locus-tag class description MC60_000005 ENOG4105DN3 alpha-2-macroglobulin domain protein MC60_000010 ENOG4108JQB penicillin-binding protein 1C MC60_000020 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) MC60_000030 ENOG4105EN6 Membrane MC60_000035 ENOG4105I03 Flagellin MC60_000040 ENOG4105I03 Flagellin MC60_000055 ENOG4105MQ3 flagellar protein FliS MC60_000080 ENOG4105D2T synthase MC60_000090 ENOG4105F0R Cytidylyltransferase MC60_000105 ENOG4105CHR reductase MC60_000110 ENOG4105CEY Amp-dependent synthetase and ligase MC60_000125 ENOG4105CND Glycosyl transferase, family 2 MC60_000130 ENOG4107R6R udp-galactopyranose mutase MC60_000140 ENOG4105K64 Glycosyl transferase, family 2 MC60_000160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MC60_000165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MC60_000170 ENOG4105C5E polysaccharide biosynthesis protein MC60_000175 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) MC60_000185 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) MC60_000205 ENOG4108UYE Lactoylglutathione lyase MC60_000210 ENOG4105CSM endonuclease III MC60_000215 ENOG4105DZB Electron transport complex MC60_000220 ENOG4108UQQ Electron transport complex MC60_000225 ENOG4105D6A Electron transport complex MC60_000235 ENOG4108R3D Electron transport complex MC60_000240 ENOG4105DGN Electron transport complex MC60_000245 ENOG4108PCN EamA-like transporter family MC60_000255 ENOG4107SDU Methyl-accepting chemotaxis MC60_000265 ENOG4105RKW reductase (By MC60_000270 ENOG4105CSX c4-dicarboxylate anaerobic carrier MC60_000275 ENOG4105CHM Aminotransferase MC60_000285 ENOG41090BQ Glutaredoxin MC60_000290 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase MC60_000295 ENOG4105CFI type iii restriction protein res subunit MC60_000300 ENOG4105EFX secretion protein, HlyD family MC60_000305 ENOG4105KK7 inner membrane protein YiaW MC60_000310 ENOG4105EGS Mechanosensitive ion channel MC60_000320 ENOG4108NEV two component transcriptional regulator, LytTR family MC60_000325 ENOG4108HRK Histidine kinase MC60_000330 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase MC60_000335 ENOG4108EKI Dehydrogenase MC60_000340 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein MC60_000345 ENOG4107QSI ABC, transporter MC60_000350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC60_000355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC60_000360 ENOG4105C3U ABC transporter MC60_000365 ENOG4108JQ7 (ABC) transporter MC60_000370 ENOG4105DU1 integral membrane protein, terc MC60_000375 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MC60_000385 ENOG4107QJT sodium dicarboxylate symporter MC60_000405 ENOG4105CD3 dihydroorotase MC60_000415 ENOG4108NVR Methyl-accepting chemotaxis MC60_000420 ENOG4105K59 histidine triad (HIT) protein MC60_000455 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MC60_000460 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MC60_000475 ENOG4105CKW Inner membrane protein yedI MC60_000480 ENOG4105DPN Oligoendopeptidase f MC60_000485 ENOG4105DPN Oligoendopeptidase f MC60_000495 ENOG4105CEP NADH dehydrogenase MC60_000505 ENOG4105K8R UPF0145 protein MC60_000510 ENOG4107T7U Sulfatase MC60_000520 ENOG4105CFH Aspartokinase MC60_000525 ENOG4107QZM n-acetylglutamate synthase MC60_000530 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MC60_000555 ENOG4105CR8 Transcriptional regulator MC60_000560 ENOG4105DAA L-lactate MC60_000565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MC60_000570 ENOG4107QR9 Iron-sulfur cluster binding protein MC60_000575 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) MC60_000595 ENOG4105F2I Transposase MC60_000615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) MC60_000635 ENOG4105C2C drug resistance transporter, Bcr CflA MC60_000715 ENOG4105CHH sulfate transporter MC60_000735 ENOG4108WC9 type VI secretion system effector, hcp1 family MC60_000740 ENOG4105CS6 Rhs element vgr protein MC60_000750 ENOG4105CNA YD repeat protein MC60_000755 ENOG4108KQ5 Integrase catalytic subunit MC60_000810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MC60_000845 ENOG4105CS6 Rhs element vgr protein MC60_000855 ENOG4105E3S small subunit MC60_000860 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein MC60_000865 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit MC60_000870 ENOG4105DPX Hydrogenase, large subunit MC60_000875 ENOG4108USZ hydrogenase MC60_000880 ENOG4108WGS hydrogenase 2-specific chaperone MC60_000890 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC60_000895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC60_000905 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) MC60_000910 ENOG4107RSS Hydrogenase accessory protein HypB MC60_000915 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) MC60_000920 ENOG4105C45 hydrogenase expression formation protein (HypE) MC60_000925 ENOG4105CQS hydrogenase expression formation protein HypD MC60_000930 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF MC60_000940 ENOG4105DFH Transport of potassium into the cell (By similarity) MC60_000945 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) MC60_000950 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) MC60_000955 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) MC60_000960 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MC60_000965 ENOG4105WJG Glutathione MC60_000970 ENOG4107RE1 Inosine-guanosine kinase MC60_000975 ENOG4105C8Q Methyl-accepting chemotaxis MC60_000990 ENOG4105BZU Histidine kinase MC60_001005 ENOG4105F3T (LipO)protein MC60_001015 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MC60_001020 ENOG4105WQI isochorismatase MC60_001025 ENOG4105CEY Amp-dependent synthetase and ligase MC60_001030 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase MC60_001040 ENOG4105C0W non-ribosomal peptide synthetase MC60_001045 ENOG4105J76 Periplasmic binding protein MC60_001050 ENOG4108TSE Transferase MC60_001055 ENOG4105E0A ABC, transporter MC60_001060 ENOG4105TVJ transport system, permease MC60_001065 ENOG4105DQ5 transport system permease protein MC60_001070 ENOG4105D05 Receptor MC60_001085 ENOG4105QZU Inner membrane protein YfeZ MC60_001090 ENOG4107QUT magnesium and cobalt transport protein CorA MC60_001095 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase MC60_001100 ENOG4105BZJ Electron transfer flavoprotein MC60_001105 ENOG4105C10 Electron transfer flavoprotein MC60_001110 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) MC60_001115 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase MC60_001120 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) MC60_001125 ENOG4105EE5 Membrane protein terC MC60_001135 ENOG4105MH2 YfcL protein MC60_001140 ENOG4108IQE Amp-dependent synthetase and ligase MC60_001145 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) MC60_001150 ENOG41067MG lrgb family MC60_001155 ENOG4105VAW lrga family MC60_001160 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 MC60_001170 ENOG4105CJB Exodeoxyribonuclease I MC60_001205 ENOG4108RKS Short-chain dehydrogenase reductase Sdr MC60_001225 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) MC60_001230 ENOG4105F0Z galactose-1-phosphate uridylyltransferase MC60_001235 ENOG4105CMR udp-glucose 4-epimerase MC60_001240 ENOG41060NJ transcriptional regulator MC60_001245 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) MC60_001260 ENOG4105C8Q Methyl-accepting chemotaxis MC60_001270 ENOG4107FKK extracellular solute-binding protein family 1 MC60_001280 ENOG4105EG2 ABC transporter, permease MC60_001290 ENOG4105C4C beta-galactosidase MC60_001295 ENOG4105CI1 PTS System MC60_001305 ENOG4105CA9 Pyruvate kinase MC60_001325 ENOG4108F5E vimentin MC60_001330 ENOG4108YIV MC60_001370 ENOG4105FF5 Membrane MC60_001380 ENOG4105E89 ABC transporter MC60_001390 ENOG4105CHM Aminotransferase MC60_001395 ENOG4105ETT transcriptional Regulator, LysR family MC60_001400 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) MC60_001410 ENOG4105EF1 ribulokinase MC60_001415 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator MC60_001425 ENOG4105CNN ABC, transporter MC60_001440 ENOG4105NRA 50s ribosomal protein l31 type b MC60_001455 ENOG4108VKG metal-dependent hydrolase MC60_001470 ENOG4105CEE C4-dicarboxylate transporter MC60_001480 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) MC60_001485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MC60_001500 ENOG4105BZN citrate synthase MC60_001505 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit MC60_001510 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein MC60_001515 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) MC60_001520 ENOG4105E33 succinate dehydrogenase MC60_001525 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 MC60_001530 ENOG4105C7S Dehydrogenase MC60_001535 ENOG4105CMV Succinyl-CoA synthetase subunit beta MC60_001540 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha MC60_001560 ENOG4105C6N Formate acetyltransferase MC60_001565 ENOG4105TMB Formate nitrite transporter MC60_001570 ENOG4105DDY UPF0142 protein ycaO MC60_001580 ENOG4105KPY Small multidrug resistance protein MC60_001585 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MC60_001590 ENOG4105VEQ Cold shock protein MC60_001595 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) MC60_001600 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MC60_001605 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) MC60_001610 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate MC60_001615 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) MC60_001620 ENOG4107MBR 17 kDa surface antigen MC60_001625 ENOG4105BZU Histidine kinase MC60_001630 ENOG4105C3M thioredoxin reductase MC60_001635 ENOG4105DCF alanine dehydrogenase MC60_001640 ENOG4105EW9 transcriptional regulator AsnC family MC60_001645 ENOG4105CNU cell division protein FtsK MC60_001650 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) MC60_001655 ENOG4105D1H recombination factor protein RarA MC60_001665 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) MC60_001670 ENOG4105E96 Colicin v production protein MC60_001675 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase MC60_001680 ENOG4105CS2 ec 3.2.1.21 MC60_001685 ENOG4105C5Y PTS System MC60_001690 ENOG4105DDV Transcriptional regulator (LacI family MC60_001695 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase MC60_001700 ENOG4108JQ2 peptide transport system atp-binding protein MC60_001705 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein MC60_001710 ENOG4108EU3 peptide transport system, permease MC60_001715 ENOG4108I5W peptide transport system, permease protein MC60_001720 ENOG4108J59 Extracellular solute-binding protein, family 5 MC60_001725 ENOG4105E51 psp operon transcriptional activator MC60_001730 ENOG41087YS Phage shock protein A MC60_001735 ENOG4105YYT phage shock protein B MC60_001745 ENOG4105CM6 amino acid regulated cytosolic protein MC60_001750 ENOG4106K28 UPF0283 membrane protein MC60_001755 ENOG4105MIR Phenylalanine 4-monooxygenase MC60_001760 ENOG41090A4 Pterin carbinolamine dehydratase MC60_001770 ENOG4108WS1 MC60_001775 ENOG4105BZU Histidine kinase MC60_001780 ENOG41090EK ompa motb domain protein MC60_001785 ENOG4105D4P Coproporphyrinogen iii oxidase MC60_001790 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) MC60_001800 ENOG4105SG9 biopolymer transport protein, ExbD MC60_001815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) MC60_001825 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC60_001830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MC60_001840 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MC60_001860 ENOG41082F9 transcriptional regulator MC60_001870 ENOG4105FQ6 thiopurine methyltransferase MC60_001875 ENOG4107QXK peptidase MC60_001880 ENOG4108BY2 phosphohistidine phosphatase MC60_001890 ENOG4108IPJ Membrane MC60_001895 ENOG4107QSI ABC, transporter MC60_001900 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 MC60_001905 ENOG4108JA2 transcriptioN-repair coupling factor MC60_001915 ENOG4105D60 lipoprotein releasing system transmembrane protein MC60_001920 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) MC60_001925 ENOG4105D60 lipoprotein releasing system transmembrane protein MC60_001945 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation MC60_001950 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MC60_001955 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) MC60_001960 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) MC60_001965 ENOG4105K70 DNA-binding protein MC60_001970 ENOG4105EIN peptidylprolyl cis-trans isomerase MC60_001975 ENOG4105C5H ABC transporter MC60_001980 ENOG4107QN1 sodium solute MC60_001985 ENOG41062QD Membrane MC60_002000 ENOG41060WC Enoyl-CoA hydratase MC60_002005 ENOG4105BZG amino acid carrier protein MC60_002015 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) MC60_002020 ENOG4106HK8 GPR1 FUN34 yaaH family protein MC60_002035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase MC60_002045 ENOG4105E39 Enoyl-CoA hydratase MC60_002050 ENOG4107QX3 carboxylase MC60_002055 ENOG4105C1G acyl-Coa dehydrogenase MC60_002060 ENOG4105C26 Dehydrogenase MC60_002065 ENOG4105C1G acyl-Coa dehydrogenase MC60_002070 ENOG4105E39 Enoyl-CoA hydratase MC60_002075 ENOG4105E39 Enoyl-CoA hydratase MC60_002080 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MC60_002090 ENOG4105D5Q Arginine ornithine antiporter MC60_002095 ENOG4105HF0 Membrane MC60_002115 ENOG4105F2I Transposase MC60_002125 ENOG41062B0 ABC transporter, permease MC60_002130 ENOG4107R9N ABC transporter MC60_002135 ENOG4105C2J ABC transporter MC60_002140 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator MC60_002145 ENOG4105DND Transcriptional regulator MC60_002160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MC60_002165 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit MC60_002170 ENOG4105BZU Histidine kinase MC60_002175 ENOG4108KB2 LysR family Transcriptional regulator MC60_002180 ENOG4105CS2 ec 3.2.1.21 MC60_002185 ENOG4105CHR reductase MC60_002190 ENOG4105CBN LysR family transcriptional regulator MC60_002205 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) MC60_002215 ENOG4105DUM transcriptional regulator, lysR family MC60_002225 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase MC60_002230 ENOG4105D1S lipid A biosynthesis MC60_002240 ENOG4105EUB pirin domain protein MC60_002245 ENOG4105CQ2 DNA polymerase MC60_002275 ENOG4107QI1 Mate efflux family protein MC60_002280 ENOG4105W1I UPF0253 protein MC60_002285 ENOG4108R6K riboflavin synthase, subunit alpha MC60_002300 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 MC60_002305 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR MC60_002310 ENOG4108SXK Transporter Drug Metabolite Exporter family MC60_002315 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) MC60_002340 ENOG4105QNR S1 RNA binding domain protein MC60_002350 ENOG4105XW2 UPF0263 protein MC60_002360 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase MC60_002370 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) MC60_002375 ENOG4107QMS site-determining protein MC60_002380 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) MC60_002385 ENOG4105VNG YcgL domain-containing protein MC60_002390 ENOG4105CVE Lytic murein transglycosylase MC60_002395 ENOG4105EJQ L-serine dehydratase MC60_002405 ENOG4105EJQ L-serine dehydratase MC60_002410 ENOG4105NBK UPF0345 protein MC60_002415 ENOG4105CK2 sodium dicarboxylate symporter MC60_002425 ENOG4105CHU acetyl-coa acetyltransferase MC60_002430 ENOG4105D58 Diguanylate phosphodiesterase MC60_002435 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation MC60_002440 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation MC60_002480 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MC60_002485 ENOG4105CHU acetyl-coa acetyltransferase MC60_002490 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MC60_002500 ENOG4108VWS Yaeq family MC60_002520 ENOG4105EHG Permease protein MC60_002535 ENOG4107MBR 17 kDa surface antigen MC60_002540 ENOG4105CEY Amp-dependent synthetase and ligase MC60_002545 ENOG4105D29 Helix-turn-helix type 11 domain protein MC60_002555 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase MC60_002560 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) MC60_002565 ENOG4105BZU Histidine kinase MC60_002575 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase MC60_002580 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase MC60_002585 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) MC60_002595 ENOG4105CIH Imidazole acetol-phosphate transaminase MC60_002600 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) MC60_002605 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) MC60_002615 ENOG4105DVT helicase MC60_002620 ENOG41072GX Peptidase M22 Glycoprotease MC60_002630 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MC60_002635 ENOG4105CEY Amp-dependent synthetase and ligase MC60_002650 ENOG4105DXC membrane MC60_002660 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) MC60_002665 ENOG4105WD1 Membrane MC60_002670 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) MC60_002675 ENOG4107QMP dna