locus-tag	class	description
JH254_00020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JH254_00025	COG0564	pseudouridine synthase activity
JH254_00045	COG0459	protein refolding
JH254_00050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JH254_00055	COG0534	Mate efflux family protein
JH254_00060	COG3030	protein affecting phage T7 exclusion by the F plasmid
JH254_00065	COG1027	Aspartate ammonia-lyase
JH254_00070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JH254_00075	COG2918	glutathione biosynthetic process
JH254_00080	COG0612	Peptidase, M16
JH254_00085	COG1238	metal cluster binding
JH254_00090	COG1064	alcohol dehydrogenase
JH254_00120	COG0359	binds to the 23S rRNA
JH254_00125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JH254_00130	COG0360	Binds together with S18 to 16S ribosomal RNA
JH254_00135	COG1914	H( )-stimulated, divalent metal cation uptake system
JH254_00145	COG2153	protein acetylation
JH254_00160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JH254_00165	COG0557	exoribonuclease II activity
JH254_00170	COG3706	GGDEF domain
JH254_00175	COG1854	S-ribosylhomocysteine lyase activity
JH254_00190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JH254_00190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JH254_00220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JH254_00225	COG1047	Peptidyl-prolyl cis-trans
JH254_00230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JH254_00235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JH254_00240	COG0196	riboflavin kinase activity
JH254_00245	COG0728	peptidoglycan biosynthetic process
JH254_00250	COG0268	Binds directly to 16S ribosomal RNA
JH254_00255	COG0640	Transcriptional regulator
JH254_00260	COG0583	DNA-binding transcription factor activity
JH254_00270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JH254_00275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JH254_00280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JH254_00290	COG1051	belongs to the nudix hydrolase family
JH254_00295	COG3066	DNA modification
JH254_00305	COG0335	large ribosomal subunit rRNA binding
JH254_00310	COG0336	Belongs to the RNA methyltransferase TrmD family
JH254_00315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JH254_00320	COG0228	four-way junction DNA binding
JH254_00325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JH254_00330	COG4137	Cytochrome C assembly protein
JH254_00335	COG4536	flavin adenine dinucleotide binding
JH254_00345	COG1017	nitric oxide dioxygenase activity
JH254_00345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JH254_00350	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JH254_00355	COG0039	L-malate dehydrogenase activity
JH254_00360	COG4160	amino acid transport
JH254_00365	COG4215	(ABC) transporter
JH254_00370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_00375	COG1126	abc transporter atp-binding protein
JH254_00380	COG1438	arginine binding
JH254_00385	COG2837	iron assimilation
JH254_00390	COG3842	ATPase activity
JH254_00400	COG1840	ABC-type Fe3 transport system, periplasmic component
JH254_00405	COG0347	Belongs to the P(II) protein family
JH254_00420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JH254_00425	COG0583	DNA-binding transcription factor activity
JH254_00440	COG1929	Belongs to the glycerate kinase type-1 family
JH254_00445	COG2610	gluconate transmembrane transporter activity
JH254_00450	COG3835	regulator
JH254_00455	COG3112	Uncharacterised protein family (UPF0231)
JH254_00475	COG1872	DUF167
JH254_00480	COG0762	integral membrane protein
JH254_00485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JH254_00490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JH254_00505	COG3022	response to hydroperoxide
JH254_00510	COG0513	Belongs to the DEAD box helicase family
JH254_00515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JH254_00535	COG0735	belongs to the Fur family
JH254_00540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JH254_00555	COG0776	regulation of translation
JH254_00560	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JH254_00570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JH254_00585	COG0560	Phosphoserine phosphatase
JH254_00595	COG3447	MASE1 domain protein
JH254_00595	COG5001	Diguanylate cyclase
JH254_00595	COG5002	protein histidine kinase activity
JH254_00600	COG0813	purine-nucleoside phosphorylase activity
JH254_00605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JH254_00610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JH254_00615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JH254_00625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JH254_00630	COG0084	hydrolase, TatD family'
JH254_00635	COG2165	general secretion pathway protein
JH254_00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JH254_00655	COG0004	ammonium transporteR
JH254_00720	COG0795	lipopolysaccharide-transporting ATPase activity
JH254_00725	COG0795	lipopolysaccharide-transporting ATPase activity
JH254_00730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JH254_00740	COG0525	valine-tRNA ligase activity
JH254_00745	COG1253	flavin adenine dinucleotide binding
JH254_00750	COG0586	Pfam SNARE associated Golgi protein
JH254_00755	COG1686	Belongs to the peptidase S11 family
JH254_00790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JH254_00795	COG0527	aspartate kinase activity
JH254_00800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JH254_00810	COG2137	regulation of response to DNA damage stimulus
JH254_00815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JH254_00820	COG1546	Belongs to the CinA family
JH254_00830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JH254_00875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JH254_00880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JH254_00895	COG0477	Major facilitator Superfamily
JH254_00900	COG0523	cobalamin synthesis protein
JH254_00910	COG1280	lysine exporter protein (LysE YggA)
JH254_00920	COG2200	EAL domain
JH254_00925	COG1049	propionate catabolic process, 2-methylcitrate cycle
JH254_00930	COG1752	Esterase of the alpha-beta hydrolase superfamily
JH254_00935	COG0840	transmembrane signaling receptor activity
JH254_00945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH254_00950	COG0508	dehydrogenase complex catalyzes the overall conversion of
JH254_00955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JH254_00960	COG2186	Transcriptional regulator
JH254_00985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JH254_00990	COG1459	type II secretion system
JH254_00995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JH254_01005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JH254_01010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JH254_01015	COG0494	nUDIX hydrolase
JH254_01025	COG0653	protein targeting
JH254_01035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JH254_01040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JH254_01045	COG0849	cell division
JH254_01050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JH254_01055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JH254_01060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JH254_01065	COG0772	Belongs to the SEDS family
JH254_01070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JH254_01075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JH254_01080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JH254_01085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JH254_01090	COG0768	penicillin binding
JH254_01095	COG3116	cell division
JH254_01100	COG0275	rRNA processing
JH254_01105	COG2001	Belongs to the MraZ family
JH254_01115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JH254_01120	COG3107	peptidoglycan biosynthetic process
JH254_01125	COG0792	nuclease activity
JH254_01130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JH254_01135	COG2823	Periplasmic or secreted lipoprotein
JH254_01140	COG2969	positive regulation of protein catabolic process
JH254_01145	COG0625	glutathione transferase activity
JH254_01150	COG2857	Cytochrome c1
JH254_01155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JH254_01160	COG0723	plastoquinol--plastocyanin reductase activity
JH254_01165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JH254_01170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JH254_01175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JH254_01185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JH254_01190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JH254_01220	COG3964	amidohydrolase
JH254_01240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_01245	COG1660	Displays ATPase and GTPase activities
JH254_01250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_01260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JH254_01265	COG1137	ATPase activity
JH254_01270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JH254_01280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JH254_01285	COG0517	IMP dehydrogenase activity
JH254_01285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JH254_01290	COG1127	ABC transporter
JH254_01295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JH254_01300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JH254_01305	COG2854	intermembrane phospholipid transfer
JH254_01315	COG5007	Belongs to the BolA IbaG family
JH254_01320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JH254_01330	COG1494	fructose-1,6-bisphosphatase
JH254_01340	COG2226	methyltransferase
JH254_01345	COG0454	-acetyltransferase
JH254_01345	COG0456	acetyltransferase
JH254_01360	COG1733	regulation of RNA biosynthetic process
JH254_01380	COG3932	Exopolysaccharide synthesis, ExoD
JH254_01395	COG0110	maltose O-acetyltransferase activity
JH254_01410	COG1368	sulfuric ester hydrolase activity
JH254_01425	COG1285	pathogenesis
JH254_01445	COG4221	oxidoreductase activity
JH254_01460	COG1979	alcohol dehydrogenase
JH254_01470	COG2873	o-acetylhomoserine
JH254_01500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JH254_01510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JH254_01515	COG2949	membrane
JH254_01520	COG3291	Pkd domain containing protein
JH254_01525	COG0318	PFAM AMP-dependent synthetase and ligase
JH254_01535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JH254_01540	COG0596	Alpha beta hydrolase
JH254_01545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JH254_01550	COG1169	isochorismate synthase
JH254_01555	COG1575	Belongs to the MenA family. Type 1 subfamily
JH254_01575	COG0513	Belongs to the DEAD box helicase family
JH254_01580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JH254_01595	COG1671	Belongs to the UPF0178 family
JH254_01615	COG3263	regulation of cellular component size
JH254_01620	COG3722	fumarate hydratase activity
JH254_01625	COG0246	Mannitol dehydrogenase
JH254_01630	COG2213	PTS system mannitol-specific
JH254_01630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_01635	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JH254_01645	COG3916	Acyl-homoserine-lactone synthase
JH254_01650	COG2771	luxR family
JH254_01665	COG1560	Kdo2-lipid A biosynthetic process
JH254_01670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JH254_01670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JH254_01675	COG1538	Outer membrane efflux protein
JH254_01680	COG0494	nUDIX hydrolase
JH254_01685	COG3151	Protein conserved in bacteria
JH254_01695	COG3150	esterase
JH254_01700	COG1051	belongs to the nudix hydrolase family
JH254_01715	COG1566	PFAM secretion protein HlyD family protein
JH254_01720	COG1289	transmembrane transporter activity
JH254_01780	COG0484	heat shock protein binding
JH254_01790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH254_01810	COG0204	Acyl-transferase
JH254_01815	COG1842	Phage shock protein A
JH254_01830	COG2827	Endonuclease containing a URI domain
JH254_01835	COG2962	Rard protein
JH254_01840	COG1573	uracil-dna glycosylase
JH254_01850	COG0583	DNA-binding transcription factor activity
JH254_01855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JH254_01860	COG1121	(ABC) transporter
JH254_01865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JH254_01885	COG0739	heme binding
JH254_01895	COG3068	Protein conserved in bacteria
JH254_01925	COG1522	sequence-specific DNA binding
JH254_01930	COG0110	maltose O-acetyltransferase activity
JH254_01935	COG0366	Alpha amylase catalytic
JH254_01940	COG1263	PTS System
JH254_01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JH254_01960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JH254_01965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JH254_01970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JH254_01975	COG2723	6-phospho-beta-galactosidase activity
JH254_01980	COG1447	Phosphotransferase system cellobiose-specific component IIA
JH254_01985	COG1940	carbohydrate kinase activity
JH254_02010	COG1609	Transcriptional regulator
JH254_02020	COG0252	asparaginase activity
JH254_02035	COG1803	Methylglyoxal synthase
JH254_02055	COG1444	tRNA N-acetyltransferase activity
JH254_02060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JH254_02060	COG1565	acr, cog1565
JH254_02070	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JH254_02100	COG0109	protoheme IX farnesyltransferase activity
JH254_02110	COG0583	DNA-binding transcription factor activity
JH254_02115	COG1757	Na H antiporter
JH254_02155	COG0297	glycogen (starch) synthase activity
JH254_02160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JH254_02165	COG2813	Specifically methylates the guanine in position
JH254_02170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JH254_02175	COG2203	Gaf domain
JH254_02175	COG4251	negative regulation of phosphorylation
JH254_02175	COG5001	Diguanylate cyclase
JH254_02175	COG3706	GGDEF domain
JH254_02180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH254_02190	COG2995	paraquat-inducible protein a
JH254_02195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JH254_02195	COG3008	intermembrane lipid transfer
JH254_02200	COG3009	Protein conserved in bacteria
JH254_02210	COG3240	lipase activity
JH254_02225	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JH254_02230	COG1194	a g-specific adenine glycosylase
JH254_02240	COG3267	Type II secretory pathway component ExeA
JH254_02240	COG3409	Peptidoglycan-binding domain 1 protein
JH254_02245	COG0617	tRNA 3'-terminal CCA addition
JH254_02250	COG0306	phosphate transporter
JH254_02255	COG1392	Phosphate transport regulator
JH254_02260	COG3025	triphosphatase activity
JH254_02265	COG3133	Outer membrane lipoprotein
JH254_02285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JH254_02290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JH254_02300	COG3031	protein transport across the cell outer membrane
JH254_02310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JH254_02315	COG1459	type II secretion system
JH254_02320	COG2165	general secretion pathway protein
JH254_02330	COG2165	general secretion pathway protein
JH254_02335	COG4795	General secretion pathway protein
JH254_02345	COG3156	type II secretion system protein K
JH254_02355	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JH254_02370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JH254_02385	COG1011	Hydrolase
JH254_02390	COG0494	nUDIX hydrolase
JH254_02395	COG1218	3'(2'),5'-bisphosphate nucleotidase
JH254_02400	COG0814	amino acid
JH254_02405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JH254_02420	COG0626	cystathionine gamma-synthase activity
JH254_02425	COG0527	aspartate kinase activity
JH254_02425	COG0460	homoserine dehydrogenase
JH254_02430	COG1346	cytolysis
JH254_02435	COG1380	Effector of murein hydrolase LrgA
JH254_02440	COG0583	DNA-binding transcription factor activity
