locus-tag	class	description
KAM643c_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KAM643c_00020	COG0592	DNA-directed DNA polymerase activity
KAM643c_00040	COG0187	DNA topoisomerase II activity
KAM643c_00050	COG2207	Transcriptional regulator
KAM643c_00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KAM643c_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
KAM643c_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
KAM643c_00090	COG3977	Valine--pyruvate aminotransferase
KAM643c_00120	COG2814	Major facilitator Superfamily
KAM643c_00130	COG0745	RESPONSE REGULATOR receiver
KAM643c_00140	COG2205	protein histidine kinase activity
KAM643c_00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM643c_00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_00190	COG4191	Histidine kinase
KAM643c_00200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_00210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_00220	COG1309	transcriptional regulator
KAM643c_00240	COG0561	phosphatase activity
KAM643c_00250	COG2267	carboxylic ester hydrolase activity
KAM643c_00260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAM643c_00270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAM643c_00280	COG1758	RNA polymerase activity
KAM643c_00300	COG0859	PFAM glycosyl transferase family 9
KAM643c_00310	COG3642	lipopolysaccharide core region biosynthetic process
KAM643c_00390	COG0589	response to stress
KAM643c_00400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAM643c_00410	COG3706	GGDEF domain
KAM643c_00420	COG1528	Iron-storage protein
KAM643c_00430	COG2081	HI0933 family
KAM643c_00440	COG2223	nitrite transmembrane transporter activity
KAM643c_00450	COG1280	lysine exporter protein (LysE YggA)
KAM643c_00480	COG3188	usher protein
KAM643c_00510	COG2197	response regulator
KAM643c_00530	COG2205	protein histidine kinase activity
KAM643c_00530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_00550	COG3275	phosphorelay sensor kinase activity
KAM643c_00560	COG3279	Response regulator of the LytR AlgR family
KAM643c_00570	COG2223	nitrite transmembrane transporter activity
KAM643c_00580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KAM643c_00590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KAM643c_00620	COG0583	DNA-binding transcription factor activity
KAM643c_00670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KAM643c_00680	COG2166	iron-sulfur cluster assembly
KAM643c_00690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAM643c_00730	COG1063	alcohol dehydrogenase
KAM643c_00760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAM643c_00770	COG0438	transferase activity, transferring glycosyl groups
KAM643c_00840	COG1580	Controls the rotational direction of flagella during chemotaxis
KAM643c_00850	COG3161	chorismate lyase activity
KAM643c_00860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KAM643c_00870	COG2937	Belongs to the GPAT DAPAT family
KAM643c_00880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAM643c_00910	COG0534	Mate efflux family protein
KAM643c_00920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KAM643c_00930	COG2205	protein histidine kinase activity
KAM643c_00940	COG0745	RESPONSE REGULATOR receiver
KAM643c_00960	COG1045	serine acetyltransferase
KAM643c_00980	COG3074	FtsZ-dependent cytokinesis
KAM643c_00990	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KAM643c_01000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM643c_01000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM643c_01010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KAM643c_01020	COG1609	Transcriptional regulator
KAM643c_01030	COG3250	beta-galactosidase activity
KAM643c_01040	COG2731	YhcH YjgK YiaL family protein
KAM643c_01050	COG0531	amino acid
KAM643c_01060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM643c_01070	COG0531	amino acid
KAM643c_01080	COG0385	Bile acid
KAM643c_01090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KAM643c_01140	COG0583	DNA-binding transcription factor activity
KAM643c_01150	COG1079	Belongs to the binding-protein-dependent transport system permease family
KAM643c_01160	COG4603	Belongs to the binding-protein-dependent transport system permease family
KAM643c_01170	COG3845	ABC transporter
KAM643c_01180	COG1744	ABC transporter substrate-binding protein PnrA-like
KAM643c_01220	COG0210	DNA helicase
KAM643c_01240	COG3039	Transposase
KAM643c_01290	COG1943	Transposase
KAM643c_01300	COG0583	DNA-binding transcription factor activity
KAM643c_01400	COG1280	lysine exporter protein (LysE YggA)
KAM643c_01430	COG2962	Rard protein
KAM643c_01450	COG1012	belongs to the aldehyde dehydrogenase family
KAM643c_01460	COG1396	sequence-specific DNA binding
KAM643c_01470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KAM643c_01490	COG0519	Catalyzes the synthesis of GMP from XMP
KAM643c_01490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAM643c_01510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM643c_01550	COG1322	Protein conserved in bacteria
KAM643c_01560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM643c_01570	COG0569	domain protein
KAM643c_01580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM643c_01580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM643c_01590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KAM643c_01600	COG0242	peptide deformylase activity
KAM643c_01620	COG0758	DNA mediated transformation
KAM643c_01630	COG2922	Belongs to the Smg family
KAM643c_01640	COG0551	DNA topoisomerase type I activity
KAM643c_01650	COG0009	L-threonylcarbamoyladenylate synthase
KAM643c_01660	COG0408	coproporphyrinogen oxidase activity
KAM643c_01670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KAM643c_01690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KAM643c_01710	COG3078	GTPase activator activity
KAM643c_01740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KAM643c_01760	COG3852	Histidine kinase
KAM643c_01780	COG0174	glutamine synthetase
KAM643c_01790	COG1217	gtp-binding protein TYPA
KAM643c_01800	COG1295	ribonuclease BN
KAM643c_01810	COG1490	D-aminoacyl-tRNA deacylase activity
KAM643c_01830	COG0456	acetyltransferase
KAM643c_01850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAM643c_01860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAM643c_01870	COG2610	gluconate transmembrane transporter activity
KAM643c_01880	COG3265	gluconokinase activity
KAM643c_01890	COG0129	dihydroxy-acid dehydratase activity
KAM643c_01900	COG0800	Aldolase
KAM643c_01930	COG1609	Transcriptional regulator
KAM643c_01950	COG4942	peptidase
KAM643c_01960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KAM643c_01980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM643c_01990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KAM643c_02000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KAM643c_02010	COG0316	Belongs to the HesB IscA family
KAM643c_02010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KAM643c_02020	COG1040	competence protein
KAM643c_02030	COG0596	Alpha beta hydrolase
KAM643c_02060	COG2183	response to ionizing radiation
KAM643c_02070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAM643c_02090	COG2205	protein histidine kinase activity
KAM643c_02110	COG0051	transcription antitermination factor activity, RNA binding
KAM643c_02120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KAM643c_02130	COG0088	Forms part of the polypeptide exit tunnel
KAM643c_02140	COG0089	rRNA binding
KAM643c_02150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KAM643c_02160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KAM643c_02170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KAM643c_02180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KAM643c_02190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KAM643c_02200	COG0255	Belongs to the universal ribosomal protein uL29 family
KAM643c_02210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KAM643c_02220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KAM643c_02230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KAM643c_02240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KAM643c_02250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KAM643c_02260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KAM643c_02270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KAM643c_02280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KAM643c_02290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KAM643c_02300	COG1841	ribosomal large subunit assembly
KAM643c_02310	COG0200	Binds to the 23S rRNA
KAM643c_02320	COG0201	protein transport
KAM643c_02330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KAM643c_02340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KAM643c_02350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KAM643c_02360	COG0202	RNA polymerase activity
KAM643c_02370	COG0203	ribosomal protein L17
KAM643c_02430	COG2249	NAD(P)H dehydrogenase (quinone) activity
KAM643c_02440	COG0583	DNA-binding transcription factor activity
KAM643c_02450	COG4221	oxidoreductase activity
KAM643c_02480	COG1770	oligopeptidase
KAM643c_02490	COG2358	TRAP transporter, solute receptor (TAXI family
KAM643c_02520	COG3714	YhhN family
KAM643c_02550	COG0583	DNA-binding transcription factor activity
KAM643c_02570	COG1301	dicarboxylic acid transport
KAM643c_02590	COG2095	MarC family integral membrane protein
KAM643c_02610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM643c_02630	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KAM643c_02650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAM643c_02700	COG0742	ribosomal rna small subunit methyltransferase
KAM643c_02710	COG0552	protein localization to endoplasmic reticulum
KAM643c_02720	COG2884	Cell division ATP-binding protein ftsE
KAM643c_02730	COG2177	Part of the ABC transporter FtsEX involved in
KAM643c_02750	COG0288	reversible hydration of carbon dioxide
KAM643c_02760	COG2188	Transcriptional regulator
KAM643c_02770	COG1228	amidohydrolase
KAM643c_02780	COG0010	Belongs to the arginase family
KAM643c_02790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KAM643c_02800	COG2986	histidine ammonia-lyase
KAM643c_02810	COG0387	Pfam Sodium calcium exchanger
KAM643c_02820	COG2200	EAL domain
KAM643c_02930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM643c_02940	COG1459	type II secretion system
KAM643c_02970	COG2165	general secretion pathway protein
KAM643c_02980	COG4969	Belongs to the N-Me-Phe pilin family
KAM643c_03040	COG1077	Cell shape determining protein MreB Mrl
KAM643c_03050	COG1792	Involved in formation and maintenance of cell shape
KAM643c_03060	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KAM643c_03070	COG0424	maF-like protein
KAM643c_03080	COG1530	ribonuclease E activity
KAM643c_03090	COG3164	Protein of unknown function
KAM643c_03100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM643c_03110	COG0312	modulator of DNA gyrase
KAM643c_03150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_03150	COG1263	PTS System
KAM643c_03160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KAM643c_03190	COG0477	Major facilitator Superfamily
KAM643c_03210	COG2321	neutral zinc metallopeptidase
KAM643c_03280	COG0189	ligase activity
KAM643c_03290	COG0642	Histidine kinase
KAM643c_03300	COG0745	RESPONSE REGULATOR receiver
KAM643c_03330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KAM643c_03350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAM643c_03370	COG2022	thiamine diphosphate biosynthetic process
KAM643c_03380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAM643c_03410	COG0110	maltose O-acetyltransferase activity
KAM643c_03440	COG3932	Exopolysaccharide synthesis, ExoD
KAM643c_03490	COG1733	regulation of RNA biosynthetic process
KAM643c_03550	COG1494	fructose-1,6-bisphosphatase
KAM643c_03570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KAM643c_03580	COG5007	Belongs to the BolA IbaG family
KAM643c_03600	COG2854	intermembrane phospholipid transfer
KAM643c_03610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAM643c_03620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KAM643c_03630	COG1127	ABC transporter
KAM643c_03640	COG0517	IMP dehydrogenase activity
KAM643c_03640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KAM643c_03650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KAM643c_03670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KAM643c_03680	COG1137	ATPase activity
KAM643c_03690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KAM643c_03710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_03720	COG1660	Displays ATPase and GTPase activities
KAM643c_03730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_03770	COG3964	amidohydrolase
KAM643c_03830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAM643c_03840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAM643c_03860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KAM643c_03870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KAM643c_03880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KAM643c_03890	COG0723	plastoquinol--plastocyanin reductase activity
KAM643c_03900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KAM643c_03910	COG2857	Cytochrome c1
KAM643c_03920	COG0625	glutathione transferase activity
KAM643c_03930	COG2969	positive regulation of protein catabolic process
KAM643c_03940	COG2823	Periplasmic or secreted lipoprotein
KAM643c_03950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAM643c_03960	COG0792	nuclease activity
KAM643c_03970	COG3107	peptidoglycan biosynthetic process
KAM643c_03980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KAM643c_04000	COG2001	Belongs to the MraZ family
KAM643c_04010	COG0275	rRNA processing
KAM643c_04020	COG3116	cell division
KAM643c_04030	COG0768	penicillin binding
KAM643c_04040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KAM643c_04050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KAM643c_04060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KAM643c_04070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KAM643c_04080	COG0772	Belongs to the SEDS family
KAM643c_04090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KAM643c_04100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAM643c_04110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KAM643c_04120	COG0849	cell division
KAM643c_04130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KAM643c_04140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KAM643c_04160	COG0653	protein targeting
KAM643c_04180	COG0494	nUDIX hydrolase
KAM643c_04190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KAM643c_04200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KAM643c_04220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KAM643c_04230	COG1459	type II secretion system
KAM643c_04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM643c_04290	COG2186	Transcriptional regulator
KAM643c_04300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KAM643c_04310	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAM643c_04320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM643c_04340	COG0840	transmembrane signaling receptor activity
KAM643c_04350	COG0840	transmembrane signaling receptor activity
KAM643c_04360	COG1752	Esterase of the alpha-beta hydrolase superfamily
KAM643c_04370	COG1049	propionate catabolic process, 2-methylcitrate cycle
KAM643c_04380	COG2200	EAL domain
KAM643c_04400	COG1280	lysine exporter protein (LysE YggA)
KAM643c_04420	COG0523	cobalamin synthesis protein
KAM643c_04430	COG0477	Major facilitator Superfamily
KAM643c_04460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KAM643c_04470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KAM643c_04520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KAM643c_04540	COG1546	Belongs to the CinA family
KAM643c_04550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAM643c_04560	COG2137	regulation of response to DNA damage stimulus
KAM643c_04570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KAM643c_04580	COG0527	aspartate kinase activity
KAM643c_04590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KAM643c_04600	COG1686	Belongs to the peptidase S11 family
KAM643c_04610	COG0586	Pfam SNARE associated Golgi protein
KAM643c_04620	COG1253	flavin adenine dinucleotide binding
KAM643c_04630	COG0525	valine-tRNA ligase activity
KAM643c_04650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAM643c_04660	COG0795	lipopolysaccharide-transporting ATPase activity
KAM643c_04670	COG0795	lipopolysaccharide-transporting ATPase activity
KAM643c_04760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KAM643c_04950	COG4695	Portal protein
KAM643c_05030	COG2801	Transposase and inactivated derivatives
KAM643c_05240	COG4974	Belongs to the 'phage' integrase family
KAM643c_05270	COG0004	ammonium transporteR
KAM643c_05280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM643c_05310	COG2165	general secretion pathway protein
KAM643c_05320	COG0084	hydrolase, TatD family'