polymerase iii subunits gamma and tau MC60_002680 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) MC60_002685 ENOG4105CR8 Transcriptional regulator MC60_002690 ENOG4105EUB pirin domain protein MC60_002695 ENOG4105DWD nucleoside recognition domain protein MC60_002700 ENOG4105WH1 Two component transcriptional regulator luxr family MC60_002710 ENOG4105CQ7 ATP-dependent helicase MC60_002720 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) MC60_002730 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase MC60_002735 ENOG4105C5X domain protein MC60_002740 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) MC60_002745 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) MC60_002750 ENOG4105FAT Acyl-transferase MC60_002770 ENOG4105DR4 Methyltransferase MC60_002775 ENOG4108N3W hemolysin secretion protein MC60_002780 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 MC60_002785 ENOG4108K3A Glutathione S-transferase MC60_002790 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MC60_002795 ENOG4105D1F ATP-binding protein MC60_002800 ENOG4105DBI uridine monophosphokinase MC60_002805 ENOG4105DHP deoxycytidine triphosphate deaminase MC60_002810 ENOG4105CJ3 phosphate transporter MC60_002815 ENOG4105C03 ribonuclease MC60_002820 ENOG4105EI2 Pseudouridine synthase MC60_002825 ENOG4108UHJ MAF-like protein MC60_002835 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein MC60_002840 ENOG4105VGS 50s ribosomal protein l32 MC60_002845 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) MC60_002850 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MC60_002855 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MC60_002860 ENOG4105CHR reductase MC60_002865 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MC60_002870 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MC60_002875 ENOG4105YAZ 4-amino-4-deoxychorismate lyase MC60_002880 ENOG4105HHA aminodeoxychorismate lyase MC60_002885 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) MC60_002890 ENOG4107QRG dna polymerase iii MC60_002895 ENOG4105F8V Hydrolase, tatD family MC60_002910 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B MC60_002915 ENOG4105DY2 Paraquat-inducible protein b MC60_002920 ENOG4105H2K paraquat-inducible protein a MC60_002930 ENOG4105X2V dna damage-inducible protein MC60_002940 ENOG4105DAN ATP-dependent protease MC60_002945 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) MC60_002950 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) MC60_002960 ENOG4105C5H ABC transporter MC60_002970 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) MC60_002975 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) MC60_002980 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) MC60_002985 ENOG4105C7I Dehydrogenase MC60_002995 ENOG4105CD8 aminopeptidase N MC60_003000 ENOG4105CN1 protease MC60_003005 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) MC60_003010 ENOG4108ZGC gaf domain protein MC60_003020 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i MC60_003035 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) MC60_003045 ENOG4105C59 p-type ATPase MC60_003060 ENOG4105DS0 Transcriptional regulator, Crp Fnr family MC60_003065 ENOG4105Q9Y Universal stress protein MC60_003070 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) MC60_003085 ENOG4108K3A Glutathione S-transferase MC60_003090 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) MC60_003095 ENOG4105C2J ABC transporter MC60_003100 ENOG4105CNN ABC, transporter MC60_003105 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator MC60_003110 ENOG4108RVA ribokinase MC60_003115 ENOG4105ETE Transcriptional regulator (LacI family MC60_003120 ENOG4105BZU Histidine kinase MC60_003130 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MC60_003145 ENOG4105BZU Histidine kinase MC60_003150 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) MC60_003155 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MC60_003160 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) MC60_003165 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) MC60_003170 ENOG41083UC 50s ribosomal protein L35 MC60_003175 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) MC60_003180 ENOG4105C22 threonyL-tRNA synthetase MC60_003200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC60_003205 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) MC60_003210 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MC60_003215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MC60_003220 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MC60_003225 ENOG4105XPH Ferredoxin MC60_003230 ENOG4105CA3 membrane-bound lytic murein transglycosylase MC60_003235 ENOG4105XZD Fe-S protein MC60_003240 ENOG4105DM4 PTS System MC60_003245 ENOG4105DE4 1-phosphofructokinase MC60_003250 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein MC60_003255 ENOG4107B7Y DNA-binding transcriptional regulator FruR MC60_003260 ENOG4105E0U tyrosine-specific transport protein MC60_003275 ENOG4105C1J atp-dependent rna helicase MC60_003285 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase MC60_003290 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) MC60_003295 ENOG4108DG9 Smr protein MutS2 MC60_003330 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA MC60_003370 ENOG4105D9N nucleoside MC60_003375 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) MC60_003415 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) MC60_003420 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) MC60_003425 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) MC60_003430 ENOG4106371 Methyltransferase MC60_003435 ENOG4107S90 membrAne MC60_003445 ENOG4105CTQ phosphohexokinase MC60_003450 ENOG4105CH2 amidohydrolase MC60_003460 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) MC60_003500 ENOG4105CPB ATP-dependent endonuclease of the OLD family MC60_003515 ENOG4105VP0 transcriptional regulator, lysR family MC60_003520 ENOG4105EJ9 Membrane MC60_003530 ENOG4106IUH DTW domain containing protein MC60_003535 ENOG4105CPF Cell wall formation (By similarity) MC60_003550 ENOG4105C1J atp-dependent rna helicase MC60_003565 ENOG4105KK4 UPF0060 membrane protein MC60_003590 ENOG41061CK Antibiotic biosynthesis monooxygenase MC60_003595 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) MC60_003615 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class MC60_003625 ENOG4105WQ3 Rna-binding protein MC60_003650 ENOG4105BZ1 (ABC) transporter MC60_003655 ENOG4105BZ1 (ABC) transporter MC60_003660 ENOG4105BZU Histidine kinase MC60_003665 ENOG4105K63 Thioredoxin MC60_003670 ENOG4105C8P )-transporter MC60_003680 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) MC60_003700 ENOG4105CRQ synthase (Component I) MC60_003710 ENOG4105C44 Serine transporter MC60_003715 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) MC60_003720 ENOG4105C9U ATP-dependent DNA helicase RecQ MC60_003725 ENOG4105CYN Serine protein kinase MC60_003730 ENOG4106AKX UPF0229 protein MC60_003735 ENOG4105ED1 spovr family MC60_003740 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) MC60_003745 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MC60_003750 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) MC60_003755 ENOG4105DQR SNARE associated Golgi MC60_003765 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) MC60_003780 ENOG4105D0C transport protein MC60_003785 ENOG4105E4C Lytic transglycosylase catalytic MC60_003805 ENOG4108MRH transcriptional regulatory protein MC60_003810 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MC60_003815 ENOG4105E2R ROK family MC60_003820 ENOG4105C8Q Methyl-accepting chemotaxis MC60_003830 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A MC60_003835 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B MC60_003840 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MC60_003855 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit MC60_003860 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein MC60_003865 ENOG4105DVI reductase, NrfD MC60_003870 ENOG4105DA4 cytochrome c-type biogenesis protein MC60_003875 ENOG4107QX9 Thiol disulfide interChange protein MC60_003880 ENOG4108DMF Cytochrome C biogenesis protein MC60_003885 ENOG41061WM D-Alanyl-D-Alanine MC60_003895 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein MC60_003900 ENOG4105MWK D-amino acid dehydrogenase, small subunit MC60_003905 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC60_003915 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) MC60_003920 ENOG4105DZ2 Transcriptional regulator MC60_003930 ENOG4105E0K tonB-dependent siderophore receptor MC60_003935 ENOG4105BZU Histidine kinase MC60_003940 ENOG4105BZU Histidine kinase MC60_003945 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) MC60_003950 ENOG4105CR8 Transcriptional regulator MC60_003955 ENOG4108RYK Nad-dependent epimerase dehydratase MC60_003965 ENOG4105C28 cystathionine MC60_003970 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) MC60_003990 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) MC60_003995 ENOG4105E98 transcriptional regulator DeoR family MC60_004010 ENOG4108UGV hypoxanthine phosphoribosyltransferase MC60_004020 ENOG4108RMJ sensory transduction regulator MC60_004030 ENOG4107104 thymidine kinase MC60_004035 ENOG4107S6Z Na H antiporter MC60_004045 ENOG4108WBT adenosyltransferase MC60_004050 ENOG4105VRT cytoplasmic protein MC60_004055 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) MC60_004060 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) MC60_004075 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) MC60_004080 ENOG4105CFV Tetratricopeptide repeat protein MC60_004090 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) MC60_004095 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) MC60_004100 ENOG4105CAT Cytidine monophosphate kinase MC60_004105 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) MC60_004110 ENOG4105DUM transcriptional regulator, lysR family MC60_004115 ENOG4105D2S major facilitator superfamily MC60_004130 ENOG4108DBC nitroreductase MC60_004135 ENOG4105CFC Transporter MC60_004140 ENOG4105BZU Histidine kinase MC60_004150 ENOG4105CBN LysR family transcriptional regulator MC60_004155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC60_004180 ENOG4107RGM aldo keto reductase MC60_004185 ENOG4105VFU Rna-binding protein MC60_004195 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) MC60_004205 ENOG4105HA9 of methanol dehydrogenase type MC60_004225 ENOG4105E14 MotA TolQ exbB proton channel MC60_004230 ENOG4105ER2 Ompa motb domain protein MC60_004235 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MC60_004240 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC60_004245 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC60_004250 ENOG4105GKE subunit e MC60_004255 ENOG4107QIZ NADH dehydrogenase MC60_004260 ENOG4108IEH NADH dehydrogenase subunit g MC60_004265 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) MC60_004270 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC60_004275 ENOG4107UFS subunit j MC60_004280 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC60_004285 ENOG4105D65 subunit l MC60_004290 ENOG4105C8S subunit m MC60_004295 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC60_004300 ENOG4107QIK phosphoribosylformylglycinamidine synthase MC60_004305 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) MC60_004310 ENOG4105VPD cellular component movement MC60_004315 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) MC60_004320 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) MC60_004325 ENOG4105N21 Membrane MC60_004330 ENOG4105CUT histidyl-tRNA synthetase MC60_004335 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) MC60_004340 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) MC60_004350 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MC60_004355 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) MC60_004360 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) MC60_004370 ENOG4108ZIT Ferredoxin, 2FE-2S MC60_004375 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB MC60_004380 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) MC60_004385 ENOG4108Z4V iron-sulfur cluster assembly MC60_004390 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins MC60_004395 ENOG4105C3J Cysteine desulfurase MC60_004400 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family MC60_004405 ENOG4105CVS RNA methyltransferase TrmH family, group 1 MC60_004410 ENOG4105XPQ lipid carrier protein MC60_004415 ENOG4105CFP Peptidase U32 MC60_004420 ENOG4106RZ4 Peptidase U32 MC60_004430 ENOG4105KHC sulfurtransferase MC60_004435 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MC60_004440 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MC60_004445 ENOG4105VIE preprotein translocase, subunit YajC MC60_004450 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) MC60_004455 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) MC60_004460 ENOG4105W87 Cbs domain MC60_004465 ENOG4105D3R alkyl hydroperoxide reductase MC60_004485 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) MC60_004515 ENOG4107SID ATP-dependent exodnase (exonuclease v) MC60_004565 ENOG4105DZR Type I site-specific deoxyribonuclease MC60_004575 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) MC60_004580 ENOG4106RHG Yeca family MC60_004595 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MC60_004600 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) MC60_004605 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) MC60_004610 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family MC60_004615 ENOG4105D0A hydroxylase MC60_004625 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) MC60_004635 ENOG4105E5M Multidrug resistance protein D MC60_004640 ENOG4105C3U ABC transporter MC60_004645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC60_004650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC60_004660 ENOG4105CYM Glutathione S-transferase MC60_004665 ENOG4108K3A Glutathione S-transferase MC60_004680 ENOG4105EIY sodium-type flagellar protein motY MC60_004690 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) MC60_004695 ENOG4105D3Y Na H antiporter MC60_004705 ENOG4105CC0 LysR family Transcriptional regulator MC60_004725 ENOG4105KA0 thioesterase Superfamily protein MC60_004735 ENOG4105CQB FAD linked oxidase domain protein MC60_004750 ENOG4105EE5 Membrane protein terC MC60_004755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MC60_004765 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) MC60_004770 ENOG4105D4U had-superfamily hydrolase, subfamily iia MC60_004780 ENOG4105CAQ asparagine synthetase MC60_004795 ENOG4108RXX maleylacetoacetate isomerase MC60_004805 ENOG4105F1J Homogentisate 1,2-dioxygenase MC60_004810 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase MC60_004820 ENOG4108W1A pseudouridine synthase MC60_004825 ENOG4105BZU Histidine kinase MC60_004830 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor MC60_004835 ENOG4105CR4 methylisocitrate lyase MC60_004840 ENOG4105BZN citrate synthase MC60_004845 ENOG4108I0Z Aconitate hydratase MC60_004850 ENOG4105C7F AcnD-accessory protein PrpF MC60_004865 ENOG4105CNM Receptor MC60_004875 ENOG4108MN8 Membrane MC60_004880 ENOG4105EM2 membrane MC60_004885 ENOG4108Z0T Part of a sulfur-relay system (By similarity) MC60_004890 ENOG4108S3P Sporulation domain protein MC60_004895 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MC60_004900 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) MC60_004905 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) MC60_004915 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MC60_004920 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) MC60_004925 ENOG4105YVM Phosphoesterase, PA-phosphatase related MC60_004930 ENOG4105D01 (LipO)protein MC60_004955 ENOG4105DKW ABC transporter MC60_004960 ENOG4105BZU Histidine kinase MC60_004970 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) MC60_004975 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) MC60_004985 ENOG4105C85 amino acid MC60_005025 ENOG4105C42 Type I secretion membrane fusion protein (HlyD MC60_005035 ENOG4105N5T Radical SAM Protein MC60_005040 ENOG4105CBC glutamate synthase MC60_005045 ENOG4105BZ8 glutamate synthase MC60_005050 ENOG4105CDA abc transporter atp-binding protein MC60_005055 ENOG4105DRP amino acid AbC transporter MC60_005060 ENOG4105EAB amino acid AbC transporter MC60_005095 ENOG4105C1J atp-dependent rna helicase MC60_005115 ENOG4107QS8 (LipO)protein MC60_005120 ENOG4106TD9 Diguanylate cyclase MC60_005125 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) MC60_005130 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain MC60_005135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain MC60_005140 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) MC60_005150 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase MC60_005155 ENOG4105E66 phosphoriboisomerase A MC60_005160 ENOG4108JQ1 Dehydrogenase MC60_005165 ENOG41080IJ Diacylglycerol kinase MC60_005170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) MC60_005180 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) MC60_005185 