locus-tag	class	description
KAM376_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KAM376_00020	COG0592	DNA-directed DNA polymerase activity
KAM376_00040	COG0187	DNA topoisomerase II activity
KAM376_00050	COG2207	Transcriptional regulator
KAM376_00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KAM376_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
KAM376_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
KAM376_00090	COG3977	Valine--pyruvate aminotransferase
KAM376_00130	COG2814	Major facilitator Superfamily
KAM376_00140	COG0745	RESPONSE REGULATOR receiver
KAM376_00150	COG2205	protein histidine kinase activity
KAM376_00190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM376_00200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_00200	COG4191	Histidine kinase
KAM376_00210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_00230	COG1309	transcriptional regulator
KAM376_00250	COG0561	phosphatase activity
KAM376_00260	COG2267	carboxylic ester hydrolase activity
KAM376_00270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAM376_00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAM376_00300	COG1758	RNA polymerase activity
KAM376_00320	COG0859	PFAM glycosyl transferase family 9
KAM376_00330	COG3642	lipopolysaccharide core region biosynthetic process
KAM376_00410	COG0589	response to stress
KAM376_00420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAM376_00430	COG3706	GGDEF domain
KAM376_00440	COG1528	Iron-storage protein
KAM376_00450	COG2081	HI0933 family
KAM376_00460	COG2223	nitrite transmembrane transporter activity
KAM376_00470	COG1280	lysine exporter protein (LysE YggA)
KAM376_00500	COG3039	Transposase
KAM376_00510	COG0840	transmembrane signaling receptor activity
KAM376_00520	COG3039	Transposase
KAM376_00540	COG2205	protein histidine kinase activity
KAM376_00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_00560	COG3275	phosphorelay sensor kinase activity
KAM376_00570	COG3279	Response regulator of the LytR AlgR family
KAM376_00580	COG2223	nitrite transmembrane transporter activity
KAM376_00590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KAM376_00600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KAM376_00610	COG4206	TonB-dependent receptor
KAM376_00630	COG4206	TonB-dependent receptor
KAM376_00670	COG1609	Transcriptional regulator
KAM376_00680	COG3250	beta-galactosidase activity
KAM376_00690	COG2731	YhcH YjgK YiaL family protein
KAM376_00700	COG0531	amino acid
KAM376_00710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM376_00720	COG0531	amino acid
KAM376_00730	COG0385	Bile acid
KAM376_00740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KAM376_00790	COG0583	DNA-binding transcription factor activity
KAM376_00810	COG1079	Belongs to the binding-protein-dependent transport system permease family
KAM376_00820	COG4603	Belongs to the binding-protein-dependent transport system permease family
KAM376_00830	COG3845	ABC transporter
KAM376_00840	COG1744	ABC transporter substrate-binding protein PnrA-like
KAM376_00850	COG0210	DNA helicase
KAM376_00870	COG2856	Zn peptidase
KAM376_00910	COG0583	DNA-binding transcription factor activity
KAM376_01000	COG1280	lysine exporter protein (LysE YggA)
KAM376_01020	COG2962	Rard protein
KAM376_01040	COG1012	belongs to the aldehyde dehydrogenase family
KAM376_01050	COG1396	sequence-specific DNA binding
KAM376_01060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KAM376_01080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAM376_01080	COG0519	Catalyzes the synthesis of GMP from XMP
KAM376_01100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM376_01140	COG1322	Protein conserved in bacteria
KAM376_01150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM376_01160	COG0569	domain protein
KAM376_01170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM376_01170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM376_01180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KAM376_01190	COG0242	peptide deformylase activity
KAM376_01210	COG0758	DNA mediated transformation
KAM376_01220	COG2922	Belongs to the Smg family
KAM376_01230	COG0551	DNA topoisomerase type I activity
KAM376_01240	COG0009	L-threonylcarbamoyladenylate synthase
KAM376_01250	COG0408	coproporphyrinogen oxidase activity
KAM376_01260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KAM376_01280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KAM376_01300	COG3078	GTPase activator activity
KAM376_01320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAM376_01330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KAM376_01340	COG2204	response regulator
KAM376_01350	COG3852	Histidine kinase
KAM376_01370	COG0174	glutamine synthetase
KAM376_01380	COG1217	gtp-binding protein TYPA
KAM376_01390	COG1295	ribonuclease BN
KAM376_01400	COG1490	D-aminoacyl-tRNA deacylase activity
KAM376_01420	COG0456	acetyltransferase
KAM376_01440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAM376_01450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAM376_01460	COG2610	gluconate transmembrane transporter activity
KAM376_01470	COG3265	gluconokinase activity
KAM376_01480	COG0129	dihydroxy-acid dehydratase activity
KAM376_01490	COG0800	Aldolase
KAM376_01520	COG1609	Transcriptional regulator
KAM376_01540	COG4942	peptidase
KAM376_01550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KAM376_01560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM376_01570	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KAM376_01580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KAM376_01590	COG0316	Belongs to the HesB IscA family
KAM376_01590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KAM376_01600	COG1040	competence protein
KAM376_01610	COG0596	Alpha beta hydrolase
KAM376_01640	COG2183	response to ionizing radiation
KAM376_01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAM376_01670	COG2205	protein histidine kinase activity
KAM376_01690	COG0051	transcription antitermination factor activity, RNA binding
KAM376_01700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KAM376_01710	COG0088	Forms part of the polypeptide exit tunnel
KAM376_01720	COG0089	rRNA binding
KAM376_01730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KAM376_01740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KAM376_01750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KAM376_01760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KAM376_01770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KAM376_01780	COG0255	Belongs to the universal ribosomal protein uL29 family
KAM376_01790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KAM376_01800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KAM376_01810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KAM376_01820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KAM376_01830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KAM376_01840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KAM376_01850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KAM376_01860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KAM376_01870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KAM376_01880	COG1841	ribosomal large subunit assembly
KAM376_01890	COG0200	Binds to the 23S rRNA
KAM376_01900	COG0201	protein transport
KAM376_01910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KAM376_01920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KAM376_01930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KAM376_01940	COG0202	RNA polymerase activity
KAM376_01950	COG0203	ribosomal protein L17
KAM376_02020	COG2249	NAD(P)H dehydrogenase (quinone) activity
KAM376_02040	COG0583	DNA-binding transcription factor activity
KAM376_02050	COG4221	oxidoreductase activity
KAM376_02080	COG1770	oligopeptidase
KAM376_02090	COG2358	TRAP transporter, solute receptor (TAXI family
KAM376_02120	COG3714	YhhN family
KAM376_02150	COG0583	DNA-binding transcription factor activity
KAM376_02180	COG1301	dicarboxylic acid transport
KAM376_02200	COG2095	MarC family integral membrane protein
KAM376_02220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM376_02240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KAM376_02260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAM376_02310	COG0742	ribosomal rna small subunit methyltransferase
KAM376_02320	COG0552	protein localization to endoplasmic reticulum
KAM376_02330	COG2884	Cell division ATP-binding protein ftsE
KAM376_02340	COG2177	Part of the ABC transporter FtsEX involved in
KAM376_02360	COG0288	reversible hydration of carbon dioxide
KAM376_02370	COG2188	Transcriptional regulator
KAM376_02380	COG1228	amidohydrolase
KAM376_02390	COG0010	Belongs to the arginase family
KAM376_02400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KAM376_02410	COG2986	histidine ammonia-lyase
KAM376_02420	COG0387	Pfam Sodium calcium exchanger
KAM376_02430	COG2200	EAL domain
KAM376_02530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM376_02540	COG1459	type II secretion system
KAM376_02560	COG2165	general secretion pathway protein
KAM376_02630	COG1077	Cell shape determining protein MreB Mrl
KAM376_02640	COG1792	Involved in formation and maintenance of cell shape
KAM376_02650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KAM376_02660	COG0424	maF-like protein
KAM376_02670	COG1530	ribonuclease E activity
KAM376_02680	COG3164	Protein of unknown function
KAM376_02700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM376_02710	COG0312	modulator of DNA gyrase
KAM376_02760	COG1263	PTS System
KAM376_02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_02770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_02770	COG1263	PTS System
KAM376_02780	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KAM376_02810	COG0477	Major facilitator Superfamily
KAM376_02830	COG2321	neutral zinc metallopeptidase
KAM376_02900	COG0189	ligase activity
KAM376_02910	COG0642	Histidine kinase
KAM376_02920	COG0745	RESPONSE REGULATOR receiver
KAM376_02950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KAM376_02960	COG0352	thiamine-phosphate diphosphorylase activity
KAM376_02970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAM376_02990	COG2022	thiamine diphosphate biosynthetic process
KAM376_03000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAM376_03010	COG3039	Transposase
KAM376_03110	COG3932	Exopolysaccharide synthesis, ExoD
KAM376_03150	COG1733	regulation of RNA biosynthetic process
KAM376_03190	COG1214	PFAM Peptidase M22, glycoprotease
KAM376_03190	COG0456	acetyltransferase
KAM376_03200	COG2226	methyltransferase
KAM376_03220	COG1494	fructose-1,6-bisphosphatase
KAM376_03240	COG3071	HemY protein
KAM376_03250	COG2959	enzyme of heme biosynthesis
KAM376_03270	COG0181	hydroxymethylbilane synthase activity
KAM376_03280	COG3072	Adenylate cyclase
KAM376_03290	COG0400	carboxylic ester hydrolase activity
KAM376_03300	COG1965	Belongs to the frataxin family
KAM376_03320	COG0019	diaminopimelate decarboxylase activity
KAM376_03330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KAM376_03360	COG1011	Hydrolase
KAM376_03380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KAM376_03390	COG0561	phosphatase activity
KAM376_03420	COG1988	membrane-bound metal-dependent
KAM376_03430	COG1546	Belongs to the CinA family
KAM376_03430	COG1058	Belongs to the CinA family
KAM376_03450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KAM376_03470	COG1522	sequence-specific DNA binding
KAM376_03480	COG1368	sulfuric ester hydrolase activity
KAM376_03510	COG1285	pathogenesis
KAM376_03550	COG4221	oxidoreductase activity
KAM376_03580	COG1979	alcohol dehydrogenase
KAM376_03600	COG2873	o-acetylhomoserine
KAM376_03660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KAM376_03680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KAM376_03690	COG2949	membrane
KAM376_03700	COG3291	Pkd domain containing protein
KAM376_03710	COG0318	PFAM AMP-dependent synthetase and ligase
KAM376_03730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KAM376_03740	COG0596	Alpha beta hydrolase
KAM376_03750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KAM376_03760	COG1169	isochorismate synthase
KAM376_03770	COG1575	Belongs to the MenA family. Type 1 subfamily
KAM376_03810	COG0513	Belongs to the DEAD box helicase family
KAM376_03820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM376_03860	COG1671	Belongs to the UPF0178 family
KAM376_03900	COG3263	regulation of cellular component size
KAM376_03910	COG3722	fumarate hydratase activity
KAM376_03920	COG0246	Mannitol dehydrogenase
KAM376_03930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_03930	COG2213	PTS system mannitol-specific
KAM376_03940	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KAM376_03960	COG3916	Acyl-homoserine-lactone synthase
KAM376_03970	COG2771	luxR family
KAM376_04000	COG1560	Kdo2-lipid A biosynthetic process
KAM376_04010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KAM376_04010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KAM376_04020	COG1538	Outer membrane efflux protein
KAM376_04030	COG0494	nUDIX hydrolase
KAM376_04040	COG3151	Protein conserved in bacteria
KAM376_04060	COG3150	esterase
KAM376_04070	COG1051	belongs to the nudix hydrolase family
KAM376_04100	COG1566	PFAM secretion protein HlyD family protein
KAM376_04110	COG1289	transmembrane transporter activity
KAM376_04210	COG0484	heat shock protein binding
KAM376_04230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM376_04270	COG0204	Acyl-transferase
KAM376_04280	COG1842	Phage shock protein A
KAM376_04310	COG2827	Endonuclease containing a URI domain
KAM376_04320	COG2962	Rard protein
KAM376_04330	COG1573	uracil-dna glycosylase
KAM376_04350	COG0583	DNA-binding transcription factor activity
KAM376_04360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAM376_04370	COG1121	(ABC) transporter
KAM376_04380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KAM376_04420	COG0739	heme binding
KAM376_04440	COG3068	Protein conserved in bacteria
KAM376_04480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KAM376_04500	COG1546	Belongs to the CinA family
KAM376_04510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAM376_04520	COG2137	regulation of response to DNA damage stimulus
KAM376_04530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KAM376_04540	COG0527	aspartate kinase activity
KAM376_04550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KAM376_04560	COG1686	Belongs to the peptidase S11 family
KAM376_04570	COG0586	Pfam SNARE associated Golgi protein
KAM376_04580	COG1253	flavin adenine dinucleotide binding
KAM376_04590	COG0525	valine-tRNA ligase activity
KAM376_04600	COG2927	DNA polymerase III (CHI subunit)
KAM376_04610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAM376_04620	COG0795	lipopolysaccharide-transporting ATPase activity
KAM376_04630	COG0795	lipopolysaccharide-transporting ATPase activity
KAM376_04930	COG4695	Portal protein
KAM376_05110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAM376_05140	COG4974	Belongs to the 'phage' integrase family
KAM376_05170	COG0004	ammonium transporteR
KAM376_05180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM376_05220	COG2165	general secretion pathway protein
KAM376_05230	COG0084	hydrolase, TatD family'
KAM376_05240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM376_05260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KAM376_05270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KAM376_05280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KAM376_05290	COG0813	purine-nucleoside phosphorylase activity
KAM376_05300	COG5001	Diguanylate cyclase
KAM376_05300	COG3447	MASE1 domain protein
KAM376_05300	COG5002	protein histidine kinase activity
KAM376_05320	COG0560	Phosphoserine phosphatase
KAM376_05350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KAM376_05370	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KAM376_05380	COG0776	regulation of translation
KAM376_05410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM376_05420	COG0735	belongs to the Fur family
KAM376_05460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KAM376_05470	COG0513	Belongs to the DEAD box helicase family
KAM376_05480	COG3022	response to hydroperoxide
KAM376_05510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KAM376_05520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KAM376_05530	COG0762	integral membrane protein
KAM376_05540	COG1872	DUF167
KAM376_05580	COG3112	Uncharacterised protein family (UPF0231)
KAM376_05590	COG3835	regulator
KAM376_05600	COG2610	gluconate transmembrane transporter activity
KAM376_05610	COG1929	Belongs to the glycerate kinase type-1 family
KAM376_05640	COG0583	DNA-binding transcription factor activity
