locus-tag	class	description
GWC92_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWC92_00010	COG0592	DNA-directed DNA polymerase activity
GWC92_00020	COG0187	DNA topoisomerase II activity
GWC92_00025	COG2207	Transcriptional regulator
GWC92_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWC92_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GWC92_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GWC92_00045	COG3977	Valine--pyruvate aminotransferase
GWC92_00060	COG2814	Major facilitator Superfamily
GWC92_00065	COG0745	RESPONSE REGULATOR receiver
GWC92_00070	COG2205	protein histidine kinase activity
GWC92_00125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_00130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_00130	COG4191	Histidine kinase
GWC92_00135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_00145	COG1309	transcriptional regulator
GWC92_00175	COG0561	phosphatase activity
GWC92_00180	COG2267	carboxylic ester hydrolase activity
GWC92_00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWC92_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWC92_00195	COG1758	RNA polymerase activity
GWC92_00205	COG0859	PFAM glycosyl transferase family 9
GWC92_00210	COG3642	lipopolysaccharide core region biosynthetic process
GWC92_00250	COG0589	response to stress
GWC92_00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWC92_00260	COG3706	GGDEF domain
GWC92_00265	COG1528	Iron-storage protein
GWC92_00270	COG2081	HI0933 family
GWC92_00275	COG2223	nitrite transmembrane transporter activity
GWC92_00280	COG1280	lysine exporter protein (LysE YggA)
GWC92_00295	COG3188	usher protein
GWC92_00315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_00315	COG2205	protein histidine kinase activity
GWC92_00325	COG3275	phosphorelay sensor kinase activity
GWC92_00330	COG3279	Response regulator of the LytR AlgR family
GWC92_00335	COG2223	nitrite transmembrane transporter activity
GWC92_00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWC92_00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWC92_00390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWC92_00395	COG2166	iron-sulfur cluster assembly
GWC92_00400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWC92_00420	COG1063	alcohol dehydrogenase
GWC92_00425	COG0156	8-amino-7-oxononanoate synthase activity
GWC92_00435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWC92_00480	COG1609	Transcriptional regulator
GWC92_00500	COG1580	Controls the rotational direction of flagella during chemotaxis
GWC92_00505	COG3161	chorismate lyase activity
GWC92_00510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWC92_00515	COG2937	Belongs to the GPAT DAPAT family
GWC92_00520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWC92_00535	COG0534	Mate efflux family protein
GWC92_00540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWC92_00545	COG2205	protein histidine kinase activity
GWC92_00550	COG0745	RESPONSE REGULATOR receiver
GWC92_00560	COG1045	serine acetyltransferase
GWC92_00570	COG3074	FtsZ-dependent cytokinesis
GWC92_00575	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWC92_00580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_00580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_00585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWC92_00625	COG1609	Transcriptional regulator
GWC92_00630	COG3250	beta-galactosidase activity
GWC92_00635	COG2731	YhcH YjgK YiaL family protein
GWC92_00640	COG0531	amino acid
GWC92_00645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_00650	COG0531	amino acid
GWC92_00655	COG0385	Bile acid
GWC92_00660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWC92_00685	COG0583	DNA-binding transcription factor activity
GWC92_00690	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWC92_00695	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWC92_00700	COG3845	ABC transporter
GWC92_00705	COG1744	ABC transporter substrate-binding protein PnrA-like
GWC92_00710	COG0210	DNA helicase
GWC92_00720	COG1943	Transposase
GWC92_00725	COG0583	DNA-binding transcription factor activity
GWC92_00760	COG0583	DNA-binding transcription factor activity
GWC92_00775	COG1280	lysine exporter protein (LysE YggA)
GWC92_00785	COG2962	Rard protein
GWC92_00790	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_00795	COG1396	sequence-specific DNA binding
GWC92_00800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWC92_00810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWC92_00810	COG0519	Catalyzes the synthesis of GMP from XMP
GWC92_00820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_00840	COG1322	Protein conserved in bacteria
GWC92_00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_00850	COG0569	domain protein
GWC92_00855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_00855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_00860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWC92_00865	COG0242	peptide deformylase activity
GWC92_00875	COG0758	DNA mediated transformation
GWC92_00880	COG2922	Belongs to the Smg family
GWC92_00885	COG0551	DNA topoisomerase type I activity
GWC92_00890	COG0009	L-threonylcarbamoyladenylate synthase
GWC92_00895	COG0408	coproporphyrinogen oxidase activity
GWC92_00900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWC92_00905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWC92_00915	COG3078	GTPase activator activity
GWC92_00925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWC92_00930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWC92_00940	COG3852	Histidine kinase
GWC92_00950	COG0174	glutamine synthetase
GWC92_00955	COG1217	gtp-binding protein TYPA
GWC92_00960	COG1295	ribonuclease BN
GWC92_00965	COG1490	D-aminoacyl-tRNA deacylase activity
GWC92_00975	COG0456	acetyltransferase
GWC92_00985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWC92_00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWC92_00995	COG2610	gluconate transmembrane transporter activity
GWC92_01000	COG3265	gluconokinase activity
GWC92_01005	COG0129	dihydroxy-acid dehydratase activity
GWC92_01010	COG0800	Aldolase
GWC92_01025	COG1609	Transcriptional regulator
GWC92_01035	COG4942	peptidase
GWC92_01040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWC92_01045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_01050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWC92_01055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWC92_01060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWC92_01060	COG0316	Belongs to the HesB IscA family
GWC92_01065	COG1040	competence protein
GWC92_01070	COG0596	Alpha beta hydrolase
GWC92_01085	COG2183	response to ionizing radiation
GWC92_01090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWC92_01100	COG2205	protein histidine kinase activity
GWC92_01110	COG0051	transcription antitermination factor activity, RNA binding
GWC92_01115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWC92_01120	COG0088	Forms part of the polypeptide exit tunnel
GWC92_01125	COG0089	rRNA binding
GWC92_01130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWC92_01135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWC92_01140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWC92_01145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWC92_01150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWC92_01155	COG0255	Belongs to the universal ribosomal protein uL29 family
GWC92_01160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWC92_01165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWC92_01170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWC92_01175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWC92_01180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWC92_01185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWC92_01190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWC92_01195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWC92_01200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWC92_01205	COG1841	ribosomal large subunit assembly
GWC92_01210	COG0200	Binds to the 23S rRNA
GWC92_01215	COG0201	protein transport
GWC92_01220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWC92_01225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWC92_01230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWC92_01235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWC92_01240	COG0202	RNA polymerase activity
GWC92_01245	COG0203	ribosomal protein L17
GWC92_01300	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWC92_01305	COG0583	DNA-binding transcription factor activity
GWC92_01310	COG4221	oxidoreductase activity
GWC92_01325	COG1770	oligopeptidase
GWC92_01330	COG2358	TRAP transporter, solute receptor (TAXI family
GWC92_01345	COG3714	YhhN family
GWC92_01360	COG0583	DNA-binding transcription factor activity
GWC92_01370	COG1301	dicarboxylic acid transport
GWC92_01380	COG2095	MarC family integral membrane protein
GWC92_01390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_01400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWC92_01405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWC92_01430	COG0742	ribosomal rna small subunit methyltransferase
GWC92_01435	COG0552	protein localization to endoplasmic reticulum
GWC92_01440	COG2884	Cell division ATP-binding protein ftsE
GWC92_01445	COG2177	Part of the ABC transporter FtsEX involved in
GWC92_01455	COG0288	reversible hydration of carbon dioxide
GWC92_01460	COG2188	Transcriptional regulator
GWC92_01465	COG1228	amidohydrolase
GWC92_01470	COG0010	Belongs to the arginase family
GWC92_01475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWC92_01480	COG2986	histidine ammonia-lyase
GWC92_01485	COG0387	Pfam Sodium calcium exchanger
GWC92_01490	COG2200	EAL domain
GWC92_01540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWC92_01545	COG1459	type II secretion system
GWC92_01590	COG1077	Cell shape determining protein MreB Mrl
GWC92_01595	COG1792	Involved in formation and maintenance of cell shape
GWC92_01600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWC92_01605	COG0424	maF-like protein
GWC92_01610	COG1530	ribonuclease E activity
GWC92_01615	COG3164	Protein of unknown function
GWC92_01620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_01625	COG0312	modulator of DNA gyrase
GWC92_01640	COG0477	Major facilitator Superfamily
GWC92_01650	COG2321	neutral zinc metallopeptidase
GWC92_01685	COG0189	ligase activity
GWC92_01690	COG0642	Histidine kinase
GWC92_01695	COG0745	RESPONSE REGULATOR receiver
GWC92_01710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWC92_01715	COG0352	thiamine-phosphate diphosphorylase activity
GWC92_01720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWC92_01730	COG2022	thiamine diphosphate biosynthetic process
GWC92_01735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWC92_01755	COG0110	maltose O-acetyltransferase activity
GWC92_01770	COG3932	Exopolysaccharide synthesis, ExoD
GWC92_01785	COG1733	regulation of RNA biosynthetic process
GWC92_01810	COG2226	methyltransferase
GWC92_01820	COG1494	fructose-1,6-bisphosphatase
GWC92_01830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWC92_01835	COG5007	Belongs to the BolA IbaG family
GWC92_01845	COG2854	intermembrane phospholipid transfer
GWC92_01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWC92_01855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWC92_01860	COG1127	ABC transporter
GWC92_01865	COG0517	IMP dehydrogenase activity
GWC92_01865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWC92_01870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWC92_01880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWC92_01885	COG1137	ATPase activity
GWC92_01890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWC92_01900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_01905	COG1660	Displays ATPase and GTPase activities
GWC92_01910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_01930	COG3964	amidohydrolase
GWC92_01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWC92_01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWC92_01975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWC92_01980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWC92_01985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWC92_01990	COG0723	plastoquinol--plastocyanin reductase activity
GWC92_01995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWC92_02000	COG2857	Cytochrome c1
GWC92_02005	COG0625	glutathione transferase activity
GWC92_02010	COG2969	positive regulation of protein catabolic process
GWC92_02015	COG2823	Periplasmic or secreted lipoprotein
GWC92_02020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWC92_02025	COG0792	nuclease activity
GWC92_02030	COG3107	peptidoglycan biosynthetic process
GWC92_02035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWC92_02045	COG2001	Belongs to the MraZ family
GWC92_02050	COG0275	rRNA processing
GWC92_02055	COG3116	cell division
GWC92_02060	COG0768	penicillin binding
GWC92_02065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWC92_02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWC92_02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWC92_02080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWC92_02085	COG0772	Belongs to the SEDS family
GWC92_02090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWC92_02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWC92_02100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWC92_02105	COG0849	cell division
GWC92_02110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWC92_02115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWC92_02125	COG0653	protein targeting
GWC92_02135	COG0494	nUDIX hydrolase
GWC92_02140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWC92_02145	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWC92_02160	COG1459	type II secretion system
GWC92_02165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWC92_02190	COG2186	Transcriptional regulator
GWC92_02195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWC92_02200	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWC92_02205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_02215	COG0840	transmembrane signaling receptor activity
GWC92_02220	COG0840	transmembrane signaling receptor activity
GWC92_02225	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWC92_02230	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWC92_02235	COG2200	EAL domain
GWC92_02245	COG1280	lysine exporter protein (LysE YggA)
GWC92_02255	COG0523	cobalamin synthesis protein
GWC92_02260	COG0477	Major facilitator Superfamily
GWC92_02275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWC92_02280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWC92_02325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWC92_02355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWC92_02360	COG0732	type I restriction modification DNA specificity domain
GWC92_02365	COG1401	restriction endodeoxyribonuclease activity
GWC92_02365	COG1401	restriction endodeoxyribonuclease activity
GWC92_02375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWC92_02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_02425	COG1546	Belongs to the CinA family
GWC92_02430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWC92_02435	COG2137	regulation of response to DNA damage stimulus
GWC92_02440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWC92_02445	COG0527	aspartate kinase activity
GWC92_02450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWC92_02485	COG1686	Belongs to the peptidase S11 family
GWC92_02490	COG0586	Pfam SNARE associated Golgi protein
GWC92_02495	COG1253	flavin adenine dinucleotide binding
GWC92_02500	COG0525	valine-tRNA ligase activity
GWC92_02505	COG2927	DNA polymerase III (CHI subunit)
