locus-tag	class	description
LCG53_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCG53_00010	COG0592	DNA-directed DNA polymerase activity
LCG53_00020	COG0187	DNA topoisomerase II activity
LCG53_00025	COG2207	Transcriptional regulator
LCG53_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LCG53_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
LCG53_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
LCG53_00045	COG3977	Valine--pyruvate aminotransferase
LCG53_00060	COG2814	Major facilitator Superfamily
LCG53_00065	COG0745	RESPONSE REGULATOR receiver
LCG53_00070	COG2205	protein histidine kinase activity
LCG53_00105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCG53_00110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_00110	COG4191	Histidine kinase
LCG53_00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_00125	COG1309	transcriptional regulator
LCG53_00155	COG0561	phosphatase activity
LCG53_00160	COG2267	carboxylic ester hydrolase activity
LCG53_00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCG53_00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCG53_00175	COG1758	RNA polymerase activity
LCG53_00185	COG0859	PFAM glycosyl transferase family 9
LCG53_00190	COG3642	lipopolysaccharide core region biosynthetic process
LCG53_00230	COG0589	response to stress
LCG53_00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LCG53_00240	COG3706	GGDEF domain
LCG53_00245	COG1528	Iron-storage protein
LCG53_00250	COG2081	HI0933 family
LCG53_00255	COG2223	nitrite transmembrane transporter activity
LCG53_00260	COG1280	lysine exporter protein (LysE YggA)
LCG53_00275	COG3188	usher protein
LCG53_00295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_00295	COG2205	protein histidine kinase activity
LCG53_00305	COG3275	phosphorelay sensor kinase activity
LCG53_00310	COG3279	Response regulator of the LytR AlgR family
LCG53_00315	COG2223	nitrite transmembrane transporter activity
LCG53_00320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LCG53_00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LCG53_00370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LCG53_00375	COG2166	iron-sulfur cluster assembly
LCG53_00380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LCG53_00400	COG1063	alcohol dehydrogenase
LCG53_00405	COG0156	8-amino-7-oxononanoate synthase activity
LCG53_00415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCG53_00460	COG1609	Transcriptional regulator
LCG53_00475	COG1580	Controls the rotational direction of flagella during chemotaxis
LCG53_00480	COG3161	chorismate lyase activity
LCG53_00485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LCG53_00490	COG2937	Belongs to the GPAT DAPAT family
LCG53_00495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LCG53_00510	COG0534	Mate efflux family protein
LCG53_00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LCG53_00520	COG2205	protein histidine kinase activity
LCG53_00525	COG0745	RESPONSE REGULATOR receiver
LCG53_00535	COG1045	serine acetyltransferase
LCG53_00545	COG3074	FtsZ-dependent cytokinesis
LCG53_00550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LCG53_00555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCG53_00555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCG53_00560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LCG53_00600	COG1609	Transcriptional regulator
LCG53_00605	COG3250	beta-galactosidase activity
LCG53_00610	COG2731	YhcH YjgK YiaL family protein
LCG53_00615	COG0531	amino acid
LCG53_00620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCG53_00625	COG0531	amino acid
LCG53_00630	COG0385	Bile acid
LCG53_00635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LCG53_00660	COG0583	DNA-binding transcription factor activity
LCG53_00665	COG1079	Belongs to the binding-protein-dependent transport system permease family
LCG53_00670	COG4603	Belongs to the binding-protein-dependent transport system permease family
LCG53_00675	COG3845	ABC transporter
LCG53_00680	COG1744	ABC transporter substrate-binding protein PnrA-like
LCG53_00685	COG0210	DNA helicase
LCG53_00695	COG1943	Transposase
LCG53_00700	COG0583	DNA-binding transcription factor activity
LCG53_00735	COG0583	DNA-binding transcription factor activity
LCG53_00750	COG1280	lysine exporter protein (LysE YggA)
LCG53_00760	COG2962	Rard protein
LCG53_00770	COG1012	belongs to the aldehyde dehydrogenase family
LCG53_00775	COG1396	sequence-specific DNA binding
LCG53_00780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCG53_00790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCG53_00790	COG0519	Catalyzes the synthesis of GMP from XMP
LCG53_00800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCG53_00820	COG1322	Protein conserved in bacteria
LCG53_00825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCG53_00830	COG0569	domain protein
LCG53_00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCG53_00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCG53_00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LCG53_00845	COG0242	peptide deformylase activity
LCG53_00855	COG0758	DNA mediated transformation
LCG53_00860	COG2922	Belongs to the Smg family
LCG53_00865	COG0551	DNA topoisomerase type I activity
LCG53_00870	COG0009	L-threonylcarbamoyladenylate synthase
LCG53_00875	COG0408	coproporphyrinogen oxidase activity
LCG53_00880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LCG53_00885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LCG53_00895	COG3078	GTPase activator activity
LCG53_00905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCG53_00910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LCG53_00920	COG3852	Histidine kinase
LCG53_00930	COG0174	glutamine synthetase
LCG53_00935	COG1217	gtp-binding protein TYPA
LCG53_00940	COG1295	ribonuclease BN
LCG53_00945	COG1490	D-aminoacyl-tRNA deacylase activity
LCG53_00955	COG0456	acetyltransferase
LCG53_00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LCG53_00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCG53_00975	COG2610	gluconate transmembrane transporter activity
LCG53_00980	COG3265	gluconokinase activity
LCG53_00985	COG0129	dihydroxy-acid dehydratase activity
LCG53_00990	COG0800	Aldolase
LCG53_01005	COG1609	Transcriptional regulator
LCG53_01015	COG4942	peptidase
LCG53_01020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LCG53_01025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCG53_01030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LCG53_01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LCG53_01040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LCG53_01040	COG0316	Belongs to the HesB IscA family
LCG53_01045	COG1040	competence protein
LCG53_01050	COG0596	Alpha beta hydrolase
LCG53_01065	COG2183	response to ionizing radiation
LCG53_01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LCG53_01080	COG2205	protein histidine kinase activity
LCG53_01090	COG0051	transcription antitermination factor activity, RNA binding
LCG53_01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LCG53_01100	COG0088	Forms part of the polypeptide exit tunnel
LCG53_01105	COG0089	rRNA binding
LCG53_01110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LCG53_01115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LCG53_01120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LCG53_01125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LCG53_01130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LCG53_01135	COG0255	Belongs to the universal ribosomal protein uL29 family
LCG53_01140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LCG53_01145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LCG53_01150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LCG53_01155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LCG53_01160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LCG53_01165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LCG53_01170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LCG53_01175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LCG53_01180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LCG53_01185	COG1841	ribosomal large subunit assembly
LCG53_01190	COG0200	Binds to the 23S rRNA
LCG53_01195	COG0201	protein transport
LCG53_01200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LCG53_01205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LCG53_01210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LCG53_01215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LCG53_01220	COG0202	RNA polymerase activity
LCG53_01225	COG0203	ribosomal protein L17
LCG53_01275	COG2249	NAD(P)H dehydrogenase (quinone) activity
LCG53_01280	COG0583	DNA-binding transcription factor activity
LCG53_01285	COG4221	oxidoreductase activity
LCG53_01300	COG1770	oligopeptidase
LCG53_01305	COG2358	TRAP transporter, solute receptor (TAXI family
LCG53_01320	COG3714	YhhN family
LCG53_01335	COG0583	DNA-binding transcription factor activity
LCG53_01345	COG1301	dicarboxylic acid transport
LCG53_01355	COG2095	MarC family integral membrane protein
LCG53_01365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCG53_01375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LCG53_01385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCG53_01410	COG0742	ribosomal rna small subunit methyltransferase
LCG53_01415	COG0552	protein localization to endoplasmic reticulum
LCG53_01420	COG2884	Cell division ATP-binding protein ftsE
LCG53_01425	COG2177	Part of the ABC transporter FtsEX involved in
LCG53_01435	COG0288	reversible hydration of carbon dioxide
LCG53_01440	COG2188	Transcriptional regulator
LCG53_01445	COG1228	amidohydrolase
LCG53_01450	COG0010	Belongs to the arginase family
LCG53_01455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LCG53_01460	COG2986	histidine ammonia-lyase
LCG53_01465	COG0387	Pfam Sodium calcium exchanger
LCG53_01470	COG2200	EAL domain
LCG53_01520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCG53_01525	COG1459	type II secretion system
LCG53_01570	COG1077	Cell shape determining protein MreB Mrl
LCG53_01575	COG1792	Involved in formation and maintenance of cell shape
LCG53_01580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LCG53_01585	COG0424	maF-like protein
LCG53_01590	COG1530	ribonuclease E activity
LCG53_01595	COG3164	Protein of unknown function
LCG53_01600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCG53_01605	COG0312	modulator of DNA gyrase
LCG53_01620	COG0477	Major facilitator Superfamily
LCG53_01630	COG2321	neutral zinc metallopeptidase
LCG53_01665	COG0189	ligase activity
LCG53_01670	COG0642	Histidine kinase
LCG53_01675	COG0745	RESPONSE REGULATOR receiver
LCG53_01690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LCG53_01695	COG0352	thiamine-phosphate diphosphorylase activity
LCG53_01700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCG53_01710	COG2022	thiamine diphosphate biosynthetic process
LCG53_01715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LCG53_01735	COG0110	maltose O-acetyltransferase activity
LCG53_01750	COG3932	Exopolysaccharide synthesis, ExoD
LCG53_01765	COG1733	regulation of RNA biosynthetic process
LCG53_01790	COG2226	methyltransferase
LCG53_01800	COG1494	fructose-1,6-bisphosphatase
LCG53_01810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LCG53_01815	COG5007	Belongs to the BolA IbaG family
LCG53_01825	COG2854	intermembrane phospholipid transfer
LCG53_01830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LCG53_01835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LCG53_01840	COG1127	ABC transporter
LCG53_01845	COG0517	IMP dehydrogenase activity
LCG53_01845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LCG53_01850	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LCG53_01860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LCG53_01865	COG1137	ATPase activity
LCG53_01870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LCG53_01880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_01885	COG1660	Displays ATPase and GTPase activities
LCG53_01890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_01910	COG3964	amidohydrolase
LCG53_01940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCG53_01945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCG53_01955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LCG53_01960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LCG53_01965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LCG53_01970	COG0723	plastoquinol--plastocyanin reductase activity
LCG53_01975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LCG53_01980	COG2857	Cytochrome c1
LCG53_01985	COG0625	glutathione transferase activity
LCG53_01990	COG2969	positive regulation of protein catabolic process
LCG53_01995	COG2823	Periplasmic or secreted lipoprotein
LCG53_02000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LCG53_02005	COG0792	nuclease activity
LCG53_02010	COG3107	peptidoglycan biosynthetic process
LCG53_02015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LCG53_02025	COG2001	Belongs to the MraZ family
LCG53_02030	COG0275	rRNA processing
LCG53_02035	COG3116	cell division
LCG53_02040	COG0768	penicillin binding
LCG53_02045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LCG53_02050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LCG53_02055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCG53_02060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LCG53_02065	COG0772	Belongs to the SEDS family
LCG53_02070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LCG53_02075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCG53_02080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LCG53_02085	COG0849	cell division
LCG53_02090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LCG53_02095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LCG53_02105	COG0653	protein targeting
LCG53_02115	COG0494	nUDIX hydrolase
LCG53_02120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LCG53_02125	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LCG53_02140	COG1459	type II secretion system
LCG53_02145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCG53_02170	COG2186	Transcriptional regulator
LCG53_02175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LCG53_02180	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCG53_02185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCG53_02195	COG0840	transmembrane signaling receptor activity
LCG53_02200	COG0840	transmembrane signaling receptor activity
LCG53_02205	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCG53_02210	COG1049	propionate catabolic process, 2-methylcitrate cycle
LCG53_02215	COG2200	EAL domain
LCG53_02225	COG1280	lysine exporter protein (LysE YggA)
LCG53_02235	COG0523	cobalamin synthesis protein
LCG53_02240	COG0477	Major facilitator Superfamily
LCG53_02255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LCG53_02260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LCG53_02310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LCG53_02330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LCG53_02335	COG0732	type I restriction modification DNA specificity domain
LCG53_02340	COG1401	restriction endodeoxyribonuclease activity
LCG53_02340	COG1401	restriction endodeoxyribonuclease activity
LCG53_02350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LCG53_02395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCG53_02410	COG1546	Belongs to the CinA family
LCG53_02415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LCG53_02420	COG2137	regulation of response to DNA damage stimulus
LCG53_02425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCG53_02430	COG0527	aspartate kinase activity
LCG53_02435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LCG53_02470	COG1686	Belongs to the peptidase S11 family
LCG53_02475	COG0586	Pfam SNARE associated Golgi protein
LCG53_02480	COG1253	flavin adenine dinucleotide binding
LCG53_02485	COG0525	valine-tRNA ligase activity
LCG53_02490	COG2927	DNA polymerase III (CHI subunit)
LCG53_02495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LCG53_02500	COG0795	lipopolysaccharide-transporting ATPase activity
