locus-tag	class	description
C0708_00115	COG4584	PFAM Integrase catalytic
C0708_00120	COG1484	DNA-dependent DNA replication
C0708_00130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0708_00135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0708_00155	COG0668	transmembrane transport
C0708_00165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0708_00175	COG0789	Transcriptional regulator
C0708_00220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0708_00230	COG0488	(ABC) transporter
C0708_00235	COG0517	IMP dehydrogenase activity
C0708_00235	COG0516	GMP reductase activity
C0708_00245	COG0675	Transposase, IS605 OrfB family
C0708_00255	COG0835	chemotaxis
C0708_00255	COG0784	Response regulator, receiver
C0708_00260	COG2755	lipolytic protein G-D-S-L family
C0708_00265	COG4181	ATPase activity
C0708_00270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C0708_00275	COG1090	epimerase
C0708_00280	COG2200	EAL domain
C0708_00285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0708_00295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0708_00300	COG3171	Protein conserved in bacteria
C0708_00305	COG2066	Belongs to the glutaminase family
C0708_00310	COG2897	thiosulfate sulfurtransferase activity
C0708_00345	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C0708_00350	COG5001	Diguanylate cyclase
C0708_00350	COG3300	MHYT domain
C0708_00370	COG4628	conserved protein (DUF2132)
C0708_00375	COG0688	phosphatidylethanolamine metabolic process
C0708_00380	COG1162	GTPase activity
C0708_00385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0708_00425	COG1278	Cold shock
C0708_00435	COG0840	transmembrane signaling receptor activity
C0708_00440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_00445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_00450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_00455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_00505	COG0848	biopolymer transport protein
C0708_00510	COG0811	peptide transport
C0708_00515	COG0811	peptide transport
C0708_00525	COG4206	TonB-dependent receptor
C0708_00530	COG4174	ABC transporter (Permease)
C0708_00535	COG4239	(ABC) transporter, permease
C0708_00550	COG4608	Belongs to the ABC transporter superfamily
C0708_00570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C0708_00590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0708_00615	COG0243	molybdopterin cofactor binding
C0708_00630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0708_00630	COG1116	anion transmembrane transporter activity
C0708_00635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0708_00650	COG2146	nitrite reductase [NAD(P)H] activity
C0708_00650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0708_00660	COG2313	pseudouridylate synthase activity
C0708_00680	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0708_00690	COG2966	Psort location CytoplasmicMembrane, score
C0708_00695	COG3610	response to peptide
C0708_00705	COG4175	Glycine betaine
C0708_00710	COG4176	ABC-type proline glycine betaine transport system permease component
C0708_00715	COG2113	Glycine betaine
C0708_00720	COG0175	sulfate reduction
C0708_00725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0708_00730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0708_00735	COG0384	phenazine biosynthesis protein PhzF
C0708_00740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0708_00765	COG0786	glutamate:sodium symporter activity
C0708_00770	COG0252	asparaginase activity
C0708_00775	COG3139	Protein of unknown function (DUF1315)
C0708_00800	COG0616	signal peptide processing
C0708_00810	COG0778	Nitroreductase
C0708_00825	COG0110	maltose O-acetyltransferase activity
C0708_00830	COG2264	protein methyltransferase activity
C0708_00835	COG0604	alcohol dehydrogenase
C0708_00840	COG0583	DNA-binding transcription factor activity
C0708_00850	COG4145	pantothenate transmembrane transporter activity
C0708_00855	COG3924	membrane
C0708_00860	COG0439	Biotin carboxylase
C0708_00865	COG0511	ligase activity, forming carbon-carbon bonds
C0708_00870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0708_00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0708_00890	COG3381	protein complex oligomerization
C0708_00900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0708_00910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0708_00915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0708_00915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0708_00930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0708_00935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0708_00940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C0708_00945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0708_00950	COG4172	Belongs to the ABC transporter superfamily