KAM643c_05330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM643c_05350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KAM643c_05360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KAM643c_05370	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KAM643c_05380	COG0813	purine-nucleoside phosphorylase activity
KAM643c_05390	COG3447	MASE1 domain protein
KAM643c_05390	COG5001	Diguanylate cyclase
KAM643c_05390	COG5002	protein histidine kinase activity
KAM643c_05410	COG0560	Phosphoserine phosphatase
KAM643c_05440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KAM643c_05460	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KAM643c_05470	COG0776	regulation of translation
KAM643c_05500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM643c_05510	COG0735	belongs to the Fur family
KAM643c_05550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KAM643c_05560	COG0513	Belongs to the DEAD box helicase family
KAM643c_05570	COG3022	response to hydroperoxide
KAM643c_05600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KAM643c_05610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KAM643c_05620	COG0762	integral membrane protein
KAM643c_05630	COG1872	DUF167
KAM643c_05680	COG3112	Uncharacterised protein family (UPF0231)
KAM643c_05690	COG3835	regulator
KAM643c_05700	COG2610	gluconate transmembrane transporter activity
KAM643c_05710	COG1929	Belongs to the glycerate kinase type-1 family
KAM643c_05740	COG0583	DNA-binding transcription factor activity
KAM643c_05750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM643c_05780	COG0347	Belongs to the P(II) protein family
KAM643c_05810	COG3842	ATPase activity
KAM643c_05820	COG2837	iron assimilation
KAM643c_05830	COG1438	arginine binding
KAM643c_05840	COG1126	abc transporter atp-binding protein
KAM643c_05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_05860	COG4215	(ABC) transporter
KAM643c_05870	COG4160	amino acid transport
KAM643c_05880	COG0039	L-malate dehydrogenase activity
KAM643c_05900	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KAM643c_05910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KAM643c_05910	COG1017	nitric oxide dioxygenase activity
KAM643c_05930	COG4536	flavin adenine dinucleotide binding
KAM643c_05940	COG4137	Cytochrome C assembly protein
KAM643c_05950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KAM643c_05960	COG0228	four-way junction DNA binding
KAM643c_05970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KAM643c_05980	COG0336	Belongs to the RNA methyltransferase TrmD family
KAM643c_05990	COG0335	large ribosomal subunit rRNA binding
KAM643c_06010	COG3066	DNA modification
KAM643c_06020	COG1051	belongs to the nudix hydrolase family
KAM643c_06040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KAM643c_06050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KAM643c_06060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAM643c_06080	COG0583	DNA-binding transcription factor activity
KAM643c_06090	COG0640	Transcriptional regulator
KAM643c_06100	COG0268	Binds directly to 16S ribosomal RNA
KAM643c_06110	COG0728	peptidoglycan biosynthetic process
KAM643c_06120	COG0196	riboflavin kinase activity
KAM643c_06130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KAM643c_06140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KAM643c_06150	COG1047	Peptidyl-prolyl cis-trans
KAM643c_06160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KAM643c_06220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KAM643c_06220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM643c_06250	COG1854	S-ribosylhomocysteine lyase activity
KAM643c_06260	COG3706	GGDEF domain
KAM643c_06270	COG0557	exoribonuclease II activity
KAM643c_06330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAM643c_06350	COG2153	protein acetylation
KAM643c_06370	COG1914	H( )-stimulated, divalent metal cation uptake system
KAM643c_06380	COG0360	Binds together with S18 to 16S ribosomal RNA
KAM643c_06390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KAM643c_06400	COG0359	binds to the 23S rRNA
KAM643c_06480	COG1238	metal cluster binding
KAM643c_06490	COG0612	Peptidase, M16
KAM643c_06500	COG2918	glutathione biosynthetic process
KAM643c_06510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAM643c_06520	COG1027	Aspartate ammonia-lyase
KAM643c_06530	COG3030	protein affecting phage T7 exclusion by the F plasmid
KAM643c_06540	COG0534	Mate efflux family protein
KAM643c_06550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAM643c_06560	COG0459	protein refolding
KAM643c_06600	COG0564	pseudouridine synthase activity
KAM643c_06610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KAM643c_06620	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KAM643c_06630	COG1484	DNA-dependent DNA replication
KAM643c_06640	COG4584	PFAM Integrase catalytic
KAM643c_06650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KAM643c_06670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KAM643c_06680	COG4208	sulfate ABC transporter
KAM643c_06690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KAM643c_06700	COG0583	DNA-binding transcription factor activity
KAM643c_06710	COG3397	chitin binding
KAM643c_06720	COG0840	transmembrane signaling receptor activity
KAM643c_06770	COG1328	CTP reductase activity
KAM643c_06780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KAM643c_06810	COG1448	Aminotransferase
KAM643c_06820	COG2194	sulfuric ester hydrolase activity
KAM643c_06870	COG1215	transferase activity, transferring glycosyl groups
KAM643c_06880	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KAM643c_06890	COG3118	belongs to the thioredoxin family
KAM643c_06890	COG0457	Tetratricopeptide repeat
KAM643c_06960	COG0513	Belongs to the DEAD box helicase family
KAM643c_06970	COG0840	transmembrane signaling receptor activity
KAM643c_06990	COG4166	transmembrane transport
KAM643c_07020	COG1024	Enoyl-CoA hydratase
KAM643c_07050	COG4221	oxidoreductase activity
KAM643c_07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM643c_07070	COG0442	prolyl-tRNA aminoacylation
KAM643c_07080	COG0840	transmembrane signaling receptor activity
KAM643c_07090	COG0632	four-way junction helicase activity
KAM643c_07100	COG2255	four-way junction helicase activity
KAM643c_07110	COG1271	oxidase subunit
KAM643c_07120	COG1294	oxidase, subunit
KAM643c_07130	COG3790	cyd operon protein YbgE
KAM643c_07140	COG0824	Thioesterase
KAM643c_07150	COG0811	peptide transport
KAM643c_07180	COG0823	Involved in the tonB-independent uptake of proteins
KAM643c_07190	COG2885	chlorophyll binding
KAM643c_07200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KAM643c_07210	COG0840	transmembrane signaling receptor activity
KAM643c_07220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KAM643c_07240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAM643c_07250	COG1640	4-alpha-glucanotransferase
KAM643c_07260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KAM643c_07320	COG2130	NADP-dependent
KAM643c_07330	COG1846	Transcriptional regulator
KAM643c_07390	COG0561	phosphatase activity
KAM643c_07420	COG0733	neurotransmitter:sodium symporter activity
KAM643c_07430	COG0733	neurotransmitter:sodium symporter activity
KAM643c_07460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM643c_07500	COG1794	racemase activity, acting on amino acids and derivatives
KAM643c_07520	COG1022	Amp-dependent synthetase and ligase
KAM643c_07540	COG0456	acetyltransferase
KAM643c_07570	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KAM643c_07580	COG5001	Diguanylate cyclase
KAM643c_07580	COG5002	protein histidine kinase activity
KAM643c_07600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KAM643c_07620	COG0456	acetyltransferase
KAM643c_07640	COG0456	acetyltransferase
KAM643c_07650	COG1902	pentaerythritol trinitrate reductase activity
KAM643c_07670	COG2852	Protein conserved in bacteria
KAM643c_07690	COG2957	Belongs to the agmatine deiminase family
KAM643c_07700	COG0154	amidase activity
KAM643c_07790	COG2207	Transcriptional regulator
KAM643c_07790	COG1917	Cupin 2, conserved barrel domain protein
KAM643c_07810	COG0513	Belongs to the DEAD box helicase family
KAM643c_07820	COG2199	diguanylate cyclase activity
KAM643c_07820	COG2203	Gaf domain
KAM643c_07910	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
KAM643c_07940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM643c_07960	COG4584	PFAM Integrase catalytic
KAM643c_07970	COG1484	DNA-dependent DNA replication
KAM643c_07980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KAM643c_08000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KAM643c_08010	COG1178	ABC-type Fe3 transport system permease component
KAM643c_08020	COG4143	(ABC) transporter
KAM643c_08050	COG0066	3-isopropylmalate dehydratase activity
KAM643c_08060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KAM643c_08070	COG0473	3-isopropylmalate dehydrogenase activity
KAM643c_08080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KAM643c_08100	COG0671	phosphoesterase, PA-phosphatase related
KAM643c_08130	COG0028	Belongs to the TPP enzyme family
KAM643c_08140	COG0440	acetolactate synthase activity
KAM643c_08150	COG0857	belongs to the CobB CobQ family
KAM643c_08150	COG0280	phosphate acetyltransferase
KAM643c_08160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KAM643c_08180	COG3013	Belongs to the UPF0304 family
KAM643c_08190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KAM643c_08200	COG2716	regulation of RNA biosynthetic process
KAM643c_08210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAM643c_08220	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KAM643c_08230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KAM643c_08270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KAM643c_08310	COG2198	Histidine kinase
KAM643c_08310	COG5002	protein histidine kinase activity
KAM643c_08310	COG0784	Response regulator, receiver
KAM643c_08340	COG0784	Response regulator, receiver
KAM643c_08340	COG2205	protein histidine kinase activity
KAM643c_08380	COG1464	Belongs to the NlpA lipoprotein family
KAM643c_08390	COG2011	ABC-type metal ion transport system permease component
KAM643c_08400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAM643c_08440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KAM643c_08440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KAM643c_08450	COG0802	atpase or kinase
KAM643c_08470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KAM643c_08480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KAM643c_08490	COG1923	regulation of RNA biosynthetic process
KAM643c_08500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KAM643c_08510	COG0330	HflC and HflK could
KAM643c_08520	COG0330	HflC and HflK could
KAM643c_08530	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KAM643c_08540	COG0142	geranyltranstransferase activity
KAM643c_08550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KAM643c_08560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KAM643c_08570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KAM643c_08580	COG3314	Sporulation integral membrane protein YlbJ
KAM643c_08590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM643c_08600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KAM643c_08620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KAM643c_08630	COG2967	ApaG domain
KAM643c_08640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KAM643c_08650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KAM643c_08670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KAM643c_08680	COG3178	'Phosphotransferase
KAM643c_08690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KAM643c_08700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAM643c_08710	COG2252	PERMEase
KAM643c_08730	COG0488	(ABC) transporter
KAM643c_08740	COG0741	lytic transglycosylase activity
KAM643c_08750	COG0463	Glycosyl transferase, family 2
KAM643c_08770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KAM643c_08820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM643c_08840	COG3721	Heme iron utilization protein
KAM643c_08850	COG0748	coenzyme F420 binding
KAM643c_08900	COG2814	Major facilitator Superfamily
KAM643c_08910	COG2202	Pas domain
KAM643c_08910	COG2205	protein histidine kinase activity
KAM643c_08930	COG2226	methyltransferase
KAM643c_08950	COG1765	OsmC-like protein
KAM643c_08980	COG3954	Phosphoribulokinase
KAM643c_08990	COG3089	Belongs to the UPF0270 family
KAM643c_09000	COG5001	Diguanylate cyclase
KAM643c_09000	COG2203	Gaf domain
KAM643c_09000	COG3706	GGDEF domain
KAM643c_09000	COG4251	negative regulation of phosphorylation
KAM643c_09010	COG0429	hydrolase of the alpha beta-hydrolase fold
KAM643c_09020	COG0784	Response regulator, receiver
KAM643c_09020	COG0835	chemotaxis
KAM643c_09040	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KAM643c_09050	COG1047	Peptidyl-prolyl cis-trans
KAM643c_09060	COG2900	Belongs to the SlyX family
KAM643c_09080	COG0545	Peptidyl-prolyl cis-trans isomerase
KAM643c_09090	COG2204	response regulator
KAM643c_09130	COG0737	Belongs to the 5'-nucleotidase family
KAM643c_09140	COG5433	transposase activity
KAM643c_09170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAM643c_09180	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KAM643c_09180	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KAM643c_09180	COG0506	proline dehydrogenase activity
KAM643c_09200	COG0114	fumarate hydratase activity
KAM643c_09220	COG1566	PFAM secretion protein HlyD family protein
KAM643c_09310	COG2200	EAL domain
KAM643c_09310	COG2203	Gaf domain
KAM643c_09310	COG2199	diguanylate cyclase activity
KAM643c_09330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAM643c_09350	COG1280	lysine exporter protein (LysE YggA)
KAM643c_09360	COG0826	peptidase U32
KAM643c_09380	COG3813	Protein conserved in bacteria
KAM643c_09420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KAM643c_09470	COG0300	oxidoreductase activity
KAM643c_09510	COG2610	gluconate transmembrane transporter activity
KAM643c_09520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAM643c_09530	COG3622	Belongs to the hyi family
KAM643c_09540	COG0235	Class ii aldolase
KAM643c_09550	COG3395	kinase activity
KAM643c_09560	COG2084	Dehydrogenase
KAM643c_09570	COG1349	DNA-binding transcription factor activity
KAM643c_09590	COG2133	pyrroloquinoline quinone binding
KAM643c_09670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAM643c_09690	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM643c_09750	COG3385	transposase activity
KAM643c_09770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM643c_09780	COG1484	DNA-dependent DNA replication
KAM643c_09790	COG4584	PFAM Integrase catalytic
KAM643c_09810	COG3039	Transposase
KAM643c_09860	COG1605	Chorismate mutase
KAM643c_09860	COG0077	Prephenate dehydratase
KAM643c_09920	COG3272	Protein of unknown function (DUF1722)
KAM643c_09930	COG0789	Transcriptional regulator
KAM643c_09940	COG0415	Belongs to the DNA photolyase family
KAM643c_09960	COG4221	oxidoreductase activity
KAM643c_09990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KAM643c_10040	COG0783	Belongs to the Dps family
KAM643c_10050	COG1151	hydroxylamine reductase activity
KAM643c_10070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAM643c_10100	COG1447	Phosphotransferase system cellobiose-specific component IIA
KAM643c_10110	COG2723	6-phospho-beta-galactosidase activity
KAM643c_10130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KAM643c_10140	COG5297	Belongs to the glycosyl hydrolase family 6
KAM643c_10140	COG2273	Hydrolase Family 16
KAM643c_10150	COG1472	Belongs to the glycosyl hydrolase 3 family
KAM643c_10160	COG0840	transmembrane signaling receptor activity
KAM643c_10170	COG2182	Extracellular solute-binding protein
KAM643c_10180	COG1609	Transcriptional regulator
KAM643c_10220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_10240	COG0745	RESPONSE REGULATOR receiver
KAM643c_10250	COG2205	protein histidine kinase activity
KAM643c_10260	COG0659	secondary active sulfate transmembrane transporter activity
KAM643c_10290	COG1666	GTP binding
KAM643c_10310	COG2211	Major facilitator Superfamily
KAM643c_10330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAM643c_10350	COG2813	Specifically methylates the guanine in position
KAM643c_10360	COG0271	Belongs to the BolA IbaG family
KAM643c_10370	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM643c_10380	COG1805	sodium ion transport
KAM643c_10390	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM643c_10400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM643c_10410	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM643c_10420	COG2871	sodium ion transport
KAM643c_10430	COG1477	protein flavinylation
KAM643c_10460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM643c_10470	COG0840	transmembrane signaling receptor activity
KAM643c_10480	COG0583	DNA-binding transcription factor activity
KAM643c_10510	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KAM643c_10530	COG0473	3-isopropylmalate dehydrogenase activity
KAM643c_10540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAM643c_10560	COG1611	Belongs to the LOG family