KAM376_05650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM376_05680	COG0347	Belongs to the P(II) protein family
KAM376_05710	COG3842	ATPase activity
KAM376_05720	COG2837	iron assimilation
KAM376_05730	COG1438	arginine binding
KAM376_05740	COG1126	abc transporter atp-binding protein
KAM376_05750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_05760	COG4215	(ABC) transporter
KAM376_05770	COG4160	amino acid transport
KAM376_05780	COG0039	L-malate dehydrogenase activity
KAM376_05800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KAM376_05810	COG1017	nitric oxide dioxygenase activity
KAM376_05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KAM376_05830	COG4536	flavin adenine dinucleotide binding
KAM376_05840	COG4137	Cytochrome C assembly protein
KAM376_05850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KAM376_05860	COG0228	four-way junction DNA binding
KAM376_05870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KAM376_05880	COG0336	Belongs to the RNA methyltransferase TrmD family
KAM376_05890	COG0335	large ribosomal subunit rRNA binding
KAM376_05910	COG3066	DNA modification
KAM376_05920	COG1051	belongs to the nudix hydrolase family
KAM376_05940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KAM376_05950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KAM376_05960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAM376_05980	COG0583	DNA-binding transcription factor activity
KAM376_05990	COG0640	Transcriptional regulator
KAM376_06000	COG0268	Binds directly to 16S ribosomal RNA
KAM376_06010	COG0728	peptidoglycan biosynthetic process
KAM376_06020	COG0196	riboflavin kinase activity
KAM376_06030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KAM376_06040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KAM376_06050	COG1047	Peptidyl-prolyl cis-trans
KAM376_06060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KAM376_06140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KAM376_06140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM376_06170	COG1854	S-ribosylhomocysteine lyase activity
KAM376_06180	COG3706	GGDEF domain
KAM376_06190	COG0557	exoribonuclease II activity
KAM376_06200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAM376_06220	COG2153	protein acetylation
KAM376_06240	COG1914	H( )-stimulated, divalent metal cation uptake system
KAM376_06250	COG0360	Binds together with S18 to 16S ribosomal RNA
KAM376_06260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KAM376_06270	COG0359	binds to the 23S rRNA
KAM376_06350	COG1238	metal cluster binding
KAM376_06360	COG0612	Peptidase, M16
KAM376_06370	COG2918	glutathione biosynthetic process
KAM376_06380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAM376_06390	COG1027	Aspartate ammonia-lyase
KAM376_06400	COG3030	protein affecting phage T7 exclusion by the F plasmid
KAM376_06410	COG0534	Mate efflux family protein
KAM376_06420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAM376_06430	COG0459	protein refolding
KAM376_06470	COG0564	pseudouridine synthase activity
KAM376_06480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KAM376_06490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KAM376_06510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KAM376_06520	COG4208	sulfate ABC transporter
KAM376_06530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KAM376_06540	COG0583	DNA-binding transcription factor activity
KAM376_06550	COG3397	chitin binding
KAM376_06610	COG1328	CTP reductase activity
KAM376_06620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KAM376_06650	COG1448	Aminotransferase
KAM376_06660	COG2194	sulfuric ester hydrolase activity
KAM376_06700	COG1215	transferase activity, transferring glycosyl groups
KAM376_06720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KAM376_06730	COG0457	Tetratricopeptide repeat
KAM376_06730	COG3118	belongs to the thioredoxin family
KAM376_06800	COG0513	Belongs to the DEAD box helicase family
KAM376_06830	COG4166	transmembrane transport
KAM376_06860	COG1024	Enoyl-CoA hydratase
KAM376_06890	COG4221	oxidoreductase activity
KAM376_06900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM376_06910	COG0442	prolyl-tRNA aminoacylation
KAM376_06920	COG0840	transmembrane signaling receptor activity
KAM376_06940	COG0632	four-way junction helicase activity
KAM376_06950	COG2255	four-way junction helicase activity
KAM376_06960	COG1271	oxidase subunit
KAM376_06970	COG1294	oxidase, subunit
KAM376_06980	COG3790	cyd operon protein YbgE
KAM376_06990	COG0824	Thioesterase
KAM376_07000	COG0811	peptide transport
KAM376_07030	COG0823	Involved in the tonB-independent uptake of proteins
KAM376_07040	COG2885	chlorophyll binding
KAM376_07050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KAM376_07060	COG0840	transmembrane signaling receptor activity
KAM376_07070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KAM376_07090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAM376_07100	COG1640	4-alpha-glucanotransferase
KAM376_07110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KAM376_07170	COG2130	NADP-dependent
KAM376_07180	COG1846	Transcriptional regulator
KAM376_07240	COG0561	phosphatase activity
KAM376_07270	COG0733	neurotransmitter:sodium symporter activity
KAM376_07280	COG0733	neurotransmitter:sodium symporter activity
KAM376_07310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM376_07340	COG1794	racemase activity, acting on amino acids and derivatives
KAM376_07360	COG1022	Amp-dependent synthetase and ligase
KAM376_07380	COG0456	acetyltransferase
KAM376_07410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KAM376_07420	COG5002	protein histidine kinase activity
KAM376_07420	COG5001	Diguanylate cyclase
KAM376_07470	COG0456	acetyltransferase
KAM376_07490	COG0456	acetyltransferase
KAM376_07500	COG1902	pentaerythritol trinitrate reductase activity
KAM376_07520	COG2852	Protein conserved in bacteria
KAM376_07540	COG2957	Belongs to the agmatine deiminase family
KAM376_07550	COG0154	amidase activity
KAM376_07560	COG2801	Transposase and inactivated derivatives
KAM376_07610	COG1917	Cupin 2, conserved barrel domain protein
KAM376_07610	COG2207	Transcriptional regulator
KAM376_07630	COG0513	Belongs to the DEAD box helicase family
KAM376_07640	COG2203	Gaf domain
KAM376_07640	COG2199	diguanylate cyclase activity
KAM376_07710	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
KAM376_07730	COG0577	efflux transmembrane transporter activity
KAM376_07730	COG1136	(ABC) transporter
KAM376_07740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_07750	COG0745	RESPONSE REGULATOR receiver
KAM376_07760	COG2205	protein histidine kinase activity
KAM376_07830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM376_07850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KAM376_07870	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KAM376_07880	COG1178	ABC-type Fe3 transport system permease component
KAM376_07890	COG4143	(ABC) transporter
KAM376_07920	COG0066	3-isopropylmalate dehydratase activity
KAM376_07930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KAM376_07940	COG0473	3-isopropylmalate dehydrogenase activity
KAM376_07950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KAM376_07970	COG0671	phosphoesterase, PA-phosphatase related
KAM376_08000	COG0028	Belongs to the TPP enzyme family
KAM376_08010	COG0440	acetolactate synthase activity
KAM376_08020	COG0280	phosphate acetyltransferase
KAM376_08020	COG0857	belongs to the CobB CobQ family
KAM376_08030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KAM376_08050	COG3013	Belongs to the UPF0304 family
KAM376_08060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KAM376_08070	COG2716	regulation of RNA biosynthetic process
KAM376_08080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAM376_08090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KAM376_08100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KAM376_08130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KAM376_08170	COG2198	Histidine kinase
KAM376_08170	COG0784	Response regulator, receiver
KAM376_08170	COG5002	protein histidine kinase activity
KAM376_08200	COG2205	protein histidine kinase activity
KAM376_08200	COG0784	Response regulator, receiver
KAM376_08240	COG1464	Belongs to the NlpA lipoprotein family
KAM376_08250	COG2011	ABC-type metal ion transport system permease component
KAM376_08260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAM376_08300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KAM376_08300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KAM376_08310	COG0802	atpase or kinase
KAM376_08330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KAM376_08340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KAM376_08350	COG1923	regulation of RNA biosynthetic process
KAM376_08360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KAM376_08370	COG0330	HflC and HflK could
KAM376_08380	COG0330	HflC and HflK could
KAM376_08390	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KAM376_08400	COG0142	geranyltranstransferase activity
KAM376_08410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KAM376_08420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KAM376_08430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KAM376_08440	COG3314	Sporulation integral membrane protein YlbJ
KAM376_08450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM376_08460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KAM376_08480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KAM376_08490	COG2967	ApaG domain
KAM376_08500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KAM376_08510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KAM376_08530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KAM376_08540	COG3178	'Phosphotransferase
KAM376_08550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KAM376_08560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAM376_08570	COG2252	PERMEase
KAM376_08590	COG0488	(ABC) transporter
KAM376_08600	COG0741	lytic transglycosylase activity
KAM376_08610	COG0463	Glycosyl transferase, family 2
KAM376_08630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KAM376_08690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM376_08710	COG3721	Heme iron utilization protein
KAM376_08720	COG0748	coenzyme F420 binding
KAM376_08770	COG2814	Major facilitator Superfamily
KAM376_08780	COG2202	Pas domain
KAM376_08780	COG2205	protein histidine kinase activity
KAM376_08800	COG2226	methyltransferase
KAM376_08820	COG1765	OsmC-like protein
KAM376_08850	COG3954	Phosphoribulokinase
KAM376_08860	COG3089	Belongs to the UPF0270 family
KAM376_08870	COG2203	Gaf domain
KAM376_08870	COG4251	negative regulation of phosphorylation
KAM376_08870	COG3706	GGDEF domain
KAM376_08870	COG5001	Diguanylate cyclase
KAM376_08880	COG0429	hydrolase of the alpha beta-hydrolase fold
KAM376_08890	COG0784	Response regulator, receiver
KAM376_08890	COG0835	chemotaxis
KAM376_08910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KAM376_08920	COG1047	Peptidyl-prolyl cis-trans
KAM376_08930	COG2900	Belongs to the SlyX family
KAM376_08950	COG0545	Peptidyl-prolyl cis-trans isomerase
KAM376_08960	COG2204	response regulator
KAM376_09000	COG0737	Belongs to the 5'-nucleotidase family
KAM376_09030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAM376_09040	COG0506	proline dehydrogenase activity
KAM376_09040	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KAM376_09040	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KAM376_09060	COG0114	fumarate hydratase activity
KAM376_09080	COG1566	PFAM secretion protein HlyD family protein
KAM376_09190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAM376_09210	COG1280	lysine exporter protein (LysE YggA)
KAM376_09220	COG0826	peptidase U32
KAM376_09240	COG3813	Protein conserved in bacteria
KAM376_09280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KAM376_09330	COG0300	oxidoreductase activity
KAM376_09350	COG0840	transmembrane signaling receptor activity
KAM376_09370	COG2610	gluconate transmembrane transporter activity
KAM376_09380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAM376_09390	COG3622	Belongs to the hyi family
KAM376_09400	COG0235	Class ii aldolase
KAM376_09420	COG2084	Dehydrogenase
KAM376_09430	COG1349	DNA-binding transcription factor activity
KAM376_09450	COG2133	pyrroloquinoline quinone binding
KAM376_09480	COG3039	Transposase
KAM376_09550	COG5377	YqaJ viral recombinase family
KAM376_09600	COG1605	Chorismate mutase
KAM376_09600	COG0077	Prephenate dehydratase
KAM376_09650	COG3272	Protein of unknown function (DUF1722)
KAM376_09660	COG0789	Transcriptional regulator
KAM376_09670	COG0415	Belongs to the DNA photolyase family
KAM376_09690	COG0300	oxidoreductase activity
KAM376_09720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KAM376_09770	COG0783	Belongs to the Dps family
KAM376_09780	COG1151	hydroxylamine reductase activity
KAM376_09800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAM376_09830	COG1447	Phosphotransferase system cellobiose-specific component IIA
KAM376_09840	COG2723	6-phospho-beta-galactosidase activity
KAM376_09860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KAM376_09870	COG5297	Belongs to the glycosyl hydrolase family 6
KAM376_09870	COG2273	Hydrolase Family 16
KAM376_09880	COG1472	Belongs to the glycosyl hydrolase 3 family
KAM376_09890	COG0840	transmembrane signaling receptor activity
KAM376_09900	COG2182	Extracellular solute-binding protein
KAM376_09910	COG1609	Transcriptional regulator
KAM376_09960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_09970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_09980	COG0745	RESPONSE REGULATOR receiver
KAM376_09990	COG5000	phosphorelay sensor kinase activity
KAM376_09990	COG5002	protein histidine kinase activity
KAM376_10000	COG0659	secondary active sulfate transmembrane transporter activity
KAM376_10010	COG2771	luxR family
KAM376_10040	COG4104	PAAR repeat-containing protein
KAM376_10070	COG3039	Transposase
KAM376_10100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KAM376_10110	COG1666	GTP binding
KAM376_10130	COG2211	Major facilitator Superfamily
KAM376_10150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAM376_10170	COG2813	Specifically methylates the guanine in position
KAM376_10180	COG0271	Belongs to the BolA IbaG family
KAM376_10190	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM376_10200	COG1805	sodium ion transport
KAM376_10210	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM376_10220	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM376_10230	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM376_10240	COG2871	sodium ion transport
KAM376_10250	COG1477	protein flavinylation
KAM376_10280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM376_10290	COG0840	transmembrane signaling receptor activity
KAM376_10300	COG0583	DNA-binding transcription factor activity
KAM376_10330	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KAM376_10350	COG0473	3-isopropylmalate dehydrogenase activity
KAM376_10360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM376_10370	COG1611	Belongs to the LOG family
KAM376_10400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAM376_10400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAM376_10420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KAM376_10430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KAM376_10490	COG3098	single-species biofilm formation
KAM376_10500	COG0564	pseudouridine synthase activity
KAM376_10540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_10540	COG1263	PTS System
KAM376_10560	COG2171	N-acyltransferase activity
KAM376_10570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KAM376_10580	COG0024	Methionine aminopeptidase
KAM376_10590	COG0052	Belongs to the universal ribosomal protein uS2 family
KAM376_10600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KAM376_10610	COG0528	UMP kinase activity
KAM376_10620	COG0233	cytoplasmic translational termination
KAM376_10630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KAM376_10640	COG0575	Belongs to the CDS family
KAM376_10650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KAM376_10660	COG0750	zinc metalloprotease
KAM376_10690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM376_10700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAM376_10710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM376_10720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM376_10730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KAM376_10750	COG0825	malonyl-CoA metabolic process
KAM376_10780	COG0814	amino acid
KAM376_10790	COG0531	amino acid
KAM376_10810	COG0488	(ABC) transporter
KAM376_10840	COG0037	tRNA processing
KAM376_10850	COG3706	GGDEF domain
KAM376_10920	COG0366	Alpha amylase catalytic
KAM376_10950	COG0463	Glycosyl transferase, family 2