C0708_00975	COG0142	geranyltranstransferase activity
C0708_00980	COG1722	exodeoxyribonuclease VII activity
C0708_00985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0708_00990	COG1360	Flagellar Motor Protein
C0708_00995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0708_01005	COG1534	Rna-binding protein
C0708_01010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0708_01015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0708_01020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0708_01025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0708_01030	COG0149	triose-phosphate isomerase activity
C0708_01035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0708_01050	COG0779	Required for maturation of 30S ribosomal subunits
C0708_01055	COG0195	Participates in both transcription termination and antitermination
C0708_01060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0708_01065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0708_01070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0708_01075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0708_01080	COG1185	polyribonucleotide nucleotidyltransferase activity
C0708_01085	COG2211	Major facilitator Superfamily
C0708_01090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0708_01095	COG1422	Protein of unknown function (DUF1090)
C0708_01110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0708_01130	COG0312	modulator of DNA gyrase
C0708_01140	COG0312	modulator of DNA gyrase
C0708_01145	COG0716	FMN binding
C0708_01150	COG4974	Belongs to the 'phage' integrase family
C0708_01155	COG1970	mechanosensitive ion channel activity
C0708_01180	COG0789	Transcriptional regulator
C0708_01195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0708_01205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0708_01220	COG2921	Belongs to the UPF0250 family
C0708_01230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0708_01235	COG2951	lytic endotransglycosylase activity
C0708_01250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0708_01255	COG0799	negative regulation of ribosome biogenesis
C0708_01260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0708_01275	COG0495	leucyl-tRNA aminoacylation
C0708_01280	COG2888	peptidyl-tyrosine sulfation
C0708_01285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0708_01290	COG4535	Mg2 and Co2 transporter CorC
C0708_01295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0708_01300	COG1702	phosphate starvation-inducible protein PhoH
C0708_01340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0708_01365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0708_01380	COG1464	Belongs to the NlpA lipoprotein family
C0708_01390	COG2011	ABC-type metal ion transport system permease component
C0708_01395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0708_01405	COG0516	GMP reductase activity
C0708_01410	COG0189	ligase activity
C0708_01410	COG4067	protein conserved in archaea
C0708_01420	COG0745	RESPONSE REGULATOR receiver
C0708_01430	COG0300	oxidoreductase activity
C0708_01450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0708_01470	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C0708_01475	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C0708_01480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0708_01485	COG1053	succinate dehydrogenase
C0708_01495	COG0584	glycerophosphoryl diester phosphodiesterase
C0708_01500	COG1511	domain protein
C0708_01500	COG3264	Mechanosensitive ion channel
C0708_01510	COG0739	heme binding
C0708_01525	COG0583	DNA-binding transcription factor activity
C0708_01575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0708_01580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0708_01590	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C0708_01595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0708_01600	COG0546	phosphoglycolate phosphatase activity
C0708_01605	COG0180	Tryptophanyl-tRNA synthetase
C0708_01620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0708_01630	COG1012	belongs to the aldehyde dehydrogenase family
C0708_01645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0708_01670	COG0471	metal ion transport
C0708_01670	COG0490	domain, Protein
C0708_01715	COG0012	GTP binding
C0708_01720	COG0193	aminoacyl-tRNA hydrolase activity
C0708_01725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0708_01735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0708_01740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0708_01745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0708_01750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0708_01755	COG2890	protein-(glutamine-N5) methyltransferase activity
