609	Transcriptional regulator
VI35_00975	COG3250	beta-galactosidase activity
VI35_01015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VI35_01025	COG1438	arginine binding
VI35_01035	COG0540	Belongs to the ATCase OTCase family
VI35_01070	COG3040	lipid binding
VI35_01080	COG1979	alcohol dehydrogenase
VI35_01085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VI35_01090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VI35_01095	COG2964	Protein conserved in bacteria
VI35_01100	COG3681	Belongs to the UPF0597 family
VI35_01105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_01110	COG0564	pseudouridine synthase activity
VI35_01125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VI35_01130	COG2502	aspartate--ammonia ligase
VI35_01135	COG1522	sequence-specific DNA binding
VI35_01145	COG0517	IMP dehydrogenase activity
VI35_01145	COG0516	GMP reductase activity
VI35_01165	COG2205	protein histidine kinase activity
VI35_01175	COG2204	response regulator
VI35_01190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VI35_01210	COG0745	RESPONSE REGULATOR receiver
VI35_01230	COG3005	denitrification pathway
VI35_01235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VI35_01245	COG0569	domain protein
VI35_01250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VI35_01275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VI35_01285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VI35_01290	COG0250	Participates in transcription elongation, termination and antitermination
VI35_01295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VI35_01300	COG0081	regulation of translation
VI35_01305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VI35_01310	COG0222	ribosome binding
VI35_01315	COG0085	RNA polymerase activity
VI35_01320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VI35_01325	COG2964	Protein conserved in bacteria
VI35_01330	COG0251	oxidation-reduction process
VI35_01335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VI35_01345	COG2168	tRNA wobble position uridine thiolation
VI35_01350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VI35_01355	COG0049	tRNA binding
VI35_01360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VI35_01365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VI35_01370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VI35_01405	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
VI35_01410	COG2252	PERMEase
VI35_01415	COG2376	Dihydroxyacetone kinase
VI35_01420	COG1461	Dihydroxyacetone kinase
VI35_01435	COG0583	DNA-binding transcription factor activity
VI35_01440	COG2957	Belongs to the agmatine deiminase family
VI35_01455	COG2957	Belongs to the agmatine deiminase family
VI35_01465	COG0628	permease
VI35_01470	COG0494	nUDIX hydrolase
VI35_01490	COG0753	catalase activity
VI35_01495	COG0456	acetyltransferase
VI35_01525	COG3842	ATPase activity
VI35_01535	COG1175	transmembrane transport
VI35_01560	COG0583	DNA-binding transcription factor activity
VI35_01570	COG1741	Belongs to the pirin family
VI35_01575	COG2259	Doxx family
VI35_01590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VI35_01600	COG0346	lactoylglutathione lyase activity
VI35_01610	COG0004	ammonium transporteR
VI35_01615	COG0347	Belongs to the P(II) protein family
VI35_01640	COG0745	RESPONSE REGULATOR receiver
VI35_01645	COG2205	protein histidine kinase activity
VI35_01650	COG1278	Cold shock
VI35_01675	COG2197	response regulator
VI35_01685	COG3047	cAMP biosynthetic process
VI35_01715	COG3135	benzoate transporter
VI35_01720	COG1396	sequence-specific DNA binding
VI35_01750	COG2926	Belongs to the UPF0265 family
VI35_01760	COG3028	Belongs to the UPF0307 family
VI35_01765	COG0312	modulator of DNA gyrase
VI35_01770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VI35_01775	COG5007	Belongs to the BolA IbaG family
VI35_01785	COG2854	intermembrane phospholipid transfer
VI35_01790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VI35_01795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VI35_01800	COG1127	ABC transporter
VI35_01805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VI35_01805	COG0517	IMP dehydrogenase activity
VI35_01810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VI35_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VI35_01825	COG1137	ATPase activity
VI35_01830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VI35_01840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_01845	COG1660	Displays ATPase and GTPase activities
VI35_01850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_01870	COG3964	amidohydrolase
VI35_01900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VI35_01905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VI35_01920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VI35_01925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VI35_01930	COG0723	plastoquinol--plastocyanin reductase activity
VI35_01935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VI35_01945	COG0625	glutathione transferase activity
VI35_01950	COG2969	positive regulation of protein catabolic process
VI35_01955	COG2823	Periplasmic or secreted lipoprotein
VI35_01960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VI35_01965	COG0792	nuclease activity
VI35_01970	COG3107	peptidoglycan biosynthetic process
VI35_01975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VI35_02000	COG1987	bacterial-type flagellum assembly
VI35_02020	COG2204	response regulator
VI35_02035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VI35_02065	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VI35_02070	COG1815	bacterial-type flagellum-dependent cell motility
VI35_02075	COG1558	bacterial-type flagellum-dependent cell motility
VI35_02080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VI35_02085	COG1749	Flagellar hook protein flgE
VI35_02095	COG4786	Flagellar basal body rod
VI35_02100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VI35_02105	COG1706	bacterial-type flagellum-dependent cell motility
VI35_02115	COG4786	Flagellar basal body rod
VI35_02115	COG1256	bacterial-type flagellum assembly
VI35_02140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_02145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_02150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VI35_02175	COG1191	sigma factor activity
VI35_02180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_02185	COG1360	Flagellar Motor Protein
VI35_02195	COG1388	LysM domain
VI35_02195	COG0741	lytic transglycosylase activity
VI35_02205	COG2001	Belongs to the MraZ family
VI35_02215	COG3116	cell division
VI35_02220	COG0768	penicillin binding
VI35_02225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VI35_02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VI35_02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VI35_02245	COG0772	Belongs to the SEDS family
VI35_02250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VI35_02255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VI35_02265	COG0849	cell division
VI35_02270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VI35_02275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VI35_02285	COG0653	protein targeting
VI35_02295	COG0494	nUDIX hydrolase
VI35_02300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VI35_02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VI35_02320	COG1459	type II secretion system
VI35_02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VI35_02360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VI35_02365	COG0508	dehydrogenase complex catalyzes the overall conversion of
VI35_02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VI35_02380	COG0840	transmembrane signaling receptor activity
VI35_02385	COG0840	transmembrane signaling receptor activity
VI35_02390	COG1752	Esterase of the alpha-beta hydrolase superfamily
VI35_02395	COG1049	propionate catabolic process, 2-methylcitrate cycle
VI35_02400	COG2200	EAL domain
VI35_02410	COG1280	lysine exporter protein (LysE YggA)
VI35_02420	COG0523	cobalamin synthesis protein
VI35_02425	COG0477	Major facilitator Superfamily
VI35_02440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VI35_02445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VI35_02495	COG1522	sequence-specific DNA binding
VI35_02500	COG0110	maltose O-acetyltransferase activity
VI35_02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_02510	COG1263	PTS System
VI35_02530	COG0252	asparaginase activity
VI35_02545	COG1803	Methylglyoxal synthase
VI35_02565	COG1444	tRNA N-acetyltransferase activity
VI35_02570	COG1565	acr, cog1565
VI35_02570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VI35_02580	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VI35_02610	COG0109	protoheme IX farnesyltransferase activity
VI35_02620	COG1177	transmembrane transport
VI35_02625	COG1176	ABC-type spermidine putrescine transport system, permease component I
VI35_02630	COG3842	ATPase activity
VI35_02640	COG0583	DNA-binding transcription factor activity
VI35_02685	COG0297	glycogen (starch) synthase activity
VI35_02690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VI35_02700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VI35_02710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_02720	COG2995	paraquat-inducible protein a
VI35_02725	COG3008	intermembrane lipid transfer
VI35_02725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VI35_02730	COG3009	Protein conserved in bacteria
VI35_02740	COG3240	lipase activity
VI35_02755	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VI35_02760	COG1194	a g-specific adenine glycosylase
VI35_02770	COG3267	Type II secretory pathway component ExeA
VI35_02770	COG3409	Peptidoglycan-binding domain 1 protein
VI35_02775	COG0617	tRNA 3'-terminal CCA addition
VI35_02780	COG0306	phosphate transporter
VI35_02785	COG1392	Phosphate transport regulator
VI35_02795	COG3133	Outer membrane lipoprotein
VI35_02800	COG0456	acetyltransferase
VI35_02815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VI35_02820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VI35_02830	COG3031	protein transport across the cell outer membrane
VI35_02840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VI35_02845	COG1459	type II secretion system
VI35_02850	COG2165	general secretion pathway protein
VI35_02860	COG2165	general secretion pathway protein
VI35_02865	COG4795	General secretion pathway protein
VI35_02880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VI35_02895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VI35_02905	COG1902	pentaerythritol trinitrate reductase activity
VI35_02910	COG1011	Hydrolase
VI35_02915	COG0494	nUDIX hydrolase
VI35_02920	COG1218	3'(2'),5'-bisphosphate nucleotidase
VI35_02930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_02945	COG0626	cystathionine gamma-synthase activity
VI35_02950	COG0460	homoserine dehydrogenase
VI35_02950	COG0527	aspartate kinase activity
VI35_02955	COG1346	cytolysis
VI35_02960	COG1380	Effector of murein hydrolase LrgA
VI35_02965	COG0583	DNA-binding transcription factor activity
VI35_03005	COG5002	protein histidine kinase activity
VI35_03005	COG5001	Diguanylate cyclase
VI35_03005	COG3447	MASE1 domain protein
VI35_03010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VI35_03020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VI35_03025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VI35_03035	COG0137	argininosuccinate synthase activity
VI35_03040	COG0165	Argininosuccinate lyase
VI35_03045	COG0583	DNA-binding transcription factor activity
VI35_03055	COG1942	4-Oxalocrotonate Tautomerase
VI35_03085	COG5492	domain, Protein
VI35_03085	COG4932	domain protein
VI35_03100	COG0110	maltose O-acetyltransferase activity
VI35_03105	COG3174	membrane
VI35_03110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_03115	COG1126	abc transporter atp-binding protein
VI35_03120	COG0765	amino acid transport
VI35_03125	COG0765	amino acid transport
VI35_03130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VI35_03150	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_03170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VI35_03175	COG4991	sh3 domain protein
VI35_03180	COG2816	NAD+ diphosphatase activity
VI35_03185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VI35_03190	COG1940	carbohydrate kinase activity
VI35_03200	COG0126	phosphoglycerate kinase activity
VI35_03210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_03240	COG0583	DNA-binding transcription factor activity
VI35_03245	COG0354	folic acid binding