GWC92_02510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_02515	COG0795	lipopolysaccharide-transporting ATPase activity
GWC92_02520	COG0795	lipopolysaccharide-transporting ATPase activity
GWC92_02540	COG0004	ammonium transporteR
GWC92_02545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_02555	COG2165	general secretion pathway protein
GWC92_02560	COG0084	hydrolase, TatD family'
GWC92_02565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_02575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWC92_02580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWC92_02585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWC92_02590	COG0813	purine-nucleoside phosphorylase activity
GWC92_02595	COG5002	protein histidine kinase activity
GWC92_02595	COG5001	Diguanylate cyclase
GWC92_02595	COG3447	MASE1 domain protein
GWC92_02605	COG0560	Phosphoserine phosphatase
GWC92_02620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWC92_02630	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWC92_02635	COG0776	regulation of translation
GWC92_02650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWC92_02655	COG0735	belongs to the Fur family
GWC92_02675	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWC92_02680	COG0513	Belongs to the DEAD box helicase family
GWC92_02685	COG3022	response to hydroperoxide
GWC92_02700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWC92_02705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWC92_02710	COG0762	integral membrane protein
GWC92_02715	COG1872	DUF167
GWC92_02735	COG3112	Uncharacterised protein family (UPF0231)
GWC92_02740	COG3835	regulator
GWC92_02745	COG2610	gluconate transmembrane transporter activity
GWC92_02750	COG1929	Belongs to the glycerate kinase type-1 family
GWC92_02765	COG0583	DNA-binding transcription factor activity
GWC92_02770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_02785	COG0347	Belongs to the P(II) protein family
GWC92_02790	COG1840	ABC-type Fe3 transport system, periplasmic component
GWC92_02800	COG3842	ATPase activity
GWC92_02805	COG2837	iron assimilation
GWC92_02810	COG1438	arginine binding
GWC92_02815	COG1126	abc transporter atp-binding protein
GWC92_02820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_02825	COG4215	(ABC) transporter
GWC92_02830	COG4160	amino acid transport
GWC92_02835	COG0039	L-malate dehydrogenase activity
GWC92_02840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWC92_02845	COG1017	nitric oxide dioxygenase activity
GWC92_02845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_02855	COG4536	flavin adenine dinucleotide binding
GWC92_02860	COG4137	Cytochrome C assembly protein
GWC92_02865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWC92_02870	COG0228	four-way junction DNA binding
GWC92_02875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWC92_02880	COG0336	Belongs to the RNA methyltransferase TrmD family
GWC92_02885	COG0335	large ribosomal subunit rRNA binding
GWC92_02900	COG1051	belongs to the nudix hydrolase family
GWC92_02910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWC92_02915	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWC92_02920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWC92_02930	COG0583	DNA-binding transcription factor activity
GWC92_02935	COG0640	Transcriptional regulator
GWC92_02940	COG0268	Binds directly to 16S ribosomal RNA
GWC92_02945	COG0728	peptidoglycan biosynthetic process
GWC92_02950	COG0196	riboflavin kinase activity
GWC92_02955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWC92_02960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWC92_02965	COG1047	Peptidyl-prolyl cis-trans
GWC92_02970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWC92_03020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWC92_03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_03035	COG1854	S-ribosylhomocysteine lyase activity
GWC92_03040	COG3706	GGDEF domain
GWC92_03045	COG0557	exoribonuclease II activity
GWC92_03050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWC92_03060	COG2153	protein acetylation
GWC92_03070	COG1914	H( )-stimulated, divalent metal cation uptake system
GWC92_03075	COG0360	Binds together with S18 to 16S ribosomal RNA
GWC92_03080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWC92_03085	COG0359	binds to the 23S rRNA
GWC92_03125	COG1238	metal cluster binding
GWC92_03130	COG0612	Peptidase, M16
GWC92_03135	COG2918	glutathione biosynthetic process
GWC92_03140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWC92_03145	COG1027	Aspartate ammonia-lyase
GWC92_03150	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWC92_03155	COG0534	Mate efflux family protein
GWC92_03160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWC92_03165	COG0459	protein refolding
GWC92_03185	COG0564	pseudouridine synthase activity
GWC92_03190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWC92_03225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWC92_03240	COG4208	sulfate ABC transporter
GWC92_03245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWC92_03250	COG0583	DNA-binding transcription factor activity
GWC92_03255	COG3397	chitin binding
GWC92_03285	COG1328	CTP reductase activity
GWC92_03290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWC92_03305	COG1448	Aminotransferase
GWC92_03330	COG1215	transferase activity, transferring glycosyl groups
GWC92_03340	COG0457	Tetratricopeptide repeat
GWC92_03340	COG3118	belongs to the thioredoxin family
GWC92_03345	COG0457	Tetratricopeptide repeat
GWC92_03345	COG3118	belongs to the thioredoxin family
GWC92_03385	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GWC92_03390	COG0513	Belongs to the DEAD box helicase family
GWC92_03395	COG0840	transmembrane signaling receptor activity
GWC92_03405	COG4166	transmembrane transport
GWC92_03420	COG1024	Enoyl-CoA hydratase
GWC92_03435	COG4221	oxidoreductase activity
GWC92_03440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_03445	COG0442	prolyl-tRNA aminoacylation
GWC92_03450	COG0840	transmembrane signaling receptor activity
GWC92_03455	COG0632	four-way junction helicase activity
GWC92_03460	COG2255	four-way junction helicase activity
GWC92_03470	COG1271	oxidase subunit
GWC92_03475	COG1294	oxidase, subunit
GWC92_03480	COG4890	Cyd operon protein YbgT
GWC92_03485	COG3790	cyd operon protein YbgE
GWC92_03490	COG0824	Thioesterase
GWC92_03495	COG0811	peptide transport
GWC92_03510	COG0823	Involved in the tonB-independent uptake of proteins
GWC92_03515	COG2885	chlorophyll binding
GWC92_03520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWC92_03595	COG0840	transmembrane signaling receptor activity
GWC92_03600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWC92_03610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWC92_03615	COG1640	4-alpha-glucanotransferase
GWC92_03620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWC92_03650	COG2130	NADP-dependent
GWC92_03655	COG1846	Transcriptional regulator
GWC92_03685	COG0561	phosphatase activity
GWC92_03700	COG0733	neurotransmitter:sodium symporter activity
GWC92_03705	COG0733	neurotransmitter:sodium symporter activity
GWC92_03720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_03735	COG1794	racemase activity, acting on amino acids and derivatives
GWC92_03745	COG1022	Amp-dependent synthetase and ligase
GWC92_03755	COG0456	acetyltransferase
GWC92_03805	COG1917	Cupin 2, conserved barrel domain protein
GWC92_03805	COG2207	Transcriptional regulator
GWC92_03815	COG0513	Belongs to the DEAD box helicase family
GWC92_03855	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWC92_03865	COG0577	efflux transmembrane transporter activity
GWC92_03865	COG1136	(ABC) transporter
GWC92_03870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_03875	COG0745	RESPONSE REGULATOR receiver
GWC92_03880	COG2205	protein histidine kinase activity
GWC92_03935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_03945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWC92_03950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWC92_03955	COG1178	ABC-type Fe3 transport system permease component
GWC92_03960	COG4143	(ABC) transporter
GWC92_03975	COG0066	3-isopropylmalate dehydratase activity
GWC92_03980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWC92_03985	COG0473	3-isopropylmalate dehydrogenase activity
GWC92_03990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWC92_04000	COG0671	phosphoesterase, PA-phosphatase related
GWC92_04015	COG0028	Belongs to the TPP enzyme family
GWC92_04020	COG0440	acetolactate synthase activity
GWC92_04025	COG0280	phosphate acetyltransferase
GWC92_04025	COG0857	belongs to the CobB CobQ family
GWC92_04030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWC92_04035	COG3092	negative regulation of chromosome organization
GWC92_04040	COG3013	Belongs to the UPF0304 family
GWC92_04045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWC92_04050	COG2716	regulation of RNA biosynthetic process
GWC92_04055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWC92_04060	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWC92_04065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWC92_04080	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWC92_04100	COG0784	Response regulator, receiver
GWC92_04100	COG5002	protein histidine kinase activity
GWC92_04100	COG2198	Histidine kinase
GWC92_04105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GWC92_04135	COG1464	Belongs to the NlpA lipoprotein family
GWC92_04140	COG2011	ABC-type metal ion transport system permease component
GWC92_04145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWC92_04165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWC92_04165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWC92_04170	COG0802	atpase or kinase
GWC92_04180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWC92_04185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWC92_04190	COG1923	regulation of RNA biosynthetic process
GWC92_04195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWC92_04200	COG0330	HflC and HflK could
GWC92_04205	COG0330	HflC and HflK could
GWC92_04210	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWC92_04215	COG0142	geranyltranstransferase activity
GWC92_04220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWC92_04225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWC92_04230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWC92_04235	COG3314	Sporulation integral membrane protein YlbJ
GWC92_04240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_04245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWC92_04255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWC92_04260	COG2967	ApaG domain
GWC92_04265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWC92_04270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWC92_04280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWC92_04285	COG3178	'Phosphotransferase
GWC92_04290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWC92_04295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWC92_04300	COG2252	PERMEase
GWC92_04310	COG0488	(ABC) transporter
GWC92_04315	COG0582	viral genome integration into host DNA
GWC92_04380	COG1846	Transcriptional regulator
GWC92_04465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWC92_04470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWC92_04475	COG2135	peptidase activity
GWC92_04525	COG4626	Terminase
GWC92_04525	COG1802	Transcriptional regulator
GWC92_04540	COG0616	signal peptide processing
GWC92_04650	COG0741	lytic transglycosylase activity
GWC92_04655	COG0463	Glycosyl transferase, family 2
GWC92_04665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWC92_04690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_04700	COG3721	Heme iron utilization protein
GWC92_04705	COG0748	coenzyme F420 binding
GWC92_04730	COG2814	Major facilitator Superfamily
GWC92_04735	COG2205	protein histidine kinase activity
GWC92_04735	COG2202	Pas domain
GWC92_04745	COG2226	methyltransferase
GWC92_04755	COG1765	OsmC-like protein
GWC92_04770	COG3954	Phosphoribulokinase
GWC92_04775	COG3089	Belongs to the UPF0270 family
GWC92_04780	COG2203	Gaf domain
GWC92_04780	COG5001	Diguanylate cyclase
GWC92_04780	COG4251	negative regulation of phosphorylation
GWC92_04780	COG3706	GGDEF domain
GWC92_04785	COG0429	hydrolase of the alpha beta-hydrolase fold
GWC92_04790	COG0784	Response regulator, receiver
GWC92_04790	COG0835	chemotaxis
GWC92_04800	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWC92_04805	COG1047	Peptidyl-prolyl cis-trans
GWC92_04810	COG2900	Belongs to the SlyX family
GWC92_04820	COG0545	Peptidyl-prolyl cis-trans isomerase
GWC92_04825	COG2204	response regulator
GWC92_04845	COG0737	Belongs to the 5'-nucleotidase family
GWC92_04860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_04865	COG0506	proline dehydrogenase activity
GWC92_04865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWC92_04865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWC92_04875	COG0114	fumarate hydratase activity
GWC92_04885	COG1566	PFAM secretion protein HlyD family protein
GWC92_04965	COG1280	lysine exporter protein (LysE YggA)
GWC92_04970	COG0826	peptidase U32
GWC92_04980	COG3813	Protein conserved in bacteria
GWC92_05000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWC92_05025	COG0300	oxidoreductase activity
GWC92_05035	COG0840	transmembrane signaling receptor activity
GWC92_05045	COG2610	gluconate transmembrane transporter activity
GWC92_05050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWC92_05055	COG3622	Belongs to the hyi family
GWC92_05060	COG0235	Class ii aldolase
GWC92_05070	COG2084	Dehydrogenase
GWC92_05075	COG1349	DNA-binding transcription factor activity
GWC92_05085	COG2133	pyrroloquinoline quinone binding
GWC92_05125	COG4397	Mu-like prophage major head subunit gpT
GWC92_05160	COG0077	Prephenate dehydratase
GWC92_05160	COG1605	Chorismate mutase
GWC92_05185	COG3272	Protein of unknown function (DUF1722)
GWC92_05190	COG0789	Transcriptional regulator
GWC92_05195	COG0415	Belongs to the DNA photolyase family
GWC92_05205	COG4221	oxidoreductase activity
GWC92_05220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWC92_05245	COG0783	Belongs to the Dps family
GWC92_05250	COG1151	hydroxylamine reductase activity
GWC92_05255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_05260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_05275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_05280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_05290	COG5000	phosphorelay sensor kinase activity
GWC92_05290	COG5002	protein histidine kinase activity
GWC92_05300	COG0659	secondary active sulfate transmembrane transporter activity
GWC92_05310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWC92_05315	COG1666	GTP binding
GWC92_05325	COG2211	Major facilitator Superfamily
GWC92_05335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWC92_05345	COG2813	Specifically methylates the guanine in position
GWC92_05350	COG0271	Belongs to the BolA IbaG family
GWC92_05355	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_05360	COG1805	sodium ion transport
GWC92_05365	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_05370	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_05375	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_05380	COG2871	sodium ion transport
GWC92_05385	COG1477	protein flavinylation
GWC92_05400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWC92_05405	COG0840	transmembrane signaling receptor activity
GWC92_05410	COG0583	DNA-binding transcription factor activity
GWC92_05425	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWC92_05435	COG0473	3-isopropylmalate dehydrogenase activity
GWC92_05440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_05445	COG1611	Belongs to the LOG family