LCG53_02505	COG0795	lipopolysaccharide-transporting ATPase activity
LCG53_02680	COG4695	Portal protein
LCG53_02780	COG4974	Belongs to the 'phage' integrase family
LCG53_02945	COG4695	Portal protein
LCG53_03045	COG4974	Belongs to the 'phage' integrase family
LCG53_03050	COG0582	viral genome integration into host DNA
LCG53_03105	COG0004	ammonium transporteR
LCG53_03110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCG53_03125	COG2165	general secretion pathway protein
LCG53_03130	COG0084	hydrolase, TatD family'
LCG53_03135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCG53_03145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LCG53_03150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LCG53_03155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LCG53_03160	COG0813	purine-nucleoside phosphorylase activity
LCG53_03165	COG5002	protein histidine kinase activity
LCG53_03165	COG3447	MASE1 domain protein
LCG53_03165	COG5001	Diguanylate cyclase
LCG53_03175	COG0560	Phosphoserine phosphatase
LCG53_03190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LCG53_03200	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LCG53_03205	COG0776	regulation of translation
LCG53_03220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCG53_03225	COG0735	belongs to the Fur family
LCG53_03245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LCG53_03250	COG0513	Belongs to the DEAD box helicase family
LCG53_03255	COG3022	response to hydroperoxide
LCG53_03270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LCG53_03275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LCG53_03280	COG0762	integral membrane protein
LCG53_03285	COG1872	DUF167
LCG53_03305	COG3112	Uncharacterised protein family (UPF0231)
LCG53_03310	COG3835	regulator
LCG53_03315	COG2610	gluconate transmembrane transporter activity
LCG53_03320	COG1929	Belongs to the glycerate kinase type-1 family
LCG53_03335	COG0583	DNA-binding transcription factor activity
LCG53_03340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCG53_03355	COG0347	Belongs to the P(II) protein family
LCG53_03360	COG1840	ABC-type Fe3 transport system, periplasmic component
LCG53_03370	COG3842	ATPase activity
LCG53_03375	COG2837	iron assimilation
LCG53_03380	COG1438	arginine binding
LCG53_03385	COG1126	abc transporter atp-binding protein
LCG53_03390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_03395	COG4215	(ABC) transporter
LCG53_03400	COG4160	amino acid transport
LCG53_03405	COG0039	L-malate dehydrogenase activity
LCG53_03410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LCG53_03415	COG1017	nitric oxide dioxygenase activity
LCG53_03415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LCG53_03425	COG4536	flavin adenine dinucleotide binding
LCG53_03430	COG4137	Cytochrome C assembly protein
LCG53_03435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LCG53_03440	COG0228	four-way junction DNA binding
LCG53_03445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LCG53_03450	COG0336	Belongs to the RNA methyltransferase TrmD family
LCG53_03455	COG0335	large ribosomal subunit rRNA binding
LCG53_03470	COG1051	belongs to the nudix hydrolase family
LCG53_03480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LCG53_03485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LCG53_03490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LCG53_03500	COG0583	DNA-binding transcription factor activity
LCG53_03505	COG0640	Transcriptional regulator
LCG53_03510	COG0268	Binds directly to 16S ribosomal RNA
LCG53_03515	COG0728	peptidoglycan biosynthetic process
LCG53_03520	COG0196	riboflavin kinase activity
LCG53_03525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LCG53_03530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LCG53_03535	COG1047	Peptidyl-prolyl cis-trans
LCG53_03540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LCG53_03580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LCG53_03580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCG53_03595	COG1854	S-ribosylhomocysteine lyase activity
LCG53_03600	COG3706	GGDEF domain
LCG53_03605	COG0557	exoribonuclease II activity
LCG53_03610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCG53_03620	COG2153	protein acetylation
LCG53_03630	COG1914	H( )-stimulated, divalent metal cation uptake system
LCG53_03635	COG0360	Binds together with S18 to 16S ribosomal RNA
LCG53_03640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LCG53_03645	COG0359	binds to the 23S rRNA
LCG53_03685	COG1238	metal cluster binding
LCG53_03690	COG0612	Peptidase, M16
LCG53_03695	COG2918	glutathione biosynthetic process
LCG53_03700	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LCG53_03705	COG1027	Aspartate ammonia-lyase
LCG53_03710	COG3030	protein affecting phage T7 exclusion by the F plasmid
LCG53_03715	COG0534	Mate efflux family protein
LCG53_03720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LCG53_03725	COG0459	protein refolding
LCG53_03745	COG0564	pseudouridine synthase activity
LCG53_03750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCG53_03785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LCG53_03795	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LCG53_03800	COG4208	sulfate ABC transporter
LCG53_03805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LCG53_03810	COG0583	DNA-binding transcription factor activity
LCG53_03815	COG3397	chitin binding
LCG53_03820	COG0840	transmembrane signaling receptor activity
LCG53_03845	COG1328	CTP reductase activity
LCG53_03850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LCG53_03865	COG1448	Aminotransferase
LCG53_03890	COG1215	transferase activity, transferring glycosyl groups
LCG53_03905	COG0457	Tetratricopeptide repeat
LCG53_03905	COG3118	belongs to the thioredoxin family
LCG53_03935	COG2948	multi-organism process
LCG53_03965	COG3451	type IV secretory pathway VirB4
LCG53_03975	COG3838	Conjugal transfer protein Trbc
LCG53_03980	COG4962	Type ii secretion system protein e
LCG53_04000	COG0583	DNA-binding transcription factor activity
LCG53_04025	COG2076	Multidrug Resistance protein
LCG53_04045	COG4959	Type IV secretory pathway protease TraF
LCG53_04060	COG1192	Involved in chromosome partitioning
LCG53_04090	COG5489	Protein of unknown function (DUF736)
LCG53_04120	COG2003	Belongs to the UPF0758 family
LCG53_04190	COG0513	Belongs to the DEAD box helicase family
LCG53_04195	COG0840	transmembrane signaling receptor activity
LCG53_04205	COG4166	transmembrane transport
LCG53_04220	COG1024	Enoyl-CoA hydratase
LCG53_04235	COG4221	oxidoreductase activity
LCG53_04240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCG53_04245	COG0442	prolyl-tRNA aminoacylation
LCG53_04255	COG0632	four-way junction helicase activity
LCG53_04260	COG2255	four-way junction helicase activity
LCG53_04270	COG1271	oxidase subunit
LCG53_04275	COG1294	oxidase, subunit
LCG53_04280	COG4890	Cyd operon protein YbgT
LCG53_04285	COG3790	cyd operon protein YbgE
LCG53_04290	COG0824	Thioesterase
LCG53_04295	COG0811	peptide transport
LCG53_04310	COG0823	Involved in the tonB-independent uptake of proteins
LCG53_04315	COG2885	chlorophyll binding
LCG53_04320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LCG53_04395	COG0840	transmembrane signaling receptor activity
LCG53_04400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LCG53_04410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCG53_04415	COG1640	4-alpha-glucanotransferase
LCG53_04420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LCG53_04450	COG2130	NADP-dependent
LCG53_04455	COG1846	Transcriptional regulator
LCG53_04485	COG0561	phosphatase activity
LCG53_04500	COG0733	neurotransmitter:sodium symporter activity
LCG53_04505	COG0733	neurotransmitter:sodium symporter activity
LCG53_04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCG53_04535	COG1794	racemase activity, acting on amino acids and derivatives
LCG53_04550	COG1022	Amp-dependent synthetase and ligase
LCG53_04560	COG0456	acetyltransferase
LCG53_04575	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LCG53_04580	COG5001	Diguanylate cyclase
LCG53_04580	COG5002	protein histidine kinase activity
LCG53_04600	COG0456	acetyltransferase
LCG53_04620	COG1902	pentaerythritol trinitrate reductase activity
LCG53_04635	COG2957	Belongs to the agmatine deiminase family
LCG53_04640	COG0154	amidase activity
LCG53_04665	COG2207	Transcriptional regulator
LCG53_04665	COG1917	Cupin 2, conserved barrel domain protein
LCG53_04675	COG0513	Belongs to the DEAD box helicase family
LCG53_04680	COG2203	Gaf domain
LCG53_04680	COG2199	diguanylate cyclase activity
LCG53_04715	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LCG53_04725	COG1136	(ABC) transporter
LCG53_04725	COG0577	efflux transmembrane transporter activity
LCG53_04730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_04735	COG0745	RESPONSE REGULATOR receiver
LCG53_04740	COG2205	protein histidine kinase activity
LCG53_04795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCG53_04805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LCG53_04815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LCG53_04820	COG1178	ABC-type Fe3 transport system permease component
LCG53_04825	COG4143	(ABC) transporter
LCG53_04840	COG0066	3-isopropylmalate dehydratase activity
LCG53_04845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LCG53_04850	COG0473	3-isopropylmalate dehydrogenase activity
LCG53_04855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCG53_04865	COG0671	phosphoesterase, PA-phosphatase related
LCG53_04880	COG0028	Belongs to the TPP enzyme family
LCG53_04885	COG0440	acetolactate synthase activity
LCG53_04890	COG0857	belongs to the CobB CobQ family
LCG53_04890	COG0280	phosphate acetyltransferase
LCG53_04895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LCG53_04900	COG3092	negative regulation of chromosome organization
LCG53_04905	COG3013	Belongs to the UPF0304 family
LCG53_04910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LCG53_04915	COG2716	regulation of RNA biosynthetic process
LCG53_04920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCG53_04925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LCG53_04930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LCG53_04945	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LCG53_04965	COG2198	Histidine kinase
LCG53_04965	COG5002	protein histidine kinase activity
LCG53_04965	COG0784	Response regulator, receiver
LCG53_04970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LCG53_04985	COG0784	Response regulator, receiver
LCG53_04985	COG2205	protein histidine kinase activity
LCG53_04995	COG0840	transmembrane signaling receptor activity
LCG53_05005	COG1464	Belongs to the NlpA lipoprotein family
LCG53_05010	COG2011	ABC-type metal ion transport system permease component
LCG53_05015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LCG53_05035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LCG53_05035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LCG53_05040	COG0802	atpase or kinase
LCG53_05050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LCG53_05055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LCG53_05060	COG1923	regulation of RNA biosynthetic process
LCG53_05065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LCG53_05070	COG0330	HflC and HflK could
LCG53_05075	COG0330	HflC and HflK could
LCG53_05080	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LCG53_05085	COG0142	geranyltranstransferase activity
LCG53_05090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LCG53_05095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LCG53_05100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LCG53_05105	COG3314	Sporulation integral membrane protein YlbJ
LCG53_05110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LCG53_05115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCG53_05125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCG53_05130	COG2967	ApaG domain
LCG53_05135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LCG53_05140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LCG53_05150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LCG53_05155	COG3178	'Phosphotransferase
LCG53_05160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LCG53_05165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LCG53_05170	COG2252	PERMEase
LCG53_05180	COG0488	(ABC) transporter
LCG53_05185	COG0741	lytic transglycosylase activity
LCG53_05190	COG0463	Glycosyl transferase, family 2
LCG53_05200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LCG53_05225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCG53_05235	COG3721	Heme iron utilization protein
LCG53_05240	COG0748	coenzyme F420 binding
LCG53_05265	COG2814	Major facilitator Superfamily
LCG53_05270	COG2205	protein histidine kinase activity
LCG53_05270	COG2202	Pas domain
LCG53_05280	COG2226	methyltransferase
LCG53_05290	COG1765	OsmC-like protein
LCG53_05305	COG3954	Phosphoribulokinase
LCG53_05310	COG3089	Belongs to the UPF0270 family
LCG53_05315	COG2203	Gaf domain
LCG53_05315	COG3706	GGDEF domain
LCG53_05315	COG4251	negative regulation of phosphorylation
LCG53_05315	COG5001	Diguanylate cyclase
LCG53_05320	COG0429	hydrolase of the alpha beta-hydrolase fold
LCG53_05325	COG0784	Response regulator, receiver
LCG53_05325	COG0835	chemotaxis
LCG53_05335	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LCG53_05340	COG1047	Peptidyl-prolyl cis-trans
LCG53_05345	COG2900	Belongs to the SlyX family
LCG53_05355	COG0545	Peptidyl-prolyl cis-trans isomerase
LCG53_05360	COG2204	response regulator
LCG53_05380	COG0737	Belongs to the 5'-nucleotidase family
LCG53_05395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCG53_05400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LCG53_05400	COG0506	proline dehydrogenase activity
LCG53_05400	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LCG53_05410	COG0114	fumarate hydratase activity
LCG53_05420	COG1566	PFAM secretion protein HlyD family protein
LCG53_05490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCG53_05500	COG1280	lysine exporter protein (LysE YggA)
LCG53_05505	COG0826	peptidase U32
LCG53_05515	COG3813	Protein conserved in bacteria
LCG53_05535	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LCG53_05560	COG0300	oxidoreductase activity
LCG53_05580	COG2610	gluconate transmembrane transporter activity
LCG53_05585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCG53_05590	COG3622	Belongs to the hyi family
LCG53_05595	COG0235	Class ii aldolase
LCG53_05605	COG2084	Dehydrogenase
LCG53_05610	COG1349	DNA-binding transcription factor activity
LCG53_05620	COG2133	pyrroloquinoline quinone binding
LCG53_05660	COG4397	Mu-like prophage major head subunit gpT
LCG53_05695	COG0077	Prephenate dehydratase
LCG53_05695	COG1605	Chorismate mutase
LCG53_05720	COG3272	Protein of unknown function (DUF1722)
LCG53_05725	COG0789	Transcriptional regulator
LCG53_05730	COG0415	Belongs to the DNA photolyase family
LCG53_05740	COG4221	oxidoreductase activity
LCG53_05755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LCG53_05780	COG0783	Belongs to the Dps family
LCG53_05785	COG1151	hydroxylamine reductase activity
LCG53_05790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LCG53_05795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCG53_05810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_05815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_05825	COG0745	RESPONSE REGULATOR receiver
LCG53_05830	COG5002	protein histidine kinase activity
LCG53_05830	COG5000	phosphorelay sensor kinase activity
LCG53_05840	COG0659	secondary active sulfate transmembrane transporter activity
LCG53_05850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LCG53_05855	COG1666	GTP binding
LCG53_05865	COG2211	Major facilitator Superfamily
LCG53_05875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LCG53_05885	COG2813	Specifically methylates the guanine in position
LCG53_05890	COG0271	Belongs to the BolA IbaG family
LCG53_05895	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LCG53_05900	COG1805	sodium ion transport