KAM376_10980	COG2989	Protein conserved in bacteria
KAM376_10990	COG3108	Peptidase M15
KAM376_11010	COG2860	membrane
KAM376_11030	COG1196	nuclear chromosome segregation
KAM376_11040	COG3115	cell septum assembly
KAM376_11050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAM376_11070	COG1328	CTP reductase activity
KAM376_11080	COG0602	queuosine metabolic process
KAM376_11130	COG1566	PFAM secretion protein HlyD family protein
KAM376_11150	COG3290	protein histidine kinase activity
KAM376_11180	COG0667	Aldo Keto reductase
KAM376_11190	COG0697	spore germination
KAM376_11220	COG3284	Transcriptional regulator
KAM376_11230	COG3706	GGDEF domain
KAM376_11240	COG0346	lactoylglutathione lyase activity
KAM376_11250	COG0745	RESPONSE REGULATOR receiver
KAM376_11260	COG5002	protein histidine kinase activity
KAM376_11280	COG4783	chaperone-mediated protein folding
KAM376_11300	COG1940	carbohydrate kinase activity
KAM376_11340	COG0545	Peptidyl-prolyl cis-trans isomerase
KAM376_11350	COG1131	(ABC) transporter
KAM376_11380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_11390	COG4597	amino acid ABC transporter
KAM376_11400	COG0765	amino acid transport
KAM376_11410	COG1126	abc transporter atp-binding protein
KAM376_11430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KAM376_11440	COG0678	peroxiredoxin activity
KAM376_11460	COG0019	diaminopimelate decarboxylase activity
KAM376_11470	COG1115	amino acid carrier protein
KAM376_11480	COG2233	PERMEase
KAM376_11510	COG0534	Mate efflux family protein
KAM376_11520	COG2207	Transcriptional regulator
KAM376_11530	COG0281	malic enzyme
KAM376_11590	COG0733	neurotransmitter:sodium symporter activity
KAM376_11600	COG1752	Esterase of the alpha-beta hydrolase superfamily
KAM376_11610	COG3706	GGDEF domain
KAM376_11630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_11640	COG1032	radical SAM domain protein
KAM376_11730	COG0673	inositol 2-dehydrogenase activity
KAM376_11740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KAM376_11750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KAM376_11760	COG0739	heme binding
KAM376_11760	COG0741	lytic transglycosylase activity
KAM376_11760	COG1196	nuclear chromosome segregation
KAM376_11810	COG0788	formyltetrahydrofolate deformylase activity
KAM376_11820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAM376_11840	COG3118	belongs to the thioredoxin family
KAM376_11860	COG0791	NLP P60 protein
KAM376_11870	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KAM376_11900	COG1388	LysM domain
KAM376_11900	COG1376	ErfK ybiS ycfS ynhG family protein
KAM376_11950	COG3561	AntA/AntB antirepressor
KAM376_11980	COG0582	viral genome integration into host DNA
KAM376_11990	COG0784	Response regulator, receiver
KAM376_11990	COG2205	protein histidine kinase activity
KAM376_12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_12020	COG2205	protein histidine kinase activity
KAM376_12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_12030	COG2205	protein histidine kinase activity
KAM376_12040	COG3384	dioxygenase
KAM376_12060	COG1283	sodium-dependent phosphate transmembrane transporter activity
KAM376_12080	COG0531	amino acid
KAM376_12090	COG0531	amino acid
KAM376_12120	COG1012	belongs to the aldehyde dehydrogenase family
KAM376_12130	COG1917	Cupin 2, conserved barrel domain protein
KAM376_12130	COG1396	sequence-specific DNA binding
KAM376_12140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM376_12210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAM376_12210	COG4651	solute:proton antiporter activity
KAM376_12220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAM376_12220	COG4651	solute:proton antiporter activity
KAM376_12230	COG0405	Gamma-glutamyltransferase
KAM376_12250	COG2974	May be involved in recombination
KAM376_12260	COG1247	-acetyltransferase
KAM376_12270	COG0420	3'-5' exonuclease activity
KAM376_12290	COG3038	cytochrome b561
KAM376_12300	COG2190	(PTS) system
KAM376_12320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_12330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KAM376_12340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAM376_12370	COG1720	tRNA m6t6A37 methyltransferase activity
KAM376_12410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KAM376_12420	COG4988	ABC transporter
KAM376_12430	COG0582	viral genome integration into host DNA
KAM376_12530	COG0629	single-stranded DNA binding
KAM376_12540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAM376_12860	COG2003	Belongs to the UPF0758 family
KAM376_13120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAM376_13200	COG0789	Transcriptional regulator
KAM376_13220	COG2608	mercury ion transmembrane transporter activity
KAM376_13230	COG2608	mercury ion transmembrane transporter activity
KAM376_13240	COG0789	Transcriptional regulator
KAM376_13260	COG1120	ATPase activity
KAM376_13290	COG3586	endonuclease activity
KAM376_13320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KAM376_13340	COG0583	DNA-binding transcription factor activity
KAM376_13360	COG0464	growth
KAM376_13400	COG0745	RESPONSE REGULATOR receiver
KAM376_13420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAM376_13450	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KAM376_13460	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KAM376_13480	COG0083	homoserine kinase activity
KAM376_13490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KAM376_13530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KAM376_13550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KAM376_13570	COG3220	belongs to the UPF0276 family
KAM376_13630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM376_13640	COG1289	transmembrane transporter activity
KAM376_13650	COG1763	Mo-molybdopterin cofactor biosynthetic process
KAM376_13660	COG0746	molybdenum cofactor guanylyltransferase activity
KAM376_13670	COG0281	malic enzyme
KAM376_13740	COG3264	Mechanosensitive ion channel
KAM376_13740	COG1196	nuclear chromosome segregation
KAM376_13760	COG2850	peptidyl-arginine hydroxylation
KAM376_13770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KAM376_13780	COG2915	High frequency lysogenization protein hflD homolog
KAM376_13790	COG0482	sulfurtransferase activity
KAM376_13810	COG1187	pseudouridine synthase activity
KAM376_13820	COG0456	acetyltransferase
KAM376_13890	COG0538	isocitrate dehydrogenase activity
KAM376_13910	COG3048	D-serine ammonia-lyase activity
KAM376_13920	COG0583	DNA-binding transcription factor activity
KAM376_13930	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM376_13940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM376_13950	COG2375	cellular response to nickel ion
KAM376_13960	COG1538	Outer membrane efflux protein
KAM376_13970	COG1136	(ABC) transporter
KAM376_13970	COG0577	efflux transmembrane transporter activity
KAM376_13980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_14010	COG0497	DNA recombination
KAM376_14020	COG3706	GGDEF domain
KAM376_14030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KAM376_14050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KAM376_14060	COG0443	Heat shock 70 kDa protein
KAM376_14070	COG0484	heat shock protein binding
KAM376_14140	COG1285	pathogenesis
KAM376_14160	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM376_14180	COG0640	Transcriptional regulator
KAM376_14240	COG0095	Lipoate-protein ligase
KAM376_14270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_14280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_14300	COG0708	Exodeoxyribonuclease III
KAM376_14320	COG0745	RESPONSE REGULATOR receiver
KAM376_14350	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KAM376_14380	COG1846	Transcriptional regulator
KAM376_14420	COG0583	DNA-binding transcription factor activity
KAM376_14430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KAM376_14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAM376_14450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KAM376_14460	COG1845	cytochrome c oxidase, subunit III
KAM376_14470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KAM376_14480	COG0109	protoheme IX farnesyltransferase activity
KAM376_14490	COG2814	Major facilitator Superfamily
KAM376_14500	COG5507	3-demethylubiquinone-9 3-methyltransferase
KAM376_14510	COG2175	clavaminate synthase activity
KAM376_14520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KAM376_14530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KAM376_14540	COG4521	taurine ABC transporter
KAM376_14560	COG0583	DNA-binding transcription factor activity
KAM376_14600	COG1988	membrane-bound metal-dependent
KAM376_14630	COG0159	tryptophan synthase activity
KAM376_14640	COG0133	tryptophan synthase activity
KAM376_14650	COG0134	indole-3-glycerol-phosphate synthase activity
KAM376_14650	COG0135	phosphoribosylanthranilate isomerase activity
KAM376_14660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KAM376_14670	COG0512	Glutamine amidotransferase of anthranilate synthase
KAM376_14670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KAM376_14680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KAM376_14690	COG0613	PHP domain protein
KAM376_14700	COG0009	L-threonylcarbamoyladenylate synthase
KAM376_14720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KAM376_14750	COG1946	Acyl-CoA thioesterase
KAM376_14780	COG1309	transcriptional regulator
KAM376_14790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_14800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_14830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KAM376_14850	COG1960	acyl-CoA dehydrogenase activity
KAM376_14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM376_14880	COG0469	pyruvate kinase activity
KAM376_14890	COG1737	Transcriptional regulator
KAM376_14940	COG1091	dTDP-4-dehydrorhamnose reductase activity
KAM376_14970	COG1083	cytidylyl-transferase
KAM376_14980	COG0483	inositol monophosphate 1-phosphatase activity
KAM376_14990	COG2089	acid synthase
KAM376_15040	COG0438	transferase activity, transferring glycosyl groups
KAM376_15040	COG4641	Protein conserved in bacteria
KAM376_15090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KAM376_15120	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
KAM376_15140	COG3132	Protein of unknown function, DUF480
KAM376_15220	COG1278	Cold shock
KAM376_15290	COG0697	spore germination
KAM376_15310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM376_15350	COG4166	transmembrane transport
KAM376_15360	COG0622	Phosphoesterase
KAM376_15390	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
KAM376_15400	COG0835	chemotaxis
KAM376_15400	COG0784	Response regulator, receiver
KAM376_15410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KAM376_15420	COG1815	bacterial-type flagellum-dependent cell motility
KAM376_15480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KAM376_15490	COG1706	bacterial-type flagellum-dependent cell motility
KAM376_15500	COG1705	Flagellar rod assembly protein muramidase FlgJ
KAM376_15500	COG3951	Flagellar rod assembly protein muramidase FlgJ
KAM376_15530	COG2239	Acts as a magnesium transporter
KAM376_15550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KAM376_15560	COG2716	regulation of RNA biosynthetic process
KAM376_15610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KAM376_15620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KAM376_15630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KAM376_15640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KAM376_15680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KAM376_15690	COG0590	tRNA wobble adenosine to inosine editing
KAM376_15700	COG0573	inorganic phosphate transmembrane transporter activity
KAM376_15710	COG0581	inorganic phosphate transmembrane transporter activity
KAM376_15720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAM376_15730	COG0704	Plays a role in the regulation of phosphate uptake
KAM376_15740	COG1253	flavin adenine dinucleotide binding
KAM376_15760	COG1410	methionine synthase
KAM376_15760	COG0646	methionine synthase
KAM376_15770	COG0531	amino acid
KAM376_15800	COG1126	abc transporter atp-binding protein
KAM376_15810	COG0765	amino acid transport
KAM376_15820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_15830	COG3706	GGDEF domain
KAM376_15840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAM376_15880	COG1785	Belongs to the alkaline phosphatase family
KAM376_15890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KAM376_15900	COG0477	Major facilitator Superfamily
KAM376_15910	COG0123	including yeast histone deacetylase and acetoin utilization protein
KAM376_15930	COG1199	ATP-dependent helicase activity
KAM376_15960	COG1448	Aminotransferase
KAM376_15970	COG0433	COG0433 Predicted ATPase
KAM376_16000	COG0658	competence protein
KAM376_16000	COG2333	competence protein COMEC
KAM376_16010	COG1132	(ABC) transporter
KAM376_16020	COG1663	tetraacyldisaccharide 4'-kinase activity
KAM376_16030	COG2835	tetraacyldisaccharide 4'-kinase activity
KAM376_16040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KAM376_16050	COG2197	response regulator
KAM376_16060	COG0322	excinuclease ABC activity
KAM376_16120	COG0402	S-adenosylhomocysteine deaminase activity
KAM376_16140	COG0604	alcohol dehydrogenase
KAM376_16150	COG1309	transcriptional regulator
KAM376_16160	COG2261	transglycosylase associated protein
KAM376_16170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM376_16190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAM376_16200	COG0215	cysteine-tRNA ligase activity
KAM376_16250	COG2203	Gaf domain
KAM376_16250	COG2199	diguanylate cyclase activity
KAM376_16320	COG2119	membrane
KAM376_16330	COG0023	Translation Initiation Factor
KAM376_16350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KAM376_16400	COG4139	cobalamin transport
KAM376_16410	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
KAM376_16420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM376_16430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KAM376_16440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAM376_16450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAM376_16460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KAM376_16480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KAM376_16490	COG0505	Belongs to the CarA family
KAM376_16500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KAM376_16510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KAM376_16520	COG3706	GGDEF domain
KAM376_16570	COG0513	Belongs to the DEAD box helicase family
KAM376_16590	COG4104	PAAR repeat-containing protein
KAM376_16630	COG0493	'glutamate synthase
KAM376_16640	COG0069	glutamate synthase activity
KAM376_16640	COG0070	glutamate synthase
KAM376_16640	COG0067	glutamate synthase
KAM376_16650	COG1242	4 iron, 4 sulfur cluster binding
KAM376_16750	COG1113	amino acid transport
KAM376_16770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KAM376_16780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAM376_16780	COG0574	Belongs to the PEP-utilizing enzyme family
KAM376_16790	COG1119	ATPase activity
KAM376_16830	COG1464	Belongs to the NlpA lipoprotein family
KAM376_16850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAM376_16860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAM376_16880	COG0101	tRNA pseudouridine synthase activity
KAM376_16890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KAM376_16900	COG0285	dihydrofolate synthase activity
KAM376_16910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KAM376_16920	COG2920	part of a sulfur-relay system
KAM376_16930	COG1289	transmembrane transporter activity
KAM376_16940	COG0670	Belongs to the BI1 family
KAM376_17020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KAM376_17030	COG0840	transmembrane signaling receptor activity
KAM376_17040	COG5001	Diguanylate cyclase
KAM376_17050	COG0564	pseudouridine synthase activity
KAM376_17080	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KAM376_17100	COG0625	glutathione transferase activity
KAM376_17130	COG0367	asparagine synthase
KAM376_17150	COG0647	UMP catabolic process
KAM376_17160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KAM376_17180	COG1902	pentaerythritol trinitrate reductase activity
KAM376_17190	COG1253	flavin adenine dinucleotide binding
KAM376_17210	COG0277	FAD linked oxidase domain protein
KAM376_17210	COG0247	lactate metabolic process
KAM376_17230	COG2050	protein possibly involved in aromatic compounds catabolism
KAM376_17260	COG5001	Diguanylate cyclase
KAM376_17270	COG0583	DNA-binding transcription factor activity
KAM376_17280	COG2814	Major facilitator Superfamily
KAM376_17300	COG2056	Na+-H+ antiporter family
KAM376_17310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM376_17350	COG0483	inositol monophosphate 1-phosphatase activity