GWC92_05460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWC92_05460	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWC92_05470	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWC92_05495	COG3098	single-species biofilm formation
GWC92_05500	COG0564	pseudouridine synthase activity
GWC92_05515	COG4580	involved in the transport of maltose and maltodextrins
GWC92_05525	COG1263	PTS System
GWC92_05525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_05535	COG2171	N-acyltransferase activity
GWC92_05540	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWC92_05545	COG0024	Methionine aminopeptidase
GWC92_05550	COG0052	Belongs to the universal ribosomal protein uS2 family
GWC92_05555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWC92_05560	COG0528	UMP kinase activity
GWC92_05565	COG0233	cytoplasmic translational termination
GWC92_05570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWC92_05575	COG0575	Belongs to the CDS family
GWC92_05580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWC92_05585	COG0750	zinc metalloprotease
GWC92_05600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_05605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWC92_05610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_05615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_05620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWC92_05625	COG0587	DNA-directed DNA polymerase activity
GWC92_05630	COG0825	malonyl-CoA metabolic process
GWC92_05645	COG0814	amino acid
GWC92_05650	COG0531	amino acid
GWC92_05660	COG0488	(ABC) transporter
GWC92_05670	COG3590	peptidase
GWC92_05675	COG0037	tRNA processing
GWC92_05680	COG3706	GGDEF domain
GWC92_05725	COG0366	Alpha amylase catalytic
GWC92_05740	COG0463	Glycosyl transferase, family 2
GWC92_05755	COG2989	Protein conserved in bacteria
GWC92_05760	COG3108	Peptidase M15
GWC92_05770	COG2860	membrane
GWC92_05780	COG1196	nuclear chromosome segregation
GWC92_05785	COG3115	cell septum assembly
GWC92_05790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWC92_05800	COG1328	CTP reductase activity
GWC92_05805	COG0602	queuosine metabolic process
GWC92_05830	COG1566	PFAM secretion protein HlyD family protein
GWC92_05840	COG3290	protein histidine kinase activity
GWC92_05855	COG0667	Aldo Keto reductase
GWC92_05865	COG0697	spore germination
GWC92_05880	COG3284	Transcriptional regulator
GWC92_05885	COG3706	GGDEF domain
GWC92_05890	COG0346	lactoylglutathione lyase activity
GWC92_05895	COG0745	RESPONSE REGULATOR receiver
GWC92_05900	COG5002	protein histidine kinase activity
GWC92_05910	COG4783	chaperone-mediated protein folding
GWC92_05930	COG0545	Peptidyl-prolyl cis-trans isomerase
GWC92_05935	COG1131	(ABC) transporter
GWC92_05940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWC92_05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_05955	COG4597	amino acid ABC transporter
GWC92_05960	COG0765	amino acid transport
GWC92_05965	COG1126	abc transporter atp-binding protein
GWC92_05975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWC92_05980	COG0678	peroxiredoxin activity
GWC92_05990	COG0019	diaminopimelate decarboxylase activity
GWC92_05995	COG1115	amino acid carrier protein
GWC92_06000	COG0095	Lipoate-protein ligase
GWC92_06005	COG2233	PERMEase
GWC92_06025	COG2207	Transcriptional regulator
GWC92_06030	COG0281	malic enzyme
GWC92_06060	COG0733	neurotransmitter:sodium symporter activity
GWC92_06065	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWC92_06070	COG3706	GGDEF domain
GWC92_06080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_06085	COG1032	radical SAM domain protein
GWC92_06090	COG3903	Transcriptional regulator
GWC92_06090	COG2319	Wd-40 repeat
GWC92_06110	COG0673	inositol 2-dehydrogenase activity
GWC92_06115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWC92_06120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWC92_06150	COG0741	lytic transglycosylase activity
GWC92_06150	COG1196	nuclear chromosome segregation
GWC92_06150	COG0739	heme binding
GWC92_06175	COG0788	formyltetrahydrofolate deformylase activity
GWC92_06180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWC92_06190	COG3118	belongs to the thioredoxin family
GWC92_06200	COG0791	NLP P60 protein
GWC92_06205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWC92_06220	COG1376	ErfK ybiS ycfS ynhG family protein
GWC92_06220	COG1388	LysM domain
GWC92_06245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWC92_06285	COG1203	CRISPR-associated helicase, Cas3
GWC92_06290	COG1518	maintenance of DNA repeat elements
GWC92_06325	COG2003	Belongs to the UPF0758 family
GWC92_06370	COG3311	Transcriptional regulator
GWC92_06385	COG0582	viral genome integration into host DNA
GWC92_06390	COG2205	protein histidine kinase activity
GWC92_06390	COG0784	Response regulator, receiver
GWC92_06415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_06415	COG2205	protein histidine kinase activity
GWC92_06420	COG3384	dioxygenase
GWC92_06430	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWC92_06440	COG0531	amino acid
GWC92_06445	COG0531	amino acid
GWC92_06455	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_06460	COG1917	Cupin 2, conserved barrel domain protein
GWC92_06460	COG1396	sequence-specific DNA binding
GWC92_06465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_06510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWC92_06510	COG4651	solute:proton antiporter activity
GWC92_06525	COG2974	May be involved in recombination
GWC92_06530	COG1247	-acetyltransferase
GWC92_06535	COG0420	3'-5' exonuclease activity
GWC92_06545	COG3038	cytochrome b561
GWC92_06550	COG2190	(PTS) system
GWC92_06560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_06565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWC92_06570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWC92_06585	COG1720	tRNA m6t6A37 methyltransferase activity
GWC92_06605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWC92_06610	COG4988	ABC transporter
GWC92_06625	COG0745	RESPONSE REGULATOR receiver
GWC92_06635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWC92_06650	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWC92_06655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWC92_06670	COG0083	homoserine kinase activity
GWC92_06675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWC92_06705	COG1943	Transposase
GWC92_06715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWC92_06725	COG3220	belongs to the UPF0276 family
GWC92_06755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_06760	COG1289	transmembrane transporter activity
GWC92_06765	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWC92_06770	COG0746	molybdenum cofactor guanylyltransferase activity
GWC92_06775	COG0281	malic enzyme
GWC92_06805	COG1196	nuclear chromosome segregation
GWC92_06805	COG3264	Mechanosensitive ion channel
GWC92_06815	COG2850	peptidyl-arginine hydroxylation
GWC92_06820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWC92_06825	COG2915	High frequency lysogenization protein hflD homolog
GWC92_06830	COG0482	sulfurtransferase activity
GWC92_06840	COG1187	pseudouridine synthase activity
GWC92_06845	COG0456	acetyltransferase
GWC92_06875	COG0538	isocitrate dehydrogenase activity
GWC92_06885	COG3048	D-serine ammonia-lyase activity
GWC92_06890	COG0583	DNA-binding transcription factor activity
GWC92_06895	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWC92_06900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_06905	COG2375	cellular response to nickel ion
GWC92_06910	COG1538	Outer membrane efflux protein
GWC92_06915	COG0577	efflux transmembrane transporter activity
GWC92_06915	COG1136	(ABC) transporter
GWC92_06920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_06930	COG0497	DNA recombination
GWC92_06935	COG3706	GGDEF domain
GWC92_06940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWC92_06945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWC92_06950	COG0443	Heat shock 70 kDa protein
GWC92_06955	COG0484	heat shock protein binding
GWC92_06985	COG1285	pathogenesis
GWC92_06995	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_07005	COG0640	Transcriptional regulator
GWC92_07015	COG2391	methyltransferase activity
GWC92_07035	COG0095	Lipoate-protein ligase
GWC92_07050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_07055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_07065	COG0708	Exodeoxyribonuclease III
GWC92_07075	COG0745	RESPONSE REGULATOR receiver
GWC92_07090	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWC92_07105	COG1846	Transcriptional regulator
GWC92_07125	COG0583	DNA-binding transcription factor activity
GWC92_07130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWC92_07135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWC92_07140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWC92_07145	COG1845	cytochrome c oxidase, subunit III
GWC92_07150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWC92_07155	COG0109	protoheme IX farnesyltransferase activity
GWC92_07165	COG2814	Major facilitator Superfamily
GWC92_07170	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWC92_07180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWC92_07185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWC92_07190	COG4521	taurine ABC transporter
GWC92_07220	COG1988	membrane-bound metal-dependent
GWC92_07235	COG0159	tryptophan synthase activity
GWC92_07240	COG0133	tryptophan synthase activity
GWC92_07245	COG0135	phosphoribosylanthranilate isomerase activity
GWC92_07245	COG0134	indole-3-glycerol-phosphate synthase activity
GWC92_07250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWC92_07255	COG0512	Glutamine amidotransferase of anthranilate synthase
GWC92_07255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWC92_07260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWC92_07265	COG0613	PHP domain protein
GWC92_07270	COG0009	L-threonylcarbamoyladenylate synthase
GWC92_07280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWC92_07290	COG1946	Acyl-CoA thioesterase
GWC92_07305	COG1309	transcriptional regulator
GWC92_07310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_07315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_07370	COG2003	Belongs to the UPF0758 family
GWC92_07385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWC92_07400	COG0583	DNA-binding transcription factor activity
GWC92_07420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWC92_07430	COG1960	acyl-CoA dehydrogenase activity
GWC92_07435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_07445	COG0469	pyruvate kinase activity
GWC92_07450	COG1737	Transcriptional regulator
GWC92_07455	COG0837	glucose binding
GWC92_07475	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWC92_07490	COG2801	Transposase and inactivated derivatives
GWC92_07515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWC92_07595	COG1216	Glycosyl transferase, family 2
GWC92_07615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWC92_07620	COG0489	protein tyrosine kinase activity
GWC92_07620	COG3206	protein involved in exopolysaccharide biosynthesis
GWC92_07640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_07650	COG3132	Protein of unknown function, DUF480
GWC92_07675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWC92_07690	COG1278	Cold shock
GWC92_07715	COG4166	transmembrane transport
GWC92_07720	COG0697	spore germination
GWC92_07730	COG0675	Transposase, IS605 OrfB family
GWC92_07735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_07750	COG4166	transmembrane transport
GWC92_07755	COG0622	Phosphoesterase
GWC92_07770	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GWC92_07775	COG0784	Response regulator, receiver
GWC92_07775	COG0835	chemotaxis
GWC92_07780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWC92_07785	COG1815	bacterial-type flagellum-dependent cell motility
GWC92_07800	COG1749	Flagellar hook protein flgE
GWC92_07815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWC92_07820	COG1706	bacterial-type flagellum-dependent cell motility
GWC92_07825	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWC92_07825	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWC92_07840	COG2239	Acts as a magnesium transporter
GWC92_07850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWC92_07855	COG2716	regulation of RNA biosynthetic process
GWC92_07880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWC92_07885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWC92_07890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWC92_07895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWC92_07915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWC92_07925	COG0590	tRNA wobble adenosine to inosine editing
GWC92_07930	COG0573	inorganic phosphate transmembrane transporter activity
GWC92_07935	COG0581	inorganic phosphate transmembrane transporter activity
GWC92_07940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWC92_07945	COG0704	Plays a role in the regulation of phosphate uptake
GWC92_07950	COG1253	flavin adenine dinucleotide binding
GWC92_07965	COG0531	amino acid
GWC92_07980	COG1126	abc transporter atp-binding protein
GWC92_07985	COG0765	amino acid transport
GWC92_07990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_07995	COG3706	GGDEF domain
GWC92_08000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWC92_08020	COG1785	Belongs to the alkaline phosphatase family
GWC92_08025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWC92_08030	COG0477	Major facilitator Superfamily
GWC92_08035	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWC92_08045	COG1199	ATP-dependent helicase activity
GWC92_08060	COG1448	Aminotransferase
GWC92_08065	COG0433	COG0433 Predicted ATPase
GWC92_08080	COG2333	competence protein COMEC
GWC92_08080	COG0658	competence protein
GWC92_08085	COG1132	(ABC) transporter
GWC92_08090	COG1663	tetraacyldisaccharide 4'-kinase activity
GWC92_08095	COG2835	tetraacyldisaccharide 4'-kinase activity
GWC92_08100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWC92_08105	COG2197	response regulator
GWC92_08110	COG0322	excinuclease ABC activity
GWC92_08135	COG0583	DNA-binding transcription factor activity
GWC92_08150	COG0604	alcohol dehydrogenase
GWC92_08155	COG1309	transcriptional regulator
GWC92_08160	COG2261	transglycosylase associated protein
GWC92_08165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_08175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWC92_08180	COG0215	cysteine-tRNA ligase activity
GWC92_08200	COG2199	diguanylate cyclase activity
GWC92_08200	COG2203	Gaf domain
GWC92_08235	COG2119	membrane
GWC92_08240	COG0023	Translation Initiation Factor
GWC92_08250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWC92_08275	COG4139	cobalamin transport
GWC92_08280	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWC92_08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_08295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWC92_08300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWC92_08305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWC92_08310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWC92_08320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWC92_08325	COG0505	Belongs to the CarA family
GWC92_08330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWC92_08335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWC92_08340	COG3706	GGDEF domain
GWC92_08370	COG0513	Belongs to the DEAD box helicase family
GWC92_08380	COG4104	PAAR repeat-containing protein
GWC92_08405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_08410	COG0765	amino acid transport
GWC92_08415	COG1126	abc transporter atp-binding protein
GWC92_08420	COG0493	'glutamate synthase
GWC92_08425	COG0070	glutamate synthase
GWC92_08425	COG0067	glutamate synthase
GWC92_08425	COG0069	glutamate synthase activity
GWC92_08430	COG1242	4 iron, 4 sulfur cluster binding