VI35_03250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VI35_03260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VI35_03265	COG1595	DNA-templated transcription, initiation
VI35_03270	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VI35_03285	COG0481	GTPase activity
VI35_03290	COG0681	Belongs to the peptidase S26 family
VI35_03295	COG0571	ribonuclease III activity
VI35_03305	COG1381	Involved in DNA repair and RecF pathway recombination
VI35_03310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VI35_03320	COG4807	Protein conserved in bacteria
VI35_03330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_03335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VI35_03340	COG3956	TIGRFAM MazG family protein
VI35_03345	COG0504	CTP synthase activity
VI35_03350	COG0148	phosphopyruvate hydratase activity
VI35_03355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VI35_03360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VI35_03370	COG0585	pseudouridine synthase activity
VI35_03380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VI35_03385	COG1238	metal cluster binding
VI35_03390	COG4942	peptidase
VI35_03390	COG1388	LysM domain
VI35_03400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VI35_03405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VI35_03410	COG1610	YqeY-like protein
VI35_03415	COG0358	DNA primase activity
VI35_03420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VI35_03455	COG0138	bifunctional purine biosynthesis protein purh
VI35_03470	COG3036	rescue of stalled ribosome
VI35_03480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VI35_03495	COG0673	inositol 2-dehydrogenase activity
VI35_03505	COG1585	Membrane protein implicated in regulation of membrane protease activity
VI35_03510	COG0330	HflC and HflK could
VI35_03515	COG1648	precorrin-2 dehydrogenase activity
VI35_03515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_03520	COG0175	sulfate reduction
VI35_03525	COG2895	sulfate adenylyltransferase (ATP) activity
VI35_03530	COG3273	potassium ion transport
VI35_03530	COG0471	metal ion transport
VI35_03535	COG0529	Catalyzes the synthesis of activated sulfate
VI35_03565	COG1136	(ABC) transporter
VI35_03580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VI35_03595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VI35_03600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VI35_03605	COG0163	prenyltransferase activity
VI35_03620	COG1131	(ABC) transporter
VI35_03625	COG0842	Transport permease protein
VI35_03640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VI35_03660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VI35_03675	COG1643	Atp-dependent helicase
VI35_03685	COG0346	lactoylglutathione lyase activity
VI35_03695	COG2076	Multidrug Resistance protein
VI35_03725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VI35_03765	COG1280	lysine exporter protein (LysE YggA)
VI35_03770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VI35_03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_03815	COG0745	RESPONSE REGULATOR receiver
VI35_03820	COG3104	oligopeptide transport
VI35_03825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VI35_03830	COG1555	photosystem II stabilization
VI35_03840	COG2350	Protein conserved in bacteria
VI35_03845	COG2917	probably involved in intracellular septation
VI35_03850	COG0076	glutamate decarboxylase activity
VI35_03855	COG1272	protein, Hemolysin III
VI35_03860	COG2985	domain, Protein
VI35_03860	COG0569	domain protein
VI35_03950	COG0477	Major facilitator Superfamily
VI35_03955	COG0583	DNA-binding transcription factor activity
VI35_03960	COG3227	Zinc metalloprotease (Elastase)
VI35_03965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_03970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_03980	COG2731	YhcH YjgK YiaL family protein
VI35_03990	COG0668	transmembrane transport
VI35_04000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VI35_04010	COG0789	Transcriptional regulator
VI35_04045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VI35_04055	COG0488	(ABC) transporter
VI35_04060	COG0517	IMP dehydrogenase activity
VI35_04060	COG0516	GMP reductase activity
VI35_04070	COG0784	Response regulator, receiver
VI35_04070	COG0835	chemotaxis
VI35_04080	COG4181	ATPase activity
VI35_04100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_04105	COG4935	Belongs to the peptidase S8 family
VI35_04105	COG2234	aminopeptidase activity
VI35_04110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VI35_04115	COG3171	Protein conserved in bacteria
VI35_04120	COG2066	Belongs to the glutaminase family
VI35_04130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_04170	COG1132	(ABC) transporter
VI35_04200	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
VI35_04205	COG5001	Diguanylate cyclase
VI35_04205	COG3300	MHYT domain
VI35_04225	COG4628	conserved protein (DUF2132)
VI35_04235	COG1162	GTPase activity
VI35_04240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VI35_04280	COG1278	Cold shock
VI35_04290	COG0840	transmembrane signaling receptor activity
VI35_04295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_04300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_04305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_04355	COG0848	biopolymer transport protein
VI35_04360	COG0811	peptide transport
VI35_04365	COG0811	peptide transport
VI35_04380	COG4174	ABC transporter (Permease)
VI35_04385	COG4239	(ABC) transporter, permease
VI35_04395	COG0444	Belongs to the ABC transporter superfamily
VI35_04400	COG4608	Belongs to the ABC transporter superfamily
VI35_04410	COG2195	Cleaves the N-terminal amino acid of tripeptides
VI35_04420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VI35_04440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VI35_04465	COG0243	molybdopterin cofactor binding
VI35_04470	COG1648	precorrin-2 dehydrogenase activity
VI35_04470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VI35_04500	COG2146	nitrite reductase [NAD(P)H] activity
VI35_04500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VI35_04505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_04510	COG2313	pseudouridylate synthase activity
VI35_04530	COG0521	Mo-molybdopterin cofactor biosynthetic process
VI35_04540	COG2966	Psort location CytoplasmicMembrane, score
VI35_04545	COG3610	response to peptide
VI35_04555	COG4175	Glycine betaine
VI35_04560	COG4176	ABC-type proline glycine betaine transport system permease component
VI35_04565	COG2113	Glycine betaine
VI35_04570	COG0175	sulfate reduction
VI35_04580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VI35_04590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VI35_04605	COG0786	glutamate:sodium symporter activity
VI35_04610	COG0252	asparaginase activity
VI35_04615	COG3139	Protein of unknown function (DUF1315)
VI35_04635	COG0616	signal peptide processing
VI35_04640	COG1902	pentaerythritol trinitrate reductase activity
VI35_04640	COG0446	pyridine nucleotide-disulphide oxidoreductase
VI35_04645	COG0778	Nitroreductase
VI35_04660	COG2264	protein methyltransferase activity
VI35_04665	COG0604	alcohol dehydrogenase
VI35_04670	COG0583	DNA-binding transcription factor activity
VI35_04685	COG3924	membrane
VI35_04690	COG0439	Biotin carboxylase
VI35_04695	COG0511	ligase activity, forming carbon-carbon bonds
VI35_04700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VI35_04705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VI35_04720	COG3381	protein complex oligomerization
VI35_04730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VI35_04740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VI35_04745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VI35_04745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VI35_04760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VI35_04765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_04775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VI35_04780	COG4172	Belongs to the ABC transporter superfamily
VI35_04800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VI35_04805	COG0142	geranyltranstransferase activity
VI35_04815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_04825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VI35_04835	COG1534	Rna-binding protein
VI35_04840	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VI35_04845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VI35_04850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VI35_04855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VI35_04860	COG0149	triose-phosphate isomerase activity
VI35_04865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VI35_04880	COG0779	Required for maturation of 30S ribosomal subunits
VI35_04885	COG0195	Participates in both transcription termination and antitermination
VI35_04890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VI35_04895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VI35_04900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VI35_04905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VI35_04910	COG1185	polyribonucleotide nucleotidyltransferase activity
VI35_04915	COG2211	Major facilitator Superfamily
VI35_04920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VI35_04925	COG1422	Protein of unknown function (DUF1090)
VI35_04935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_04955	COG0312	modulator of DNA gyrase
VI35_04960	COG0312	modulator of DNA gyrase
VI35_04965	COG0312	modulator of DNA gyrase
VI35_04970	COG0716	FMN binding
VI35_04975	COG4974	Belongs to the 'phage' integrase family
VI35_04980	COG1970	mechanosensitive ion channel activity
VI35_04995	COG0789	Transcriptional regulator
VI35_05010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_05020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VI35_05030	COG0321	lipoyl(octanoyl) transferase activity
VI35_05035	COG2921	Belongs to the UPF0250 family
VI35_05040	COG1686	Belongs to the peptidase S11 family
VI35_05045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VI35_05050	COG2951	lytic endotransglycosylase activity
VI35_05055	COG0772	Belongs to the SEDS family
VI35_05060	COG0768	penicillin binding
VI35_05065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VI35_05070	COG0799	negative regulation of ribosome biogenesis
VI35_05075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VI35_05095	COG0495	leucyl-tRNA aminoacylation
VI35_05100	COG2888	peptidyl-tyrosine sulfation
VI35_05105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VI35_05110	COG4535	Mg2 and Co2 transporter CorC
VI35_05120	COG1702	phosphate starvation-inducible protein PhoH
VI35_05125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VI35_05130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_05135	COG1335	isochorismatase
VI35_05175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VI35_05190	COG1464	Belongs to the NlpA lipoprotein family
VI35_05195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VI35_05205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VI35_05215	COG0516	GMP reductase activity
VI35_05230	COG0745	RESPONSE REGULATOR receiver
VI35_05240	COG0300	oxidoreductase activity
VI35_05280	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VI35_05285	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VI35_05290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VI35_05295	COG1053	succinate dehydrogenase
VI35_05305	COG0584	glycerophosphoryl diester phosphodiesterase
VI35_05335	COG0583	DNA-binding transcription factor activity
VI35_05350	COG0583	DNA-binding transcription factor activity
VI35_05355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VI35_05385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VI35_05390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VI35_05400	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VI35_05405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VI35_05410	COG0546	phosphoglycolate phosphatase activity
VI35_05415	COG0180	Tryptophanyl-tRNA synthetase
VI35_05430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VI35_05440	COG1012	belongs to the aldehyde dehydrogenase family
VI35_05455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_05465	COG0674	pyruvate-flavodoxin oxidoreductase activity
VI35_05465	COG1013	pyruvate-flavodoxin oxidoreductase activity
VI35_05465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VI35_05465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_05500	COG0490	domain, Protein
VI35_05500	COG0471	metal ion transport
VI35_05545	COG0012	GTP binding
VI35_05550	COG0193	aminoacyl-tRNA hydrolase activity