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) MC60_005200 ENOG4105CZX twitching motility protein MC60_005210 ENOG4105CE1 Ferrous iron transport protein b MC60_005220 ENOG4108ZJT translation initiation factor, Sui1 MC60_005260 ENOG410620I Diguanylate cyclase MC60_005280 ENOG4105C8N cysteinyl-tRNA synthetase MC60_005285 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) MC60_005295 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) MC60_005300 ENOG4105Y3U Transglycosylase-associated protein MC60_005305 ENOG4108WUH Transcriptional regulator, TetR family MC60_005310 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family MC60_005315 ENOG4107SDU Methyl-accepting chemotaxis MC60_005455 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) MC60_005460 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase MC60_005465 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MC60_005470 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) MC60_005570 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MC60_005575 ENOG4105WH1 Two component transcriptional regulator luxr family MC60_005580 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) MC60_005585 ENOG4105W49 UPF0434 protein MC60_005590 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) MC60_005595 ENOG4105BZ1 (ABC) transporter MC60_005600 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 MC60_005615 ENOG4105D7A ATP-binding protein MC60_005620 ENOG4105CGF Aromatic amino acid aminotransferase MC60_005635 ENOG4105DVT helicase MC60_005645 ENOG4105DGU Histone deacetylase MC60_005650 ENOG4108ISG Major Facilitator MC60_005655 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) MC60_005660 ENOG4105G6Z alkaline phosphatase MC60_005680 ENOG4105NXH GreA GreB family elongation factor MC60_005685 ENOG4105BZU Histidine kinase MC60_005690 ENOG4106TNF Periplasmic binding protein MC60_005695 ENOG4105E5Q amino acid AbC transporter MC60_005700 ENOG4105CDA abc transporter atp-binding protein MC60_005710 ENOG4105D5Q Arginine ornithine antiporter MC60_005715 ENOG4105C3R Methionine synthase MC60_005725 ENOG4105C37 (CBS) domain MC60_005735 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MC60_005740 ENOG4105E2Z phosphate ABC transporter (Permease MC60_005745 ENOG4105C8U phosphate abc transporter MC60_005750 ENOG4108Z6B deaminase MC60_005765 ENOG4107QP3 malate synthase g MC60_005770 ENOG4108I9X Isocitrate lyase MC60_005785 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) MC60_005790 ENOG4105CXB phosphoribosylaminoimidazole synthetase MC60_005795 ENOG4108V3E phosphoribosylglycinamide formyltransferase MC60_005800 ENOG4107QNR UPF0135 protein MC60_005805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_005810 ENOG4105BZU Histidine kinase MC60_005815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_005825 ENOG4105RH4 Glycine cleavage system transcriptional repressor MC60_005830 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) MC60_005835 ENOG4105C9X ppx gppa phosphatase MC60_005840 ENOG4105CJW magnesium transporter MC60_005855 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj MC60_005860 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) MC60_005865 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) MC60_005870 ENOG4105CGA flagellar basal-body rod protein FlgG MC60_005875 ENOG4108KPB Flagellar basal-body rod protein FlgF MC60_005880 ENOG4105BZE flagellar hook protein, FlgE MC60_005890 ENOG4108ZC9 flagellar basal-body rod protein flgc MC60_005895 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) MC60_005900 ENOG4105BZU Histidine kinase MC60_005905 ENOG4107R88 Chemotaxis protein (CheV) MC60_005910 ENOG4107ESN Flagella basal body P-ring formation protein flgA MC60_005925 ENOG4108RE9 Phosphodiesterase MC60_005930 ENOG4107QSI ABC, transporter MC60_005940 ENOG4105I08 Pseudouridine synthase MC60_005945 ENOG4105DHT Metal Dependent Phosphohydrolase MC60_005955 ENOG4108594 Permease of the drug metabolite transporter MC60_005960 ENOG4105E43 Extracellular solute-binding protein, family 5 MC60_005985 ENOG4105VEQ Cold shock protein MC60_005990 ENOG4107QSN dihydrolipoamide acetyltransferase MC60_005995 ENOG4105CPP Dehydrogenase, E1 component MC60_006000 ENOG4107RUY (E1 component), alpha subunit MC60_006015 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) MC60_006025 ENOG4108YXG UPF0502 protein MC60_006035 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) MC60_006040 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MC60_006045 ENOG4108J1Q MC60_006055 ENOG4105D3Q Sugar transferase MC60_006070 ENOG4105H63 Glycosyl transferase, family 2 MC60_006080 ENOG4105CPF Cell wall formation (By similarity) MC60_006100 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MC60_006110 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase MC60_006115 ENOG4105C1B dTDP-glucose 4-6-dehydratase MC60_006125 ENOG4105XJC Two component transcriptional regulator (Winged helix family MC60_006140 ENOG4106KNT transcriptional regulator MC60_006145 ENOG4105CA9 Pyruvate kinase MC60_006155 ENOG4105BZS acriflavin resistance protein MC60_006160 ENOG4107QPN acyl-Coa dehydrogenase MC60_006170 ENOG4107SSZ Phosphatase MC60_006210 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein MC60_006215 ENOG4105ENJ RND efflux system, outer membrane lipoprotein MC60_006220 ENOG4105BZS acriflavin resistance protein MC60_006225 ENOG4105C1P efflux transporter, rnd family, mfp subunit MC60_006230 ENOG4108IG5 Transcriptional regulator MC60_006245 ENOG4105C29 acyl-CoA thioesterase MC60_006250 ENOG4105FE9 pseudouridine synthase MC60_006255 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) MC60_006265 ENOG4107RTD sua5 ycio yrdc ywlc family protein MC60_006270 ENOG4105DB7 PHP domain protein MC60_006275 ENOG4105CRQ synthase (Component I) MC60_006280 ENOG4108EFP Anthranilate synthase component II MC60_006285 ENOG4108I0Q anthranilate phosphoribosyltransferase MC60_006290 ENOG4105DK0 Indole-3-glycerol phosphate synthase MC60_006295 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) MC60_006300 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) MC60_006315 ENOG4108J1Q MC60_006320 ENOG4105S2T inner membrane protein YbcI MC60_006345 ENOG4105JQN Transcriptional regulator MC60_006355 ENOG4106FTQ Taurine ABC transporter, periplasmic MC60_006360 ENOG4108ETV ABC transporter MC60_006365 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MC60_006370 ENOG4105E2B Taurine dioxygenase MC60_006375 ENOG4105KCV RNA signal recognition particle 4.5S RNA MC60_006380 ENOG4107RDB Major Facilitator MC60_006390 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MC60_006395 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) MC60_006400 ENOG4105CCU oxidase (Subunit III) MC60_006405 ENOG4105BZ9 Cytochrome C oxidase, subunit I MC60_006410 ENOG4105E2S oxidase) subunit II MC60_006415 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MC60_006420 ENOG4105CC0 LysR family Transcriptional regulator MC60_006440 ENOG4105NTK Transcriptional repressor Mpra MC60_006455 ENOG41090JD Blue (Type 1) copper domain protein MC60_006480 ENOG4105CGK Exodeoxyribonuclease III MC60_006490 ENOG4105EP1 Efflux transporter rnd family, mfp subunit MC60_006495 ENOG4108IJF Heavy metal efflux pump, CzcA MC60_006510 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) MC60_006515 ENOG4105BZU Histidine kinase MC60_006530 ENOG4105KFG YeeE YedE family protein MC60_006550 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase MC60_006565 ENOG4105WBN Transcriptional regulator (LacI family MC60_006580 ENOG4105D7K pfkb domain protein MC60_006590 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MC60_006595 ENOG4105CFG Acts as a chaperone (By similarity) MC60_006600 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MC60_006605 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) MC60_006610 ENOG4105BZU Histidine kinase MC60_006615 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) MC60_006625 ENOG4105DJY efflux transporter, rnd family, mfp subunit MC60_006630 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) MC60_006635 ENOG4105ENJ RND efflux system, outer membrane lipoprotein MC60_006640 ENOG4105Q26 Siderophore-interacting protein MC60_006655 ENOG4105W8I Transcriptional regulator MC60_006660 ENOG4105BZC d-serine deaminase MC60_006670 ENOG4108HMX isocitrate dehydrogenase (NADP) MC60_006700 ENOG4108W0I acetyltransferase MC60_006705 ENOG4108R99 pseudouridine synthase MC60_006715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) MC60_006720 ENOG41075W9 High frequency lysogenization protein HflD homolog MC60_006725 ENOG4107QTF adenylosuccinate lyase MC60_006730 ENOG4105EZE Cupin 4 family protein MC60_006735 ENOG4105CA9 Pyruvate kinase MC60_006740 ENOG4105EGS Mechanosensitive ion channel MC60_006760 ENOG4105C2W permease MC60_006770 ENOG4107R1I NAD-dependent malic enzyme MC60_006775 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) MC60_006780 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b MC60_006785 ENOG4105DR8 Membrane MC60_006790 ENOG4108ESY Metal dependent phosphohydrolase MC60_006800 ENOG4107SDU Methyl-accepting chemotaxis MC60_006820 ENOG4105E18 UPF0276 protein MC60_006835 ENOG4105C94 Transporter MC60_006850 ENOG4108J1Q MC60_006865 ENOG4105D98 threonine synthase MC60_006870 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) MC60_006885 ENOG4106FVC RNA methyltransferase MC60_006890 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) MC60_006905 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) MC60_006915 ENOG41065U4 response regulator MC60_006930 ENOG4108JJ9 ABC, transporter MC60_006935 ENOG4108JJ8 (ABC) transporter MC60_006955 ENOG4108R96 Methyltransferase, YaeB family MC60_006970 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) MC60_006975 ENOG4105C6T cysteine synthase MC60_006980 ENOG4105KZ7 phosphocarrier protein hpr MC60_006990 ENOG4105C5Y PTS System MC60_006995 ENOG4105CPW cytochrome b561 MC60_007000 ENOG4105EYH Exonuclease MC60_007005 ENOG4107RH8 nuclease SbcCD subunit D MC60_007010 ENOG4105WCN acetyltransferase MC60_007015 ENOG4105DH7 May be involved in recombination (By similarity) MC60_007025 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) MC60_007030 ENOG4105CKD glutathione-regulated potassium-efflux system protein MC60_007035 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_007065 ENOG4105CJP fad dependent oxidoreductase MC60_007070 ENOG4107VRI Transcriptional regulator MC60_007075 ENOG4105C26 Dehydrogenase MC60_007080 ENOG4108JPW Aminotransferase MC60_007085 ENOG4105CUB amino acid MC60_007090 ENOG4105CUB amino acid MC60_007105 ENOG4108V1T peptidylprolyl cis-trans isomerase MC60_007110 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b MC60_007115 ENOG4105BZU Histidine kinase MC60_007120 ENOG4105XIQ Protein of unknown function (DUF2517) MC60_007140 ENOG4105BZU Histidine kinase MC60_007150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MC60_007165 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) MC60_007170 ENOG4107TT5 NLP P60 protein MC60_007175 ENOG4107YAK holo-(acyl carrier protein) synthase 2 MC60_007180 ENOG4107QR8 Thioredoxin MC60_007190 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) MC60_007195 ENOG4105CIY formyltetrahydrofolate deformylase MC60_007220 ENOG4105E4C Lytic transglycosylase catalytic MC60_007230 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MC60_007235 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) MC60_007240 ENOG4105EP9 oxidoreductase MC60_007265 ENOG4105CCT upf0313 protein MC60_007270 ENOG4105BZS acriflavin resistance protein MC60_007280 ENOG4105BZU Histidine kinase MC60_007285 ENOG4105D78 K07001 NTE family protein MC60_007290 ENOG4105C8J )-transporter MC60_007305 ENOG4105UYK outer membrane protein a MC60_007315 ENOG4105UYK outer membrane protein a MC60_007320 ENOG4107R1I NAD-dependent malic enzyme MC60_007325 ENOG41075H3 AraC family transcriptional regulator MC60_007335 ENOG4105RKX Protein of unknown function (DUF2498) MC60_007340 ENOG4105BZU Histidine kinase MC60_007345 ENOG4105C2W permease MC60_007350 ENOG4108KMH lipoate-protein ligase a MC60_007355 ENOG4105BZG amino acid carrier protein MC60_007375 ENOG4105PTV Nudix Hydrolase MC60_007385 ENOG4105CDA abc transporter atp-binding protein MC60_007390 ENOG4105DRP amino acid AbC transporter MC60_007395 ENOG4105EZ7 amino acid ABC transporter MC60_007410 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) MC60_007415 ENOG4105CJ1 ABC, transporter MC60_007420 ENOG4108V1T peptidylprolyl cis-trans isomerase MC60_007435 ENOG4106N3A copper homeostasis protein cutc MC60_007440 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) MC60_007450 ENOG4105ERG peptidase m48, ste24p MC60_007460 ENOG4105BZU Histidine kinase MC60_007465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC60_007470 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase MC60_007475 ENOG4105BZU Histidine kinase MC60_007480 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family MC60_007485 ENOG4105C26 Dehydrogenase MC60_007495 ENOG4108IPJ Membrane MC60_007500 ENOG4106YYS transcriptional regulatory protein MC60_007505 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MC60_007515 ENOG4105J12 Multidrug resistance protein mdtN MC60_007540 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) MC60_007545 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase MC60_007555 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MC60_007560 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) MC60_007565 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) MC60_007570 ENOG4105EXN Sulfate transport protein CysZ MC60_007575 ENOG4105EN6 Membrane MC60_007585 ENOG4105EAQ (twin-arginine translocation) pathway signal MC60_007590 ENOG4105DIT ErfK YbiS YcfS YnhG family protein MC60_007620 ENOG4107T9C Alpha amylase catalytic region MC60_007630 ENOG4107T9C Alpha amylase catalytic region MC60_007640 ENOG4108W5X Transcriptional Regulator, LuxR family MC60_007675 ENOG4105BZU Histidine kinase MC60_007680 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) MC60_007685 ENOG4105C9K Endothelin-converting enzyme 1 MC60_007695 ENOG4105C5H ABC transporter MC60_007705 ENOG4105DVH amino acid MC60_007710 ENOG4105C44 Serine transporter MC60_007715 ENOG4105EQ2 LysR family Transcriptional regulator MC60_007725 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) MC60_007730 ENOG4105C0B DNA polymerase III (alpha subunit) MC60_007735 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MC60_007740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) MC60_007745 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) MC60_007750 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) MC60_007755 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) MC60_007760 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) MC60_007770 ENOG4105DZP Membrane-associated zinc metalloprotease MC60_007775 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) MC60_007780 ENOG4105KNE Phosphatidate cytidylyltransferase MC60_007785 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MC60_007790 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) MC60_007795 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) MC60_007800 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) MC60_007805 ENOG4105CE9 30S ribosomal protein S2 MC60_007810 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MC60_007815 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) MC60_007820 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) MC60_007825 ENOG4108T8E UPF0325 protein MC60_007830 ENOG4105CI1 PTS System MC60_007835 ENOG4107W52 maltose operon periplasmic protein MC60_007840 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) MC60_007845 ENOG4105QDK Flavodoxin MC60_007850 ENOG4105DR9 pseudouridine synthase MC60_007855 ENOG4105WP7 tRNA pseudouridine synthase C MC60_007880 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein MC60_007885 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) MC60_007890 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) MC60_007900 ENOG4105BZU Histidine kinase MC60_007905 ENOG4105EWT decarboxylase family MC60_007910 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease MC60_007915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) MC60_007925 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) MC60_007940 ENOG4105ETT transcriptional Regulator, LysR family MC60_007945 ENOG4105C8Q Methyl-accepting chemotaxis MC60_007950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MC60_007965 ENOG4105CJ2 (LipO)protein MC60_007970 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) MC60_007975 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_007980 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_007985 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_007990 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_007995 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_008000 ENOG4105M85 Bola protein MC60_008005 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) MC60_008015 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) MC60_008025 ENOG4105EYM Major Facilitator superfamily MC60_008030 ENOG4105DRB nucleoside-specific