GWC92_08475	COG1113	amino acid transport
GWC92_08485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWC92_08490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWC92_08490	COG0574	Belongs to the PEP-utilizing enzyme family
GWC92_08495	COG1119	ATPase activity
GWC92_08515	COG1464	Belongs to the NlpA lipoprotein family
GWC92_08525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWC92_08530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWC92_08540	COG0101	tRNA pseudouridine synthase activity
GWC92_08545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWC92_08550	COG0285	dihydrofolate synthase activity
GWC92_08555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWC92_08560	COG2920	part of a sulfur-relay system
GWC92_08565	COG1289	transmembrane transporter activity
GWC92_08570	COG0670	Belongs to the BI1 family
GWC92_08610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWC92_08615	COG0840	transmembrane signaling receptor activity
GWC92_08620	COG5001	Diguanylate cyclase
GWC92_08625	COG0564	pseudouridine synthase activity
GWC92_08640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWC92_08650	COG0625	glutathione transferase activity
GWC92_08665	COG0367	asparagine synthase
GWC92_08675	COG0647	UMP catabolic process
GWC92_08680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWC92_08685	COG0604	alcohol dehydrogenase
GWC92_08690	COG1902	pentaerythritol trinitrate reductase activity
GWC92_08695	COG1253	flavin adenine dinucleotide binding
GWC92_08705	COG0277	FAD linked oxidase domain protein
GWC92_08705	COG0247	lactate metabolic process
GWC92_08715	COG2050	protein possibly involved in aromatic compounds catabolism
GWC92_08730	COG5001	Diguanylate cyclase
GWC92_08735	COG0583	DNA-binding transcription factor activity
GWC92_08740	COG2814	Major facilitator Superfamily
GWC92_08745	COG2056	Na+-H+ antiporter family
GWC92_08750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_08765	COG0483	inositol monophosphate 1-phosphatase activity
GWC92_08775	COG0625	glutathione transferase activity
GWC92_08780	COG0625	glutathione transferase activity
GWC92_08790	COG0601	transmembrane transport
GWC92_08795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_08800	COG0444	Belongs to the ABC transporter superfamily
GWC92_08805	COG2814	Major facilitator Superfamily
GWC92_08825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_08830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_08835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWC92_08840	COG0509	glycine decarboxylation via glycine cleavage system
GWC92_08845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWC92_08845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWC92_08870	COG3634	alkyl hydroperoxide reductase activity
GWC92_08875	COG0450	alkyl hydroperoxide reductase
GWC92_08880	COG0517	IMP dehydrogenase activity
GWC92_08885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWC92_08890	COG0343	queuine tRNA-ribosyltransferase activity
GWC92_08895	COG1862	Preprotein translocase
GWC92_08900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_08905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_08910	COG2897	thiosulfate sulfurtransferase activity
GWC92_08920	COG0826	peptidase U32
GWC92_08925	COG0826	peptidase U32
GWC92_08930	COG3154	lipid carrier protein
GWC92_08945	COG1104	cysteine desulfurase activity
GWC92_08950	COG0822	iron-sulfur transferase activity
GWC92_08960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWC92_08965	COG0443	Heat shock 70 kDa protein
GWC92_08970	COG0633	Ferredoxin
GWC92_08980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_08985	COG0105	UTP biosynthetic process
GWC92_08990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWC92_09000	COG1426	Protein conserved in bacteria
GWC92_09010	COG0124	histidyl-tRNA synthetase
GWC92_09015	COG2976	Protein conserved in bacteria
GWC92_09020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_09025	COG1160	GTP binding
GWC92_09030	COG1645	bacterial-type flagellum-dependent swarming motility
GWC92_09035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWC92_09040	COG0047	phosphoribosylformylglycinamidine synthase activity
GWC92_09040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWC92_09045	COG1007	ATP synthesis coupled electron transport
GWC92_09050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_09060	COG0713	ATP synthesis coupled electron transport
GWC92_09065	COG0839	Belongs to the complex I subunit 6 family
GWC92_09070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_09075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWC92_09080	COG1034	ATP synthesis coupled electron transport
GWC92_09095	COG0649	NAD binding
GWC92_09095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_09100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_09105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_09110	COG1360	Flagellar Motor Protein
GWC92_09115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_09130	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWC92_09140	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWC92_09150	COG0724	RNA recognition motif
GWC92_09155	COG4989	oxidoreductase activity
GWC92_09180	COG0745	RESPONSE REGULATOR receiver
GWC92_09185	COG0583	DNA-binding transcription factor activity
GWC92_09195	COG3300	MHYT domain
GWC92_09195	COG5001	Diguanylate cyclase
GWC92_09200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWC92_09230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWC92_09235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWC92_09240	COG0539	negative regulation of cytoplasmic translation
GWC92_09245	COG0776	regulation of translation
GWC92_09255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWC92_09275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWC92_09280	COG0602	queuosine metabolic process
GWC92_09285	COG3530	Putative quorum-sensing-regulated virulence factor
GWC92_09290	COG2096	Adenosyltransferase
GWC92_09295	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWC92_09300	COG1757	Na H antiporter
GWC92_09305	COG1435	thymidine kinase activity
GWC92_09325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GWC92_09340	COG1349	DNA-binding transcription factor activity
GWC92_09345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWC92_09365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWC92_09370	COG0626	cystathionine gamma-synthase activity
GWC92_09380	COG2910	NAD(P)H-binding
GWC92_09385	COG0583	DNA-binding transcription factor activity
GWC92_09390	COG1917	Cupin 2, conserved barrel domain protein
GWC92_09390	COG4977	sequence-specific DNA binding
GWC92_09395	COG2200	EAL domain
GWC92_09400	COG3706	GGDEF domain
GWC92_09405	COG4774	siderophore transport
GWC92_09415	COG0583	DNA-binding transcription factor activity
GWC92_09420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWC92_09430	COG0617	tRNA 3'-terminal CCA addition
GWC92_09430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWC92_09430	COG0517	IMP dehydrogenase activity
GWC92_09435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_09440	COG3046	protein related to deoxyribodipyrimidine photolyase
GWC92_09455	COG3088	subunit of a heme lyase
GWC92_09455	COG4235	cytochrome complex assembly
GWC92_09460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_09465	COG1138	Cytochrome C-type biogenesis protein
GWC92_09470	COG3301	Polysulphide reductase, NrfD
GWC92_09475	COG0437	4 iron, 4 sulfur cluster binding
GWC92_09480	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWC92_09500	COG0247	lactate metabolic process
GWC92_09510	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWC92_09515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWC92_09520	COG3012	SEC-C Motif Domain Protein
GWC92_09525	COG0840	transmembrane signaling receptor activity
GWC92_09530	COG1846	Transcriptional regulator
GWC92_09530	COG1940	carbohydrate kinase activity
GWC92_09535	COG3290	protein histidine kinase activity
GWC92_09540	COG4565	transcriptional regulatory protein
GWC92_09555	COG3181	Tripartite tricarboxylate transporter family receptor
GWC92_09560	COG0739	heme binding
GWC92_09560	COG1196	nuclear chromosome segregation
GWC92_09560	COG0741	lytic transglycosylase activity
GWC92_09565	COG2985	domain, Protein
GWC92_09565	COG0569	domain protein
GWC92_09575	COG0556	nucleotide-excision repair
GWC92_09585	COG0586	Pfam SNARE associated Golgi protein
GWC92_09590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWC92_09595	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWC92_09600	COG2186	Transcriptional regulator
GWC92_09605	COG2719	SpoVR family
GWC92_09610	COG2718	Belongs to the UPF0229 family
GWC92_09615	COG2766	serine protein kinase
GWC92_09620	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_09625	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWC92_09630	COG0814	amino acid
GWC92_09660	COG0058	SHG alpha-glucan phosphorylase activity
GWC92_09670	COG0471	metal ion transport
GWC92_09675	COG3118	belongs to the thioredoxin family
GWC92_09685	COG1132	(ABC) transporter
GWC92_09690	COG1132	(ABC) transporter
GWC92_09710	COG2501	S4 domain
GWC92_09720	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWC92_09745	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWC92_09750	COG2329	Antibiotic biosynthesis monooxygenase
GWC92_09785	COG0513	Belongs to the DEAD box helicase family
GWC92_09790	COG0386	Belongs to the glutathione peroxidase family
GWC92_09800	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWC92_09805	COG3148	PFAM DTW domain containing protein
GWC92_09815	COG0730	response to heat
GWC92_09820	COG0583	DNA-binding transcription factor activity
GWC92_09835	COG3593	DNA synthesis involved in DNA repair
GWC92_09875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_09880	COG1011	Hydrolase
GWC92_09885	COG1473	amidohydrolase
GWC92_09890	COG0205	6-phosphofructokinase activity
GWC92_09900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWC92_09905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_09915	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWC92_09920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWC92_09950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GWC92_09955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_09970	COG0588	phosphoglycerate mutase activity
GWC92_09985	COG1280	lysine exporter protein (LysE YggA)
GWC92_10000	COG2824	Alkylphosphonate utilization operon protein PhnA
GWC92_10035	COG2840	Smr protein MutS2
GWC92_10040	COG2890	protein-(glutamine-N5) methyltransferase activity
GWC92_10045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWC92_10055	COG0513	Belongs to the DEAD box helicase family
GWC92_10060	COG5654	RES domain protein
GWC92_10070	COG0814	amino acid
GWC92_10075	COG1609	Transcriptional regulator
GWC92_10080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_10080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_10085	COG1105	Belongs to the carbohydrate kinase PfkB family
GWC92_10090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWC92_10090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWC92_10090	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWC92_10095	COG3313	Fe-S protein
GWC92_10100	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWC92_10105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_10110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_10115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_10125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_10150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWC92_10155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWC92_10160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWC92_10165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWC92_10170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWC92_10175	COG0072	phenylalanine-tRNA ligase activity
GWC92_10175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_10180	COG0776	regulation of translation
GWC92_10210	COG3300	MHYT domain
GWC92_10210	COG5001	Diguanylate cyclase
GWC92_10215	COG1609	Transcriptional regulator
GWC92_10220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_10225	COG1879	ABC-type sugar transport system periplasmic component
GWC92_10230	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_10235	COG1129	ABC transporter
GWC92_10240	COG1869	D-ribose catabolic process
GWC92_10245	COG0625	glutathione transferase activity
GWC92_10260	COG0037	tRNA processing
GWC92_10265	COG0589	response to stress
GWC92_10270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWC92_10285	COG2217	Heavy metal translocating P-type atpase
GWC92_10295	COG2010	Cytochrome c
GWC92_10310	COG3278	Belongs to the heme-copper respiratory oxidase family
GWC92_10320	COG1956	GAF domain-containing protein
GWC92_10325	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWC92_10335	COG0308	aminopeptidase N
GWC92_10345	COG2902	Dehydrogenase
GWC92_10350	COG0167	dihydroorotate dehydrogenase activity
GWC92_10360	COG0116	Belongs to the methyltransferase superfamily
GWC92_10360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWC92_10370	COG0488	(ABC) transporter
GWC92_10385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWC92_10390	COG1067	ATP-dependent peptidase activity
GWC92_10400	COG3141	response to X-ray
GWC92_10410	COG2995	paraquat-inducible protein a
GWC92_10415	COG3008	intermembrane lipid transfer
GWC92_10420	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWC92_10420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_10450	COG0084	hydrolase, TatD family'
GWC92_10455	COG0470	DNA polymerase III
GWC92_10460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWC92_10465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWC92_10470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWC92_10475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWC92_10480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWC92_10485	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_10495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWC92_10500	COG0416	fatty acid biosynthetic process
GWC92_10505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWC92_10510	COG1399	metal-binding, possibly nucleic acid-binding protein
GWC92_10525	COG0564	pseudouridine synthase activity
GWC92_10530	COG1530	ribonuclease E activity
GWC92_10535	COG0306	phosphate transporter
GWC92_10540	COG0717	Belongs to the dCTP deaminase family
GWC92_10545	COG0572	uridine kinase
GWC92_10550	COG0489	protein tyrosine kinase activity
GWC92_10555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_10555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_10560	COG0625	glutathione transferase activity
GWC92_10565	COG1254	Belongs to the acylphosphatase family
GWC92_10570	COG0840	transmembrane signaling receptor activity
GWC92_10575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWC92_10590	COG0709	Synthesizes selenophosphate from selenide and ATP
GWC92_10595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWC92_10600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWC92_10605	COG3437	response regulator, receiver
GWC92_10615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWC92_10625	COG1643	Atp-dependent helicase
GWC92_10630	COG0517	IMP dehydrogenase activity
GWC92_10630	COG0617	tRNA 3'-terminal CCA addition
GWC92_10630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWC92_10635	COG2197	response regulator
GWC92_10640	COG3314	Sporulation integral membrane protein YlbJ
GWC92_10650	COG0583	DNA-binding transcription factor activity
GWC92_10655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWC92_10665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWC92_10670	COG2832	Protein of unknown function (DUF454)
GWC92_10675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWC92_10685	COG0697	spore germination