LCG53_05905	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LCG53_05910	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LCG53_05915	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LCG53_05920	COG2871	sodium ion transport
LCG53_05925	COG1477	protein flavinylation
LCG53_05940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCG53_05945	COG0840	transmembrane signaling receptor activity
LCG53_05950	COG0583	DNA-binding transcription factor activity
LCG53_05965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LCG53_05975	COG0473	3-isopropylmalate dehydrogenase activity
LCG53_05980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCG53_05985	COG1611	Belongs to the LOG family
LCG53_06000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LCG53_06000	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LCG53_06010	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LCG53_06035	COG3098	single-species biofilm formation
LCG53_06040	COG0564	pseudouridine synthase activity
LCG53_06055	COG4580	involved in the transport of maltose and maltodextrins
LCG53_06065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_06065	COG1263	PTS System
LCG53_06075	COG2171	N-acyltransferase activity
LCG53_06080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LCG53_06085	COG0024	Methionine aminopeptidase
LCG53_06090	COG0052	Belongs to the universal ribosomal protein uS2 family
LCG53_06095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LCG53_06100	COG0528	UMP kinase activity
LCG53_06105	COG0233	cytoplasmic translational termination
LCG53_06110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LCG53_06115	COG0575	Belongs to the CDS family
LCG53_06120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LCG53_06125	COG0750	zinc metalloprotease
LCG53_06140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCG53_06145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LCG53_06150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCG53_06155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCG53_06160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LCG53_06165	COG0587	DNA-directed DNA polymerase activity
LCG53_06170	COG0825	malonyl-CoA metabolic process
LCG53_06185	COG0814	amino acid
LCG53_06190	COG0531	amino acid
LCG53_06200	COG0488	(ABC) transporter
LCG53_06210	COG3590	peptidase
LCG53_06215	COG0037	tRNA processing
LCG53_06220	COG3706	GGDEF domain
LCG53_06255	COG0366	Alpha amylase catalytic
LCG53_06270	COG0463	Glycosyl transferase, family 2
LCG53_06285	COG2989	Protein conserved in bacteria
LCG53_06290	COG3108	Peptidase M15
LCG53_06300	COG2860	membrane
LCG53_06310	COG1196	nuclear chromosome segregation
LCG53_06315	COG3115	cell septum assembly
LCG53_06320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LCG53_06330	COG1328	CTP reductase activity
LCG53_06335	COG0602	queuosine metabolic process
LCG53_06360	COG1566	PFAM secretion protein HlyD family protein
LCG53_06370	COG3290	protein histidine kinase activity
LCG53_06385	COG0667	Aldo Keto reductase
LCG53_06395	COG0697	spore germination
LCG53_06410	COG3284	Transcriptional regulator
LCG53_06415	COG3706	GGDEF domain
LCG53_06420	COG0346	lactoylglutathione lyase activity
LCG53_06425	COG0745	RESPONSE REGULATOR receiver
LCG53_06430	COG5002	protein histidine kinase activity
LCG53_06440	COG4783	chaperone-mediated protein folding
LCG53_06460	COG0545	Peptidyl-prolyl cis-trans isomerase
LCG53_06465	COG1131	(ABC) transporter
LCG53_06470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LCG53_06480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_06485	COG4597	amino acid ABC transporter
LCG53_06490	COG0765	amino acid transport
LCG53_06495	COG1126	abc transporter atp-binding protein
LCG53_06505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LCG53_06510	COG0678	peroxiredoxin activity
LCG53_06520	COG0019	diaminopimelate decarboxylase activity
LCG53_06525	COG1115	amino acid carrier protein
LCG53_06530	COG0095	Lipoate-protein ligase
LCG53_06535	COG2233	PERMEase
LCG53_06555	COG2207	Transcriptional regulator
LCG53_06560	COG0281	malic enzyme
LCG53_06590	COG0733	neurotransmitter:sodium symporter activity
LCG53_06595	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCG53_06600	COG3706	GGDEF domain
LCG53_06610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_06615	COG1032	radical SAM domain protein
LCG53_06620	COG3903	Transcriptional regulator
LCG53_06620	COG2319	Wd-40 repeat
LCG53_06640	COG0673	inositol 2-dehydrogenase activity
LCG53_06645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LCG53_06650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LCG53_06680	COG0739	heme binding
LCG53_06680	COG0741	lytic transglycosylase activity
LCG53_06680	COG1196	nuclear chromosome segregation
LCG53_06705	COG0788	formyltetrahydrofolate deformylase activity
LCG53_06710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCG53_06720	COG3118	belongs to the thioredoxin family
LCG53_06730	COG0791	NLP P60 protein
LCG53_06735	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LCG53_06750	COG1388	LysM domain
LCG53_06750	COG1376	ErfK ybiS ycfS ynhG family protein
LCG53_06840	COG0583	DNA-binding transcription factor activity
LCG53_06870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LCG53_06885	COG4959	Type IV secretory pathway protease TraF
LCG53_06935	COG1203	CRISPR-associated helicase, Cas3
LCG53_06940	COG1518	maintenance of DNA repeat elements
LCG53_06975	COG2003	Belongs to the UPF0758 family
LCG53_07020	COG3311	Transcriptional regulator
LCG53_07035	COG0582	viral genome integration into host DNA
LCG53_07040	COG0784	Response regulator, receiver
LCG53_07040	COG2205	protein histidine kinase activity
LCG53_07065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_07065	COG2205	protein histidine kinase activity
LCG53_07070	COG3384	dioxygenase
LCG53_07080	COG1283	sodium-dependent phosphate transmembrane transporter activity
LCG53_07090	COG0531	amino acid
LCG53_07095	COG0531	amino acid
LCG53_07110	COG1012	belongs to the aldehyde dehydrogenase family
LCG53_07115	COG1396	sequence-specific DNA binding
LCG53_07115	COG1917	Cupin 2, conserved barrel domain protein
LCG53_07120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCG53_07155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCG53_07155	COG4651	solute:proton antiporter activity
LCG53_07170	COG2974	May be involved in recombination
LCG53_07175	COG1247	-acetyltransferase
LCG53_07180	COG0420	3'-5' exonuclease activity
LCG53_07190	COG3038	cytochrome b561
LCG53_07195	COG2190	(PTS) system
LCG53_07205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_07210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCG53_07215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCG53_07230	COG1720	tRNA m6t6A37 methyltransferase activity
LCG53_07250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LCG53_07255	COG4988	ABC transporter
LCG53_07270	COG0745	RESPONSE REGULATOR receiver
LCG53_07280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LCG53_07295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LCG53_07300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LCG53_07310	COG0083	homoserine kinase activity
LCG53_07315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LCG53_07335	COG1943	Transposase
LCG53_07345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LCG53_07355	COG3220	belongs to the UPF0276 family
LCG53_07385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LCG53_07390	COG1289	transmembrane transporter activity
LCG53_07395	COG1763	Mo-molybdopterin cofactor biosynthetic process
LCG53_07400	COG0746	molybdenum cofactor guanylyltransferase activity
LCG53_07405	COG0281	malic enzyme
LCG53_07435	COG3264	Mechanosensitive ion channel
LCG53_07435	COG1196	nuclear chromosome segregation
LCG53_07445	COG2850	peptidyl-arginine hydroxylation
LCG53_07450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LCG53_07455	COG2915	High frequency lysogenization protein hflD homolog
LCG53_07460	COG0482	sulfurtransferase activity
LCG53_07470	COG1187	pseudouridine synthase activity
LCG53_07475	COG0456	acetyltransferase
LCG53_07510	COG0538	isocitrate dehydrogenase activity
LCG53_07520	COG3048	D-serine ammonia-lyase activity
LCG53_07525	COG0583	DNA-binding transcription factor activity
LCG53_07530	COG2916	Histone family protein nucleoid-structuring protein H-NS
LCG53_07535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCG53_07540	COG2375	cellular response to nickel ion
LCG53_07545	COG1538	Outer membrane efflux protein
LCG53_07550	COG0577	efflux transmembrane transporter activity
LCG53_07550	COG1136	(ABC) transporter
LCG53_07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_07565	COG0497	DNA recombination
LCG53_07570	COG3706	GGDEF domain
LCG53_07575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LCG53_07580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LCG53_07585	COG0443	Heat shock 70 kDa protein
LCG53_07590	COG0484	heat shock protein binding
LCG53_07620	COG1285	pathogenesis
LCG53_07630	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCG53_07640	COG0640	Transcriptional regulator
LCG53_07670	COG0095	Lipoate-protein ligase
LCG53_07685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_07700	COG0708	Exodeoxyribonuclease III
LCG53_07710	COG0745	RESPONSE REGULATOR receiver
LCG53_07725	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LCG53_07740	COG1846	Transcriptional regulator
LCG53_07760	COG0583	DNA-binding transcription factor activity
LCG53_07765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCG53_07770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LCG53_07775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LCG53_07780	COG1845	cytochrome c oxidase, subunit III
LCG53_07785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LCG53_07790	COG0109	protoheme IX farnesyltransferase activity
LCG53_07800	COG2814	Major facilitator Superfamily
LCG53_07805	COG5507	3-demethylubiquinone-9 3-methyltransferase
LCG53_07815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCG53_07820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LCG53_07825	COG4521	taurine ABC transporter
LCG53_07850	COG3550	peptidyl-serine autophosphorylation
LCG53_07855	COG1396	sequence-specific DNA binding
LCG53_07870	COG0159	tryptophan synthase activity
LCG53_07875	COG0133	tryptophan synthase activity
LCG53_07880	COG0134	indole-3-glycerol-phosphate synthase activity
LCG53_07880	COG0135	phosphoribosylanthranilate isomerase activity
LCG53_07885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCG53_07890	COG0512	Glutamine amidotransferase of anthranilate synthase
LCG53_07890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCG53_07895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LCG53_07900	COG0613	PHP domain protein
LCG53_07905	COG0009	L-threonylcarbamoyladenylate synthase
LCG53_07915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LCG53_07925	COG1946	Acyl-CoA thioesterase
LCG53_07945	COG1309	transcriptional regulator
LCG53_07950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_07955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_07980	COG3039	Transposase
LCG53_08015	COG2003	Belongs to the UPF0758 family
LCG53_08030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LCG53_08045	COG0583	DNA-binding transcription factor activity
LCG53_08065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LCG53_08075	COG1960	acyl-CoA dehydrogenase activity
LCG53_08080	COG0675	Transposase, IS605 OrfB family
LCG53_08100	COG0469	pyruvate kinase activity
LCG53_08105	COG1737	Transcriptional regulator
LCG53_08130	COG0675	Transposase, IS605 OrfB family
LCG53_08150	COG1091	dTDP-4-dehydrorhamnose reductase activity
LCG53_08190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LCG53_08210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCG53_08230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCG53_08295	COG1216	Glycosyl transferase, family 2
LCG53_08315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LCG53_08320	COG3206	protein involved in exopolysaccharide biosynthesis
LCG53_08320	COG0489	protein tyrosine kinase activity
LCG53_08340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCG53_08350	COG3132	Protein of unknown function, DUF480
LCG53_08360	COG0675	Transposase, IS605 OrfB family
LCG53_08385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LCG53_08400	COG1278	Cold shock
LCG53_08425	COG4166	transmembrane transport
LCG53_08430	COG0697	spore germination
LCG53_08435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LCG53_08450	COG4166	transmembrane transport
LCG53_08455	COG0622	Phosphoesterase
LCG53_08470	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LCG53_08475	COG0784	Response regulator, receiver
LCG53_08475	COG0835	chemotaxis
LCG53_08480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LCG53_08485	COG1815	bacterial-type flagellum-dependent cell motility
LCG53_08500	COG1749	Flagellar hook protein flgE
LCG53_08515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LCG53_08520	COG1706	bacterial-type flagellum-dependent cell motility
LCG53_08525	COG3951	Flagellar rod assembly protein muramidase FlgJ
LCG53_08525	COG1705	Flagellar rod assembly protein muramidase FlgJ
LCG53_08540	COG2239	Acts as a magnesium transporter
LCG53_08550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LCG53_08555	COG2716	regulation of RNA biosynthetic process
LCG53_08580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LCG53_08585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LCG53_08590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LCG53_08595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LCG53_08615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LCG53_08635	COG0590	tRNA wobble adenosine to inosine editing
LCG53_08640	COG0573	inorganic phosphate transmembrane transporter activity
LCG53_08645	COG0581	inorganic phosphate transmembrane transporter activity
LCG53_08650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LCG53_08655	COG0704	Plays a role in the regulation of phosphate uptake
LCG53_08660	COG1253	flavin adenine dinucleotide binding
LCG53_08675	COG0531	amino acid
LCG53_08685	COG1126	abc transporter atp-binding protein
LCG53_08690	COG0765	amino acid transport
LCG53_08695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_08700	COG3706	GGDEF domain
LCG53_08705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LCG53_08725	COG1785	Belongs to the alkaline phosphatase family
LCG53_08730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LCG53_08735	COG0477	Major facilitator Superfamily
LCG53_08740	COG0123	including yeast histone deacetylase and acetoin utilization protein
LCG53_08750	COG1199	ATP-dependent helicase activity
LCG53_08765	COG1448	Aminotransferase
LCG53_08770	COG0433	COG0433 Predicted ATPase
LCG53_08785	COG0658	competence protein
LCG53_08785	COG2333	competence protein COMEC
LCG53_08790	COG1132	(ABC) transporter
LCG53_08795	COG1663	tetraacyldisaccharide 4'-kinase activity
LCG53_08800	COG2835	tetraacyldisaccharide 4'-kinase activity
LCG53_08805	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LCG53_08810	COG2197	response regulator
LCG53_08815	COG0322	excinuclease ABC activity
LCG53_08860	COG0604	alcohol dehydrogenase
LCG53_08865	COG1309	transcriptional regulator
LCG53_08870	COG2261	transglycosylase associated protein
LCG53_08875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCG53_08885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LCG53_08890	COG0215	cysteine-tRNA ligase activity
LCG53_08915	COG2203	Gaf domain
LCG53_08915	COG2199	diguanylate cyclase activity
LCG53_08950	COG2119	membrane
LCG53_08955	COG0023	Translation Initiation Factor
LCG53_08965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LCG53_08990	COG4139	cobalamin transport
LCG53_08995	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LCG53_09000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCG53_09005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LCG53_09010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LCG53_09015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LCG53_09020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LCG53_09030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LCG53_09035	COG0505	Belongs to the CarA family