channel-forming protein MC60_008035 ENOG4108VPT UPF0234 protein MC60_008040 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) MC60_008045 ENOG4107S0N DJ-1 family MC60_008095 ENOG4105CS6 Rhs element vgr protein MC60_008100 ENOG4108WC9 type VI secretion system effector, hcp1 family MC60_008105 ENOG4105VJY transcriptional regulator MC60_008110 ENOG4105CHH sulfate transporter MC60_008115 ENOG4105BZU Histidine kinase MC60_008120 ENOG4105E3W Two component transcriptional regulator (Winged helix family MC60_008125 ENOG4105C1P efflux transporter, rnd family, mfp subunit MC60_008130 ENOG4105BZS acriflavin resistance protein MC60_008150 ENOG4105ETE Transcriptional regulator (LacI family MC60_008155 ENOG4107FKK extracellular solute-binding protein family 1 MC60_008170 ENOG4105E08 Glycoside hydrolase, family 9 MC60_008175 ENOG4105VZJ PTS System MC60_008185 ENOG4105CS2 ec 3.2.1.21 MC60_008190 ENOG4105VCP PTS System MC60_008210 ENOG4105CMR udp-glucose 4-epimerase MC60_008220 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) MC60_008225 ENOG4108RMU ferritin dps family protein MC60_008250 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MC60_008265 ENOG4105EMU Dehydrogenase MC60_008275 ENOG4105CVP deoxyribo-dipyrimidine photolyase MC60_008280 ENOG4108XDN Transcriptional regulator MC60_008285 ENOG4107SEY Conserved Protein MC60_008350 ENOG4107RDJ Sulfotransferase MC60_008365 ENOG4105D8V Glucose sorbosone dehydrogenase MC60_008375 ENOG4105MVE transcriptional regulator MC60_008385 ENOG4105G63 Type III effector Hrp-dependent MC60_008390 ENOG4105FB2 class II Aldolase MC60_008395 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) MC60_008400 ENOG4105EXW epimerase dehydratase MC60_008405 ENOG4105C6Z Gluconate MC60_008415 ENOG4105C8Q Methyl-accepting chemotaxis MC60_008425 ENOG4105E1F short-chain dehydrogenase reductase MC60_008450 ENOG4105CTD carboxy-peptidase MC60_008470 ENOG4105XDF Protein of unknown function (DUF1272) MC60_008480 ENOG4105CFP Peptidase U32 MC60_008485 ENOG4105N14 lysine exporter protein LysE YggA MC60_008495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MC60_008520 ENOG4108NJZ Sensory box GGDEF EAL domain protein MC60_008530 ENOG4105DB1 molybdopterin oxidoreductase MC60_008535 ENOG4106WHD Tetrathionate reductase MC60_008540 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein MC60_008545 ENOG4105BZU Histidine kinase MC60_008550 ENOG4108ZXC Two component transcriptional regulator, luxr family MC60_008555 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) MC60_008560 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC60_008565 ENOG4105CW7 secretion protein, HlyD family MC60_008585 ENOG4105C26 Dehydrogenase MC60_008590 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MC60_008595 ENOG4105CDU Replicative dna helicase MC60_008605 ENOG4105CGH 5'-nucleotidase MC60_008625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_008630 ENOG4108V1T peptidylprolyl cis-trans isomerase MC60_008640 ENOG4105VRX Protein slyX homolog MC60_008645 ENOG4108YZY peptidylprolyl cis-trans isomerase MC60_008650 ENOG4105VKU nucleicacid-binding protein MC60_008660 ENOG4107R88 Chemotaxis protein (CheV) MC60_008665 ENOG4105DNZ Alpha Beta Hydrolase MC60_008675 ENOG4105YP7 UPF0270 protein MC60_008680 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) MC60_008695 ENOG4108UKZ OsmC family MC60_008700 ENOG4107RYR Transcriptional regulator, Crp Fnr family MC60_008705 ENOG4105DHI Methyltransferase MC60_008715 ENOG4105BZU Histidine kinase MC60_008720 ENOG4105D8G Major Facilitator superfamily MC60_008745 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related MC60_008750 ENOG41090JE Utilization Protein MC60_008760 ENOG4105EHG Permease protein MC60_008775 ENOG4105C6Y Udp-glucose 6-dehydrogenase MC60_008785 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) MC60_008795 ENOG4105CKK Glycosyl transferase, family 2 MC60_008805 ENOG4105E4C Lytic transglycosylase catalytic MC60_008810 ENOG4105C5H ABC transporter MC60_008820 ENOG4105C7N Xanthine uracil vitamin C permease MC60_008825 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) MC60_008830 ENOG4108S0S Nucleotidyl transferase MC60_008835 ENOG4105EHM Aminoglycoside phosphotransferase MC60_008840 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) MC60_008850 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) MC60_008855 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MC60_008860 ENOG4105NWN ApaG protein MC60_008865 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) MC60_008875 ENOG4105DEN Luciferase family MC60_008880 ENOG4108ESY Metal dependent phosphohydrolase MC60_008885 ENOG4105DWD nucleoside recognition domain protein MC60_008890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MC60_008895 ENOG4105K46 50S ribosomal protein l27 MC60_008900 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) MC60_008905 ENOG4105EAH synthase MC60_008915 ENOG4105EPW hflc protein MC60_008920 ENOG4107QJR hflk protein MC60_008925 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MC60_008930 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) MC60_008935 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) MC60_008940 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) MC60_008945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MC60_008950 ENOG4105K8N protein family UPF0079, ATPase MC60_008955 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) MC60_008975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) MC60_008980 ENOG4108UMI ABC transporter, permease MC60_008985 ENOG4105D01 (LipO)protein MC60_008990 ENOG4105MDZ Transcriptional activator rfaH MC60_008995 ENOG4107SDU Methyl-accepting chemotaxis MC60_009000 ENOG4105BZU Histidine kinase MC60_009005 ENOG4105BZU Histidine kinase MC60_009020 ENOG4105BZU Histidine kinase MC60_009040 ENOG4108Q67 UPF0319 protein MC60_009045 ENOG4105EXG Transcriptional regulator MC60_009055 ENOG4107QWK SAICAR synthetase MC60_009060 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) MC60_009065 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MC60_009070 ENOG4105RH4 Glycine cleavage system transcriptional repressor MC60_009075 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MC60_009080 ENOG4105XWI UPF0304 protein MC60_009085 ENOG4105PQ6 UPF0208 membrane protein MC60_009090 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MC60_009095 ENOG4105C6K Malic enzyme MC60_009100 ENOG4108ZP8 Acetolactate synthase small subunit MC60_009105 ENOG4105C7K acetolactate synthase MC60_009120 ENOG4105YVM Phosphoesterase, PA-phosphatase related MC60_009130 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) MC60_009140 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MC60_009145 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MC60_009160 ENOG4105DP9 ABC transporter MC60_009165 ENOG4106SMU thiamine transporter membrane protein MC60_009170 ENOG4107T0D ABC, transporter MC60_009175 ENOG4108IAB Phoh family MC60_009185 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MC60_009215 ENOG4107QWG 2-Nitropropane dioxygenase MC60_009240 ENOG4105E0F Histidine kinase MC60_009245 ENOG4105E3W Two component transcriptional regulator (Winged helix family MC60_009250 ENOG4105DJY efflux transporter, rnd family, mfp subunit MC60_009255 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) MC60_009265 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase MC60_009285 ENOG4106B0W Curli production assembly transport component CsgG MC60_009295 ENOG4107Y60 (LipO)protein MC60_009300 ENOG4105BZU Histidine kinase MC60_009305 ENOG4105C1J atp-dependent rna helicase MC60_009315 ENOG4106AXJ AraC family transcriptional regulator MC60_009335 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) MC60_009340 ENOG4107RRE RNA-directed DNA polymerase MC60_009345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MC60_009350 ENOG4105DWY Agmatine deiminase MC60_009365 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MC60_009370 ENOG4108MJ3 acetyltransferase MC60_009375 ENOG4105C09 Bile acid MC60_009390 ENOG4105BZU Histidine kinase MC60_009395 ENOG4105BZU Histidine kinase MC60_009400 ENOG4105EV2 VWA domain protein interacting with AAA ATPase MC60_009415 ENOG41080E2 ribosomal-protein-alanine acetyltransferase MC60_009425 ENOG4108IQE Amp-dependent synthetase and ligase MC60_009450 ENOG4107SQD Transcriptional regulator, GntR family MC60_009465 ENOG4105C8J )-transporter MC60_009470 ENOG4105C8J )-transporter MC60_009485 ENOG4108K4B hydrolase MC60_009500 ENOG4105EW9 transcriptional regulator AsnC family MC60_009515 ENOG4105K56 Transcriptional regulator MC60_009520 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein MC60_009540 ENOG4105E0X reductase MC60_009550 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) MC60_009555 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) MC60_009565 ENOG4105DSB aldose 1-epimerase MC60_009570 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) MC60_009575 ENOG4105C8Q Methyl-accepting chemotaxis MC60_009650 ENOG4105UFD tol-pal system protein YbgF MC60_009655 ENOG4105KCK Peptidoglycan-associated lipoprotein MC60_009660 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) MC60_009670 ENOG4105M8F Biopolymer transport protein exbD tolR MC60_009675 ENOG4105E02 MotA TolQ exbB proton channel MC60_009680 ENOG4107YD3 Thioesterase MC60_009685 ENOG4105KJB cyd operon protein YbgE MC60_009695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MC60_009700 ENOG4105C4M (Ubiquinol oxidase) subunit I MC60_009705 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) MC60_009710 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) MC60_009715 ENOG4105C8Q Methyl-accepting chemotaxis MC60_009720 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) MC60_009725 ENOG41083X2 DNA polymerase III, epsilon subunit MC60_009730 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr MC60_009745 ENOG4105E39 Enoyl-CoA hydratase MC60_009750 ENOG4106WH9 Protein of unknown function (DUF2753) MC60_009760 ENOG4107QSI ABC, transporter MC60_009770 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor MC60_009775 ENOG4105C1J atp-dependent rna helicase MC60_009780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) MC60_009810 ENOG4105EJG cellulose synthase MC60_009815 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) MC60_009820 ENOG4107EEX Cellulose synthase regulator protein MC60_009830 ENOG4105UTS cellulose synthase operon protein YhjQ MC60_009840 ENOG4105D1V cellulose synthase operon protein YhjU MC60_009845 ENOG4105CGF Aromatic amino acid aminotransferase MC60_009860 ENOG41076CZ activating enzyme MC60_009865 ENOG4105G0K glycine radical enzyme YjjI family MC60_009890 ENOG4105C8Q Methyl-accepting chemotaxis MC60_009895 ENOG4108M1A Chitin-binding protein MC60_009900 ENOG4107R11 Transcriptional regulator MC60_009905 ENOG4108IJ6 ABC transporter MC60_009910 ENOG4105ECW sulfate abc transporter MC60_009915 ENOG4108I5D sulfate abc transporter MC60_009925 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein MC60_009960 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) MC60_009965 ENOG4105D3G Pseudouridine synthase MC60_009975 ENOG4105BZU Histidine kinase MC60_009985 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MC60_009990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) MC60_010000 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 MC60_010005 ENOG4108IJ0 Aspartate ammonia-lyase MC60_010010 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter MC60_010015 ENOG4105D9M gamma-glutamylcysteine synthetase MC60_010025 ENOG4105W39 Membrane MC60_010040 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) MC60_010060 ENOG4105DP0 ferredoxin-NADP reductase MC60_010065 ENOG4105K9Q Binds to the 23S rRNA (By similarity) MC60_010070 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) MC60_010075 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) MC60_010080 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) MC60_010085 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MC60_010090 ENOG4107YB6 acetyltransferase, (GNAT) family MC60_010100 ENOG4105C2N RNA methyltransferase TrmH family group 3 MC60_010105 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) MC60_010110 ENOG4106TD9 Diguanylate cyclase MC60_010115 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) MC60_010125 ENOG4108YZA Nitrogen regulatory protein pii MC60_010130 ENOG4105C4K Nad synthetase MC60_010165 ENOG4106855 Competence protein MC60_010170 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) MC60_010175 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase MC60_010180 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) MC60_010185 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) MC60_010190 ENOG4105DTN riboflavin biosynthesis protein ribF MC60_010195 ENOG4105CJR Integral membrane protein (MviN MC60_010200 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) MC60_010205 ENOG41080HT Transcriptional regulator, arsr family MC60_010210 ENOG41063Z6 transcriptional regulator, lysR family MC60_010220 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MC60_010225 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) MC60_010230 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) MC60_010235 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase MC60_010240 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MC60_010255 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) MC60_010260 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) MC60_010265 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) MC60_010270 ENOG4105K5M 30s ribosomal protein S16 MC60_010275 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MC60_010280 ENOG4106KVJ cytochrome C assembly protein MC60_010285 ENOG4108JU6 CBS domain protein MC60_010295 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MC60_010300 ENOG4108UV7 flagellar protein motX MC60_010305 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MC60_010310 ENOG4105DMR ABC, transporter MC60_010315 ENOG4105GBT ABC transporter MC60_010320 ENOG4106TNF Periplasmic binding protein MC60_010325 ENOG4105E5Z arginine transporter ATP-binding subunit MC60_010330 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) MC60_010335 ENOG4105EZR dyp-type peroxidase family protein MC60_010340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC60_010350 ENOG4107QKW extracellular solute-binding protein family 1 MC60_010355 ENOG4108YZA Nitrogen regulatory protein pii MC60_010360 ENOG4108YZN class I peptide chain release factor MC60_010370 ENOG4105D9N nucleoside MC60_010375 ENOG4105HEI LysR family (Transcriptional regulator MC60_010390 ENOG4105BZW Glycerate kinase MC60_010395 ENOG4107QQ0 gntp family MC60_010400 ENOG4107VHA regulatoR MC60_010405 ENOG4105XTV UPF0231 protein MC60_010425 ENOG4105VZ9 UPF0235 protein MC60_010430 ENOG4108VIA integral membrane protein MC60_010435 ENOG4105II7 pyrroline-5-carboxylate reductase MC60_010440 ENOG4105DFA alanine racemase domain protein MC60_010445 ENOG4105CZX twitching motility protein MC60_010450 ENOG4105CZX twitching motility protein MC60_010455 ENOG4105D1Q UPF0246 protein MC60_010460 ENOG4105C1J atp-dependent rna helicase MC60_010465 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) MC60_010470 ENOG4105CWM branched-chain amino acid transport system II carrier protein MC60_010485 ENOG4105MYN Zinc uptake regulation protein MC60_010490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) MC60_010505 ENOG4105K70 DNA-binding protein MC60_010510 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor MC60_010520 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MC60_010535 ENOG4105EAC phosphoserine phosphatase MC60_010545 ENOG4105BZU Histidine kinase MC60_010550 ENOG4105MQ2 17 kDa surface antigen MC60_010555 ENOG4105D3A purine nucleoside phosphorylase DeoD-type MC60_010560 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) MC60_010565 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) MC60_010570 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) MC60_010580 ENOG4105D9N nucleoside MC60_010585 ENOG4105EYA deoxyribonuclease MC60_010590 ENOG4106855 Competence protein MC60_010600 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MC60_010610 ENOG4105BZU Histidine kinase MC60_010630 ENOG4108K5H permease YjgP YjgQ family protein MC60_010635 ENOG4108M8S permease YjgP YjgQ family protein MC60_010640 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) MC60_010645 ENOG4105MYG DNA polymerase iii, chi subunit MC60_010650 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) MC60_010660 ENOG4106W5V Membrane MC60_010665 ENOG41061WM D-Alanyl-D-Alanine MC60_010700 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) MC60_010705 ENOG4105CFH Aspartokinase MC60_010710 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MC60_010715 ENOG4105Y3E Modulates RecA activity (By similarity) MC60_010720 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) MC60_010725 ENOG4107TH8 cina domain protein MC60_010735 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) MC60_010755 ENOG4105R2J Conserved Protein MC60_010765 ENOG4105DR5 peptidase MC60_010785 ENOG4105NXV High-affinity zinc uptake system protein MC60_010790 ENOG4105FDK ABC transporter