JH254_02475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JH254_02480	COG3447	MASE1 domain protein
JH254_02480	COG5002	protein histidine kinase activity
JH254_02480	COG5001	Diguanylate cyclase
JH254_02485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JH254_02495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JH254_02500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JH254_02510	COG0137	argininosuccinate synthase activity
JH254_02515	COG0165	Argininosuccinate lyase
JH254_02520	COG0583	DNA-binding transcription factor activity
JH254_02530	COG1942	4-Oxalocrotonate Tautomerase
JH254_02560	COG0110	maltose O-acetyltransferase activity
JH254_02565	COG3174	membrane
JH254_02570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_02575	COG1126	abc transporter atp-binding protein
JH254_02580	COG0765	amino acid transport
JH254_02585	COG0765	amino acid transport
JH254_02595	COG1505	serine-type exopeptidase activity
JH254_02605	COG1028	Short-chain dehydrogenase reductase Sdr
JH254_02610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JH254_02625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JH254_02630	COG4991	sh3 domain protein
JH254_02640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JH254_02645	COG1940	carbohydrate kinase activity
JH254_02650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JH254_02655	COG0126	phosphoglycerate kinase activity
JH254_02665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH254_02670	COG5433	transposase activity
JH254_02675	COG1032	radical SAM domain protein
JH254_02680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH254_02690	COG3706	GGDEF domain
JH254_02695	COG1752	Esterase of the alpha-beta hydrolase superfamily
JH254_02700	COG0733	neurotransmitter:sodium symporter activity
JH254_02730	COG0281	malic enzyme
JH254_02735	COG2207	Transcriptional regulator
JH254_02740	COG0534	Mate efflux family protein
JH254_02755	COG2233	PERMEase
JH254_02760	COG0095	Lipoate-protein ligase
JH254_02765	COG1115	amino acid carrier protein
JH254_02770	COG0019	diaminopimelate decarboxylase activity
JH254_02780	COG0678	peroxiredoxin activity
JH254_02785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JH254_02795	COG1126	abc transporter atp-binding protein
JH254_02800	COG0765	amino acid transport
JH254_02805	COG4597	amino acid ABC transporter
JH254_02810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_02825	COG1131	(ABC) transporter
JH254_02830	COG0545	Peptidyl-prolyl cis-trans isomerase
JH254_02865	COG5433	transposase activity
JH254_02880	COG5002	protein histidine kinase activity
JH254_02885	COG0745	RESPONSE REGULATOR receiver
JH254_02890	COG0346	lactoylglutathione lyase activity
JH254_02895	COG3706	GGDEF domain
JH254_02900	COG3284	Transcriptional regulator
JH254_02915	COG0697	spore germination
JH254_02925	COG0667	Aldo Keto reductase
JH254_02940	COG3290	protein histidine kinase activity
JH254_02950	COG1566	PFAM secretion protein HlyD family protein
JH254_02975	COG0602	queuosine metabolic process
JH254_02980	COG1328	CTP reductase activity
JH254_02990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JH254_02995	COG3115	cell septum assembly
JH254_03000	COG1196	nuclear chromosome segregation
JH254_03010	COG2860	membrane
JH254_03020	COG3108	Peptidase M15
JH254_03025	COG2989	Protein conserved in bacteria
JH254_03040	COG0463	Glycosyl transferase, family 2
JH254_03055	COG0366	Alpha amylase catalytic
JH254_03090	COG3706	GGDEF domain
JH254_03095	COG0037	tRNA processing
JH254_03100	COG3590	peptidase
JH254_03110	COG0488	(ABC) transporter
JH254_03120	COG0531	amino acid
JH254_03125	COG0814	amino acid
JH254_03140	COG0825	malonyl-CoA metabolic process
JH254_03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JH254_03155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JH254_03160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JH254_03165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JH254_03170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JH254_03185	COG0750	zinc metalloprotease
JH254_03190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JH254_03195	COG0575	Belongs to the CDS family
JH254_03200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JH254_03205	COG0233	cytoplasmic translational termination
JH254_03210	COG0528	UMP kinase activity
JH254_03215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JH254_03220	COG0052	Belongs to the universal ribosomal protein uS2 family
JH254_03225	COG0024	Methionine aminopeptidase
JH254_03230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JH254_03235	COG2171	N-acyltransferase activity
JH254_03255	COG4580	involved in the transport of maltose and maltodextrins
JH254_03265	COG0564	pseudouridine synthase activity
JH254_03270	COG3098	single-species biofilm formation
JH254_03295	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JH254_03305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JH254_03305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JH254_03320	COG1611	Belongs to the LOG family
JH254_03325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JH254_03330	COG0473	3-isopropylmalate dehydrogenase activity
JH254_03340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JH254_03345	COG2363	Small membrane protein
JH254_03355	COG0583	DNA-binding transcription factor activity
JH254_03360	COG0840	transmembrane signaling receptor activity
JH254_03365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JH254_03380	COG1477	protein flavinylation
JH254_03385	COG2871	sodium ion transport
JH254_03390	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JH254_03395	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JH254_03400	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JH254_03405	COG1805	sodium ion transport
JH254_03410	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JH254_03415	COG0271	Belongs to the BolA IbaG family
JH254_03420	COG2813	Specifically methylates the guanine in position
JH254_03430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JH254_03440	COG2211	Major facilitator Superfamily
JH254_03450	COG1666	GTP binding
JH254_03455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JH254_03515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JH254_03520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JH254_03525	COG2223	nitrite transmembrane transporter activity
JH254_03530	COG3279	Response regulator of the LytR AlgR family
JH254_03535	COG3275	phosphorelay sensor kinase activity
JH254_03565	COG5433	transposase activity
JH254_03575	COG2197	response regulator
JH254_03580	COG3850	Histidine kinase
JH254_03585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JH254_03590	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
JH254_03590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JH254_03600	COG0243	molybdopterin cofactor binding
JH254_03605	COG0437	4 iron, 4 sulfur cluster binding
JH254_03610	COG0348	domain, Protein
JH254_03620	COG3005	denitrification pathway
JH254_03625	COG0521	Mo-molybdopterin cofactor biosynthetic process
JH254_03630	COG0315	cyclic pyranopterin monophosphate synthase activity
JH254_03635	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JH254_03640	COG0314	molybdopterin synthase activity
JH254_03655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JH254_03660	COG2267	carboxylic ester hydrolase activity
JH254_03665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JH254_03675	COG0302	gtp cyclohydrolase
JH254_03680	COG0840	transmembrane signaling receptor activity
JH254_03685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JH254_03695	COG0583	DNA-binding transcription factor activity
JH254_03710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JH254_03725	COG2195	Cleaves the N-terminal amino acid of tripeptides
JH254_03730	COG1166	arginine decarboxylase activity
JH254_03755	COG1061	Type III restriction enzyme res subunit
JH254_03775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JH254_03780	COG1187	pseudouridine synthase activity
JH254_03785	COG2807	transmembrane transport
JH254_03795	COG0583	DNA-binding transcription factor activity
JH254_03815	COG2979	Protein of unknown function (DUF533)
JH254_03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JH254_03830	COG1271	oxidase subunit
JH254_03835	COG1294	oxidase, subunit
JH254_03845	COG2814	Major facilitator Superfamily
JH254_03850	COG0656	L-ascorbic acid biosynthetic process
JH254_03870	COG0583	DNA-binding transcription factor activity
JH254_03875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JH254_03880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JH254_03885	COG2271	Major facilitator Superfamily
JH254_03890	COG1349	DNA-binding transcription factor activity
JH254_03900	COG0584	glycerophosphoryl diester phosphodiesterase
JH254_03905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JH254_03910	COG1605	Chorismate mutase
JH254_03910	COG0287	Prephenate dehydrogenase
JH254_03920	COG3085	chromosome segregation
JH254_03925	COG4574	serine-type endopeptidase inhibitor activity
JH254_03945	COG1770	oligopeptidase
JH254_03950	COG4771	TonB-dependent receptor
JH254_03955	COG3083	sulfuric ester hydrolase activity
JH254_03960	COG3082	Protein of unknown function (DUF1414)
JH254_03965	COG3081	Nucleoid-associated protein
JH254_03975	COG1175	transmembrane transport
JH254_03980	COG3833	ABC-type maltose transport systems, permease component
JH254_03985	COG3842	ATPase activity
JH254_03995	COG0596	Alpha beta hydrolase
JH254_04010	COG0425	Belongs to the sulfur carrier protein TusA family
JH254_04015	COG4783	chaperone-mediated protein folding
JH254_04025	COG1393	Belongs to the ArsC family
JH254_04050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_04055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JH254_04060	COG2431	L-lysine efflux transmembrane transporter activity
JH254_04070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_04080	COG4160	amino acid transport
JH254_04090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JH254_04100	COG0446	pyridine nucleotide-disulphide oxidoreductase
JH254_04125	COG0628	permease
JH254_04130	COG2373	Large extracellular alpha-helical protein
JH254_04135	COG4953	penicillin-binding protein 1C
JH254_04145	COG0301	tRNA thio-modification
JH254_04145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JH254_04150	COG3385	transposase activity
JH254_04170	COG0300	oxidoreductase activity
JH254_04195	COG3214	Protein conserved in bacteria
JH254_04210	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JH254_04215	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JH254_04220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JH254_04225	COG1053	succinate dehydrogenase
JH254_04235	COG0584	glycerophosphoryl diester phosphodiesterase
JH254_04240	COG1511	domain protein
JH254_04240	COG3264	Mechanosensitive ion channel
JH254_04250	COG0739	heme binding
JH254_04265	COG0583	DNA-binding transcription factor activity
JH254_04280	COG0583	DNA-binding transcription factor activity
JH254_04285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JH254_04315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JH254_04320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JH254_04330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JH254_04335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JH254_04340	COG0546	phosphoglycolate phosphatase activity
JH254_04345	COG0180	Tryptophanyl-tRNA synthetase
JH254_04360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JH254_04370	COG1012	belongs to the aldehyde dehydrogenase family
JH254_04385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH254_04400	COG0657	acetylesterase activity
JH254_04410	COG0490	domain, Protein
JH254_04410	COG0471	metal ion transport
JH254_04440	COG3813	Protein conserved in bacteria
JH254_04450	COG0826	peptidase U32
JH254_04455	COG1280	lysine exporter protein (LysE YggA)
JH254_04465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JH254_04490	COG2199	diguanylate cyclase activity
JH254_04490	COG2203	Gaf domain
JH254_04490	COG2200	EAL domain
JH254_04535	COG1566	PFAM secretion protein HlyD family protein
JH254_04545	COG0114	fumarate hydratase activity
JH254_04555	COG0506	proline dehydrogenase activity
JH254_04555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JH254_04555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JH254_04560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JH254_04575	COG0737	Belongs to the 5'-nucleotidase family
JH254_04595	COG2204	response regulator
JH254_04600	COG0545	Peptidyl-prolyl cis-trans isomerase
JH254_04610	COG2900	Belongs to the SlyX family
JH254_04615	COG1047	Peptidyl-prolyl cis-trans
JH254_04620	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JH254_04630	COG0835	chemotaxis
JH254_04630	COG0784	Response regulator, receiver
JH254_04635	COG0429	hydrolase of the alpha beta-hydrolase fold
JH254_04640	COG2203	Gaf domain
JH254_04640	COG3706	GGDEF domain
JH254_04640	COG4251	negative regulation of phosphorylation
JH254_04640	COG5001	Diguanylate cyclase
JH254_04645	COG3089	Belongs to the UPF0270 family
JH254_04650	COG3954	Phosphoribulokinase
JH254_04665	COG1765	OsmC-like protein
JH254_04675	COG2226	methyltransferase
JH254_04685	COG2202	Pas domain
JH254_04685	COG2205	protein histidine kinase activity
JH254_04690	COG2814	Major facilitator Superfamily
JH254_04715	COG0748	coenzyme F420 binding
JH254_04720	COG3721	Heme iron utilization protein
JH254_04730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JH254_04755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JH254_04765	COG0463	Glycosyl transferase, family 2
JH254_04770	COG0739	heme binding
JH254_04770	COG1196	nuclear chromosome segregation
JH254_04770	COG0741	lytic transglycosylase activity
JH254_04775	COG0488	(ABC) transporter
JH254_04785	COG2252	PERMEase
JH254_04790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JH254_04795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JH254_04800	COG3178	'Phosphotransferase
JH254_04805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JH254_04815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JH254_04820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JH254_04825	COG2967	ApaG domain
JH254_04830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JH254_04840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JH254_04845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JH254_04850	COG3314	Sporulation integral membrane protein YlbJ
JH254_04855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JH254_04860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JH254_04865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JH254_04870	COG0142	geranyltranstransferase activity
JH254_04875	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JH254_04880	COG0330	HflC and HflK could
JH254_04885	COG0330	HflC and HflK could
JH254_04890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JH254_04895	COG1923	regulation of RNA biosynthetic process
JH254_04900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JH254_04905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JH254_04915	COG0802	atpase or kinase
JH254_04920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JH254_04920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JH254_04940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JH254_04945	COG2011	ABC-type metal ion transport system permease component
JH254_04950	COG1464	Belongs to the NlpA lipoprotein family
JH254_04970	COG2205	protein histidine kinase activity
JH254_04970	COG0784	Response regulator, receiver
JH254_04985	COG5002	protein histidine kinase activity
JH254_04985	COG2198	Histidine kinase
JH254_04985	COG0784	Response regulator, receiver