VI35_05555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VI35_05565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VI35_05570	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VI35_05575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VI35_05580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VI35_05595	COG2912	Transglutaminase-like superfamily
VI35_05600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VI35_05605	COG1301	dicarboxylic acid transport
VI35_05615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VI35_05630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VI35_05635	COG1115	amino acid carrier protein
VI35_05655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VI35_05665	COG0189	ligase activity
VI35_05670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VI35_05680	COG3091	SprT-like family
VI35_05690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VI35_05700	COG2801	Transposase and inactivated derivatives
VI35_05720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VI35_05725	COG0739	heme binding
VI35_05730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VI35_05740	COG1881	PFAM PEBP family protein
VI35_05750	COG0583	DNA-binding transcription factor activity
VI35_05760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VI35_05770	COG0583	DNA-binding transcription factor activity
VI35_05775	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_05780	COG0616	signal peptide processing
VI35_05785	COG3724	N-succinylarginine dihydrolase activity
VI35_05790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VI35_05800	COG0840	transmembrane signaling receptor activity
VI35_05820	COG4608	Belongs to the ABC transporter superfamily
VI35_05825	COG0444	Belongs to the ABC transporter superfamily
VI35_05830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_05860	COG0798	PFAM Bile acid sodium symporter
VI35_05865	COG1393	Belongs to the ArsC family
VI35_05875	COG1677	Flagellar hook-basal body complex protein FliE
VI35_05885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VI35_05935	COG1987	bacterial-type flagellum assembly
VI35_05940	COG1684	flagellar biosynthetic protein fliR
VI35_05950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VI35_05960	COG0455	bacterial-type flagellum organization
VI35_05975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VI35_05980	COG0643	Histidine kinase
VI35_05980	COG2198	Histidine kinase
VI35_05985	COG2201	protein-glutamate methylesterase activity
VI35_05990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_05995	COG1360	Flagellar Motor Protein
VI35_06000	COG1192	Involved in chromosome partitioning
VI35_06010	COG0835	chemotaxis
VI35_06030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VI35_06035	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VI35_06040	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VI35_06085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VI35_06090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_06090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_06105	COG0259	pyridoxamine-phosphate oxidase activity
VI35_06135	COG3153	acetyltransferase
VI35_06150	COG0800	Aldolase
VI35_06155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_06170	COG0246	Mannitol dehydrogenase
VI35_06205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VI35_06210	COG2867	negative regulation of translational initiation
VI35_06220	COG0702	epimerase
VI35_06225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_06230	COG1454	alcohol dehydrogenase
VI35_06240	COG0564	pseudouridine synthase activity
VI35_06245	COG1957	nucleoside hydrolase
VI35_06270	COG1280	lysine exporter protein (LysE YggA)
VI35_06290	COG1876	peptidase activity
VI35_06295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VI35_06300	COG1393	Belongs to the ArsC family
VI35_06320	COG3069	C4-dicarboxylate transmembrane transporter activity
VI35_06325	COG1473	amidohydrolase
VI35_06335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VI35_06340	COG0017	Asparaginyl-tRNA synthetase
VI35_06360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VI35_06370	COG2226	methyltransferase
VI35_06370	COG1073	alpha beta
VI35_06375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VI35_06380	COG0501	Belongs to the peptidase M48B family
VI35_06400	COG2841	Protein conserved in bacteria
VI35_06410	COG0534	Mate efflux family protein
VI35_06435	COG1454	alcohol dehydrogenase
VI35_06445	COG1309	transcriptional regulator
VI35_06460	COG0791	NLP P60 protein
VI35_06465	COG0583	DNA-binding transcription factor activity
VI35_06485	COG0500	methyltransferase
VI35_06490	COG4106	trans-aconitate 2-methyltransferase activity
VI35_06495	COG1801	Protein of unknown function DUF72
VI35_06505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VI35_06510	COG0217	transcriptional regulatory protein
VI35_06515	COG2194	sulfuric ester hydrolase activity
VI35_06520	COG1940	carbohydrate kinase activity
VI35_06520	COG1846	Transcriptional regulator
VI35_06525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VI35_06530	COG0363	glucosamine-6-phosphate deaminase activity
VI35_06535	COG1263	PTS System
VI35_06535	COG2190	(PTS) system
VI35_06535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_06545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_06550	COG0735	belongs to the Fur family
VI35_06560	COG0716	FMN binding
VI35_06580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VI35_06585	COG0033	Phosphoglucomutase
VI35_06595	COG1846	Transcriptional regulator
VI35_06600	COG2951	lytic endotransglycosylase activity
VI35_06605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VI35_06630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VI35_06640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VI35_06675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VI35_06700	COG1607	acyl-coa hydrolase
VI35_06715	COG1388	LysM domain
VI35_06715	COG0741	lytic transglycosylase activity
VI35_06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VI35_06725	COG2226	methyltransferase
VI35_06730	COG0328	RNA-DNA hybrid ribonuclease activity
VI35_06735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_06745	COG0784	Response regulator, receiver
VI35_06745	COG3437	response regulator, receiver
VI35_06750	COG1960	acyl-CoA dehydrogenase activity
VI35_06755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VI35_06760	COG0121	glutamine amidotransferase
VI35_06770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VI35_06780	COG2205	protein histidine kinase activity
VI35_06780	COG0784	Response regulator, receiver
VI35_06795	COG2197	response regulator
VI35_06800	COG3850	Histidine kinase
VI35_06810	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_06810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_06820	COG0243	molybdopterin cofactor binding
VI35_06825	COG0437	4 iron, 4 sulfur cluster binding
VI35_06840	COG3005	denitrification pathway
VI35_06845	COG0521	Mo-molybdopterin cofactor biosynthetic process
VI35_06850	COG0315	cyclic pyranopterin monophosphate synthase activity
VI35_06855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VI35_06860	COG0314	molybdopterin synthase activity
VI35_06880	COG2267	carboxylic ester hydrolase activity
VI35_06895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VI35_06905	COG0302	gtp cyclohydrolase
VI35_06910	COG0840	transmembrane signaling receptor activity
VI35_06915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VI35_06925	COG0583	DNA-binding transcription factor activity
VI35_06955	COG2195	Cleaves the N-terminal amino acid of tripeptides
VI35_06965	COG1166	arginine decarboxylase activity
VI35_06995	COG4191	Histidine kinase
VI35_07015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VI35_07035	COG0583	DNA-binding transcription factor activity
VI35_07065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_07075	COG1294	oxidase, subunit
VI35_07085	COG2814	Major facilitator Superfamily
VI35_07090	COG0656	L-ascorbic acid biosynthetic process
VI35_07110	COG0583	DNA-binding transcription factor activity
VI35_07115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VI35_07120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VI35_07125	COG2271	Major facilitator Superfamily
VI35_07130	COG1349	DNA-binding transcription factor activity
VI35_07145	COG0584	glycerophosphoryl diester phosphodiesterase
VI35_07150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_07155	COG1605	Chorismate mutase
VI35_07155	COG0287	Prephenate dehydrogenase
VI35_07165	COG3085	chromosome segregation
VI35_07170	COG4574	serine-type endopeptidase inhibitor activity
VI35_07195	COG4771	TonB-dependent receptor
VI35_07200	COG3083	sulfuric ester hydrolase activity
VI35_07205	COG3082	Protein of unknown function (DUF1414)
VI35_07220	COG1175	transmembrane transport
VI35_07255	COG0425	Belongs to the sulfur carrier protein TusA family
VI35_07260	COG4783	chaperone-mediated protein folding
VI35_07270	COG1393	Belongs to the ArsC family
VI35_07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_07315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_07320	COG4215	(ABC) transporter
VI35_07325	COG4160	amino acid transport
VI35_07335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VI35_07360	COG1566	PFAM secretion protein HlyD family protein
VI35_07370	COG0628	permease
VI35_07380	COG4953	penicillin-binding protein 1C
VI35_07390	COG0301	tRNA thio-modification
VI35_07390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_07405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_07410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_07445	COG2089	acid synthase
VI35_07465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
VI35_07475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VI35_07480	COG1086	Polysaccharide biosynthesis protein
VI35_07485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VI35_07495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VI35_07520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VI35_07530	COG4659	FMN binding
VI35_07535	COG4658	electron transport chain
VI35_07545	COG2878	Part of a membrane complex involved in electron transport
VI35_07550	COG4657	Part of a membrane complex involved in electron transport
VI35_07555	COG0697	spore germination
VI35_07580	COG1288	antiporter activity
VI35_07585	COG0436	Aminotransferase
VI35_07595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VI35_07600	COG2027	D-alanyl-D-alanine carboxypeptidase
VI35_07610	COG1566	PFAM secretion protein HlyD family protein
VI35_07625	COG1966	Carbon starvation protein
VI35_07630	COG3279	Response regulator of the LytR AlgR family
VI35_07635	COG3275	phosphorelay sensor kinase activity
VI35_07650	COG2095	MarC family integral membrane protein
VI35_07660	COG0601	transmembrane transport
VI35_07665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_07670	COG0444	Belongs to the ABC transporter superfamily
VI35_07680	COG0861	Integral membrane protein TerC family
VI35_07685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VI35_07695	COG1301	dicarboxylic acid transport
VI35_07710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VI35_07715	COG0582	viral genome integration into host DNA
VI35_07765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_07785	COG1396	sequence-specific DNA binding
VI35_07850	COG1403	HNH endonuclease
VI35_07895	COG2801	Transposase and inactivated derivatives
VI35_08000	COG2801	Transposase and inactivated derivatives
VI35_08025	COG0537	adenosine 5'-monophosphoramidase activity
VI35_08065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_08090	COG1164	Oligoendopeptidase f
VI35_08100	COG1252	NADH dehydrogenase
VI35_08105	COG0393	Putative heavy-metal-binding
VI35_08110	COG1619	proteins homologs of microcin C7 resistance protein MccF
VI35_08125	COG0527	aspartate kinase activity
VI35_08130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VI35_08130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VI35_08135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VI35_08170	COG0247	lactate metabolic process
VI35_08175	COG1139	Iron-sulfur cluster binding protein
VI35_08210	COG1136	(ABC) transporter
VI35_08255	COG0672	)-iron permease
VI35_08330	COG3501	Rhs element vgr protein
VI35_08340	COG3209	COG3209 Rhs family protein
VI35_08355	COG3209	COG3209 Rhs family protein
VI35_08485	COG3501	Rhs element vgr protein
VI35_08515	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
VI35_08520	COG0437	4 iron, 4 sulfur cluster binding
VI35_08525	COG5557	Pfam Polysulphide reductase, NrfD
VI35_08535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VI35_08540	COG1773	rubredoxin
VI35_08545	COG0747	negative chemotaxis