KAM643c_10590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAM643c_10590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAM643c_10610	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KAM643c_10660	COG3098	single-species biofilm formation
KAM643c_10670	COG0564	pseudouridine synthase activity
KAM643c_10690	COG4580	involved in the transport of maltose and maltodextrins
KAM643c_10710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_10710	COG1263	PTS System
KAM643c_10730	COG2171	N-acyltransferase activity
KAM643c_10740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KAM643c_10750	COG0024	Methionine aminopeptidase
KAM643c_10760	COG0052	Belongs to the universal ribosomal protein uS2 family
KAM643c_10770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KAM643c_10780	COG0528	UMP kinase activity
KAM643c_10790	COG0233	cytoplasmic translational termination
KAM643c_10800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KAM643c_10810	COG0575	Belongs to the CDS family
KAM643c_10820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KAM643c_10830	COG0750	zinc metalloprotease
KAM643c_10860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM643c_10870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAM643c_10880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM643c_10890	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM643c_10900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KAM643c_10910	COG0587	DNA-directed DNA polymerase activity
KAM643c_10920	COG0825	malonyl-CoA metabolic process
KAM643c_10950	COG0814	amino acid
KAM643c_10960	COG0531	amino acid
KAM643c_10980	COG0488	(ABC) transporter
KAM643c_11010	COG0037	tRNA processing
KAM643c_11020	COG3706	GGDEF domain
KAM643c_11110	COG0366	Alpha amylase catalytic
KAM643c_11140	COG0463	Glycosyl transferase, family 2
KAM643c_11170	COG2989	Protein conserved in bacteria
KAM643c_11180	COG3108	Peptidase M15
KAM643c_11200	COG2860	membrane
KAM643c_11220	COG1196	nuclear chromosome segregation
KAM643c_11230	COG3115	cell septum assembly
KAM643c_11240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAM643c_11260	COG1328	CTP reductase activity
KAM643c_11270	COG0602	queuosine metabolic process
KAM643c_11330	COG1566	PFAM secretion protein HlyD family protein
KAM643c_11350	COG3290	protein histidine kinase activity
KAM643c_11380	COG0667	Aldo Keto reductase
KAM643c_11400	COG0697	spore germination
KAM643c_11430	COG3284	Transcriptional regulator
KAM643c_11440	COG3706	GGDEF domain
KAM643c_11450	COG0346	lactoylglutathione lyase activity
KAM643c_11460	COG0745	RESPONSE REGULATOR receiver
KAM643c_11470	COG5002	protein histidine kinase activity
KAM643c_11490	COG4783	chaperone-mediated protein folding
KAM643c_11510	COG1940	carbohydrate kinase activity
KAM643c_11520	COG3142	Participates in the control of copper homeostasis
KAM643c_11550	COG0545	Peptidyl-prolyl cis-trans isomerase
KAM643c_11590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_11600	COG4597	amino acid ABC transporter
KAM643c_11610	COG0765	amino acid transport
KAM643c_11620	COG1126	abc transporter atp-binding protein
KAM643c_11640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KAM643c_11650	COG0678	peroxiredoxin activity
KAM643c_11670	COG0019	diaminopimelate decarboxylase activity
KAM643c_11680	COG1115	amino acid carrier protein
KAM643c_11690	COG0095	Lipoate-protein ligase
KAM643c_11700	COG2233	PERMEase
KAM643c_11750	COG2207	Transcriptional regulator
KAM643c_11760	COG0281	malic enzyme
KAM643c_11830	COG0733	neurotransmitter:sodium symporter activity
KAM643c_11840	COG1752	Esterase of the alpha-beta hydrolase superfamily
KAM643c_11850	COG3706	GGDEF domain
KAM643c_11870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_11880	COG1032	radical SAM domain protein
KAM643c_11930	COG3385	transposase activity
KAM643c_11950	COG0673	inositol 2-dehydrogenase activity
KAM643c_11960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KAM643c_11970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KAM643c_11980	COG0739	heme binding
KAM643c_11980	COG0741	lytic transglycosylase activity
KAM643c_11980	COG1196	nuclear chromosome segregation
KAM643c_12030	COG0788	formyltetrahydrofolate deformylase activity
KAM643c_12040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAM643c_12060	COG3118	belongs to the thioredoxin family
KAM643c_12080	COG0791	NLP P60 protein
KAM643c_12090	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KAM643c_12120	COG1388	LysM domain
KAM643c_12120	COG1376	ErfK ybiS ycfS ynhG family protein
KAM643c_12130	COG2205	protein histidine kinase activity
KAM643c_12130	COG0784	Response regulator, receiver
KAM643c_12160	COG2205	protein histidine kinase activity
KAM643c_12160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_12170	COG3384	dioxygenase
KAM643c_12190	COG1283	sodium-dependent phosphate transmembrane transporter activity
KAM643c_12210	COG0531	amino acid
KAM643c_12220	COG0531	amino acid
KAM643c_12250	COG1012	belongs to the aldehyde dehydrogenase family
KAM643c_12260	COG1917	Cupin 2, conserved barrel domain protein
KAM643c_12260	COG1396	sequence-specific DNA binding
KAM643c_12270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM643c_12340	COG4651	solute:proton antiporter activity
KAM643c_12340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAM643c_12350	COG0405	Gamma-glutamyltransferase
KAM643c_12370	COG2974	May be involved in recombination
KAM643c_12380	COG1247	-acetyltransferase
KAM643c_12400	COG0420	3'-5' exonuclease activity
KAM643c_12420	COG3385	transposase activity
KAM643c_12440	COG3038	cytochrome b561
KAM643c_12450	COG2190	(PTS) system
KAM643c_12470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_12480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KAM643c_12490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAM643c_12520	COG1720	tRNA m6t6A37 methyltransferase activity
KAM643c_12570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KAM643c_12580	COG4988	ABC transporter
KAM643c_12590	COG0745	RESPONSE REGULATOR receiver
KAM643c_12610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAM643c_12640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KAM643c_12650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KAM643c_12670	COG0083	homoserine kinase activity
KAM643c_12680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KAM643c_12750	COG5433	transposase activity
KAM643c_12770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KAM643c_12790	COG3220	belongs to the UPF0276 family
KAM643c_12850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM643c_12870	COG1289	transmembrane transporter activity
KAM643c_12880	COG1763	Mo-molybdopterin cofactor biosynthetic process
KAM643c_12890	COG0746	molybdenum cofactor guanylyltransferase activity
KAM643c_12900	COG0281	malic enzyme
KAM643c_12980	COG1196	nuclear chromosome segregation
KAM643c_12980	COG3264	Mechanosensitive ion channel
KAM643c_13000	COG2850	peptidyl-arginine hydroxylation
KAM643c_13010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KAM643c_13020	COG2915	High frequency lysogenization protein hflD homolog
KAM643c_13030	COG0482	sulfurtransferase activity
KAM643c_13050	COG1187	pseudouridine synthase activity
KAM643c_13060	COG0456	acetyltransferase
KAM643c_13140	COG0538	isocitrate dehydrogenase activity
KAM643c_13160	COG3048	D-serine ammonia-lyase activity
KAM643c_13170	COG0583	DNA-binding transcription factor activity
KAM643c_13180	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM643c_13190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM643c_13200	COG2375	cellular response to nickel ion
KAM643c_13210	COG1538	Outer membrane efflux protein
KAM643c_13220	COG1136	(ABC) transporter
KAM643c_13220	COG0577	efflux transmembrane transporter activity
KAM643c_13230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_13250	COG0497	DNA recombination
KAM643c_13260	COG3706	GGDEF domain
KAM643c_13270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KAM643c_13290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KAM643c_13300	COG0443	Heat shock 70 kDa protein
KAM643c_13310	COG0484	heat shock protein binding
KAM643c_13380	COG1285	pathogenesis
KAM643c_13400	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM643c_13420	COG0640	Transcriptional regulator
KAM643c_13480	COG0095	Lipoate-protein ligase
KAM643c_13510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_13520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_13550	COG0708	Exodeoxyribonuclease III
KAM643c_13570	COG0745	RESPONSE REGULATOR receiver
KAM643c_13600	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KAM643c_13630	COG1846	Transcriptional regulator
KAM643c_13650	COG0675	Transposase, IS605 OrfB family
KAM643c_13680	COG0583	DNA-binding transcription factor activity
KAM643c_13690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KAM643c_13720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAM643c_13730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KAM643c_13740	COG1845	cytochrome c oxidase, subunit III
KAM643c_13750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KAM643c_13760	COG0109	protoheme IX farnesyltransferase activity
KAM643c_13770	COG2814	Major facilitator Superfamily
KAM643c_13780	COG5507	3-demethylubiquinone-9 3-methyltransferase
KAM643c_13840	COG3550	peptidyl-serine autophosphorylation
KAM643c_13850	COG1396	sequence-specific DNA binding
KAM643c_13860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM643c_13890	COG0159	tryptophan synthase activity
KAM643c_13900	COG0133	tryptophan synthase activity
KAM643c_13910	COG0134	indole-3-glycerol-phosphate synthase activity
KAM643c_13910	COG0135	phosphoribosylanthranilate isomerase activity
KAM643c_13920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KAM643c_13930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KAM643c_13930	COG0512	Glutamine amidotransferase of anthranilate synthase
KAM643c_13940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KAM643c_13950	COG0613	PHP domain protein
KAM643c_13960	COG0009	L-threonylcarbamoyladenylate synthase
KAM643c_13980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KAM643c_14000	COG1946	Acyl-CoA thioesterase
KAM643c_14030	COG1309	transcriptional regulator
KAM643c_14040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_14050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_14160	COG1484	DNA-dependent DNA replication
KAM643c_14170	COG4584	PFAM Integrase catalytic
KAM643c_14200	COG2003	Belongs to the UPF0758 family
KAM643c_14230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KAM643c_14260	COG0583	DNA-binding transcription factor activity
KAM643c_14290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KAM643c_14310	COG1960	acyl-CoA dehydrogenase activity
KAM643c_14320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAM643c_14340	COG0469	pyruvate kinase activity
KAM643c_14350	COG1737	Transcriptional regulator
KAM643c_14400	COG1091	dTDP-4-dehydrorhamnose reductase activity
KAM643c_14580	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
KAM643c_14630	COG3132	Protein of unknown function, DUF480
KAM643c_14680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KAM643c_14710	COG1278	Cold shock
KAM643c_14760	COG0675	Transposase, IS605 OrfB family
KAM643c_14810	COG0697	spore germination
KAM643c_14830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAM643c_14860	COG4166	transmembrane transport
KAM643c_14870	COG0622	Phosphoesterase
KAM643c_14900	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
KAM643c_14910	COG0784	Response regulator, receiver
KAM643c_14910	COG0835	chemotaxis
KAM643c_14920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KAM643c_14930	COG1815	bacterial-type flagellum-dependent cell motility
KAM643c_14990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KAM643c_15000	COG1706	bacterial-type flagellum-dependent cell motility
KAM643c_15010	COG3951	Flagellar rod assembly protein muramidase FlgJ
KAM643c_15010	COG1705	Flagellar rod assembly protein muramidase FlgJ
KAM643c_15040	COG2239	Acts as a magnesium transporter
KAM643c_15060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KAM643c_15070	COG2716	regulation of RNA biosynthetic process
KAM643c_15090	COG3335	DDE superfamily endonuclease
KAM643c_15140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KAM643c_15150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KAM643c_15160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KAM643c_15180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KAM643c_15220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KAM643c_15240	COG0590	tRNA wobble adenosine to inosine editing
KAM643c_15250	COG0573	inorganic phosphate transmembrane transporter activity
KAM643c_15260	COG0581	inorganic phosphate transmembrane transporter activity
KAM643c_15270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAM643c_15280	COG0704	Plays a role in the regulation of phosphate uptake
KAM643c_15290	COG1253	flavin adenine dinucleotide binding
KAM643c_15320	COG0531	amino acid
KAM643c_15340	COG1126	abc transporter atp-binding protein
KAM643c_15350	COG0765	amino acid transport
KAM643c_15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_15370	COG3706	GGDEF domain
KAM643c_15380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAM643c_15420	COG1785	Belongs to the alkaline phosphatase family
KAM643c_15430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KAM643c_15440	COG0477	Major facilitator Superfamily
KAM643c_15450	COG0123	including yeast histone deacetylase and acetoin utilization protein
KAM643c_15470	COG1199	ATP-dependent helicase activity
KAM643c_15480	COG5433	transposase activity
KAM643c_15530	COG1448	Aminotransferase
KAM643c_15540	COG0433	COG0433 Predicted ATPase
KAM643c_15570	COG2333	competence protein COMEC
KAM643c_15570	COG0658	competence protein
KAM643c_15580	COG1132	(ABC) transporter
KAM643c_15590	COG1663	tetraacyldisaccharide 4'-kinase activity
KAM643c_15600	COG2835	tetraacyldisaccharide 4'-kinase activity
KAM643c_15610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KAM643c_15620	COG2197	response regulator
KAM643c_15630	COG0322	excinuclease ABC activity
KAM643c_15660	COG0604	alcohol dehydrogenase
KAM643c_15670	COG1309	transcriptional regulator
KAM643c_15680	COG2261	transglycosylase associated protein
KAM643c_15690	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAM643c_15710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAM643c_15720	COG0215	cysteine-tRNA ligase activity
KAM643c_15770	COG3039	Transposase
KAM643c_15840	COG3385	transposase activity
KAM643c_15860	COG2203	Gaf domain
KAM643c_15860	COG2199	diguanylate cyclase activity
KAM643c_15930	COG2119	membrane
KAM643c_15940	COG0023	Translation Initiation Factor
KAM643c_15960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KAM643c_16010	COG4139	cobalamin transport
KAM643c_16020	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
KAM643c_16030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM643c_16040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KAM643c_16050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAM643c_16060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAM643c_16070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KAM643c_16090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KAM643c_16100	COG0505	Belongs to the CarA family
KAM643c_16110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KAM643c_16120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KAM643c_16130	COG3706	GGDEF domain
KAM643c_16190	COG0513	Belongs to the DEAD box helicase family
KAM643c_16210	COG4104	PAAR repeat-containing protein
KAM643c_16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_16250	COG0765	amino acid transport
KAM643c_16260	COG1126	abc transporter atp-binding protein
KAM643c_16270	COG0493	'glutamate synthase
KAM643c_16280	COG0070	glutamate synthase
KAM643c_16280	COG0069	glutamate synthase activity
KAM643c_16280	COG0067	glutamate synthase
KAM643c_16290	COG1242	4 iron, 4 sulfur cluster binding
KAM643c_16340	COG5433	transposase activity
KAM643c_16450	COG1113	amino acid transport
KAM643c_16470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KAM643c_16480	COG0574	Belongs to the PEP-utilizing enzyme family
KAM643c_16480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAM643c_16490	COG1119	ATPase activity
KAM643c_16530	COG1464	Belongs to the NlpA lipoprotein family
KAM643c_16550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAM643c_16560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAM643c_16580	COG0101	tRNA pseudouridine synthase activity
KAM643c_16590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KAM643c_16600	COG0285	dihydrofolate synthase activity
KAM643c_16610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KAM643c_16620	COG2920	part of a sulfur-relay system
KAM643c_16630	COG1289	transmembrane transporter activity
KAM643c_16640	COG0670	Belongs to the BI1 family
KAM643c_16680	COG5433	transposase activity
KAM643c_16730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KAM643c_16740	COG0840	transmembrane signaling receptor activity
KAM643c_16760	COG5001	Diguanylate cyclase
KAM643c_16770	COG0564	pseudouridine synthase activity