LCG53_09040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LCG53_09045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCG53_09050	COG3706	GGDEF domain
LCG53_09080	COG0513	Belongs to the DEAD box helicase family
LCG53_09090	COG4104	PAAR repeat-containing protein
LCG53_09115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_09120	COG0765	amino acid transport
LCG53_09125	COG1126	abc transporter atp-binding protein
LCG53_09130	COG0493	'glutamate synthase
LCG53_09135	COG0067	glutamate synthase
LCG53_09135	COG0069	glutamate synthase activity
LCG53_09135	COG0070	glutamate synthase
LCG53_09140	COG1242	4 iron, 4 sulfur cluster binding
LCG53_09185	COG1113	amino acid transport
LCG53_09195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LCG53_09200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LCG53_09200	COG0574	Belongs to the PEP-utilizing enzyme family
LCG53_09205	COG1119	ATPase activity
LCG53_09220	COG1464	Belongs to the NlpA lipoprotein family
LCG53_09230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LCG53_09235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LCG53_09245	COG0101	tRNA pseudouridine synthase activity
LCG53_09250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LCG53_09255	COG0285	dihydrofolate synthase activity
LCG53_09260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LCG53_09265	COG2920	part of a sulfur-relay system
LCG53_09270	COG1289	transmembrane transporter activity
LCG53_09275	COG0670	Belongs to the BI1 family
LCG53_09315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LCG53_09320	COG0840	transmembrane signaling receptor activity
LCG53_09325	COG5001	Diguanylate cyclase
LCG53_09330	COG0564	pseudouridine synthase activity
LCG53_09345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LCG53_09355	COG0625	glutathione transferase activity
LCG53_09370	COG0367	asparagine synthase
LCG53_09380	COG0647	UMP catabolic process
LCG53_09385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LCG53_09390	COG0604	alcohol dehydrogenase
LCG53_09395	COG1902	pentaerythritol trinitrate reductase activity
LCG53_09400	COG1253	flavin adenine dinucleotide binding
LCG53_09410	COG0247	lactate metabolic process
LCG53_09410	COG0277	FAD linked oxidase domain protein
LCG53_09420	COG2050	protein possibly involved in aromatic compounds catabolism
LCG53_09435	COG5001	Diguanylate cyclase
LCG53_09440	COG0583	DNA-binding transcription factor activity
LCG53_09445	COG2814	Major facilitator Superfamily
LCG53_09450	COG2056	Na+-H+ antiporter family
LCG53_09455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCG53_09470	COG0483	inositol monophosphate 1-phosphatase activity
LCG53_09480	COG0625	glutathione transferase activity
LCG53_09485	COG0625	glutathione transferase activity
LCG53_09495	COG0601	transmembrane transport
LCG53_09500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCG53_09505	COG0444	Belongs to the ABC transporter superfamily
LCG53_09510	COG2814	Major facilitator Superfamily
LCG53_09530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCG53_09535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCG53_09540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LCG53_09545	COG0509	glycine decarboxylation via glycine cleavage system
LCG53_09550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCG53_09550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCG53_09575	COG3634	alkyl hydroperoxide reductase activity
LCG53_09580	COG0450	alkyl hydroperoxide reductase
LCG53_09585	COG0517	IMP dehydrogenase activity
LCG53_09590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LCG53_09595	COG0343	queuine tRNA-ribosyltransferase activity
LCG53_09600	COG1862	Preprotein translocase
LCG53_09605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCG53_09610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCG53_09615	COG2897	thiosulfate sulfurtransferase activity
LCG53_09625	COG0826	peptidase U32
LCG53_09630	COG0826	peptidase U32
LCG53_09635	COG3154	lipid carrier protein
LCG53_09650	COG1104	cysteine desulfurase activity
LCG53_09655	COG0822	iron-sulfur transferase activity
LCG53_09665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LCG53_09670	COG0443	Heat shock 70 kDa protein
LCG53_09675	COG0633	Ferredoxin
LCG53_09685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LCG53_09690	COG0105	UTP biosynthetic process
LCG53_09695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LCG53_09705	COG1426	Protein conserved in bacteria
LCG53_09715	COG0124	histidyl-tRNA synthetase
LCG53_09720	COG2976	Protein conserved in bacteria
LCG53_09725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCG53_09730	COG1160	GTP binding
LCG53_09735	COG1645	bacterial-type flagellum-dependent swarming motility
LCG53_09740	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LCG53_09745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LCG53_09745	COG0047	phosphoribosylformylglycinamidine synthase activity
LCG53_09750	COG1007	ATP synthesis coupled electron transport
LCG53_09755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCG53_09765	COG0713	ATP synthesis coupled electron transport
LCG53_09770	COG0839	Belongs to the complex I subunit 6 family
LCG53_09775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCG53_09780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LCG53_09785	COG1034	ATP synthesis coupled electron transport
LCG53_09800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCG53_09800	COG0649	NAD binding
LCG53_09805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCG53_09810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCG53_09815	COG1360	Flagellar Motor Protein
LCG53_09820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCG53_09835	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LCG53_09845	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LCG53_09855	COG0724	RNA recognition motif
LCG53_09860	COG4989	oxidoreductase activity
LCG53_09885	COG0745	RESPONSE REGULATOR receiver
LCG53_09890	COG0583	DNA-binding transcription factor activity
LCG53_09900	COG3300	MHYT domain
LCG53_09900	COG5001	Diguanylate cyclase
LCG53_09905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LCG53_09935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCG53_09940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LCG53_09945	COG0539	negative regulation of cytoplasmic translation
LCG53_09950	COG0776	regulation of translation
LCG53_09960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LCG53_09980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LCG53_09985	COG0602	queuosine metabolic process
LCG53_09990	COG3530	Putative quorum-sensing-regulated virulence factor
LCG53_09995	COG2096	Adenosyltransferase
LCG53_10000	COG2916	Histone family protein nucleoid-structuring protein H-NS
LCG53_10005	COG1757	Na H antiporter
LCG53_10010	COG1435	thymidine kinase activity
LCG53_10030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LCG53_10045	COG1349	DNA-binding transcription factor activity
LCG53_10050	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LCG53_10070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LCG53_10075	COG0626	cystathionine gamma-synthase activity
LCG53_10085	COG2910	NAD(P)H-binding
LCG53_10090	COG0583	DNA-binding transcription factor activity
LCG53_10095	COG1917	Cupin 2, conserved barrel domain protein
LCG53_10095	COG4977	sequence-specific DNA binding
LCG53_10100	COG2200	EAL domain
LCG53_10105	COG3706	GGDEF domain
LCG53_10110	COG4774	siderophore transport
LCG53_10120	COG0583	DNA-binding transcription factor activity
LCG53_10125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LCG53_10135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LCG53_10135	COG0617	tRNA 3'-terminal CCA addition
LCG53_10135	COG0517	IMP dehydrogenase activity
LCG53_10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCG53_10145	COG3046	protein related to deoxyribodipyrimidine photolyase
LCG53_10160	COG3088	subunit of a heme lyase
LCG53_10160	COG4235	cytochrome complex assembly
LCG53_10165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCG53_10170	COG1138	Cytochrome C-type biogenesis protein
LCG53_10175	COG3301	Polysulphide reductase, NrfD
LCG53_10180	COG0437	4 iron, 4 sulfur cluster binding
LCG53_10185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LCG53_10205	COG0247	lactate metabolic process
LCG53_10215	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LCG53_10220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LCG53_10225	COG3012	SEC-C Motif Domain Protein
LCG53_10230	COG0840	transmembrane signaling receptor activity
LCG53_10235	COG1940	carbohydrate kinase activity
LCG53_10235	COG1846	Transcriptional regulator
LCG53_10240	COG3290	protein histidine kinase activity
LCG53_10245	COG4565	transcriptional regulatory protein
LCG53_10260	COG3181	Tripartite tricarboxylate transporter family receptor
LCG53_10265	COG0739	heme binding
LCG53_10265	COG0741	lytic transglycosylase activity
LCG53_10265	COG1196	nuclear chromosome segregation
LCG53_10270	COG0569	domain protein
LCG53_10270	COG2985	domain, Protein
LCG53_10280	COG0556	nucleotide-excision repair
LCG53_10290	COG0586	Pfam SNARE associated Golgi protein
LCG53_10295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LCG53_10300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LCG53_10305	COG2186	Transcriptional regulator
LCG53_10310	COG2719	SpoVR family
LCG53_10315	COG2718	Belongs to the UPF0229 family
LCG53_10320	COG2766	serine protein kinase
LCG53_10325	COG0514	ATP-dependent DNA helicase (RecQ)
LCG53_10330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LCG53_10335	COG0814	amino acid
LCG53_10365	COG0058	SHG alpha-glucan phosphorylase activity
LCG53_10375	COG0471	metal ion transport
LCG53_10380	COG3118	belongs to the thioredoxin family
LCG53_10390	COG1132	(ABC) transporter
LCG53_10395	COG1132	(ABC) transporter
LCG53_10415	COG2501	S4 domain
LCG53_10425	COG3243	poly(R)-hydroxyalkanoic acid synthase
LCG53_10445	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LCG53_10450	COG2329	Antibiotic biosynthesis monooxygenase
LCG53_10485	COG0513	Belongs to the DEAD box helicase family
LCG53_10490	COG0386	Belongs to the glutathione peroxidase family
LCG53_10500	COG1181	Belongs to the D-alanine--D-alanine ligase family
LCG53_10505	COG3148	PFAM DTW domain containing protein
LCG53_10520	COG0730	response to heat
LCG53_10525	COG0583	DNA-binding transcription factor activity
LCG53_10540	COG3593	DNA synthesis involved in DNA repair
LCG53_10580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LCG53_10585	COG1011	Hydrolase
LCG53_10590	COG1473	amidohydrolase
LCG53_10595	COG0205	6-phosphofructokinase activity
LCG53_10605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LCG53_10610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCG53_10620	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LCG53_10625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LCG53_10655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LCG53_10660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCG53_10675	COG0588	phosphoglycerate mutase activity
LCG53_10690	COG1280	lysine exporter protein (LysE YggA)
LCG53_10700	COG2824	Alkylphosphonate utilization operon protein PhnA
LCG53_10735	COG2840	Smr protein MutS2
LCG53_10740	COG2890	protein-(glutamine-N5) methyltransferase activity
LCG53_10745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LCG53_10755	COG0513	Belongs to the DEAD box helicase family
LCG53_10760	COG5654	RES domain protein
LCG53_10770	COG0814	amino acid
LCG53_10775	COG1609	Transcriptional regulator
LCG53_10780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_10780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_10785	COG1105	Belongs to the carbohydrate kinase PfkB family
LCG53_10790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCG53_10790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCG53_10790	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LCG53_10795	COG3313	Fe-S protein
LCG53_10800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LCG53_10805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LCG53_10810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCG53_10815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCG53_10825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCG53_10900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LCG53_10905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LCG53_10910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LCG53_10915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LCG53_10920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LCG53_10925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCG53_10925	COG0072	phenylalanine-tRNA ligase activity
LCG53_10930	COG0776	regulation of translation
LCG53_10960	COG3300	MHYT domain
LCG53_10960	COG5001	Diguanylate cyclase
LCG53_10965	COG1609	Transcriptional regulator
LCG53_10970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCG53_10975	COG1879	ABC-type sugar transport system periplasmic component
LCG53_10980	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCG53_10985	COG1129	ABC transporter
LCG53_10990	COG1869	D-ribose catabolic process
LCG53_10995	COG0625	glutathione transferase activity
LCG53_11010	COG0037	tRNA processing
LCG53_11015	COG0589	response to stress
LCG53_11020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCG53_11035	COG2217	Heavy metal translocating P-type atpase
LCG53_11045	COG2010	Cytochrome c
LCG53_11060	COG3278	Belongs to the heme-copper respiratory oxidase family
LCG53_11070	COG1956	GAF domain-containing protein
LCG53_11075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LCG53_11085	COG0308	aminopeptidase N
LCG53_11095	COG2902	Dehydrogenase
LCG53_11100	COG0167	dihydroorotate dehydrogenase activity
LCG53_11110	COG0116	Belongs to the methyltransferase superfamily
LCG53_11110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LCG53_11120	COG0488	(ABC) transporter
LCG53_11135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LCG53_11140	COG1067	ATP-dependent peptidase activity
LCG53_11150	COG3141	response to X-ray
LCG53_11160	COG2995	paraquat-inducible protein a
LCG53_11165	COG3008	intermembrane lipid transfer
LCG53_11170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCG53_11170	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LCG53_11185	COG2801	Transposase and inactivated derivatives
LCG53_11210	COG0084	hydrolase, TatD family'
LCG53_11215	COG0470	DNA polymerase III
LCG53_11220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LCG53_11225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LCG53_11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCG53_11235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LCG53_11240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LCG53_11245	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_11255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCG53_11260	COG0416	fatty acid biosynthetic process
LCG53_11265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LCG53_11270	COG1399	metal-binding, possibly nucleic acid-binding protein
LCG53_11285	COG0564	pseudouridine synthase activity
LCG53_11290	COG1530	ribonuclease E activity
LCG53_11295	COG0306	phosphate transporter
LCG53_11300	COG0717	Belongs to the dCTP deaminase family
LCG53_11305	COG0572	uridine kinase
LCG53_11310	COG0489	protein tyrosine kinase activity
LCG53_11315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCG53_11315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCG53_11320	COG0625	glutathione transferase activity
LCG53_11325	COG1254	Belongs to the acylphosphatase family
LCG53_11330	COG0840	transmembrane signaling receptor activity
LCG53_11335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LCG53_11350	COG0709	Synthesizes selenophosphate from selenide and ATP
LCG53_11355	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LCG53_11360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCG53_11365	COG3437	response regulator, receiver
LCG53_11375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LCG53_11385	COG1643	Atp-dependent helicase
LCG53_11390	COG0517	IMP dehydrogenase activity
LCG53_11390	COG0617	tRNA 3'-terminal CCA addition