VI35_08550	COG0601	transmembrane transport
VI35_08565	COG1124	(ABC) transporter
VI35_08580	COG0375	protein maturation
VI35_08595	COG0298	carbon dioxide binding
VI35_08600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VI35_08605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VI35_08615	COG0326	Molecular chaperone. Has ATPase activity
VI35_08620	COG0563	adenylate kinase activity
VI35_08625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VI35_08630	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VI35_08640	COG0840	transmembrane signaling receptor activity
VI35_08680	COG1021	2,3-dihydroxybenzoate-AMP ligase
VI35_08685	COG1535	isochorismatase
VI35_08685	COG3433	isochorismatase activity
VI35_08695	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_08705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VI35_08720	COG1120	ATPase activity
VI35_08725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_08730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_08735	COG4771	TonB-dependent receptor
VI35_08780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VI35_08790	COG0861	Integral membrane protein TerC family
VI35_08805	COG1022	Amp-dependent synthetase and ligase
VI35_08810	COG0295	cytidine deaminase activity
VI35_08815	COG1346	cytolysis
VI35_08820	COG1380	Effector of murein hydrolase LrgA
VI35_08835	COG2925	Exonuclease
VI35_08840	COG0582	viral genome integration into host DNA
VI35_08900	COG1846	Transcriptional regulator
VI35_08945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VI35_08950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VI35_08955	COG2135	peptidase activity
VI35_08985	COG4220	transposase activity
VI35_09005	COG0740	serine-type endopeptidase activity
VI35_09115	COG0667	Aldo Keto reductase
VI35_09125	COG4221	oxidoreductase activity
VI35_09130	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_09135	COG3321	synthase
VI35_09135	COG0604	alcohol dehydrogenase
VI35_09140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_09160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VI35_09165	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_09200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VI35_09205	COG1085	galactose-1-phosphate uridylyltransferase
VI35_09220	COG4580	involved in the transport of maltose and maltodextrins
VI35_09245	COG2182	Extracellular solute-binding protein
VI35_09250	COG1175	transmembrane transport
VI35_09255	COG3833	ABC-type maltose transport systems, permease component
VI35_09260	COG3867	Arabinogalactan endo-beta-1,4-galactanase
VI35_09265	COG1874	Beta-galactosidase
VI35_09270	COG1263	PTS System
VI35_09270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_09300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VI35_09320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VI35_09325	COG0436	Aminotransferase
VI35_09345	COG1069	ribulokinase activity
VI35_09350	COG1879	ABC-type sugar transport system periplasmic component
VI35_09360	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_09370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VI35_09390	COG1451	nucleotide metabolic process
VI35_09405	COG3069	C4-dicarboxylate transmembrane transporter activity
VI35_09415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VI35_09415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_09420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VI35_09440	COG2009	succinate dehydrogenase
VI35_09445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VI35_09460	COG0567	Dehydrogenase, E1 component
VI35_09465	COG0508	dehydrogenase complex catalyzes the overall conversion of
VI35_09475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VI35_09495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_09505	COG3842	ATPase activity
VI35_09510	COG1840	ABC-type Fe3 transport system, periplasmic component
VI35_09520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VI35_09530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_09535	COG1882	Formate acetyltransferase
VI35_09540	COG2116	formate transmembrane transporter activity
VI35_09560	COG2076	Multidrug Resistance protein
VI35_09565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VI35_09570	COG1278	Cold shock
VI35_09575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VI35_09580	COG0542	response to heat
VI35_09585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VI35_09595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VI35_09600	COG3134	Outer membrane lipoprotein
VI35_09605	COG3706	GGDEF domain
VI35_09610	COG0492	ferredoxin-NADP+ reductase activity
VI35_09615	COG0686	Belongs to the AlaDH PNT family
VI35_09630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VI35_09640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VI35_09645	COG1286	toxin biosynthetic process
VI35_09650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VI35_09655	COG2723	6-phospho-beta-galactosidase activity
VI35_09660	COG1263	PTS System
VI35_09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_09665	COG1609	Transcriptional regulator
VI35_09675	COG4172	Belongs to the ABC transporter superfamily
VI35_09685	COG4171	peptide transport system, permease
VI35_09705	COG1842	Phage shock protein A
VI35_09720	COG3106	COG3106 Predicted ATPase
VI35_09725	COG3768	UPF0283 membrane protein
VI35_09735	COG2154	pterin-4-alpha-carbinolamine dehydratase
VI35_09755	COG2885	chlorophyll binding
VI35_09765	COG1570	exodeoxyribonuclease VII activity
VI35_09775	COG0366	Alpha amylase catalytic
VI35_09775	COG1874	Beta-galactosidase
VI35_09785	COG0516	GMP reductase activity
VI35_09785	COG0517	IMP dehydrogenase activity
VI35_09790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VI35_09790	COG0519	Catalyzes the synthesis of GMP from XMP
VI35_09820	COG1846	Transcriptional regulator
VI35_09840	COG2062	phosphohistidine phosphatase, SixA
VI35_09850	COG0697	spore germination
VI35_09860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VI35_09865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VI35_09875	COG4591	ABC-type transport system involved in lipoprotein release permease component
VI35_09880	COG1136	(ABC) transporter
VI35_09885	COG4591	ABC-type transport system involved in lipoprotein release permease component
VI35_09890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VI35_09905	COG0544	peptidyl-prolyl cis-trans isomerase activity
VI35_09910	COG0740	serine-type endopeptidase activity
VI35_09915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VI35_09920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VI35_09925	COG0776	regulation of translation
VI35_09930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VI35_09935	COG0488	(ABC) transporter
VI35_09940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VI35_09945	COG3162	membrane
VI35_09965	COG1115	amino acid carrier protein
VI35_09975	COG3228	Belongs to the MtfA family
VI35_09980	COG1584	GPR1 FUN34 yaaH family protein
VI35_10005	COG1024	Enoyl-CoA hydratase
VI35_10015	COG1960	acyl-CoA dehydrogenase activity
VI35_10025	COG1960	acyl-CoA dehydrogenase activity
VI35_10035	COG1024	Enoyl-CoA hydratase
VI35_10055	COG0730	response to heat
VI35_10070	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_10080	COG1129	ABC transporter
VI35_10085	COG1879	ABC-type sugar transport system periplasmic component
VI35_10090	COG0583	DNA-binding transcription factor activity
VI35_10105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VI35_10110	COG0243	molybdopterin cofactor binding
VI35_10115	COG3706	GGDEF domain
VI35_10115	COG0745	RESPONSE REGULATOR receiver
VI35_10120	COG0583	DNA-binding transcription factor activity
VI35_10125	COG2723	6-phospho-beta-galactosidase activity
VI35_10135	COG0583	DNA-binding transcription factor activity
VI35_10150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VI35_10170	COG1560	Kdo2-lipid A biosynthetic process
VI35_10175	COG1560	Kdo2-lipid A biosynthetic process
VI35_10190	COG0417	DNA replication proofreading
VI35_10220	COG0534	Mate efflux family protein
VI35_10230	COG0307	riboflavin synthase, alpha
VI35_10245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_10255	COG0697	spore germination
VI35_10260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VI35_10320	COG2894	cell division
VI35_10330	COG3100	YcgL domain-containing protein
VI35_10335	COG2951	lytic endotransglycosylase activity
VI35_10340	COG1760	l-serine dehydratase
VI35_10350	COG1760	l-serine dehydratase
VI35_10355	COG3123	guanosine phosphorylase activity
VI35_10360	COG1301	dicarboxylic acid transport
VI35_10375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VI35_10380	COG2067	long-chain fatty acid transport protein
VI35_10385	COG2067	long-chain fatty acid transport protein
VI35_10425	COG0714	Associated with various cellular activities
VI35_10430	COG0183	Belongs to the thiolase family
VI35_10445	COG4681	YaeQ
VI35_10470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_10485	COG3134	Outer membrane lipoprotein
VI35_10495	COG0318	PFAM AMP-dependent synthetase and ligase
VI35_10500	COG2378	regulation of single-species biofilm formation
VI35_10510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VI35_10510	COG0140	phosphoribosyl-ATP diphosphatase activity
VI35_10530	COG3437	response regulator, receiver
VI35_10535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VI35_10540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VI35_10545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VI35_10545	COG0131	Imidazoleglycerol-phosphate dehydratase
VI35_10550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VI35_10555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VI35_10575	COG1214	PFAM Peptidase M22, glycoprotease
VI35_10590	COG0318	PFAM AMP-dependent synthetase and ligase
VI35_10605	COG0697	spore germination
VI35_10615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VI35_10620	COG2832	Protein of unknown function (DUF454)
VI35_10625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VI35_10635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VI35_10640	COG0583	DNA-binding transcription factor activity
VI35_10655	COG2197	response regulator
VI35_10665	COG1643	Atp-dependent helicase
VI35_10675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VI35_10685	COG3437	response regulator, receiver
VI35_10695	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VI35_10700	COG0709	Synthesizes selenophosphate from selenide and ATP
VI35_10715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VI35_10720	COG0840	transmembrane signaling receptor activity
VI35_10725	COG1254	Belongs to the acylphosphatase family
VI35_10735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_10735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_10740	COG0489	protein tyrosine kinase activity
VI35_10745	COG0572	uridine kinase
VI35_10750	COG0717	Belongs to the dCTP deaminase family
VI35_10760	COG1530	ribonuclease E activity
VI35_10765	COG0564	pseudouridine synthase activity
VI35_10780	COG1399	metal-binding, possibly nucleic acid-binding protein
VI35_10785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VI35_10790	COG0416	fatty acid biosynthetic process
VI35_10795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VI35_10805	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_10810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VI35_10820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VI35_10825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VI35_10830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VI35_10835	COG0470	DNA polymerase III
VI35_10840	COG0084	hydrolase, TatD family'
VI35_10855	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VI35_10855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_10865	COG2995	paraquat-inducible protein a
VI35_10885	COG1067	ATP-dependent peptidase activity
VI35_10890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VI35_10905	COG0488	(ABC) transporter
VI35_10915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VI35_10915	COG0116	Belongs to the methyltransferase superfamily
VI35_10925	COG0167	dihydroorotate dehydrogenase activity
VI35_10930	COG2902	Dehydrogenase
VI35_10940	COG0308	aminopeptidase N
VI35_10950	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VI35_10955	COG1956	GAF domain-containing protein
VI35_10965	COG3278	Belongs to the heme-copper respiratory oxidase family
VI35_10980	COG2010	Cytochrome c
VI35_11005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VI35_11010	COG0589	response to stress
VI35_11015	COG0037	tRNA processing
VI35_11030	COG0625	glutathione transferase activity