MC60_010795 ENOG4105FAV ABC, transporter MC60_010800 ENOG4105ETT transcriptional Regulator, LysR family MC60_010810 ENOG4108RG0 uracil-dna glycosylase MC60_010815 ENOG4105FR1 rard protein MC60_010820 ENOG41082IR Excinuclease ABC C subunit domain protein MC60_010835 ENOG41087YS Phage shock protein A MC60_010840 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase MC60_010860 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MC60_010870 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MC60_010905 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC60_010910 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC60_010915 ENOG4105DSW Fusaric acid resistance protein MC60_010920 ENOG4105Y49 secretion protein, HlyD family MC60_010940 ENOG4105IPS esterase MC60_010945 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) MC60_010950 ENOG4108SX3 cytoplasmic protein MC60_010955 ENOG41087AY ADP-Ribose pyrophosphatase MC60_010960 ENOG4105DFG type I secretion outer membrane protein MC60_010965 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) MC60_010970 ENOG4105D1S lipid A biosynthesis MC60_010975 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic MC60_010980 ENOG4108ZUB Lysine exporter protein (Lyse ygga) MC60_010985 ENOG4105VJY transcriptional regulator MC60_010990 ENOG4105NNS Autoinducer synthesis protein MC60_010995 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) MC60_011000 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) MC60_011005 ENOG4105CTS PTS system mannitol-specific MC60_011010 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase MC60_011015 ENOG4105E61 Mannitol repressor protein MC60_011020 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) MC60_011040 ENOG4108UPT UPF0178 protein MC60_011055 ENOG4105D9N nucleoside MC60_011060 ENOG4105C1J atp-dependent rna helicase MC60_011080 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MC60_011085 ENOG4105E4F Isochorismate synthase MC60_011090 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) MC60_011095 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) MC60_011100 ENOG4108IPT Naphthoate synthase MC60_011105 ENOG4105DNI Converts SHCHC to OSB (By similarity) MC60_011110 ENOG4105CEY Amp-dependent synthetase and ligase MC60_011120 ENOG4108UB4 uncharacterized protein ygjQ MC60_011125 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MC60_011135 ENOG4107IFA Lipase (EC 3.1.1.3) MC60_011165 ENOG4108IQK o-acetylhomoserine MC60_011175 ENOG4108I6A alcohol dehydrogenase MC60_011190 ENOG4105EMU Dehydrogenase MC60_011210 ENOG4105KT7 mgtC SapB transporter MC60_011225 ENOG4105E0M Sulfatase MC60_011230 ENOG4108YXU transcriptional regulator AsnC family MC60_011240 ENOG4105CVG Homoserine O-transsuccinylase MC60_011250 ENOG4108I62 cina-like protein MC60_011255 ENOG4107K5X Membrane-bound metal-dependent hydrolase MC60_011270 ENOG410667J hydrolase MC60_011275 ENOG4108Z86 Glutamine amidotransferase MC60_011285 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant MC60_011290 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC60_011300 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) MC60_011305 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MC60_011315 ENOG4105XQ6 frataxin-like protein MC60_011320 ENOG4106CJB Phospholipase Carboxylesterase MC60_011325 ENOG4107T0K Adenylate cyclase MC60_011330 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) MC60_011335 ENOG41076E6 Uroporphyrinogen-III Synthase MC60_011340 ENOG4105ECF c-methyltransferase MC60_011345 ENOG410601J HemY protein MC60_011350 ENOG4105KRS Proteinase inhibitor MC60_011355 ENOG4105CBT Fructose-1,6-bisphosphatase MC60_011365 ENOG4105DMQ Methyltransferase MC60_011375 ENOG4105E0K tonB-dependent siderophore receptor MC60_011390 ENOG4105KVH Transcriptional regulator MC60_011395 ENOG4105N0V mono-oxygenase ydhR MC60_011410 ENOG4108TPP exopolysaccharide synthesis MC60_011415 ENOG4105BZU Histidine kinase MC60_011420 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) MC60_011425 ENOG4105EQK -acetyltransferase MC60_011435 ENOG4105D41 biosynthesis protein thiH MC60_011440 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) MC60_011450 ENOG4105D06 uba thif-type nad fad binding protein MC60_011455 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) MC60_011460 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) MC60_011475 ENOG4105ETX regulatoR MC60_011485 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) MC60_011495 ENOG4105C3R Methionine synthase MC60_011500 ENOG4105EEQ Na H antiporter MC60_011520 ENOG4105CGZ zinc metallopeptidase MC60_011530 ENOG4105CSH Transporter MC60_011545 ENOG4105D1U peptidase U62 modulator of DNA gyrase MC60_011555 ENOG4105QD6 exported protein MC60_011560 ENOG4105C03 ribonuclease MC60_011565 ENOG4108Z03 MAF-like protein MC60_011570 ENOG4105VQ7 Rod shape-determining protein MreD MC60_011575 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) MC60_011580 ENOG4105DFF Rod shape-determining protein mreb MC60_011610 ENOG4108VAU general secretion pathway protein G MC60_011625 ENOG4105D7Q type ii secretion system MC60_011645 ENOG4105GVR general secretion pathway protein D MC60_011680 ENOG4107XTP (EAL) domain protein MC60_011685 ENOG4105EWV Sodium calcium exchanger membrane region MC60_011690 ENOG4105C84 Histidine ammonia-lyase MC60_011695 ENOG4105CGP Urocanate hydratase MC60_011700 ENOG41088SP formiminoglutamate hydrolase MC60_011705 ENOG4105CI2 imidazolone-5-propionate hydrolase MC60_011710 ENOG4105CZE histidine utilization repressor MC60_011715 ENOG41077A9 carbonic anhydrase MC60_011720 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC60_011725 ENOG4105CRP Part of the ABC transporter FtsEX involved in MC60_011730 ENOG4105CAK Cell division ATP-binding protein ftsE MC60_011735 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MC60_011740 ENOG4106H78 methyltransferase MC60_011750 ENOG4108Y73 Membrane MC60_011755 ENOG4105EJ2 Transcriptional regulator MC60_011765 ENOG4107RZC phospholipase d MC60_011770 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) MC60_011780 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) MC60_011790 ENOG41076UM multiple antibiotic resistance (MarC)-related protein MC60_011795 ENOG4105VVZ metal-binding protein MC60_011810 ENOG4105CR8 Transcriptional regulator MC60_011825 ENOG4107FS9 Membrane MC60_011845 ENOG4105CUG Oligopeptidase b MC60_011860 ENOG4105EMU Dehydrogenase MC60_011865 ENOG4106NZI LysR family Transcriptional regulator MC60_011870 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein MC60_011925 ENOG4108ZT0 50S ribosomal protein l17 MC60_011930 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MC60_011935 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) MC60_011940 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) MC60_011945 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MC60_011950 ENOG41067V7 50S ribosomal protein L36 MC60_011955 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MC60_011960 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) MC60_011965 ENOG4105VPB 50S ribosomal protein L30 MC60_011970 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) MC60_011975 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) MC60_011980 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) MC60_011985 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) MC60_011990 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) MC60_011995 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MC60_012000 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) MC60_012005 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) MC60_012010 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal MC60_012015 ENOG41083MP 50s ribosomal protein l29 MC60_012020 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) MC60_012025 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) MC60_012030 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) MC60_012035 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) MC60_012040 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MC60_012045 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) MC60_012050 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) MC60_012055 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) MC60_012060 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) MC60_012070 ENOG4105E0F Histidine kinase MC60_012075 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC60_012080 ENOG4108RRZ Transcription elongation factor GreB MC60_012085 ENOG4105BZM domain protein MC60_012100 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MC60_012105 ENOG4105MJ2 Competence protein MC60_012110 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) MC60_012115 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase MC60_012120 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) MC60_012125 ENOG4107YZP Rhodanese domain protein MC60_012130 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) MC60_012135 ENOG41063SB peptidase MC60_012145 ENOG4105DIQ Transcriptional regulator MC60_012160 ENOG4108UHU Aldolase MC60_012165 ENOG4105C01 Dihydroxy-acid dehydratase MC60_012170 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family MC60_012175 ENOG4105C6Z Gluconate MC60_012180 ENOG4105JIM Phosphatidylserine synthase MC60_012185 ENOG4105CB5 ATP-dependent DNA helicase recG MC60_012195 ENOG4105SUU thioesterase domain MC60_012205 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) MC60_012210 ENOG4107S2Z UPF0761 membrane protein MC60_012220 ENOG4105C5F glutamine synthetase MC60_012230 ENOG4105CUX Signal transduction histidine kinase MC60_012235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_012240 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) MC60_012245 ENOG4105D4P Coproporphyrinogen iii oxidase MC60_012250 ENOG4105XCT Protein of unknown function (DUF2489) MC60_012255 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) MC60_012260 ENOG4106RE7 Cytochrome MC60_012265 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) MC60_012270 ENOG4105E2X shikimate dehydrogenase MC60_012275 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) MC60_012280 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MC60_012285 ENOG4108WI1 Dna topoisomerase MC60_012290 ENOG4108RPN Protein smg homolog MC60_012295 ENOG4105C79 DNA protecting protein DprA MC60_012305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MC60_012310 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) MC60_012315 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B MC60_012320 ENOG4105C1A potassium transporter peripheral membrane MC60_012325 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) MC60_012330 ENOG4105CGY Dna recombination protein MC60_012350 ENOG4108MGF sugar kinase MC60_012355 ENOG4107R11 Transcriptional regulator MC60_012360 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MC60_012365 ENOG4105C26 Dehydrogenase MC60_012375 ENOG4108JCI Transcriptional regulator MC60_012380 ENOG4105C26 Dehydrogenase MC60_012385 ENOG4105FR1 rard protein MC60_012390 ENOG4105ECQ AraC Family Transcriptional Regulator MC60_012400 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) MC60_012410 ENOG41090KR LysR family transcriptional Regulator MC60_012430 ENOG41061EV selenium-binding protein YdfZ MC60_012445 ENOG4105HEI LysR family (Transcriptional regulator MC60_012450 ENOG4108UK5 Transposase MC60_012460 ENOG4105C4R Atp-dependent dna helicase MC60_012475 ENOG4105DIH basic membrane MC60_012480 ENOG4108JQ9 ABC transporter MC60_012485 ENOG4105UIB (ABC) transporter MC60_012495 ENOG4105CC0 LysR family Transcriptional regulator MC60_012505 ENOG4105C4W S-formylglutathione hydrolase MC60_012525 ENOG4105DHU Bile acid MC60_012530 ENOG4105E5D amino acid MC60_012535 ENOG4108Y51 tRNA-binding protein MC60_012540 ENOG4105E5D amino acid MC60_012545 ENOG4105FK9 beta-D-galactosidase beta subunit MC60_012550 ENOG4105CNT hydrolase family 2 MC60_012555 ENOG4105CQ4 Transcriptional regulator MC60_012590 ENOG4108Z0R Transferase MC60_012595 ENOG4105C2M dna polymerase I MC60_012600 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain MC60_012605 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) MC60_012615 ENOG4105D7W serine acetyltransferase MC60_012620 ENOG41076HS cation diffusion facilitator family transporter MC60_012625 ENOG4105E3W Two component transcriptional regulator (Winged helix family MC60_012630 ENOG4105E0F Histidine kinase MC60_012635 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) MC60_012640 ENOG4107R73 Mate efflux family protein MC60_012655 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) MC60_012660 ENOG4105E55 glycerol-3-phosphate acyltransferase MC60_012665 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) MC60_012670 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) MC60_012675 ENOG4105X6C Flagellar basal body-associated protein FliL MC60_012695 ENOG4105DIQ Transcriptional regulator MC60_012740 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) MC60_012745 ENOG41062JF Transcriptional regulator MC60_012750 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MC60_012755 ENOG4105CPQ Dehydrogenase MC60_012760 ENOG4105MPD Cytochrome MC60_012765 ENOG4105BZU Histidine kinase MC60_012770 ENOG4105C4R Atp-dependent dna helicase MC60_012775 ENOG4105C9B Cysteine desulfurase MC60_012780 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) MC60_012785 ENOG4105CUZ uba thif-type nad fad binding protein MC60_012830 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) MC60_012835 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) MC60_012840 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit MC60_012845 ENOG4105FCD Major Facilitator MC60_012850 ENOG4105DY9 regulatoR MC60_012855 ENOG4108HRK Histidine kinase MC60_012865 ENOG4105BZU Histidine kinase MC60_012870 ENOG4107ZHV Transcriptional regulator MC60_012875 ENOG4108GWT fimbrillin MatB MC60_012880 ENOG4108NN8 Fimbrial protein MC60_012885 ENOG4108N3D putative enzyme MC60_012900 ENOG4108NIW Leucine export protein LeuE MC60_012905 ENOG4105EU0 Major facilitator Superfamily MC60_012910 ENOG4105CBX hi0933 family MC60_012915 ENOG41090A1 ferritin MC60_012920 ENOG4105BZU Histidine kinase MC60_012925 ENOG4105RKW reductase (By MC60_012935 ENOG4108M6U Universal stress protein A MC60_012965 ENOG4105EMK carboxylate amino acid amine transporter MC60_012975 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) MC60_012980 ENOG4105DKP glycosyl transferase, family 9 MC60_012995 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) MC60_013000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MC60_013005 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase MC60_013010 ENOG4105EQK -acetyltransferase MC60_013015 ENOG4108EUD Lysophospholipase MC60_013020 ENOG4105DQF Hydrolase MC60_013050 ENOG4105Y7M Transcriptional regulator, TetR family MC60_013055 ENOG410624X efflux transporter, rnd family, mfp subunit MC60_013060 ENOG4105BZS acriflavin resistance protein MC60_013065 ENOG4105BZU Histidine kinase MC60_013070 ENOG4105DC8 reductase MC60_013080 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MC60_013085 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MC60_013095 ENOG4105C08 Histidine kinase MC60_013100 ENOG4105EEX Two component transcriptional regulator (Winged helix family MC60_013105 ENOG4105C2C drug resistance transporter, Bcr CflA MC60_013120 ENOG4105JKW Valine--pyruvate aminotransferase MC60_013125 ENOG4108ZNX Heat shock protein MC60_013130 ENOG4108ZNX Heat shock protein MC60_013135 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein MC60_013140 ENOG4108R6W Transcriptional regulator, ARAC family MC60_013145 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC60_013150 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MC60_013155 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MC60_013160 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) MC60_013165 ENOG4105EAB amino acid AbC transporter MC60_013170 ENOG4105E5Q amino acid AbC transporter MC60_013175 ENOG4105CDA abc transporter atp-binding protein MC60_013180 ENOG4105VG0 50S ribosomal protein l34 MC60_013185 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) MC60_013190 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) MC60_013195 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MC60_013200 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) MC60_013205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC60_013260 ENOG4105CAF HipA N-terminal domain protein MC60_013265 ENOG4105S6R Iron-hydroxamate transporter permease subunit MC60_013270 ENOG4105J76 Periplasmic binding protein MC60_013275 ENOG4105E0A ABC, transporter MC60_013280 ENOG4105IBP Cyclic peptide transporter MC60_013285 ENOG4105E0K tonB-dependent siderophore receptor MC60_013290 ENOG4105QTB Flavodoxin MC60_013295 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) MC60_013300 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) MC60_013305 ENOG4107QJE Chromosome Partitioning Protein MC60_013310 ENOG4105FA0 parb-like partition protein MC60_013320 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) MC60_013325 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MC60_013330 