KAM643c_16800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KAM643c_16820	COG0625	glutathione transferase activity
KAM643c_16850	COG0367	asparagine synthase
KAM643c_16870	COG0647	UMP catabolic process
KAM643c_16880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KAM643c_16900	COG1902	pentaerythritol trinitrate reductase activity
KAM643c_16910	COG1253	flavin adenine dinucleotide binding
KAM643c_16940	COG0277	FAD linked oxidase domain protein
KAM643c_16940	COG0247	lactate metabolic process
KAM643c_16960	COG2050	protein possibly involved in aromatic compounds catabolism
KAM643c_16990	COG5001	Diguanylate cyclase
KAM643c_17000	COG0583	DNA-binding transcription factor activity
KAM643c_17010	COG2814	Major facilitator Superfamily
KAM643c_17020	COG2056	Na+-H+ antiporter family
KAM643c_17030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM643c_17070	COG0483	inositol monophosphate 1-phosphatase activity
KAM643c_17090	COG0625	glutathione transferase activity
KAM643c_17100	COG0625	glutathione transferase activity
KAM643c_17120	COG0601	transmembrane transport
KAM643c_17130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM643c_17140	COG0444	Belongs to the ABC transporter superfamily
KAM643c_17150	COG2814	Major facilitator Superfamily
KAM643c_17190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM643c_17200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM643c_17210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KAM643c_17220	COG0509	glycine decarboxylation via glycine cleavage system
KAM643c_17230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAM643c_17230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAM643c_17280	COG3634	alkyl hydroperoxide reductase activity
KAM643c_17290	COG0450	alkyl hydroperoxide reductase
KAM643c_17300	COG0517	IMP dehydrogenase activity
KAM643c_17310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KAM643c_17320	COG0343	queuine tRNA-ribosyltransferase activity
KAM643c_17330	COG1862	Preprotein translocase
KAM643c_17340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM643c_17350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM643c_17360	COG2897	thiosulfate sulfurtransferase activity
KAM643c_17380	COG0826	peptidase U32
KAM643c_17390	COG0826	peptidase U32
KAM643c_17400	COG3154	lipid carrier protein
KAM643c_17430	COG1104	cysteine desulfurase activity
KAM643c_17440	COG0822	iron-sulfur transferase activity
KAM643c_17460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAM643c_17470	COG0443	Heat shock 70 kDa protein
KAM643c_17480	COG0633	Ferredoxin
KAM643c_17510	COG0105	UTP biosynthetic process
KAM643c_17520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KAM643c_17540	COG1426	Protein conserved in bacteria
KAM643c_17560	COG0124	histidyl-tRNA synthetase
KAM643c_17570	COG2976	Protein conserved in bacteria
KAM643c_17580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM643c_17590	COG1160	GTP binding
KAM643c_17600	COG1645	bacterial-type flagellum-dependent swarming motility
KAM643c_17620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KAM643c_17630	COG0047	phosphoribosylformylglycinamidine synthase activity
KAM643c_17630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAM643c_17640	COG1007	ATP synthesis coupled electron transport
KAM643c_17650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM643c_17670	COG0713	ATP synthesis coupled electron transport
KAM643c_17680	COG0839	Belongs to the complex I subunit 6 family
KAM643c_17690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM643c_17700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KAM643c_17710	COG1034	ATP synthesis coupled electron transport
KAM643c_17740	COG0649	NAD binding
KAM643c_17740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM643c_17750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM643c_17760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAM643c_17770	COG1360	Flagellar Motor Protein
KAM643c_17780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM643c_17800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_17850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KAM643c_17870	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KAM643c_17890	COG0724	RNA recognition motif
KAM643c_17900	COG4989	oxidoreductase activity
KAM643c_17950	COG0745	RESPONSE REGULATOR receiver
KAM643c_17960	COG0583	DNA-binding transcription factor activity
KAM643c_17980	COG3300	MHYT domain
KAM643c_17980	COG5001	Diguanylate cyclase
KAM643c_17990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KAM643c_18050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAM643c_18060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KAM643c_18070	COG0539	negative regulation of cytoplasmic translation
KAM643c_18080	COG0776	regulation of translation
KAM643c_18100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KAM643c_18140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KAM643c_18150	COG0602	queuosine metabolic process
KAM643c_18160	COG3530	Putative quorum-sensing-regulated virulence factor
KAM643c_18170	COG2096	Adenosyltransferase
KAM643c_18180	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAM643c_18190	COG1757	Na H antiporter
KAM643c_18200	COG1435	thymidine kinase activity
KAM643c_18240	COG1737	Transcriptional regulator
KAM643c_18250	COG1263	PTS System
KAM643c_18250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_18250	COG2190	(PTS) system
KAM643c_18260	COG2723	6-phospho-beta-galactosidase activity
KAM643c_18290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KAM643c_18300	COG3550	peptidyl-serine autophosphorylation
KAM643c_18450	COG3039	Transposase
KAM643c_18480	COG4584	PFAM Integrase catalytic
KAM643c_18490	COG1484	DNA-dependent DNA replication
KAM643c_18500	COG2197	response regulator
KAM643c_18570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KAM643c_18720	COG0629	single-stranded DNA binding
KAM643c_18730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM643c_18740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAM643c_18750	COG1397	ADP-ribosylglycohydrolase
KAM643c_18780	COG3335	DDE superfamily endonuclease
KAM643c_18830	COG3385	transposase activity
KAM643c_18960	COG3039	Transposase
KAM643c_19030	COG0071	Belongs to the small heat shock protein (HSP20) family
KAM643c_19040	COG0542	response to heat
KAM643c_19060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAM643c_19120	COG0501	Belongs to the peptidase M48B family
KAM643c_19130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAM643c_19260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KAM643c_19270	COG0626	cystathionine gamma-synthase activity
KAM643c_19300	COG2910	NAD(P)H-binding
KAM643c_19310	COG0583	DNA-binding transcription factor activity
KAM643c_19320	COG1917	Cupin 2, conserved barrel domain protein
KAM643c_19320	COG4977	sequence-specific DNA binding
KAM643c_19330	COG2200	EAL domain
KAM643c_19340	COG2203	Gaf domain
KAM643c_19340	COG2199	diguanylate cyclase activity
KAM643c_19350	COG4774	siderophore transport
KAM643c_19370	COG0583	DNA-binding transcription factor activity
KAM643c_19380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KAM643c_19400	COG0617	tRNA 3'-terminal CCA addition
KAM643c_19400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KAM643c_19400	COG0517	IMP dehydrogenase activity
KAM643c_19430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM643c_19440	COG3046	protein related to deoxyribodipyrimidine photolyase
KAM643c_19460	COG3088	subunit of a heme lyase
KAM643c_19460	COG4235	cytochrome complex assembly
KAM643c_19470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM643c_19490	COG3301	Polysulphide reductase, NrfD
KAM643c_19500	COG0437	4 iron, 4 sulfur cluster binding
KAM643c_19510	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KAM643c_19540	COG0247	lactate metabolic process
KAM643c_19550	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KAM643c_19560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KAM643c_19570	COG3012	SEC-C Motif Domain Protein
KAM643c_19580	COG0840	transmembrane signaling receptor activity
KAM643c_19590	COG1940	carbohydrate kinase activity
KAM643c_19590	COG1846	Transcriptional regulator
KAM643c_19600	COG3290	protein histidine kinase activity
KAM643c_19610	COG4565	transcriptional regulatory protein
KAM643c_19640	COG3181	Tripartite tricarboxylate transporter family receptor
KAM643c_19650	COG0739	heme binding
KAM643c_19650	COG0741	lytic transglycosylase activity
KAM643c_19650	COG1196	nuclear chromosome segregation
KAM643c_19670	COG0569	domain protein
KAM643c_19670	COG2985	domain, Protein
KAM643c_19690	COG0556	nucleotide-excision repair
KAM643c_19710	COG0586	Pfam SNARE associated Golgi protein
KAM643c_19720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KAM643c_19730	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAM643c_19740	COG2186	Transcriptional regulator
KAM643c_19760	COG2719	SpoVR family
KAM643c_19770	COG2718	Belongs to the UPF0229 family
KAM643c_19780	COG2766	serine protein kinase
KAM643c_19790	COG0514	ATP-dependent DNA helicase (RecQ)
KAM643c_19800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KAM643c_19820	COG0814	amino acid
KAM643c_19880	COG0058	SHG alpha-glucan phosphorylase activity
KAM643c_19900	COG0471	metal ion transport
KAM643c_19910	COG3118	belongs to the thioredoxin family
KAM643c_19930	COG1132	(ABC) transporter
KAM643c_19940	COG1132	(ABC) transporter
KAM643c_19990	COG2501	S4 domain
KAM643c_20010	COG3243	poly(R)-hydroxyalkanoic acid synthase
KAM643c_20070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KAM643c_20080	COG2329	Antibiotic biosynthesis monooxygenase
KAM643c_20130	COG1742	UPF0060 membrane protein
KAM643c_20160	COG0513	Belongs to the DEAD box helicase family
KAM643c_20170	COG0386	Belongs to the glutathione peroxidase family
KAM643c_20190	COG1181	Belongs to the D-alanine--D-alanine ligase family
KAM643c_20200	COG3148	PFAM DTW domain containing protein
KAM643c_20210	COG0730	response to heat
KAM643c_20220	COG0583	DNA-binding transcription factor activity
KAM643c_20250	COG3593	DNA synthesis involved in DNA repair
KAM643c_20270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAM643c_20280	COG1011	Hydrolase
KAM643c_20290	COG1473	amidohydrolase
KAM643c_20310	COG0205	6-phosphofructokinase activity
KAM643c_20330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KAM643c_20340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM643c_20360	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KAM643c_20370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KAM643c_20430	COG0588	phosphoglycerate mutase activity
KAM643c_20450	COG0675	Transposase, IS605 OrfB family
KAM643c_20490	COG2824	Alkylphosphonate utilization operon protein PhnA
KAM643c_20580	COG2840	Smr protein MutS2
KAM643c_20590	COG2890	protein-(glutamine-N5) methyltransferase activity
KAM643c_20600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KAM643c_20620	COG0513	Belongs to the DEAD box helicase family
KAM643c_20630	COG5654	RES domain protein
KAM643c_20650	COG0814	amino acid
KAM643c_20660	COG1609	Transcriptional regulator
KAM643c_20670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_20670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_20680	COG1105	Belongs to the carbohydrate kinase PfkB family
KAM643c_20690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAM643c_20690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAM643c_20690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KAM643c_20700	COG3313	Fe-S protein
KAM643c_20710	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KAM643c_20720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KAM643c_20730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM643c_20740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAM643c_20760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM643c_20810	COG0675	Transposase, IS605 OrfB family
KAM643c_20850	COG5433	transposase activity
KAM643c_20940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KAM643c_20950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KAM643c_20960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KAM643c_20970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KAM643c_20980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KAM643c_20990	COG0072	phenylalanine-tRNA ligase activity
KAM643c_20990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM643c_21000	COG0776	regulation of translation
KAM643c_21070	COG3300	MHYT domain
KAM643c_21070	COG5001	Diguanylate cyclase
KAM643c_21100	COG1609	Transcriptional regulator
KAM643c_21110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM643c_21120	COG1879	ABC-type sugar transport system periplasmic component
KAM643c_21130	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM643c_21140	COG1129	ABC transporter
KAM643c_21150	COG1869	D-ribose catabolic process
KAM643c_21160	COG0625	glutathione transferase activity
KAM643c_21190	COG0037	tRNA processing
KAM643c_21200	COG0589	response to stress
KAM643c_21210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KAM643c_21240	COG2217	Heavy metal translocating P-type atpase
KAM643c_21260	COG2010	Cytochrome c
KAM643c_21290	COG3278	Belongs to the heme-copper respiratory oxidase family
KAM643c_21310	COG1956	GAF domain-containing protein
KAM643c_21320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KAM643c_21340	COG0308	aminopeptidase N
KAM643c_21360	COG2902	Dehydrogenase
KAM643c_21370	COG0167	dihydroorotate dehydrogenase activity
KAM643c_21390	COG0116	Belongs to the methyltransferase superfamily
KAM643c_21390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAM643c_21410	COG0488	(ABC) transporter
KAM643c_21440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAM643c_21450	COG1067	ATP-dependent peptidase activity
KAM643c_21470	COG3141	response to X-ray
KAM643c_21500	COG2995	paraquat-inducible protein a
KAM643c_21510	COG3008	intermembrane lipid transfer
KAM643c_21520	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KAM643c_21520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM643c_21550	COG0084	hydrolase, TatD family'
KAM643c_21560	COG0470	DNA polymerase III
KAM643c_21570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KAM643c_21580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KAM643c_21590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAM643c_21600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAM643c_21610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAM643c_21620	COG1028	Short-chain dehydrogenase reductase Sdr
KAM643c_21640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAM643c_21650	COG0416	fatty acid biosynthetic process
KAM643c_21660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KAM643c_21670	COG1399	metal-binding, possibly nucleic acid-binding protein
KAM643c_21710	COG0564	pseudouridine synthase activity
KAM643c_21720	COG1530	ribonuclease E activity
KAM643c_21770	COG0840	transmembrane signaling receptor activity
KAM643c_21780	COG1484	DNA-dependent DNA replication
KAM643c_21790	COG4584	PFAM Integrase catalytic
KAM643c_21800	COG3385	transposase activity
KAM643c_21930	COG0625	glutathione transferase activity
KAM643c_21940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM643c_21960	COG0583	DNA-binding transcription factor activity
KAM643c_21990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM643c_22020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAM643c_22060	COG1846	Transcriptional regulator
KAM643c_22070	COG0583	DNA-binding transcription factor activity
KAM643c_22090	COG2948	multi-organism process
KAM643c_22200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_22230	COG0306	phosphate transporter
KAM643c_22240	COG0717	Belongs to the dCTP deaminase family
KAM643c_22250	COG0572	uridine kinase
KAM643c_22260	COG0489	protein tyrosine kinase activity
KAM643c_22270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM643c_22270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM643c_22300	COG1254	Belongs to the acylphosphatase family
KAM643c_22310	COG0840	transmembrane signaling receptor activity
KAM643c_22320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAM643c_22360	COG0709	Synthesizes selenophosphate from selenide and ATP
KAM643c_22370	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KAM643c_22380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAM643c_22390	COG3437	response regulator, receiver
KAM643c_22420	COG0675	Transposase, IS605 OrfB family
KAM643c_22440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KAM643c_22460	COG1643	Atp-dependent helicase
KAM643c_22470	COG0517	IMP dehydrogenase activity
KAM643c_22470	COG0617	tRNA 3'-terminal CCA addition
KAM643c_22470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KAM643c_22480	COG2197	response regulator
KAM643c_22490	COG3039	Transposase
KAM643c_22500	COG3385	transposase activity
KAM643c_22510	COG3314	Sporulation integral membrane protein YlbJ
KAM643c_22540	COG5433	transposase activity
KAM643c_22640	COG3621	Patatin-like phospholipase
KAM643c_22700	COG0697	spore germination
KAM643c_22740	COG3077	Addiction module antitoxin, RelB DinJ family