C0708_01770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C0708_01775	COG1301	dicarboxylic acid transport
C0708_01785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0708_01800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0708_01805	COG1115	amino acid carrier protein
C0708_01835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0708_01845	COG0189	ligase activity
C0708_01850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0708_01860	COG3091	SprT-like family
C0708_01870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0708_01885	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C0708_01890	COG0739	heme binding
C0708_01895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0708_01900	COG3408	Glycogen debranching enzyme
C0708_01900	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C0708_01910	COG1881	PFAM PEBP family protein
C0708_01920	COG0583	DNA-binding transcription factor activity
C0708_01930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C0708_01940	COG0583	DNA-binding transcription factor activity
C0708_01945	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_01950	COG0616	signal peptide processing
C0708_01955	COG3724	N-succinylarginine dihydrolase activity
C0708_01960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0708_01970	COG0840	transmembrane signaling receptor activity
C0708_01980	COG2971	BadF BadG BcrA BcrD
C0708_01990	COG4608	Belongs to the ABC transporter superfamily
C0708_02000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0708_02025	COG0640	Transcriptional regulator
C0708_02030	COG0798	PFAM Bile acid sodium symporter
C0708_02035	COG1393	Belongs to the ArsC family
C0708_02045	COG1677	Flagellar hook-basal body complex protein FliE
C0708_02055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0708_02105	COG1987	bacterial-type flagellum assembly
C0708_02110	COG1684	flagellar biosynthetic protein fliR
C0708_02130	COG0455	bacterial-type flagellum organization
C0708_02145	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C0708_02150	COG0643	Histidine kinase
C0708_02150	COG2198	Histidine kinase
C0708_02155	COG2201	protein-glutamate methylesterase activity
C0708_02165	COG1360	Flagellar Motor Protein
C0708_02170	COG1192	Involved in chromosome partitioning
C0708_02180	COG0835	chemotaxis
C0708_02195	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0708_02200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0708_02205	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0708_02210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C0708_02220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0708_02230	COG0457	Tetratricopeptide repeat
C0708_02250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0708_02255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0708_02255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0708_02270	COG0259	pyridoxamine-phosphate oxidase activity
C0708_02300	COG3153	acetyltransferase
C0708_02315	COG0800	Aldolase
C0708_02320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0708_02335	COG3311	Transcriptional regulator
C0708_02345	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0708_02385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0708_02410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0708_02465	COG0582	viral genome integration into host DNA
C0708_02475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0708_02480	COG2867	negative regulation of translational initiation
C0708_02490	COG0702	epimerase
C0708_02495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0708_02500	COG1454	alcohol dehydrogenase
C0708_02505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C0708_02515	COG1957	nucleoside hydrolase
C0708_02540	COG1280	lysine exporter protein (LysE YggA)
C0708_02550	COG3263	regulation of cellular component size
C0708_02560	COG1876	peptidase activity
C0708_02565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0708_02570	COG1393	Belongs to the ArsC family
C0708_02580	COG3069	C4-dicarboxylate transmembrane transporter activity
C0708_02595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C0708_02600	COG0017	Asparaginyl-tRNA synthetase
C0708_02620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0708_02630	COG2226	methyltransferase
C0708_02630	COG1073	alpha beta
C0708_02635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0708_02640	COG0501	Belongs to the peptidase M48B family
C0708_02660	COG2841	Protein conserved in bacteria
C0708_02705	COG1309	transcriptional regulator
C0708_02720	COG0791	NLP P60 protein
C0708_02725	COG0583	DNA-binding transcription factor activity
C0708_02745	COG0500	methyltransferase
C0708_02750	COG4106	trans-aconitate 2-methyltransferase activity