GWC92_10700	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_10705	COG0596	Alpha beta hydrolase
GWC92_10715	COG1214	PFAM Peptidase M22, glycoprotease
GWC92_10720	COG1199	ATP-dependent helicase activity
GWC92_10730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWC92_10735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWC92_10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWC92_10745	COG0131	Imidazoleglycerol-phosphate dehydratase
GWC92_10745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWC92_10750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWC92_10755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWC92_10760	COG3437	response regulator, receiver
GWC92_10770	COG0784	Response regulator, receiver
GWC92_10770	COG2205	protein histidine kinase activity
GWC92_10770	COG2198	Histidine kinase
GWC92_10775	COG0107	imidazoleglycerol-phosphate synthase activity
GWC92_10780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWC92_10780	COG0140	phosphoribosyl-ATP diphosphatase activity
GWC92_10790	COG2378	regulation of single-species biofilm formation
GWC92_10795	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_10800	COG3134	Outer membrane lipoprotein
GWC92_10815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_10840	COG4681	YaeQ
GWC92_10850	COG1024	Enoyl-CoA hydratase
GWC92_10850	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWC92_10855	COG0183	Belongs to the thiolase family
GWC92_10860	COG0714	Associated with various cellular activities
GWC92_10890	COG1595	DNA-templated transcription, initiation
GWC92_10900	COG2067	long-chain fatty acid transport protein
GWC92_10905	COG2067	long-chain fatty acid transport protein
GWC92_10910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWC92_10925	COG1301	dicarboxylic acid transport
GWC92_10930	COG3123	guanosine phosphorylase activity
GWC92_10935	COG1760	l-serine dehydratase
GWC92_10940	COG1760	l-serine dehydratase
GWC92_10945	COG2951	lytic endotransglycosylase activity
GWC92_10950	COG3100	YcgL domain-containing protein
GWC92_10955	COG0850	regulation of cytokinetic process
GWC92_10960	COG2894	cell division
GWC92_10965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWC92_10970	COG3099	Belongs to the UPF0263 family
GWC92_10975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWC92_10990	COG2996	Protein conserved in bacteria
GWC92_11015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWC92_11020	COG0697	spore germination
GWC92_11025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWC92_11030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_11045	COG0307	riboflavin synthase, alpha
GWC92_11055	COG0534	Mate efflux family protein
GWC92_11085	COG0417	DNA replication proofreading
GWC92_11100	COG1560	Kdo2-lipid A biosynthetic process
GWC92_11105	COG1560	Kdo2-lipid A biosynthetic process
GWC92_11115	COG0583	DNA-binding transcription factor activity
GWC92_11120	COG0673	inositol 2-dehydrogenase activity
GWC92_11125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWC92_11145	COG0583	DNA-binding transcription factor activity
GWC92_11155	COG2723	6-phospho-beta-galactosidase activity
GWC92_11160	COG0583	DNA-binding transcription factor activity
GWC92_11170	COG0243	molybdopterin cofactor binding
GWC92_11175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWC92_11190	COG0583	DNA-binding transcription factor activity
GWC92_11195	COG1879	ABC-type sugar transport system periplasmic component
GWC92_11200	COG1129	ABC transporter
GWC92_11205	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_11210	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_11225	COG0702	epimerase
GWC92_11230	COG1073	alpha beta
GWC92_11235	COG1073	alpha beta
GWC92_11285	COG0730	response to heat
GWC92_11295	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_11305	COG1024	Enoyl-CoA hydratase
GWC92_11310	COG1024	Enoyl-CoA hydratase
GWC92_11315	COG1960	acyl-CoA dehydrogenase activity
GWC92_11325	COG1960	acyl-CoA dehydrogenase activity
GWC92_11330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWC92_11335	COG1024	Enoyl-CoA hydratase
GWC92_11360	COG1584	GPR1 FUN34 yaaH family protein
GWC92_11365	COG3228	Belongs to the MtfA family
GWC92_11375	COG1115	amino acid carrier protein
GWC92_11380	COG1024	Enoyl-CoA hydratase
GWC92_11395	COG3162	membrane
GWC92_11400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWC92_11405	COG0488	(ABC) transporter
GWC92_11410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWC92_11415	COG0776	regulation of translation
GWC92_11420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWC92_11425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWC92_11430	COG0740	serine-type endopeptidase activity
GWC92_11435	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWC92_11445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GWC92_11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWC92_11455	COG1136	(ABC) transporter
GWC92_11460	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWC92_11470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWC92_11475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWC92_11500	COG2062	phosphohistidine phosphatase, SixA
GWC92_11510	COG0500	methyltransferase
GWC92_11520	COG1846	Transcriptional regulator
GWC92_11585	COG0789	Transcriptional regulator
GWC92_11665	COG0582	viral genome integration into host DNA
GWC92_11670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWC92_11670	COG0519	Catalyzes the synthesis of GMP from XMP
GWC92_11675	COG0516	GMP reductase activity
GWC92_11675	COG0517	IMP dehydrogenase activity
GWC92_11685	COG1874	Beta-galactosidase
GWC92_11685	COG0366	Alpha amylase catalytic
GWC92_11695	COG1570	exodeoxyribonuclease VII activity
GWC92_11705	COG2885	chlorophyll binding
GWC92_11725	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWC92_11735	COG3768	UPF0283 membrane protein
GWC92_11740	COG3106	COG3106 Predicted ATPase
GWC92_11755	COG1842	Phage shock protein A
GWC92_11760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWC92_11775	COG4171	peptide transport system, permease
GWC92_11785	COG4172	Belongs to the ABC transporter superfamily
GWC92_11795	COG1609	Transcriptional regulator
GWC92_11800	COG1263	PTS System
GWC92_11800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_11805	COG2723	6-phospho-beta-galactosidase activity
GWC92_11810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWC92_11815	COG1286	toxin biosynthetic process
GWC92_11820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWC92_11825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWC92_11830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWC92_11835	COG0531	amino acid
GWC92_11835	COG1674	ftsk spoiiie
GWC92_11845	COG0686	Belongs to the AlaDH PNT family
GWC92_11850	COG0492	ferredoxin-NADP+ reductase activity
GWC92_11855	COG3706	GGDEF domain
GWC92_11860	COG3134	Outer membrane lipoprotein
GWC92_11865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWC92_11870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWC92_11875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWC92_11880	COG0542	response to heat
GWC92_11885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWC92_11890	COG1278	Cold shock
GWC92_11895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWC92_11910	COG1944	ATP diphosphatase activity
GWC92_11915	COG2116	formate transmembrane transporter activity
GWC92_11920	COG1882	Formate acetyltransferase
GWC92_11925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_11930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWC92_11935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWC92_11945	COG1840	ABC-type Fe3 transport system, periplasmic component
GWC92_11950	COG3842	ATPase activity
GWC92_11960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_11965	COG2983	Belongs to the UPF0260 family
GWC92_11980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWC92_11985	COG0045	succinate-CoA ligase (ADP-forming) activity
GWC92_11990	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWC92_11995	COG0567	Dehydrogenase, E1 component
GWC92_12010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWC92_12015	COG2009	succinate dehydrogenase
GWC92_12035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWC92_12040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_12040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWC92_12050	COG3069	C4-dicarboxylate transmembrane transporter activity
GWC92_12065	COG1451	nucleotide metabolic process
GWC92_12080	COG0254	rRNA binding
GWC92_12085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWC92_12095	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_12100	COG1129	ABC transporter
GWC92_12105	COG1879	ABC-type sugar transport system periplasmic component
GWC92_12110	COG1069	ribulokinase activity
GWC92_12120	COG2160	L-arabinose isomerase activity
GWC92_12125	COG0583	DNA-binding transcription factor activity
GWC92_12130	COG0436	Aminotransferase
GWC92_12135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_12150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWC92_12150	COG0392	lysyltransferase activity
GWC92_12175	COG1263	PTS System
GWC92_12175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_12180	COG1874	Beta-galactosidase
GWC92_12185	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GWC92_12190	COG3833	ABC-type maltose transport systems, permease component
GWC92_12195	COG1175	transmembrane transport
GWC92_12200	COG2182	Extracellular solute-binding protein
GWC92_12225	COG4580	involved in the transport of maltose and maltodextrins
GWC92_12230	COG1609	Transcriptional regulator
GWC92_12235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_12240	COG1085	galactose-1-phosphate uridylyltransferase
GWC92_12245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWC92_12275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWC92_12290	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GWC92_12320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWC92_12340	COG2925	Exonuclease
GWC92_12350	COG3345	alpha-galactosidase
GWC92_12355	COG1380	Effector of murein hydrolase LrgA
GWC92_12360	COG1346	cytolysis
GWC92_12365	COG0295	cytidine deaminase activity
GWC92_12370	COG1022	Amp-dependent synthetase and ligase
GWC92_12385	COG0861	Integral membrane protein TerC family
GWC92_12390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_12395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWC92_12400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWC92_12440	COG4771	TonB-dependent receptor
GWC92_12445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_12450	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_12455	COG1120	ATPase activity
GWC92_12470	COG0300	oxidoreductase activity
GWC92_12470	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_12470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWC92_12470	COG3321	synthase
GWC92_12470	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_12480	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_12485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWC92_12490	COG1535	isochorismatase
GWC92_12490	COG3433	isochorismatase activity
GWC92_12495	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWC92_12520	COG3300	MHYT domain
GWC92_12520	COG5001	Diguanylate cyclase
GWC92_12535	COG0840	transmembrane signaling receptor activity
GWC92_12540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_12545	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWC92_12550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWC92_12555	COG0563	adenylate kinase activity
GWC92_12560	COG0326	Molecular chaperone. Has ATPase activity
GWC92_12565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWC92_12570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GWC92_12575	COG0298	carbon dioxide binding
GWC92_12585	COG0309	Hydrogenase expression formation protein (HypE)
GWC92_12590	COG0375	protein maturation
GWC92_12595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWC92_12600	COG1124	(ABC) transporter
GWC92_12605	COG0444	Belongs to the ABC transporter superfamily
GWC92_12610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_12625	COG1773	rubredoxin
GWC92_12630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GWC92_12635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GWC92_12640	COG5557	Pfam Polysulphide reductase, NrfD
GWC92_12645	COG0437	4 iron, 4 sulfur cluster binding
GWC92_12650	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GWC92_12655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_12665	COG0659	secondary active sulfate transmembrane transporter activity
GWC92_12685	COG2308	Evidence 4 Homologs of previously reported genes of
GWC92_12720	COG0672	)-iron permease
GWC92_12745	COG2814	Major facilitator Superfamily
GWC92_12765	COG1136	(ABC) transporter
GWC92_12770	COG0577	efflux transmembrane transporter activity
GWC92_12800	COG1139	Iron-sulfur cluster binding protein
GWC92_12805	COG0247	lactate metabolic process
GWC92_12810	COG1620	l-lactate permease
GWC92_12815	COG0583	DNA-binding transcription factor activity
GWC92_12840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWC92_12845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWC92_12845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWC92_12850	COG0527	aspartate kinase activity
GWC92_12860	COG1368	sulfuric ester hydrolase activity
GWC92_12865	COG0393	Putative heavy-metal-binding
GWC92_12875	COG1252	NADH dehydrogenase
GWC92_12880	COG3150	esterase
GWC92_12885	COG1164	Oligoendopeptidase f
GWC92_12890	COG1164	Oligoendopeptidase f
GWC92_12895	COG2354	Protein conserved in bacteria
GWC92_12910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_12915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_12950	COG0537	adenosine 5'-monophosphoramidase activity
GWC92_12965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWC92_12985	COG1301	dicarboxylic acid transport
GWC92_12995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_13000	COG0861	Integral membrane protein TerC family
GWC92_13010	COG0444	Belongs to the ABC transporter superfamily
GWC92_13015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_13020	COG0601	transmembrane transport
GWC92_13030	COG2095	MarC family integral membrane protein
GWC92_13035	COG1454	alcohol dehydrogenase
GWC92_13035	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_13045	COG3275	phosphorelay sensor kinase activity
GWC92_13050	COG3279	Response regulator of the LytR AlgR family
GWC92_13055	COG1966	Carbon starvation protein
GWC92_13060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWC92_13060	COG3264	Mechanosensitive ion channel
GWC92_13070	COG1566	PFAM secretion protein HlyD family protein
GWC92_13075	COG1061	Type III restriction enzyme res subunit
GWC92_13080	COG2027	D-alanyl-D-alanine carboxypeptidase
GWC92_13085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWC92_13095	COG0436	Aminotransferase
GWC92_13100	COG1288	antiporter activity
GWC92_13105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWC92_13180	COG4397	Mu-like prophage major head subunit gpT
GWC92_13185	COG4388	Caudovirus prohead serine protease
GWC92_13205	COG4383	Mu-like prophage protein gp29
GWC92_13210	COG4373	Mu-like prophage FluMu protein gp28
GWC92_13220	COG0640	Transcriptional regulator
GWC92_13325	COG2932	Transcriptional regulator
GWC92_13345	COG0697	spore germination
GWC92_13350	COG4657	Part of a membrane complex involved in electron transport
GWC92_13355	COG2878	Part of a membrane complex involved in electron transport
GWC92_13365	COG4658	electron transport chain
GWC92_13370	COG4659	FMN binding
GWC92_13375	COG4660	Part of a membrane complex involved in electron transport
GWC92_13380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWC92_13385	COG0346	lactoylglutathione lyase activity