VI35_11035	COG1869	D-ribose catabolic process
VI35_11040	COG1129	ABC transporter
VI35_11045	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_11050	COG1879	ABC-type sugar transport system periplasmic component
VI35_11055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_11060	COG1609	Transcriptional regulator
VI35_11065	COG3300	MHYT domain
VI35_11065	COG5001	Diguanylate cyclase
VI35_11075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VI35_11100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_11100	COG0072	phenylalanine-tRNA ligase activity
VI35_11105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VI35_11110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VI35_11115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VI35_11120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VI35_11125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VI35_11160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_11165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_11175	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VI35_11180	COG3313	Fe-S protein
VI35_11185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VI35_11185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VI35_11185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VI35_11190	COG1105	Belongs to the carbohydrate kinase PfkB family
VI35_11200	COG1609	Transcriptional regulator
VI35_11205	COG0814	amino acid
VI35_11215	COG5654	RES domain protein
VI35_11220	COG0513	Belongs to the DEAD box helicase family
VI35_11230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VI35_11235	COG2890	protein-(glutamine-N5) methyltransferase activity
VI35_11275	COG2824	Alkylphosphonate utilization operon protein PhnA
VI35_11285	COG1280	lysine exporter protein (LysE YggA)
VI35_11330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VI35_11335	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VI35_11345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VI35_11350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VI35_11360	COG0205	6-phosphofructokinase activity
VI35_11370	COG1011	Hydrolase
VI35_11430	COG0583	DNA-binding transcription factor activity
VI35_11435	COG0730	response to heat
VI35_11445	COG1181	Belongs to the D-alanine--D-alanine ligase family
VI35_11455	COG0386	Belongs to the glutathione peroxidase family
VI35_11460	COG0513	Belongs to the DEAD box helicase family
VI35_11500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VI35_11525	COG3243	poly(R)-hydroxyalkanoic acid synthase
VI35_11535	COG2501	S4 domain
VI35_11595	COG0058	SHG alpha-glucan phosphorylase activity
VI35_11625	COG0814	amino acid
VI35_11630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VI35_11635	COG0514	ATP-dependent DNA helicase (RecQ)
VI35_11640	COG2766	serine protein kinase
VI35_11645	COG2718	Belongs to the UPF0229 family
VI35_11650	COG2719	SpoVR family
VI35_11655	COG2186	Transcriptional regulator
VI35_11660	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VI35_11665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VI35_11670	COG0586	Pfam SNARE associated Golgi protein
VI35_11695	COG0569	domain protein
VI35_11695	COG2985	domain, Protein
VI35_11700	COG0741	lytic transglycosylase activity
VI35_11700	COG1196	nuclear chromosome segregation
VI35_11700	COG0739	heme binding
VI35_11705	COG3181	Tripartite tricarboxylate transporter family receptor
VI35_11720	COG4565	transcriptional regulatory protein
VI35_11725	COG3290	protein histidine kinase activity
VI35_11735	COG0840	transmembrane signaling receptor activity
VI35_11740	COG3012	SEC-C Motif Domain Protein
VI35_11745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VI35_11750	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VI35_11755	COG0247	lactate metabolic process
VI35_11785	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VI35_11790	COG0437	4 iron, 4 sulfur cluster binding
VI35_11795	COG3301	Polysulphide reductase, NrfD
VI35_11825	COG3046	protein related to deoxyribodipyrimidine photolyase
VI35_11830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_11845	COG0517	IMP dehydrogenase activity
VI35_11845	COG0516	GMP reductase activity
VI35_11855	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VI35_11860	COG0583	DNA-binding transcription factor activity
VI35_11870	COG4774	siderophore transport
VI35_11875	COG3706	GGDEF domain
VI35_11880	COG3706	GGDEF domain
VI35_11880	COG5001	Diguanylate cyclase
VI35_11880	COG4251	negative regulation of phosphorylation
VI35_11880	COG2203	Gaf domain
VI35_11885	COG2200	EAL domain
VI35_11885	COG2771	luxR family
VI35_11900	COG2910	NAD(P)H-binding
VI35_11935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VI35_11955	COG2190	(PTS) system
VI35_11955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_11955	COG1263	PTS System
VI35_11960	COG1737	Transcriptional regulator
VI35_11985	COG1435	thymidine kinase activity
VI35_11995	COG2916	Histone family protein nucleoid-structuring protein H-NS
VI35_12000	COG2096	Adenosyltransferase
VI35_12005	COG3530	Putative quorum-sensing-regulated virulence factor
VI35_12010	COG0602	queuosine metabolic process
VI35_12015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VI35_12035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VI35_12045	COG0776	regulation of translation
VI35_12050	COG0539	negative regulation of cytoplasmic translation
VI35_12055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VI35_12060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VI35_12085	COG0778	Nitroreductase
VI35_12090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VI35_12095	COG5001	Diguanylate cyclase
VI35_12095	COG3300	MHYT domain
VI35_12105	COG0583	DNA-binding transcription factor activity
VI35_12110	COG0745	RESPONSE REGULATOR receiver
VI35_12135	COG4989	oxidoreductase activity
VI35_12140	COG0724	RNA recognition motif
VI35_12150	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VI35_12175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_12180	COG1360	Flagellar Motor Protein
VI35_12185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_12190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_12195	COG0649	NAD binding
VI35_12195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_12215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VI35_12220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_12225	COG0839	Belongs to the complex I subunit 6 family
VI35_12230	COG0713	ATP synthesis coupled electron transport
VI35_12240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_12245	COG1007	ATP synthesis coupled electron transport
VI35_12255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VI35_12265	COG1645	bacterial-type flagellum-dependent swarming motility
VI35_12270	COG1160	GTP binding
VI35_12275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_12280	COG2976	Protein conserved in bacteria
VI35_12285	COG0124	histidyl-tRNA synthetase
VI35_12295	COG1426	Protein conserved in bacteria
VI35_12305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VI35_12310	COG0105	UTP biosynthetic process
VI35_12325	COG0633	Ferredoxin
VI35_12330	COG0443	Heat shock 70 kDa protein
VI35_12335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VI35_12345	COG0822	iron-sulfur transferase activity
VI35_12350	COG1104	cysteine desulfurase activity
VI35_12385	COG2897	thiosulfate sulfurtransferase activity
VI35_12390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_12395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_12400	COG1862	Preprotein translocase
VI35_12410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VI35_12415	COG0517	IMP dehydrogenase activity
VI35_12420	COG0450	alkyl hydroperoxide reductase
VI35_12425	COG3634	alkyl hydroperoxide reductase activity
VI35_12460	COG0509	glycine decarboxylation via glycine cleavage system
VI35_12465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VI35_12470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_12475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_12495	COG2814	Major facilitator Superfamily
VI35_12505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_12510	COG0601	transmembrane transport
VI35_12520	COG0625	glutathione transferase activity
VI35_12525	COG0625	glutathione transferase activity
VI35_12545	COG3423	Transcriptional regulator
VI35_12570	COG0483	inositol monophosphate 1-phosphatase activity
VI35_12585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_12590	COG2056	Na+-H+ antiporter family
VI35_12595	COG2814	Major facilitator Superfamily
VI35_12600	COG0583	DNA-binding transcription factor activity
VI35_12605	COG5001	Diguanylate cyclase
VI35_12620	COG2050	protein possibly involved in aromatic compounds catabolism
VI35_12645	COG1253	flavin adenine dinucleotide binding
VI35_12650	COG1902	pentaerythritol trinitrate reductase activity
VI35_12660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VI35_12665	COG0647	UMP catabolic process
VI35_12675	COG0367	asparagine synthase
VI35_12685	COG0625	glutathione transferase activity
VI35_12695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VI35_12710	COG0564	pseudouridine synthase activity
VI35_12715	COG5001	Diguanylate cyclase
VI35_12725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VI35_12760	COG0670	Belongs to the BI1 family
VI35_12765	COG1289	transmembrane transporter activity
VI35_12770	COG2920	part of a sulfur-relay system
VI35_12775	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VI35_12790	COG0101	tRNA pseudouridine synthase activity
VI35_12800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VI35_12805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VI35_12815	COG1464	Belongs to the NlpA lipoprotein family
VI35_12850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VI35_12860	COG1113	amino acid transport
VI35_12865	COG0582	viral genome integration into host DNA
VI35_12920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VI35_12930	COG0596	Alpha beta hydrolase
VI35_13010	COG1242	4 iron, 4 sulfur cluster binding
VI35_13015	COG0069	glutamate synthase activity
VI35_13015	COG0070	glutamate synthase
VI35_13015	COG0067	glutamate synthase
VI35_13020	COG0493	'glutamate synthase
VI35_13030	COG0765	amino acid transport
VI35_13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_13060	COG4104	PAAR repeat-containing protein
VI35_13070	COG0513	Belongs to the DEAD box helicase family
VI35_13100	COG3706	GGDEF domain
VI35_13105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VI35_13115	COG0505	Belongs to the CarA family
VI35_13120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VI35_13140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VI35_13145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VI35_13150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_13185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VI35_13195	COG0023	Translation Initiation Factor
VI35_13200	COG2119	membrane
VI35_13260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VI35_13270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_13275	COG2261	transglycosylase associated protein
VI35_13280	COG1309	transcriptional regulator
VI35_13295	COG0402	S-adenosylhomocysteine deaminase activity
VI35_13300	COG0583	DNA-binding transcription factor activity
VI35_13325	COG0322	excinuclease ABC activity
VI35_13330	COG2197	response regulator
VI35_13335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VI35_13340	COG2835	tetraacyldisaccharide 4'-kinase activity
VI35_13350	COG1132	(ABC) transporter
VI35_13370	COG0433	COG0433 Predicted ATPase
VI35_13375	COG1448	Aminotransferase
VI35_13390	COG1199	ATP-dependent helicase activity
VI35_13405	COG0477	Major facilitator Superfamily
VI35_13415	COG1785	Belongs to the alkaline phosphatase family
VI35_13435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VI35_13445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_13450	COG0765	amino acid transport
VI35_13455	COG1126	abc transporter atp-binding protein
VI35_13465	COG0531	amino acid
VI35_13480	COG1253	flavin adenine dinucleotide binding
VI35_13485	COG0704	Plays a role in the regulation of phosphate uptake
VI35_13495	COG0581	inorganic phosphate transmembrane transporter activity
VI35_13505	COG0590	tRNA wobble adenosine to inosine editing
VI35_13540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VI35_13545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VI35_13550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VI35_13555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VI35_13565	COG3852	Histidine kinase
VI35_13570	COG2204	response regulator
VI35_13590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VI35_13595	COG0248	Ppx GppA phosphatase