JH254_05005	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JH254_05020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JH254_05025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JH254_05030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JH254_05035	COG2716	regulation of RNA biosynthetic process
JH254_05040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JH254_05045	COG3013	Belongs to the UPF0304 family
JH254_05055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JH254_05060	COG0280	phosphate acetyltransferase
JH254_05060	COG0857	belongs to the CobB CobQ family
JH254_05065	COG0440	acetolactate synthase activity
JH254_05070	COG0028	Belongs to the TPP enzyme family
JH254_05085	COG0671	phosphoesterase, PA-phosphatase related
JH254_05095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JH254_05100	COG0473	3-isopropylmalate dehydrogenase activity
JH254_05105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JH254_05110	COG0066	3-isopropylmalate dehydratase activity
JH254_05125	COG4143	(ABC) transporter
JH254_05130	COG1178	ABC-type Fe3 transport system permease component
JH254_05135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JH254_05145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JH254_05185	COG0848	biopolymer transport protein
JH254_05190	COG0811	peptide transport
JH254_05195	COG0811	peptide transport
JH254_05205	COG4206	TonB-dependent receptor
JH254_05210	COG4174	ABC transporter (Permease)
JH254_05215	COG4239	(ABC) transporter, permease
JH254_05225	COG0444	Belongs to the ABC transporter superfamily
JH254_05230	COG4608	Belongs to the ABC transporter superfamily
JH254_05235	COG2195	Cleaves the N-terminal amino acid of tripeptides
JH254_05240	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JH254_05245	COG1073	alpha beta
JH254_05260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JH254_05285	COG0243	molybdopterin cofactor binding
JH254_05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JH254_05290	COG1648	precorrin-2 dehydrogenase activity
JH254_05300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JH254_05300	COG1116	anion transmembrane transporter activity
JH254_05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JH254_05310	COG1116	anion transmembrane transporter activity
JH254_05315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JH254_05315	COG2146	nitrite reductase [NAD(P)H] activity
JH254_05320	COG2146	nitrite reductase [NAD(P)H] activity
JH254_05320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JH254_05325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH254_05330	COG2313	pseudouridylate synthase activity
JH254_05350	COG0521	Mo-molybdopterin cofactor biosynthetic process
JH254_05365	COG2966	Psort location CytoplasmicMembrane, score
JH254_05370	COG3610	response to peptide
JH254_05380	COG4175	Glycine betaine
JH254_05385	COG4176	ABC-type proline glycine betaine transport system permease component
JH254_05390	COG2113	Glycine betaine
JH254_05395	COG0175	sulfate reduction
JH254_05400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JH254_05405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JH254_05410	COG0384	phenazine biosynthesis protein PhzF
JH254_05415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JH254_05430	COG0786	glutamate:sodium symporter activity
JH254_05435	COG0252	asparaginase activity
JH254_05440	COG3139	Protein of unknown function (DUF1315)
JH254_05460	COG0616	signal peptide processing
JH254_05465	COG0446	pyridine nucleotide-disulphide oxidoreductase
JH254_05465	COG1902	pentaerythritol trinitrate reductase activity
JH254_05470	COG0778	Nitroreductase
JH254_05480	COG0110	maltose O-acetyltransferase activity
JH254_05485	COG2264	protein methyltransferase activity
JH254_05490	COG0604	alcohol dehydrogenase
JH254_05495	COG0583	DNA-binding transcription factor activity
JH254_05500	COG1263	PTS System
JH254_05500	COG2190	(PTS) system
JH254_05500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JH254_05505	COG4145	pantothenate transmembrane transporter activity
JH254_05510	COG3924	membrane
JH254_05515	COG0439	Biotin carboxylase
JH254_05520	COG0511	ligase activity, forming carbon-carbon bonds
JH254_05525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JH254_05530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JH254_05545	COG3381	protein complex oligomerization
JH254_05555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JH254_05565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JH254_05570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JH254_05570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JH254_05585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JH254_05590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JH254_05595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JH254_05600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JH254_05605	COG4172	Belongs to the ABC transporter superfamily
JH254_05615	COG0601	transmembrane transport
JH254_05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JH254_05625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JH254_05630	COG0142	geranyltranstransferase activity
JH254_05635	COG1722	exodeoxyribonuclease VII activity
JH254_05640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JH254_05645	COG1360	Flagellar Motor Protein
JH254_05660	COG1534	Rna-binding protein
JH254_05665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JH254_05675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JH254_05680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JH254_05685	COG0149	triose-phosphate isomerase activity
JH254_05690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JH254_05705	COG0779	Required for maturation of 30S ribosomal subunits
JH254_05710	COG0195	Participates in both transcription termination and antitermination
JH254_05715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JH254_05720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JH254_05725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JH254_05730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JH254_05735	COG1185	polyribonucleotide nucleotidyltransferase activity
JH254_05740	COG2211	Major facilitator Superfamily
JH254_05745	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JH254_05750	COG1422	Protein of unknown function (DUF1090)
JH254_05755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JH254_05760	COG0826	peptidase U32
JH254_05775	COG0312	modulator of DNA gyrase
JH254_05780	COG0312	modulator of DNA gyrase
JH254_05790	COG4974	Belongs to the 'phage' integrase family
JH254_05795	COG1970	mechanosensitive ion channel activity
JH254_05810	COG0789	Transcriptional regulator
JH254_05825	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JH254_05835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JH254_05840	COG0321	lipoyl(octanoyl) transferase activity
JH254_05845	COG2921	Belongs to the UPF0250 family
JH254_05850	COG1686	Belongs to the peptidase S11 family
JH254_05855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JH254_05860	COG2951	lytic endotransglycosylase activity
JH254_05865	COG0772	Belongs to the SEDS family
JH254_05870	COG0768	penicillin binding
JH254_05875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JH254_05880	COG0799	negative regulation of ribosome biogenesis
JH254_05885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JH254_05905	COG0366	Alpha amylase catalytic
JH254_05920	COG0443	Heat shock 70 kDa protein
JH254_05925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JH254_05930	COG3045	CreA protein
JH254_05950	COG0174	glutamine synthetase
JH254_05970	COG3842	ATPase activity
JH254_05975	COG1176	ABC-type spermidine putrescine transport system, permease component I
JH254_05980	COG1177	transmembrane transport
JH254_05985	COG2258	MOSC domain
JH254_06000	COG2050	protein possibly involved in aromatic compounds catabolism
JH254_06005	COG0514	ATP-dependent DNA helicase (RecQ)
JH254_06015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JH254_06025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JH254_06030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JH254_06035	COG2239	Acts as a magnesium transporter
JH254_06040	COG1648	precorrin-2 dehydrogenase activity
JH254_06040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JH254_06045	COG2116	formate transmembrane transporter activity
JH254_06055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JH254_06060	COG0842	Transport permease protein
JH254_06065	COG0842	Transport permease protein
JH254_06070	COG1131	(ABC) transporter
JH254_06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_06095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JH254_06100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JH254_06120	COG1595	DNA-templated transcription, initiation
JH254_06125	COG3806	Anti-sigma factor
JH254_06130	COG1968	undecaprenyl-diphosphatase activity
JH254_06135	COG0667	Aldo Keto reductase
JH254_06140	COG2017	converts alpha-aldose to the beta-anomer
JH254_06145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JH254_06155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JH254_06160	COG1609	Transcriptional regulator
JH254_06165	COG3250	beta-galactosidase activity
JH254_06205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JH254_06210	COG1288	antiporter activity
JH254_06215	COG1438	arginine binding
JH254_06220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JH254_06225	COG0540	Belongs to the ATCase OTCase family
JH254_06250	COG0840	transmembrane signaling receptor activity
JH254_06260	COG3040	lipid binding
JH254_06265	COG2207	Transcriptional regulator
JH254_06270	COG1979	alcohol dehydrogenase
JH254_06275	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JH254_06280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JH254_06285	COG2964	Protein conserved in bacteria
JH254_06290	COG3681	Belongs to the UPF0597 family
JH254_06295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH254_06300	COG0564	pseudouridine synthase activity
JH254_06310	COG0542	response to heat
JH254_06315	COG0583	DNA-binding transcription factor activity
JH254_06330	COG2502	aspartate--ammonia ligase
JH254_06335	COG1522	sequence-specific DNA binding
JH254_06365	COG2205	protein histidine kinase activity
JH254_06375	COG2204	response regulator
JH254_06385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JH254_06420	COG0243	molybdopterin cofactor binding
JH254_06425	COG3005	denitrification pathway
JH254_06430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JH254_06435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JH254_06440	COG0569	domain protein
JH254_06445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JH254_06470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JH254_06485	COG0250	Participates in transcription elongation, termination and antitermination
JH254_06490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JH254_06495	COG0081	regulation of translation
JH254_06500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JH254_06505	COG0222	ribosome binding
JH254_06510	COG0085	RNA polymerase activity
JH254_06515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JH254_06520	COG2964	Protein conserved in bacteria
JH254_06525	COG0251	oxidation-reduction process
JH254_06530	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JH254_06540	COG2168	tRNA wobble position uridine thiolation
JH254_06545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JH254_06550	COG0049	tRNA binding
JH254_06555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JH254_06560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JH254_06565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JH254_06600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JH254_06605	COG0739	heme binding
JH254_06610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JH254_06615	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JH254_06615	COG3408	Glycogen debranching enzyme
JH254_06625	COG1881	PFAM PEBP family protein
JH254_06630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JH254_06635	COG0583	DNA-binding transcription factor activity
JH254_06645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JH254_06655	COG0583	DNA-binding transcription factor activity
JH254_06660	COG1028	Short-chain dehydrogenase reductase Sdr
JH254_06665	COG0616	signal peptide processing
JH254_06670	COG3724	N-succinylarginine dihydrolase activity
JH254_06690	COG0840	transmembrane signaling receptor activity
JH254_06700	COG2971	BadF BadG BcrA BcrD
JH254_06710	COG4608	Belongs to the ABC transporter superfamily
JH254_06715	COG0444	Belongs to the ABC transporter superfamily
JH254_06720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JH254_06735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JH254_06745	COG0640	Transcriptional regulator
JH254_06750	COG0798	PFAM Bile acid sodium symporter
JH254_06755	COG1393	Belongs to the ArsC family
JH254_06770	COG1677	Flagellar hook-basal body complex protein FliE
JH254_06780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JH254_06835	COG1684	flagellar biosynthetic protein fliR
JH254_06845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JH254_06870	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JH254_06875	COG2198	Histidine kinase
JH254_06875	COG0784	Response regulator, receiver
JH254_06875	COG0643	Histidine kinase
JH254_06885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JH254_06890	COG1360	Flagellar Motor Protein
JH254_06895	COG1192	Involved in chromosome partitioning
JH254_06905	COG0835	chemotaxis
JH254_06920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JH254_06925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JH254_06930	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JH254_06935	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JH254_06940	COG1138	Cytochrome C-type biogenesis protein
JH254_06945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH254_06955	COG0457	Tetratricopeptide repeat
JH254_06970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JH254_06975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JH254_06975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JH254_06990	COG0259	pyridoxamine-phosphate oxidase activity
JH254_07020	COG3153	acetyltransferase
JH254_07050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JH254_07055	COG2867	negative regulation of translational initiation
JH254_07060	COG2914	Belongs to the UPF0125 (RnfH) family
JH254_07065	COG0702	epimerase
JH254_07070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH254_07075	COG1454	alcohol dehydrogenase
JH254_07085	COG0564	pseudouridine synthase activity
JH254_07090	COG1957	nucleoside hydrolase
JH254_07115	COG1280	lysine exporter protein (LysE YggA)
JH254_07125	COG3263	regulation of cellular component size
JH254_07135	COG1876	peptidase activity
JH254_07140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JH254_07145	COG1393	Belongs to the ArsC family
JH254_07150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_07165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_07185	COG3069	C4-dicarboxylate transmembrane transporter activity
JH254_07190	COG1473	amidohydrolase
JH254_07200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JH254_07205	COG0017	Asparaginyl-tRNA synthetase
JH254_07225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JH254_07230	COG0156	8-amino-7-oxononanoate synthase activity
JH254_07235	COG2226	methyltransferase
JH254_07235	COG1073	alpha beta
JH254_07240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JH254_07245	COG0501	Belongs to the peptidase M48B family
JH254_07250	COG3217	Mosc domain protein beta barrel domain protein
JH254_07250	COG0633	Ferredoxin
JH254_07250	COG3217	Mosc domain protein beta barrel domain protein
JH254_07250	COG0633	Ferredoxin