GWC92_13410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWC92_13420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWC92_13425	COG1086	Polysaccharide biosynthesis protein
GWC92_13430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWC92_13440	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GWC92_13445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWC92_13460	COG2089	acid synthase
GWC92_13500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWC92_13520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_13520	COG0301	tRNA thio-modification
GWC92_13530	COG4953	penicillin-binding protein 1C
GWC92_13535	COG2373	Large extracellular alpha-helical protein
GWC92_13540	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_13550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWC92_13560	COG4160	amino acid transport
GWC92_13570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_13580	COG2431	L-lysine efflux transmembrane transporter activity
GWC92_13585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWC92_13590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_13615	COG1393	Belongs to the ArsC family
GWC92_13625	COG4783	chaperone-mediated protein folding
GWC92_13630	COG0425	Belongs to the sulfur carrier protein TusA family
GWC92_13645	COG0596	Alpha beta hydrolase
GWC92_13655	COG3842	ATPase activity
GWC92_13660	COG3833	ABC-type maltose transport systems, permease component
GWC92_13665	COG1175	transmembrane transport
GWC92_13675	COG3081	Nucleoid-associated protein
GWC92_13680	COG3082	Protein of unknown function (DUF1414)
GWC92_13685	COG3083	sulfuric ester hydrolase activity
GWC92_13690	COG4771	TonB-dependent receptor
GWC92_13695	COG1770	oligopeptidase
GWC92_13715	COG4574	serine-type endopeptidase inhibitor activity
GWC92_13720	COG3085	chromosome segregation
GWC92_13730	COG1605	Chorismate mutase
GWC92_13730	COG0287	Prephenate dehydrogenase
GWC92_13735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_13740	COG0584	glycerophosphoryl diester phosphodiesterase
GWC92_13750	COG1349	DNA-binding transcription factor activity
GWC92_13755	COG2271	Major facilitator Superfamily
GWC92_13760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWC92_13765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWC92_13770	COG0583	DNA-binding transcription factor activity
GWC92_13790	COG0656	L-ascorbic acid biosynthetic process
GWC92_13795	COG2814	Major facilitator Superfamily
GWC92_13815	COG1294	oxidase, subunit
GWC92_13825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_13835	COG2979	Protein of unknown function (DUF533)
GWC92_13855	COG0583	DNA-binding transcription factor activity
GWC92_13865	COG2807	transmembrane transport
GWC92_13870	COG1187	pseudouridine synthase activity
GWC92_13875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWC92_13900	COG1061	Type III restriction enzyme res subunit
GWC92_13925	COG1166	arginine decarboxylase activity
GWC92_13930	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWC92_13945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWC92_13960	COG0583	DNA-binding transcription factor activity
GWC92_13970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWC92_13975	COG0840	transmembrane signaling receptor activity
GWC92_13980	COG0302	gtp cyclohydrolase
GWC92_13990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWC92_14005	COG2267	carboxylic ester hydrolase activity
GWC92_14010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWC92_14025	COG0314	molybdopterin synthase activity
GWC92_14030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWC92_14035	COG0315	cyclic pyranopterin monophosphate synthase activity
GWC92_14040	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWC92_14045	COG3005	denitrification pathway
GWC92_14055	COG0348	domain, Protein
GWC92_14060	COG0437	4 iron, 4 sulfur cluster binding
GWC92_14065	COG0243	molybdopterin cofactor binding
GWC92_14075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_14075	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_14080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWC92_14085	COG3850	Histidine kinase
GWC92_14090	COG2197	response regulator
GWC92_14115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWC92_14125	COG0121	glutamine amidotransferase
GWC92_14130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWC92_14135	COG1960	acyl-CoA dehydrogenase activity
GWC92_14140	COG0784	Response regulator, receiver
GWC92_14140	COG3437	response regulator, receiver
GWC92_14150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_14155	COG0328	RNA-DNA hybrid ribonuclease activity
GWC92_14160	COG2226	methyltransferase
GWC92_14165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWC92_14170	COG0741	lytic transglycosylase activity
GWC92_14170	COG1388	LysM domain
GWC92_14185	COG1607	acyl-coa hydrolase
GWC92_14200	COG0741	lytic transglycosylase activity
GWC92_14210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWC92_14235	COG2911	Protein conserved in bacteria
GWC92_14240	COG0729	surface antigen
GWC92_14250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWC92_14260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWC92_14265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_14270	COG4134	Bacterial extracellular solute-binding protein
GWC92_14280	COG4136	ATPase activity
GWC92_14285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWC92_14290	COG2951	lytic endotransglycosylase activity
GWC92_14295	COG1846	Transcriptional regulator
GWC92_14305	COG0033	Phosphoglucomutase
GWC92_14310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWC92_14315	COG0596	Alpha beta hydrolase
GWC92_14330	COG0716	FMN binding
GWC92_14340	COG0735	belongs to the Fur family
GWC92_14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_14355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_14355	COG2190	(PTS) system
GWC92_14355	COG1263	PTS System
GWC92_14360	COG0363	glucosamine-6-phosphate deaminase activity
GWC92_14365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWC92_14370	COG1940	carbohydrate kinase activity
GWC92_14370	COG1846	Transcriptional regulator
GWC92_14375	COG2194	sulfuric ester hydrolase activity
GWC92_14380	COG0217	transcriptional regulatory protein
GWC92_14385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWC92_14395	COG1801	Protein of unknown function DUF72
GWC92_14400	COG4106	trans-aconitate 2-methyltransferase activity
GWC92_14405	COG0500	methyltransferase
GWC92_14425	COG0583	DNA-binding transcription factor activity
GWC92_14430	COG0791	NLP P60 protein
GWC92_14445	COG1309	transcriptional regulator
GWC92_14455	COG1454	alcohol dehydrogenase
GWC92_14480	COG0534	Mate efflux family protein
GWC92_14490	COG2841	Protein conserved in bacteria
GWC92_14510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWC92_14510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWC92_14510	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWC92_14510	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWC92_14520	COG3217	Mosc domain protein beta barrel domain protein
GWC92_14520	COG0633	Ferredoxin
GWC92_14520	COG3217	Mosc domain protein beta barrel domain protein
GWC92_14520	COG0633	Ferredoxin
GWC92_14525	COG0501	Belongs to the peptidase M48B family
GWC92_14530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWC92_14535	COG2226	methyltransferase
GWC92_14535	COG1073	alpha beta
GWC92_14540	COG0156	8-amino-7-oxononanoate synthase activity
GWC92_14545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWC92_14565	COG0017	Asparaginyl-tRNA synthetase
GWC92_14570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWC92_14580	COG1473	amidohydrolase
GWC92_14585	COG3069	C4-dicarboxylate transmembrane transporter activity
GWC92_14595	COG1393	Belongs to the ArsC family
GWC92_14600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWC92_14605	COG1876	peptidase activity
GWC92_14615	COG3263	regulation of cellular component size
GWC92_14625	COG1280	lysine exporter protein (LysE YggA)
GWC92_14655	COG1957	nucleoside hydrolase
GWC92_14660	COG0564	pseudouridine synthase activity
GWC92_14670	COG1454	alcohol dehydrogenase
GWC92_14675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_14680	COG0702	epimerase
GWC92_14685	COG2914	Belongs to the UPF0125 (RnfH) family
GWC92_14690	COG2867	negative regulation of translational initiation
GWC92_14695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWC92_14710	COG0800	Aldolase
GWC92_14725	COG3153	acetyltransferase
GWC92_14755	COG0259	pyridoxamine-phosphate oxidase activity
GWC92_14770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_14770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_14775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWC92_14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_14805	COG1138	Cytochrome C-type biogenesis protein
GWC92_14810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWC92_14815	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_14820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_14825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_14840	COG0835	chemotaxis
GWC92_14850	COG1192	Involved in chromosome partitioning
GWC92_14855	COG1360	Flagellar Motor Protein
GWC92_14860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_14865	COG2201	protein-glutamate methylesterase activity
GWC92_14870	COG0784	Response regulator, receiver
GWC92_14870	COG2198	Histidine kinase
GWC92_14870	COG0643	Histidine kinase
GWC92_14875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWC92_14900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWC92_14910	COG1684	flagellar biosynthetic protein fliR
GWC92_14965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWC92_14975	COG1677	Flagellar hook-basal body complex protein FliE
GWC92_14990	COG1393	Belongs to the ArsC family
GWC92_14995	COG0798	PFAM Bile acid sodium symporter
GWC92_15000	COG0640	Transcriptional regulator
GWC92_15010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWC92_15025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_15030	COG0444	Belongs to the ABC transporter superfamily
GWC92_15035	COG4608	Belongs to the ABC transporter superfamily
GWC92_15045	COG2971	BadF BadG BcrA BcrD
GWC92_15055	COG0840	transmembrane signaling receptor activity
GWC92_15070	COG3724	N-succinylarginine dihydrolase activity
GWC92_15075	COG0616	signal peptide processing
GWC92_15080	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_15085	COG0583	DNA-binding transcription factor activity
GWC92_15095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWC92_15105	COG0583	DNA-binding transcription factor activity
GWC92_15110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWC92_15115	COG1881	PFAM PEBP family protein
GWC92_15125	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GWC92_15125	COG3408	Glycogen debranching enzyme
GWC92_15130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWC92_15135	COG0739	heme binding
GWC92_15140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWC92_15165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWC92_15175	COG3091	SprT-like family
GWC92_15185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWC92_15190	COG0189	ligase activity
GWC92_15200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWC92_15220	COG1115	amino acid carrier protein
GWC92_15225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWC92_15240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWC92_15250	COG1301	dicarboxylic acid transport
GWC92_15255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWC92_15260	COG2912	Transglutaminase-like superfamily
GWC92_15270	COG2890	protein-(glutamine-N5) methyltransferase activity
GWC92_15275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWC92_15280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWC92_15285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWC92_15290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWC92_15300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWC92_15305	COG0193	aminoacyl-tRNA hydrolase activity
GWC92_15310	COG0012	GTP binding
GWC92_15355	COG0471	metal ion transport
GWC92_15355	COG0490	domain, Protein
GWC92_15440	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_15450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWC92_15465	COG0180	Tryptophanyl-tRNA synthetase
GWC92_15470	COG0546	phosphoglycolate phosphatase activity
GWC92_15475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWC92_15480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWC92_15490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWC92_15495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWC92_15525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWC92_15530	COG0583	DNA-binding transcription factor activity
GWC92_15545	COG0583	DNA-binding transcription factor activity
GWC92_15555	COG0739	heme binding
GWC92_15565	COG1511	domain protein
GWC92_15565	COG3264	Mechanosensitive ion channel
GWC92_15570	COG0584	glycerophosphoryl diester phosphodiesterase
GWC92_15580	COG1053	succinate dehydrogenase
GWC92_15585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWC92_15590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWC92_15595	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWC92_15610	COG3214	Protein conserved in bacteria
GWC92_15615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_15635	COG0300	oxidoreductase activity
GWC92_15655	COG0189	ligase activity
GWC92_15655	COG4067	protein conserved in archaea
GWC92_15660	COG0516	GMP reductase activity
GWC92_15670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWC92_15675	COG2011	ABC-type metal ion transport system permease component
GWC92_15680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWC92_15685	COG1464	Belongs to the NlpA lipoprotein family
GWC92_15700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWC92_15710	COG2199	diguanylate cyclase activity
GWC92_15720	COG2199	diguanylate cyclase activity
GWC92_15725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_15740	COG1335	isochorismatase
GWC92_15745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_15750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWC92_15755	COG1702	phosphate starvation-inducible protein PhoH
GWC92_15760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWC92_15765	COG4535	Mg2 and Co2 transporter CorC
GWC92_15770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWC92_15775	COG2888	peptidyl-tyrosine sulfation
GWC92_15780	COG0495	leucyl-tRNA aminoacylation
GWC92_15795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWC92_15800	COG0799	negative regulation of ribosome biogenesis
GWC92_15805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWC92_15810	COG0768	penicillin binding
GWC92_15815	COG0772	Belongs to the SEDS family
GWC92_15820	COG2951	lytic endotransglycosylase activity
GWC92_15825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWC92_15830	COG1686	Belongs to the peptidase S11 family
GWC92_15835	COG2921	Belongs to the UPF0250 family
GWC92_15840	COG0321	lipoyl(octanoyl) transferase activity
GWC92_15845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWC92_15855	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_15870	COG0789	Transcriptional regulator
GWC92_15875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWC92_15885	COG1970	mechanosensitive ion channel activity
GWC92_15890	COG4974	Belongs to the 'phage' integrase family
GWC92_15900	COG0312	modulator of DNA gyrase
GWC92_15905	COG0312	modulator of DNA gyrase
GWC92_15920	COG0826	peptidase U32
GWC92_15925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_15935	COG1422	Protein of unknown function (DUF1090)
GWC92_15940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWC92_15945	COG2211	Major facilitator Superfamily
GWC92_15950	COG1185	polyribonucleotide nucleotidyltransferase activity