VI35_13600	COG2239	Acts as a magnesium transporter
VI35_13615	COG3951	Flagellar rod assembly protein muramidase FlgJ
VI35_13615	COG1705	Flagellar rod assembly protein muramidase FlgJ
VI35_13625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VI35_13630	COG4786	Flagellar basal body rod
VI35_13640	COG1749	Flagellar hook protein flgE
VI35_13650	COG1558	bacterial-type flagellum-dependent cell motility
VI35_13655	COG1815	bacterial-type flagellum-dependent cell motility
VI35_13660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VI35_13665	COG0835	chemotaxis
VI35_13665	COG0784	Response regulator, receiver
VI35_13670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VI35_13685	COG0622	Phosphoesterase
VI35_13690	COG4166	transmembrane transport
VI35_13700	COG1187	pseudouridine synthase activity
VI35_13705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VI35_13715	COG0697	spore germination
VI35_13720	COG4166	transmembrane transport
VI35_13745	COG1278	Cold shock
VI35_13760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VI35_13785	COG3132	Protein of unknown function, DUF480
VI35_13815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VI35_13840	COG2244	polysaccharide biosynthetic process
VI35_13850	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_13855	COG1083	cytidylyl-transferase
VI35_13860	COG0673	inositol 2-dehydrogenase activity
VI35_13875	COG2089	acid synthase
VI35_13880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VI35_13885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VI35_13895	COG1088	dTDP-glucose 4,6-dehydratase activity
VI35_13900	COG0745	RESPONSE REGULATOR receiver
VI35_13915	COG1737	Transcriptional regulator
VI35_13920	COG0469	pyruvate kinase activity
VI35_13930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_13935	COG1960	acyl-CoA dehydrogenase activity
VI35_13960	COG1538	Outer membrane efflux protein
VI35_13970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_13990	COG1946	Acyl-CoA thioesterase
VI35_14005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VI35_14015	COG0009	L-threonylcarbamoyladenylate synthase
VI35_14025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VI35_14030	COG0512	Glutamine amidotransferase of anthranilate synthase
VI35_14030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VI35_14035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VI35_14040	COG0135	phosphoribosylanthranilate isomerase activity
VI35_14040	COG0134	indole-3-glycerol-phosphate synthase activity
VI35_14045	COG0133	tryptophan synthase activity
VI35_14050	COG0159	tryptophan synthase activity
VI35_14060	COG1396	sequence-specific DNA binding
VI35_14065	COG3550	peptidyl-serine autophosphorylation
VI35_14095	COG4521	taurine ABC transporter
VI35_14100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VI35_14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VI35_14115	COG5507	3-demethylubiquinone-9 3-methyltransferase
VI35_14120	COG2814	Major facilitator Superfamily
VI35_14125	COG0109	protoheme IX farnesyltransferase activity
VI35_14130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VI35_14135	COG1845	cytochrome c oxidase, subunit III
VI35_14145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VI35_14150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VI35_14155	COG0583	DNA-binding transcription factor activity
VI35_14175	COG1846	Transcriptional regulator
VI35_14190	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VI35_14225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_14230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_14265	COG2391	methyltransferase activity
VI35_14275	COG0640	Transcriptional regulator
VI35_14295	COG1285	pathogenesis
VI35_14325	COG0484	heat shock protein binding
VI35_14330	COG0443	Heat shock 70 kDa protein
VI35_14335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VI35_14340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VI35_14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_14370	COG1538	Outer membrane efflux protein
VI35_14375	COG2375	cellular response to nickel ion
VI35_14380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_14385	COG2916	Histone family protein nucleoid-structuring protein H-NS
VI35_14390	COG0583	DNA-binding transcription factor activity
VI35_14445	COG0456	acetyltransferase
VI35_14450	COG1187	pseudouridine synthase activity
VI35_14460	COG0482	sulfurtransferase activity
VI35_14465	COG2915	High frequency lysogenization protein hflD homolog
VI35_14470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VI35_14485	COG3264	Mechanosensitive ion channel
VI35_14485	COG1196	nuclear chromosome segregation
VI35_14515	COG0281	malic enzyme
VI35_14520	COG0746	molybdenum cofactor guanylyltransferase activity
VI35_14525	COG1763	Mo-molybdopterin cofactor biosynthetic process
VI35_14530	COG1289	transmembrane transporter activity
VI35_14535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VI35_14575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VI35_14595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VI35_14600	COG0083	homoserine kinase activity
VI35_14610	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VI35_14615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VI35_14640	COG0745	RESPONSE REGULATOR receiver
VI35_14660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VI35_14680	COG1720	tRNA m6t6A37 methyltransferase activity
VI35_14695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VI35_14700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VI35_14705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_14715	COG2190	(PTS) system
VI35_14730	COG0420	3'-5' exonuclease activity
VI35_14750	COG0405	Gamma-glutamyltransferase
VI35_14755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VI35_14755	COG4651	solute:proton antiporter activity
VI35_14795	COG1396	sequence-specific DNA binding
VI35_14795	COG1917	Cupin 2, conserved barrel domain protein
VI35_14800	COG1012	belongs to the aldehyde dehydrogenase family
VI35_14815	COG0531	amino acid
VI35_14820	COG0531	amino acid
VI35_14830	COG1283	sodium-dependent phosphate transmembrane transporter activity
VI35_14840	COG3384	dioxygenase
VI35_14845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_14845	COG2205	protein histidine kinase activity
VI35_14880	COG1388	LysM domain
VI35_14880	COG1376	ErfK ybiS ycfS ynhG family protein
VI35_14895	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VI35_14900	COG0791	NLP P60 protein
VI35_14910	COG3118	belongs to the thioredoxin family
VI35_14920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VI35_14925	COG0788	formyltetrahydrofolate deformylase activity
VI35_14950	COG1196	nuclear chromosome segregation
VI35_14950	COG0739	heme binding
VI35_14950	COG0741	lytic transglycosylase activity
VI35_14955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VI35_14960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VI35_14965	COG0673	inositol 2-dehydrogenase activity
VI35_15005	COG1032	radical SAM domain protein
VI35_15010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_15060	COG0281	malic enzyme
VI35_15065	COG2207	Transcriptional regulator
VI35_15080	COG3706	GGDEF domain
VI35_15080	COG0745	RESPONSE REGULATOR receiver
VI35_15090	COG0095	Lipoate-protein ligase
VI35_15100	COG0019	diaminopimelate decarboxylase activity
VI35_15110	COG0678	peroxiredoxin activity
VI35_15115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VI35_15125	COG1126	abc transporter atp-binding protein
VI35_15135	COG4597	amino acid ABC transporter
VI35_15155	COG1131	(ABC) transporter
VI35_15160	COG0545	Peptidyl-prolyl cis-trans isomerase
VI35_15185	COG1940	carbohydrate kinase activity
VI35_15210	COG0745	RESPONSE REGULATOR receiver
VI35_15215	COG0346	lactoylglutathione lyase activity
VI35_15225	COG3284	Transcriptional regulator
VI35_15230	COG1012	belongs to the aldehyde dehydrogenase family
VI35_15250	COG0667	Aldo Keto reductase
VI35_15275	COG1566	PFAM secretion protein HlyD family protein
VI35_15300	COG0602	queuosine metabolic process
VI35_15305	COG1328	CTP reductase activity
VI35_15315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VI35_15320	COG3115	cell septum assembly
VI35_15345	COG3108	Peptidase M15
VI35_15350	COG2989	Protein conserved in bacteria
VI35_15365	COG0463	Glycosyl transferase, family 2
VI35_15380	COG0366	Alpha amylase catalytic
VI35_15415	COG3706	GGDEF domain
VI35_15420	COG0037	tRNA processing
VI35_15435	COG0488	(ABC) transporter
VI35_15445	COG0531	amino acid
VI35_15450	COG0814	amino acid
VI35_15465	COG0825	malonyl-CoA metabolic process
VI35_15485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_15490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VI35_15495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_15510	COG0750	zinc metalloprotease
VI35_15520	COG0575	Belongs to the CDS family
VI35_15530	COG0233	cytoplasmic translational termination
VI35_15535	COG0528	UMP kinase activity
VI35_15540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VI35_15545	COG0052	Belongs to the universal ribosomal protein uS2 family
VI35_15550	COG0024	Methionine aminopeptidase
VI35_15555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VI35_15560	COG2171	N-acyltransferase activity
VI35_15570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_15570	COG1263	PTS System
VI35_15580	COG4580	involved in the transport of maltose and maltodextrins
VI35_15590	COG0564	pseudouridine synthase activity
VI35_15595	COG3098	single-species biofilm formation
VI35_15620	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VI35_15630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VI35_15630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VI35_15645	COG1611	Belongs to the LOG family
VI35_15655	COG0473	3-isopropylmalate dehydrogenase activity
VI35_15665	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VI35_15670	COG2363	Small membrane protein
VI35_15680	COG0583	DNA-binding transcription factor activity
VI35_15685	COG0840	transmembrane signaling receptor activity
VI35_15690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VI35_15705	COG1477	protein flavinylation
VI35_15710	COG2871	sodium ion transport
VI35_15715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_15720	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_15725	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_15730	COG1805	sodium ion transport
VI35_15735	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_15740	COG0271	Belongs to the BolA IbaG family
VI35_15745	COG2813	Specifically methylates the guanine in position
VI35_15755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VI35_15765	COG2211	Major facilitator Superfamily
VI35_15770	COG3248	Nucleoside-binding outer membrane protein
VI35_15775	COG1666	GTP binding
VI35_15780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VI35_15825	COG3501	Rhs element vgr protein
VI35_15840	COG2771	luxR family
VI35_15845	COG0659	secondary active sulfate transmembrane transporter activity
VI35_15860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VI35_15870	COG1151	hydroxylamine reductase activity
VI35_15875	COG0783	Belongs to the Dps family
VI35_15915	COG4221	oxidoreductase activity
VI35_15925	COG0415	Belongs to the DNA photolyase family
VI35_15930	COG0789	Transcriptional regulator
VI35_15935	COG3272	Protein of unknown function (DUF1722)
VI35_15960	COG0077	Prephenate dehydratase
VI35_15960	COG1605	Chorismate mutase
VI35_15985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_16000	COG0457	Tetratricopeptide repeat
VI35_16015	COG2133	pyrroloquinoline quinone binding
VI35_16025	COG1349	DNA-binding transcription factor activity
VI35_16030	COG2084	Dehydrogenase
VI35_16040	COG0235	Class ii aldolase
VI35_16045	COG3622	Belongs to the hyi family
VI35_16050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VI35_16055	COG2610	gluconate transmembrane transporter activity
VI35_16075	COG0300	oxidoreductase activity
VI35_16120	COG3813	Protein conserved in bacteria
VI35_16135	COG1280	lysine exporter protein (LysE YggA)
VI35_16215	COG1566	PFAM secretion protein HlyD family protein
VI35_16225	COG0114	fumarate hydratase activity
VI35_16235	COG0506	proline dehydrogenase activity
VI35_16235	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VI35_16235	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VI35_16240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VI35_16245	COG0305	Participates in initiation and elongation during chromosome replication
VI35_16260	COG0737	Belongs to the 5'-nucleotidase family
VI35_16285	COG0545	Peptidyl-prolyl cis-trans isomerase