KAM376_17370	COG0625	glutathione transferase activity
KAM376_17380	COG0625	glutathione transferase activity
KAM376_17400	COG0601	transmembrane transport
KAM376_17420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM376_17430	COG0444	Belongs to the ABC transporter superfamily
KAM376_17440	COG2814	Major facilitator Superfamily
KAM376_17450	COG2814	Major facilitator Superfamily
KAM376_17480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM376_17490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM376_17500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KAM376_17510	COG0509	glycine decarboxylation via glycine cleavage system
KAM376_17520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAM376_17520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAM376_17560	COG0477	Major facilitator Superfamily
KAM376_17570	COG3634	alkyl hydroperoxide reductase activity
KAM376_17580	COG0450	alkyl hydroperoxide reductase
KAM376_17590	COG0517	IMP dehydrogenase activity
KAM376_17600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KAM376_17610	COG0343	queuine tRNA-ribosyltransferase activity
KAM376_17620	COG1862	Preprotein translocase
KAM376_17630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM376_17640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM376_17650	COG2897	thiosulfate sulfurtransferase activity
KAM376_17670	COG0826	peptidase U32
KAM376_17680	COG0826	peptidase U32
KAM376_17700	COG3154	lipid carrier protein
KAM376_17730	COG1104	cysteine desulfurase activity
KAM376_17740	COG0822	iron-sulfur transferase activity
KAM376_17760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAM376_17770	COG0443	Heat shock 70 kDa protein
KAM376_17780	COG0633	Ferredoxin
KAM376_17800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAM376_17810	COG0105	UTP biosynthetic process
KAM376_17820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KAM376_17840	COG1426	Protein conserved in bacteria
KAM376_17860	COG0124	histidyl-tRNA synthetase
KAM376_17870	COG2976	Protein conserved in bacteria
KAM376_17880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM376_17890	COG1160	GTP binding
KAM376_17900	COG1645	bacterial-type flagellum-dependent swarming motility
KAM376_17910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KAM376_17920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAM376_17920	COG0047	phosphoribosylformylglycinamidine synthase activity
KAM376_17930	COG1007	ATP synthesis coupled electron transport
KAM376_17940	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM376_17960	COG0713	ATP synthesis coupled electron transport
KAM376_17970	COG0839	Belongs to the complex I subunit 6 family
KAM376_17980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM376_17990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KAM376_18000	COG1034	ATP synthesis coupled electron transport
KAM376_18030	COG0649	NAD binding
KAM376_18030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM376_18040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM376_18050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM376_18060	COG1360	Flagellar Motor Protein
KAM376_18070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM376_18090	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KAM376_18110	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KAM376_18130	COG0724	RNA recognition motif
KAM376_18140	COG4989	oxidoreductase activity
KAM376_18190	COG0745	RESPONSE REGULATOR receiver
KAM376_18200	COG0583	DNA-binding transcription factor activity
KAM376_18220	COG3300	MHYT domain
KAM376_18220	COG5001	Diguanylate cyclase
KAM376_18230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KAM376_18290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAM376_18300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KAM376_18310	COG0539	negative regulation of cytoplasmic translation
KAM376_18320	COG0776	regulation of translation
KAM376_18340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KAM376_18380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KAM376_18390	COG0602	queuosine metabolic process
KAM376_18400	COG3530	Putative quorum-sensing-regulated virulence factor
KAM376_18410	COG2096	Adenosyltransferase
KAM376_18420	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM376_18430	COG1757	Na H antiporter
KAM376_18440	COG1435	thymidine kinase activity
KAM376_18490	COG2003	Belongs to the UPF0758 family
KAM376_18540	COG3039	Transposase
KAM376_18550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KAM376_18580	COG1349	DNA-binding transcription factor activity
KAM376_18590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KAM376_18600	COG3550	peptidyl-serine autophosphorylation
KAM376_18730	COG3039	Transposase
KAM376_18750	COG2963	transposase activity
KAM376_18760	COG2197	response regulator
KAM376_18830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KAM376_18880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KAM376_18910	COG3039	Transposase
KAM376_18940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KAM376_18950	COG0626	cystathionine gamma-synthase activity
KAM376_18970	COG2910	NAD(P)H-binding
KAM376_18980	COG0583	DNA-binding transcription factor activity
KAM376_19000	COG2200	EAL domain
KAM376_19010	COG2203	Gaf domain
KAM376_19010	COG2199	diguanylate cyclase activity
KAM376_19020	COG4774	siderophore transport
KAM376_19040	COG0583	DNA-binding transcription factor activity
KAM376_19050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KAM376_19070	COG0617	tRNA 3'-terminal CCA addition
KAM376_19070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KAM376_19070	COG0517	IMP dehydrogenase activity
KAM376_19080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM376_19090	COG3046	protein related to deoxyribodipyrimidine photolyase
KAM376_19110	COG3088	subunit of a heme lyase
KAM376_19110	COG4235	cytochrome complex assembly
KAM376_19120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM376_19130	COG1138	Cytochrome C-type biogenesis protein
KAM376_19140	COG3301	Polysulphide reductase, NrfD
KAM376_19150	COG0437	4 iron, 4 sulfur cluster binding
KAM376_19160	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KAM376_19200	COG0247	lactate metabolic process
KAM376_19210	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KAM376_19220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KAM376_19230	COG3012	SEC-C Motif Domain Protein
KAM376_19240	COG0840	transmembrane signaling receptor activity
KAM376_19250	COG1846	Transcriptional regulator
KAM376_19250	COG1940	carbohydrate kinase activity
KAM376_19260	COG3290	protein histidine kinase activity
KAM376_19270	COG3290	protein histidine kinase activity
KAM376_19280	COG4565	transcriptional regulatory protein
KAM376_19320	COG0739	heme binding
KAM376_19320	COG1196	nuclear chromosome segregation
KAM376_19320	COG0741	lytic transglycosylase activity
KAM376_19330	COG0569	domain protein
KAM376_19330	COG2985	domain, Protein
KAM376_19340	COG0556	nucleotide-excision repair
KAM376_19360	COG0586	Pfam SNARE associated Golgi protein
KAM376_19370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KAM376_19380	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAM376_19390	COG2186	Transcriptional regulator
KAM376_19400	COG2719	SpoVR family
KAM376_19410	COG2718	Belongs to the UPF0229 family
KAM376_19420	COG2766	serine protein kinase
KAM376_19430	COG0514	ATP-dependent DNA helicase (RecQ)
KAM376_19440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KAM376_19450	COG0814	amino acid
KAM376_19510	COG0058	SHG alpha-glucan phosphorylase activity
KAM376_19530	COG0471	metal ion transport
KAM376_19540	COG3118	belongs to the thioredoxin family
KAM376_19560	COG1132	(ABC) transporter
KAM376_19570	COG1132	(ABC) transporter
KAM376_19600	COG2501	S4 domain
KAM376_19620	COG3243	poly(R)-hydroxyalkanoic acid synthase
KAM376_19660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KAM376_19670	COG2329	Antibiotic biosynthesis monooxygenase
KAM376_19740	COG0513	Belongs to the DEAD box helicase family
KAM376_19750	COG0386	Belongs to the glutathione peroxidase family
KAM376_19770	COG1181	Belongs to the D-alanine--D-alanine ligase family
KAM376_19780	COG3148	PFAM DTW domain containing protein
KAM376_19790	COG0730	response to heat
KAM376_19800	COG0583	DNA-binding transcription factor activity
KAM376_19830	COG3593	DNA synthesis involved in DNA repair
KAM376_19850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAM376_19860	COG1011	Hydrolase
KAM376_19870	COG1473	amidohydrolase
KAM376_19890	COG0205	6-phosphofructokinase activity
KAM376_19910	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KAM376_19920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM376_19940	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KAM376_19950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KAM376_20030	COG0675	Transposase, IS605 OrfB family
KAM376_20070	COG2824	Alkylphosphonate utilization operon protein PhnA
KAM376_20160	COG2840	Smr protein MutS2
KAM376_20170	COG2890	protein-(glutamine-N5) methyltransferase activity
KAM376_20180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KAM376_20200	COG0513	Belongs to the DEAD box helicase family
KAM376_20210	COG5654	RES domain protein
KAM376_20230	COG0814	amino acid
KAM376_20240	COG1609	Transcriptional regulator
KAM376_20250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_20250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_20260	COG1105	Belongs to the carbohydrate kinase PfkB family
KAM376_20270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAM376_20270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KAM376_20270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAM376_20280	COG3313	Fe-S protein
KAM376_20290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KAM376_20300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KAM376_20310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM376_20320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM376_20340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM376_20390	COG0675	Transposase, IS605 OrfB family
KAM376_20490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KAM376_20500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KAM376_20510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KAM376_20520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KAM376_20530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KAM376_20540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM376_20540	COG0072	phenylalanine-tRNA ligase activity
KAM376_20550	COG0776	regulation of translation
KAM376_20620	COG3300	MHYT domain
KAM376_20620	COG5001	Diguanylate cyclase
KAM376_20650	COG1609	Transcriptional regulator
KAM376_20660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM376_20670	COG1879	ABC-type sugar transport system periplasmic component
KAM376_20680	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM376_20690	COG1129	ABC transporter
KAM376_20700	COG1869	D-ribose catabolic process
KAM376_20710	COG0625	glutathione transferase activity
KAM376_20740	COG0037	tRNA processing
KAM376_20750	COG0589	response to stress
KAM376_20760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KAM376_20790	COG2217	Heavy metal translocating P-type atpase
KAM376_20810	COG2010	Cytochrome c
KAM376_20840	COG3278	Belongs to the heme-copper respiratory oxidase family
KAM376_20860	COG1956	GAF domain-containing protein
KAM376_20870	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KAM376_20890	COG0308	aminopeptidase N
KAM376_20910	COG2902	Dehydrogenase
KAM376_20920	COG0167	dihydroorotate dehydrogenase activity
KAM376_20940	COG0116	Belongs to the methyltransferase superfamily
KAM376_20940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAM376_20960	COG0488	(ABC) transporter
KAM376_20990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAM376_21000	COG1067	ATP-dependent peptidase activity
KAM376_21020	COG3141	response to X-ray
KAM376_21040	COG2995	paraquat-inducible protein a
KAM376_21050	COG3008	intermembrane lipid transfer
KAM376_21060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM376_21060	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KAM376_21090	COG0084	hydrolase, TatD family'
KAM376_21100	COG0470	DNA polymerase III
KAM376_21110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KAM376_21120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KAM376_21130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAM376_21140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAM376_21150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAM376_21160	COG1028	Short-chain dehydrogenase reductase Sdr
KAM376_21180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAM376_21190	COG0416	fatty acid biosynthetic process
KAM376_21200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KAM376_21210	COG1399	metal-binding, possibly nucleic acid-binding protein
KAM376_21240	COG0564	pseudouridine synthase activity
KAM376_21250	COG1530	ribonuclease E activity
KAM376_21260	COG0306	phosphate transporter
KAM376_21270	COG0717	Belongs to the dCTP deaminase family
KAM376_21280	COG0572	uridine kinase
KAM376_21290	COG0489	protein tyrosine kinase activity
KAM376_21300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM376_21300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM376_21320	COG1254	Belongs to the acylphosphatase family
KAM376_21330	COG0840	transmembrane signaling receptor activity
KAM376_21340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAM376_21370	COG0709	Synthesizes selenophosphate from selenide and ATP
KAM376_21380	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KAM376_21390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAM376_21440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KAM376_21460	COG1643	Atp-dependent helicase
KAM376_21470	COG0517	IMP dehydrogenase activity
KAM376_21470	COG0617	tRNA 3'-terminal CCA addition
KAM376_21470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KAM376_21480	COG2197	response regulator
KAM376_21490	COG3314	Sporulation integral membrane protein YlbJ
KAM376_21510	COG0583	DNA-binding transcription factor activity
KAM376_21520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KAM376_21540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KAM376_21550	COG2832	Protein of unknown function (DUF454)
KAM376_21560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM376_21580	COG0697	spore germination
KAM376_21600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KAM376_21610	COG0318	PFAM AMP-dependent synthetase and ligase
KAM376_21620	COG0596	Alpha beta hydrolase
KAM376_21640	COG1214	PFAM Peptidase M22, glycoprotease
KAM376_21650	COG1199	ATP-dependent helicase activity
KAM376_21670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KAM376_21680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KAM376_21690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KAM376_21700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAM376_21700	COG0131	Imidazoleglycerol-phosphate dehydratase
KAM376_21710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KAM376_21720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KAM376_21730	COG3437	response regulator, receiver
KAM376_21750	COG2205	protein histidine kinase activity
KAM376_21750	COG2198	Histidine kinase
KAM376_21750	COG0784	Response regulator, receiver
KAM376_21760	COG0107	imidazoleglycerol-phosphate synthase activity
KAM376_21770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KAM376_21770	COG0140	phosphoribosyl-ATP diphosphatase activity
KAM376_21790	COG2378	regulation of single-species biofilm formation
KAM376_21800	COG0318	PFAM AMP-dependent synthetase and ligase
KAM376_21810	COG3134	Outer membrane lipoprotein
KAM376_21840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM376_21880	COG4681	YaeQ
KAM376_21900	COG1250	3-hydroxyacyl-CoA dehydrogenase
KAM376_21900	COG1024	Enoyl-CoA hydratase
KAM376_21910	COG0183	Belongs to the thiolase family
KAM376_21920	COG0714	Associated with various cellular activities
KAM376_21980	COG1595	DNA-templated transcription, initiation
KAM376_22000	COG2067	long-chain fatty acid transport protein
KAM376_22010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KAM376_22040	COG1301	dicarboxylic acid transport
KAM376_22050	COG3123	guanosine phosphorylase activity
KAM376_22060	COG1760	l-serine dehydratase
KAM376_22070	COG1760	l-serine dehydratase
KAM376_22080	COG2951	lytic endotransglycosylase activity
KAM376_22090	COG3100	YcgL domain-containing protein
KAM376_22100	COG0850	regulation of cytokinetic process
KAM376_22110	COG2894	cell division
KAM376_22120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KAM376_22130	COG3099	Belongs to the UPF0263 family
KAM376_22140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KAM376_22170	COG2996	Protein conserved in bacteria