KAM643c_22750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM643c_22780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM643c_22840	COG3039	Transposase
KAM643c_22870	COG0583	DNA-binding transcription factor activity
KAM643c_22880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KAM643c_22900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KAM643c_22910	COG2832	Protein of unknown function (DUF454)
KAM643c_22920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM643c_22940	COG0697	spore germination
KAM643c_22960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KAM643c_22970	COG0318	PFAM AMP-dependent synthetase and ligase
KAM643c_22980	COG0596	Alpha beta hydrolase
KAM643c_23000	COG1214	PFAM Peptidase M22, glycoprotease
KAM643c_23010	COG1199	ATP-dependent helicase activity
KAM643c_23020	COG1199	ATP-dependent helicase activity
KAM643c_23040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KAM643c_23050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KAM643c_23060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KAM643c_23070	COG0131	Imidazoleglycerol-phosphate dehydratase
KAM643c_23070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAM643c_23080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KAM643c_23090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KAM643c_23100	COG3437	response regulator, receiver
KAM643c_23110	COG2199	diguanylate cyclase activity
KAM643c_23120	COG0784	Response regulator, receiver
KAM643c_23120	COG2198	Histidine kinase
KAM643c_23120	COG2205	protein histidine kinase activity
KAM643c_23130	COG0107	imidazoleglycerol-phosphate synthase activity
KAM643c_23140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KAM643c_23140	COG0140	phosphoribosyl-ATP diphosphatase activity
KAM643c_23160	COG2378	regulation of single-species biofilm formation
KAM643c_23170	COG0318	PFAM AMP-dependent synthetase and ligase
KAM643c_23180	COG0675	Transposase, IS605 OrfB family
KAM643c_23200	COG3134	Outer membrane lipoprotein
KAM643c_23230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM643c_23270	COG3335	DDE superfamily endonuclease
KAM643c_23280	COG3385	transposase activity
KAM643c_23300	COG4681	YaeQ
KAM643c_23320	COG1024	Enoyl-CoA hydratase
KAM643c_23320	COG1250	3-hydroxyacyl-CoA dehydrogenase
KAM643c_23330	COG0183	Belongs to the thiolase family
KAM643c_23340	COG0714	Associated with various cellular activities
KAM643c_23380	COG2304	oxidoreductase activity
KAM643c_23410	COG1595	DNA-templated transcription, initiation
KAM643c_23430	COG2067	long-chain fatty acid transport protein
KAM643c_23440	COG2067	long-chain fatty acid transport protein
KAM643c_23450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KAM643c_23480	COG1301	dicarboxylic acid transport
KAM643c_23490	COG3123	guanosine phosphorylase activity
KAM643c_23500	COG1760	l-serine dehydratase
KAM643c_23510	COG1760	l-serine dehydratase
KAM643c_23520	COG3385	transposase activity
KAM643c_23530	COG2951	lytic endotransglycosylase activity
KAM643c_23540	COG3100	YcgL domain-containing protein
KAM643c_23550	COG0850	regulation of cytokinetic process
KAM643c_23560	COG2894	cell division
KAM643c_23570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KAM643c_23580	COG3099	Belongs to the UPF0263 family
KAM643c_23590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KAM643c_23620	COG2996	Protein conserved in bacteria
KAM643c_23630	COG0675	Transposase, IS605 OrfB family
KAM643c_23690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KAM643c_23700	COG0697	spore germination
KAM643c_23710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KAM643c_23720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM643c_23750	COG0307	riboflavin synthase, alpha
KAM643c_23770	COG0534	Mate efflux family protein
KAM643c_23860	COG0417	DNA replication proofreading
KAM643c_23890	COG1560	Kdo2-lipid A biosynthetic process
KAM643c_23900	COG1560	Kdo2-lipid A biosynthetic process
KAM643c_23920	COG0583	DNA-binding transcription factor activity
KAM643c_23930	COG0673	inositol 2-dehydrogenase activity
KAM643c_23940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KAM643c_23970	COG0583	DNA-binding transcription factor activity
KAM643c_23980	COG5433	transposase activity
KAM643c_23990	COG0583	DNA-binding transcription factor activity
KAM643c_24010	COG2723	6-phospho-beta-galactosidase activity
KAM643c_24020	COG0583	DNA-binding transcription factor activity
KAM643c_24050	COG0243	molybdopterin cofactor binding
KAM643c_24060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KAM643c_24090	COG0583	DNA-binding transcription factor activity
KAM643c_24100	COG1129	ABC transporter
KAM643c_24110	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM643c_24120	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM643c_24150	COG0702	epimerase
KAM643c_24160	COG1073	alpha beta
KAM643c_24170	COG1073	alpha beta
KAM643c_24260	COG2003	Belongs to the UPF0758 family
KAM643c_24340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KAM643c_24370	COG0730	response to heat
KAM643c_24390	COG1028	Short-chain dehydrogenase reductase Sdr
KAM643c_24410	COG1024	Enoyl-CoA hydratase
KAM643c_24430	COG1024	Enoyl-CoA hydratase
KAM643c_24440	COG1960	acyl-CoA dehydrogenase activity
KAM643c_24460	COG1960	acyl-CoA dehydrogenase activity
KAM643c_24470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KAM643c_24480	COG1024	Enoyl-CoA hydratase
KAM643c_24530	COG1584	GPR1 FUN34 yaaH family protein
KAM643c_24540	COG3228	Belongs to the MtfA family
KAM643c_24560	COG1115	amino acid carrier protein
KAM643c_24570	COG1024	Enoyl-CoA hydratase
KAM643c_24600	COG3162	membrane
KAM643c_24610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAM643c_24620	COG0488	(ABC) transporter
KAM643c_24630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAM643c_24640	COG0776	regulation of translation
KAM643c_24650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KAM643c_24660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KAM643c_24670	COG0740	serine-type endopeptidase activity
KAM643c_24680	COG0544	peptidyl-prolyl cis-trans isomerase activity
KAM643c_24700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KAM643c_24710	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAM643c_24720	COG1136	(ABC) transporter
KAM643c_24730	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAM643c_24750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KAM643c_24760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KAM643c_24780	COG0697	spore germination
KAM643c_24800	COG2062	phosphohistidine phosphatase, SixA
KAM643c_24820	COG0500	methyltransferase
KAM643c_24840	COG1846	Transcriptional regulator
KAM643c_24900	COG2801	Transposase and inactivated derivatives
KAM643c_24920	COG2801	Transposase and inactivated derivatives
KAM643c_24970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAM643c_24970	COG0519	Catalyzes the synthesis of GMP from XMP
KAM643c_24980	COG0516	GMP reductase activity
KAM643c_24980	COG0517	IMP dehydrogenase activity
KAM643c_25010	COG0366	Alpha amylase catalytic
KAM643c_25010	COG1874	Beta-galactosidase
KAM643c_25040	COG1570	exodeoxyribonuclease VII activity
KAM643c_25060	COG2885	chlorophyll binding
KAM643c_25100	COG2154	pterin-4-alpha-carbinolamine dehydratase
KAM643c_25120	COG3768	UPF0283 membrane protein
KAM643c_25130	COG3106	COG3106 Predicted ATPase
KAM643c_25160	COG1842	Phage shock protein A
KAM643c_25170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KAM643c_25210	COG4171	peptide transport system, permease
KAM643c_25230	COG4172	Belongs to the ABC transporter superfamily
KAM643c_25250	COG1609	Transcriptional regulator
KAM643c_25260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_25260	COG1263	PTS System
KAM643c_25270	COG2723	6-phospho-beta-galactosidase activity
KAM643c_25280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KAM643c_25290	COG1286	toxin biosynthetic process
KAM643c_25300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KAM643c_25310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KAM643c_25320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KAM643c_25330	COG0531	amino acid
KAM643c_25330	COG1674	ftsk spoiiie
KAM643c_25350	COG0686	Belongs to the AlaDH PNT family
KAM643c_25360	COG0492	ferredoxin-NADP+ reductase activity
KAM643c_25370	COG3706	GGDEF domain
KAM643c_25380	COG3134	Outer membrane lipoprotein
KAM643c_25390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KAM643c_25400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KAM643c_25410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KAM643c_25420	COG0542	response to heat
KAM643c_25430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KAM643c_25440	COG1278	Cold shock
KAM643c_25450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAM643c_25480	COG1944	ATP diphosphatase activity
KAM643c_25490	COG2116	formate transmembrane transporter activity
KAM643c_25500	COG1882	Formate acetyltransferase
KAM643c_25510	COG2983	Belongs to the UPF0260 family
KAM643c_25530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KAM643c_25540	COG0045	succinate-CoA ligase (ADP-forming) activity
KAM643c_25550	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAM643c_25560	COG0567	Dehydrogenase, E1 component
KAM643c_25590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KAM643c_25600	COG2009	succinate dehydrogenase
KAM643c_25640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAM643c_25650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM643c_25650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KAM643c_25670	COG3069	C4-dicarboxylate transmembrane transporter activity
KAM643c_25700	COG1451	nucleotide metabolic process
KAM643c_25730	COG0254	rRNA binding
KAM643c_25750	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM643c_25760	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAM643c_25770	COG1129	ABC transporter
KAM643c_25780	COG1879	ABC-type sugar transport system periplasmic component
KAM643c_25790	COG1069	ribulokinase activity
KAM643c_25810	COG2160	L-arabinose isomerase activity
KAM643c_25820	COG0583	DNA-binding transcription factor activity
KAM643c_25830	COG0436	Aminotransferase
KAM643c_25840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAM643c_25870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KAM643c_25870	COG0392	lysyltransferase activity
KAM643c_25880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KAM643c_26100	COG4626	Terminase
KAM643c_26100	COG1802	Transcriptional regulator
KAM643c_26210	COG3646	Phage regulatory protein
KAM643c_26240	COG1846	Transcriptional regulator
KAM643c_26280	COG1396	sequence-specific DNA binding
KAM643c_26440	COG0582	viral genome integration into host DNA
KAM643c_26450	COG2925	Exonuclease
KAM643c_26470	COG3345	alpha-galactosidase
KAM643c_26480	COG1380	Effector of murein hydrolase LrgA
KAM643c_26490	COG1346	cytolysis
KAM643c_26500	COG0295	cytidine deaminase activity
KAM643c_26510	COG1022	Amp-dependent synthetase and ligase
KAM643c_26540	COG0861	Integral membrane protein TerC family
KAM643c_26550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM643c_26560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KAM643c_26570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KAM643c_26650	COG4771	TonB-dependent receptor
KAM643c_26660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM643c_26670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAM643c_26680	COG1120	ATPase activity
KAM643c_26720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAM643c_26740	COG1028	Short-chain dehydrogenase reductase Sdr
KAM643c_26750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAM643c_26760	COG3433	isochorismatase activity
KAM643c_26760	COG1535	isochorismatase
KAM643c_26770	COG1021	2,3-dihydroxybenzoate-AMP ligase
KAM643c_26820	COG5001	Diguanylate cyclase
KAM643c_26820	COG3300	MHYT domain
KAM643c_26850	COG0840	transmembrane signaling receptor activity
KAM643c_26860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM643c_26870	COG3788	relative of glutathione S-transferase, MAPEG superfamily
KAM643c_26880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KAM643c_26890	COG0563	adenylate kinase activity
KAM643c_26900	COG0326	Molecular chaperone. Has ATPase activity
KAM643c_26920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KAM643c_26970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_27010	COG0659	secondary active sulfate transmembrane transporter activity
KAM643c_27020	COG3335	DDE superfamily endonuclease
KAM643c_27030	COG2308	Evidence 4 Homologs of previously reported genes of
KAM643c_27110	COG0672	)-iron permease
KAM643c_27160	COG2814	Major facilitator Superfamily
KAM643c_27200	COG1136	(ABC) transporter
KAM643c_27210	COG0577	efflux transmembrane transporter activity
KAM643c_27250	COG1139	Iron-sulfur cluster binding protein
KAM643c_27260	COG0247	lactate metabolic process
KAM643c_27270	COG1620	l-lactate permease
KAM643c_27280	COG0583	DNA-binding transcription factor activity
KAM643c_27330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAM643c_27340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAM643c_27340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KAM643c_27360	COG0527	aspartate kinase activity
KAM643c_27380	COG1368	sulfuric ester hydrolase activity
KAM643c_27390	COG0393	Putative heavy-metal-binding
KAM643c_27400	COG1252	NADH dehydrogenase
KAM643c_27410	COG3150	esterase
KAM643c_27420	COG1164	Oligoendopeptidase f
KAM643c_27430	COG1164	Oligoendopeptidase f
KAM643c_27440	COG2354	Protein conserved in bacteria
KAM643c_27470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM643c_27480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAM643c_27550	COG0537	adenosine 5'-monophosphoramidase activity
KAM643c_27580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAM643c_27610	COG1301	dicarboxylic acid transport
KAM643c_27630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAM643c_27640	COG0861	Integral membrane protein TerC family
KAM643c_27660	COG0444	Belongs to the ABC transporter superfamily
KAM643c_27670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM643c_27680	COG0601	transmembrane transport
KAM643c_27700	COG2095	MarC family integral membrane protein
KAM643c_27710	COG1012	belongs to the aldehyde dehydrogenase family
KAM643c_27710	COG1454	alcohol dehydrogenase
KAM643c_27730	COG3275	phosphorelay sensor kinase activity
KAM643c_27740	COG3279	Response regulator of the LytR AlgR family
KAM643c_27750	COG1966	Carbon starvation protein
KAM643c_27760	COG3264	Mechanosensitive ion channel
KAM643c_27760	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KAM643c_27780	COG1566	PFAM secretion protein HlyD family protein
KAM643c_27790	COG1061	Type III restriction enzyme res subunit
KAM643c_27800	COG2027	D-alanyl-D-alanine carboxypeptidase
KAM643c_27810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAM643c_27830	COG0436	Aminotransferase
KAM643c_27840	COG1288	antiporter activity
KAM643c_27860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAM643c_27900	COG0697	spore germination
KAM643c_27910	COG0675	Transposase, IS605 OrfB family
KAM643c_27920	COG4657	Part of a membrane complex involved in electron transport
KAM643c_27930	COG2878	Part of a membrane complex involved in electron transport
KAM643c_27950	COG4658	electron transport chain
KAM643c_27960	COG4659	FMN binding
KAM643c_27970	COG4660	Part of a membrane complex involved in electron transport
KAM643c_27980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KAM643c_27990	COG0346	lactoylglutathione lyase activity
KAM643c_28030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KAM643c_28050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KAM643c_28060	COG1086	Polysaccharide biosynthesis protein
KAM643c_28070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KAM643c_28090	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KAM643c_28100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KAM643c_28130	COG2089	acid synthase
KAM643c_28210	COG1334	flagellar protein FlaG
KAM643c_28220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM643c_28230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAM643c_28260	COG0301	tRNA thio-modification
KAM643c_28260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM643c_28280	COG4953	penicillin-binding protein 1C
KAM643c_28290	COG2373	Large extracellular alpha-helical protein
KAM643c_28300	COG0628	permease
KAM643c_28310	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM643c_28330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KAM643c_28350	COG4160	amino acid transport
KAM643c_28370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_28390	COG2431	L-lysine efflux transmembrane transporter activity
KAM643c_28410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KAM643c_28420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_28470	COG1393	Belongs to the ArsC family
KAM643c_28490	COG4783	chaperone-mediated protein folding
KAM643c_28500	COG0425	Belongs to the sulfur carrier protein TusA family
KAM643c_28550	COG3842	ATPase activity
KAM643c_28560	COG3833	ABC-type maltose transport systems, permease component
KAM643c_28570	COG1175	transmembrane transport
KAM643c_28590	COG3081	Nucleoid-associated protein