C0708_02755	COG1801	Protein of unknown function DUF72
C0708_02765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0708_02770	COG0217	transcriptional regulatory protein
C0708_02780	COG2194	sulfuric ester hydrolase activity
C0708_02785	COG1846	Transcriptional regulator
C0708_02785	COG1940	carbohydrate kinase activity
C0708_02790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0708_02795	COG0363	glucosamine-6-phosphate deaminase activity
C0708_02800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0708_02800	COG2190	(PTS) system
C0708_02800	COG1263	PTS System
C0708_02810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_02815	COG0735	belongs to the Fur family
C0708_02825	COG0716	FMN binding
C0708_02840	COG0596	Alpha beta hydrolase
C0708_02845	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C0708_02850	COG0033	Phosphoglucomutase
C0708_02860	COG1846	Transcriptional regulator
C0708_02865	COG2951	lytic endotransglycosylase activity
C0708_02870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0708_02895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0708_02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0708_02920	COG2911	Protein conserved in bacteria
C0708_02935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0708_02945	COG0741	lytic transglycosylase activity
C0708_02960	COG1607	acyl-coa hydrolase
C0708_02970	COG3021	interspecies interaction between organisms
C0708_02975	COG1388	LysM domain
C0708_02975	COG0741	lytic transglycosylase activity
C0708_02980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0708_02985	COG2226	methyltransferase
C0708_02990	COG0328	RNA-DNA hybrid ribonuclease activity
C0708_03030	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0708_03050	COG2850	peptidyl-arginine hydroxylation
C0708_03085	COG1484	DNA-dependent DNA replication
C0708_03090	COG4584	PFAM Integrase catalytic
C0708_03100	COG0210	DNA helicase
C0708_03105	COG4974	Belongs to the 'phage' integrase family
C0708_03110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0708_03120	COG0784	Response regulator, receiver
C0708_03120	COG3437	response regulator, receiver
C0708_03125	COG1960	acyl-CoA dehydrogenase activity
C0708_03130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0708_03135	COG0121	glutamine amidotransferase
C0708_03145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C0708_03155	COG2205	protein histidine kinase activity
C0708_03155	COG0784	Response regulator, receiver
C0708_03170	COG2197	response regulator
C0708_03175	COG3850	Histidine kinase
C0708_03180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0708_03185	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0708_03185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0708_03195	COG0243	molybdopterin cofactor binding
C0708_03200	COG0437	4 iron, 4 sulfur cluster binding
C0708_03205	COG0348	domain, Protein
C0708_03215	COG3005	denitrification pathway
C0708_03220	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0708_03225	COG0315	cyclic pyranopterin monophosphate synthase activity
C0708_03235	COG0314	molybdopterin synthase activity
C0708_03255	COG2267	carboxylic ester hydrolase activity
C0708_03260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0708_03270	COG0302	gtp cyclohydrolase
C0708_03275	COG0840	transmembrane signaling receptor activity
C0708_03280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C0708_03290	COG0583	DNA-binding transcription factor activity
C0708_03320	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0708_03375	COG0675	Transposase, IS605 OrfB family
C0708_03385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0708_03390	COG1187	pseudouridine synthase activity
C0708_03405	COG0583	DNA-binding transcription factor activity
C0708_03425	COG2979	Protein of unknown function (DUF533)
C0708_03435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0708_03440	COG1271	oxidase subunit
C0708_03445	COG1294	oxidase, subunit
C0708_03455	COG2814	Major facilitator Superfamily
C0708_03460	COG0656	L-ascorbic acid biosynthetic process
C0708_03480	COG0583	DNA-binding transcription factor activity
C0708_03485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0708_03490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0708_03495	COG2271	Major facilitator Superfamily
C0708_03500	COG1349	DNA-binding transcription factor activity
C0708_03515	COG0584	glycerophosphoryl diester phosphodiesterase
C0708_03520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0708_03525	COG0287	Prephenate dehydrogenase
C0708_03525	COG1605	Chorismate mutase
C0708_03535	COG3085	chromosome segregation
C0708_03540	COG4574	serine-type endopeptidase inhibitor activity
C0708_03565	COG4771	TonB-dependent receptor
C0708_03570	COG3083	sulfuric ester hydrolase activity