JH254_07260	COG1013	pyruvate-flavodoxin oxidoreductase activity
JH254_07260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JH254_07260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JH254_07260	COG0674	pyruvate-flavodoxin oxidoreductase activity
JH254_07295	COG4651	solute:proton antiporter activity
JH254_07295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JH254_07300	COG0405	Gamma-glutamyltransferase
JH254_07310	COG2974	May be involved in recombination
JH254_07315	COG1247	-acetyltransferase
JH254_07320	COG0420	3'-5' exonuclease activity
JH254_07330	COG3038	cytochrome b561
JH254_07335	COG2190	(PTS) system
JH254_07345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_07350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JH254_07355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JH254_07370	COG1720	tRNA m6t6A37 methyltransferase activity
JH254_07390	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JH254_07395	COG4988	ABC transporter
JH254_07410	COG0745	RESPONSE REGULATOR receiver
JH254_07420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JH254_07435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JH254_07440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JH254_07450	COG0083	homoserine kinase activity
JH254_07455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JH254_07485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JH254_07525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JH254_07530	COG1289	transmembrane transporter activity
JH254_07535	COG1763	Mo-molybdopterin cofactor biosynthetic process
JH254_07540	COG0746	molybdenum cofactor guanylyltransferase activity
JH254_07545	COG0281	malic enzyme
JH254_07575	COG3264	Mechanosensitive ion channel
JH254_07575	COG1196	nuclear chromosome segregation
JH254_07585	COG2850	peptidyl-arginine hydroxylation
JH254_07590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JH254_07595	COG2915	High frequency lysogenization protein hflD homolog
JH254_07600	COG0482	sulfurtransferase activity
JH254_07610	COG1187	pseudouridine synthase activity
JH254_07615	COG0456	acetyltransferase
JH254_07655	COG0538	isocitrate dehydrogenase activity
JH254_07665	COG3048	D-serine ammonia-lyase activity
JH254_07670	COG0583	DNA-binding transcription factor activity
JH254_07675	COG2916	Histone family protein nucleoid-structuring protein H-NS
JH254_07680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JH254_07685	COG2375	cellular response to nickel ion
JH254_07690	COG1538	Outer membrane efflux protein
JH254_07695	COG1136	(ABC) transporter
JH254_07695	COG0577	efflux transmembrane transporter activity
JH254_07700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_07710	COG0497	DNA recombination
JH254_07715	COG3706	GGDEF domain
JH254_07720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JH254_07725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JH254_07730	COG0443	Heat shock 70 kDa protein
JH254_07735	COG0484	heat shock protein binding
JH254_07765	COG1285	pathogenesis
JH254_07775	COG0446	pyridine nucleotide-disulphide oxidoreductase
JH254_07815	COG0095	Lipoate-protein ligase
JH254_07830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH254_07835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_07845	COG0708	Exodeoxyribonuclease III
JH254_07855	COG0745	RESPONSE REGULATOR receiver
JH254_07860	COG0071	Belongs to the small heat shock protein (HSP20) family
JH254_07870	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JH254_07875	COG5433	transposase activity
JH254_07925	COG2983	Belongs to the UPF0260 family
JH254_07930	COG1882	Formate acetyltransferase
JH254_07935	COG2116	formate transmembrane transporter activity
JH254_07940	COG1944	ATP diphosphatase activity
JH254_07955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JH254_07960	COG1278	Cold shock
JH254_07965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JH254_07970	COG0542	response to heat
JH254_07975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JH254_07980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JH254_07985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JH254_07990	COG3134	Outer membrane lipoprotein
JH254_07995	COG3706	GGDEF domain
JH254_08000	COG0492	ferredoxin-NADP+ reductase activity
JH254_08005	COG0686	Belongs to the AlaDH PNT family
JH254_08015	COG1674	ftsk spoiiie
JH254_08015	COG0531	amino acid
JH254_08020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JH254_08025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JH254_08030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JH254_08035	COG1286	toxin biosynthetic process
JH254_08040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JH254_08045	COG2723	6-phospho-beta-galactosidase activity
JH254_08050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JH254_08050	COG1263	PTS System
JH254_08055	COG1609	Transcriptional regulator
JH254_08065	COG4172	Belongs to the ABC transporter superfamily
JH254_08075	COG4171	peptide transport system, permease
JH254_08090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JH254_08095	COG1842	Phage shock protein A
JH254_08110	COG3106	COG3106 Predicted ATPase
JH254_08115	COG3768	UPF0283 membrane protein
JH254_08125	COG2154	pterin-4-alpha-carbinolamine dehydratase
JH254_08145	COG2885	chlorophyll binding
JH254_08155	COG1570	exodeoxyribonuclease VII activity
JH254_08165	COG0366	Alpha amylase catalytic
JH254_08165	COG1874	Beta-galactosidase
JH254_08175	COG0517	IMP dehydrogenase activity
JH254_08175	COG0516	GMP reductase activity
JH254_08180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JH254_08180	COG0519	Catalyzes the synthesis of GMP from XMP
JH254_08220	COG1846	Transcriptional regulator
JH254_08230	COG0500	methyltransferase
JH254_08240	COG2062	phosphohistidine phosphatase, SixA
JH254_08250	COG0697	spore germination
JH254_08265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JH254_08270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JH254_08280	COG4591	ABC-type transport system involved in lipoprotein release permease component
JH254_08285	COG1136	(ABC) transporter
JH254_08290	COG4591	ABC-type transport system involved in lipoprotein release permease component
JH254_08295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JH254_08305	COG0544	peptidyl-prolyl cis-trans isomerase activity
JH254_08310	COG0740	serine-type endopeptidase activity
JH254_08315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JH254_08320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JH254_08325	COG0776	regulation of translation
JH254_08330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JH254_08335	COG0488	(ABC) transporter
JH254_08340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JH254_08345	COG3162	membrane
JH254_08360	COG1024	Enoyl-CoA hydratase
JH254_08365	COG1115	amino acid carrier protein
JH254_08375	COG3228	Belongs to the MtfA family
JH254_08380	COG1584	GPR1 FUN34 yaaH family protein
JH254_08405	COG1024	Enoyl-CoA hydratase
JH254_08410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JH254_08415	COG1960	acyl-CoA dehydrogenase activity
JH254_08425	COG1960	acyl-CoA dehydrogenase activity
JH254_08430	COG1024	Enoyl-CoA hydratase
JH254_08435	COG1024	Enoyl-CoA hydratase
JH254_08445	COG1028	Short-chain dehydrogenase reductase Sdr
JH254_08455	COG0730	response to heat
JH254_08490	COG5433	transposase activity
JH254_08495	COG3039	Transposase
JH254_08515	COG1530	ribonuclease E activity
JH254_08520	COG0564	pseudouridine synthase activity
JH254_08535	COG1399	metal-binding, possibly nucleic acid-binding protein
JH254_08540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JH254_08545	COG0416	fatty acid biosynthetic process
JH254_08550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JH254_08560	COG1028	Short-chain dehydrogenase reductase Sdr
JH254_08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JH254_08570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JH254_08575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JH254_08580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JH254_08585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JH254_08590	COG0470	DNA polymerase III
JH254_08595	COG0084	hydrolase, TatD family'
JH254_08610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JH254_08610	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JH254_08615	COG3008	intermembrane lipid transfer
JH254_08620	COG2995	paraquat-inducible protein a
JH254_08630	COG3141	response to X-ray
JH254_08640	COG1067	ATP-dependent peptidase activity
JH254_08645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JH254_08660	COG0488	(ABC) transporter
JH254_08670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JH254_08670	COG0116	Belongs to the methyltransferase superfamily
JH254_08680	COG0167	dihydroorotate dehydrogenase activity
JH254_08685	COG2902	Dehydrogenase
JH254_08695	COG0308	aminopeptidase N
JH254_08705	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JH254_08710	COG1956	GAF domain-containing protein
JH254_08720	COG3278	Belongs to the heme-copper respiratory oxidase family
JH254_08735	COG2010	Cytochrome c
JH254_08745	COG2217	Heavy metal translocating P-type atpase
JH254_08760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JH254_08765	COG0589	response to stress
JH254_08770	COG0037	tRNA processing
JH254_08785	COG0625	glutathione transferase activity
JH254_08790	COG1869	D-ribose catabolic process
JH254_08795	COG1129	ABC transporter
JH254_08800	COG1172	Belongs to the binding-protein-dependent transport system permease family
JH254_08805	COG1879	ABC-type sugar transport system periplasmic component
JH254_08810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH254_08815	COG1609	Transcriptional regulator
JH254_08850	COG0776	regulation of translation
JH254_08855	COG0072	phenylalanine-tRNA ligase activity
JH254_08855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JH254_08860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JH254_08865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JH254_08870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JH254_08875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JH254_08880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JH254_08910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JH254_08920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JH254_08925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JH254_08930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JH254_08935	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JH254_08940	COG3313	Fe-S protein
JH254_08945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JH254_08945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JH254_08945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JH254_08950	COG1105	Belongs to the carbohydrate kinase PfkB family
JH254_08955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_08955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH254_08960	COG1609	Transcriptional regulator
JH254_08965	COG0814	amino acid
JH254_08975	COG5654	RES domain protein
JH254_08980	COG0513	Belongs to the DEAD box helicase family
JH254_08990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JH254_08995	COG2890	protein-(glutamine-N5) methyltransferase activity
JH254_09000	COG2840	Smr protein MutS2
JH254_09035	COG2824	Alkylphosphonate utilization operon protein PhnA
JH254_09050	COG0154	amidase activity
JH254_09055	COG2957	Belongs to the agmatine deiminase family
JH254_09070	COG1902	pentaerythritol trinitrate reductase activity
JH254_09085	COG0456	acetyltransferase
JH254_09105	COG5002	protein histidine kinase activity
JH254_09105	COG5001	Diguanylate cyclase
JH254_09110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JH254_09125	COG0456	acetyltransferase
JH254_09135	COG1022	Amp-dependent synthetase and ligase
JH254_09145	COG1794	racemase activity, acting on amino acids and derivatives
JH254_09160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JH254_09175	COG0733	neurotransmitter:sodium symporter activity
JH254_09180	COG0733	neurotransmitter:sodium symporter activity
JH254_09195	COG0561	phosphatase activity
JH254_09225	COG1846	Transcriptional regulator
JH254_09230	COG2130	NADP-dependent
JH254_09260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JH254_09265	COG1640	4-alpha-glucanotransferase
JH254_09270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JH254_09280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JH254_09285	COG0840	transmembrane signaling receptor activity
JH254_09360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JH254_09365	COG2885	chlorophyll binding
JH254_09370	COG0823	Involved in the tonB-independent uptake of proteins
JH254_09385	COG0811	peptide transport
JH254_09390	COG0824	Thioesterase
JH254_09395	COG3790	cyd operon protein YbgE
JH254_09400	COG4890	Cyd operon protein YbgT
JH254_09405	COG1294	oxidase, subunit
JH254_09410	COG1271	oxidase subunit
JH254_09420	COG2255	four-way junction helicase activity
JH254_09425	COG0632	four-way junction helicase activity
JH254_09430	COG0840	transmembrane signaling receptor activity
JH254_09435	COG0442	prolyl-tRNA aminoacylation
JH254_09440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JH254_09445	COG4221	oxidoreductase activity
JH254_09460	COG1024	Enoyl-CoA hydratase
JH254_09475	COG4166	transmembrane transport
JH254_09490	COG0513	Belongs to the DEAD box helicase family
JH254_09525	COG0457	Tetratricopeptide repeat
JH254_09525	COG3118	belongs to the thioredoxin family
JH254_09535	COG1215	transferase activity, transferring glycosyl groups
JH254_09555	COG2194	sulfuric ester hydrolase activity
JH254_09560	COG1448	Aminotransferase
JH254_09575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JH254_09580	COG1328	CTP reductase activity
JH254_09610	COG3397	chitin binding
JH254_09615	COG0583	DNA-binding transcription factor activity
JH254_09620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JH254_09625	COG4208	sulfate ABC transporter
JH254_09630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JH254_09640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JH254_09650	COG0675	Transposase, IS605 OrfB family
JH254_09655	COG2996	Protein conserved in bacteria
JH254_09670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JH254_09675	COG3099	Belongs to the UPF0263 family
JH254_09680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JH254_09685	COG2894	cell division
JH254_09690	COG0850	regulation of cytokinetic process
JH254_09695	COG3100	YcgL domain-containing protein
JH254_09700	COG2951	lytic endotransglycosylase activity
JH254_09705	COG1760	l-serine dehydratase
JH254_09710	COG1760	l-serine dehydratase
JH254_09715	COG3123	guanosine phosphorylase activity
JH254_09720	COG1301	dicarboxylic acid transport
JH254_09735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JH254_09740	COG2067	long-chain fatty acid transport protein
JH254_09745	COG2067	long-chain fatty acid transport protein
JH254_09755	COG1595	DNA-templated transcription, initiation
JH254_09785	COG0714	Associated with various cellular activities
JH254_09790	COG0183	Belongs to the thiolase family
JH254_09795	COG1024	Enoyl-CoA hydratase
JH254_09795	COG1250	3-hydroxyacyl-CoA dehydrogenase
JH254_09805	COG4681	YaeQ
JH254_09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JH254_09840	COG3134	Outer membrane lipoprotein
JH254_09855	COG0675	Transposase, IS605 OrfB family
JH254_09865	COG2378	regulation of single-species biofilm formation
JH254_09875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JH254_09875	COG0140	phosphoribosyl-ATP diphosphatase activity
JH254_09880	COG0107	imidazoleglycerol-phosphate synthase activity
JH254_09885	COG0784	Response regulator, receiver
JH254_09885	COG2198	Histidine kinase