KAM643c_28600	COG3082	Protein of unknown function (DUF1414)
KAM643c_28610	COG3083	sulfuric ester hydrolase activity
KAM643c_28620	COG4771	TonB-dependent receptor
KAM643c_28630	COG1770	oligopeptidase
KAM643c_28670	COG4574	serine-type endopeptidase inhibitor activity
KAM643c_28680	COG3085	chromosome segregation
KAM643c_28700	COG0287	Prephenate dehydrogenase
KAM643c_28700	COG1605	Chorismate mutase
KAM643c_28710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAM643c_28720	COG0584	glycerophosphoryl diester phosphodiesterase
KAM643c_28750	COG1349	DNA-binding transcription factor activity
KAM643c_28760	COG2271	Major facilitator Superfamily
KAM643c_28770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KAM643c_28780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KAM643c_28790	COG0583	DNA-binding transcription factor activity
KAM643c_28830	COG0656	L-ascorbic acid biosynthetic process
KAM643c_28840	COG2814	Major facilitator Superfamily
KAM643c_28850	COG1294	oxidase, subunit
KAM643c_28860	COG1271	oxidase subunit
KAM643c_28870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM643c_28890	COG2979	Protein of unknown function (DUF533)
KAM643c_28930	COG0583	DNA-binding transcription factor activity
KAM643c_28950	COG2807	transmembrane transport
KAM643c_28960	COG1187	pseudouridine synthase activity
KAM643c_28970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KAM643c_28990	COG2801	Transposase and inactivated derivatives
KAM643c_29030	COG1061	Type III restriction enzyme res subunit
KAM643c_29070	COG1166	arginine decarboxylase activity
KAM643c_29080	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAM643c_29110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KAM643c_29120	COG3385	transposase activity
KAM643c_29160	COG0583	DNA-binding transcription factor activity
KAM643c_29190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KAM643c_29200	COG0840	transmembrane signaling receptor activity
KAM643c_29210	COG0302	gtp cyclohydrolase
KAM643c_29230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAM643c_29240	COG2267	carboxylic ester hydrolase activity
KAM643c_29250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KAM643c_29280	COG0314	molybdopterin synthase activity
KAM643c_29290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KAM643c_29300	COG0315	cyclic pyranopterin monophosphate synthase activity
KAM643c_29310	COG0521	Mo-molybdopterin cofactor biosynthetic process
KAM643c_29320	COG3005	denitrification pathway
KAM643c_29340	COG0348	domain, Protein
KAM643c_29350	COG0437	4 iron, 4 sulfur cluster binding
KAM643c_29360	COG0243	molybdopterin cofactor binding
KAM643c_29380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM643c_29380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM643c_29390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KAM643c_29400	COG3850	Histidine kinase
KAM643c_29410	COG2197	response regulator
KAM643c_29460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KAM643c_29480	COG0121	glutamine amidotransferase
KAM643c_29490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAM643c_29500	COG1960	acyl-CoA dehydrogenase activity
KAM643c_29510	COG0784	Response regulator, receiver
KAM643c_29510	COG3437	response regulator, receiver
KAM643c_29530	COG0784	Response regulator, receiver
KAM643c_29530	COG3437	response regulator, receiver
KAM643c_29550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAM643c_29560	COG0328	RNA-DNA hybrid ribonuclease activity
KAM643c_29570	COG2226	methyltransferase
KAM643c_29580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAM643c_29590	COG1388	LysM domain
KAM643c_29590	COG0741	lytic transglycosylase activity
KAM643c_29620	COG1607	acyl-coa hydrolase
KAM643c_29650	COG0741	lytic transglycosylase activity
KAM643c_29670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KAM643c_29690	COG2911	Protein conserved in bacteria
KAM643c_29700	COG0729	surface antigen
KAM643c_29720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAM643c_29750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KAM643c_29760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAM643c_29770	COG4134	Bacterial extracellular solute-binding protein
KAM643c_29790	COG4136	ATPase activity
KAM643c_29800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KAM643c_29810	COG2951	lytic endotransglycosylase activity
KAM643c_29820	COG3385	transposase activity
KAM643c_29830	COG1846	Transcriptional regulator
KAM643c_29850	COG0033	Phosphoglucomutase
KAM643c_29860	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KAM643c_29870	COG0596	Alpha beta hydrolase
KAM643c_29900	COG0716	FMN binding
KAM643c_29920	COG0735	belongs to the Fur family
KAM643c_29930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM643c_29950	COG1263	PTS System
KAM643c_29950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_29950	COG2190	(PTS) system
KAM643c_29960	COG0363	glucosamine-6-phosphate deaminase activity
KAM643c_29970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KAM643c_29980	COG1846	Transcriptional regulator
KAM643c_29980	COG1940	carbohydrate kinase activity
KAM643c_29990	COG2194	sulfuric ester hydrolase activity
KAM643c_30000	COG0217	transcriptional regulatory protein
KAM643c_30010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KAM643c_30020	COG1801	Protein of unknown function DUF72
KAM643c_30030	COG4106	trans-aconitate 2-methyltransferase activity
KAM643c_30040	COG0500	methyltransferase
KAM643c_30080	COG0583	DNA-binding transcription factor activity
KAM643c_30090	COG0791	NLP P60 protein
KAM643c_30120	COG1309	transcriptional regulator
KAM643c_30140	COG1454	alcohol dehydrogenase
KAM643c_30190	COG0534	Mate efflux family protein
KAM643c_30210	COG2841	Protein conserved in bacteria
KAM643c_30220	COG0674	pyruvate-flavodoxin oxidoreductase activity
KAM643c_30220	COG1013	pyruvate-flavodoxin oxidoreductase activity
KAM643c_30220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KAM643c_30220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KAM643c_30240	COG3217	Mosc domain protein beta barrel domain protein
KAM643c_30240	COG0633	Ferredoxin
KAM643c_30240	COG3217	Mosc domain protein beta barrel domain protein
KAM643c_30240	COG0633	Ferredoxin
KAM643c_30250	COG0501	Belongs to the peptidase M48B family
KAM643c_30260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KAM643c_30270	COG1073	alpha beta
KAM643c_30270	COG2226	methyltransferase
KAM643c_30280	COG0156	8-amino-7-oxononanoate synthase activity
KAM643c_30290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAM643c_30340	COG0017	Asparaginyl-tRNA synthetase
KAM643c_30350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAM643c_30370	COG1473	amidohydrolase
KAM643c_30380	COG3069	C4-dicarboxylate transmembrane transporter activity
KAM643c_30420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_30440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_30450	COG1393	Belongs to the ArsC family
KAM643c_30460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KAM643c_30470	COG1876	peptidase activity
KAM643c_30490	COG3263	regulation of cellular component size
KAM643c_30510	COG1280	lysine exporter protein (LysE YggA)
KAM643c_30560	COG1957	nucleoside hydrolase
KAM643c_30590	COG1454	alcohol dehydrogenase
KAM643c_30600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM643c_30610	COG0702	epimerase
KAM643c_30620	COG2914	Belongs to the UPF0125 (RnfH) family
KAM643c_30630	COG2867	negative regulation of translational initiation
KAM643c_30640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KAM643c_30650	COG0582	viral genome integration into host DNA
KAM643c_30670	COG1484	DNA-dependent DNA replication
KAM643c_30710	COG2194	sulfuric ester hydrolase activity
KAM643c_30720	COG3039	Transposase
KAM643c_30730	COG2194	sulfuric ester hydrolase activity
KAM643c_30750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KAM643c_30760	COG3039	Transposase
KAM643c_30780	COG3328	transposase activity
KAM643c_30830	COG2801	Transposase and inactivated derivatives
KAM643c_30870	COG4584	PFAM Integrase catalytic
KAM643c_30880	COG1484	DNA-dependent DNA replication
KAM643c_30900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAM643c_30910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KAM643c_31020	COG3311	Transcriptional regulator
KAM643c_31090	COG0246	Mannitol dehydrogenase
KAM643c_31100	COG2721	sulfolactate sulfo-lyase activity
KAM643c_31120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM643c_31130	COG0800	Aldolase
KAM643c_31160	COG3153	acetyltransferase
KAM643c_31220	COG0259	pyridoxamine-phosphate oxidase activity
KAM643c_31250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAM643c_31250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM643c_31260	COG3385	transposase activity
KAM643c_31270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KAM643c_31300	COG0457	Tetratricopeptide repeat
KAM643c_31320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM643c_31330	COG1138	Cytochrome C-type biogenesis protein
KAM643c_31340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KAM643c_31350	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM643c_31360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM643c_31370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAM643c_31400	COG0835	chemotaxis
KAM643c_31420	COG1192	Involved in chromosome partitioning
KAM643c_31430	COG1360	Flagellar Motor Protein
KAM643c_31440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM643c_31460	COG0643	Histidine kinase
KAM643c_31460	COG0784	Response regulator, receiver
KAM643c_31460	COG2198	Histidine kinase
KAM643c_31470	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KAM643c_31530	COG5433	transposase activity
KAM643c_31540	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KAM643c_31560	COG1684	flagellar biosynthetic protein fliR
KAM643c_31670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KAM643c_31690	COG1677	Flagellar hook-basal body complex protein FliE
KAM643c_31720	COG1393	Belongs to the ArsC family
KAM643c_31730	COG0798	PFAM Bile acid sodium symporter
KAM643c_31740	COG0640	Transcriptional regulator
KAM643c_31770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAM643c_31800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM643c_31810	COG0444	Belongs to the ABC transporter superfamily
KAM643c_31820	COG4608	Belongs to the ABC transporter superfamily
KAM643c_31840	COG2971	BadF BadG BcrA BcrD
KAM643c_31860	COG0840	transmembrane signaling receptor activity
KAM643c_31900	COG3724	N-succinylarginine dihydrolase activity
KAM643c_31910	COG0616	signal peptide processing
KAM643c_31920	COG1028	Short-chain dehydrogenase reductase Sdr
KAM643c_31930	COG0583	DNA-binding transcription factor activity
KAM643c_31950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KAM643c_31970	COG0583	DNA-binding transcription factor activity
KAM643c_31980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KAM643c_31990	COG1881	PFAM PEBP family protein
KAM643c_32010	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KAM643c_32010	COG3408	Glycogen debranching enzyme
KAM643c_32020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAM643c_32030	COG0739	heme binding
KAM643c_32040	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KAM643c_32090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KAM643c_32110	COG3091	SprT-like family
KAM643c_32130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KAM643c_32140	COG0189	ligase activity
KAM643c_32160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAM643c_32200	COG1115	amino acid carrier protein
KAM643c_32210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KAM643c_32240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KAM643c_32260	COG1301	dicarboxylic acid transport
KAM643c_32270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KAM643c_32280	COG2912	Transglutaminase-like superfamily
KAM643c_32300	COG2890	protein-(glutamine-N5) methyltransferase activity
KAM643c_32310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KAM643c_32320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KAM643c_32330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KAM643c_32340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KAM643c_32350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KAM643c_32360	COG0193	aminoacyl-tRNA hydrolase activity
KAM643c_32370	COG0012	GTP binding
KAM643c_32380	COG0471	metal ion transport
KAM643c_32380	COG0490	domain, Protein
KAM643c_32400	COG0657	acetylesterase activity
KAM643c_32430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM643c_32440	COG2801	Transposase and inactivated derivatives
KAM643c_32480	COG3039	Transposase
KAM643c_32520	COG3039	Transposase
KAM643c_32540	COG1012	belongs to the aldehyde dehydrogenase family
KAM643c_32560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KAM643c_32590	COG0180	Tryptophanyl-tRNA synthetase
KAM643c_32600	COG0546	phosphoglycolate phosphatase activity
KAM643c_32610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KAM643c_32620	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KAM643c_32640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KAM643c_32650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KAM643c_32710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAM643c_32720	COG0583	DNA-binding transcription factor activity
KAM643c_32750	COG0583	DNA-binding transcription factor activity
KAM643c_32780	COG0739	heme binding
KAM643c_32800	COG1511	domain protein
KAM643c_32800	COG3264	Mechanosensitive ion channel
KAM643c_32810	COG0584	glycerophosphoryl diester phosphodiesterase
KAM643c_32830	COG1053	succinate dehydrogenase
KAM643c_32840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KAM643c_32850	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KAM643c_32860	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KAM643c_32870	COG3385	transposase activity
KAM643c_32900	COG3214	Protein conserved in bacteria
KAM643c_32910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAM643c_32950	COG0300	oxidoreductase activity
KAM643c_33000	COG4067	protein conserved in archaea
KAM643c_33000	COG0189	ligase activity
KAM643c_33010	COG0516	GMP reductase activity
KAM643c_33030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAM643c_33040	COG2011	ABC-type metal ion transport system permease component
KAM643c_33050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAM643c_33060	COG1464	Belongs to the NlpA lipoprotein family
KAM643c_33090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAM643c_33110	COG2199	diguanylate cyclase activity
KAM643c_33130	COG2199	diguanylate cyclase activity
KAM643c_33140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM643c_33170	COG1278	Cold shock
KAM643c_33180	COG1335	isochorismatase
KAM643c_33190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAM643c_33200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAM643c_33210	COG1702	phosphate starvation-inducible protein PhoH
KAM643c_33220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KAM643c_33230	COG4535	Mg2 and Co2 transporter CorC
KAM643c_33240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KAM643c_33250	COG2888	peptidyl-tyrosine sulfation
KAM643c_33260	COG0495	leucyl-tRNA aminoacylation
KAM643c_33300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KAM643c_33310	COG0799	negative regulation of ribosome biogenesis
KAM643c_33320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KAM643c_33330	COG0768	penicillin binding
KAM643c_33340	COG0772	Belongs to the SEDS family
KAM643c_33350	COG2951	lytic endotransglycosylase activity
KAM643c_33360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KAM643c_33370	COG1686	Belongs to the peptidase S11 family
KAM643c_33380	COG2921	Belongs to the UPF0250 family
KAM643c_33390	COG0321	lipoyl(octanoyl) transferase activity
KAM643c_33400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KAM643c_33420	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAM643c_33450	COG0789	Transcriptional regulator
KAM643c_33480	COG1970	mechanosensitive ion channel activity
KAM643c_33490	COG4974	Belongs to the 'phage' integrase family
KAM643c_33510	COG0312	modulator of DNA gyrase
KAM643c_33520	COG0312	modulator of DNA gyrase
KAM643c_33560	COG0826	peptidase U32
KAM643c_33570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAM643c_33580	COG1422	Protein of unknown function (DUF1090)
KAM643c_33590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KAM643c_33600	COG2211	Major facilitator Superfamily
KAM643c_33610	COG1185	polyribonucleotide nucleotidyltransferase activity
KAM643c_33620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KAM643c_33630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KAM643c_33640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KAM643c_33650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KAM643c_33660	COG0195	Participates in both transcription termination and antitermination
KAM643c_33670	COG0779	Required for maturation of 30S ribosomal subunits
KAM643c_33680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAM643c_33690	COG0149	triose-phosphate isomerase activity