KAM376_22180	COG0675	Transposase, IS605 OrfB family
KAM376_22240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KAM376_22250	COG0697	spore germination
KAM376_22260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KAM376_22270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM376_22300	COG0307	riboflavin synthase, alpha
KAM376_22320	COG0534	Mate efflux family protein
KAM376_22330	COG0417	DNA replication proofreading
KAM376_22360	COG1560	Kdo2-lipid A biosynthetic process
KAM376_22370	COG1560	Kdo2-lipid A biosynthetic process
KAM376_22390	COG0583	DNA-binding transcription factor activity
KAM376_22400	COG0673	inositol 2-dehydrogenase activity
KAM376_22410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KAM376_22440	COG0583	DNA-binding transcription factor activity
KAM376_22460	COG2723	6-phospho-beta-galactosidase activity
KAM376_22470	COG0583	DNA-binding transcription factor activity
KAM376_22490	COG0243	molybdopterin cofactor binding
KAM376_22500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KAM376_22530	COG0583	DNA-binding transcription factor activity
KAM376_22540	COG1879	ABC-type sugar transport system periplasmic component
KAM376_22550	COG1129	ABC transporter
KAM376_22560	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM376_22570	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM376_22590	COG4974	Belongs to the 'phage' integrase family
KAM376_22620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM376_22800	COG0730	response to heat
KAM376_22820	COG1028	Short-chain dehydrogenase reductase Sdr
KAM376_22840	COG1024	Enoyl-CoA hydratase
KAM376_22850	COG1024	Enoyl-CoA hydratase
KAM376_22860	COG1960	acyl-CoA dehydrogenase activity
KAM376_22880	COG1960	acyl-CoA dehydrogenase activity
KAM376_22890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KAM376_22900	COG1024	Enoyl-CoA hydratase
KAM376_22950	COG1584	GPR1 FUN34 yaaH family protein
KAM376_22960	COG3228	Belongs to the MtfA family
KAM376_22980	COG1115	amino acid carrier protein
KAM376_22990	COG1024	Enoyl-CoA hydratase
KAM376_23020	COG3162	membrane
KAM376_23030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAM376_23040	COG0488	(ABC) transporter
KAM376_23050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAM376_23060	COG0776	regulation of translation
KAM376_23070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KAM376_23080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KAM376_23090	COG0740	serine-type endopeptidase activity
KAM376_23100	COG0544	peptidyl-prolyl cis-trans isomerase activity
KAM376_23140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KAM376_23150	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAM376_23160	COG1136	(ABC) transporter
KAM376_23170	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAM376_23190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KAM376_23200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KAM376_23220	COG0697	spore germination
KAM376_23240	COG2062	phosphohistidine phosphatase, SixA
KAM376_23280	COG1846	Transcriptional regulator
KAM376_23340	COG0519	Catalyzes the synthesis of GMP from XMP
KAM376_23340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAM376_23350	COG0517	IMP dehydrogenase activity
KAM376_23350	COG0516	GMP reductase activity
KAM376_23370	COG1874	Beta-galactosidase
KAM376_23370	COG0366	Alpha amylase catalytic
KAM376_23400	COG1570	exodeoxyribonuclease VII activity
KAM376_23420	COG2885	chlorophyll binding
KAM376_23460	COG2154	pterin-4-alpha-carbinolamine dehydratase
KAM376_23480	COG3768	UPF0283 membrane protein
KAM376_23490	COG3106	COG3106 Predicted ATPase
KAM376_23520	COG1842	Phage shock protein A
KAM376_23530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KAM376_23560	COG4171	peptide transport system, permease
KAM376_23580	COG4172	Belongs to the ABC transporter superfamily
KAM376_23600	COG1609	Transcriptional regulator
KAM376_23610	COG1263	PTS System
KAM376_23610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_23620	COG2723	6-phospho-beta-galactosidase activity
KAM376_23630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KAM376_23640	COG1286	toxin biosynthetic process
KAM376_23650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KAM376_23660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KAM376_23670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KAM376_23680	COG1674	ftsk spoiiie
KAM376_23680	COG0531	amino acid
KAM376_23700	COG0686	Belongs to the AlaDH PNT family
KAM376_23710	COG0492	ferredoxin-NADP+ reductase activity
KAM376_23720	COG3706	GGDEF domain
KAM376_23730	COG3134	Outer membrane lipoprotein
KAM376_23740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KAM376_23750	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KAM376_23760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KAM376_23770	COG0542	response to heat
KAM376_23780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KAM376_23790	COG1278	Cold shock
KAM376_23800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAM376_23830	COG1944	ATP diphosphatase activity
KAM376_23840	COG2116	formate transmembrane transporter activity
KAM376_23850	COG1882	Formate acetyltransferase
KAM376_23860	COG2983	Belongs to the UPF0260 family
KAM376_23880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KAM376_23890	COG0045	succinate-CoA ligase (ADP-forming) activity
KAM376_23900	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAM376_23910	COG0567	Dehydrogenase, E1 component
KAM376_23940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KAM376_23950	COG2009	succinate dehydrogenase
KAM376_23990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAM376_24000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM376_24000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KAM376_24020	COG3069	C4-dicarboxylate transmembrane transporter activity
KAM376_24050	COG1451	nucleotide metabolic process
KAM376_24080	COG0254	rRNA binding
KAM376_24090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KAM376_24110	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM376_24120	COG1129	ABC transporter
KAM376_24130	COG1879	ABC-type sugar transport system periplasmic component
KAM376_24140	COG1069	ribulokinase activity
KAM376_24160	COG2160	L-arabinose isomerase activity
KAM376_24170	COG0583	DNA-binding transcription factor activity
KAM376_24180	COG0436	Aminotransferase
KAM376_24190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM376_24220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KAM376_24220	COG0392	lysyltransferase activity
KAM376_24230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KAM376_24270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_24270	COG1263	PTS System
KAM376_24280	COG1874	Beta-galactosidase
KAM376_24290	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KAM376_24300	COG3833	ABC-type maltose transport systems, permease component
KAM376_24310	COG1175	transmembrane transport
KAM376_24320	COG2182	Extracellular solute-binding protein
KAM376_24370	COG4580	involved in the transport of maltose and maltodextrins
KAM376_24380	COG1609	Transcriptional regulator
KAM376_24390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAM376_24400	COG1085	galactose-1-phosphate uridylyltransferase
KAM376_24410	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KAM376_24470	COG3039	Transposase
KAM376_24490	COG2925	Exonuclease
KAM376_24510	COG3345	alpha-galactosidase
KAM376_24520	COG1380	Effector of murein hydrolase LrgA
KAM376_24530	COG1346	cytolysis
KAM376_24540	COG0295	cytidine deaminase activity
KAM376_24550	COG1022	Amp-dependent synthetase and ligase
KAM376_24580	COG0861	Integral membrane protein TerC family
KAM376_24590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM376_24600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KAM376_24610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KAM376_24690	COG4771	TonB-dependent receptor
KAM376_24700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM376_24710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM376_24720	COG1120	ATPase activity
KAM376_24750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAM376_24770	COG1028	Short-chain dehydrogenase reductase Sdr
KAM376_24780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAM376_24790	COG1535	isochorismatase
KAM376_24790	COG3433	isochorismatase activity
KAM376_24800	COG1021	2,3-dihydroxybenzoate-AMP ligase
KAM376_24850	COG5001	Diguanylate cyclase
KAM376_24850	COG3300	MHYT domain
KAM376_24880	COG0840	transmembrane signaling receptor activity
KAM376_24890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM376_24900	COG3788	relative of glutathione S-transferase, MAPEG superfamily
KAM376_24910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KAM376_24920	COG0563	adenylate kinase activity
KAM376_24930	COG0326	Molecular chaperone. Has ATPase activity
KAM376_24940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KAM376_24950	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KAM376_24960	COG0298	carbon dioxide binding
KAM376_24980	COG0309	Hydrogenase expression formation protein (HypE)
KAM376_24990	COG0375	protein maturation
KAM376_25010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KAM376_25020	COG3842	ATPase activity
KAM376_25040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM376_25050	COG0601	transmembrane transport
KAM376_25070	COG1773	rubredoxin
KAM376_25080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KAM376_25090	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
KAM376_25100	COG5557	Pfam Polysulphide reductase, NrfD
KAM376_25110	COG0437	4 iron, 4 sulfur cluster binding
KAM376_25120	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
KAM376_25150	COG3039	Transposase
KAM376_25170	COG3209	COG3209 Rhs family protein
KAM376_25190	COG3501	Rhs element vgr protein
KAM376_25220	COG0659	secondary active sulfate transmembrane transporter activity
KAM376_25230	COG2308	Evidence 4 Homologs of previously reported genes of
KAM376_25300	COG0672	)-iron permease
KAM376_25350	COG2814	Major facilitator Superfamily
KAM376_25400	COG1136	(ABC) transporter
KAM376_25410	COG0577	efflux transmembrane transporter activity
KAM376_25470	COG1139	Iron-sulfur cluster binding protein
KAM376_25480	COG0247	lactate metabolic process
KAM376_25490	COG1620	l-lactate permease
KAM376_25500	COG0583	DNA-binding transcription factor activity
KAM376_25550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM376_25560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAM376_25560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KAM376_25570	COG0527	aspartate kinase activity
KAM376_25590	COG1368	sulfuric ester hydrolase activity
KAM376_25600	COG1619	proteins homologs of microcin C7 resistance protein MccF
KAM376_25620	COG0393	Putative heavy-metal-binding
KAM376_25630	COG1252	NADH dehydrogenase
KAM376_25640	COG3150	esterase
KAM376_25650	COG1164	Oligoendopeptidase f
KAM376_25660	COG1164	Oligoendopeptidase f
KAM376_25670	COG2354	Protein conserved in bacteria
KAM376_25700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM376_25710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM376_25780	COG0537	adenosine 5'-monophosphoramidase activity
KAM376_25810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAM376_25850	COG1301	dicarboxylic acid transport
KAM376_25870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAM376_25880	COG0861	Integral membrane protein TerC family
KAM376_25900	COG0444	Belongs to the ABC transporter superfamily
KAM376_25910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM376_25920	COG0601	transmembrane transport
KAM376_25940	COG2095	MarC family integral membrane protein
KAM376_25950	COG1012	belongs to the aldehyde dehydrogenase family
KAM376_25950	COG1454	alcohol dehydrogenase
KAM376_25970	COG3275	phosphorelay sensor kinase activity
KAM376_25980	COG3279	Response regulator of the LytR AlgR family
KAM376_25990	COG1966	Carbon starvation protein
KAM376_26010	COG1566	PFAM secretion protein HlyD family protein
KAM376_26020	COG1061	Type III restriction enzyme res subunit
KAM376_26030	COG2027	D-alanyl-D-alanine carboxypeptidase
KAM376_26040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAM376_26060	COG0436	Aminotransferase
KAM376_26070	COG1288	antiporter activity
KAM376_26080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAM376_26120	COG0697	spore germination
KAM376_26130	COG4657	Part of a membrane complex involved in electron transport
KAM376_26140	COG2878	Part of a membrane complex involved in electron transport
KAM376_26160	COG4658	electron transport chain
KAM376_26170	COG4659	FMN binding
KAM376_26180	COG4660	Part of a membrane complex involved in electron transport
KAM376_26190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KAM376_26200	COG0346	lactoylglutathione lyase activity
KAM376_26230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KAM376_26250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KAM376_26260	COG1086	Polysaccharide biosynthesis protein
KAM376_26270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KAM376_26290	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KAM376_26300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KAM376_26330	COG2089	acid synthase
KAM376_26410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM376_26420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM376_26450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM376_26450	COG0301	tRNA thio-modification
KAM376_26470	COG4953	penicillin-binding protein 1C
KAM376_26480	COG2373	Large extracellular alpha-helical protein
KAM376_26490	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM376_26500	COG5001	Diguanylate cyclase
KAM376_26520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KAM376_26540	COG4160	amino acid transport
KAM376_26560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_26580	COG2431	L-lysine efflux transmembrane transporter activity
KAM376_26590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KAM376_26600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_26650	COG1393	Belongs to the ArsC family
KAM376_26670	COG4783	chaperone-mediated protein folding
KAM376_26680	COG0425	Belongs to the sulfur carrier protein TusA family
KAM376_26710	COG0596	Alpha beta hydrolase
KAM376_26730	COG3842	ATPase activity
KAM376_26740	COG3833	ABC-type maltose transport systems, permease component
KAM376_26750	COG1175	transmembrane transport
KAM376_26770	COG3081	Nucleoid-associated protein
KAM376_26780	COG3082	Protein of unknown function (DUF1414)
KAM376_26790	COG3083	sulfuric ester hydrolase activity
KAM376_26800	COG4771	TonB-dependent receptor
KAM376_26810	COG1770	oligopeptidase
KAM376_26850	COG4574	serine-type endopeptidase inhibitor activity
KAM376_26860	COG3085	chromosome segregation
KAM376_26880	COG1605	Chorismate mutase
KAM376_26880	COG0287	Prephenate dehydrogenase
KAM376_26890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM376_26900	COG0584	glycerophosphoryl diester phosphodiesterase
KAM376_26930	COG1349	DNA-binding transcription factor activity
KAM376_26940	COG2271	Major facilitator Superfamily
KAM376_26950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KAM376_26960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KAM376_26970	COG0583	DNA-binding transcription factor activity
KAM376_27010	COG0656	L-ascorbic acid biosynthetic process
KAM376_27020	COG2814	Major facilitator Superfamily
KAM376_27030	COG1294	oxidase, subunit
KAM376_27050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM376_27070	COG2979	Protein of unknown function (DUF533)
KAM376_27110	COG0583	DNA-binding transcription factor activity
KAM376_27140	COG2807	transmembrane transport
KAM376_27150	COG1187	pseudouridine synthase activity
KAM376_27160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KAM376_27200	COG1061	Type III restriction enzyme res subunit
KAM376_27270	COG1166	arginine decarboxylase activity
KAM376_27280	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAM376_27310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KAM376_27340	COG0583	DNA-binding transcription factor activity
KAM376_27360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KAM376_27370	COG0840	transmembrane signaling receptor activity
KAM376_27380	COG0840	transmembrane signaling receptor activity
KAM376_27390	COG0302	gtp cyclohydrolase
KAM376_27410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAM376_27440	COG2267	carboxylic ester hydrolase activity
KAM376_27450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KAM376_27480	COG0314	molybdopterin synthase activity
KAM376_27490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KAM376_27500	COG0315	cyclic pyranopterin monophosphate synthase activity
KAM376_27510	COG0521	Mo-molybdopterin cofactor biosynthetic process