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MC60_013335 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MC60_013340 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) MC60_013345 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) MC60_013350 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) MC60_013355 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) MC60_013360 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) MC60_013365 ENOG4105CT7 inner membrane cred family protein MC60_013375 ENOG4105EB3 Histidine kinase MC60_013380 ENOG4105E3W Two component transcriptional regulator (Winged helix family MC60_013385 ENOG410804X Transcriptional regulator MC60_013390 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MC60_013395 ENOG4105VJY transcriptional regulator MC60_013415 ENOG4109015 Biopolymer transport protein exbD tolR MC60_013420 ENOG410822N TonB family MC60_013455 ENOG4105DZC cytosine deaminase MC60_013460 ENOG4105WMR Protein CrcB homolog MC60_013470 ENOG4105JC1 sterol-binding domain protein MC60_013475 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) MC60_013480 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) MC60_013485 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) MC60_013490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) MC60_013495 ENOG4105F8V Hydrolase, tatD family MC60_013500 ENOG4105D52 delta-aminolevulinic acid dehydratase MC60_013505 ENOG4105DGW oligopeptidase A MC60_013510 ENOG4105BZU Histidine kinase MC60_013515 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) MC60_013525 ENOG4105C9X ppx gppa phosphatase MC60_013530 ENOG4105C1J atp-dependent rna helicase MC60_013535 ENOG4105K63 Thioredoxin MC60_013540 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) MC60_013550 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) MC60_013555 ENOG4107QK7 reductase MC60_013560 ENOG4105W0Z cytoplasmic protein MC60_013575 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) MC60_013590 ENOG4108IV0 ABC, transporter MC60_013595 ENOG4105C0Z ABC transporter MC60_013600 ENOG4105CF8 branched-chain amino acid ABC transporter, permease MC60_013605 ENOG4105C32 Amino acid ABC transporter (Permease) MC60_013610 ENOG4105CP9 extracellular ligand-binding receptor MC60_013615 ENOG4105ETE Transcriptional regulator (LacI family MC60_013620 ENOG4108JUA Transcriptional regulator MC60_013625 ENOG4105CNW domain protein MC60_013630 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase MC60_013640 ENOG4105HEE Binding Domain protein MC60_013650 ENOG4105C0F tryptophanase EC 4.1.99.1 MC60_013655 ENOG4105CIC tryptophan-specific transport protein MC60_013660 ENOG4105CIC tryptophan-specific transport protein MC60_013685 ENOG4105C38 Glycyl-tRNA synthetase beta subunit MC60_013690 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit MC60_013695 ENOG4108R3E Dna-3-methyladenine glycosylase i MC60_013700 ENOG4105D3W isochorismatase MC60_013710 ENOG4108ZG0 Ompa motb domain protein MC60_013730 ENOG4105M4H endoribonuclease L-psp MC60_013735 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) MC60_013750 ENOG4105E0F Histidine kinase MC60_013755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC60_013760 ENOG4105CHU acetyl-coa acetyltransferase MC60_013765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MC60_013770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MC60_013775 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) MC60_013780 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein MC60_013785 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) MC60_013790 ENOG4108RR8 protoporphyrinogen oxidase MC60_013820 ENOG4105CD5 CoA-binding domain protein MC60_013830 ENOG4105EMY transcriptional regulator MC60_013835 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MC60_013840 ENOG4107QP8 phosphohexose isomerase MC60_013850 ENOG4105D64 Mechanosensitive ion channel MC60_013860 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) MC60_013865 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MC60_013870 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase MC60_013875 ENOG4105W5Q DNA repair protein (RadC MC60_013880 ENOG4105KDC 50s ribosomal protein l28 MC60_013885 ENOG4105W0E 50S ribosomal protein L33 MC60_013895 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MC60_013900 ENOG4108MJ5 VirK protein MC60_013905 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) MC60_013910 ENOG4105M5K heptosyltransferase MC60_013915 ENOG4106WTF Glycosyl transferase, family 2 MC60_013920 ENOG4105XA0 heptosyltransferase ii MC60_013925 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase MC60_013935 ENOG4105DSJ YicC domain protein MC60_013940 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) MC60_013945 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) MC60_013965 ENOG4105PC1 Conserved Protein MC60_013975 ENOG4105E27 serine threonine protein kinase MC60_013980 ENOG4108Z33 Thiol disulfide Interchange Protein MC60_013985 ENOG4107RH7 Nicotinate phosphoribosyltransferase MC60_013990 ENOG4108RWI nicotinamidase MC60_014000 ENOG4105EWC Purine nucleoside phosphorylase MC60_014005 ENOG4106HNH Acyl-transferase MC60_014010 ENOG4106HNH Acyl-transferase MC60_014015 ENOG4105C0P Mg chelatase subunit ChlI MC60_014030 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit MC60_014035 ENOG4105CM2 brancheD-chain amino acid aminotransferase MC60_014040 ENOG4105C01 Dihydroxy-acid dehydratase MC60_014045 ENOG4105C7B Threonine dehydratase MC60_014050 ENOG4105UYK outer membrane protein a MC60_014060 ENOG4105XEA Tetr family transcriptional regulator MC60_014065 ENOG4105C25 Primosomal protein n' MC60_014070 ENOG4105VFB Binds the 23S rRNA (By similarity) MC60_014075 ENOG4105CGD Nad-dependent epimerase dehydratase MC60_014080 ENOG4105C6K Malic enzyme MC60_014090 ENOG4105JJR Histidine kinase MC60_014095 ENOG4107EXC regulatoR MC60_014100 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) MC60_014115 ENOG4107R28 alpha amylase, catalytic region MC60_014130 ENOG4105R8A Heat shock protein MC60_014135 ENOG4105C5I Dehydrogenase MC60_014140 ENOG4108RH0 Crea protein MC60_014155 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters MC60_014160 ENOG4105CFQ glutamine synthetase MC60_014165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MC60_014175 ENOG4108HM4 ABC transporter MC60_014180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC60_014185 ENOG4105F38 ABC transporter, permease MC60_014190 ENOG4105D38 putrescine abc transporter MC60_014195 ENOG4108RPX mosc domain containing protein MC60_014210 ENOG4108VUY thioesterase Superfamily protein MC60_014215 ENOG4105C9U ATP-dependent DNA helicase RecQ MC60_014220 ENOG4105N7H Cytochrome MC60_014225 ENOG4105CNG UPF0061 protein MC60_014235 ENOG4105EX9 Membrane MC60_014240 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) MC60_014245 ENOG4105CJW magnesium transporter MC60_014250 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MC60_014255 ENOG4107V9H nitrite transporter MC60_014260 ENOG4105WZK nitrite reductase NADPH small subunit MC60_014265 ENOG4107QZF nitrite reductase NADPH large subunit MC60_014270 ENOG4107QWP ABC-2 type transporter MC60_014275 ENOG4107QWP ABC-2 type transporter MC60_014280 ENOG4105CJ1 ABC, transporter MC60_014285 ENOG4105D0S secretion protein (HlyD MC60_014300 ENOG4105C57 major facilitator superfamily MC60_014305 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) MC60_014310 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) MC60_014320 ENOG4105C75 arginyL-tRNA synthetase MC60_014330 ENOG4105K6V RNA polymerase MC60_014335 ENOG4108NIX Factor ChrR MC60_014340 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MC60_014345 ENOG4105CPC Aldo Keto reductase MC60_014350 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) MC60_014355 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) MC60_014360 ENOG4105F0Z galactose-1-phosphate uridylyltransferase MC60_014365 ENOG4105CMR udp-glucose 4-epimerase MC60_014370 ENOG41060NJ transcriptional regulator MC60_014375 ENOG4105CNT hydrolase family 2 MC60_014390 ENOG4107SDZ Galactoside transport system permease protein mglC MC60_014395 ENOG4105C8Q Methyl-accepting chemotaxis MC60_014410 ENOG4105C5B carbamate kinase MC60_014415 ENOG4105DBV ornithine carbamoyltransferase MC60_014420 ENOG4105CSX c4-dicarboxylate anaerobic carrier MC60_014425 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) MC60_014430 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) MC60_014435 ENOG4105CXT aspartate transcarbamylase MC60_014460 ENOG4105C8Q Methyl-accepting chemotaxis MC60_014470 ENOG4105QNF Outer membrane lipoprotein MC60_014475 ENOG4105CF7 AraC family transcriptional regulator MC60_014480 ENOG4108I6A alcohol dehydrogenase MC60_014485 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MC60_014490 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MC60_014495 ENOG4105WWK YheO domain protein MC60_014500 ENOG4105CEM UPF0597 protein MC60_014505 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane MC60_014510 ENOG4105C34 Pseudouridine synthase MC60_014515 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase MC60_014520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MC60_014525 ENOG4107T8T UPF0173 metal-dependent hydrolase MC60_014530 ENOG4105CU9 asparagine synthetase A MC60_014535 ENOG4108VVK transcriptional Regulator, AsnC MC60_014545 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC60_014550 ENOG410642E Short chain dehydrogenase MC60_014565 ENOG4107WP9 Histidine kinase MC60_014575 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_014580 ENOG4108UQ5 membrane protein YcdZ MC60_014590 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) MC60_014595 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) MC60_014610 ENOG4105XJC Two component transcriptional regulator (Winged helix family MC60_014615 ENOG4105IFJ Histidine kinase MC60_014625 ENOG4107QY8 reductase MC60_014630 ENOG4105CUW cytochrome C-TYPE protein MC60_014635 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MC60_014645 ENOG4107ZYR domain protein MC60_014650 ENOG4105D4A Cell wall formation (By similarity) MC60_014655 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase MC60_014660 ENOG4105CS9 pantothenic acid kinase MC60_014675 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MC60_014685 ENOG4105PM1 preprotein translocase subunit SecE MC60_014690 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) MC60_014695 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) MC60_014700 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) MC60_014705 ENOG4108VZM 50s ribosomal protein L10 MC60_014710 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MC60_014715 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MC60_014720 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MC60_014725 ENOG4105WWK YheO domain protein MC60_014730 ENOG4105KME endoribonuclease L-psp MC60_014735 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) MC60_014745 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) MC60_014750 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) MC60_014755 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) MC60_014760 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) MC60_014765 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MC60_014770 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase MC60_014805 ENOG4105C7N Xanthine uracil vitamin C permease MC60_014810 ENOG4105CMT Dihydroxyacetone kinase MC60_014815 ENOG4108UTZ Dihydroxyacetone kinase MC60_014830 ENOG4105ETT transcriptional Regulator, LysR family MC60_014835 ENOG4105DWY Agmatine deiminase MC60_014850 ENOG4105DWY Agmatine deiminase MC60_014860 ENOG4105IPI Membrane MC60_014890 ENOG4105CH6 catalase MC60_014895 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MC60_014915 ENOG4105BZU Histidine kinase MC60_014925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC60_014935 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component MC60_014960 ENOG4105CWB LysR family transcriptional Regulator MC60_014970 ENOG4105C2I pirin domain protein MC60_014975 ENOG4108VBZ doxx family MC60_014980 ENOG4105DSY exodeoxyribonuclease V, gamma MC60_014985 ENOG4107QKA exodeoxyribonuclease V beta MC60_014990 ENOG4107QYX exodeoxyribonuclease v alpha MC60_015000 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase MC60_015015 ENOG4108YZA Nitrogen regulatory protein pii MC60_015020 ENOG4105BZU Histidine kinase MC60_015030 ENOG4108NVR Methyl-accepting chemotaxis MC60_015040 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC60_015045 ENOG4105E0F Histidine kinase MC60_015050 ENOG4105VEQ Cold shock protein MC60_015070 ENOG4108UUM single-stranded DNA-binding protein MC60_015075 ENOG41086KC Transcriptional regulator MC60_015080 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MC60_015085 ENOG4105EIF outer membrane protein W MC60_015105 ENOG4105SYT Methylenetetrahydrofolate reductase MC60_015115 ENOG4105DKK Benzoate MC60_015120 ENOG4108JCI Transcriptional regulator MC60_015150 ENOG41090HJ UPF0265 protein MC60_015160 ENOG4105N42 UPF0307 protein MC60_015165 ENOG4105CMS peptidase U62, modulator of DNA gyrase MC60_015170 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MC60_015175 ENOG4105VFK BolA family MC60_015185 ENOG4105E3I toluene tolerance MC60_015190 ENOG4107PE3 Mammalian cell entry related domain protein MC60_015195 ENOG4105CY3 ABC transporter, permease MC60_015200 ENOG4105DHJ ABC, transporter MC60_015205 ENOG4105C2X Arabinose 5-phosphate isomerase MC60_015210 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase MC60_015220 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA MC60_015225 ENOG4108IUZ ABC transporter MC60_015230 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC60_015235 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA MC60_015240 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN MC60_015245 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) MC60_015250 ENOG41080Z8 PHOSPHOCARRIER protein MC60_015270 ENOG41069H0 dihydroorotase EC 3.5.2.3 MC60_015300 ENOG4105C0H protease MC60_015305 ENOG4105C0H protease MC60_015315 ENOG4105D6Z AFG1 family ATPase MC60_015320 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) MC60_015325 ENOG4108UJD 30S ribosomal protein S9 MC60_015330 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) MC60_015335 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) MC60_015340 ENOG4105EIX cytochrome c1 MC60_015345 ENOG4107MKT Stringent starvation protein a MC60_015350 ENOG4105KB2 stringent starvation protein b MC60_015355 ENOG4105W4M Transport-associated protein MC60_015360 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) MC60_015365 ENOG41082RQ UPF0102 protein MC60_015370 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) MC60_015375 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) MC60_015390 ENOG4105DD5 Flagellar motor switch protein MC60_015395 ENOG4105CN7 Flagellar biosynthetic protein FliP MC60_015400 ENOG4105VS8 Flagellar biosynthetic protein fliq MC60_015405 ENOG4105D19 Role in flagellar biosynthesis (By similarity) MC60_015410 ENOG4105D00 flagellar biosynthetic protein flhB MC60_015420 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC60_015425 ENOG4105VQ0 flagellar hook-basal body complex protein fliE MC60_015430 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) MC60_015435 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MC60_015445 ENOG4108JIR Flagellum-specific ATP synthase MC60_015465 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA MC60_015470 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) MC60_015475 ENOG4108ZC9 flagellar basal-body rod protein flgc MC60_015480 ENOG4105W00 Flagellar hook capping protein MC60_015485 ENOG4105BZE flagellar hook protein, FlgE MC60_015490 ENOG4108KPB Flagellar basal-body rod protein FlgF MC60_015495 ENOG4105CGA flagellar basal-body rod protein FlgG MC60_015500 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) MC60_015505 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) MC60_015515 ENOG4105E1Q flagellar hook-associated protein MC60_015520 ENOG4105DTJ flagellar hook-associated protein MC60_015535 ENOG4105I03 Flagellin MC60_015540 ENOG410804A Flagellar hook-associated 2 domain-containing protein MC60_015545 ENOG4105MQ3 flagellar protein FliS MC60_015570 ENOG4107RD7 Flagellar Motor Protein, MotA MC60_015575 ENOG4105ER2 Ompa motb domain protein MC60_015585 ENOG4105E9H Lytic Murein transglycosylase MC60_015595 ENOG4108V6E Cell division protein mraZ MC60_015600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) MC60_015605 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) MC60_015610 ENOG4105CJN penicillin-binding protein MC60_015615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MC60_015620 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) MC60_015625 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) MC60_015630 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MC60_015635 ENOG4105CNI cell division protein FtsW MC60_015640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) MC60_015645 ENOG4105DFU Cell wall formation (By similarity) MC60_015650 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) MC60_015655 