C0708_03575	COG3082	Protein of unknown function (DUF1414)
C0708_03590	COG1175	transmembrane transport
C0708_03600	COG3842	ATPase activity
C0708_03610	COG0596	Alpha beta hydrolase
C0708_03625	COG0425	Belongs to the sulfur carrier protein TusA family
C0708_03630	COG4783	chaperone-mediated protein folding
C0708_03640	COG1393	Belongs to the ArsC family
C0708_03670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0708_03675	COG2431	L-lysine efflux transmembrane transporter activity
C0708_03685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_03690	COG4215	(ABC) transporter
C0708_03695	COG4160	amino acid transport
C0708_03705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0708_03715	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0708_03725	COG4953	penicillin-binding protein 1C
C0708_03735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0708_03735	COG0301	tRNA thio-modification
C0708_03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0708_03805	COG4310	Domain of unknown function (DUF2172)
C0708_03820	COG2089	acid synthase
C0708_03830	COG1083	cytidylyl-transferase
C0708_03845	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_03850	COG0318	PFAM AMP-dependent synthetase and ligase
C0708_03865	COG1216	Glycosyl transferase, family 2
C0708_03885	COG0438	transferase activity, transferring glycosyl groups
C0708_03910	COG0438	transferase activity, transferring glycosyl groups
C0708_03915	COG0297	glycogen (starch) synthase activity
C0708_03920	COG0529	Catalyzes the synthesis of activated sulfate
C0708_03930	COG3848	Pyruvate phosphate dikinase
C0708_03930	COG0574	Belongs to the PEP-utilizing enzyme family
C0708_03935	COG0512	Glutamine amidotransferase of anthranilate synthase
C0708_03935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0708_03940	COG1213	nucleotidyl transferase
C0708_03945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0708_03950	COG1086	Polysaccharide biosynthesis protein
C0708_03955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0708_03965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0708_03995	COG0675	Transposase, IS605 OrfB family
C0708_04005	COG0346	lactoylglutathione lyase activity
C0708_04010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0708_04020	COG4659	FMN binding
C0708_04035	COG2878	Part of a membrane complex involved in electron transport
C0708_04040	COG4657	Part of a membrane complex involved in electron transport
C0708_04045	COG0675	Transposase, IS605 OrfB family
C0708_04050	COG5433	transposase activity
C0708_04055	COG3039	Transposase
C0708_04105	COG1288	antiporter activity
C0708_04110	COG0436	Aminotransferase
C0708_04120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C0708_04130	COG1061	Type III restriction enzyme res subunit
C0708_04135	COG1566	PFAM secretion protein HlyD family protein
C0708_04155	COG0675	Transposase, IS605 OrfB family
C0708_04165	COG1966	Carbon starvation protein
C0708_04170	COG3279	Response regulator of the LytR AlgR family
C0708_04175	COG3275	phosphorelay sensor kinase activity
C0708_04185	COG1012	belongs to the aldehyde dehydrogenase family
C0708_04185	COG1454	alcohol dehydrogenase
C0708_04190	COG2095	MarC family integral membrane protein
C0708_04200	COG0601	transmembrane transport
C0708_04205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0708_04210	COG0444	Belongs to the ABC transporter superfamily
C0708_04220	COG0861	Integral membrane protein TerC family
C0708_04225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0708_04235	COG1301	dicarboxylic acid transport
C0708_04255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0708_04270	COG0537	adenosine 5'-monophosphoramidase activity
C0708_04305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0708_04310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0708_04345	COG1252	NADH dehydrogenase
C0708_04350	COG0393	Putative heavy-metal-binding
C0708_04365	COG0527	aspartate kinase activity
C0708_04370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0708_04370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0708_04400	COG0583	DNA-binding transcription factor activity
C0708_04405	COG1620	l-lactate permease
C0708_04410	COG0247	lactate metabolic process
C0708_04455	COG1136	(ABC) transporter
C0708_04500	COG0672	)-iron permease
C0708_04540	COG0675	Transposase, IS605 OrfB family
C0708_04595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0708_04600	COG0326	Molecular chaperone. Has ATPase activity
C0708_04605	COG0563	adenylate kinase activity
C0708_04610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0708_04615	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C0708_04620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0708_04640	COG3300	MHYT domain