KAM376_27520	COG3005	denitrification pathway
KAM376_27540	COG0348	domain, Protein
KAM376_27550	COG0437	4 iron, 4 sulfur cluster binding
KAM376_27560	COG0243	molybdopterin cofactor binding
KAM376_27580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM376_27580	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM376_27590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KAM376_27600	COG3850	Histidine kinase
KAM376_27610	COG2197	response regulator
KAM376_27660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KAM376_27680	COG0121	glutamine amidotransferase
KAM376_27690	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAM376_27700	COG1960	acyl-CoA dehydrogenase activity
KAM376_27710	COG0784	Response regulator, receiver
KAM376_27710	COG3437	response regulator, receiver
KAM376_27730	COG0784	Response regulator, receiver
KAM376_27730	COG3437	response regulator, receiver
KAM376_27750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM376_27760	COG0328	RNA-DNA hybrid ribonuclease activity
KAM376_27770	COG2226	methyltransferase
KAM376_27780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAM376_27790	COG0741	lytic transglycosylase activity
KAM376_27790	COG1388	LysM domain
KAM376_27820	COG1607	acyl-coa hydrolase
KAM376_27850	COG0741	lytic transglycosylase activity
KAM376_27870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KAM376_27900	COG0729	surface antigen
KAM376_27920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAM376_27940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KAM376_27950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM376_27960	COG4134	Bacterial extracellular solute-binding protein
KAM376_27980	COG4136	ATPase activity
KAM376_27990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KAM376_28000	COG2951	lytic endotransglycosylase activity
KAM376_28010	COG1846	Transcriptional regulator
KAM376_28030	COG0033	Phosphoglucomutase
KAM376_28040	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KAM376_28060	COG0596	Alpha beta hydrolase
KAM376_28090	COG0716	FMN binding
KAM376_28110	COG0735	belongs to the Fur family
KAM376_28120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM376_28140	COG2190	(PTS) system
KAM376_28140	COG1263	PTS System
KAM376_28140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_28150	COG0363	glucosamine-6-phosphate deaminase activity
KAM376_28160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KAM376_28170	COG1846	Transcriptional regulator
KAM376_28170	COG1940	carbohydrate kinase activity
KAM376_28180	COG2194	sulfuric ester hydrolase activity
KAM376_28190	COG0217	transcriptional regulatory protein
KAM376_28200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KAM376_28210	COG1801	Protein of unknown function DUF72
KAM376_28220	COG4106	trans-aconitate 2-methyltransferase activity
KAM376_28230	COG0500	methyltransferase
KAM376_28270	COG0583	DNA-binding transcription factor activity
KAM376_28280	COG0791	NLP P60 protein
KAM376_28310	COG1309	transcriptional regulator
KAM376_28330	COG1454	alcohol dehydrogenase
KAM376_28380	COG0534	Mate efflux family protein
KAM376_28400	COG2841	Protein conserved in bacteria
KAM376_28410	COG0674	pyruvate-flavodoxin oxidoreductase activity
KAM376_28410	COG1013	pyruvate-flavodoxin oxidoreductase activity
KAM376_28410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KAM376_28410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KAM376_28430	COG0633	Ferredoxin
KAM376_28430	COG0633	Ferredoxin
KAM376_28430	COG3217	Mosc domain protein beta barrel domain protein
KAM376_28430	COG3217	Mosc domain protein beta barrel domain protein
KAM376_28440	COG0501	Belongs to the peptidase M48B family
KAM376_28450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KAM376_28470	COG0156	8-amino-7-oxononanoate synthase activity
KAM376_28480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAM376_28530	COG0017	Asparaginyl-tRNA synthetase
KAM376_28540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAM376_28560	COG1473	amidohydrolase
KAM376_28570	COG3069	C4-dicarboxylate transmembrane transporter activity
KAM376_28590	COG1393	Belongs to the ArsC family
KAM376_28600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KAM376_28610	COG1876	peptidase activity
KAM376_28630	COG3263	regulation of cellular component size
KAM376_28650	COG1280	lysine exporter protein (LysE YggA)
KAM376_28710	COG1957	nucleoside hydrolase
KAM376_28740	COG1454	alcohol dehydrogenase
KAM376_28750	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM376_28760	COG0702	epimerase
KAM376_28770	COG2914	Belongs to the UPF0125 (RnfH) family
KAM376_28780	COG2867	negative regulation of translational initiation
KAM376_28790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KAM376_29150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM376_29390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM376_29580	COG0582	viral genome integration into host DNA
KAM376_29590	COG5642	Protein of unknown function (DUF2384)
KAM376_29690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAM376_29700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM376_29720	COG0758	DNA mediated transformation
KAM376_29730	COG0514	ATP-dependent DNA helicase (RecQ)
KAM376_29820	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM376_29830	COG3039	Transposase
KAM376_29850	COG3039	Transposase
KAM376_29860	COG3311	Transcriptional regulator
KAM376_29890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM376_29900	COG0800	Aldolase
KAM376_29930	COG3153	acetyltransferase
KAM376_29990	COG0259	pyridoxamine-phosphate oxidase activity
KAM376_30020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM376_30020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM376_30030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KAM376_30060	COG0457	Tetratricopeptide repeat
KAM376_30080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM376_30090	COG1138	Cytochrome C-type biogenesis protein
KAM376_30100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KAM376_30110	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM376_30120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM376_30130	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM376_30160	COG0835	chemotaxis
KAM376_30180	COG1192	Involved in chromosome partitioning
KAM376_30190	COG1360	Flagellar Motor Protein
KAM376_30200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM376_30210	COG2201	protein-glutamate methylesterase activity
KAM376_30220	COG0643	Histidine kinase
KAM376_30220	COG0784	Response regulator, receiver
KAM376_30220	COG2198	Histidine kinase
KAM376_30230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KAM376_30280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KAM376_30300	COG1684	flagellar biosynthetic protein fliR
KAM376_30410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KAM376_30430	COG1677	Flagellar hook-basal body complex protein FliE
KAM376_30460	COG1393	Belongs to the ArsC family
KAM376_30470	COG0798	PFAM Bile acid sodium symporter
KAM376_30480	COG0640	Transcriptional regulator
KAM376_30510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAM376_30540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM376_30550	COG0444	Belongs to the ABC transporter superfamily
KAM376_30560	COG4608	Belongs to the ABC transporter superfamily
KAM376_30590	COG2971	BadF BadG BcrA BcrD
KAM376_30610	COG0840	transmembrane signaling receptor activity
KAM376_30650	COG3724	N-succinylarginine dihydrolase activity
KAM376_30660	COG0616	signal peptide processing
KAM376_30670	COG1028	Short-chain dehydrogenase reductase Sdr
KAM376_30680	COG0583	DNA-binding transcription factor activity
KAM376_30700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KAM376_30720	COG0583	DNA-binding transcription factor activity
KAM376_30730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KAM376_30740	COG1881	PFAM PEBP family protein
KAM376_30760	COG3408	Glycogen debranching enzyme
KAM376_30760	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KAM376_30770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAM376_30780	COG0739	heme binding
KAM376_30790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KAM376_30830	COG2801	Transposase and inactivated derivatives
KAM376_30850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KAM376_30870	COG3091	SprT-like family
KAM376_30890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KAM376_30900	COG0189	ligase activity
KAM376_30920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAM376_30960	COG1115	amino acid carrier protein
KAM376_30970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KAM376_31000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KAM376_31020	COG1301	dicarboxylic acid transport
KAM376_31030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KAM376_31040	COG2912	Transglutaminase-like superfamily
KAM376_31060	COG2890	protein-(glutamine-N5) methyltransferase activity
KAM376_31070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KAM376_31080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KAM376_31090	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KAM376_31100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KAM376_31110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KAM376_31120	COG0193	aminoacyl-tRNA hydrolase activity
KAM376_31130	COG0012	GTP binding
KAM376_31140	COG0471	metal ion transport
KAM376_31140	COG0490	domain, Protein
KAM376_31160	COG0657	acetylesterase activity
KAM376_31190	COG2814	Major facilitator Superfamily
KAM376_31200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM376_31230	COG1012	belongs to the aldehyde dehydrogenase family
KAM376_31250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KAM376_31280	COG0180	Tryptophanyl-tRNA synthetase
KAM376_31290	COG0546	phosphoglycolate phosphatase activity
KAM376_31300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KAM376_31310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KAM376_31330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KAM376_31340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KAM376_31400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAM376_31410	COG0583	DNA-binding transcription factor activity
KAM376_31440	COG0583	DNA-binding transcription factor activity
KAM376_31470	COG0739	heme binding
KAM376_31490	COG1511	domain protein
KAM376_31490	COG3264	Mechanosensitive ion channel
KAM376_31500	COG0584	glycerophosphoryl diester phosphodiesterase
KAM376_31520	COG1053	succinate dehydrogenase
KAM376_31530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KAM376_31540	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KAM376_31550	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KAM376_31580	COG3214	Protein conserved in bacteria
KAM376_31590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM376_31630	COG0300	oxidoreductase activity
KAM376_31670	COG4067	protein conserved in archaea
KAM376_31670	COG0189	ligase activity
KAM376_31680	COG0516	GMP reductase activity
KAM376_31700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAM376_31710	COG2011	ABC-type metal ion transport system permease component
KAM376_31720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAM376_31730	COG1464	Belongs to the NlpA lipoprotein family
KAM376_31760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAM376_31780	COG2199	diguanylate cyclase activity
KAM376_31800	COG2199	diguanylate cyclase activity
KAM376_31810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM376_31840	COG1278	Cold shock
KAM376_31850	COG1335	isochorismatase
KAM376_31860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM376_31870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAM376_31880	COG1702	phosphate starvation-inducible protein PhoH
KAM376_31890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KAM376_31900	COG4535	Mg2 and Co2 transporter CorC
KAM376_31910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KAM376_31920	COG2888	peptidyl-tyrosine sulfation
KAM376_31930	COG0495	leucyl-tRNA aminoacylation
KAM376_31980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KAM376_31990	COG0799	negative regulation of ribosome biogenesis
KAM376_32000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KAM376_32010	COG0768	penicillin binding
KAM376_32020	COG0772	Belongs to the SEDS family
KAM376_32030	COG2951	lytic endotransglycosylase activity
KAM376_32040	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KAM376_32050	COG1686	Belongs to the peptidase S11 family
KAM376_32060	COG2921	Belongs to the UPF0250 family
KAM376_32070	COG0321	lipoyl(octanoyl) transferase activity
KAM376_32080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KAM376_32100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM376_32130	COG0789	Transcriptional regulator
KAM376_32160	COG1970	mechanosensitive ion channel activity
KAM376_32170	COG4974	Belongs to the 'phage' integrase family
KAM376_32190	COG0312	modulator of DNA gyrase
KAM376_32200	COG0312	modulator of DNA gyrase
KAM376_32230	COG0826	peptidase U32
KAM376_32240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM376_32250	COG1422	Protein of unknown function (DUF1090)
KAM376_32260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KAM376_32270	COG2211	Major facilitator Superfamily
KAM376_32280	COG1185	polyribonucleotide nucleotidyltransferase activity
KAM376_32290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KAM376_32300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KAM376_32310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KAM376_32320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KAM376_32330	COG0195	Participates in both transcription termination and antitermination
KAM376_32340	COG0779	Required for maturation of 30S ribosomal subunits
KAM376_32350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAM376_32360	COG0149	triose-phosphate isomerase activity
KAM376_32380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KAM376_32390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KAM376_32410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KAM376_32420	COG1534	Rna-binding protein
KAM376_32450	COG1360	Flagellar Motor Protein
KAM376_32460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM376_32470	COG1722	exodeoxyribonuclease VII activity
KAM376_32480	COG0142	geranyltranstransferase activity
KAM376_32490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KAM376_32500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM376_32510	COG0601	transmembrane transport
KAM376_32530	COG4172	Belongs to the ABC transporter superfamily
KAM376_32540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KAM376_32550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KAM376_32560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM376_32570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KAM376_32600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAM376_32600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAM376_32610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KAM376_32630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAM376_32650	COG3381	protein complex oligomerization
KAM376_32680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAM376_32690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KAM376_32700	COG0511	ligase activity, forming carbon-carbon bonds
KAM376_32710	COG0439	Biotin carboxylase
KAM376_32720	COG3924	membrane
KAM376_32730	COG4145	pantothenate transmembrane transporter activity
KAM376_32740	COG2190	(PTS) system
KAM376_32740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_32740	COG1263	PTS System
KAM376_32750	COG0583	DNA-binding transcription factor activity
KAM376_32760	COG0604	alcohol dehydrogenase
KAM376_32770	COG2264	protein methyltransferase activity
KAM376_32780	COG0110	maltose O-acetyltransferase activity
KAM376_32810	COG0778	Nitroreductase
KAM376_32820	COG1902	pentaerythritol trinitrate reductase activity
KAM376_32820	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM376_32830	COG0616	signal peptide processing
KAM376_32870	COG3139	Protein of unknown function (DUF1315)
KAM376_32880	COG0252	asparaginase activity
KAM376_32890	COG0786	glutamate:sodium symporter activity
KAM376_32910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KAM376_32920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KAM376_32930	COG0384	phenazine biosynthesis protein PhzF
KAM376_32940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KAM376_32950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM376_32960	COG0175	sulfate reduction
KAM376_32970	COG2113	Glycine betaine
KAM376_32980	COG4176	ABC-type proline glycine betaine transport system permease component
KAM376_32990	COG4175	Glycine betaine
KAM376_33010	COG3610	response to peptide
KAM376_33020	COG2966	Psort location CytoplasmicMembrane, score