LCG53_11390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LCG53_11395	COG2197	response regulator
LCG53_11400	COG3314	Sporulation integral membrane protein YlbJ
LCG53_11410	COG0583	DNA-binding transcription factor activity
LCG53_11415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LCG53_11425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LCG53_11430	COG2832	Protein of unknown function (DUF454)
LCG53_11435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCG53_11445	COG0697	spore germination
LCG53_11460	COG0318	PFAM AMP-dependent synthetase and ligase
LCG53_11465	COG0596	Alpha beta hydrolase
LCG53_11475	COG1214	PFAM Peptidase M22, glycoprotease
LCG53_11480	COG1199	ATP-dependent helicase activity
LCG53_11490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LCG53_11495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LCG53_11500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LCG53_11505	COG0131	Imidazoleglycerol-phosphate dehydratase
LCG53_11505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LCG53_11510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LCG53_11515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LCG53_11520	COG3437	response regulator, receiver
LCG53_11530	COG0784	Response regulator, receiver
LCG53_11530	COG2198	Histidine kinase
LCG53_11530	COG2205	protein histidine kinase activity
LCG53_11535	COG0107	imidazoleglycerol-phosphate synthase activity
LCG53_11540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LCG53_11540	COG0140	phosphoribosyl-ATP diphosphatase activity
LCG53_11550	COG2378	regulation of single-species biofilm formation
LCG53_11555	COG0318	PFAM AMP-dependent synthetase and ligase
LCG53_11560	COG3134	Outer membrane lipoprotein
LCG53_11575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCG53_11600	COG4681	YaeQ
LCG53_11610	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCG53_11610	COG1024	Enoyl-CoA hydratase
LCG53_11615	COG0183	Belongs to the thiolase family
LCG53_11620	COG0714	Associated with various cellular activities
LCG53_11650	COG1595	DNA-templated transcription, initiation
LCG53_11660	COG2067	long-chain fatty acid transport protein
LCG53_11665	COG2067	long-chain fatty acid transport protein
LCG53_11670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LCG53_11685	COG1301	dicarboxylic acid transport
LCG53_11690	COG3123	guanosine phosphorylase activity
LCG53_11695	COG1760	l-serine dehydratase
LCG53_11700	COG1760	l-serine dehydratase
LCG53_11705	COG2951	lytic endotransglycosylase activity
LCG53_11710	COG3100	YcgL domain-containing protein
LCG53_11715	COG0850	regulation of cytokinetic process
LCG53_11720	COG2894	cell division
LCG53_11725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LCG53_11730	COG3099	Belongs to the UPF0263 family
LCG53_11735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCG53_11750	COG2996	Protein conserved in bacteria
LCG53_11775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LCG53_11780	COG0697	spore germination
LCG53_11785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LCG53_11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCG53_11805	COG0307	riboflavin synthase, alpha
LCG53_11815	COG0534	Mate efflux family protein
LCG53_11845	COG0417	DNA replication proofreading
LCG53_11860	COG1560	Kdo2-lipid A biosynthetic process
LCG53_11865	COG1560	Kdo2-lipid A biosynthetic process
LCG53_11875	COG0583	DNA-binding transcription factor activity
LCG53_11880	COG0673	inositol 2-dehydrogenase activity
LCG53_11885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LCG53_11905	COG0583	DNA-binding transcription factor activity
LCG53_11915	COG2723	6-phospho-beta-galactosidase activity
LCG53_11920	COG0583	DNA-binding transcription factor activity
LCG53_11930	COG0243	molybdopterin cofactor binding
LCG53_11935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LCG53_11950	COG0583	DNA-binding transcription factor activity
LCG53_11955	COG1879	ABC-type sugar transport system periplasmic component
LCG53_11960	COG1129	ABC transporter
LCG53_11965	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCG53_11970	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCG53_11985	COG0702	epimerase
LCG53_11990	COG1073	alpha beta
LCG53_11995	COG1073	alpha beta
LCG53_12045	COG0730	response to heat
LCG53_12055	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_12065	COG1024	Enoyl-CoA hydratase
LCG53_12070	COG1024	Enoyl-CoA hydratase
LCG53_12075	COG1960	acyl-CoA dehydrogenase activity
LCG53_12085	COG1960	acyl-CoA dehydrogenase activity
LCG53_12090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LCG53_12095	COG1024	Enoyl-CoA hydratase
LCG53_12120	COG1584	GPR1 FUN34 yaaH family protein
LCG53_12125	COG3228	Belongs to the MtfA family
LCG53_12135	COG1115	amino acid carrier protein
LCG53_12140	COG1024	Enoyl-CoA hydratase
LCG53_12155	COG3162	membrane
LCG53_12160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCG53_12165	COG0488	(ABC) transporter
LCG53_12170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCG53_12175	COG0776	regulation of translation
LCG53_12180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LCG53_12185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LCG53_12190	COG0740	serine-type endopeptidase activity
LCG53_12195	COG0544	peptidyl-prolyl cis-trans isomerase activity
LCG53_12205	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LCG53_12210	COG4591	ABC-type transport system involved in lipoprotein release permease component
LCG53_12215	COG1136	(ABC) transporter
LCG53_12220	COG4591	ABC-type transport system involved in lipoprotein release permease component
LCG53_12230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LCG53_12235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LCG53_12260	COG2062	phosphohistidine phosphatase, SixA
LCG53_12270	COG0500	methyltransferase
LCG53_12280	COG1846	Transcriptional regulator
LCG53_12345	COG0789	Transcriptional regulator
LCG53_12420	COG0582	viral genome integration into host DNA
LCG53_12425	COG0519	Catalyzes the synthesis of GMP from XMP
LCG53_12425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCG53_12430	COG0517	IMP dehydrogenase activity
LCG53_12430	COG0516	GMP reductase activity
LCG53_12440	COG0366	Alpha amylase catalytic
LCG53_12440	COG1874	Beta-galactosidase
LCG53_12450	COG1570	exodeoxyribonuclease VII activity
LCG53_12460	COG2885	chlorophyll binding
LCG53_12480	COG2154	pterin-4-alpha-carbinolamine dehydratase
LCG53_12490	COG3768	UPF0283 membrane protein
LCG53_12495	COG3106	COG3106 Predicted ATPase
LCG53_12510	COG1842	Phage shock protein A
LCG53_12515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LCG53_12530	COG4171	peptide transport system, permease
LCG53_12540	COG4172	Belongs to the ABC transporter superfamily
LCG53_12550	COG1609	Transcriptional regulator
LCG53_12555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_12555	COG1263	PTS System
LCG53_12560	COG2723	6-phospho-beta-galactosidase activity
LCG53_12565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LCG53_12570	COG1286	toxin biosynthetic process
LCG53_12575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LCG53_12580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LCG53_12585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LCG53_12590	COG0531	amino acid
LCG53_12590	COG1674	ftsk spoiiie
LCG53_12600	COG0686	Belongs to the AlaDH PNT family
LCG53_12605	COG0492	ferredoxin-NADP+ reductase activity
LCG53_12610	COG3706	GGDEF domain
LCG53_12615	COG3134	Outer membrane lipoprotein
LCG53_12620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LCG53_12625	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LCG53_12630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LCG53_12635	COG0542	response to heat
LCG53_12640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LCG53_12645	COG1278	Cold shock
LCG53_12650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LCG53_12665	COG1944	ATP diphosphatase activity
LCG53_12670	COG2116	formate transmembrane transporter activity
LCG53_12675	COG1882	Formate acetyltransferase
LCG53_12680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCG53_12685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCG53_12690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LCG53_12700	COG1840	ABC-type Fe3 transport system, periplasmic component
LCG53_12705	COG3842	ATPase activity
LCG53_12715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCG53_12720	COG2983	Belongs to the UPF0260 family
LCG53_12730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LCG53_12735	COG0045	succinate-CoA ligase (ADP-forming) activity
LCG53_12740	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCG53_12745	COG0567	Dehydrogenase, E1 component
LCG53_12760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LCG53_12765	COG2009	succinate dehydrogenase
LCG53_12785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LCG53_12790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCG53_12790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LCG53_12800	COG3069	C4-dicarboxylate transmembrane transporter activity
LCG53_12815	COG1451	nucleotide metabolic process
LCG53_12830	COG0254	rRNA binding
LCG53_12835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LCG53_12845	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCG53_12850	COG1129	ABC transporter
LCG53_12855	COG1879	ABC-type sugar transport system periplasmic component
LCG53_12860	COG1069	ribulokinase activity
LCG53_12870	COG2160	L-arabinose isomerase activity
LCG53_12875	COG0583	DNA-binding transcription factor activity
LCG53_12880	COG0436	Aminotransferase
LCG53_12885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCG53_12900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LCG53_12900	COG0392	lysyltransferase activity
LCG53_12925	COG1263	PTS System
LCG53_12925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_12930	COG1874	Beta-galactosidase
LCG53_12935	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LCG53_12940	COG3833	ABC-type maltose transport systems, permease component
LCG53_12945	COG1175	transmembrane transport
LCG53_12950	COG2182	Extracellular solute-binding protein
LCG53_12975	COG4580	involved in the transport of maltose and maltodextrins
LCG53_12980	COG1609	Transcriptional regulator
LCG53_12985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCG53_12990	COG1085	galactose-1-phosphate uridylyltransferase
LCG53_12995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LCG53_13025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LCG53_13060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LCG53_13080	COG2925	Exonuclease
LCG53_13090	COG3345	alpha-galactosidase
LCG53_13095	COG1380	Effector of murein hydrolase LrgA
LCG53_13100	COG1346	cytolysis
LCG53_13105	COG0295	cytidine deaminase activity
LCG53_13110	COG1022	Amp-dependent synthetase and ligase
LCG53_13125	COG0861	Integral membrane protein TerC family
LCG53_13130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCG53_13135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LCG53_13140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LCG53_13180	COG4771	TonB-dependent receptor
LCG53_13185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCG53_13190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCG53_13195	COG1120	ATPase activity
LCG53_13210	COG0300	oxidoreductase activity
LCG53_13210	COG0318	PFAM AMP-dependent synthetase and ligase
LCG53_13210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LCG53_13210	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_13210	COG3321	synthase
LCG53_13220	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_13225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LCG53_13230	COG3433	isochorismatase activity
LCG53_13230	COG1535	isochorismatase
LCG53_13235	COG1021	2,3-dihydroxybenzoate-AMP ligase
LCG53_13260	COG3300	MHYT domain
LCG53_13260	COG5001	Diguanylate cyclase
LCG53_13275	COG0840	transmembrane signaling receptor activity
LCG53_13280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCG53_13285	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LCG53_13290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LCG53_13295	COG0563	adenylate kinase activity
LCG53_13300	COG0326	Molecular chaperone. Has ATPase activity
LCG53_13305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LCG53_13310	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LCG53_13315	COG0298	carbon dioxide binding
LCG53_13325	COG0309	Hydrogenase expression formation protein (HypE)
LCG53_13330	COG0375	protein maturation
LCG53_13340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LCG53_13345	COG1124	(ABC) transporter
LCG53_13350	COG0444	Belongs to the ABC transporter superfamily
LCG53_13355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCG53_13370	COG1773	rubredoxin
LCG53_13375	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LCG53_13380	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LCG53_13385	COG5557	Pfam Polysulphide reductase, NrfD
LCG53_13390	COG0437	4 iron, 4 sulfur cluster binding
LCG53_13395	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LCG53_13400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCG53_13410	COG0659	secondary active sulfate transmembrane transporter activity
LCG53_13430	COG2308	Evidence 4 Homologs of previously reported genes of
LCG53_13465	COG0672	)-iron permease
LCG53_13490	COG2814	Major facilitator Superfamily
LCG53_13510	COG1136	(ABC) transporter
LCG53_13515	COG0577	efflux transmembrane transporter activity
LCG53_13545	COG1139	Iron-sulfur cluster binding protein
LCG53_13550	COG0247	lactate metabolic process
LCG53_13555	COG1620	l-lactate permease
LCG53_13560	COG0583	DNA-binding transcription factor activity
LCG53_13585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCG53_13590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LCG53_13590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LCG53_13595	COG0527	aspartate kinase activity
LCG53_13605	COG1368	sulfuric ester hydrolase activity
LCG53_13610	COG0393	Putative heavy-metal-binding
LCG53_13620	COG1252	NADH dehydrogenase
LCG53_13625	COG3150	esterase
LCG53_13630	COG1164	Oligoendopeptidase f
LCG53_13635	COG1164	Oligoendopeptidase f
LCG53_13640	COG2354	Protein conserved in bacteria
LCG53_13655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCG53_13660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCG53_13695	COG0537	adenosine 5'-monophosphoramidase activity
LCG53_13710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LCG53_13730	COG1301	dicarboxylic acid transport
LCG53_13740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCG53_13745	COG0861	Integral membrane protein TerC family
LCG53_13755	COG0444	Belongs to the ABC transporter superfamily
LCG53_13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCG53_13765	COG0601	transmembrane transport
LCG53_13775	COG2095	MarC family integral membrane protein
LCG53_13780	COG1012	belongs to the aldehyde dehydrogenase family
LCG53_13780	COG1454	alcohol dehydrogenase
LCG53_13790	COG3275	phosphorelay sensor kinase activity
LCG53_13795	COG3279	Response regulator of the LytR AlgR family
LCG53_13800	COG1966	Carbon starvation protein
LCG53_13805	COG3264	Mechanosensitive ion channel
LCG53_13805	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LCG53_13815	COG1566	PFAM secretion protein HlyD family protein
LCG53_13820	COG1061	Type III restriction enzyme res subunit
LCG53_13825	COG2027	D-alanyl-D-alanine carboxypeptidase
LCG53_13830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LCG53_13840	COG0436	Aminotransferase
LCG53_13845	COG1288	antiporter activity
LCG53_13850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LCG53_13875	COG0697	spore germination
LCG53_13880	COG4657	Part of a membrane complex involved in electron transport
LCG53_13885	COG2878	Part of a membrane complex involved in electron transport
LCG53_13895	COG4658	electron transport chain
LCG53_13900	COG4659	FMN binding
LCG53_13905	COG4660	Part of a membrane complex involved in electron transport
LCG53_13910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LCG53_13915	COG0346	lactoylglutathione lyase activity