VI35_16295	COG2900	Belongs to the SlyX family
VI35_16300	COG1047	Peptidyl-prolyl cis-trans
VI35_16305	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VI35_16315	COG0835	chemotaxis
VI35_16315	COG0784	Response regulator, receiver
VI35_16325	COG2203	Gaf domain
VI35_16325	COG4251	negative regulation of phosphorylation
VI35_16325	COG3706	GGDEF domain
VI35_16325	COG5001	Diguanylate cyclase
VI35_16330	COG3089	Belongs to the UPF0270 family
VI35_16335	COG3954	Phosphoribulokinase
VI35_16350	COG1765	OsmC-like protein
VI35_16355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VI35_16360	COG2226	methyltransferase
VI35_16375	COG2814	Major facilitator Superfamily
VI35_16400	COG0748	coenzyme F420 binding
VI35_16405	COG3721	Heme iron utilization protein
VI35_16415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_16450	COG0463	Glycosyl transferase, family 2
VI35_16460	COG0741	lytic transglycosylase activity
VI35_16465	COG0488	(ABC) transporter
VI35_16480	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VI35_16490	COG3178	'Phosphotransferase
VI35_16495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VI35_16505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VI35_16510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VI35_16545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VI35_16550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VI35_16555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VI35_16560	COG0142	geranyltranstransferase activity
VI35_16565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VI35_16570	COG0330	HflC and HflK could
VI35_16575	COG0330	HflC and HflK could
VI35_16580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VI35_16585	COG1923	regulation of RNA biosynthetic process
VI35_16590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VI35_16595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VI35_16605	COG0802	atpase or kinase
VI35_16630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VI35_16635	COG2011	ABC-type metal ion transport system permease component
VI35_16640	COG1464	Belongs to the NlpA lipoprotein family
VI35_16675	COG2198	Histidine kinase
VI35_16675	COG5002	protein histidine kinase activity
VI35_16675	COG0784	Response regulator, receiver
VI35_16710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VI35_16715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VI35_16720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VI35_16725	COG2716	regulation of RNA biosynthetic process
VI35_16730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VI35_16735	COG3013	Belongs to the UPF0304 family
VI35_16745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VI35_16750	COG0280	phosphate acetyltransferase
VI35_16750	COG0857	belongs to the CobB CobQ family
VI35_16755	COG0440	acetolactate synthase activity
VI35_16765	COG0028	Belongs to the TPP enzyme family
VI35_16775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VI35_16780	COG0671	phosphoesterase, PA-phosphatase related
VI35_16790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VI35_16795	COG0473	3-isopropylmalate dehydrogenase activity
VI35_16805	COG0066	3-isopropylmalate dehydratase activity
VI35_16830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VI35_16845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_16915	COG1136	(ABC) transporter
VI35_16915	COG0577	efflux transmembrane transporter activity
VI35_16925	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
VI35_16960	COG2203	Gaf domain
VI35_16960	COG2199	diguanylate cyclase activity
VI35_16965	COG0513	Belongs to the DEAD box helicase family
VI35_16975	COG2207	Transcriptional regulator
VI35_16975	COG1917	Cupin 2, conserved barrel domain protein
VI35_17005	COG0154	amidase activity
VI35_17020	COG2852	Protein conserved in bacteria
VI35_17030	COG1902	pentaerythritol trinitrate reductase activity
VI35_17040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VI35_17045	COG0456	acetyltransferase
VI35_17060	COG0745	RESPONSE REGULATOR receiver
VI35_17060	COG3706	GGDEF domain
VI35_17065	COG5002	protein histidine kinase activity
VI35_17065	COG5001	Diguanylate cyclase
VI35_17085	COG0456	acetyltransferase
VI35_17095	COG1022	Amp-dependent synthetase and ligase
VI35_17105	COG1794	racemase activity, acting on amino acids and derivatives
VI35_17120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_17140	COG0733	neurotransmitter:sodium symporter activity
VI35_17155	COG0561	phosphatase activity
VI35_17170	COG1522	sequence-specific DNA binding
VI35_17225	COG1640	4-alpha-glucanotransferase
VI35_17230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VI35_17240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VI35_17245	COG0840	transmembrane signaling receptor activity
VI35_17320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VI35_17325	COG2885	chlorophyll binding
VI35_17330	COG0823	Involved in the tonB-independent uptake of proteins
VI35_17345	COG0811	peptide transport
VI35_17350	COG0824	Thioesterase
VI35_17355	COG3790	cyd operon protein YbgE
VI35_17360	COG4890	Cyd operon protein YbgT
VI35_17365	COG1294	oxidase, subunit
VI35_17370	COG1271	oxidase subunit
VI35_17375	COG2255	four-way junction helicase activity
VI35_17385	COG0632	four-way junction helicase activity
VI35_17395	COG0442	prolyl-tRNA aminoacylation
VI35_17400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_17405	COG4221	oxidoreductase activity
VI35_17420	COG1024	Enoyl-CoA hydratase
VI35_17440	COG4166	transmembrane transport
VI35_17450	COG0840	transmembrane signaling receptor activity
VI35_17455	COG0513	Belongs to the DEAD box helicase family
VI35_17490	COG0457	Tetratricopeptide repeat
VI35_17490	COG3118	belongs to the thioredoxin family
VI35_17500	COG1215	transferase activity, transferring glycosyl groups
VI35_17520	COG2194	sulfuric ester hydrolase activity
VI35_17540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VI35_17545	COG1328	CTP reductase activity
VI35_17575	COG3397	chitin binding
VI35_17585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VI35_17590	COG4208	sulfate ABC transporter
VI35_17605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VI35_17635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VI35_17640	COG0564	pseudouridine synthase activity
VI35_17660	COG0459	protein refolding
VI35_17665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VI35_17675	COG3030	protein affecting phage T7 exclusion by the F plasmid
VI35_17680	COG1027	Aspartate ammonia-lyase
VI35_17690	COG2918	glutathione biosynthetic process
VI35_17700	COG1238	metal cluster binding
VI35_17740	COG0359	binds to the 23S rRNA
VI35_17745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VI35_17750	COG0360	Binds together with S18 to 16S ribosomal RNA
VI35_17755	COG1914	H( )-stimulated, divalent metal cation uptake system
VI35_17765	COG2153	protein acetylation
VI35_17780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VI35_17785	COG0557	exoribonuclease II activity
VI35_17790	COG3706	GGDEF domain
VI35_17795	COG1854	S-ribosylhomocysteine lyase activity
VI35_17845	COG4968	Prepilin-type N-terminal cleavage methylation domain
VI35_17850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VI35_17855	COG1047	Peptidyl-prolyl cis-trans
VI35_17860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VI35_17865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VI35_17870	COG0196	riboflavin kinase activity
VI35_17880	COG0268	Binds directly to 16S ribosomal RNA
VI35_17885	COG0640	Transcriptional regulator
VI35_17890	COG0583	DNA-binding transcription factor activity
VI35_17900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VI35_17905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VI35_17910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VI35_17935	COG0335	large ribosomal subunit rRNA binding
VI35_17940	COG0336	Belongs to the RNA methyltransferase TrmD family
VI35_17945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VI35_17950	COG0228	four-way junction DNA binding
VI35_17955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VI35_17960	COG4137	Cytochrome C assembly protein
VI35_17965	COG4536	flavin adenine dinucleotide binding
VI35_17975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VI35_17975	COG1017	nitric oxide dioxygenase activity
VI35_17980	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VI35_17990	COG0039	L-malate dehydrogenase activity
VI35_17995	COG4160	amino acid transport
VI35_18000	COG4215	(ABC) transporter
VI35_18005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_18010	COG1126	abc transporter atp-binding protein
VI35_18015	COG1438	arginine binding
VI35_18020	COG2837	iron assimilation
VI35_18025	COG3842	ATPase activity
VI35_18040	COG0347	Belongs to the P(II) protein family
VI35_18065	COG0583	DNA-binding transcription factor activity
VI35_18080	COG1929	Belongs to the glycerate kinase type-1 family
VI35_18085	COG2610	gluconate transmembrane transporter activity
VI35_18090	COG3835	regulator
VI35_18095	COG3112	Uncharacterised protein family (UPF0231)
VI35_18115	COG1872	DUF167
VI35_18120	COG0762	integral membrane protein
VI35_18125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VI35_18130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VI35_18140	COG2805	Type II/IV secretion system protein
VI35_18145	COG3022	response to hydroperoxide
VI35_18150	COG0513	Belongs to the DEAD box helicase family
VI35_18155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VI35_18175	COG0735	belongs to the Fur family
VI35_18255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VI35_18270	COG0776	regulation of translation
VI35_18275	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VI35_18285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VI35_18300	COG0560	Phosphoserine phosphatase
VI35_18310	COG5001	Diguanylate cyclase
VI35_18310	COG3447	MASE1 domain protein
VI35_18310	COG5002	protein histidine kinase activity
VI35_18315	COG0813	purine-nucleoside phosphorylase activity
VI35_18320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VI35_18325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VI35_18330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VI35_18340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VI35_18350	COG4968	Prepilin-type N-terminal cleavage methylation domain
VI35_18360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_18365	COG0004	ammonium transporteR
VI35_18385	COG0795	lipopolysaccharide-transporting ATPase activity
VI35_18390	COG0795	lipopolysaccharide-transporting ATPase activity
VI35_18395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VI35_18400	COG2927	DNA polymerase III (CHI subunit)
VI35_18405	COG0525	valine-tRNA ligase activity
VI35_18410	COG1253	flavin adenine dinucleotide binding
VI35_18415	COG0586	Pfam SNARE associated Golgi protein
VI35_18420	COG1686	Belongs to the peptidase S11 family
VI35_18455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VI35_18460	COG0527	aspartate kinase activity
VI35_18465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VI35_18475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VI35_18480	COG1546	Belongs to the CinA family
VI35_18490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VI35_18510	COG3068	Protein conserved in bacteria
VI35_18520	COG0739	heme binding
VI35_18540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VI35_18545	COG1121	(ABC) transporter
VI35_18550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VI35_18565	COG1573	uracil-dna glycosylase
VI35_18570	COG2962	Rard protein
VI35_18575	COG2827	Endonuclease containing a URI domain
VI35_18590	COG1842	Phage shock protein A
VI35_18595	COG0204	Acyl-transferase
VI35_18620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VI35_18670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VI35_18685	COG0187	DNA topoisomerase II activity
VI35_18690	COG1289	transmembrane transporter activity
VI35_18695	COG1566	PFAM secretion protein HlyD family protein
VI35_18710	COG1051	belongs to the nudix hydrolase family
VI35_18715	COG3150	esterase
VI35_18725	COG3151	Protein conserved in bacteria
VI35_18730	COG0494	nUDIX hydrolase
VI35_18735	COG1538	Outer membrane efflux protein
VI35_18740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VI35_18740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VI35_18745	COG1560	Kdo2-lipid A biosynthetic process
VI35_18760	COG2771	luxR family
VI35_18765	COG3916	Acyl-homoserine-lactone synthase
VI35_18775	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VI35_18780	COG2213	PTS system mannitol-specific
VI35_18780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_18785	COG0246	Mannitol dehydrogenase