C0708_04640	COG5001	Diguanylate cyclase
C0708_04680	COG1535	isochorismatase
C0708_04680	COG3433	isochorismatase activity
C0708_04690	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_04725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0708_04730	COG4771	TonB-dependent receptor
C0708_04750	COG0598	Magnesium transport protein CorA
C0708_04770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0708_04775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0708_04780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0708_04785	COG3385	transposase activity
C0708_04790	COG0861	Integral membrane protein TerC family
C0708_04805	COG1022	Amp-dependent synthetase and ligase
C0708_04815	COG1346	cytolysis
C0708_04820	COG1380	Effector of murein hydrolase LrgA
C0708_04830	COG3385	transposase activity
C0708_04840	COG2925	Exonuclease
C0708_04895	COG5433	transposase activity
C0708_04910	COG1085	galactose-1-phosphate uridylyltransferase
C0708_04915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0708_04925	COG4580	involved in the transport of maltose and maltodextrins
C0708_04970	COG2182	Extracellular solute-binding protein
C0708_04975	COG1175	transmembrane transport
C0708_04980	COG3833	ABC-type maltose transport systems, permease component
C0708_04985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C0708_04990	COG1874	Beta-galactosidase
C0708_04995	COG1263	PTS System
C0708_04995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0708_05005	COG0469	pyruvate kinase activity
C0708_05050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0708_05065	COG2160	L-arabinose isomerase activity
C0708_05075	COG1069	ribulokinase activity
C0708_05080	COG1879	ABC-type sugar transport system periplasmic component
C0708_05090	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0708_05105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0708_05110	COG0254	rRNA binding
C0708_05125	COG1451	nucleotide metabolic process
C0708_05140	COG3069	C4-dicarboxylate transmembrane transporter activity
C0708_05155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0708_05175	COG2009	succinate dehydrogenase
C0708_05180	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C0708_05195	COG0567	Dehydrogenase, E1 component
C0708_05205	COG0045	succinate-CoA ligase (ADP-forming) activity
C0708_05210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0708_05225	COG1882	Formate acetyltransferase
C0708_05230	COG2116	formate transmembrane transporter activity
C0708_05235	COG1944	ATP diphosphatase activity
C0708_05245	COG2076	Multidrug Resistance protein
C0708_05250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0708_05255	COG1278	Cold shock
C0708_05260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0708_05265	COG0542	response to heat
C0708_05270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0708_05275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C0708_05280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0708_05285	COG3134	Outer membrane lipoprotein
C0708_05290	COG3706	GGDEF domain
C0708_05300	COG0492	ferredoxin-NADP+ reductase activity
C0708_05305	COG0686	Belongs to the AlaDH PNT family
C0708_05315	COG0531	amino acid
C0708_05315	COG1674	ftsk spoiiie
C0708_05325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0708_05330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0708_05335	COG1286	toxin biosynthetic process
C0708_05340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0708_05350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0708_05350	COG1263	PTS System
C0708_05365	COG0675	Transposase, IS605 OrfB family
C0708_05380	COG4172	Belongs to the ABC transporter superfamily
C0708_05390	COG4171	peptide transport system, permease
C0708_05395	COG4168	peptide transport system, permease
C0708_05405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C0708_05410	COG1842	Phage shock protein A
C0708_05425	COG3106	COG3106 Predicted ATPase
C0708_05430	COG3768	UPF0283 membrane protein
C0708_05440	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0708_05455	COG2199	diguanylate cyclase activity
C0708_05460	COG2885	chlorophyll binding
C0708_05490	COG0675	Transposase, IS605 OrfB family
C0708_05505	COG0517	IMP dehydrogenase activity
C0708_05505	COG0516	GMP reductase activity
C0708_05510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0708_05510	COG0519	Catalyzes the synthesis of GMP from XMP
C0708_05520	COG0582	viral genome integration into host DNA
C0708_05605	COG0789	Transcriptional regulator
C0708_05655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0708_05695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0708_05805	COG4584	PFAM Integrase catalytic
C0708_05810	COG1484	DNA-dependent DNA replication
C0708_05835	COG1846	Transcriptional regulator