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) MC60_015660 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) MC60_015665 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) MC60_015675 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving MC60_015685 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MC60_015690 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) MC60_015695 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) MC60_015710 ENOG4105D7Q type ii secretion system MC60_015715 ENOG4107QHF type ii secretion system protein e MC60_015725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase MC60_015745 ENOG41073TP transcriptional regulator MC60_015750 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) MC60_015755 ENOG4107QSN dihydrolipoamide acetyltransferase MC60_015760 ENOG4107QN2 dihydrolipoyl dehydrogenase MC60_015770 ENOG4108N3W hemolysin secretion protein MC60_015775 ENOG4108N3W hemolysin secretion protein MC60_015780 ENOG4105D78 K07001 NTE family protein MC60_015785 ENOG4107QIJ Aconitate hydratase 2 MC60_015790 ENOG4105BZU Histidine kinase MC60_015800 ENOG4105E82 cytochrome subunit of dehydrogenase MC60_015810 ENOG4105CKI cobalamin synthesis protein MC60_015815 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC60_015825 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MC60_015830 ENOG4107ZVW dihydroneopterin aldolase MC60_015835 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) MC60_015880 ENOG4107AQZ Membrane MC60_015890 ENOG4108UW5 maltose o-acetyltransferase MC60_015895 ENOG4105CG3 alpha amylase, catalytic region MC60_015900 ENOG4105C5Y PTS System MC60_015905 ENOG4105D4X repressor MC60_015915 ENOG4105EIP mannose-6-phosphate isomerase MC60_015920 ENOG4105CK1 PTS System MC60_015925 ENOG4105VZJ PTS System MC60_015930 ENOG4105CK1 PTS System MC60_015935 ENOG4105CS2 ec 3.2.1.21 MC60_015940 ENOG4105VCP PTS System MC60_015945 ENOG4105DKQ ROK family MC60_015955 ENOG4105DDV Transcriptional regulator (LacI family MC60_015965 ENOG4105HDK L-asparaginase MC60_015980 ENOG4108Z5K methylglyoxal synthase MC60_015985 ENOG4108UQY Iron-storage protein MC60_016000 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) MC60_016005 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) MC60_016015 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) MC60_016045 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MC60_016050 ENOG4105C26 Dehydrogenase MC60_016055 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component MC60_016060 ENOG4105D81 ABC transporter, permease MC60_016065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC60_016070 ENOG4107TYH extracellular solute-binding protein family 1 MC60_016075 ENOG4108M0I Transcriptional regulator MC60_016080 ENOG4105DFD Na H antiporter MC60_016120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) MC60_016125 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) MC60_016130 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) MC60_016135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MC60_016145 ENOG4107VXZ Hydrolase MC60_016150 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) MC60_016155 ENOG4105F1S paraquat-inducible protein a MC60_016160 ENOG4105DY2 Paraquat-inducible protein b MC60_016165 ENOG4108Q2G (LipO)protein MC60_016170 ENOG4105UYK outer membrane protein a MC60_016190 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) MC60_016195 ENOG4105CEN a g-specific adenine glycosylase MC60_016210 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate MC60_016215 ENOG4105CJ3 phosphate transporter MC60_016220 ENOG4107IX6 phosphate transport regulator MC60_016225 ENOG4105I7R Adenylate cyclase MC60_016230 ENOG4108XTF Outer Membrane Lipoprotein MC60_016235 ENOG4108R6G acetyltransferase MC60_016250 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase MC60_016255 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) MC60_016260 ENOG4105VEJ Heat shock protein MC60_016270 ENOG4105GVR general secretion pathway protein D MC60_016275 ENOG4107QHF type ii secretion system protein e MC60_016280 ENOG4105D7Q type ii secretion system MC60_016285 ENOG4108VAU general secretion pathway protein G MC60_016330 ENOG4108UDW Transcriptional regulator, luxr family MC60_016335 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MC60_016340 ENOG4105JQN Transcriptional regulator MC60_016345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MC60_016350 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 MC60_016355 ENOG4107RK2 ADP-ribose diphosphatase NudE MC60_016360 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase MC60_016365 ENOG4105C44 Serine transporter MC60_016370 ENOG4108Z7R Chaperone CsaA MC60_016380 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) MC60_016385 ENOG4105C28 cystathionine MC60_016390 ENOG4105CFH Aspartokinase MC60_016395 ENOG41067MG lrgb family MC60_016405 ENOG4105CMU LysR family (Transcriptional regulator MC60_016440 ENOG4108Z66 YbaK ebsC protein MC60_016445 ENOG4105BZU Histidine kinase MC60_016450 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) MC60_016460 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MC60_016465 ENOG4105CAS nag kinase MC60_016475 ENOG4105CDH Citrulline--aspartate ligase MC60_016480 ENOG4105CH7 arginosuccinase MC60_016485 ENOG4107NQ8 LysR family Transcriptional regulator MC60_016510 ENOG4108UW5 maltose o-acetyltransferase MC60_016515 ENOG4107PU6 Membrane MC60_016520 ENOG4105CT1 (ABC) transporter MC60_016525 ENOG4105CDA abc transporter atp-binding protein MC60_016530 ENOG4105E5Q amino acid AbC transporter MC60_016535 ENOG4105DRP amino acid AbC transporter MC60_016540 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) MC60_016560 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MC60_016565 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) MC60_016575 ENOG4105C8Q Methyl-accepting chemotaxis MC60_016580 ENOG4105EYW Ion transport protein MC60_016585 ENOG4106MWK domain protein MC60_016590 ENOG4105E09 nadh pyrophosphatase MC60_016595 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) MC60_016600 ENOG4105DKQ ROK family MC60_016605 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MC60_016610 ENOG4105BZA Phosphoglycerate kinase MC60_016615 ENOG4105D2N Aldolase MC60_016620 ENOG4105CJP fad dependent oxidoreductase MC60_016630 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) MC60_016635 ENOG4105VF7 tolerance protein MC60_016650 ENOG4105DUM transcriptional regulator, lysR family MC60_016660 ENOG4105Y75 tpr repeat protein MC60_016670 ENOG4108IYU L-aspartate oxidase MC60_016675 ENOG4105EMN RNA polymerase sigma factor MC60_016680 ENOG41069PW sigma-e factor negative regulatory protein MC60_016695 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) MC60_016700 ENOG4105C3F Signal peptidase i MC60_016705 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) MC60_016715 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) MC60_016720 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) MC60_016725 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase MC60_016730 ENOG4108W15 Protein of unknown function (DUF1456) MC60_016735 ENOG4105BZU Histidine kinase MC60_016740 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MC60_016745 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MC60_016750 ENOG4105DXN mazG family MC60_016755 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) MC60_016760 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) MC60_016765 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) MC60_016770 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) MC60_016775 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) MC60_016780 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) MC60_016785 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) MC60_016790 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) MC60_016795 ENOG4108UM1 dedA family MC60_016800 ENOG4108K5P (LipO)protein MC60_016810 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MC60_016815 ENOG4105VCC 30S ribosomal protein S21 MC60_016820 ENOG4105KTH gatB Yqey MC60_016825 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MC60_016830 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC60_016840 ENOG4107R3N Filamentation induced by cAMP protein fic MC60_016925 ENOG4105C12 Phosphoribosylglycinamide synthetase MC60_016930 ENOG4105DC1 bifunctional purine biosynthesis protein purh MC60_016950 ENOG4105CSA Coproporphyrinogen iii oxidase MC60_016955 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MC60_016965 ENOG4105D9R oxidoreductase MC60_016975 ENOG4105G5H Membrane MC60_016980 ENOG4107QX8 SPFH domain, Band 7 family protein MC60_016985 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MC60_016990 ENOG4105C11 sulfate adenylyltransferase), subunit 2 MC60_016995 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) MC60_017005 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) MC60_017025 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor MC60_017045 ENOG4105C19 ABC transporter MC60_017060 ENOG4108UUE Transcriptional regulator MC60_017075 ENOG4105F0N pyrophosphate phospho-hydrolase MC60_017080 ENOG4105DFU Cell wall formation (By similarity) MC60_017085 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase MC60_017090 ENOG410630P Transcriptional regulator MC60_017095 ENOG4108UGV hypoxanthine phosphoribosyltransferase MC60_017100 ENOG4105DA5 (ABC) transporter MC60_017105 ENOG4105E3A (ABC) transporter MC60_017115 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) MC60_017120 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) MC60_017125 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MC60_017130 ENOG4105DJ0 Poly(A) Polymerase MC60_017135 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) MC60_017140 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters MC60_017145 ENOG4105PW4 Sugar fermentation stimulation protein homolog MC60_017155 ENOG4105CQ7 ATP-dependent helicase MC60_017160 ENOG4105BZ4 penicillin-binding protein MC60_017165 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MC60_017170 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) MC60_017175 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) MC60_017180 ENOG4105EGI Transcriptional regulator MC60_017190 ENOG41076MN Phosphoesterase, PA-phosphatase related MC60_017205 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MC60_017210 ENOG4105CMQ Chloride channel MC60_017220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA MC60_017250 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) MC60_017255 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) MC60_017265 ENOG4107V40 secretion protein, HlyD family MC60_017295 ENOG4105I93 response regulator MC60_017300 ENOG4105DUX Transporter MC60_017305 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MC60_017310 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein MC60_017315 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase MC60_017320 ENOG4105K9H YciI-like protein MC60_017325 ENOG4107835 probably involved in intracellular septation (By similarity) MC60_017330 ENOG4105DY8 decarboxylase MC60_017335 ENOG4108UT2 hemolysin iii MC60_017340 ENOG4105D0C transport protein MC60_017370 ENOG4105EV4 Multidrug resistance protein mdtH MC60_017380 ENOG4105D4Y metalloprotease MC60_017390 ENOG4105D9U N-acetyltransferase MC60_017400 ENOG4105XEP YhcH YjgK YiaL family protein MC60_017410 ENOG4105CUY Mechanosensitive ion channel MC60_017415 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MC60_017420 ENOG4105CK7 Sodium proline symporter MC60_017435 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) MC60_017455 ENOG4105D6S protein involved in catabolism of external DNA MC60_017465 ENOG4105C5H ABC transporter MC60_017470 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC60_017480 ENOG4107R88 Chemotaxis protein (CheV) MC60_017485 ENOG4108UJV acyl-CoA thioesterase i MC60_017490 ENOG4108I0Y (ABC) transporter MC60_017495 ENOG4105CV6 ABC transporter, permease MC60_017500 ENOG4105ECP epimerase MC60_017505 ENOG4107XTP (EAL) domain protein MC60_017510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC60_017515 ENOG4105IIU Aminopeptidase MC60_017520 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) MC60_017525 ENOG41090ED Protein with unknown function (DUF469) MC60_017530 ENOG4105CSV Glutaminase MC60_017535 ENOG4107RM6 sulfurtransferase MC60_017540 ENOG4105E3R (LipO)protein MC60_017545 ENOG4108W78 Pfam:DUF1017 MC60_017550 ENOG4108MDC (LipO)protein MC60_017570 ENOG4105SUV lipoprotein YgdR MC60_017575 ENOG4105BZ1 (ABC) transporter MC60_017620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MC60_017640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC60_017675 ENOG4105NI8 Cytosine-specific methyltransferase MC60_017685 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) MC60_017690 ENOG4105BZU Histidine kinase MC60_017710 ENOG4105VYA Uncharacterized conserved protein (DUF2132) MC60_017715 ENOG4105DJ4 phosphatidylserine decarboxylase MC60_017720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) MC60_017725 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) MC60_017765 ENOG4105VEQ Cold shock protein MC60_017775 ENOG4105C8Q Methyl-accepting chemotaxis MC60_017780 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MC60_017785 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MC60_017790 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MC60_017840 ENOG4109015 Biopolymer transport protein exbD tolR MC60_017865 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component MC60_017870 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component MC60_017885 ENOG4108JQ7 (ABC) transporter MC60_017895 ENOG4105CIN aminoacyl-histidine dipeptidase MC60_017905 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) MC60_017910 ENOG4105V1F Fermentation respiration switch protein MC60_017915 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) MC60_017925 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) MC60_017955 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MC60_017970 ENOG4105DG7 nitrate ABC transporter MC60_017975 ENOG4105D7T ABC transporter MC60_017980 ENOG4107QZF nitrite reductase NADPH large subunit MC60_017985 ENOG4107QZF nitrite reductase NADPH large subunit MC60_017990 ENOG4105DD7 kinase (PfkB family MC60_017995 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) MC60_018015 ENOG4108RIR Molybdenum cofactor biosynthesis protein MC60_018025 ENOG4105DWK Membrane MC60_018030 ENOG4107XM3 UPF0442 protein MC60_018040 ENOG4108IJ7 Glycine betaine MC60_018045 ENOG4108HQS Glycine betaine MC60_018050 ENOG4105GIJ Glycine betaine MC60_018055 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) MC60_018060 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) MC60_018065 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MC60_018070 ENOG4107TIF Phenazine biosynthesis protein, PhzF family MC60_018075 ENOG4105CRK lysyL-tRNA synthetase MC60_018085 ENOG4105C8Q Methyl-accepting chemotaxis MC60_018090 ENOG4105D6U Sodium Glutamate Symporter MC60_018095 ENOG4105HDK L-asparaginase MC60_018100 ENOG4105VUT cytoplasmic protein MC60_018120 ENOG4105D07 Signal peptide peptidase, SppA MC60_018125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MC60_018130 ENOG41069NU Nitroreductase MC60_018135 ENOG4105C8Q Methyl-accepting chemotaxis MC60_018140 ENOG4108UW5 maltose o-acetyltransferase MC60_018145 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) MC60_018150 ENOG4105CIS alcohol dehydrogenase MC60_018155 ENOG4105HEI LysR family (Transcriptional regulator MC60_018160 ENOG4105CI1 PTS System MC60_018165 ENOG4108IA2 Sodium pantothenate symporter MC60_018170 ENOG4105RG0 Membrane MC60_018175 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MC60_018180 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein MC60_018185 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) MC60_018190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MC60_018195 ENOG4105BZU Histidine kinase MC60_018205 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) MC60_018220 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) MC60_018230 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) MC60_018235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) MC60_018250 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) MC60_018255 ENOG4107YIM Involved in the transcription termination process (By similarity) MC60_018260 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) MC60_018265 ENOG4108ZAI phosphatidylglycerophosphatase a MC60_018270 ENOG4108JQ6 ABC transporter MC60_018280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC60_018285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC60_018290 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) MC60_018295 ENOG4105CTB Polyprenyl synthetase MC60_018300 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) MC60_018305 ENOG4105E14 MotA TolQ exbB proton channel MC60_018310 ENOG4107XSU flagellar motor protein motb MC60_018315 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) MC60_018325 ENOG4105HBR Rna-binding protein MC60_018330 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) MC60_018335 