VI35_18790	COG3722	fumarate hydratase activity
VI35_18830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VI35_18835	COG0513	Belongs to the DEAD box helicase family
VI35_18855	COG1575	Belongs to the MenA family. Type 1 subfamily
VI35_18870	COG0596	Alpha beta hydrolase
VI35_18875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VI35_18890	COG3291	Pkd domain containing protein
VI35_18895	COG2949	membrane
VI35_18910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VI35_18950	COG1979	alcohol dehydrogenase
VI35_18965	COG4221	oxidoreductase activity
VI35_18985	COG1285	pathogenesis
VI35_19000	COG1368	sulfuric ester hydrolase activity
VI35_19005	COG1522	sequence-specific DNA binding
VI35_19015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VI35_19025	COG1058	Belongs to the CinA family
VI35_19025	COG1546	Belongs to the CinA family
VI35_19030	COG1988	membrane-bound metal-dependent
VI35_19045	COG0561	phosphatase activity
VI35_19050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VI35_19075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VI35_19080	COG0019	diaminopimelate decarboxylase activity
VI35_19090	COG1965	Belongs to the frataxin family
VI35_19095	COG0400	carboxylic ester hydrolase activity
VI35_19100	COG3072	Adenylate cyclase
VI35_19105	COG0181	hydroxymethylbilane synthase activity
VI35_19115	COG2959	enzyme of heme biosynthesis
VI35_19120	COG3071	HemY protein
VI35_19130	COG1494	fructose-1,6-bisphosphatase
VI35_19160	COG1733	regulation of RNA biosynthetic process
VI35_19180	COG3932	Exopolysaccharide synthesis, ExoD
VI35_19185	COG2199	diguanylate cyclase activity
VI35_19185	COG2203	Gaf domain
VI35_19195	COG0110	maltose O-acetyltransferase activity
VI35_19235	COG2022	thiamine diphosphate biosynthetic process
VI35_19250	COG0352	thiamine-phosphate diphosphorylase activity
VI35_19255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VI35_19270	COG0745	RESPONSE REGULATOR receiver
VI35_19280	COG0189	ligase activity
VI35_19315	COG2321	neutral zinc metallopeptidase
VI35_19330	COG1366	Belongs to the anti-sigma-factor antagonist family
VI35_19335	COG2172	sigma factor antagonist activity
VI35_19345	COG3437	response regulator, receiver
VI35_19375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VI35_19390	COG0424	maF-like protein
VI35_19395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VI35_19400	COG1792	Involved in formation and maintenance of cell shape
VI35_19405	COG1077	Cell shape determining protein MreB Mrl
VI35_19455	COG1459	type II secretion system
VI35_19510	COG2200	EAL domain
VI35_19515	COG0387	Pfam Sodium calcium exchanger
VI35_19520	COG2986	histidine ammonia-lyase
VI35_19525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VI35_19530	COG0010	Belongs to the arginase family
VI35_19535	COG1228	amidohydrolase
VI35_19540	COG2188	Transcriptional regulator
VI35_19545	COG0288	reversible hydration of carbon dioxide
VI35_19555	COG2177	Part of the ABC transporter FtsEX involved in
VI35_19560	COG2884	Cell division ATP-binding protein ftsE
VI35_19565	COG0552	protein localization to endoplasmic reticulum
VI35_19595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VI35_19600	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VI35_19610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_19620	COG2095	MarC family integral membrane protein
VI35_19630	COG1301	dicarboxylic acid transport
VI35_19640	COG0583	DNA-binding transcription factor activity
VI35_19655	COG3714	YhhN family
VI35_19675	COG1770	oligopeptidase
VI35_19690	COG4221	oxidoreductase activity
VI35_19695	COG0583	DNA-binding transcription factor activity
VI35_19760	COG0203	ribosomal protein L17
VI35_19765	COG0202	RNA polymerase activity
VI35_19770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VI35_19775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VI35_19780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VI35_19785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VI35_19790	COG0201	protein transport
VI35_19795	COG0200	Binds to the 23S rRNA
VI35_19800	COG1841	ribosomal large subunit assembly
VI35_19805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VI35_19810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VI35_19815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VI35_19820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VI35_19825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VI35_19830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VI35_19835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VI35_19840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VI35_19845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VI35_19850	COG0255	Belongs to the universal ribosomal protein uL29 family
VI35_19855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VI35_19860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VI35_19865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VI35_19870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VI35_19875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VI35_19880	COG0089	rRNA binding
VI35_19885	COG0088	Forms part of the polypeptide exit tunnel
VI35_19890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VI35_19895	COG0051	transcription antitermination factor activity, RNA binding
VI35_19905	COG2205	protein histidine kinase activity
VI35_19910	COG0745	RESPONSE REGULATOR receiver
VI35_19915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VI35_19920	COG2183	response to ionizing radiation
VI35_19935	COG0596	Alpha beta hydrolase
VI35_19940	COG1040	competence protein
VI35_19945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VI35_19945	COG0316	Belongs to the HesB IscA family
VI35_19950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VI35_19955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VI35_19960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_19965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VI35_19970	COG4942	peptidase
VI35_19995	COG0800	Aldolase
VI35_20000	COG0129	dihydroxy-acid dehydratase activity
VI35_20005	COG3265	gluconokinase activity
VI35_20010	COG2610	gluconate transmembrane transporter activity
VI35_20030	COG0456	acetyltransferase
VI35_20040	COG1490	D-aminoacyl-tRNA deacylase activity
VI35_20045	COG1295	ribonuclease BN
VI35_20055	COG0174	glutamine synthetase
VI35_20065	COG3852	Histidine kinase
VI35_20075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VI35_20080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VI35_20090	COG3078	GTPase activator activity
VI35_20100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VI35_20105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VI35_20115	COG0009	L-threonylcarbamoyladenylate synthase
VI35_20120	COG0551	DNA topoisomerase type I activity
VI35_20125	COG2922	Belongs to the Smg family
VI35_20140	COG0242	peptide deformylase activity
VI35_20145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VI35_20150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_20150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_20155	COG0569	domain protein
VI35_20165	COG1322	Protein conserved in bacteria
VI35_20195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VI35_20195	COG0519	Catalyzes the synthesis of GMP from XMP
VI35_20210	COG1396	sequence-specific DNA binding
VI35_20215	COG1012	belongs to the aldehyde dehydrogenase family
VI35_20220	COG2962	Rard protein
VI35_20270	COG0583	DNA-binding transcription factor activity
VI35_20300	COG0210	DNA helicase
VI35_20325	COG0583	DNA-binding transcription factor activity
VI35_20350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VI35_20355	COG0385	Bile acid
VI35_20360	COG0531	amino acid
VI35_20365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_20370	COG0531	amino acid
VI35_20375	COG2731	YhcH YjgK YiaL family protein
VI35_20380	COG3250	beta-galactosidase activity
VI35_20385	COG1609	Transcriptional regulator
VI35_20425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VI35_20430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VI35_20430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VI35_20435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VI35_20440	COG3074	FtsZ-dependent cytokinesis
VI35_20460	COG0745	RESPONSE REGULATOR receiver
VI35_20465	COG2205	protein histidine kinase activity
VI35_20470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VI35_20475	COG0534	Mate efflux family protein
VI35_20490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VI35_20495	COG2937	Belongs to the GPAT DAPAT family
VI35_20500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VI35_20505	COG3161	chorismate lyase activity
VI35_20510	COG1580	Controls the rotational direction of flagella during chemotaxis
VI35_20580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VI35_20590	COG0156	8-amino-7-oxononanoate synthase activity
VI35_20595	COG1063	alcohol dehydrogenase
VI35_20620	COG2166	iron-sulfur cluster assembly
VI35_20625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VI35_20655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VI35_20670	COG0006	proline dipeptidase activity
VI35_20675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VI35_20685	COG0183	Belongs to the thiolase family
VI35_20690	COG0745	RESPONSE REGULATOR receiver
VI35_20695	COG2205	protein histidine kinase activity
VI35_20725	COG0425	Belongs to the sulfur carrier protein TusA family
VI35_20730	COG0251	oxidation-reduction process
VI35_20745	COG2885	chlorophyll binding
VI35_20755	COG1335	isochorismatase
VI35_20760	COG2818	Glycosylase
VI35_20765	COG0752	glycyl-tRNA synthetase alpha subunit
VI35_20770	COG0751	glycine-tRNA ligase activity
VI35_20780	COG2203	Gaf domain
VI35_20780	COG3706	GGDEF domain
VI35_20780	COG4251	negative regulation of phosphorylation
VI35_20780	COG5001	Diguanylate cyclase
VI35_20805	COG0814	amino acid
VI35_20820	COG0348	domain, Protein
VI35_20830	COG0446	pyridine nucleotide-disulphide oxidoreductase
VI35_20835	COG1773	rubredoxin
VI35_20835	COG0426	domain, Protein
VI35_20840	COG3604	Transcriptional regulator
VI35_20845	COG1609	Transcriptional regulator
VI35_20855	COG0559	Belongs to the binding-protein-dependent transport system permease family
VI35_20885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_20915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VI35_20925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VI35_20930	COG3118	belongs to the thioredoxin family
VI35_20940	COG0248	Ppx GppA phosphatase
VI35_20950	COG0742	ribosomal rna small subunit methyltransferase
VI35_20970	COG0084	hydrolase, TatD family'
VI35_20975	COG0805	protein transport
VI35_20980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_20985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_20990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VI35_20995	COG3165	ubiquinone biosynthetic process from chorismate
VI35_21010	COG0402	S-adenosylhomocysteine deaminase activity
VI35_21045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VI35_21050	COG0848	biopolymer transport protein
VI35_21055	COG0811	peptide transport
VI35_21060	COG0811	peptide transport
VI35_21070	COG2771	luxR family
VI35_21075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VI35_21080	COG1349	DNA-binding transcription factor activity
VI35_21085	COG0745	RESPONSE REGULATOR receiver
VI35_21100	COG4452	Inner membrane protein CreD
VI35_21105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VI35_21110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VI35_21115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VI35_21120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VI35_21125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VI35_21130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VI35_21135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VI35_21145	COG0356	it plays a direct role in the translocation of protons across the membrane
VI35_21155	COG1475	DNA binding
VI35_21160	COG1192	Involved in chromosome partitioning
VI35_21165	COG0357	Ribosomal RNA small subunit methyltransferase G
VI35_21170	COG0445	tRNA wobble uridine modification
VI35_21180	COG4774	siderophore transport
VI35_21185	COG4615	Cyclic peptide transporter
VI35_21190	COG1120	ATPase activity
VI35_21195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VI35_21205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VI35_21210	COG0706	membrane insertase activity
VI35_21215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VI35_21220	COG0594	ribonuclease P activity
VI35_21225	COG0230	Belongs to the bacterial ribosomal protein bL34 family