GWC92_15955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWC92_15960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWC92_15965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWC92_15970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWC92_15975	COG0195	Participates in both transcription termination and antitermination
GWC92_15980	COG0779	Required for maturation of 30S ribosomal subunits
GWC92_15995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWC92_16000	COG0149	triose-phosphate isomerase activity
GWC92_16005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWC92_16010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWC92_16020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWC92_16025	COG1534	Rna-binding protein
GWC92_16040	COG1360	Flagellar Motor Protein
GWC92_16045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_16050	COG1722	exodeoxyribonuclease VII activity
GWC92_16055	COG0142	geranyltranstransferase activity
GWC92_16060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWC92_16065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_16070	COG0601	transmembrane transport
GWC92_16080	COG4172	Belongs to the ABC transporter superfamily
GWC92_16085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWC92_16090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWC92_16095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_16100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWC92_16115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWC92_16115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWC92_16120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWC92_16150	COG3550	peptidyl-serine autophosphorylation
GWC92_16180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWC92_16190	COG3381	protein complex oligomerization
GWC92_16210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWC92_16215	COG0511	ligase activity, forming carbon-carbon bonds
GWC92_16220	COG0439	Biotin carboxylase
GWC92_16225	COG3924	membrane
GWC92_16230	COG4145	pantothenate transmembrane transporter activity
GWC92_16235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_16235	COG1263	PTS System
GWC92_16235	COG2190	(PTS) system
GWC92_16240	COG0583	DNA-binding transcription factor activity
GWC92_16245	COG0604	alcohol dehydrogenase
GWC92_16250	COG2264	protein methyltransferase activity
GWC92_16255	COG0110	maltose O-acetyltransferase activity
GWC92_16265	COG0778	Nitroreductase
GWC92_16270	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_16270	COG1902	pentaerythritol trinitrate reductase activity
GWC92_16275	COG0616	signal peptide processing
GWC92_16295	COG3139	Protein of unknown function (DUF1315)
GWC92_16300	COG0252	asparaginase activity
GWC92_16305	COG0786	glutamate:sodium symporter activity
GWC92_16320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWC92_16325	COG0384	phenazine biosynthesis protein PhzF
GWC92_16330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWC92_16335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_16340	COG0175	sulfate reduction
GWC92_16345	COG2113	Glycine betaine
GWC92_16350	COG4176	ABC-type proline glycine betaine transport system permease component
GWC92_16355	COG4175	Glycine betaine
GWC92_16365	COG3610	response to peptide
GWC92_16370	COG2966	Psort location CytoplasmicMembrane, score
GWC92_16380	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWC92_16405	COG2313	pseudouridylate synthase activity
GWC92_16410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_16415	COG2146	nitrite reductase [NAD(P)H] activity
GWC92_16415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_16420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_16420	COG2146	nitrite reductase [NAD(P)H] activity
GWC92_16425	COG1116	anion transmembrane transporter activity
GWC92_16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWC92_16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWC92_16435	COG1116	anion transmembrane transporter activity
GWC92_16445	COG1648	precorrin-2 dehydrogenase activity
GWC92_16445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_16450	COG0243	molybdopterin cofactor binding
GWC92_16475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWC92_16490	COG1073	alpha beta
GWC92_16495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWC92_16505	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWC92_16515	COG4608	Belongs to the ABC transporter superfamily
GWC92_16520	COG0444	Belongs to the ABC transporter superfamily
GWC92_16530	COG4239	(ABC) transporter, permease
GWC92_16535	COG4174	ABC transporter (Permease)
GWC92_16540	COG4206	TonB-dependent receptor
GWC92_16550	COG0811	peptide transport
GWC92_16555	COG0811	peptide transport
GWC92_16560	COG0848	biopolymer transport protein
GWC92_16610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_16615	COG0840	transmembrane signaling receptor activity
GWC92_16625	COG1278	Cold shock
GWC92_16665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWC92_16670	COG1162	GTPase activity
GWC92_16675	COG0688	phosphatidylethanolamine metabolic process
GWC92_16680	COG4628	conserved protein (DUF2132)
GWC92_16700	COG5001	Diguanylate cyclase
GWC92_16700	COG3300	MHYT domain
GWC92_16705	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWC92_16730	COG1132	(ABC) transporter
GWC92_16740	COG2897	thiosulfate sulfurtransferase activity
GWC92_16745	COG2066	Belongs to the glutaminase family
GWC92_16750	COG3171	Protein conserved in bacteria
GWC92_16755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWC92_16760	COG4935	Belongs to the peptidase S8 family
GWC92_16760	COG2234	aminopeptidase activity
GWC92_16765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_16770	COG2200	EAL domain
GWC92_16775	COG1090	epimerase
GWC92_16780	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWC92_16785	COG4181	ATPase activity
GWC92_16790	COG2755	lipolytic protein G-D-S-L family
GWC92_16795	COG0784	Response regulator, receiver
GWC92_16795	COG0835	chemotaxis
GWC92_16805	COG0517	IMP dehydrogenase activity
GWC92_16805	COG0516	GMP reductase activity
GWC92_16810	COG0488	(ABC) transporter
GWC92_16820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWC92_16865	COG0789	Transcriptional regulator
GWC92_16875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWC92_16885	COG0668	transmembrane transport
GWC92_16895	COG2731	YhcH YjgK YiaL family protein
GWC92_16905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_16910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_16915	COG3227	Zinc metalloprotease (Elastase)
GWC92_16920	COG0583	DNA-binding transcription factor activity
GWC92_16925	COG0477	Major facilitator Superfamily
GWC92_16935	COG2985	domain, Protein
GWC92_16935	COG0569	domain protein
GWC92_16940	COG1272	protein, Hemolysin III
GWC92_16945	COG0076	glutamate decarboxylase activity
GWC92_16950	COG2917	probably involved in intracellular septation
GWC92_16955	COG2350	Protein conserved in bacteria
GWC92_16965	COG1555	photosystem II stabilization
GWC92_16970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWC92_16975	COG3104	oligopeptide transport
GWC92_16980	COG0745	RESPONSE REGULATOR receiver
GWC92_17010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_17025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWC92_17030	COG1280	lysine exporter protein (LysE YggA)
GWC92_17055	COG0316	Belongs to the HesB IscA family
GWC92_17065	COG0038	chloride channel
GWC92_17070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWC92_17085	COG0671	phosphoesterase, PA-phosphatase related
GWC92_17095	COG0583	DNA-binding transcription factor activity
GWC92_17100	COG2076	Multidrug Resistance protein
GWC92_17110	COG0346	lactoylglutathione lyase activity
GWC92_17115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWC92_17120	COG1643	Atp-dependent helicase
GWC92_17130	COG1489	DNA binding
GWC92_17135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWC92_17140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_17150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWC92_17155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWC92_17160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWC92_17170	COG0842	Transport permease protein
GWC92_17175	COG1131	(ABC) transporter
GWC92_17190	COG0163	prenyltransferase activity
GWC92_17195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWC92_17200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWC92_17215	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWC92_17230	COG1136	(ABC) transporter
GWC92_17300	COG0529	Catalyzes the synthesis of activated sulfate
GWC92_17305	COG0471	metal ion transport
GWC92_17305	COG3273	potassium ion transport
GWC92_17310	COG2895	sulfate adenylyltransferase (ATP) activity
GWC92_17315	COG0175	sulfate reduction
GWC92_17320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_17320	COG1648	precorrin-2 dehydrogenase activity
GWC92_17325	COG0330	HflC and HflK could
GWC92_17330	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWC92_17340	COG0673	inositol 2-dehydrogenase activity
GWC92_17350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWC92_17355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWC92_17360	COG3036	rescue of stalled ribosome
GWC92_17375	COG0138	bifunctional purine biosynthesis protein purh
GWC92_17410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWC92_17415	COG0358	DNA primase activity
GWC92_17420	COG1610	YqeY-like protein
GWC92_17425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWC92_17430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWC92_17440	COG1388	LysM domain
GWC92_17440	COG4942	peptidase
GWC92_17445	COG1238	metal cluster binding
GWC92_17450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWC92_17455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWC92_17460	COG0585	pseudouridine synthase activity
GWC92_17470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWC92_17475	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWC92_17480	COG0148	phosphopyruvate hydratase activity
GWC92_17485	COG0504	CTP synthase activity
GWC92_17490	COG3956	TIGRFAM MazG family protein
GWC92_17495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWC92_17500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_17510	COG4807	Protein conserved in bacteria
GWC92_17515	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWC92_17520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWC92_17525	COG1381	Involved in DNA repair and RecF pathway recombination
GWC92_17535	COG0571	ribonuclease III activity
GWC92_17540	COG0681	Belongs to the peptidase S26 family
GWC92_17545	COG0481	GTPase activity
GWC92_17560	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GWC92_17565	COG1595	DNA-templated transcription, initiation
GWC92_17570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWC92_17580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWC92_17590	COG0583	DNA-binding transcription factor activity
GWC92_17625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_17635	COG0126	phosphoglycerate kinase activity
GWC92_17640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWC92_17645	COG1940	carbohydrate kinase activity
GWC92_17650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWC92_17655	COG2816	NAD+ diphosphatase activity
GWC92_17660	COG4991	sh3 domain protein
GWC92_17665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWC92_17680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWC92_17685	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_17695	COG1505	serine-type exopeptidase activity
GWC92_17700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWC92_17705	COG0765	amino acid transport
GWC92_17710	COG0765	amino acid transport
GWC92_17715	COG1126	abc transporter atp-binding protein
GWC92_17720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_17725	COG3174	membrane
GWC92_17730	COG0110	maltose O-acetyltransferase activity
GWC92_17770	COG0583	DNA-binding transcription factor activity
GWC92_17775	COG0165	Argininosuccinate lyase
GWC92_17780	COG0137	argininosuccinate synthase activity
GWC92_17790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWC92_17795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWC92_17805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWC92_17815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWC92_17850	COG0583	DNA-binding transcription factor activity
GWC92_17855	COG1380	Effector of murein hydrolase LrgA
GWC92_17860	COG1346	cytolysis
GWC92_17865	COG0460	homoserine dehydrogenase
GWC92_17865	COG0527	aspartate kinase activity
GWC92_17870	COG0626	cystathionine gamma-synthase activity
GWC92_17885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_17890	COG0814	amino acid
GWC92_17895	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWC92_17900	COG0494	nUDIX hydrolase
GWC92_17905	COG1011	Hydrolase
GWC92_17920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWC92_17935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWC92_17945	COG3156	type II secretion system protein K
GWC92_17950	COG4795	General secretion pathway protein
GWC92_17955	COG2165	general secretion pathway protein
GWC92_17965	COG2165	general secretion pathway protein
GWC92_17970	COG1459	type II secretion system
GWC92_17975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWC92_17985	COG3031	protein transport across the cell outer membrane
GWC92_17995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWC92_18000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWC92_18015	COG0456	acetyltransferase
GWC92_18020	COG3133	Outer membrane lipoprotein
GWC92_18025	COG3025	triphosphatase activity
GWC92_18030	COG1392	Phosphate transport regulator
GWC92_18035	COG0306	phosphate transporter
GWC92_18040	COG0617	tRNA 3'-terminal CCA addition
GWC92_18045	COG3267	Type II secretory pathway component ExeA
GWC92_18045	COG3409	Peptidoglycan-binding domain 1 protein
GWC92_18055	COG1194	a g-specific adenine glycosylase
GWC92_18060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWC92_18075	COG3240	lipase activity
GWC92_18085	COG3009	Protein conserved in bacteria
GWC92_18090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWC92_18090	COG3008	intermembrane lipid transfer
GWC92_18095	COG2995	paraquat-inducible protein a
GWC92_18105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_18110	COG5001	Diguanylate cyclase
GWC92_18110	COG4251	negative regulation of phosphorylation
GWC92_18110	COG3706	GGDEF domain
GWC92_18110	COG2203	Gaf domain
GWC92_18115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWC92_18120	COG2813	Specifically methylates the guanine in position
GWC92_18125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWC92_18130	COG0297	glycogen (starch) synthase activity
GWC92_18170	COG1757	Na H antiporter
GWC92_18175	COG0583	DNA-binding transcription factor activity
GWC92_18180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GWC92_18185	COG3842	ATPase activity
GWC92_18190	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWC92_18195	COG1177	transmembrane transport
GWC92_18200	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_18205	COG0109	protoheme IX farnesyltransferase activity
GWC92_18235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWC92_18245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWC92_18245	COG1565	acr, cog1565
GWC92_18250	COG1444	tRNA N-acetyltransferase activity
GWC92_18270	COG1803	Methylglyoxal synthase
GWC92_18285	COG0252	asparaginase activity
GWC92_18305	COG1263	PTS System
GWC92_18305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_18310	COG0366	Alpha amylase catalytic
GWC92_18315	COG0110	maltose O-acetyltransferase activity
GWC92_18320	COG1522	sequence-specific DNA binding
GWC92_18350	COG3068	Protein conserved in bacteria
GWC92_18360	COG0739	heme binding
GWC92_18380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWC92_18385	COG1121	(ABC) transporter
GWC92_18390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWC92_18395	COG0583	DNA-binding transcription factor activity