JH254_09885	COG2205	protein histidine kinase activity
JH254_09890	COG2199	diguanylate cyclase activity
JH254_09895	COG3437	response regulator, receiver
JH254_09900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JH254_09905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JH254_09910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JH254_09910	COG0131	Imidazoleglycerol-phosphate dehydratase
JH254_09915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JH254_09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JH254_09925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JH254_09935	COG1199	ATP-dependent helicase activity
JH254_09940	COG1214	PFAM Peptidase M22, glycoprotease
JH254_09950	COG0596	Alpha beta hydrolase
JH254_09955	COG0318	PFAM AMP-dependent synthetase and ligase
JH254_09970	COG0697	spore germination
JH254_09980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JH254_09985	COG2832	Protein of unknown function (DUF454)
JH254_09990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JH254_10000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JH254_10005	COG0583	DNA-binding transcription factor activity
JH254_10015	COG3314	Sporulation integral membrane protein YlbJ
JH254_10020	COG2197	response regulator
JH254_10025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JH254_10025	COG0617	tRNA 3'-terminal CCA addition
JH254_10025	COG0517	IMP dehydrogenase activity
JH254_10030	COG1643	Atp-dependent helicase
JH254_10040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JH254_10050	COG3437	response regulator, receiver
JH254_10055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JH254_10060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JH254_10065	COG0709	Synthesizes selenophosphate from selenide and ATP
JH254_10080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JH254_10085	COG0840	transmembrane signaling receptor activity
JH254_10090	COG1254	Belongs to the acylphosphatase family
JH254_10100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JH254_10100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JH254_10105	COG0489	protein tyrosine kinase activity
JH254_10110	COG0572	uridine kinase
JH254_10115	COG0717	Belongs to the dCTP deaminase family
JH254_10120	COG0306	phosphate transporter
JH254_10130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JH254_10140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JH254_10155	COG0346	lactoylglutathione lyase activity
JH254_10160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JH254_10165	COG4660	Part of a membrane complex involved in electron transport
JH254_10170	COG4659	FMN binding
JH254_10175	COG4658	electron transport chain
JH254_10185	COG2878	Part of a membrane complex involved in electron transport
JH254_10190	COG4657	Part of a membrane complex involved in electron transport
JH254_10195	COG0697	spore germination
JH254_10215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JH254_10220	COG1288	antiporter activity
JH254_10225	COG0436	Aminotransferase
JH254_10235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JH254_10240	COG2027	D-alanyl-D-alanine carboxypeptidase
JH254_10245	COG1061	Type III restriction enzyme res subunit
JH254_10250	COG1566	PFAM secretion protein HlyD family protein
JH254_10265	COG3264	Mechanosensitive ion channel
JH254_10265	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JH254_10270	COG1966	Carbon starvation protein
JH254_10275	COG3279	Response regulator of the LytR AlgR family
JH254_10280	COG3275	phosphorelay sensor kinase activity
JH254_10290	COG1012	belongs to the aldehyde dehydrogenase family
JH254_10290	COG1454	alcohol dehydrogenase
JH254_10295	COG2095	MarC family integral membrane protein
JH254_10305	COG0601	transmembrane transport
JH254_10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JH254_10315	COG0444	Belongs to the ABC transporter superfamily
JH254_10325	COG0861	Integral membrane protein TerC family
JH254_10330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JH254_10340	COG1301	dicarboxylic acid transport
JH254_10360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JH254_10375	COG0537	adenosine 5'-monophosphoramidase activity
JH254_10410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JH254_10415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JH254_10430	COG2354	Protein conserved in bacteria
JH254_10435	COG1164	Oligoendopeptidase f
JH254_10440	COG1164	Oligoendopeptidase f
JH254_10445	COG3150	esterase
JH254_10450	COG1252	NADH dehydrogenase
JH254_10460	COG0393	Putative heavy-metal-binding
JH254_10465	COG1368	sulfuric ester hydrolase activity
JH254_10475	COG0527	aspartate kinase activity
JH254_10480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JH254_10480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JH254_10485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JH254_10520	COG0583	DNA-binding transcription factor activity
JH254_10525	COG1620	l-lactate permease
JH254_10530	COG0247	lactate metabolic process
JH254_10535	COG1139	Iron-sulfur cluster binding protein
JH254_10555	COG2801	Transposase and inactivated derivatives
JH254_10560	COG3039	Transposase
JH254_10610	COG2249	NAD(P)H dehydrogenase (quinone) activity
JH254_10615	COG0583	DNA-binding transcription factor activity
JH254_10620	COG4221	oxidoreductase activity
JH254_10635	COG1770	oligopeptidase
JH254_10640	COG2358	TRAP transporter, solute receptor (TAXI family
JH254_10655	COG3714	YhhN family
JH254_10670	COG0583	DNA-binding transcription factor activity
JH254_10680	COG1301	dicarboxylic acid transport
JH254_10690	COG2095	MarC family integral membrane protein
JH254_10700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JH254_10710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JH254_10720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH254_10745	COG0742	ribosomal rna small subunit methyltransferase
JH254_10750	COG0552	protein localization to endoplasmic reticulum
JH254_10755	COG2884	Cell division ATP-binding protein ftsE
JH254_10760	COG2177	Part of the ABC transporter FtsEX involved in
JH254_10770	COG0288	reversible hydration of carbon dioxide
JH254_10775	COG2188	Transcriptional regulator
JH254_10780	COG1228	amidohydrolase
JH254_10785	COG0010	Belongs to the arginase family
JH254_10790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JH254_10795	COG2986	histidine ammonia-lyase
JH254_10800	COG0387	Pfam Sodium calcium exchanger
JH254_10805	COG2200	EAL domain
JH254_10860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JH254_10865	COG1459	type II secretion system
JH254_10880	COG4969	Belongs to the N-Me-Phe pilin family
JH254_10885	COG4968	Prepilin-type N-terminal cleavage methylation domain
JH254_10910	COG1077	Cell shape determining protein MreB Mrl
JH254_10915	COG1792	Involved in formation and maintenance of cell shape
JH254_10920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JH254_10925	COG0424	maF-like protein
JH254_10930	COG1530	ribonuclease E activity
JH254_10935	COG3164	Protein of unknown function
JH254_10940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JH254_10945	COG0312	modulator of DNA gyrase
JH254_10960	COG0477	Major facilitator Superfamily
JH254_10970	COG2321	neutral zinc metallopeptidase
JH254_11005	COG0189	ligase activity
JH254_11010	COG0642	Histidine kinase
JH254_11015	COG0745	RESPONSE REGULATOR receiver
JH254_11030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JH254_11035	COG0352	thiamine-phosphate diphosphorylase activity
JH254_11040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JH254_11050	COG2022	thiamine diphosphate biosynthetic process
JH254_11055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JH254_11075	COG1113	amino acid transport
JH254_11085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JH254_11090	COG0574	Belongs to the PEP-utilizing enzyme family
JH254_11090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JH254_11120	COG1464	Belongs to the NlpA lipoprotein family
JH254_11130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JH254_11135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JH254_11145	COG0101	tRNA pseudouridine synthase activity
JH254_11150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JH254_11155	COG0285	dihydrofolate synthase activity
JH254_11160	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JH254_11165	COG2920	part of a sulfur-relay system
JH254_11170	COG1289	transmembrane transporter activity
JH254_11175	COG0670	Belongs to the BI1 family
JH254_11210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JH254_11220	COG3706	GGDEF domain
JH254_11225	COG0564	pseudouridine synthase activity
JH254_11240	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JH254_11250	COG0625	glutathione transferase activity
JH254_11265	COG0367	asparagine synthase
JH254_11275	COG0647	UMP catabolic process
JH254_11280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JH254_11290	COG1902	pentaerythritol trinitrate reductase activity
JH254_11295	COG1253	flavin adenine dinucleotide binding
JH254_11305	COG0277	FAD linked oxidase domain protein
JH254_11305	COG0247	lactate metabolic process
JH254_11315	COG2050	protein possibly involved in aromatic compounds catabolism
JH254_11335	COG0583	DNA-binding transcription factor activity
JH254_11340	COG2814	Major facilitator Superfamily
JH254_11345	COG2056	Na+-H+ antiporter family
JH254_11350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JH254_11365	COG0483	inositol monophosphate 1-phosphatase activity
JH254_11375	COG0625	glutathione transferase activity
JH254_11380	COG0625	glutathione transferase activity
JH254_11390	COG0601	transmembrane transport
JH254_11395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JH254_11400	COG0444	Belongs to the ABC transporter superfamily
JH254_11405	COG2814	Major facilitator Superfamily
JH254_11425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH254_11430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH254_11435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JH254_11440	COG0509	glycine decarboxylation via glycine cleavage system
JH254_11445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JH254_11445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JH254_11465	COG0477	Major facilitator Superfamily
JH254_11470	COG3385	transposase activity
JH254_11475	COG3634	alkyl hydroperoxide reductase activity
JH254_11480	COG0450	alkyl hydroperoxide reductase
JH254_11485	COG0517	IMP dehydrogenase activity
JH254_11490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JH254_11495	COG0343	queuine tRNA-ribosyltransferase activity
JH254_11500	COG1862	Preprotein translocase
JH254_11505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JH254_11510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JH254_11515	COG2897	thiosulfate sulfurtransferase activity
JH254_11525	COG0826	peptidase U32
JH254_11530	COG0826	peptidase U32
JH254_11535	COG3154	lipid carrier protein
JH254_11550	COG1104	cysteine desulfurase activity
JH254_11555	COG0822	iron-sulfur transferase activity
JH254_11565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JH254_11570	COG0443	Heat shock 70 kDa protein
JH254_11575	COG0633	Ferredoxin
JH254_11585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JH254_11590	COG0105	UTP biosynthetic process
JH254_11595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JH254_11605	COG1426	Protein conserved in bacteria
JH254_11615	COG0124	histidyl-tRNA synthetase
JH254_11620	COG2976	Protein conserved in bacteria
JH254_11625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH254_11630	COG1160	GTP binding
JH254_11635	COG1645	bacterial-type flagellum-dependent swarming motility
JH254_11640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JH254_11645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JH254_11645	COG0047	phosphoribosylformylglycinamidine synthase activity
JH254_11650	COG1007	ATP synthesis coupled electron transport
JH254_11655	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH254_11665	COG0713	ATP synthesis coupled electron transport
JH254_11670	COG0839	Belongs to the complex I subunit 6 family
JH254_11675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH254_11680	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JH254_11685	COG1034	ATP synthesis coupled electron transport
JH254_11700	COG0649	NAD binding
JH254_11700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH254_11705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH254_11710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH254_11715	COG1360	Flagellar Motor Protein
JH254_11720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JH254_11730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_11760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JH254_11780	COG0724	RNA recognition motif
JH254_11785	COG4989	oxidoreductase activity
JH254_11810	COG0745	RESPONSE REGULATOR receiver
JH254_11815	COG0583	DNA-binding transcription factor activity
JH254_11825	COG5001	Diguanylate cyclase
JH254_11825	COG3300	MHYT domain
JH254_11830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JH254_11860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JH254_11865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JH254_11870	COG0539	negative regulation of cytoplasmic translation
JH254_11875	COG0776	regulation of translation
JH254_11885	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JH254_11905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JH254_11910	COG0602	queuosine metabolic process
JH254_11915	COG3530	Putative quorum-sensing-regulated virulence factor
JH254_11920	COG2096	Adenosyltransferase
JH254_11925	COG2916	Histone family protein nucleoid-structuring protein H-NS
JH254_11935	COG0247	lactate metabolic process
JH254_11945	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JH254_11950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JH254_11955	COG3012	SEC-C Motif Domain Protein
JH254_11960	COG0840	transmembrane signaling receptor activity
JH254_11965	COG1940	carbohydrate kinase activity
JH254_11965	COG1846	Transcriptional regulator
JH254_11970	COG3290	protein histidine kinase activity
JH254_11975	COG4565	transcriptional regulatory protein
JH254_11990	COG3181	Tripartite tricarboxylate transporter family receptor
JH254_12000	COG2985	domain, Protein
JH254_12000	COG0569	domain protein
JH254_12010	COG0556	nucleotide-excision repair
JH254_12020	COG0586	Pfam SNARE associated Golgi protein
JH254_12025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JH254_12030	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JH254_12035	COG2186	Transcriptional regulator
JH254_12040	COG2719	SpoVR family
JH254_12045	COG2718	Belongs to the UPF0229 family
JH254_12050	COG2766	serine protein kinase
JH254_12055	COG0514	ATP-dependent DNA helicase (RecQ)
JH254_12060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JH254_12065	COG0814	amino acid
JH254_12100	COG0058	SHG alpha-glucan phosphorylase activity
JH254_12110	COG0471	metal ion transport
JH254_12115	COG3118	belongs to the thioredoxin family
JH254_12125	COG1132	(ABC) transporter
JH254_12130	COG1132	(ABC) transporter
JH254_12145	COG2501	S4 domain
JH254_12155	COG3243	poly(R)-hydroxyalkanoic acid synthase
JH254_12175	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JH254_12180	COG2329	Antibiotic biosynthesis monooxygenase
JH254_12205	COG1742	UPF0060 membrane protein
JH254_12225	COG0513	Belongs to the DEAD box helicase family
JH254_12230	COG0386	Belongs to the glutathione peroxidase family
JH254_12240	COG1181	Belongs to the D-alanine--D-alanine ligase family
JH254_12245	COG3148	PFAM DTW domain containing protein
JH254_12265	COG0730	response to heat
JH254_12270	COG0583	DNA-binding transcription factor activity
JH254_12285	COG3593	DNA synthesis involved in DNA repair