KAM643c_33700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KAM643c_33710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KAM643c_33730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KAM643c_33740	COG1534	Rna-binding protein
KAM643c_33770	COG1360	Flagellar Motor Protein
KAM643c_33780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAM643c_33790	COG1722	exodeoxyribonuclease VII activity
KAM643c_33800	COG0142	geranyltranstransferase activity
KAM643c_33810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KAM643c_33820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAM643c_33830	COG0601	transmembrane transport
KAM643c_33870	COG4172	Belongs to the ABC transporter superfamily
KAM643c_33880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KAM643c_33890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KAM643c_33900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAM643c_33910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KAM643c_33940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAM643c_33940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAM643c_33950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KAM643c_33970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAM643c_33990	COG3381	protein complex oligomerization
KAM643c_34030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAM643c_34040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KAM643c_34050	COG0511	ligase activity, forming carbon-carbon bonds
KAM643c_34060	COG0439	Biotin carboxylase
KAM643c_34070	COG3924	membrane
KAM643c_34080	COG4145	pantothenate transmembrane transporter activity
KAM643c_34090	COG2190	(PTS) system
KAM643c_34090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_34090	COG1263	PTS System
KAM643c_34100	COG0583	DNA-binding transcription factor activity
KAM643c_34110	COG0604	alcohol dehydrogenase
KAM643c_34120	COG2264	protein methyltransferase activity
KAM643c_34150	COG0778	Nitroreductase
KAM643c_34160	COG1902	pentaerythritol trinitrate reductase activity
KAM643c_34160	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM643c_34170	COG0616	signal peptide processing
KAM643c_34210	COG3139	Protein of unknown function (DUF1315)
KAM643c_34220	COG0252	asparaginase activity
KAM643c_34230	COG0786	glutamate:sodium symporter activity
KAM643c_34250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KAM643c_34260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KAM643c_34270	COG0384	phenazine biosynthesis protein PhzF
KAM643c_34280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KAM643c_34290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM643c_34300	COG0175	sulfate reduction
KAM643c_34310	COG2113	Glycine betaine
KAM643c_34320	COG4176	ABC-type proline glycine betaine transport system permease component
KAM643c_34330	COG4175	Glycine betaine
KAM643c_34350	COG3610	response to peptide
KAM643c_34360	COG2966	Psort location CytoplasmicMembrane, score
KAM643c_34380	COG0521	Mo-molybdopterin cofactor biosynthetic process
KAM643c_34420	COG2313	pseudouridylate synthase activity
KAM643c_34430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAM643c_34440	COG2146	nitrite reductase [NAD(P)H] activity
KAM643c_34440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM643c_34450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM643c_34450	COG2146	nitrite reductase [NAD(P)H] activity
KAM643c_34460	COG1116	anion transmembrane transporter activity
KAM643c_34470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KAM643c_34480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KAM643c_34480	COG1116	anion transmembrane transporter activity
KAM643c_34500	COG1648	precorrin-2 dehydrogenase activity
KAM643c_34500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM643c_34510	COG0243	molybdopterin cofactor binding
KAM643c_34560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KAM643c_34600	COG1073	alpha beta
KAM643c_34610	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KAM643c_34620	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAM643c_34640	COG4608	Belongs to the ABC transporter superfamily
KAM643c_34650	COG0444	Belongs to the ABC transporter superfamily
KAM643c_34670	COG4239	(ABC) transporter, permease
KAM643c_34680	COG4174	ABC transporter (Permease)
KAM643c_34700	COG4771	TonB-dependent receptor
KAM643c_34720	COG0811	peptide transport
KAM643c_34730	COG0811	peptide transport
KAM643c_34740	COG0848	biopolymer transport protein
KAM643c_34790	COG0675	Transposase, IS605 OrfB family
KAM643c_34820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM643c_34830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM643c_34840	COG0840	transmembrane signaling receptor activity
KAM643c_34860	COG1278	Cold shock
KAM643c_34870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KAM643c_34880	COG1162	GTPase activity
KAM643c_34890	COG0688	phosphatidylethanolamine metabolic process
KAM643c_34900	COG4628	conserved protein (DUF2132)
KAM643c_34940	COG5001	Diguanylate cyclase
KAM643c_34940	COG3300	MHYT domain
KAM643c_34950	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KAM643c_34990	COG3039	Transposase
KAM643c_35050	COG4974	Belongs to the 'phage' integrase family
KAM643c_35070	COG3385	transposase activity
KAM643c_35080	COG3447	MASE1 domain protein
KAM643c_35080	COG5001	Diguanylate cyclase
KAM643c_35080	COG5002	protein histidine kinase activity
KAM643c_35100	COG5001	Diguanylate cyclase
KAM643c_35100	COG5002	protein histidine kinase activity
KAM643c_35100	COG3447	MASE1 domain protein
KAM643c_35140	COG0582	viral genome integration into host DNA
KAM643c_35160	COG1132	(ABC) transporter
KAM643c_35180	COG2897	thiosulfate sulfurtransferase activity
KAM643c_35190	COG2066	Belongs to the glutaminase family
KAM643c_35200	COG3171	Protein conserved in bacteria
KAM643c_35210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KAM643c_35220	COG2234	aminopeptidase activity
KAM643c_35220	COG4935	Belongs to the peptidase S8 family
KAM643c_35230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAM643c_35240	COG2200	EAL domain
KAM643c_35250	COG1090	epimerase
KAM643c_35260	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KAM643c_35270	COG4181	ATPase activity
KAM643c_35290	COG0784	Response regulator, receiver
KAM643c_35290	COG0835	chemotaxis
KAM643c_35340	COG0675	Transposase, IS605 OrfB family
KAM643c_35360	COG0517	IMP dehydrogenase activity
KAM643c_35360	COG0516	GMP reductase activity
KAM643c_35370	COG0488	(ABC) transporter
KAM643c_35390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KAM643c_35460	COG3039	Transposase
KAM643c_35480	COG0789	Transcriptional regulator
KAM643c_35510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAM643c_35530	COG0668	transmembrane transport
KAM643c_35550	COG2731	YhcH YjgK YiaL family protein
KAM643c_35570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM643c_35580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM643c_35590	COG3227	Zinc metalloprotease (Elastase)
KAM643c_35600	COG0583	DNA-binding transcription factor activity
KAM643c_35610	COG0477	Major facilitator Superfamily
KAM643c_35630	COG0569	domain protein
KAM643c_35630	COG2985	domain, Protein
KAM643c_35640	COG1272	protein, Hemolysin III
KAM643c_35650	COG0076	glutamate decarboxylase activity
KAM643c_35660	COG2917	probably involved in intracellular septation
KAM643c_35670	COG2350	Protein conserved in bacteria
KAM643c_35690	COG1555	photosystem II stabilization
KAM643c_35700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KAM643c_35710	COG3104	oligopeptide transport
KAM643c_35720	COG0745	RESPONSE REGULATOR receiver
KAM643c_35790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_35810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAM643c_35820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KAM643c_35840	COG1280	lysine exporter protein (LysE YggA)
KAM643c_35900	COG2205	protein histidine kinase activity
KAM643c_35910	COG0745	RESPONSE REGULATOR receiver
KAM643c_35920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_35930	COG0577	efflux transmembrane transporter activity
KAM643c_35930	COG1136	(ABC) transporter
KAM643c_35950	COG0316	Belongs to the HesB IscA family
KAM643c_35970	COG0038	chloride channel
KAM643c_35980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KAM643c_36010	COG3385	transposase activity
KAM643c_36020	COG0671	phosphoesterase, PA-phosphatase related
KAM643c_36050	COG2076	Multidrug Resistance protein
KAM643c_36070	COG0346	lactoylglutathione lyase activity
KAM643c_36080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KAM643c_36090	COG1643	Atp-dependent helicase
KAM643c_36110	COG1489	DNA binding
KAM643c_36120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KAM643c_36130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAM643c_36150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KAM643c_36160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KAM643c_36170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KAM643c_36190	COG0842	Transport permease protein
KAM643c_36200	COG1131	(ABC) transporter
KAM643c_36230	COG0163	prenyltransferase activity
KAM643c_36240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAM643c_36250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KAM643c_36280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KAM643c_36310	COG1136	(ABC) transporter
KAM643c_36390	COG3385	transposase activity
KAM643c_36410	COG2801	Transposase and inactivated derivatives
KAM643c_36420	COG3415	Transposase
KAM643c_36420	COG2801	Transposase and inactivated derivatives
KAM643c_36450	COG0529	Catalyzes the synthesis of activated sulfate
KAM643c_36460	COG0471	metal ion transport
KAM643c_36460	COG3273	potassium ion transport
KAM643c_36470	COG2895	sulfate adenylyltransferase (ATP) activity
KAM643c_36480	COG0175	sulfate reduction
KAM643c_36490	COG1648	precorrin-2 dehydrogenase activity
KAM643c_36490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM643c_36500	COG0330	HflC and HflK could
KAM643c_36510	COG1585	Membrane protein implicated in regulation of membrane protease activity
KAM643c_36530	COG0673	inositol 2-dehydrogenase activity
KAM643c_36550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KAM643c_36560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAM643c_36570	COG3036	rescue of stalled ribosome
KAM643c_36600	COG0138	bifunctional purine biosynthesis protein purh
KAM643c_36660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAM643c_36670	COG0358	DNA primase activity
KAM643c_36680	COG1610	YqeY-like protein
KAM643c_36690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KAM643c_36700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KAM643c_36720	COG1388	LysM domain
KAM643c_36720	COG4942	peptidase
KAM643c_36730	COG1238	metal cluster binding
KAM643c_36740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAM643c_36750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KAM643c_36760	COG0585	pseudouridine synthase activity
KAM643c_36780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KAM643c_36790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KAM643c_36800	COG0148	phosphopyruvate hydratase activity
KAM643c_36810	COG0504	CTP synthase activity
KAM643c_36820	COG3956	TIGRFAM MazG family protein
KAM643c_36830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAM643c_36840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM643c_36860	COG4807	Protein conserved in bacteria
KAM643c_36870	COG3023	N-Acetylmuramoyl-L-alanine amidase
KAM643c_36880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KAM643c_36890	COG1381	Involved in DNA repair and RecF pathway recombination
KAM643c_36910	COG0571	ribonuclease III activity
KAM643c_36920	COG0681	Belongs to the peptidase S26 family
KAM643c_36930	COG0481	GTPase activity
KAM643c_36960	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KAM643c_36970	COG1595	DNA-templated transcription, initiation
KAM643c_36980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KAM643c_37000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KAM643c_37020	COG0583	DNA-binding transcription factor activity
KAM643c_37090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAM643c_37110	COG0126	phosphoglycerate kinase activity
KAM643c_37120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAM643c_37130	COG1940	carbohydrate kinase activity
KAM643c_37140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KAM643c_37160	COG4991	sh3 domain protein
KAM643c_37170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KAM643c_37200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KAM643c_37210	COG1028	Short-chain dehydrogenase reductase Sdr
KAM643c_37240	COG1505	serine-type exopeptidase activity
KAM643c_37250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KAM643c_37260	COG0765	amino acid transport
KAM643c_37270	COG0765	amino acid transport
KAM643c_37280	COG1126	abc transporter atp-binding protein
KAM643c_37290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAM643c_37300	COG3174	membrane
KAM643c_37310	COG0110	maltose O-acetyltransferase activity
KAM643c_37370	COG1942	4-Oxalocrotonate Tautomerase
KAM643c_37390	COG0583	DNA-binding transcription factor activity
KAM643c_37400	COG0165	Argininosuccinate lyase
KAM643c_37410	COG0137	argininosuccinate synthase activity
KAM643c_37430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAM643c_37440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KAM643c_37460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KAM643c_37470	COG5002	protein histidine kinase activity
KAM643c_37470	COG5001	Diguanylate cyclase
KAM643c_37470	COG3447	MASE1 domain protein
KAM643c_37480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KAM643c_37550	COG0583	DNA-binding transcription factor activity
KAM643c_37560	COG1380	Effector of murein hydrolase LrgA
KAM643c_37570	COG1346	cytolysis
KAM643c_37580	COG0460	homoserine dehydrogenase
KAM643c_37580	COG0527	aspartate kinase activity
KAM643c_37590	COG0626	cystathionine gamma-synthase activity
KAM643c_37620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAM643c_37630	COG0814	amino acid
KAM643c_37640	COG1218	3'(2'),5'-bisphosphate nucleotidase
KAM643c_37650	COG0494	nUDIX hydrolase
KAM643c_37660	COG1011	Hydrolase
KAM643c_37670	COG1902	pentaerythritol trinitrate reductase activity
KAM643c_37690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAM643c_37720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KAM643c_37740	COG3156	type II secretion system protein K
KAM643c_37750	COG4795	General secretion pathway protein
KAM643c_37760	COG2165	general secretion pathway protein
KAM643c_37780	COG2165	general secretion pathway protein
KAM643c_37790	COG1459	type II secretion system
KAM643c_37800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAM643c_37820	COG3031	protein transport across the cell outer membrane
KAM643c_37840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KAM643c_37850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KAM643c_37880	COG0456	acetyltransferase
KAM643c_37890	COG3133	Outer membrane lipoprotein
KAM643c_37900	COG3025	triphosphatase activity
KAM643c_37910	COG1392	Phosphate transport regulator
KAM643c_37920	COG0306	phosphate transporter
KAM643c_37930	COG0617	tRNA 3'-terminal CCA addition
KAM643c_37940	COG3409	Peptidoglycan-binding domain 1 protein
KAM643c_37940	COG3267	Type II secretory pathway component ExeA
KAM643c_37960	COG1194	a g-specific adenine glycosylase
KAM643c_37970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KAM643c_38000	COG3240	lipase activity
KAM643c_38020	COG3009	Protein conserved in bacteria
KAM643c_38030	COG3008	intermembrane lipid transfer
KAM643c_38030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAM643c_38040	COG2995	paraquat-inducible protein a
KAM643c_38060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAM643c_38070	COG5001	Diguanylate cyclase
KAM643c_38070	COG3706	GGDEF domain
KAM643c_38070	COG4251	negative regulation of phosphorylation
KAM643c_38070	COG2203	Gaf domain
KAM643c_38080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAM643c_38090	COG2813	Specifically methylates the guanine in position
KAM643c_38100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KAM643c_38110	COG0297	glycogen (starch) synthase activity
KAM643c_38140	COG1757	Na H antiporter
KAM643c_38150	COG0583	DNA-binding transcription factor activity
KAM643c_38160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KAM643c_38170	COG3842	ATPase activity
KAM643c_38180	COG1176	ABC-type spermidine putrescine transport system, permease component I
KAM643c_38190	COG1177	transmembrane transport
KAM643c_38200	COG1012	belongs to the aldehyde dehydrogenase family
KAM643c_38210	COG0109	protoheme IX farnesyltransferase activity
KAM643c_38270	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KAM643c_38290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAM643c_38290	COG1565	acr, cog1565
KAM643c_38300	COG1444	tRNA N-acetyltransferase activity
KAM643c_38340	COG1803	Methylglyoxal synthase
KAM643c_38370	COG0252	asparaginase activity
KAM643c_38410	COG1263	PTS System
KAM643c_38410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAM643c_38420	COG0366	Alpha amylase catalytic