LCG53_13940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LCG53_13950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCG53_13955	COG1086	Polysaccharide biosynthesis protein
LCG53_13960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LCG53_13970	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
LCG53_13975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCG53_13990	COG2089	acid synthase
LCG53_14030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LCG53_14050	COG0301	tRNA thio-modification
LCG53_14050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCG53_14060	COG4953	penicillin-binding protein 1C
LCG53_14065	COG2373	Large extracellular alpha-helical protein
LCG53_14070	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCG53_14080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LCG53_14090	COG4160	amino acid transport
LCG53_14100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_14110	COG2431	L-lysine efflux transmembrane transporter activity
LCG53_14115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LCG53_14120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_14145	COG1393	Belongs to the ArsC family
LCG53_14155	COG4783	chaperone-mediated protein folding
LCG53_14160	COG0425	Belongs to the sulfur carrier protein TusA family
LCG53_14175	COG0596	Alpha beta hydrolase
LCG53_14185	COG3842	ATPase activity
LCG53_14190	COG3833	ABC-type maltose transport systems, permease component
LCG53_14195	COG1175	transmembrane transport
LCG53_14205	COG3081	Nucleoid-associated protein
LCG53_14210	COG3082	Protein of unknown function (DUF1414)
LCG53_14215	COG3083	sulfuric ester hydrolase activity
LCG53_14220	COG4771	TonB-dependent receptor
LCG53_14225	COG1770	oligopeptidase
LCG53_14245	COG4574	serine-type endopeptidase inhibitor activity
LCG53_14250	COG3085	chromosome segregation
LCG53_14260	COG0287	Prephenate dehydrogenase
LCG53_14260	COG1605	Chorismate mutase
LCG53_14265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCG53_14270	COG0584	glycerophosphoryl diester phosphodiesterase
LCG53_14280	COG1349	DNA-binding transcription factor activity
LCG53_14285	COG2271	Major facilitator Superfamily
LCG53_14290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LCG53_14295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LCG53_14300	COG0583	DNA-binding transcription factor activity
LCG53_14320	COG0656	L-ascorbic acid biosynthetic process
LCG53_14325	COG2814	Major facilitator Superfamily
LCG53_14345	COG1294	oxidase, subunit
LCG53_14355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCG53_14365	COG2979	Protein of unknown function (DUF533)
LCG53_14385	COG0583	DNA-binding transcription factor activity
LCG53_14395	COG2807	transmembrane transport
LCG53_14400	COG1187	pseudouridine synthase activity
LCG53_14405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LCG53_14425	COG1061	Type III restriction enzyme res subunit
LCG53_14450	COG1166	arginine decarboxylase activity
LCG53_14455	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCG53_14470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LCG53_14485	COG0583	DNA-binding transcription factor activity
LCG53_14495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LCG53_14500	COG0840	transmembrane signaling receptor activity
LCG53_14505	COG0302	gtp cyclohydrolase
LCG53_14515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCG53_14530	COG2267	carboxylic ester hydrolase activity
LCG53_14535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LCG53_14550	COG0314	molybdopterin synthase activity
LCG53_14555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LCG53_14560	COG0315	cyclic pyranopterin monophosphate synthase activity
LCG53_14565	COG0521	Mo-molybdopterin cofactor biosynthetic process
LCG53_14570	COG3005	denitrification pathway
LCG53_14580	COG0348	domain, Protein
LCG53_14585	COG0437	4 iron, 4 sulfur cluster binding
LCG53_14590	COG0243	molybdopterin cofactor binding
LCG53_14600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCG53_14600	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCG53_14605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LCG53_14610	COG3850	Histidine kinase
LCG53_14615	COG2197	response regulator
LCG53_14640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LCG53_14650	COG0121	glutamine amidotransferase
LCG53_14655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LCG53_14660	COG1960	acyl-CoA dehydrogenase activity
LCG53_14665	COG0784	Response regulator, receiver
LCG53_14665	COG3437	response regulator, receiver
LCG53_14675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCG53_14680	COG0328	RNA-DNA hybrid ribonuclease activity
LCG53_14685	COG2226	methyltransferase
LCG53_14690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCG53_14700	COG0741	lytic transglycosylase activity
LCG53_14700	COG1388	LysM domain
LCG53_14715	COG1607	acyl-coa hydrolase
LCG53_14730	COG0741	lytic transglycosylase activity
LCG53_14740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LCG53_14765	COG2911	Protein conserved in bacteria
LCG53_14770	COG0729	surface antigen
LCG53_14780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCG53_14790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCG53_14795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCG53_14800	COG4134	Bacterial extracellular solute-binding protein
LCG53_14810	COG4136	ATPase activity
LCG53_14815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LCG53_14820	COG2951	lytic endotransglycosylase activity
LCG53_14825	COG1846	Transcriptional regulator
LCG53_14835	COG0033	Phosphoglucomutase
LCG53_14840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LCG53_14845	COG0596	Alpha beta hydrolase
LCG53_14860	COG0716	FMN binding
LCG53_14870	COG0735	belongs to the Fur family
LCG53_14875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCG53_14885	COG2190	(PTS) system
LCG53_14885	COG1263	PTS System
LCG53_14885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_14890	COG0363	glucosamine-6-phosphate deaminase activity
LCG53_14895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LCG53_14900	COG1846	Transcriptional regulator
LCG53_14900	COG1940	carbohydrate kinase activity
LCG53_14905	COG2194	sulfuric ester hydrolase activity
LCG53_14910	COG0217	transcriptional regulatory protein
LCG53_14915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LCG53_14920	COG1801	Protein of unknown function DUF72
LCG53_14925	COG4106	trans-aconitate 2-methyltransferase activity
LCG53_14930	COG0500	methyltransferase
LCG53_14950	COG0583	DNA-binding transcription factor activity
LCG53_14955	COG0791	NLP P60 protein
LCG53_14970	COG1309	transcriptional regulator
LCG53_14980	COG1454	alcohol dehydrogenase
LCG53_15005	COG0534	Mate efflux family protein
LCG53_15015	COG2841	Protein conserved in bacteria
LCG53_15035	COG0674	pyruvate-flavodoxin oxidoreductase activity
LCG53_15035	COG1013	pyruvate-flavodoxin oxidoreductase activity
LCG53_15035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LCG53_15035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LCG53_15045	COG0633	Ferredoxin
LCG53_15045	COG0633	Ferredoxin
LCG53_15045	COG3217	Mosc domain protein beta barrel domain protein
LCG53_15045	COG3217	Mosc domain protein beta barrel domain protein
LCG53_15050	COG0501	Belongs to the peptidase M48B family
LCG53_15055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LCG53_15060	COG2226	methyltransferase
LCG53_15060	COG1073	alpha beta
LCG53_15065	COG0156	8-amino-7-oxononanoate synthase activity
LCG53_15070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LCG53_15090	COG0017	Asparaginyl-tRNA synthetase
LCG53_15095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LCG53_15105	COG1473	amidohydrolase
LCG53_15110	COG3069	C4-dicarboxylate transmembrane transporter activity
LCG53_15120	COG1393	Belongs to the ArsC family
LCG53_15125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCG53_15130	COG1876	peptidase activity
LCG53_15140	COG3263	regulation of cellular component size
LCG53_15150	COG1280	lysine exporter protein (LysE YggA)
LCG53_15180	COG1957	nucleoside hydrolase
LCG53_15185	COG0564	pseudouridine synthase activity
LCG53_15195	COG1454	alcohol dehydrogenase
LCG53_15200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCG53_15205	COG0702	epimerase
LCG53_15210	COG2914	Belongs to the UPF0125 (RnfH) family
LCG53_15215	COG2867	negative regulation of translational initiation
LCG53_15220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LCG53_15235	COG0800	Aldolase
LCG53_15250	COG3153	acetyltransferase
LCG53_15280	COG0259	pyridoxamine-phosphate oxidase activity
LCG53_15295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCG53_15295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCG53_15300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LCG53_15325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCG53_15330	COG1138	Cytochrome C-type biogenesis protein
LCG53_15335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LCG53_15340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCG53_15345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCG53_15350	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCG53_15365	COG0835	chemotaxis
LCG53_15375	COG1192	Involved in chromosome partitioning
LCG53_15380	COG1360	Flagellar Motor Protein
LCG53_15385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCG53_15390	COG2201	protein-glutamate methylesterase activity
LCG53_15395	COG0643	Histidine kinase
LCG53_15395	COG0784	Response regulator, receiver
LCG53_15395	COG2198	Histidine kinase
LCG53_15400	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LCG53_15425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LCG53_15435	COG1684	flagellar biosynthetic protein fliR
LCG53_15490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCG53_15500	COG1677	Flagellar hook-basal body complex protein FliE
LCG53_15515	COG1393	Belongs to the ArsC family
LCG53_15520	COG0798	PFAM Bile acid sodium symporter
LCG53_15525	COG0640	Transcriptional regulator
LCG53_15535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCG53_15550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCG53_15555	COG0444	Belongs to the ABC transporter superfamily
LCG53_15560	COG4608	Belongs to the ABC transporter superfamily
LCG53_15570	COG2971	BadF BadG BcrA BcrD
LCG53_15580	COG0840	transmembrane signaling receptor activity
LCG53_15600	COG3724	N-succinylarginine dihydrolase activity
LCG53_15605	COG0616	signal peptide processing
LCG53_15610	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_15615	COG0583	DNA-binding transcription factor activity
LCG53_15625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LCG53_15635	COG0583	DNA-binding transcription factor activity
LCG53_15640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LCG53_15645	COG1881	PFAM PEBP family protein
LCG53_15655	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LCG53_15655	COG3408	Glycogen debranching enzyme
LCG53_15660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LCG53_15665	COG0739	heme binding
LCG53_15670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LCG53_15695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LCG53_15705	COG3091	SprT-like family
LCG53_15715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LCG53_15720	COG0189	ligase activity
LCG53_15730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LCG53_15750	COG1115	amino acid carrier protein
LCG53_15755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LCG53_15770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LCG53_15780	COG1301	dicarboxylic acid transport
LCG53_15785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LCG53_15790	COG2912	Transglutaminase-like superfamily
LCG53_15800	COG2890	protein-(glutamine-N5) methyltransferase activity
LCG53_15805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LCG53_15810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LCG53_15815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LCG53_15820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LCG53_15830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LCG53_15835	COG0193	aminoacyl-tRNA hydrolase activity
LCG53_15840	COG0012	GTP binding
LCG53_15885	COG0471	metal ion transport
LCG53_15885	COG0490	domain, Protein
LCG53_15910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCG53_15955	COG1012	belongs to the aldehyde dehydrogenase family
LCG53_15965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LCG53_15980	COG0180	Tryptophanyl-tRNA synthetase
LCG53_15985	COG0546	phosphoglycolate phosphatase activity
LCG53_15990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LCG53_15995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LCG53_16005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LCG53_16010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LCG53_16040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LCG53_16045	COG0583	DNA-binding transcription factor activity
LCG53_16060	COG0583	DNA-binding transcription factor activity
LCG53_16070	COG0739	heme binding
LCG53_16080	COG1511	domain protein
LCG53_16080	COG3264	Mechanosensitive ion channel
LCG53_16085	COG0584	glycerophosphoryl diester phosphodiesterase
LCG53_16095	COG1053	succinate dehydrogenase
LCG53_16100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LCG53_16105	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LCG53_16110	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LCG53_16125	COG3214	Protein conserved in bacteria
LCG53_16130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCG53_16150	COG0300	oxidoreductase activity
LCG53_16170	COG0189	ligase activity
LCG53_16170	COG4067	protein conserved in archaea
LCG53_16175	COG0516	GMP reductase activity
LCG53_16185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LCG53_16190	COG2011	ABC-type metal ion transport system permease component
LCG53_16200	COG1464	Belongs to the NlpA lipoprotein family
LCG53_16215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCG53_16225	COG2199	diguanylate cyclase activity
LCG53_16235	COG2199	diguanylate cyclase activity
LCG53_16240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCG53_16255	COG1335	isochorismatase
LCG53_16260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCG53_16265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCG53_16270	COG1702	phosphate starvation-inducible protein PhoH
LCG53_16275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LCG53_16280	COG4535	Mg2 and Co2 transporter CorC
LCG53_16285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LCG53_16290	COG2888	peptidyl-tyrosine sulfation
LCG53_16295	COG0495	leucyl-tRNA aminoacylation
LCG53_16310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LCG53_16315	COG0799	negative regulation of ribosome biogenesis
LCG53_16320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LCG53_16325	COG0768	penicillin binding
LCG53_16330	COG0772	Belongs to the SEDS family
LCG53_16335	COG2951	lytic endotransglycosylase activity
LCG53_16340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LCG53_16345	COG1686	Belongs to the peptidase S11 family
LCG53_16350	COG2921	Belongs to the UPF0250 family
LCG53_16355	COG0321	lipoyl(octanoyl) transferase activity
LCG53_16360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LCG53_16370	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LCG53_16385	COG0789	Transcriptional regulator
LCG53_16390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LCG53_16400	COG1970	mechanosensitive ion channel activity
LCG53_16405	COG4974	Belongs to the 'phage' integrase family
LCG53_16415	COG0312	modulator of DNA gyrase
LCG53_16420	COG0312	modulator of DNA gyrase
LCG53_16435	COG0826	peptidase U32
LCG53_16440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCG53_16445	COG1422	Protein of unknown function (DUF1090)
LCG53_16450	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LCG53_16455	COG2211	Major facilitator Superfamily
LCG53_16460	COG1185	polyribonucleotide nucleotidyltransferase activity
LCG53_16465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LCG53_16470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LCG53_16475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LCG53_16480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LCG53_16485	COG0195	Participates in both transcription termination and antitermination