JH254_12310	COG1846	Transcriptional regulator
JH254_12330	COG0583	DNA-binding transcription factor activity
JH254_12335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JH254_12340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JH254_12345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JH254_12350	COG1845	cytochrome c oxidase, subunit III
JH254_12355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JH254_12360	COG0109	protoheme IX farnesyltransferase activity
JH254_12365	COG2814	Major facilitator Superfamily
JH254_12370	COG5507	3-demethylubiquinone-9 3-methyltransferase
JH254_12375	COG2175	clavaminate synthase activity
JH254_12380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JH254_12385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JH254_12390	COG4521	taurine ABC transporter
JH254_12420	COG3550	peptidyl-serine autophosphorylation
JH254_12425	COG1396	sequence-specific DNA binding
JH254_12435	COG0159	tryptophan synthase activity
JH254_12440	COG0133	tryptophan synthase activity
JH254_12445	COG0134	indole-3-glycerol-phosphate synthase activity
JH254_12445	COG0135	phosphoribosylanthranilate isomerase activity
JH254_12450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JH254_12455	COG0512	Glutamine amidotransferase of anthranilate synthase
JH254_12455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JH254_12465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JH254_12470	COG0613	PHP domain protein
JH254_12475	COG0009	L-threonylcarbamoyladenylate synthase
JH254_12485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JH254_12495	COG1946	Acyl-CoA thioesterase
JH254_12510	COG1309	transcriptional regulator
JH254_12515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_12520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH254_12555	COG1484	DNA-dependent DNA replication
JH254_12560	COG4584	PFAM Integrase catalytic
JH254_12610	COG0659	secondary active sulfate transmembrane transporter activity
JH254_12625	COG2308	Evidence 4 Homologs of previously reported genes of
JH254_12660	COG0672	)-iron permease
JH254_12685	COG2814	Major facilitator Superfamily
JH254_12710	COG1136	(ABC) transporter
JH254_12715	COG0577	efflux transmembrane transporter activity
JH254_12735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JH254_12740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JH254_12740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JH254_12745	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JH254_12750	COG3074	FtsZ-dependent cytokinesis
JH254_12760	COG1045	serine acetyltransferase
JH254_12770	COG0745	RESPONSE REGULATOR receiver
JH254_12775	COG2205	protein histidine kinase activity
JH254_12780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JH254_12785	COG0534	Mate efflux family protein
JH254_12800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JH254_12805	COG2937	Belongs to the GPAT DAPAT family
JH254_12810	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JH254_12815	COG3161	chorismate lyase activity
JH254_12820	COG1580	Controls the rotational direction of flagella during chemotaxis
JH254_12850	COG3307	-O-antigen
JH254_12855	COG0438	transferase activity, transferring glycosyl groups
JH254_12860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JH254_12875	COG1063	alcohol dehydrogenase
JH254_12895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JH254_12900	COG2166	iron-sulfur cluster assembly
JH254_12905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JH254_12940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JH254_12945	COG0848	biopolymer transport protein
JH254_12950	COG0811	peptide transport
JH254_12955	COG0811	peptide transport
JH254_12965	COG2771	luxR family
JH254_12970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JH254_12975	COG1349	DNA-binding transcription factor activity
JH254_12980	COG0745	RESPONSE REGULATOR receiver
JH254_12985	COG2205	protein histidine kinase activity
JH254_12995	COG4452	Inner membrane protein CreD
JH254_13000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JH254_13005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JH254_13010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JH254_13015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JH254_13020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JH254_13025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JH254_13030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JH254_13040	COG0356	it plays a direct role in the translocation of protons across the membrane
JH254_13050	COG1475	DNA binding
JH254_13055	COG1192	Involved in chromosome partitioning
JH254_13060	COG0357	Ribosomal RNA small subunit methyltransferase G
JH254_13065	COG0445	tRNA wobble uridine modification
JH254_13070	COG0716	FMN binding
JH254_13075	COG4774	siderophore transport
JH254_13080	COG4615	Cyclic peptide transporter
JH254_13085	COG1120	ATPase activity
JH254_13090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JH254_13100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JH254_13105	COG0706	membrane insertase activity
JH254_13110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JH254_13115	COG0594	ribonuclease P activity
JH254_13120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JH254_13135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JH254_13150	COG1120	ATPase activity
JH254_13155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JH254_13160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JH254_13165	COG4771	TonB-dependent receptor
JH254_13205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JH254_13210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JH254_13215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JH254_13220	COG0861	Integral membrane protein TerC family
JH254_13235	COG1022	Amp-dependent synthetase and ligase
JH254_13240	COG0295	cytidine deaminase activity
JH254_13245	COG1346	cytolysis
JH254_13250	COG1380	Effector of murein hydrolase LrgA
JH254_13255	COG3345	alpha-galactosidase
JH254_13265	COG2925	Exonuclease
JH254_13270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JH254_13275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JH254_13275	COG0392	lysyltransferase activity
JH254_13290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JH254_13295	COG0436	Aminotransferase
JH254_13300	COG0583	DNA-binding transcription factor activity
JH254_13305	COG2160	L-arabinose isomerase activity
JH254_13315	COG1069	ribulokinase activity
JH254_13320	COG1879	ABC-type sugar transport system periplasmic component
JH254_13325	COG1129	ABC transporter
JH254_13330	COG1172	Belongs to the binding-protein-dependent transport system permease family
JH254_13340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JH254_13345	COG0254	rRNA binding
JH254_13360	COG1451	nucleotide metabolic process
JH254_13375	COG3069	C4-dicarboxylate transmembrane transporter activity
JH254_13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH254_13385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JH254_13390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JH254_13410	COG2009	succinate dehydrogenase
JH254_13415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JH254_13430	COG0567	Dehydrogenase, E1 component
JH254_13435	COG0508	dehydrogenase complex catalyzes the overall conversion of
JH254_13440	COG0045	succinate-CoA ligase (ADP-forming) activity
JH254_13445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JH254_13460	COG0316	Belongs to the HesB IscA family
JH254_13470	COG0038	chloride channel
JH254_13475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JH254_13490	COG0671	phosphoesterase, PA-phosphatase related
JH254_13500	COG0583	DNA-binding transcription factor activity
JH254_13505	COG2076	Multidrug Resistance protein
JH254_13515	COG0346	lactoylglutathione lyase activity
JH254_13520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JH254_13525	COG1643	Atp-dependent helicase
JH254_13535	COG1489	DNA binding
JH254_13540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JH254_13545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JH254_13555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JH254_13560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JH254_13565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JH254_13575	COG0842	Transport permease protein
JH254_13580	COG1131	(ABC) transporter
JH254_13595	COG0163	prenyltransferase activity
JH254_13600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JH254_13605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JH254_13620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JH254_13635	COG1136	(ABC) transporter
JH254_13655	COG0840	transmembrane signaling receptor activity
JH254_13675	COG0529	Catalyzes the synthesis of activated sulfate
JH254_13680	COG0471	metal ion transport
JH254_13680	COG3273	potassium ion transport
JH254_13685	COG2895	sulfate adenylyltransferase (ATP) activity
JH254_13690	COG0175	sulfate reduction
JH254_13695	COG1648	precorrin-2 dehydrogenase activity
JH254_13695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JH254_13700	COG0330	HflC and HflK could
JH254_13705	COG1585	Membrane protein implicated in regulation of membrane protease activity
JH254_13715	COG0673	inositol 2-dehydrogenase activity
JH254_13725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JH254_13730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JH254_13735	COG3036	rescue of stalled ribosome
JH254_13750	COG0138	bifunctional purine biosynthesis protein purh
JH254_13790	COG0732	type I restriction modification DNA specificity domain
JH254_13795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JH254_13805	COG0477	Major facilitator Superfamily
JH254_13810	COG0583	DNA-binding transcription factor activity
JH254_13815	COG3227	Zinc metalloprotease (Elastase)
JH254_13820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JH254_13825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JH254_13835	COG2731	YhcH YjgK YiaL family protein
JH254_13845	COG0668	transmembrane transport
JH254_13855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JH254_13865	COG0789	Transcriptional regulator
JH254_13910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JH254_13920	COG0488	(ABC) transporter
JH254_13925	COG0516	GMP reductase activity
JH254_13925	COG0517	IMP dehydrogenase activity
JH254_13935	COG0784	Response regulator, receiver
JH254_13935	COG0835	chemotaxis
JH254_13940	COG2755	lipolytic protein G-D-S-L family
JH254_13945	COG4181	ATPase activity
JH254_13950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JH254_13955	COG1090	epimerase
JH254_13960	COG2200	EAL domain
JH254_13965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JH254_13970	COG2234	aminopeptidase activity
JH254_13970	COG4935	Belongs to the peptidase S8 family
JH254_13975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JH254_13980	COG3171	Protein conserved in bacteria
JH254_13985	COG2066	Belongs to the glutaminase family
JH254_14000	COG1132	(ABC) transporter
JH254_14025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
JH254_14030	COG3300	MHYT domain
JH254_14030	COG5001	Diguanylate cyclase
JH254_14050	COG4628	conserved protein (DUF2132)
JH254_14055	COG0688	phosphatidylethanolamine metabolic process
JH254_14060	COG1162	GTPase activity
JH254_14065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JH254_14105	COG1278	Cold shock
JH254_14115	COG0840	transmembrane signaling receptor activity
JH254_14120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JH254_14125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JH254_14190	COG1609	Transcriptional regulator
JH254_14195	COG3250	beta-galactosidase activity
JH254_14200	COG2731	YhcH YjgK YiaL family protein
JH254_14205	COG0531	amino acid
JH254_14210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JH254_14215	COG0531	amino acid
JH254_14220	COG0385	Bile acid
JH254_14225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JH254_14250	COG0583	DNA-binding transcription factor activity
JH254_14255	COG1079	Belongs to the binding-protein-dependent transport system permease family
JH254_14260	COG4603	Belongs to the binding-protein-dependent transport system permease family
JH254_14265	COG3845	ABC transporter
JH254_14270	COG1744	ABC transporter substrate-binding protein PnrA-like
JH254_14275	COG0210	DNA helicase
JH254_14305	COG0583	DNA-binding transcription factor activity
JH254_14340	COG0583	DNA-binding transcription factor activity
JH254_14355	COG1280	lysine exporter protein (LysE YggA)
JH254_14365	COG2962	Rard protein
JH254_14375	COG1012	belongs to the aldehyde dehydrogenase family
JH254_14380	COG1396	sequence-specific DNA binding
JH254_14385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JH254_14395	COG0519	Catalyzes the synthesis of GMP from XMP
JH254_14395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JH254_14405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH254_14425	COG1322	Protein conserved in bacteria
JH254_14430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JH254_14435	COG0569	domain protein
JH254_14440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JH254_14440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JH254_14445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JH254_14450	COG0242	peptide deformylase activity
JH254_14460	COG0758	DNA mediated transformation
JH254_14465	COG2922	Belongs to the Smg family
JH254_14470	COG0551	DNA topoisomerase type I activity
JH254_14475	COG0009	L-threonylcarbamoyladenylate synthase
JH254_14480	COG0408	coproporphyrinogen oxidase activity
JH254_14485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JH254_14490	COG2801	Transposase and inactivated derivatives
JH254_14530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JH254_14535	COG0745	RESPONSE REGULATOR receiver
JH254_14540	COG2205	protein histidine kinase activity
JH254_14550	COG0281	malic enzyme
JH254_14555	COG0702	epimerase
JH254_14560	COG0254	rRNA binding
JH254_14565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JH254_14570	COG1309	transcriptional regulator
JH254_14590	COG0129	dihydroxy-acid dehydratase activity
JH254_14600	COG3978	acetolactate synthase activity
JH254_14610	COG0606	chelatase, subunit chli
JH254_14615	COG0204	Acyl-transferase
JH254_14620	COG0204	Acyl-transferase
JH254_14625	COG1683	Conserved Protein
JH254_14635	COG1335	isochorismatase
JH254_14645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JH254_14650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JH254_14660	COG3084	Protein conserved in bacteria
JH254_14665	COG2203	Gaf domain
JH254_14665	COG3706	GGDEF domain
JH254_14665	COG4251	negative regulation of phosphorylation
JH254_14665	COG5001	Diguanylate cyclase
JH254_14680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JH254_14685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JH254_14690	COG1561	YicC-like family, N-terminal region
JH254_14700	COG1519	Transferase
JH254_14705	COG0859	PFAM glycosyl transferase family 9
JH254_14710	COG0463	Glycosyl transferase, family 2
JH254_14715	COG0859	PFAM glycosyl transferase family 9
JH254_14720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JH254_14725	COG2990	Protein conserved in bacteria
JH254_14730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JH254_14740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JH254_14745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JH254_14750	COG2003	Belongs to the UPF0758 family
JH254_14755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JH254_14760	COG0756	dUTP diphosphatase activity
JH254_14765	COG1309	transcriptional regulator
JH254_14780	COG0668	transmembrane transport
JH254_14790	COG0166	Belongs to the GPI family
JH254_14795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JH254_14800	COG0583	DNA-binding transcription factor activity