KAM376_33040	COG0521	Mo-molybdopterin cofactor biosynthetic process
KAM376_33080	COG2313	pseudouridylate synthase activity
KAM376_33090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM376_33100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM376_33100	COG2146	nitrite reductase [NAD(P)H] activity
KAM376_33110	COG2146	nitrite reductase [NAD(P)H] activity
KAM376_33110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM376_33120	COG1116	anion transmembrane transporter activity
KAM376_33130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KAM376_33140	COG1116	anion transmembrane transporter activity
KAM376_33140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KAM376_33160	COG1648	precorrin-2 dehydrogenase activity
KAM376_33160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM376_33170	COG0243	molybdopterin cofactor binding
KAM376_33230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KAM376_33260	COG1073	alpha beta
KAM376_33270	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KAM376_33280	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAM376_33300	COG4608	Belongs to the ABC transporter superfamily
KAM376_33310	COG0444	Belongs to the ABC transporter superfamily
KAM376_33330	COG4239	(ABC) transporter, permease
KAM376_33340	COG4174	ABC transporter (Permease)
KAM376_33350	COG4206	TonB-dependent receptor
KAM376_33370	COG0811	peptide transport
KAM376_33380	COG0811	peptide transport
KAM376_33390	COG0848	biopolymer transport protein
KAM376_33440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM376_33450	COG0840	transmembrane signaling receptor activity
KAM376_33470	COG1278	Cold shock
KAM376_33480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KAM376_33490	COG1162	GTPase activity
KAM376_33500	COG0688	phosphatidylethanolamine metabolic process
KAM376_33510	COG4628	conserved protein (DUF2132)
KAM376_33550	COG3300	MHYT domain
KAM376_33550	COG5001	Diguanylate cyclase
KAM376_33560	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KAM376_33630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KAM376_33630	COG0784	Response regulator, receiver
KAM376_33690	COG4974	Belongs to the 'phage' integrase family
KAM376_33740	COG2801	Transposase and inactivated derivatives
KAM376_33750	COG2963	transposase activity
KAM376_33760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KAM376_33810	COG0582	viral genome integration into host DNA
KAM376_33840	COG1132	(ABC) transporter
KAM376_33860	COG2897	thiosulfate sulfurtransferase activity
KAM376_33870	COG2066	Belongs to the glutaminase family
KAM376_33880	COG3171	Protein conserved in bacteria
KAM376_33890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KAM376_33900	COG4935	Belongs to the peptidase S8 family
KAM376_33900	COG2234	aminopeptidase activity
KAM376_33910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM376_33920	COG2200	EAL domain
KAM376_33930	COG1090	epimerase
KAM376_33940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KAM376_33950	COG4181	ATPase activity
KAM376_33960	COG2755	lipolytic protein G-D-S-L family
KAM376_33970	COG0835	chemotaxis
KAM376_33970	COG0784	Response regulator, receiver
KAM376_33990	COG0517	IMP dehydrogenase activity
KAM376_33990	COG0516	GMP reductase activity
KAM376_34000	COG0488	(ABC) transporter
KAM376_34020	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KAM376_34100	COG0789	Transcriptional regulator
KAM376_34120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAM376_34140	COG0668	transmembrane transport
KAM376_34160	COG2731	YhcH YjgK YiaL family protein
KAM376_34180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM376_34190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM376_34210	COG3227	Zinc metalloprotease (Elastase)
KAM376_34220	COG0583	DNA-binding transcription factor activity
KAM376_34230	COG0477	Major facilitator Superfamily
KAM376_34250	COG2985	domain, Protein
KAM376_34250	COG0569	domain protein
KAM376_34260	COG1272	protein, Hemolysin III
KAM376_34270	COG0076	glutamate decarboxylase activity
KAM376_34280	COG2917	probably involved in intracellular septation
KAM376_34290	COG2350	Protein conserved in bacteria
KAM376_34310	COG1555	photosystem II stabilization
KAM376_34320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KAM376_34330	COG3104	oligopeptide transport
KAM376_34340	COG0745	RESPONSE REGULATOR receiver
KAM376_34400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_34420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM376_34430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KAM376_34440	COG1280	lysine exporter protein (LysE YggA)
KAM376_34450	COG0316	Belongs to the HesB IscA family
KAM376_34470	COG0038	chloride channel
KAM376_34480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KAM376_34510	COG0671	phosphoesterase, PA-phosphatase related
KAM376_34530	COG0583	DNA-binding transcription factor activity
KAM376_34560	COG0346	lactoylglutathione lyase activity
KAM376_34570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KAM376_34580	COG1643	Atp-dependent helicase
KAM376_34600	COG1489	DNA binding
KAM376_34610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KAM376_34620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM376_34640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KAM376_34650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KAM376_34660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KAM376_34680	COG0842	Transport permease protein
KAM376_34690	COG1131	(ABC) transporter
KAM376_34720	COG0163	prenyltransferase activity
KAM376_34730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAM376_34740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KAM376_34770	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KAM376_34800	COG1136	(ABC) transporter
KAM376_34840	COG0840	transmembrane signaling receptor activity
KAM376_34880	COG0529	Catalyzes the synthesis of activated sulfate
KAM376_34890	COG3273	potassium ion transport
KAM376_34890	COG0471	metal ion transport
KAM376_34900	COG2895	sulfate adenylyltransferase (ATP) activity
KAM376_34910	COG0175	sulfate reduction
KAM376_34920	COG1648	precorrin-2 dehydrogenase activity
KAM376_34920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM376_34930	COG0330	HflC and HflK could
KAM376_34940	COG1585	Membrane protein implicated in regulation of membrane protease activity
KAM376_34960	COG0673	inositol 2-dehydrogenase activity
KAM376_34980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KAM376_34990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAM376_35000	COG3036	rescue of stalled ribosome
KAM376_35030	COG0138	bifunctional purine biosynthesis protein purh
KAM376_35040	COG0151	Belongs to the GarS family
KAM376_35090	COG3039	Transposase
KAM376_35100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAM376_35110	COG0358	DNA primase activity
KAM376_35120	COG1610	YqeY-like protein
KAM376_35130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KAM376_35140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KAM376_35160	COG4942	peptidase
KAM376_35160	COG1388	LysM domain
KAM376_35170	COG1238	metal cluster binding
KAM376_35180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAM376_35190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KAM376_35200	COG0585	pseudouridine synthase activity
KAM376_35220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KAM376_35230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KAM376_35240	COG0148	phosphopyruvate hydratase activity
KAM376_35250	COG0504	CTP synthase activity
KAM376_35260	COG3956	TIGRFAM MazG family protein
KAM376_35270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAM376_35280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM376_35300	COG4807	Protein conserved in bacteria
KAM376_35310	COG3023	N-Acetylmuramoyl-L-alanine amidase
KAM376_35320	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KAM376_35330	COG1381	Involved in DNA repair and RecF pathway recombination
KAM376_35350	COG0571	ribonuclease III activity
KAM376_35360	COG0681	Belongs to the peptidase S26 family
KAM376_35370	COG0481	GTPase activity
KAM376_35400	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KAM376_35410	COG1595	DNA-templated transcription, initiation
KAM376_35420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KAM376_35440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KAM376_35450	COG0354	folic acid binding
KAM376_35460	COG0583	DNA-binding transcription factor activity
KAM376_35510	COG4232	protein-disulfide reductase activity
KAM376_35530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM376_35550	COG0126	phosphoglycerate kinase activity
KAM376_35560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAM376_35570	COG1940	carbohydrate kinase activity
KAM376_35580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KAM376_35590	COG2816	NAD+ diphosphatase activity
KAM376_35600	COG4991	sh3 domain protein
KAM376_35610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KAM376_35640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KAM376_35650	COG1028	Short-chain dehydrogenase reductase Sdr
KAM376_35670	COG1505	serine-type exopeptidase activity
KAM376_35680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KAM376_35690	COG0765	amino acid transport
KAM376_35700	COG0765	amino acid transport
KAM376_35710	COG1126	abc transporter atp-binding protein
KAM376_35720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM376_35730	COG3174	membrane
KAM376_35740	COG0110	maltose O-acetyltransferase activity
KAM376_35800	COG1942	4-Oxalocrotonate Tautomerase
KAM376_35820	COG0583	DNA-binding transcription factor activity
KAM376_35830	COG0165	Argininosuccinate lyase
KAM376_35840	COG0137	argininosuccinate synthase activity
KAM376_35860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAM376_35870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KAM376_35890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KAM376_35920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KAM376_35990	COG0583	DNA-binding transcription factor activity
KAM376_36000	COG1380	Effector of murein hydrolase LrgA
KAM376_36010	COG1346	cytolysis
KAM376_36020	COG0460	homoserine dehydrogenase
KAM376_36020	COG0527	aspartate kinase activity
KAM376_36030	COG0626	cystathionine gamma-synthase activity
KAM376_36060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM376_36070	COG0814	amino acid
KAM376_36080	COG1218	3'(2'),5'-bisphosphate nucleotidase
KAM376_36090	COG0494	nUDIX hydrolase
KAM376_36100	COG1011	Hydrolase
KAM376_36130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAM376_36160	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KAM376_36180	COG3156	type II secretion system protein K
KAM376_36190	COG4795	General secretion pathway protein
KAM376_36200	COG2165	general secretion pathway protein
KAM376_36220	COG2165	general secretion pathway protein
KAM376_36230	COG1459	type II secretion system
KAM376_36240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM376_36260	COG3031	protein transport across the cell outer membrane
KAM376_36280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KAM376_36290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KAM376_36320	COG0456	acetyltransferase
KAM376_36330	COG3133	Outer membrane lipoprotein
KAM376_36340	COG3025	triphosphatase activity
KAM376_36350	COG1392	Phosphate transport regulator
KAM376_36360	COG0306	phosphate transporter
KAM376_36370	COG0617	tRNA 3'-terminal CCA addition
KAM376_36380	COG3267	Type II secretory pathway component ExeA
KAM376_36380	COG3409	Peptidoglycan-binding domain 1 protein
KAM376_36400	COG1194	a g-specific adenine glycosylase
KAM376_36410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KAM376_36440	COG3240	lipase activity
KAM376_36460	COG3009	Protein conserved in bacteria
KAM376_36470	COG3008	intermembrane lipid transfer
KAM376_36470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAM376_36480	COG2995	paraquat-inducible protein a
KAM376_36500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM376_36510	COG2203	Gaf domain
KAM376_36510	COG5001	Diguanylate cyclase
KAM376_36510	COG4251	negative regulation of phosphorylation
KAM376_36510	COG3706	GGDEF domain
KAM376_36520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAM376_36530	COG2813	Specifically methylates the guanine in position
KAM376_36540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KAM376_36550	COG0297	glycogen (starch) synthase activity
KAM376_36580	COG1757	Na H antiporter
KAM376_36590	COG0583	DNA-binding transcription factor activity
KAM376_36600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KAM376_36610	COG3842	ATPase activity
KAM376_36620	COG1176	ABC-type spermidine putrescine transport system, permease component I
KAM376_36630	COG1177	transmembrane transport
KAM376_36640	COG1012	belongs to the aldehyde dehydrogenase family
KAM376_36650	COG0109	protoheme IX farnesyltransferase activity
KAM376_36710	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KAM376_36730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAM376_36730	COG1565	acr, cog1565
KAM376_36740	COG1444	tRNA N-acetyltransferase activity
KAM376_36780	COG1803	Methylglyoxal synthase
KAM376_36810	COG0252	asparaginase activity
KAM376_36850	COG1263	PTS System
KAM376_36850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM376_36860	COG0366	Alpha amylase catalytic
KAM376_36870	COG0110	maltose O-acetyltransferase activity
KAM376_36880	COG1522	sequence-specific DNA binding
KAM376_36940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KAM376_36950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KAM376_36980	COG0477	Major facilitator Superfamily
KAM376_36990	COG0523	cobalamin synthesis protein
KAM376_37010	COG1280	lysine exporter protein (LysE YggA)
KAM376_37040	COG2200	EAL domain
KAM376_37050	COG1049	propionate catabolic process, 2-methylcitrate cycle
KAM376_37060	COG1752	Esterase of the alpha-beta hydrolase superfamily
KAM376_37070	COG0840	transmembrane signaling receptor activity
KAM376_37080	COG0840	transmembrane signaling receptor activity
KAM376_37100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM376_37110	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAM376_37120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KAM376_37130	COG2186	Transcriptional regulator
KAM376_37180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM376_37190	COG1459	type II secretion system
KAM376_37200	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KAM376_37220	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KAM376_37230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KAM376_37240	COG0494	nUDIX hydrolase
KAM376_37260	COG0653	protein targeting
KAM376_37280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KAM376_37290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KAM376_37300	COG0849	cell division
KAM376_37310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KAM376_37320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAM376_37330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KAM376_37340	COG0772	Belongs to the SEDS family
KAM376_37350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KAM376_37360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KAM376_37370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KAM376_37380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KAM376_37390	COG0768	penicillin binding
KAM376_37400	COG3116	cell division
KAM376_37410	COG0275	rRNA processing
KAM376_37420	COG2001	Belongs to the MraZ family
KAM376_37440	COG0741	lytic transglycosylase activity
KAM376_37440	COG1388	LysM domain
KAM376_37460	COG1360	Flagellar Motor Protein
KAM376_37470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM376_37480	COG1191	sigma factor activity
KAM376_37530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KAM376_37540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM376_37550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM376_37590	COG1256	bacterial-type flagellum assembly
KAM376_37590	COG4786	Flagellar basal body rod
KAM376_37610	COG1706	bacterial-type flagellum-dependent cell motility
KAM376_37620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KAM376_37630	COG4786	Flagellar basal body rod
KAM376_37650	COG1749	Flagellar hook protein flgE
KAM376_37680	COG1815	bacterial-type flagellum-dependent cell motility
KAM376_37690	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
KAM376_37750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KAM376_37770	COG1677	Flagellar hook-basal body complex protein FliE
KAM376_37820	COG1987	bacterial-type flagellum assembly
KAM376_37860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KAM376_37870	COG3107	peptidoglycan biosynthetic process
KAM376_37880	COG0792	nuclease activity
KAM376_37890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAM376_37900	COG2823	Periplasmic or secreted lipoprotein