LCG53_16490	COG0779	Required for maturation of 30S ribosomal subunits
LCG53_16505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LCG53_16510	COG0149	triose-phosphate isomerase activity
LCG53_16515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LCG53_16520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LCG53_16530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LCG53_16535	COG1534	Rna-binding protein
LCG53_16550	COG1360	Flagellar Motor Protein
LCG53_16555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCG53_16560	COG1722	exodeoxyribonuclease VII activity
LCG53_16565	COG0142	geranyltranstransferase activity
LCG53_16570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LCG53_16575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCG53_16580	COG0601	transmembrane transport
LCG53_16590	COG4172	Belongs to the ABC transporter superfamily
LCG53_16595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LCG53_16600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LCG53_16605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCG53_16610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LCG53_16625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCG53_16625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCG53_16630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LCG53_16660	COG3550	peptidyl-serine autophosphorylation
LCG53_16690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LCG53_16700	COG3381	protein complex oligomerization
LCG53_16715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCG53_16720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LCG53_16725	COG0511	ligase activity, forming carbon-carbon bonds
LCG53_16730	COG0439	Biotin carboxylase
LCG53_16735	COG3924	membrane
LCG53_16740	COG4145	pantothenate transmembrane transporter activity
LCG53_16745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_16745	COG2190	(PTS) system
LCG53_16745	COG1263	PTS System
LCG53_16750	COG0583	DNA-binding transcription factor activity
LCG53_16755	COG0604	alcohol dehydrogenase
LCG53_16760	COG2264	protein methyltransferase activity
LCG53_16765	COG0110	maltose O-acetyltransferase activity
LCG53_16780	COG0778	Nitroreductase
LCG53_16785	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCG53_16785	COG1902	pentaerythritol trinitrate reductase activity
LCG53_16790	COG0616	signal peptide processing
LCG53_16810	COG3139	Protein of unknown function (DUF1315)
LCG53_16815	COG0252	asparaginase activity
LCG53_16820	COG0786	glutamate:sodium symporter activity
LCG53_16835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LCG53_16840	COG0384	phenazine biosynthesis protein PhzF
LCG53_16845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LCG53_16850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCG53_16855	COG0175	sulfate reduction
LCG53_16860	COG2113	Glycine betaine
LCG53_16865	COG4176	ABC-type proline glycine betaine transport system permease component
LCG53_16870	COG4175	Glycine betaine
LCG53_16880	COG3610	response to peptide
LCG53_16885	COG2966	Psort location CytoplasmicMembrane, score
LCG53_16895	COG0521	Mo-molybdopterin cofactor biosynthetic process
LCG53_16920	COG2313	pseudouridylate synthase activity
LCG53_16925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCG53_16930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCG53_16930	COG2146	nitrite reductase [NAD(P)H] activity
LCG53_16935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCG53_16935	COG2146	nitrite reductase [NAD(P)H] activity
LCG53_16940	COG1116	anion transmembrane transporter activity
LCG53_16945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCG53_16950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCG53_16950	COG1116	anion transmembrane transporter activity
LCG53_16960	COG1648	precorrin-2 dehydrogenase activity
LCG53_16960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCG53_16965	COG0243	molybdopterin cofactor binding
LCG53_16990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LCG53_17005	COG1073	alpha beta
LCG53_17010	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LCG53_17015	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCG53_17020	COG4608	Belongs to the ABC transporter superfamily
LCG53_17025	COG0444	Belongs to the ABC transporter superfamily
LCG53_17035	COG4239	(ABC) transporter, permease
LCG53_17040	COG4174	ABC transporter (Permease)
LCG53_17045	COG4206	TonB-dependent receptor
LCG53_17055	COG0811	peptide transport
LCG53_17060	COG0811	peptide transport
LCG53_17065	COG0848	biopolymer transport protein
LCG53_17115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCG53_17120	COG0840	transmembrane signaling receptor activity
LCG53_17130	COG1278	Cold shock
LCG53_17170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LCG53_17175	COG1162	GTPase activity
LCG53_17180	COG0688	phosphatidylethanolamine metabolic process
LCG53_17185	COG4628	conserved protein (DUF2132)
LCG53_17205	COG5001	Diguanylate cyclase
LCG53_17205	COG3300	MHYT domain
LCG53_17210	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LCG53_17235	COG1132	(ABC) transporter
LCG53_17245	COG2897	thiosulfate sulfurtransferase activity
LCG53_17250	COG2066	Belongs to the glutaminase family
LCG53_17255	COG3171	Protein conserved in bacteria
LCG53_17260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LCG53_17265	COG2234	aminopeptidase activity
LCG53_17265	COG4935	Belongs to the peptidase S8 family
LCG53_17270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCG53_17275	COG2200	EAL domain
LCG53_17280	COG1090	epimerase
LCG53_17285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LCG53_17290	COG4181	ATPase activity
LCG53_17295	COG2755	lipolytic protein G-D-S-L family
LCG53_17300	COG0835	chemotaxis
LCG53_17300	COG0784	Response regulator, receiver
LCG53_17310	COG0517	IMP dehydrogenase activity
LCG53_17310	COG0516	GMP reductase activity
LCG53_17315	COG0488	(ABC) transporter
LCG53_17325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LCG53_17375	COG0789	Transcriptional regulator
LCG53_17385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCG53_17395	COG0668	transmembrane transport
LCG53_17405	COG2731	YhcH YjgK YiaL family protein
LCG53_17415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCG53_17420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCG53_17425	COG3227	Zinc metalloprotease (Elastase)
LCG53_17430	COG0583	DNA-binding transcription factor activity
LCG53_17435	COG0477	Major facilitator Superfamily
LCG53_17445	COG2985	domain, Protein
LCG53_17445	COG0569	domain protein
LCG53_17450	COG1272	protein, Hemolysin III
LCG53_17455	COG0076	glutamate decarboxylase activity
LCG53_17460	COG2917	probably involved in intracellular septation
LCG53_17465	COG2350	Protein conserved in bacteria
LCG53_17475	COG1555	photosystem II stabilization
LCG53_17480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LCG53_17485	COG3104	oligopeptide transport
LCG53_17490	COG0745	RESPONSE REGULATOR receiver
LCG53_17520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_17535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LCG53_17560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCG53_17565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_17625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LCG53_17640	COG0732	type I restriction modification DNA specificity domain
LCG53_17645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LCG53_17695	COG2003	Belongs to the UPF0758 family
LCG53_17750	COG3311	Transcriptional regulator
LCG53_17765	COG1280	lysine exporter protein (LysE YggA)
LCG53_17790	COG0316	Belongs to the HesB IscA family
LCG53_17800	COG0038	chloride channel
LCG53_17805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCG53_17820	COG0671	phosphoesterase, PA-phosphatase related
LCG53_17830	COG0583	DNA-binding transcription factor activity
LCG53_17835	COG2076	Multidrug Resistance protein
LCG53_17845	COG0346	lactoylglutathione lyase activity
LCG53_17850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCG53_17855	COG1643	Atp-dependent helicase
LCG53_17865	COG1489	DNA binding
LCG53_17870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LCG53_17875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCG53_17885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LCG53_17890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LCG53_17895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LCG53_17905	COG0842	Transport permease protein
LCG53_17910	COG1131	(ABC) transporter
LCG53_17925	COG0163	prenyltransferase activity
LCG53_17930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCG53_17935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LCG53_17950	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LCG53_17965	COG1136	(ABC) transporter
LCG53_18015	COG2801	Transposase and inactivated derivatives
LCG53_18020	COG0529	Catalyzes the synthesis of activated sulfate
LCG53_18025	COG0471	metal ion transport
LCG53_18025	COG3273	potassium ion transport
LCG53_18030	COG2895	sulfate adenylyltransferase (ATP) activity
LCG53_18035	COG0175	sulfate reduction
LCG53_18040	COG1648	precorrin-2 dehydrogenase activity
LCG53_18040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCG53_18045	COG0330	HflC and HflK could
LCG53_18050	COG1585	Membrane protein implicated in regulation of membrane protease activity
LCG53_18060	COG0673	inositol 2-dehydrogenase activity
LCG53_18070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LCG53_18075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCG53_18080	COG3036	rescue of stalled ribosome
LCG53_18095	COG0138	bifunctional purine biosynthesis protein purh
LCG53_18130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LCG53_18135	COG0358	DNA primase activity
LCG53_18140	COG1610	YqeY-like protein
LCG53_18145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LCG53_18150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LCG53_18160	COG1388	LysM domain
LCG53_18160	COG4942	peptidase
LCG53_18165	COG1238	metal cluster binding
LCG53_18170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LCG53_18175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LCG53_18180	COG0585	pseudouridine synthase activity
LCG53_18190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LCG53_18195	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LCG53_18200	COG0148	phosphopyruvate hydratase activity
LCG53_18205	COG0504	CTP synthase activity
LCG53_18210	COG3956	TIGRFAM MazG family protein
LCG53_18215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCG53_18220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCG53_18230	COG4807	Protein conserved in bacteria
LCG53_18235	COG3023	N-Acetylmuramoyl-L-alanine amidase
LCG53_18240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LCG53_18245	COG1381	Involved in DNA repair and RecF pathway recombination
LCG53_18255	COG0571	ribonuclease III activity
LCG53_18260	COG0681	Belongs to the peptidase S26 family
LCG53_18265	COG0481	GTPase activity
LCG53_18280	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LCG53_18285	COG1595	DNA-templated transcription, initiation
LCG53_18290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LCG53_18300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LCG53_18310	COG0583	DNA-binding transcription factor activity
LCG53_18345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCG53_18355	COG0126	phosphoglycerate kinase activity
LCG53_18360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCG53_18365	COG1940	carbohydrate kinase activity
LCG53_18370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LCG53_18375	COG2816	NAD+ diphosphatase activity
LCG53_18380	COG4991	sh3 domain protein
LCG53_18385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCG53_18400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LCG53_18405	COG1028	Short-chain dehydrogenase reductase Sdr
LCG53_18415	COG1505	serine-type exopeptidase activity
LCG53_18420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LCG53_18425	COG0765	amino acid transport
LCG53_18430	COG0765	amino acid transport
LCG53_18435	COG1126	abc transporter atp-binding protein
LCG53_18440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCG53_18445	COG3174	membrane
LCG53_18450	COG0110	maltose O-acetyltransferase activity
LCG53_18490	COG0583	DNA-binding transcription factor activity
LCG53_18495	COG0165	Argininosuccinate lyase
LCG53_18500	COG0137	argininosuccinate synthase activity
LCG53_18510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LCG53_18515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LCG53_18525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LCG53_18535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LCG53_18570	COG0583	DNA-binding transcription factor activity
LCG53_18575	COG1380	Effector of murein hydrolase LrgA
LCG53_18580	COG1346	cytolysis
LCG53_18585	COG0527	aspartate kinase activity
LCG53_18585	COG0460	homoserine dehydrogenase
LCG53_18590	COG0626	cystathionine gamma-synthase activity
LCG53_18605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCG53_18610	COG0814	amino acid
LCG53_18615	COG1218	3'(2'),5'-bisphosphate nucleotidase
LCG53_18620	COG0494	nUDIX hydrolase
LCG53_18625	COG1011	Hydrolase
LCG53_18640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LCG53_18655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LCG53_18665	COG3156	type II secretion system protein K
LCG53_18675	COG4795	General secretion pathway protein
LCG53_18680	COG2165	general secretion pathway protein
LCG53_18690	COG2165	general secretion pathway protein
LCG53_18695	COG1459	type II secretion system
LCG53_18700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCG53_18710	COG3031	protein transport across the cell outer membrane
LCG53_18720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LCG53_18725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LCG53_18740	COG0456	acetyltransferase
LCG53_18745	COG3133	Outer membrane lipoprotein
LCG53_18755	COG3025	triphosphatase activity
LCG53_18760	COG1392	Phosphate transport regulator
LCG53_18765	COG0306	phosphate transporter
LCG53_18770	COG0617	tRNA 3'-terminal CCA addition
LCG53_18775	COG3409	Peptidoglycan-binding domain 1 protein
LCG53_18775	COG3267	Type II secretory pathway component ExeA
LCG53_18785	COG1194	a g-specific adenine glycosylase
LCG53_18790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LCG53_18805	COG3240	lipase activity
LCG53_18815	COG3009	Protein conserved in bacteria
LCG53_18820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LCG53_18820	COG3008	intermembrane lipid transfer
LCG53_18825	COG2995	paraquat-inducible protein a
LCG53_18835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCG53_18840	COG4251	negative regulation of phosphorylation
LCG53_18840	COG2203	Gaf domain
LCG53_18840	COG5001	Diguanylate cyclase
LCG53_18840	COG3706	GGDEF domain
LCG53_18845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCG53_18850	COG2813	Specifically methylates the guanine in position
LCG53_18855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LCG53_18860	COG0297	glycogen (starch) synthase activity
LCG53_18900	COG1757	Na H antiporter
LCG53_18905	COG0583	DNA-binding transcription factor activity
LCG53_18910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LCG53_18915	COG3842	ATPase activity
LCG53_18920	COG1176	ABC-type spermidine putrescine transport system, permease component I
LCG53_18925	COG1177	transmembrane transport
LCG53_18930	COG1012	belongs to the aldehyde dehydrogenase family
LCG53_18935	COG0109	protoheme IX farnesyltransferase activity
LCG53_18965	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LCG53_18975	COG1565	acr, cog1565
LCG53_18975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LCG53_18980	COG1444	tRNA N-acetyltransferase activity
LCG53_19000	COG1803	Methylglyoxal synthase
LCG53_19015	COG0252	asparaginase activity
LCG53_19035	COG1263	PTS System
LCG53_19035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCG53_19040	COG0366	Alpha amylase catalytic
LCG53_19045	COG0110	maltose O-acetyltransferase activity
LCG53_19050	COG1522	sequence-specific DNA binding