JH254_14810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JH254_14810	COG1042	CoA-binding domain protein
JH254_14810	COG0045	succinate-CoA ligase (ADP-forming) activity
JH254_14825	COG1484	DNA-dependent DNA replication
JH254_14835	COG5642	Protein of unknown function (DUF2384)
JH254_14840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JH254_14875	COG2197	response regulator
JH254_14880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JH254_14885	COG3047	cAMP biosynthetic process
JH254_14915	COG3135	benzoate transporter
JH254_14920	COG1396	sequence-specific DNA binding
JH254_14950	COG2926	Belongs to the UPF0265 family
JH254_14960	COG3028	Belongs to the UPF0307 family
JH254_14965	COG0312	modulator of DNA gyrase
JH254_14970	COG3071	HemY protein
JH254_14975	COG2959	enzyme of heme biosynthesis
JH254_14985	COG0181	hydroxymethylbilane synthase activity
JH254_14990	COG3072	Adenylate cyclase
JH254_14995	COG0400	carboxylic ester hydrolase activity
JH254_15000	COG1965	Belongs to the frataxin family
JH254_15010	COG0019	diaminopimelate decarboxylase activity
JH254_15015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JH254_15030	COG1011	Hydrolase
JH254_15040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JH254_15045	COG0561	phosphatase activity
JH254_15055	COG1988	membrane-bound metal-dependent
JH254_15060	COG1058	Belongs to the CinA family
JH254_15060	COG1546	Belongs to the CinA family
JH254_15065	COG1418	mRNA catabolic process
JH254_15070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JH254_15080	COG1522	sequence-specific DNA binding
JH254_15100	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JH254_15110	COG2252	PERMEase
JH254_15115	COG2376	Dihydroxyacetone kinase
JH254_15120	COG1461	Dihydroxyacetone kinase
JH254_15135	COG0583	DNA-binding transcription factor activity
JH254_15140	COG2957	Belongs to the agmatine deiminase family
JH254_15160	COG2957	Belongs to the agmatine deiminase family
JH254_15170	COG0628	permease
JH254_15175	COG0494	nUDIX hydrolase
JH254_15195	COG0753	catalase activity
JH254_15200	COG0456	acetyltransferase
JH254_15230	COG3842	ATPase activity
JH254_15240	COG1175	transmembrane transport
JH254_15265	COG0583	DNA-binding transcription factor activity
JH254_15275	COG1741	Belongs to the pirin family
JH254_15280	COG2259	Doxx family
JH254_15285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JH254_15290	COG1074	ATP-dependent DNA helicase activity
JH254_15295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JH254_15310	COG0346	lactoylglutathione lyase activity
JH254_15320	COG0004	ammonium transporteR
JH254_15325	COG0347	Belongs to the P(II) protein family
JH254_15330	COG3706	GGDEF domain
JH254_15360	COG1278	Cold shock
JH254_15425	COG1397	ADP-ribosylglycohydrolase
JH254_15430	COG1397	ADP-ribosylglycohydrolase
JH254_15460	COG1484	DNA-dependent DNA replication
JH254_15470	COG0203	ribosomal protein L17
JH254_15475	COG0202	RNA polymerase activity
JH254_15480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JH254_15485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JH254_15490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JH254_15495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JH254_15500	COG0201	protein transport
JH254_15505	COG0200	Binds to the 23S rRNA
JH254_15510	COG1841	ribosomal large subunit assembly
JH254_15515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JH254_15520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JH254_15525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JH254_15530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JH254_15535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JH254_15540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JH254_15545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JH254_15550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JH254_15555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JH254_15560	COG0255	Belongs to the universal ribosomal protein uL29 family
JH254_15565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JH254_15570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JH254_15575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JH254_15580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JH254_15585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JH254_15590	COG0089	rRNA binding
JH254_15595	COG0088	Forms part of the polypeptide exit tunnel
JH254_15600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JH254_15605	COG0051	transcription antitermination factor activity, RNA binding
JH254_15615	COG2205	protein histidine kinase activity
JH254_15625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JH254_15630	COG2183	response to ionizing radiation
JH254_15645	COG0596	Alpha beta hydrolase
JH254_15650	COG1040	competence protein
JH254_15655	COG0316	Belongs to the HesB IscA family
JH254_15655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JH254_15660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JH254_15665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JH254_15670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JH254_15675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JH254_15680	COG4942	peptidase
JH254_15690	COG1609	Transcriptional regulator
JH254_15705	COG0800	Aldolase
JH254_15710	COG0129	dihydroxy-acid dehydratase activity
JH254_15715	COG3265	gluconokinase activity
JH254_15720	COG2610	gluconate transmembrane transporter activity
JH254_15725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH254_15730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JH254_15740	COG0456	acetyltransferase
JH254_15750	COG1490	D-aminoacyl-tRNA deacylase activity
JH254_15755	COG1295	ribonuclease BN
JH254_15760	COG1217	gtp-binding protein TYPA
JH254_15765	COG0174	glutamine synthetase
JH254_15775	COG3852	Histidine kinase
JH254_15785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JH254_15790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JH254_15800	COG3078	GTPase activator activity
JH254_15870	COG1073	alpha beta
JH254_15875	COG1073	alpha beta
JH254_15895	COG1172	Belongs to the binding-protein-dependent transport system permease family
JH254_15900	COG1172	Belongs to the binding-protein-dependent transport system permease family
JH254_15905	COG1129	ABC transporter
JH254_15910	COG1879	ABC-type sugar transport system periplasmic component
JH254_15930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JH254_15935	COG0243	molybdopterin cofactor binding
JH254_15945	COG0583	DNA-binding transcription factor activity
JH254_15950	COG2723	6-phospho-beta-galactosidase activity
JH254_15960	COG0583	DNA-binding transcription factor activity
JH254_15980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JH254_15985	COG0673	inositol 2-dehydrogenase activity
JH254_15990	COG0583	DNA-binding transcription factor activity
JH254_16000	COG1560	Kdo2-lipid A biosynthetic process
JH254_16005	COG1560	Kdo2-lipid A biosynthetic process
JH254_16020	COG0417	DNA replication proofreading
JH254_16050	COG0534	Mate efflux family protein
JH254_16060	COG0307	riboflavin synthase, alpha
JH254_16075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH254_16080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JH254_16085	COG0697	spore germination
JH254_16090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JH254_16120	COG0675	Transposase, IS605 OrfB family
JH254_16125	COG0675	Transposase, IS605 OrfB family
JH254_16140	COG3706	GGDEF domain
JH254_16140	COG4251	negative regulation of phosphorylation
JH254_16140	COG5001	Diguanylate cyclase
JH254_16140	COG2203	Gaf domain
JH254_16160	COG0814	amino acid
JH254_16165	COG0814	amino acid
JH254_16170	COG3033	Beta-eliminating lyase
JH254_16180	COG0348	domain, Protein
JH254_16190	COG0446	pyridine nucleotide-disulphide oxidoreductase
JH254_16195	COG0426	domain, Protein
JH254_16195	COG1773	rubredoxin
JH254_16200	COG3604	Transcriptional regulator
JH254_16205	COG1609	Transcriptional regulator
JH254_16245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JH254_16260	COG2960	long-chain fatty acid transporting porin activity
JH254_16270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JH254_16285	COG3118	belongs to the thioredoxin family
JH254_16290	COG0513	Belongs to the DEAD box helicase family
JH254_16295	COG0248	Ppx GppA phosphatase
JH254_16310	COG0742	ribosomal rna small subunit methyltransferase
JH254_16330	COG0084	hydrolase, TatD family'
JH254_16335	COG0805	protein transport
JH254_16340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JH254_16345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JH254_16350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JH254_16355	COG3165	ubiquinone biosynthetic process from chorismate
JH254_16365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JH254_16370	COG0402	S-adenosylhomocysteine deaminase activity
JH254_16425	COG1280	lysine exporter protein (LysE YggA)
JH254_16430	COG2223	nitrite transmembrane transporter activity
JH254_16435	COG2081	HI0933 family
JH254_16440	COG1528	Iron-storage protein
JH254_16445	COG3706	GGDEF domain
JH254_16450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JH254_16455	COG0589	response to stress
JH254_16495	COG3642	lipopolysaccharide core region biosynthetic process
JH254_16500	COG0859	PFAM glycosyl transferase family 9
JH254_16510	COG1758	RNA polymerase activity
JH254_16515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JH254_16520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JH254_16530	COG2267	carboxylic ester hydrolase activity
JH254_16535	COG0561	phosphatase activity
JH254_16565	COG1309	transcriptional regulator
JH254_16570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_16575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH254_16580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_16580	COG4191	Histidine kinase
JH254_16585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH254_16595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH254_16620	COG2205	protein histidine kinase activity
JH254_16625	COG0745	RESPONSE REGULATOR receiver
JH254_16630	COG2814	Major facilitator Superfamily
JH254_16645	COG3977	Valine--pyruvate aminotransferase
JH254_16650	COG0071	Belongs to the small heat shock protein (HSP20) family
JH254_16655	COG0071	Belongs to the small heat shock protein (HSP20) family
JH254_16660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JH254_16665	COG2207	Transcriptional regulator
JH254_16685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JH254_16690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JH254_16695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JH254_16700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JH254_16725	COG2716	regulation of RNA biosynthetic process
JH254_16730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JH254_16740	COG2239	Acts as a magnesium transporter
JH254_16755	COG3951	Flagellar rod assembly protein muramidase FlgJ
JH254_16755	COG1705	Flagellar rod assembly protein muramidase FlgJ
JH254_16760	COG1706	bacterial-type flagellum-dependent cell motility
JH254_16765	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JH254_16780	COG1749	Flagellar hook protein flgE
JH254_16795	COG1815	bacterial-type flagellum-dependent cell motility
JH254_16800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JH254_16805	COG0784	Response regulator, receiver
JH254_16805	COG0835	chemotaxis
JH254_16810	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
JH254_16825	COG0622	Phosphoesterase
JH254_16830	COG4166	transmembrane transport
JH254_16845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JH254_16855	COG0697	spore germination
JH254_16860	COG4166	transmembrane transport
JH254_16885	COG1278	Cold shock
JH254_16900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JH254_16925	COG3132	Protein of unknown function, DUF480
JH254_16945	COG2841	Protein conserved in bacteria
JH254_16955	COG0534	Mate efflux family protein
JH254_16980	COG1454	alcohol dehydrogenase
JH254_16990	COG1309	transcriptional regulator
JH254_17005	COG0791	NLP P60 protein
JH254_17010	COG0583	DNA-binding transcription factor activity
JH254_17030	COG0500	methyltransferase
JH254_17035	COG4106	trans-aconitate 2-methyltransferase activity
JH254_17040	COG1801	Protein of unknown function DUF72
JH254_17045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JH254_17050	COG0217	transcriptional regulatory protein
JH254_17055	COG2194	sulfuric ester hydrolase activity
JH254_17060	COG1846	Transcriptional regulator
JH254_17060	COG1940	carbohydrate kinase activity
JH254_17065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JH254_17070	COG0363	glucosamine-6-phosphate deaminase activity
JH254_17075	COG1263	PTS System
JH254_17075	COG2190	(PTS) system
JH254_17075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JH254_17085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JH254_17090	COG0735	belongs to the Fur family
JH254_17100	COG0716	FMN binding
JH254_17115	COG0596	Alpha beta hydrolase
JH254_17120	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JH254_17125	COG0033	Phosphoglucomutase
JH254_17135	COG1846	Transcriptional regulator
JH254_17140	COG2951	lytic endotransglycosylase activity
JH254_17145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JH254_17150	COG4136	ATPase activity
JH254_17160	COG4134	Bacterial extracellular solute-binding protein
JH254_17165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH254_17170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JH254_17180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JH254_17205	COG0300	oxidoreductase activity
JH254_17215	COG0840	transmembrane signaling receptor activity
JH254_17220	COG0697	spore germination
JH254_17225	COG2610	gluconate transmembrane transporter activity
JH254_17230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JH254_17235	COG3622	Belongs to the hyi family
JH254_17240	COG0235	Class ii aldolase
JH254_17250	COG2084	Dehydrogenase
JH254_17255	COG1349	DNA-binding transcription factor activity
JH254_17265	COG2133	pyrroloquinoline quinone binding
JH254_17300	COG0077	Prephenate dehydratase
JH254_17300	COG1605	Chorismate mutase
JH254_17325	COG3272	Protein of unknown function (DUF1722)
JH254_17330	COG0789	Transcriptional regulator
JH254_17335	COG0415	Belongs to the DNA photolyase family
JH254_17345	COG4221	oxidoreductase activity
JH254_17360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JH254_17385	COG0783	Belongs to the Dps family
JH254_17390	COG1151	hydroxylamine reductase activity
JH254_17400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JH254_17420	COG1447	Phosphotransferase system cellobiose-specific component IIA
JH254_17425	COG2723	6-phospho-beta-galactosidase activity
JH254_17440	COG0659	secondary active sulfate transmembrane transporter activity
JH254_17465	COG5377	YqaJ viral recombinase family
JH254_17485	COG4983	Phage plasmid primase, P4 family domain protein
JH254_17495	COG2003	Belongs to the UPF0758 family
JH254_17500	COG0443	Heat shock 70 kDa protein
JH254_17510	COG2916	Histone family protein nucleoid-structuring protein H-NS
JH254_17525	COG0582	viral genome integration into host DNA
JH254_17530	COG0784	Response regulator, receiver
JH254_17530	COG2205	protein histidine kinase activity
JH254_17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_17555	COG2205	protein histidine kinase activity
JH254_17560	COG3384	dioxygenase
JH254_17570	COG1283	sodium-dependent phosphate transmembrane transporter activity
JH254_17580	COG0531	amino acid
JH254_17585	COG0531	amino acid
JH254_17600	COG1012	belongs to the aldehyde dehydrogenase family
JH254_17605	COG1917	Cupin 2, conserved barrel domain protein
JH254_17605	COG1396	sequence-specific DNA binding