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) MC60_018340 ENOG4105EEI dihydropteroate synthase MC60_018345 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) MC60_018350 ENOG4105CP7 Triose-phosphate isomerase MC60_018370 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) MC60_018375 ENOG4105CHV Transcription elongation factor NusA MC60_018380 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) MC60_018385 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) MC60_018390 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) MC60_018395 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) MC60_018400 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) MC60_018405 ENOG4105E5W Transporter MC60_018410 ENOG41090EX DsrE family MC60_018415 ENOG4105WAY exported protein MC60_018420 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding MC60_018425 ENOG4105CFP Peptidase U32 MC60_018430 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MC60_018450 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) MC60_018455 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC60_018460 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) MC60_018470 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) MC60_018490 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) MC60_018525 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) MC60_018545 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) MC60_018550 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) MC60_018555 ENOG4108Z43 UPF0250 protein MC60_018560 ENOG4105DZ1 carboxypeptidase MC60_018565 ENOG4105K6T rare lipoprotein A MC60_018570 ENOG4105CVE Lytic murein transglycosylase MC60_018575 ENOG4105CNI cell division protein FtsW MC60_018580 ENOG4105CJN penicillin-binding protein MC60_018585 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) MC60_018590 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) MC60_018595 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) MC60_018610 ENOG4105C8T Leucyl-tRNA synthetase MC60_018615 ENOG4107PAI alpha helical protein MC60_018620 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) MC60_018625 ENOG4108JU5 Magnesium and cobalt efflux protein MC60_018630 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) MC60_018635 ENOG4105C9A Phoh family MC60_018640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MC60_018645 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family MC60_018650 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) MC60_018665 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 MC60_018670 ENOG4105BZU Histidine kinase MC60_018680 ENOG4108KHX Diguanylate cyclase MC60_018690 ENOG4105C5I Dehydrogenase MC60_018710 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) MC60_018715 ENOG4108UMI ABC transporter, permease MC60_018720 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) MC60_018730 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC60_018735 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) MC60_018740 ENOG4105DHQ Histidine kinase MC60_018745 ENOG4105XJC Two component transcriptional regulator (Winged helix family MC60_018755 ENOG4108IXY short-chain dehydrogenase reductase MC60_018775 ENOG4106371 Methyltransferase MC60_018780 ENOG4105T0Z Conserved Protein MC60_018795 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) MC60_018800 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) MC60_018805 ENOG4105E33 succinate dehydrogenase MC60_018815 ENOG4105C8Q Methyl-accepting chemotaxis MC60_018820 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MC60_018825 ENOG4105EGS Mechanosensitive ion channel MC60_018835 ENOG4105DR5 peptidase MC60_018850 ENOG4105EJC lysr family transcriptional regulator MC60_018865 ENOG4105C5Q Transcriptional regulator MC60_018870 ENOG4108JQC penicillin-binding protein 1A MC60_018895 ENOG4105E4G Type IV pilus MC60_018900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) MC60_018905 ENOG4105D49 3-dehydroquinate synthase MC60_018915 ENOG4105DFE Dna adenine methylase MC60_018920 ENOG4105DJV ribulose-phosphate 3-epimerase MC60_018925 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MC60_018930 ENOG4105C31 Tryptophanyl-tRNA synthetase MC60_018945 ENOG4105C8Y Acetylornithine aminotransferase MC60_018950 ENOG4105F4X arginine MC60_018955 ENOG4105C26 Dehydrogenase MC60_018970 ENOG4107VXZ Hydrolase MC60_018990 ENOG41060QA UPF0267 protein MC60_018995 ENOG4107QWE )-transporter MC60_019040 ENOG4105C3G gtp-binding protein MC60_019045 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) MC60_019050 ENOG4105C5T Phosphoribosyl pyrophosphate synthase MC60_019060 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) MC60_019065 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) MC60_019070 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) MC60_019075 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) MC60_019080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MC60_019090 ENOG41063JG Transcriptional regulator MC60_019095 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase MC60_019100 ENOG4105CK2 sodium dicarboxylate symporter MC60_019105 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) MC60_019110 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) MC60_019125 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MC60_019130 ENOG4105BZG amino acid carrier protein MC60_019135 ENOG41066YJ Beta-lactamase MC60_019145 ENOG4105G2Y Transcriptional regulator MC60_019150 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) MC60_019155 ENOG4108UJU UPF0301 protein MC60_019160 ENOG4105D7Z glutathione synthase MC60_019165 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) MC60_019175 ENOG4105GPY SprT protein MC60_019180 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP MC60_019185 ENOG4105CV1 Transketolase (EC 2.2.1.1) MC60_019210 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) MC60_019215 ENOG4105DR5 peptidase MC60_019220 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MC60_019225 ENOG4107WCA isomerase MC60_019235 ENOG4108V1U phospholipid-binding protein MC60_019240 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MC60_019255 ENOG4105C87 Aminotransferase class I and II MC60_019265 ENOG4105C5Q Transcriptional regulator MC60_019270 ENOG4105UBK short-chain dehydrogenase reductase MC60_019275 ENOG4105ERU peptidase MC60_019280 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) MC60_019285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MC60_019295 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor MC60_019300 ENOG4105E2D ec 3.2.1.52 MC60_019305 ENOG4105RD7 BadF BadG BcrA BcrD MC60_019315 ENOG4108JQ7 (ABC) transporter MC60_019325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC60_019340 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) MC60_019345 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase MC60_019350 ENOG41085FC arsR family transcriptional regulator MC60_019355 ENOG4105D6J arsenicaL-resistance protein MC60_019360 ENOG4105K89 arsenate reductase MC60_019375 ENOG4105VQ0 flagellar hook-basal body complex protein fliE MC60_019380 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) MC60_019385 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MC60_019395 ENOG4108JIR Flagellum-specific ATP synthase MC60_019415 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MC60_019420 ENOG4105DD5 Flagellar motor switch protein MC60_019425 ENOG4105VTB flagellar biosynthesis protein fliO MC60_019430 ENOG4105CN7 Flagellar biosynthetic protein FliP MC60_019435 ENOG4105VS8 Flagellar biosynthetic protein fliq MC60_019440 ENOG4105D19 Role in flagellar biosynthesis (By similarity) MC60_019445 ENOG4105D00 flagellar biosynthetic protein flhB MC60_019450 ENOG4105D7B Flagellar biosynthesis protein flha MC60_019455 ENOG4105FZW flagellar biosynthesis regulator FlhF MC60_019465 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC60_019470 ENOG4108VYJ response regulator receiver protein MC60_019475 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) MC60_019480 ENOG4105CBS Chea signal transduction histidine kinase MC60_019485 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) MC60_019490 ENOG4105E14 MotA TolQ exbB proton channel MC60_019495 ENOG4108SEK ompa motb domain protein MC60_019500 ENOG4107QJE Chromosome Partitioning Protein MC60_019510 ENOG4108V3W Chemotaxis protein, CheW MC60_019525 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) MC60_019530 ENOG41060IM Heme exporter protein MC60_019535 ENOG4105X3C heme exporter protein MC60_019540 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) MC60_019545 ENOG4105DA4 cytochrome c-type biogenesis protein MC60_019550 ENOG4107QX9 Thiol disulfide interChange protein MC60_019555 ENOG4105KWW Biogenesis protein MC60_019565 ENOG410903C (LipO)protein MC60_019570 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MC60_019575 ENOG4105M2J Glutaredoxin MC60_019595 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) MC60_019600 ENOG4107R11 Transcriptional regulator MC60_019625 ENOG4108YYD acetyltransferase MC60_019645 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) MC60_019650 ENOG4108Z1B Cyclase dehydrase MC60_019655 ENOG4105VDB UPF0125 protein MC60_019660 ENOG4105K4T epimerase MC60_019665 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) MC60_019670 ENOG4105C0A alcohol dehydrogenase MC60_019675 ENOG4108I5U Uridine phosphorylase MC60_019680 ENOG4105D3G Pseudouridine synthase MC60_019685 ENOG4105DU0 nucleoside hydrolase MC60_019700 ENOG4105RX8 Protein of unknown function (DUF1523) MC60_019705 ENOG4108NVR Methyl-accepting chemotaxis MC60_019710 ENOG410829K Lysine exporter protein (Lyse ygga) MC60_019720 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) MC60_019735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) MC60_019740 ENOG4105KUZ arsenate reductase MC60_019750 ENOG4105CEE C4-dicarboxylate transporter MC60_019755 ENOG4105CH2 amidohydrolase MC60_019765 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter MC60_019770 ENOG4105C5S asparaginyl-tRNA synthetase MC60_019790 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) MC60_019795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MC60_019800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MC60_019805 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) MC60_019810 ENOG4105D0M Protease HtpX homolog MC60_019815 ENOG4105QVC MOSC domain-containing protein MC60_019815 ENOG4105QVC MOSC domain-containing protein MC60_019825 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) MC60_019830 ENOG4105Z2P Protein of unknown function (DUF465) MC60_019840 ENOG4105UQX Mate efflux family protein MC60_019860 ENOG4105C6T cysteine synthase MC60_019875 ENOG4107Z3H Transcriptional regulator, TetR family MC60_019880 ENOG4107RGH Aldehyde dehydrogenase MC60_019890 ENOG4108QBX (LipO)protein MC60_019895 ENOG4105C5Q Transcriptional regulator MC60_019915 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) MC60_019920 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) MC60_019925 ENOG41081XQ Conserved Protein MC60_019935 ENOG4105C9M aspartyl-trna synthetase MC60_019940 ENOG4105CDY transcriptional regulatory protein MC60_019945 ENOG4105DIJ Phosphoethanolamine transferase MC60_019950 ENOG4105E2R ROK family MC60_019955 ENOG4105CE4 GlcNAc 6-P deacetylase MC60_019960 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MC60_019965 ENOG4105CI1 PTS System MC60_019970 ENOG4105E2D ec 3.2.1.52 MC60_019975 ENOG4105CX6 glutaminyL-tRNA synthetase MC60_019980 ENOG41090R7 Ferric uptake MC60_019990 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) MC60_019995 ENOG4105NNH LexA regulated protein MC60_020005 ENOG4105EV9 Alpha Beta Hydrolase MC60_020010 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) MC60_020015 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 MC60_020025 ENOG41090MY MarR family Transcriptional regulator MC60_020030 ENOG4105CVE Lytic murein transglycosylase MC60_020035 ENOG4108T9J Cdp-alcohol phosphatidyltransferase MC60_020040 ENOG4108VGW abc transporter atp-binding protein MC60_020050 ENOG4105VNH ABC transporter solute-binding protein MC60_020060 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MC60_020070 ENOG4105KQ5 peptidylprolyl cis-trans isomerase MC60_020080 ENOG4105CFU surface antigen MC60_020105 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA MC60_020110 ENOG4105BZU Histidine kinase MC60_020115 ENOG4107SC1 transglycosylase MC60_020120 ENOG41060NJ transcriptional regulator MC60_020130 ENOG4105NAU thioesterase Superfamily protein MC60_020140 ENOG4107NA1 Endonuclease Exonuclease phosphatase MC60_020145 ENOG4105E9H Lytic Murein transglycosylase MC60_020150 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MC60_020155 ENOG4105D1A Methyltransferase MC60_020160 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MC60_020165 ENOG4107RZZ dna polymerase iii epsilon subunit MC60_020175 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase MC60_020180 ENOG4107QPN acyl-Coa dehydrogenase MC60_020185 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) MC60_020190 ENOG4105E7A Glutamine amidotransferase MC60_020200 ENOG4105CHW UPF0052 protein MC60_020210 ENOG4105BZU Histidine kinase MC60_020225 ENOG4105WH1 Two component transcriptional regulator luxr family MC60_020230 ENOG4105BZU Histidine kinase MC60_020235 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MC60_020240 ENOG4108ZNS ferredoxin-type protein NapF MC60_020250 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MC60_020255 ENOG4108BGM Quinol dehydrogenase periplasmic component MC60_020260 ENOG4105GXZ Ferredoxin-type protein NapH MC60_020270 ENOG4105CUW cytochrome C-TYPE protein MC60_020275 ENOG4108RIR Molybdenum cofactor biosynthesis protein MC60_020280 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MC60_020285 ENOG4105M00 molybdopterin converting factor, subunit 1 MC60_020290 ENOG4108ZAF Molybdopterin MC60_020295 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein MC60_020300 ENOG4105E0C molybdate abc transporter MC60_020305 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) MC60_020310 ENOG410832A alpha/beta hydrolase fold MC60_020325 ENOG4105D06 uba thif-type nad fad binding protein MC60_020330 ENOG4105CVM Molybdenum cofactor synthesis domain protein MC60_020335 ENOG4105EUJ GTP cyclohydrolase i MC60_020340 ENOG4105C8Q Methyl-accepting chemotaxis MC60_020355 ENOG4105CC0 LysR family Transcriptional regulator MC60_020360 ENOG4108YYC ycei family MC60_020370 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) MC60_020385 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) MC60_020395 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) MC60_020410 ENOG4105BZU Histidine kinase MC60_020420 ENOG4108J1Q MC60_020435 ENOG4105D82 Glutamate dehydrogenase MC60_020440 ENOG4105FE9 pseudouridine synthase MC60_020445 ENOG4105DJ2 Major Facilitator Superfamily MC60_020455 ENOG4105C5Q Transcriptional regulator MC60_020465 ENOG4106428 Protein of unknown function (DUF2496) MC60_020475 ENOG4108Q2J Inner membrane protein YebE MC60_020485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC60_020490 ENOG4105C4M (Ubiquinol oxidase) subunit I MC60_020495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MC60_020505 ENOG4105F27 Major Facilitator MC60_020515 ENOG4105CV8 reductase MC60_020535 ENOG4105HEI LysR family (Transcriptional regulator MC60_020540 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MC60_020545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MC60_020550 ENOG4105CXY transporter MC60_020555 ENOG4105E98 transcriptional regulator DeoR family MC60_020565 ENOG4105C6V Glycerol-3-phosphate dehydrogenase MC60_020570 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase MC60_020575 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) MC60_020590 ENOG4108WFC UPF0438 protein yifE MC60_020595 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) MC60_020615 ENOG4105CUG Oligopeptidase b MC60_020620 ENOG4105D05 Receptor MC60_020625 ENOG4105E68 Sulfatase MC60_020630 ENOG4105PAN UPF0352 protein MC60_020635 ENOG4106V8H Nucleoid-associated protein MC60_020640 ENOG4107FKK extracellular solute-binding protein family 1 MC60_020645 ENOG4105D56 permease protein MC60_020650 ENOG4105EG2 ABC transporter, permease MC60_020655 ENOG4108IJ9 (ABC) transporter MC60_020660 ENOG4105CSR polyphosphate kinase 2 MC60_020680 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) MC60_020685 ENOG4105ERG peptidase m48, ste24p MC60_020695 ENOG4105K89 arsenate reductase MC60_020710 ENOG4108ZYK Acyl carrier protein phosphodiesterase MC60_020720 ENOG4106PMH Extracellular solute-binding protein family 3 MC60_020725 ENOG4105DYB Isoaspartyl dipeptidase MC60_020730 ENOG4105DWU Membrane MC60_020735 ENOG4108JEH abc transporter atp-binding protein MC60_020740 ENOG4106PMH Extracellular solute-binding protein family 3 MC60_020745 ENOG4105DSP amino acid AbC transporter MC60_020750 ENOG4106YG3 ABC transporter MC60_020760 ENOG4105F1A Pyruvate formate-lyase MC60_020765 ENOG4105BZU Histidine kinase MC60_020770 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase MC60_020785 ENOG4105J12 Multidrug resistance protein mdtN MC60_020795 ENOG4105IPI Membrane