LCG53_19055	COG5006	permease, DMT superfamily
LCG53_19080	COG3068	Protein conserved in bacteria
LCG53_19090	COG0739	heme binding
LCG53_19110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LCG53_19115	COG1121	(ABC) transporter
LCG53_19120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LCG53_19125	COG0583	DNA-binding transcription factor activity
LCG53_19135	COG1573	uracil-dna glycosylase
LCG53_19140	COG2962	Rard protein
LCG53_19145	COG2827	Endonuclease containing a URI domain
LCG53_19160	COG1842	Phage shock protein A
LCG53_19165	COG0204	Acyl-transferase
LCG53_19185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCG53_19195	COG0484	heat shock protein binding
LCG53_19230	COG2801	Transposase and inactivated derivatives
LCG53_19245	COG1289	transmembrane transporter activity
LCG53_19250	COG1566	PFAM secretion protein HlyD family protein
LCG53_19265	COG1051	belongs to the nudix hydrolase family
LCG53_19270	COG3150	esterase
LCG53_19280	COG3151	Protein conserved in bacteria
LCG53_19285	COG0494	nUDIX hydrolase
LCG53_19290	COG1538	Outer membrane efflux protein
LCG53_19295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LCG53_19295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LCG53_19300	COG1560	Kdo2-lipid A biosynthetic process
LCG53_19315	COG2771	luxR family
LCG53_19320	COG3916	Acyl-homoserine-lactone synthase
LCG53_19330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LCG53_19335	COG2213	PTS system mannitol-specific
LCG53_19335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCG53_19340	COG0246	Mannitol dehydrogenase
LCG53_19345	COG3722	fumarate hydratase activity
LCG53_19350	COG3263	regulation of cellular component size
LCG53_19370	COG1671	Belongs to the UPF0178 family
LCG53_19385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCG53_19390	COG0513	Belongs to the DEAD box helicase family
LCG53_19410	COG1575	Belongs to the MenA family. Type 1 subfamily
LCG53_19415	COG1169	isochorismate synthase
LCG53_19420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LCG53_19425	COG0596	Alpha beta hydrolase
LCG53_19430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LCG53_19440	COG0318	PFAM AMP-dependent synthetase and ligase
LCG53_19445	COG3291	Pkd domain containing protein
LCG53_19450	COG2949	membrane
LCG53_19455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCG53_19465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LCG53_19495	COG2873	o-acetylhomoserine
LCG53_19505	COG1979	alcohol dehydrogenase
LCG53_19520	COG4221	oxidoreductase activity
LCG53_19540	COG1285	pathogenesis
LCG53_19555	COG1368	sulfuric ester hydrolase activity
LCG53_19560	COG1522	sequence-specific DNA binding
LCG53_19570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LCG53_19580	COG1058	Belongs to the CinA family
LCG53_19580	COG1546	Belongs to the CinA family
LCG53_19585	COG1988	membrane-bound metal-dependent
LCG53_19600	COG0561	phosphatase activity
LCG53_19605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LCG53_19615	COG1011	Hydrolase
LCG53_19630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LCG53_19635	COG0019	diaminopimelate decarboxylase activity
LCG53_19645	COG1965	Belongs to the frataxin family
LCG53_19650	COG0400	carboxylic ester hydrolase activity
LCG53_19655	COG3072	Adenylate cyclase
LCG53_19660	COG0181	hydroxymethylbilane synthase activity
LCG53_19665	COG1587	Uroporphyrinogen-III synthase
LCG53_19670	COG2959	enzyme of heme biosynthesis
LCG53_19675	COG3071	HemY protein
LCG53_19685	COG0312	modulator of DNA gyrase
LCG53_19690	COG3028	Belongs to the UPF0307 family
LCG53_19700	COG2926	Belongs to the UPF0265 family
LCG53_19730	COG1396	sequence-specific DNA binding
LCG53_19735	COG3135	benzoate transporter
LCG53_19760	COG0840	transmembrane signaling receptor activity
LCG53_19765	COG3047	cAMP biosynthetic process
LCG53_19770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LCG53_19775	COG2197	response regulator
LCG53_19815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCG53_19850	COG1396	sequence-specific DNA binding
LCG53_19870	COG1278	Cold shock
LCG53_19900	COG3706	GGDEF domain
LCG53_19905	COG0347	Belongs to the P(II) protein family
LCG53_19910	COG0004	ammonium transporteR
LCG53_19920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCG53_19925	COG1074	ATP-dependent DNA helicase activity
LCG53_19930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LCG53_19935	COG2259	Doxx family
LCG53_19940	COG1741	Belongs to the pirin family
LCG53_19950	COG0583	DNA-binding transcription factor activity
LCG53_19975	COG1175	transmembrane transport
LCG53_19985	COG3842	ATPase activity
LCG53_20015	COG0456	acetyltransferase
LCG53_20020	COG0753	catalase activity
LCG53_20040	COG0494	nUDIX hydrolase
LCG53_20045	COG0628	permease
LCG53_20055	COG2957	Belongs to the agmatine deiminase family
LCG53_20070	COG2957	Belongs to the agmatine deiminase family
LCG53_20075	COG0583	DNA-binding transcription factor activity
LCG53_20090	COG1461	Dihydroxyacetone kinase
LCG53_20095	COG2376	Dihydroxyacetone kinase
LCG53_20100	COG2252	PERMEase
LCG53_20105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LCG53_20135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LCG53_20140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LCG53_20145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LCG53_20150	COG0049	tRNA binding
LCG53_20155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LCG53_20160	COG2168	tRNA wobble position uridine thiolation
LCG53_20170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LCG53_20175	COG0251	oxidation-reduction process
LCG53_20180	COG2964	Protein conserved in bacteria
LCG53_20185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LCG53_20190	COG0085	RNA polymerase activity
LCG53_20195	COG0222	ribosome binding
LCG53_20200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LCG53_20205	COG0081	regulation of translation
LCG53_20210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LCG53_20215	COG0250	Participates in transcription elongation, termination and antitermination
LCG53_20230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LCG53_20255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LCG53_20260	COG0569	domain protein
LCG53_20265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCG53_20270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LCG53_20275	COG3005	denitrification pathway
LCG53_20280	COG0243	molybdopterin cofactor binding
LCG53_20315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LCG53_20325	COG2204	response regulator
LCG53_20335	COG2205	protein histidine kinase activity
LCG53_20355	COG0516	GMP reductase activity
LCG53_20355	COG0517	IMP dehydrogenase activity
LCG53_20365	COG1522	sequence-specific DNA binding
LCG53_20370	COG2502	aspartate--ammonia ligase
LCG53_20385	COG0583	DNA-binding transcription factor activity
LCG53_20395	COG0542	response to heat
LCG53_20405	COG0564	pseudouridine synthase activity
LCG53_20410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCG53_20415	COG3681	Belongs to the UPF0597 family
LCG53_20420	COG2964	Protein conserved in bacteria
LCG53_20425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LCG53_20430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LCG53_20435	COG1979	alcohol dehydrogenase
LCG53_20440	COG2207	Transcriptional regulator
LCG53_20445	COG3040	lipid binding
LCG53_20465	COG0583	DNA-binding transcription factor activity
LCG53_20485	COG0540	Belongs to the ATCase OTCase family
LCG53_20490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LCG53_20495	COG1438	arginine binding
LCG53_20500	COG1288	antiporter activity
LCG53_20505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LCG53_20545	COG3250	beta-galactosidase activity
LCG53_20550	COG1609	Transcriptional regulator
LCG53_20555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCG53_20565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LCG53_20570	COG2017	converts alpha-aldose to the beta-anomer
LCG53_20575	COG0667	Aldo Keto reductase
LCG53_20580	COG1968	undecaprenyl-diphosphatase activity
LCG53_20585	COG3806	Anti-sigma factor
LCG53_20590	COG1595	DNA-templated transcription, initiation
LCG53_20610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LCG53_20615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LCG53_20620	COG0477	Major facilitator Superfamily
LCG53_20635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCG53_20640	COG1131	(ABC) transporter
LCG53_20645	COG0842	Transport permease protein
LCG53_20650	COG0842	Transport permease protein
LCG53_20655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCG53_20670	COG2116	formate transmembrane transporter activity
LCG53_20675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCG53_20675	COG1648	precorrin-2 dehydrogenase activity
LCG53_20680	COG2239	Acts as a magnesium transporter
LCG53_20685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LCG53_20690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LCG53_20700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LCG53_20710	COG0514	ATP-dependent DNA helicase (RecQ)
LCG53_20715	COG0514	ATP-dependent DNA helicase (RecQ)
LCG53_20720	COG2050	protein possibly involved in aromatic compounds catabolism
LCG53_20735	COG2258	MOSC domain
LCG53_20740	COG1177	transmembrane transport
LCG53_20745	COG1176	ABC-type spermidine putrescine transport system, permease component I
LCG53_20750	COG3842	ATPase activity
LCG53_20770	COG0174	glutamine synthetase
LCG53_20790	COG3045	CreA protein
LCG53_20795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCG53_20800	COG0443	Heat shock 70 kDa protein
LCG53_20815	COG0366	Alpha amylase catalytic
LCG53_20825	COG4310	Domain of unknown function (DUF2172)
LCG53_20860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCG53_20865	COG0745	RESPONSE REGULATOR receiver
LCG53_20870	COG2205	protein histidine kinase activity
LCG53_20880	COG0281	malic enzyme
LCG53_20885	COG0702	epimerase
LCG53_20890	COG0254	rRNA binding
LCG53_20895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LCG53_20900	COG1309	transcriptional regulator
LCG53_20920	COG0129	dihydroxy-acid dehydratase activity
LCG53_20930	COG3978	acetolactate synthase activity
LCG53_20940	COG0606	chelatase, subunit chli
LCG53_20945	COG0204	Acyl-transferase
LCG53_20950	COG0204	Acyl-transferase
LCG53_20955	COG1683	Conserved Protein
LCG53_20965	COG1335	isochorismatase
LCG53_20975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LCG53_20980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LCG53_20990	COG3084	Protein conserved in bacteria
LCG53_20995	COG2203	Gaf domain
LCG53_20995	COG3706	GGDEF domain
LCG53_20995	COG4251	negative regulation of phosphorylation
LCG53_20995	COG5001	Diguanylate cyclase
LCG53_21010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LCG53_21015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LCG53_21020	COG1561	YicC-like family, N-terminal region
LCG53_21030	COG1519	Transferase
LCG53_21035	COG0859	PFAM glycosyl transferase family 9
LCG53_21040	COG0463	Glycosyl transferase, family 2
LCG53_21045	COG0859	PFAM glycosyl transferase family 9
LCG53_21050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LCG53_21055	COG2990	Protein conserved in bacteria
LCG53_21060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LCG53_21070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LCG53_21075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LCG53_21080	COG2003	Belongs to the UPF0758 family
LCG53_21085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LCG53_21090	COG0756	dUTP diphosphatase activity
LCG53_21095	COG1309	transcriptional regulator
LCG53_21110	COG0668	transmembrane transport
LCG53_21120	COG0166	Belongs to the GPI family
LCG53_21125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LCG53_21130	COG0583	DNA-binding transcription factor activity
LCG53_21140	COG0045	succinate-CoA ligase (ADP-forming) activity
LCG53_21140	COG1042	CoA-binding domain protein
LCG53_21140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCG53_21175	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LCG53_21180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCG53_21185	COG1739	Uncharacterized protein family UPF0029
LCG53_21190	COG0006	proline dipeptidase activity
LCG53_21195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCG53_21200	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCG53_21200	COG1024	Enoyl-CoA hydratase
LCG53_21205	COG0183	Belongs to the thiolase family
LCG53_21240	COG0425	Belongs to the sulfur carrier protein TusA family
LCG53_21245	COG0251	oxidation-reduction process
LCG53_21250	COG2885	chlorophyll binding
LCG53_21260	COG1335	isochorismatase
LCG53_21265	COG2818	Glycosylase
LCG53_21270	COG0752	glycyl-tRNA synthetase alpha subunit
LCG53_21275	COG0751	glycine-tRNA ligase activity
LCG53_21290	COG3604	Transcriptional regulator
LCG53_21295	COG1773	rubredoxin
LCG53_21295	COG0426	domain, Protein
LCG53_21300	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCG53_21310	COG0348	domain, Protein
LCG53_21320	COG3033	Beta-eliminating lyase
LCG53_21325	COG0814	amino acid
LCG53_21330	COG0814	amino acid
LCG53_21350	COG5001	Diguanylate cyclase
LCG53_21350	COG4251	negative regulation of phosphorylation
LCG53_21350	COG3706	GGDEF domain
LCG53_21350	COG2203	Gaf domain
LCG53_21360	COG1609	Transcriptional regulator
LCG53_21400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCG53_21415	COG2960	long-chain fatty acid transporting porin activity
LCG53_21425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LCG53_21440	COG3118	belongs to the thioredoxin family
LCG53_21445	COG0513	Belongs to the DEAD box helicase family
LCG53_21450	COG0248	Ppx GppA phosphatase
LCG53_21460	COG0742	ribosomal rna small subunit methyltransferase
LCG53_21480	COG0084	hydrolase, TatD family'
LCG53_21485	COG0805	protein transport
LCG53_21490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCG53_21495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCG53_21500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LCG53_21505	COG3165	ubiquinone biosynthetic process from chorismate
LCG53_21515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LCG53_21520	COG0402	S-adenosylhomocysteine deaminase activity
LCG53_21555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LCG53_21560	COG0848	biopolymer transport protein
LCG53_21565	COG0811	peptide transport
LCG53_21570	COG0811	peptide transport
LCG53_21580	COG2771	luxR family
LCG53_21585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LCG53_21590	COG1349	DNA-binding transcription factor activity
LCG53_21595	COG0745	RESPONSE REGULATOR receiver
LCG53_21600	COG2205	protein histidine kinase activity
LCG53_21610	COG4452	Inner membrane protein CreD
LCG53_21615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LCG53_21620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LCG53_21625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LCG53_21630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LCG53_21635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LCG53_21640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LCG53_21645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LCG53_21655	COG0356	it plays a direct role in the translocation of protons across the membrane
LCG53_21665	COG1475	DNA binding
LCG53_21670	COG1192	Involved in chromosome partitioning
LCG53_21675	COG0357	Ribosomal RNA small subunit methyltransferase G
LCG53_21680	COG0445	tRNA wobble uridine modification
LCG53_21685	COG0716	FMN binding
LCG53_21695	COG4615	Cyclic peptide transporter
LCG53_21700	COG1120	ATPase activity
LCG53_21705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCG53_21715	COG3550	peptidyl-serine autophosphorylation
LCG53_21770	COG1695	Transcriptional regulator
LCG53_21795	COG3173	Aminoglycoside phosphotransferase
LCG53_21895	COG4974	Belongs to the 'phage' integrase family
LCG53_21900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LCG53_21905	COG0706	membrane insertase activity
LCG53_21910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LCG53_21915	COG0594	ribonuclease P activity
LCG53_21920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LCG53_21925	COG1126	abc transporter atp-binding protein