GWC92_18405	COG1573	uracil-dna glycosylase
GWC92_18410	COG2962	Rard protein
GWC92_18415	COG2827	Endonuclease containing a URI domain
GWC92_18430	COG1842	Phage shock protein A
GWC92_18435	COG0204	Acyl-transferase
GWC92_18455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_18465	COG0484	heat shock protein binding
GWC92_18500	COG2801	Transposase and inactivated derivatives
GWC92_18515	COG1289	transmembrane transporter activity
GWC92_18520	COG1566	PFAM secretion protein HlyD family protein
GWC92_18535	COG1051	belongs to the nudix hydrolase family
GWC92_18540	COG3150	esterase
GWC92_18550	COG3151	Protein conserved in bacteria
GWC92_18555	COG0494	nUDIX hydrolase
GWC92_18560	COG1538	Outer membrane efflux protein
GWC92_18565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWC92_18565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWC92_18570	COG1560	Kdo2-lipid A biosynthetic process
GWC92_18585	COG2771	luxR family
GWC92_18590	COG3916	Acyl-homoserine-lactone synthase
GWC92_18600	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWC92_18605	COG2213	PTS system mannitol-specific
GWC92_18605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_18610	COG0246	Mannitol dehydrogenase
GWC92_18615	COG3722	fumarate hydratase activity
GWC92_18620	COG3263	regulation of cellular component size
GWC92_18640	COG1671	Belongs to the UPF0178 family
GWC92_18655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_18660	COG0513	Belongs to the DEAD box helicase family
GWC92_18680	COG1575	Belongs to the MenA family. Type 1 subfamily
GWC92_18685	COG1169	isochorismate synthase
GWC92_18690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWC92_18695	COG0596	Alpha beta hydrolase
GWC92_18700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWC92_18710	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_18715	COG3291	Pkd domain containing protein
GWC92_18720	COG2949	membrane
GWC92_18725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWC92_18735	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWC92_18765	COG2873	o-acetylhomoserine
GWC92_18775	COG1979	alcohol dehydrogenase
GWC92_18790	COG4221	oxidoreductase activity
GWC92_18810	COG1285	pathogenesis
GWC92_18825	COG1368	sulfuric ester hydrolase activity
GWC92_18830	COG1522	sequence-specific DNA binding
GWC92_18840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWC92_18850	COG1546	Belongs to the CinA family
GWC92_18850	COG1058	Belongs to the CinA family
GWC92_18855	COG1988	membrane-bound metal-dependent
GWC92_18870	COG0561	phosphatase activity
GWC92_18875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWC92_18885	COG1011	Hydrolase
GWC92_18900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWC92_18905	COG0019	diaminopimelate decarboxylase activity
GWC92_18915	COG1965	Belongs to the frataxin family
GWC92_18920	COG0400	carboxylic ester hydrolase activity
GWC92_18925	COG3072	Adenylate cyclase
GWC92_18930	COG0181	hydroxymethylbilane synthase activity
GWC92_18935	COG1587	Uroporphyrinogen-III synthase
GWC92_18940	COG2959	enzyme of heme biosynthesis
GWC92_18945	COG3071	HemY protein
GWC92_18950	COG0312	modulator of DNA gyrase
GWC92_18955	COG3028	Belongs to the UPF0307 family
GWC92_18965	COG2926	Belongs to the UPF0265 family
GWC92_18995	COG1396	sequence-specific DNA binding
GWC92_19000	COG3135	benzoate transporter
GWC92_19025	COG0840	transmembrane signaling receptor activity
GWC92_19030	COG3047	cAMP biosynthetic process
GWC92_19035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWC92_19040	COG2197	response regulator
GWC92_19085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_19115	COG2801	Transposase and inactivated derivatives
GWC92_19125	COG1396	sequence-specific DNA binding
GWC92_19150	COG1278	Cold shock
GWC92_19180	COG3706	GGDEF domain
GWC92_19185	COG0347	Belongs to the P(II) protein family
GWC92_19190	COG0004	ammonium transporteR
GWC92_19215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_19220	COG1074	ATP-dependent DNA helicase activity
GWC92_19225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWC92_19230	COG2259	Doxx family
GWC92_19235	COG1741	Belongs to the pirin family
GWC92_19245	COG0583	DNA-binding transcription factor activity
GWC92_19270	COG1175	transmembrane transport
GWC92_19280	COG3842	ATPase activity
GWC92_19310	COG0456	acetyltransferase
GWC92_19315	COG0753	catalase activity
GWC92_19335	COG0494	nUDIX hydrolase
GWC92_19340	COG0628	permease
GWC92_19350	COG2957	Belongs to the agmatine deiminase family
GWC92_19365	COG2957	Belongs to the agmatine deiminase family
GWC92_19370	COG0583	DNA-binding transcription factor activity
GWC92_19385	COG1461	Dihydroxyacetone kinase
GWC92_19390	COG2376	Dihydroxyacetone kinase
GWC92_19395	COG2252	PERMEase
GWC92_19400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWC92_19430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWC92_19435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWC92_19440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWC92_19445	COG0049	tRNA binding
GWC92_19450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWC92_19455	COG2168	tRNA wobble position uridine thiolation
GWC92_19465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWC92_19470	COG0251	oxidation-reduction process
GWC92_19475	COG2964	Protein conserved in bacteria
GWC92_19480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWC92_19485	COG0085	RNA polymerase activity
GWC92_19490	COG0222	ribosome binding
GWC92_19495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWC92_19500	COG0081	regulation of translation
GWC92_19505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWC92_19510	COG0250	Participates in transcription elongation, termination and antitermination
GWC92_19525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWC92_19550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWC92_19555	COG0569	domain protein
GWC92_19560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_19565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWC92_19570	COG3005	denitrification pathway
GWC92_19575	COG0243	molybdopterin cofactor binding
GWC92_19610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWC92_19625	COG2204	response regulator
GWC92_19635	COG2205	protein histidine kinase activity
GWC92_19655	COG0516	GMP reductase activity
GWC92_19655	COG0517	IMP dehydrogenase activity
GWC92_19665	COG1522	sequence-specific DNA binding
GWC92_19670	COG2502	aspartate--ammonia ligase
GWC92_19685	COG0583	DNA-binding transcription factor activity
GWC92_19695	COG5001	Diguanylate cyclase
GWC92_19695	COG4251	negative regulation of phosphorylation
GWC92_19695	COG3706	GGDEF domain
GWC92_19695	COG2203	Gaf domain
GWC92_19715	COG0814	amino acid
GWC92_19720	COG0814	amino acid
GWC92_19725	COG3033	Beta-eliminating lyase
GWC92_19735	COG0348	domain, Protein
GWC92_19745	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_19750	COG0426	domain, Protein
GWC92_19750	COG1773	rubredoxin
GWC92_19755	COG3604	Transcriptional regulator
GWC92_19785	COG0751	glycine-tRNA ligase activity
GWC92_19790	COG0752	glycyl-tRNA synthetase alpha subunit
GWC92_19795	COG2818	Glycosylase
GWC92_19800	COG1335	isochorismatase
GWC92_19810	COG2885	chlorophyll binding
GWC92_19815	COG0251	oxidation-reduction process
GWC92_19820	COG0425	Belongs to the sulfur carrier protein TusA family
GWC92_19850	COG0183	Belongs to the thiolase family
GWC92_19855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWC92_19855	COG1024	Enoyl-CoA hydratase
GWC92_19860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWC92_19865	COG0006	proline dipeptidase activity
GWC92_19870	COG1739	Uncharacterized protein family UPF0029
GWC92_19875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_19880	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWC92_19915	COG0045	succinate-CoA ligase (ADP-forming) activity
GWC92_19915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_19915	COG1042	CoA-binding domain protein
GWC92_19925	COG0583	DNA-binding transcription factor activity
GWC92_19930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWC92_19935	COG0166	Belongs to the GPI family
GWC92_19945	COG0668	transmembrane transport
GWC92_19965	COG1309	transcriptional regulator
GWC92_19970	COG0756	dUTP diphosphatase activity
GWC92_19975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWC92_19980	COG2003	Belongs to the UPF0758 family
GWC92_19985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWC92_19990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWC92_20000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWC92_20005	COG2990	Protein conserved in bacteria
GWC92_20010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWC92_20015	COG0859	PFAM glycosyl transferase family 9
GWC92_20020	COG0463	Glycosyl transferase, family 2
GWC92_20025	COG0859	PFAM glycosyl transferase family 9
GWC92_20030	COG1519	Transferase
GWC92_20040	COG1561	YicC-like family, N-terminal region
GWC92_20045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWC92_20050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWC92_20065	COG4251	negative regulation of phosphorylation
GWC92_20065	COG2203	Gaf domain
GWC92_20065	COG3706	GGDEF domain
GWC92_20065	COG5001	Diguanylate cyclase
GWC92_20070	COG3084	Protein conserved in bacteria
GWC92_20080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWC92_20085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWC92_20095	COG1335	isochorismatase
GWC92_20105	COG1683	Conserved Protein
GWC92_20110	COG0204	Acyl-transferase
GWC92_20115	COG0204	Acyl-transferase
GWC92_20120	COG0606	chelatase, subunit chli
GWC92_20135	COG3978	acetolactate synthase activity
GWC92_20145	COG0129	dihydroxy-acid dehydratase activity
GWC92_20165	COG1309	transcriptional regulator
GWC92_20170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWC92_20175	COG0254	rRNA binding
GWC92_20180	COG0702	epimerase
GWC92_20185	COG0281	malic enzyme
GWC92_20195	COG2205	protein histidine kinase activity
GWC92_20200	COG0745	RESPONSE REGULATOR receiver
GWC92_20205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_20240	COG4310	Domain of unknown function (DUF2172)
GWC92_20250	COG0366	Alpha amylase catalytic
GWC92_20265	COG0443	Heat shock 70 kDa protein
GWC92_20270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWC92_20275	COG3045	CreA protein
GWC92_20295	COG0174	glutamine synthetase
GWC92_20315	COG3842	ATPase activity
GWC92_20320	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWC92_20325	COG1177	transmembrane transport
GWC92_20330	COG2258	MOSC domain
GWC92_20345	COG2050	protein possibly involved in aromatic compounds catabolism
GWC92_20350	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_20355	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_20365	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWC92_20375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWC92_20380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWC92_20385	COG2239	Acts as a magnesium transporter
GWC92_20390	COG1648	precorrin-2 dehydrogenase activity
GWC92_20390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_20395	COG2116	formate transmembrane transporter activity
GWC92_20405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_20410	COG0842	Transport permease protein
GWC92_20415	COG0842	Transport permease protein
GWC92_20420	COG1131	(ABC) transporter
GWC92_20425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_20440	COG0477	Major facilitator Superfamily
GWC92_20445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWC92_20450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWC92_20470	COG1595	DNA-templated transcription, initiation
GWC92_20475	COG3806	Anti-sigma factor
GWC92_20480	COG1968	undecaprenyl-diphosphatase activity
GWC92_20485	COG0667	Aldo Keto reductase
GWC92_20490	COG2017	converts alpha-aldose to the beta-anomer
GWC92_20495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWC92_20505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_20510	COG1609	Transcriptional regulator
GWC92_20515	COG3250	beta-galactosidase activity
GWC92_20555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWC92_20560	COG1288	antiporter activity
GWC92_20565	COG1438	arginine binding
GWC92_20570	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWC92_20575	COG0540	Belongs to the ATCase OTCase family
GWC92_20595	COG0583	DNA-binding transcription factor activity
GWC92_20605	COG0840	transmembrane signaling receptor activity
GWC92_20615	COG3040	lipid binding
GWC92_20620	COG2207	Transcriptional regulator
GWC92_20625	COG1979	alcohol dehydrogenase
GWC92_20630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWC92_20635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWC92_20640	COG2964	Protein conserved in bacteria
GWC92_20645	COG3681	Belongs to the UPF0597 family
GWC92_20650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_20655	COG0564	pseudouridine synthase activity
GWC92_20665	COG0542	response to heat
GWC92_20675	COG1609	Transcriptional regulator
GWC92_20715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_20730	COG2960	long-chain fatty acid transporting porin activity
GWC92_20740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWC92_20755	COG3118	belongs to the thioredoxin family
GWC92_20760	COG0513	Belongs to the DEAD box helicase family
GWC92_20765	COG0248	Ppx GppA phosphatase
GWC92_20775	COG0742	ribosomal rna small subunit methyltransferase
GWC92_20795	COG0084	hydrolase, TatD family'
GWC92_20800	COG0805	protein transport
GWC92_20805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_20810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_20815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWC92_20820	COG3165	ubiquinone biosynthetic process from chorismate
GWC92_20830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWC92_20835	COG0402	S-adenosylhomocysteine deaminase activity
GWC92_20870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWC92_20875	COG0848	biopolymer transport protein
GWC92_20880	COG0811	peptide transport
GWC92_20885	COG0811	peptide transport
GWC92_20895	COG2771	luxR family
GWC92_20900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWC92_20905	COG1349	DNA-binding transcription factor activity
GWC92_20910	COG0745	RESPONSE REGULATOR receiver
GWC92_20915	COG2205	protein histidine kinase activity
GWC92_20925	COG4452	Inner membrane protein CreD
GWC92_20930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWC92_20935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWC92_20940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWC92_20945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWC92_20950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWC92_20955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWC92_20960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWC92_20970	COG0356	it plays a direct role in the translocation of protons across the membrane
GWC92_20980	COG1475	DNA binding
GWC92_20985	COG1192	Involved in chromosome partitioning
GWC92_20990	COG0357	Ribosomal RNA small subunit methyltransferase G
GWC92_20995	COG0445	tRNA wobble uridine modification
GWC92_21000	COG0716	FMN binding
GWC92_21010	COG4615	Cyclic peptide transporter
GWC92_21015	COG1120	ATPase activity
GWC92_21020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWC92_21030	COG3550	peptidyl-serine autophosphorylation
GWC92_21080	COG1695	Transcriptional regulator
GWC92_21100	COG3173	Aminoglycoside phosphotransferase
GWC92_21185	COG4974	Belongs to the 'phage' integrase family
GWC92_21190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWC92_21195	COG0706	membrane insertase activity
GWC92_21200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWC92_21205	COG0594	ribonuclease P activity
GWC92_21210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWC92_21215	COG1126	abc transporter atp-binding protein