JH254_17610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH254_17635	COG5433	transposase activity
JH254_17655	COG2203	Gaf domain
JH254_17655	COG2199	diguanylate cyclase activity
JH254_17690	COG2119	membrane
JH254_17695	COG0023	Translation Initiation Factor
JH254_17705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JH254_17730	COG4139	cobalamin transport
JH254_17735	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JH254_17740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JH254_17745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JH254_17750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JH254_17755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JH254_17760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JH254_17770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JH254_17775	COG0505	Belongs to the CarA family
JH254_17780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JH254_17785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JH254_17790	COG3706	GGDEF domain
JH254_17820	COG0513	Belongs to the DEAD box helicase family
JH254_17830	COG4104	PAAR repeat-containing protein
JH254_17850	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JH254_17855	COG0437	4 iron, 4 sulfur cluster binding
JH254_17860	COG3301	Polysulphide reductase, NrfD
JH254_17865	COG1138	Cytochrome C-type biogenesis protein
JH254_17870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH254_17875	COG3088	subunit of a heme lyase
JH254_17875	COG4235	cytochrome complex assembly
JH254_17890	COG3046	protein related to deoxyribodipyrimidine photolyase
JH254_17895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH254_17900	COG0617	tRNA 3'-terminal CCA addition
JH254_17900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JH254_17900	COG0517	IMP dehydrogenase activity
JH254_17910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JH254_17915	COG0583	DNA-binding transcription factor activity
JH254_17925	COG4774	siderophore transport
JH254_17935	COG2200	EAL domain
JH254_17935	COG2771	luxR family
JH254_17940	COG4977	sequence-specific DNA binding
JH254_17940	COG1917	Cupin 2, conserved barrel domain protein
JH254_17945	COG0583	DNA-binding transcription factor activity
JH254_17950	COG2910	NAD(P)H-binding
JH254_17960	COG0626	cystathionine gamma-synthase activity
JH254_17965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JH254_17985	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JH254_17990	COG1349	DNA-binding transcription factor activity
JH254_18015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JH254_18035	COG1435	thymidine kinase activity
JH254_18040	COG1757	Na H antiporter
JH254_18065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JH254_18070	COG0358	DNA primase activity
JH254_18075	COG1610	YqeY-like protein
JH254_18080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JH254_18085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JH254_18095	COG1388	LysM domain
JH254_18095	COG4942	peptidase
JH254_18100	COG1238	metal cluster binding
JH254_18105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JH254_18110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JH254_18115	COG0585	pseudouridine synthase activity
JH254_18125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JH254_18130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JH254_18135	COG0148	phosphopyruvate hydratase activity
JH254_18140	COG0504	CTP synthase activity
JH254_18145	COG3956	TIGRFAM MazG family protein
JH254_18150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JH254_18155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JH254_18165	COG4807	Protein conserved in bacteria
JH254_18170	COG3023	N-Acetylmuramoyl-L-alanine amidase
JH254_18175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JH254_18180	COG1381	Involved in DNA repair and RecF pathway recombination
JH254_18190	COG0571	ribonuclease III activity
JH254_18195	COG0681	Belongs to the peptidase S26 family
JH254_18200	COG0481	GTPase activity
JH254_18215	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JH254_18220	COG1595	DNA-templated transcription, initiation
JH254_18225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JH254_18235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JH254_18285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JH254_18355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JH254_18365	COG0121	glutamine amidotransferase
JH254_18370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JH254_18375	COG1960	acyl-CoA dehydrogenase activity
JH254_18380	COG3437	response regulator, receiver
JH254_18380	COG0784	Response regulator, receiver
JH254_18390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JH254_18395	COG0328	RNA-DNA hybrid ribonuclease activity
JH254_18400	COG2226	methyltransferase
JH254_18405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JH254_18410	COG0741	lytic transglycosylase activity
JH254_18410	COG1388	LysM domain
JH254_18425	COG1607	acyl-coa hydrolase
JH254_18440	COG0741	lytic transglycosylase activity
JH254_18450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JH254_18470	COG2911	Protein conserved in bacteria
JH254_18475	COG0729	surface antigen
JH254_18485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JH254_18490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_18520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JH254_18535	COG0438	transferase activity, transferring glycosyl groups
JH254_18555	COG2244	polysaccharide biosynthetic process
JH254_18580	COG1737	Transcriptional regulator
JH254_18585	COG0469	pyruvate kinase activity
JH254_18595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH254_18600	COG1960	acyl-CoA dehydrogenase activity
JH254_18610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JH254_18625	COG1074	ATP-dependent DNA helicase activity
JH254_18640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JH254_18655	COG0590	tRNA wobble adenosine to inosine editing
JH254_18660	COG0573	inorganic phosphate transmembrane transporter activity
JH254_18665	COG0581	inorganic phosphate transmembrane transporter activity
JH254_18670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JH254_18675	COG0704	Plays a role in the regulation of phosphate uptake
JH254_18680	COG1253	flavin adenine dinucleotide binding
JH254_18695	COG0531	amino acid
JH254_18705	COG1126	abc transporter atp-binding protein
JH254_18710	COG0765	amino acid transport
JH254_18715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_18725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JH254_18745	COG1785	Belongs to the alkaline phosphatase family
JH254_18750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JH254_18760	COG0123	including yeast histone deacetylase and acetoin utilization protein
JH254_18770	COG1028	Short-chain dehydrogenase reductase Sdr
JH254_18775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JH254_18780	COG1535	isochorismatase
JH254_18780	COG3433	isochorismatase activity
JH254_18785	COG1021	2,3-dihydroxybenzoate-AMP ligase
JH254_18805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JH254_18810	COG5001	Diguanylate cyclase
JH254_18810	COG3300	MHYT domain
JH254_18825	COG0840	transmembrane signaling receptor activity
JH254_18830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH254_18835	COG3788	relative of glutathione S-transferase, MAPEG superfamily
JH254_18840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JH254_18845	COG0563	adenylate kinase activity
JH254_18850	COG0326	Molecular chaperone. Has ATPase activity
JH254_18855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JH254_18875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JH254_18885	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JH254_18890	COG2261	transglycosylase associated protein
JH254_18895	COG1309	transcriptional regulator
JH254_18900	COG0604	alcohol dehydrogenase
JH254_18930	COG0322	excinuclease ABC activity
JH254_18935	COG2197	response regulator
JH254_18940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JH254_18945	COG2835	tetraacyldisaccharide 4'-kinase activity
JH254_18950	COG1663	tetraacyldisaccharide 4'-kinase activity
JH254_18955	COG1132	(ABC) transporter
JH254_18960	COG0658	competence protein
JH254_18960	COG2333	competence protein COMEC
JH254_18975	COG0433	COG0433 Predicted ATPase
JH254_18980	COG1448	Aminotransferase
JH254_18995	COG1199	ATP-dependent helicase activity
JH254_19020	COG0495	leucyl-tRNA aminoacylation
JH254_19025	COG2888	peptidyl-tyrosine sulfation
JH254_19030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JH254_19035	COG4535	Mg2 and Co2 transporter CorC
JH254_19040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JH254_19045	COG1702	phosphate starvation-inducible protein PhoH
JH254_19050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JH254_19055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH254_19060	COG1335	isochorismatase
JH254_19075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH254_19090	COG3706	GGDEF domain
JH254_19100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JH254_19115	COG1464	Belongs to the NlpA lipoprotein family
JH254_19120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JH254_19125	COG2011	ABC-type metal ion transport system permease component
JH254_19130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JH254_19140	COG0516	GMP reductase activity
JH254_19145	COG0189	ligase activity
JH254_19145	COG4067	protein conserved in archaea
JH254_19155	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JH254_19170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JH254_19225	COG2003	Belongs to the UPF0758 family
JH254_19295	COG0569	domain protein
JH254_19295	COG2985	domain, Protein
JH254_19300	COG1272	protein, Hemolysin III
JH254_19305	COG0076	glutamate decarboxylase activity
JH254_19310	COG2917	probably involved in intracellular septation
JH254_19315	COG2350	Protein conserved in bacteria
JH254_19325	COG1555	photosystem II stabilization
JH254_19330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JH254_19335	COG3104	oligopeptide transport
JH254_19340	COG0745	RESPONSE REGULATOR receiver
JH254_19370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_19385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JH254_19390	COG1280	lysine exporter protein (LysE YggA)
JH254_19400	COG0751	glycine-tRNA ligase activity
JH254_19405	COG0752	glycyl-tRNA synthetase alpha subunit
JH254_19410	COG2818	Glycosylase
JH254_19415	COG1335	isochorismatase
JH254_19425	COG2885	chlorophyll binding
JH254_19445	COG0251	oxidation-reduction process
JH254_19450	COG0425	Belongs to the sulfur carrier protein TusA family
JH254_19475	COG0183	Belongs to the thiolase family
JH254_19480	COG1024	Enoyl-CoA hydratase
JH254_19480	COG1250	3-hydroxyacyl-CoA dehydrogenase
JH254_19485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JH254_19490	COG0006	proline dipeptidase activity
JH254_19495	COG1739	Uncharacterized protein family UPF0029
JH254_19500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JH254_19505	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
JH254_19525	COG1376	ErfK ybiS ycfS ynhG family protein
JH254_19525	COG1388	LysM domain
JH254_19540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JH254_19545	COG0791	NLP P60 protein
JH254_19555	COG3118	belongs to the thioredoxin family
JH254_19565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JH254_19570	COG0788	formyltetrahydrofolate deformylase activity
JH254_19595	COG0739	heme binding
JH254_19595	COG0741	lytic transglycosylase activity
JH254_19595	COG1196	nuclear chromosome segregation
JH254_19605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JH254_19610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JH254_19615	COG0673	inositol 2-dehydrogenase activity
JH254_19635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JH254_19640	COG1011	Hydrolase
JH254_19645	COG1473	amidohydrolase
JH254_19650	COG0205	6-phosphofructokinase activity
JH254_19660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JH254_19665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JH254_19675	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JH254_19680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JH254_19705	COG0588	phosphoglycerate mutase activity
JH254_19760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_19795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH254_19800	COG3041	Addiction module toxin RelE StbE family
JH254_19805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JH254_19820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JH254_19825	COG1115	amino acid carrier protein
JH254_19845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JH254_19855	COG0189	ligase activity
JH254_19860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JH254_19870	COG3091	SprT-like family
JH254_19880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JH254_19895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JH254_19900	COG0765	amino acid transport
JH254_19905	COG1126	abc transporter atp-binding protein
JH254_19910	COG0493	'glutamate synthase
JH254_19915	COG0070	glutamate synthase
JH254_19915	COG0069	glutamate synthase activity
JH254_19915	COG0067	glutamate synthase
JH254_19920	COG1242	4 iron, 4 sulfur cluster binding
JH254_19955	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
JH254_19970	COG0577	efflux transmembrane transporter activity
JH254_19970	COG1136	(ABC) transporter
JH254_19975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH254_19980	COG0745	RESPONSE REGULATOR receiver
JH254_19985	COG2205	protein histidine kinase activity
JH254_20050	COG0012	GTP binding
JH254_20055	COG0193	aminoacyl-tRNA hydrolase activity
JH254_20060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JH254_20070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JH254_20075	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JH254_20080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JH254_20085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JH254_20090	COG2890	protein-(glutamine-N5) methyltransferase activity
JH254_20100	COG2912	Transglutaminase-like superfamily
JH254_20105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JH254_20110	COG1301	dicarboxylic acid transport
JH254_20120	COG5433	transposase activity
JH254_20135	COG1917	Cupin 2, conserved barrel domain protein
JH254_20135	COG2207	Transcriptional regulator
JH254_20145	COG0513	Belongs to the DEAD box helicase family
JH254_20150	COG2203	Gaf domain
JH254_20150	COG2199	diguanylate cyclase activity
JH254_20190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH254_20215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JH254_20220	COG1596	polysaccharide export
JH254_20225	COG0187	DNA topoisomerase II activity
JH254_20235	COG0592	DNA-directed DNA polymerase activity
JH254_20240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JH254_20285	COG2003	Belongs to the UPF0758 family
JH254_20355	COG2850	peptidyl-arginine hydroxylation
JH254_20410	COG5642	Protein of unknown function (DUF2384)
JH254_20480	COG1334	flagellar protein FlaG
JH254_20520	COG5499	transcription regulator containing HTH domain
JH254_20590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JH254_20680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JH254_20720	COG0419	ATPase involved in DNA repair
JH254_20830	COG0776	regulation of translation
JH254_20850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JH254_20940	COG0358	DNA primase activity
JH254_20960	COG1923	regulation of RNA biosynthetic process
JH254_20990	COG5301	cellulose 1,4-beta-cellobiosidase activity
JH254_21120	COG1136	(ABC) transporter
JH254_21140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JH254_21175	COG4974	Belongs to the 'phage' integrase family