KAM643c_38430	COG0110	maltose O-acetyltransferase activity
KAM643c_38440	COG1522	sequence-specific DNA binding
KAM643c_38510	COG3068	Protein conserved in bacteria
KAM643c_38530	COG0739	heme binding
KAM643c_38570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KAM643c_38580	COG1121	(ABC) transporter
KAM643c_38590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAM643c_38600	COG0583	DNA-binding transcription factor activity
KAM643c_38620	COG1573	uracil-dna glycosylase
KAM643c_38630	COG2962	Rard protein
KAM643c_38640	COG2827	Endonuclease containing a URI domain
KAM643c_38670	COG1842	Phage shock protein A
KAM643c_38680	COG0204	Acyl-transferase
KAM643c_38720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAM643c_38740	COG0484	heat shock protein binding
KAM643c_38830	COG3039	Transposase
KAM643c_38880	COG1289	transmembrane transporter activity
KAM643c_38890	COG1566	PFAM secretion protein HlyD family protein
KAM643c_38920	COG1051	belongs to the nudix hydrolase family
KAM643c_38930	COG3150	esterase
KAM643c_38950	COG3151	Protein conserved in bacteria
KAM643c_38960	COG0494	nUDIX hydrolase
KAM643c_38970	COG1538	Outer membrane efflux protein
KAM643c_38980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KAM643c_38980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KAM643c_38990	COG1560	Kdo2-lipid A biosynthetic process
KAM643c_39020	COG2771	luxR family
KAM643c_39030	COG3916	Acyl-homoserine-lactone synthase
KAM643c_39050	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KAM643c_39060	COG2213	PTS system mannitol-specific
KAM643c_39060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAM643c_39070	COG0246	Mannitol dehydrogenase
KAM643c_39080	COG3722	fumarate hydratase activity
KAM643c_39090	COG3263	regulation of cellular component size
KAM643c_39130	COG1671	Belongs to the UPF0178 family
KAM643c_39160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAM643c_39170	COG0513	Belongs to the DEAD box helicase family
KAM643c_39210	COG1575	Belongs to the MenA family. Type 1 subfamily
KAM643c_39220	COG1169	isochorismate synthase
KAM643c_39230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KAM643c_39240	COG0596	Alpha beta hydrolase
KAM643c_39250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KAM643c_39270	COG0318	PFAM AMP-dependent synthetase and ligase
KAM643c_39280	COG3291	Pkd domain containing protein
KAM643c_39290	COG2949	membrane
KAM643c_39300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KAM643c_39320	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KAM643c_39380	COG2873	o-acetylhomoserine
KAM643c_39400	COG1979	alcohol dehydrogenase
KAM643c_39430	COG4221	oxidoreductase activity
KAM643c_39470	COG1285	pathogenesis
KAM643c_39500	COG1368	sulfuric ester hydrolase activity
KAM643c_39510	COG1522	sequence-specific DNA binding
KAM643c_39530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KAM643c_39550	COG1546	Belongs to the CinA family
KAM643c_39550	COG1058	Belongs to the CinA family
KAM643c_39560	COG1988	membrane-bound metal-dependent
KAM643c_39590	COG0561	phosphatase activity
KAM643c_39600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KAM643c_39620	COG1011	Hydrolase
KAM643c_39650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KAM643c_39660	COG0019	diaminopimelate decarboxylase activity
KAM643c_39680	COG1965	Belongs to the frataxin family
KAM643c_39690	COG0400	carboxylic ester hydrolase activity
KAM643c_39700	COG3072	Adenylate cyclase
KAM643c_39710	COG0181	hydroxymethylbilane synthase activity
KAM643c_39730	COG2959	enzyme of heme biosynthesis
KAM643c_39740	COG3071	HemY protein
KAM643c_39760	COG0312	modulator of DNA gyrase
KAM643c_39770	COG3028	Belongs to the UPF0307 family
KAM643c_39790	COG2926	Belongs to the UPF0265 family
KAM643c_39810	COG1396	sequence-specific DNA binding
KAM643c_39820	COG3135	benzoate transporter
KAM643c_39880	COG3047	cAMP biosynthetic process
KAM643c_39900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KAM643c_39910	COG2197	response regulator
KAM643c_39980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAM643c_40040	COG1396	sequence-specific DNA binding
KAM643c_40100	COG1278	Cold shock
KAM643c_40160	COG3706	GGDEF domain
KAM643c_40170	COG0347	Belongs to the P(II) protein family
KAM643c_40180	COG0004	ammonium transporteR
KAM643c_40200	COG0346	lactoylglutathione lyase activity
KAM643c_40210	COG3385	transposase activity
KAM643c_40240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAM643c_40250	COG1074	ATP-dependent DNA helicase activity
KAM643c_40260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KAM643c_40270	COG2259	Doxx family
KAM643c_40280	COG1741	Belongs to the pirin family
KAM643c_40300	COG0583	DNA-binding transcription factor activity
KAM643c_40350	COG1175	transmembrane transport
KAM643c_40450	COG0456	acetyltransferase
KAM643c_40460	COG0753	catalase activity
KAM643c_40500	COG0494	nUDIX hydrolase
KAM643c_40510	COG0628	permease
KAM643c_40530	COG2957	Belongs to the agmatine deiminase family
KAM643c_40560	COG2957	Belongs to the agmatine deiminase family
KAM643c_40570	COG0583	DNA-binding transcription factor activity
KAM643c_40600	COG1461	Dihydroxyacetone kinase
KAM643c_40610	COG2376	Dihydroxyacetone kinase
KAM643c_40620	COG2252	PERMEase
KAM643c_40630	COG3335	DDE superfamily endonuclease
KAM643c_40640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KAM643c_40650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAM643c_40660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAM643c_40670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAM643c_40680	COG0049	tRNA binding
KAM643c_40690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KAM643c_40720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KAM643c_40730	COG0251	oxidation-reduction process
KAM643c_40740	COG2964	Protein conserved in bacteria
KAM643c_40750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KAM643c_40760	COG0085	RNA polymerase activity
KAM643c_40770	COG0222	ribosome binding
KAM643c_40780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KAM643c_40790	COG0081	regulation of translation
KAM643c_40800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KAM643c_40810	COG0250	Participates in transcription elongation, termination and antitermination
KAM643c_40830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAM643c_40860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KAM643c_40870	COG0569	domain protein
KAM643c_40880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM643c_40890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAM643c_40900	COG3005	denitrification pathway
KAM643c_40910	COG0243	molybdopterin cofactor binding
KAM643c_40980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KAM643c_41000	COG2204	response regulator
KAM643c_41020	COG2205	protein histidine kinase activity
KAM643c_41050	COG0516	GMP reductase activity
KAM643c_41050	COG0517	IMP dehydrogenase activity
KAM643c_41070	COG1522	sequence-specific DNA binding
KAM643c_41080	COG2502	aspartate--ammonia ligase
KAM643c_41110	COG0583	DNA-binding transcription factor activity
KAM643c_41120	COG0542	response to heat
KAM643c_41140	COG0564	pseudouridine synthase activity
KAM643c_41150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAM643c_41160	COG3681	Belongs to the UPF0597 family
KAM643c_41170	COG2964	Protein conserved in bacteria
KAM643c_41180	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KAM643c_41190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KAM643c_41200	COG1979	alcohol dehydrogenase
KAM643c_41210	COG2207	Transcriptional regulator
KAM643c_41220	COG3040	lipid binding
KAM643c_41260	COG0583	DNA-binding transcription factor activity
KAM643c_41290	COG0540	Belongs to the ATCase OTCase family
KAM643c_41300	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KAM643c_41310	COG1438	arginine binding
KAM643c_41320	COG1288	antiporter activity
KAM643c_41330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KAM643c_41420	COG3250	beta-galactosidase activity
KAM643c_41440	COG1609	Transcriptional regulator
KAM643c_41450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAM643c_41470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KAM643c_41480	COG2017	converts alpha-aldose to the beta-anomer
KAM643c_41490	COG0667	Aldo Keto reductase
KAM643c_41500	COG1968	undecaprenyl-diphosphatase activity
KAM643c_41510	COG3806	Anti-sigma factor
KAM643c_41520	COG1595	DNA-templated transcription, initiation
KAM643c_41560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KAM643c_41570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KAM643c_41580	COG0477	Major facilitator Superfamily
KAM643c_41610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAM643c_41620	COG1131	(ABC) transporter
KAM643c_41630	COG0842	Transport permease protein
KAM643c_41640	COG0842	Transport permease protein
KAM643c_41650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KAM643c_41670	COG2116	formate transmembrane transporter activity
KAM643c_41680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAM643c_41680	COG1648	precorrin-2 dehydrogenase activity
KAM643c_41690	COG2239	Acts as a magnesium transporter
KAM643c_41700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAM643c_41710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KAM643c_41730	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KAM643c_41750	COG0514	ATP-dependent DNA helicase (RecQ)
KAM643c_41760	COG2050	protein possibly involved in aromatic compounds catabolism
KAM643c_41780	COG2258	MOSC domain
KAM643c_41790	COG1177	transmembrane transport
KAM643c_41800	COG1176	ABC-type spermidine putrescine transport system, permease component I
KAM643c_41810	COG3842	ATPase activity
KAM643c_41850	COG0174	glutamine synthetase
KAM643c_41890	COG3045	CreA protein
KAM643c_41900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAM643c_41910	COG0443	Heat shock 70 kDa protein
KAM643c_41940	COG0366	Alpha amylase catalytic
KAM643c_41970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAM643c_41980	COG0745	RESPONSE REGULATOR receiver
KAM643c_41990	COG2205	protein histidine kinase activity
KAM643c_42010	COG0281	malic enzyme
KAM643c_42020	COG0702	epimerase
KAM643c_42030	COG0254	rRNA binding
KAM643c_42040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KAM643c_42090	COG0129	dihydroxy-acid dehydratase activity
KAM643c_42110	COG3978	acetolactate synthase activity
KAM643c_42130	COG0606	chelatase, subunit chli
KAM643c_42140	COG0204	Acyl-transferase
KAM643c_42150	COG0204	Acyl-transferase
KAM643c_42160	COG1683	Conserved Protein
KAM643c_42180	COG1335	isochorismatase
KAM643c_42200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAM643c_42210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KAM643c_42230	COG3084	Protein conserved in bacteria
KAM643c_42240	COG2203	Gaf domain
KAM643c_42240	COG3706	GGDEF domain
KAM643c_42240	COG4251	negative regulation of phosphorylation
KAM643c_42240	COG5001	Diguanylate cyclase
KAM643c_42270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KAM643c_42280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KAM643c_42290	COG1561	YicC-like family, N-terminal region
KAM643c_42310	COG1519	Transferase
KAM643c_42320	COG0859	PFAM glycosyl transferase family 9
KAM643c_42340	COG0463	Glycosyl transferase, family 2
KAM643c_42350	COG0859	PFAM glycosyl transferase family 9
KAM643c_42360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KAM643c_42370	COG2990	Protein conserved in bacteria
KAM643c_42380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KAM643c_42400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KAM643c_42410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KAM643c_42420	COG2003	Belongs to the UPF0758 family
KAM643c_42430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KAM643c_42440	COG0756	dUTP diphosphatase activity
KAM643c_42450	COG1309	transcriptional regulator
KAM643c_42460	COG0668	transmembrane transport
KAM643c_42480	COG0166	Belongs to the GPI family
KAM643c_42500	COG3335	DDE superfamily endonuclease
KAM643c_42510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KAM643c_42520	COG0583	DNA-binding transcription factor activity
KAM643c_42540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAM643c_42540	COG1042	CoA-binding domain protein
KAM643c_42540	COG0045	succinate-CoA ligase (ADP-forming) activity
KAM643c_42550	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KAM643c_42560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAM643c_42570	COG1739	Uncharacterized protein family UPF0029
KAM643c_42580	COG0006	proline dipeptidase activity
KAM643c_42590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAM643c_42600	COG1250	3-hydroxyacyl-CoA dehydrogenase
KAM643c_42600	COG1024	Enoyl-CoA hydratase
KAM643c_42610	COG0183	Belongs to the thiolase family
KAM643c_42660	COG0425	Belongs to the sulfur carrier protein TusA family
KAM643c_42670	COG0251	oxidation-reduction process
KAM643c_42680	COG2885	chlorophyll binding
KAM643c_42710	COG1335	isochorismatase
KAM643c_42720	COG2818	Glycosylase
KAM643c_42730	COG0752	glycyl-tRNA synthetase alpha subunit
KAM643c_42740	COG0751	glycine-tRNA ligase activity
KAM643c_42750	COG3039	Transposase
KAM643c_42780	COG2801	Transposase and inactivated derivatives
KAM643c_42800	COG2203	Gaf domain
KAM643c_42800	COG4251	negative regulation of phosphorylation
KAM643c_42800	COG5001	Diguanylate cyclase
KAM643c_42800	COG3706	GGDEF domain
KAM643c_42830	COG0814	amino acid
KAM643c_42840	COG0814	amino acid
KAM643c_42850	COG3033	Beta-eliminating lyase
KAM643c_42870	COG0348	domain, Protein
KAM643c_42890	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAM643c_42900	COG1773	rubredoxin
KAM643c_42900	COG0426	domain, Protein
KAM643c_42910	COG3604	Transcriptional regulator
KAM643c_42920	COG1609	Transcriptional regulator
KAM643c_43000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAM643c_43030	COG2960	long-chain fatty acid transporting porin activity
KAM643c_43050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KAM643c_43080	COG3118	belongs to the thioredoxin family
KAM643c_43090	COG0513	Belongs to the DEAD box helicase family
KAM643c_43100	COG0248	Ppx GppA phosphatase
KAM643c_43120	COG0742	ribosomal rna small subunit methyltransferase
KAM643c_43160	COG0084	hydrolase, TatD family'
KAM643c_43170	COG0805	protein transport
KAM643c_43180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM643c_43190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAM643c_43200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KAM643c_43210	COG3165	ubiquinone biosynthetic process from chorismate
KAM643c_43230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KAM643c_43240	COG0402	S-adenosylhomocysteine deaminase activity
KAM643c_43260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KAM643c_43270	COG0848	biopolymer transport protein
KAM643c_43280	COG0811	peptide transport
KAM643c_43290	COG0811	peptide transport
KAM643c_43310	COG2771	luxR family
KAM643c_43320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KAM643c_43330	COG1349	DNA-binding transcription factor activity
KAM643c_43340	COG0745	RESPONSE REGULATOR receiver
KAM643c_43350	COG2205	protein histidine kinase activity
KAM643c_43380	COG4452	Inner membrane protein CreD
KAM643c_43390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAM643c_43400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KAM643c_43410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KAM643c_43420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KAM643c_43430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KAM643c_43440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KAM643c_43450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAM643c_43470	COG0356	it plays a direct role in the translocation of protons across the membrane
KAM643c_43490	COG1475	DNA binding
KAM643c_43500	COG1192	Involved in chromosome partitioning
KAM643c_43510	COG0357	Ribosomal RNA small subunit methyltransferase G
KAM643c_43520	COG0445	tRNA wobble uridine modification
KAM643c_43530	COG0716	FMN binding
KAM643c_43540	COG4774	siderophore transport
KAM643c_43550	COG4615	Cyclic peptide transporter
KAM643c_43560	COG1120	ATPase activity
KAM643c_43570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KAM643c_43590	COG3550	peptidyl-serine autophosphorylation
KAM643c_43630	COG2801	Transposase and inactivated derivatives
KAM643c_43650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KAM643c_43660	COG0706	membrane insertase activity
KAM643c_43670	COG0594	ribonuclease P activity
KAM643c_43680	COG1126	abc transporter atp-binding protein
KAM643c_43970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_44240	COG0789	Transcriptional regulator
KAM643c_44340	COG5002	protein histidine kinase activity
KAM643c_44340	COG2176	DNA-directed DNA polymerase activity
KAM643c_44470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_44620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KAM643c_44650	COG1192	Involved in chromosome partitioning
KAM643c_44670	COG3335	DDE superfamily endonuclease
KAM643c_44780	COG0489	protein tyrosine kinase activity
KAM643c_44830	COG3039	Transposase
KAM643c_44910	COG3093	addiction module antidote protein HigA