KAM376_37910	COG2969	positive regulation of protein catabolic process
KAM376_37920	COG0625	glutathione transferase activity
KAM376_37930	COG2857	Cytochrome c1
KAM376_37940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KAM376_37950	COG0723	plastoquinol--plastocyanin reductase activity
KAM376_37960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KAM376_37970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KAM376_37980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KAM376_38000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAM376_38010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAM376_38090	COG3964	amidohydrolase
KAM376_38130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_38140	COG1660	Displays ATPase and GTPase activities
KAM376_38150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM376_38170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KAM376_38180	COG1137	ATPase activity
KAM376_38190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KAM376_38210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KAM376_38220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KAM376_38220	COG0517	IMP dehydrogenase activity
KAM376_38230	COG1127	ABC transporter
KAM376_38240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KAM376_38250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAM376_38260	COG2854	intermembrane phospholipid transfer
KAM376_38280	COG5007	Belongs to the BolA IbaG family
KAM376_38290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KAM376_38300	COG0312	modulator of DNA gyrase
KAM376_38310	COG3028	Belongs to the UPF0307 family
KAM376_38330	COG2926	Belongs to the UPF0265 family
KAM376_38340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KAM376_38350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM376_38350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM376_38360	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KAM376_38370	COG3074	FtsZ-dependent cytokinesis
KAM376_38390	COG1045	serine acetyltransferase
KAM376_38410	COG0745	RESPONSE REGULATOR receiver
KAM376_38420	COG2205	protein histidine kinase activity
KAM376_38430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KAM376_38440	COG0534	Mate efflux family protein
KAM376_38470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAM376_38480	COG2937	Belongs to the GPAT DAPAT family
KAM376_38490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KAM376_38500	COG3161	chorismate lyase activity
KAM376_38510	COG1580	Controls the rotational direction of flagella during chemotaxis
KAM376_38550	COG0604	alcohol dehydrogenase
KAM376_38600	COG3307	-O-antigen
KAM376_38620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAM376_38640	COG0156	8-amino-7-oxononanoate synthase activity
KAM376_38650	COG1063	alcohol dehydrogenase
KAM376_38690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAM376_38700	COG2166	iron-sulfur cluster assembly
KAM376_38710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KAM376_38730	COG1396	sequence-specific DNA binding
KAM376_38740	COG3135	benzoate transporter
KAM376_38800	COG3047	cAMP biosynthetic process
KAM376_38810	COG2801	Transposase and inactivated derivatives
KAM376_38820	COG3415	Transposase
KAM376_38820	COG2801	Transposase and inactivated derivatives
KAM376_38840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KAM376_38850	COG2197	response regulator
KAM376_38920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAM376_38980	COG1396	sequence-specific DNA binding
KAM376_39020	COG1278	Cold shock
KAM376_39080	COG3706	GGDEF domain
KAM376_39090	COG0347	Belongs to the P(II) protein family
KAM376_39100	COG0004	ammonium transporteR
KAM376_39120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAM376_39130	COG1074	ATP-dependent DNA helicase activity
KAM376_39140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KAM376_39150	COG2259	Doxx family
KAM376_39160	COG1741	Belongs to the pirin family
KAM376_39180	COG0583	DNA-binding transcription factor activity
KAM376_39230	COG1175	transmembrane transport
KAM376_39250	COG3842	ATPase activity
KAM376_39310	COG0456	acetyltransferase
KAM376_39320	COG0753	catalase activity
KAM376_39360	COG0494	nUDIX hydrolase
KAM376_39370	COG0628	permease
KAM376_39390	COG0628	permease
KAM376_39440	COG1461	Dihydroxyacetone kinase
KAM376_39450	COG2376	Dihydroxyacetone kinase
KAM376_39460	COG2252	PERMEase
KAM376_39470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KAM376_39480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAM376_39490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAM376_39500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAM376_39510	COG0049	tRNA binding
KAM376_39520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KAM376_39530	COG2168	tRNA wobble position uridine thiolation
KAM376_39550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KAM376_39560	COG0251	oxidation-reduction process
KAM376_39570	COG2964	Protein conserved in bacteria
KAM376_39580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KAM376_39590	COG0085	RNA polymerase activity
KAM376_39600	COG0222	ribosome binding
KAM376_39610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KAM376_39620	COG0081	regulation of translation
KAM376_39630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KAM376_39640	COG0250	Participates in transcription elongation, termination and antitermination
KAM376_39660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAM376_39690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KAM376_39700	COG0569	domain protein
KAM376_39710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM376_39720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAM376_39740	COG3005	denitrification pathway
KAM376_39750	COG0243	molybdopterin cofactor binding
KAM376_39820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KAM376_39840	COG2204	response regulator
KAM376_39860	COG2205	protein histidine kinase activity
KAM376_39890	COG0516	GMP reductase activity
KAM376_39890	COG0517	IMP dehydrogenase activity
KAM376_39910	COG1522	sequence-specific DNA binding
KAM376_39920	COG2502	aspartate--ammonia ligase
KAM376_39940	COG0542	response to heat
KAM376_39960	COG0564	pseudouridine synthase activity
KAM376_39970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM376_39980	COG3681	Belongs to the UPF0597 family
KAM376_39990	COG2964	Protein conserved in bacteria
KAM376_40000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KAM376_40010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KAM376_40020	COG1979	alcohol dehydrogenase
KAM376_40030	COG2207	Transcriptional regulator
KAM376_40040	COG3040	lipid binding
KAM376_40060	COG0840	transmembrane signaling receptor activity
KAM376_40100	COG0540	Belongs to the ATCase OTCase family
KAM376_40110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KAM376_40120	COG1438	arginine binding
KAM376_40130	COG1288	antiporter activity
KAM376_40140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KAM376_40220	COG3250	beta-galactosidase activity
KAM376_40240	COG1609	Transcriptional regulator
KAM376_40250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAM376_40270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KAM376_40280	COG2017	converts alpha-aldose to the beta-anomer
KAM376_40290	COG0667	Aldo Keto reductase
KAM376_40300	COG1968	undecaprenyl-diphosphatase activity
KAM376_40310	COG3806	Anti-sigma factor
KAM376_40320	COG1595	DNA-templated transcription, initiation
KAM376_40360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KAM376_40370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KAM376_40410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM376_40420	COG1131	(ABC) transporter
KAM376_40430	COG0842	Transport permease protein
KAM376_40440	COG0842	Transport permease protein
KAM376_40450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM376_40470	COG2116	formate transmembrane transporter activity
KAM376_40480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM376_40480	COG1648	precorrin-2 dehydrogenase activity
KAM376_40490	COG2239	Acts as a magnesium transporter
KAM376_40500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAM376_40510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KAM376_40530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KAM376_40550	COG0514	ATP-dependent DNA helicase (RecQ)
KAM376_40560	COG2050	protein possibly involved in aromatic compounds catabolism
KAM376_40580	COG2258	MOSC domain
KAM376_40590	COG1177	transmembrane transport
KAM376_40600	COG1176	ABC-type spermidine putrescine transport system, permease component I
KAM376_40610	COG3842	ATPase activity
KAM376_40650	COG0174	glutamine synthetase
KAM376_40690	COG3045	CreA protein
KAM376_40700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAM376_40710	COG0443	Heat shock 70 kDa protein
KAM376_40720	COG3187	Heat shock protein
KAM376_40740	COG0366	Alpha amylase catalytic
KAM376_40780	COG4310	Domain of unknown function (DUF2172)
KAM376_40850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM376_40860	COG0745	RESPONSE REGULATOR receiver
KAM376_40870	COG2205	protein histidine kinase activity
KAM376_40890	COG0281	malic enzyme
KAM376_40900	COG0702	epimerase
KAM376_40910	COG0254	rRNA binding
KAM376_40920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KAM376_40930	COG1309	transcriptional regulator
KAM376_40970	COG0129	dihydroxy-acid dehydratase activity
KAM376_40990	COG3978	acetolactate synthase activity
KAM376_41010	COG0606	chelatase, subunit chli
KAM376_41020	COG0204	Acyl-transferase
KAM376_41030	COG0204	Acyl-transferase
KAM376_41060	COG1335	isochorismatase
KAM376_41080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KAM376_41090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KAM376_41100	COG3639	organic phosphonate transmembrane transporter activity
KAM376_41110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAM376_41120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KAM376_41140	COG3084	Protein conserved in bacteria
KAM376_41150	COG4251	negative regulation of phosphorylation
KAM376_41150	COG3706	GGDEF domain
KAM376_41150	COG2203	Gaf domain
KAM376_41150	COG5001	Diguanylate cyclase
KAM376_41180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KAM376_41190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KAM376_41200	COG1561	YicC-like family, N-terminal region
KAM376_41220	COG1519	Transferase
KAM376_41230	COG0859	PFAM glycosyl transferase family 9
KAM376_41240	COG0463	Glycosyl transferase, family 2
KAM376_41250	COG0859	PFAM glycosyl transferase family 9
KAM376_41260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KAM376_41270	COG2990	Protein conserved in bacteria
KAM376_41290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KAM376_41300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KAM376_41310	COG2003	Belongs to the UPF0758 family
KAM376_41320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KAM376_41330	COG0756	dUTP diphosphatase activity
KAM376_41340	COG1309	transcriptional regulator
KAM376_41350	COG0668	transmembrane transport
KAM376_41370	COG0166	Belongs to the GPI family
KAM376_41380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KAM376_41390	COG0583	DNA-binding transcription factor activity
KAM376_41410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM376_41410	COG1042	CoA-binding domain protein
KAM376_41410	COG0045	succinate-CoA ligase (ADP-forming) activity
KAM376_41420	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KAM376_41430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM376_41440	COG1739	Uncharacterized protein family UPF0029
KAM376_41450	COG0006	proline dipeptidase activity
KAM376_41460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAM376_41470	COG1024	Enoyl-CoA hydratase
KAM376_41470	COG1250	3-hydroxyacyl-CoA dehydrogenase
KAM376_41480	COG0183	Belongs to the thiolase family
KAM376_41510	COG1653	transport
KAM376_41530	COG0425	Belongs to the sulfur carrier protein TusA family
KAM376_41540	COG0251	oxidation-reduction process
KAM376_41560	COG2885	chlorophyll binding
KAM376_41580	COG1335	isochorismatase
KAM376_41590	COG2818	Glycosylase
KAM376_41600	COG0752	glycyl-tRNA synthetase alpha subunit
KAM376_41610	COG0751	glycine-tRNA ligase activity
KAM376_41650	COG3706	GGDEF domain
KAM376_41650	COG2203	Gaf domain
KAM376_41650	COG4251	negative regulation of phosphorylation
KAM376_41650	COG5001	Diguanylate cyclase
KAM376_41680	COG0814	amino acid
KAM376_41690	COG0814	amino acid
KAM376_41700	COG3033	Beta-eliminating lyase
KAM376_41710	COG0348	domain, Protein
KAM376_41730	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM376_41740	COG1773	rubredoxin
KAM376_41740	COG0426	domain, Protein
KAM376_41750	COG3604	Transcriptional regulator
KAM376_41760	COG1609	Transcriptional regulator
KAM376_41840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM376_41870	COG2960	long-chain fatty acid transporting porin activity
KAM376_41890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KAM376_41920	COG3118	belongs to the thioredoxin family
KAM376_41930	COG0513	Belongs to the DEAD box helicase family
KAM376_41940	COG0248	Ppx GppA phosphatase
KAM376_41970	COG0742	ribosomal rna small subunit methyltransferase
KAM376_42010	COG0084	hydrolase, TatD family'
KAM376_42020	COG0805	protein transport
KAM376_42030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM376_42040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM376_42050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KAM376_42060	COG3165	ubiquinone biosynthetic process from chorismate
KAM376_42080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KAM376_42090	COG0402	S-adenosylhomocysteine deaminase activity
KAM376_42110	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KAM376_42120	COG0848	biopolymer transport protein
KAM376_42130	COG0811	peptide transport
KAM376_42140	COG0811	peptide transport
KAM376_42160	COG2771	luxR family
KAM376_42170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KAM376_42180	COG1349	DNA-binding transcription factor activity
KAM376_42190	COG0745	RESPONSE REGULATOR receiver
KAM376_42200	COG2205	protein histidine kinase activity
KAM376_42220	COG4452	Inner membrane protein CreD
KAM376_42230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAM376_42240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KAM376_42250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KAM376_42260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KAM376_42270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KAM376_42280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KAM376_42290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAM376_42310	COG0356	it plays a direct role in the translocation of protons across the membrane
KAM376_42330	COG1475	DNA binding
KAM376_42340	COG1192	Involved in chromosome partitioning
KAM376_42350	COG0357	Ribosomal RNA small subunit methyltransferase G
KAM376_42360	COG0445	tRNA wobble uridine modification
KAM376_42370	COG0716	FMN binding
KAM376_42380	COG4774	siderophore transport
KAM376_42390	COG4615	Cyclic peptide transporter
KAM376_42400	COG1120	ATPase activity
KAM376_42410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KAM376_42430	COG3550	peptidyl-serine autophosphorylation
KAM376_42580	COG4974	Belongs to the 'phage' integrase family
KAM376_42590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KAM376_42600	COG0706	membrane insertase activity
KAM376_42610	COG0594	ribonuclease P activity
KAM376_42620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KAM376_42630	COG1126	abc transporter atp-binding protein
KAM376_42770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KAM376_42850	COG0419	ATPase involved in DNA repair
KAM376_43040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAM376_43240	COG0358	DNA primase activity
KAM376_43270	COG1923	regulation of RNA biosynthetic process
KAM376_43330	COG5301	cellulose 1,4-beta-cellobiosidase activity
KAM376_43590	COG1136	(ABC) transporter
KAM376_43630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAM376_43700	COG4974	Belongs to the 'phage' integrase family
KAM376_43860	COG1192	Involved in chromosome partitioning
KAM376_43980	COG2003	Belongs to the UPF0758 family
KAM376_44060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM376_44140	COG4227	nucleotidyltransferase activity
KAM376_44540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KAM376_44900	COG4644	lycopene metabolic process
KAM376_45030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM376_45100	COG3041	Addiction module toxin RelE StbE family
KAM376_45110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM376_45450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM376_45490	COG1192	Involved in chromosome partitioning
KAM376_45580	COG3039	Transposase