C0708_05855	COG2062	phosphohistidine phosphatase, SixA
C0708_05865	COG0697	spore germination
C0708_05875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C0708_05880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0708_05890	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0708_05895	COG1136	(ABC) transporter
C0708_05900	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0708_05905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C0708_05920	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0708_05925	COG0740	serine-type endopeptidase activity
C0708_05930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0708_05935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0708_05940	COG0776	regulation of translation
C0708_05945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0708_05950	COG0488	(ABC) transporter
C0708_05955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0708_05960	COG3162	membrane
C0708_05975	COG1024	Enoyl-CoA hydratase
C0708_05980	COG1115	amino acid carrier protein
C0708_05990	COG3228	Belongs to the MtfA family
C0708_05995	COG1584	GPR1 FUN34 yaaH family protein
C0708_06020	COG1024	Enoyl-CoA hydratase
C0708_06025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0708_06030	COG1960	acyl-CoA dehydrogenase activity
C0708_06045	COG1024	Enoyl-CoA hydratase
C0708_06050	COG1024	Enoyl-CoA hydratase
C0708_06070	COG0730	response to heat
C0708_06100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C0708_06130	COG4584	PFAM Integrase catalytic
C0708_06135	COG1484	DNA-dependent DNA replication
C0708_06150	COG2003	Belongs to the UPF0758 family
C0708_06160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0708_06190	COG0583	DNA-binding transcription factor activity
C0708_06195	COG2072	flavoprotein involved in K transport
C0708_06230	COG2197	response regulator
C0708_06235	COG0784	Response regulator, receiver
C0708_06235	COG2205	protein histidine kinase activity
C0708_06245	COG1129	ABC transporter
C0708_06260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0708_06270	COG3706	GGDEF domain
C0708_06270	COG0745	RESPONSE REGULATOR receiver
C0708_06280	COG2723	6-phospho-beta-galactosidase activity
C0708_06290	COG0583	DNA-binding transcription factor activity
C0708_06305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C0708_06310	COG0673	inositol 2-dehydrogenase activity
C0708_06315	COG0583	DNA-binding transcription factor activity
C0708_06325	COG1560	Kdo2-lipid A biosynthetic process
C0708_06330	COG1560	Kdo2-lipid A biosynthetic process
C0708_06375	COG0534	Mate efflux family protein
C0708_06385	COG0307	riboflavin synthase, alpha
C0708_06400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0708_06410	COG0697	spore germination
C0708_06415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C0708_06440	COG2996	Protein conserved in bacteria
C0708_06470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C0708_06475	COG2894	cell division
C0708_06480	COG0850	regulation of cytokinetic process
C0708_06485	COG3100	YcgL domain-containing protein
C0708_06500	COG1760	l-serine dehydratase
C0708_06510	COG1760	l-serine dehydratase
C0708_06515	COG3123	guanosine phosphorylase activity
C0708_06520	COG1301	dicarboxylic acid transport
C0708_06545	COG2067	long-chain fatty acid transport protein
C0708_06555	COG1595	DNA-templated transcription, initiation
C0708_06585	COG0714	Associated with various cellular activities
C0708_06590	COG0183	Belongs to the thiolase family
C0708_06595	COG1024	Enoyl-CoA hydratase
C0708_06595	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0708_06605	COG4681	YaeQ
C0708_06630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0708_06645	COG3134	Outer membrane lipoprotein
C0708_06650	COG0318	PFAM AMP-dependent synthetase and ligase
C0708_06655	COG2378	regulation of single-species biofilm formation
C0708_06665	COG0140	phosphoribosyl-ATP diphosphatase activity
C0708_06665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0708_06670	COG0107	imidazoleglycerol-phosphate synthase activity
C0708_06685	COG3437	response regulator, receiver
C0708_06690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0708_06695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0708_06700	COG0131	Imidazoleglycerol-phosphate dehydratase
C0708_06700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0708_06705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0708_06710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0708_06715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0708_06730	COG1214	PFAM Peptidase M22, glycoprotease
C0708_06740	COG0596	Alpha beta hydrolase
C0708_06775	COG2832	Protein of unknown function (DUF454)
C0708_06780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0708_06790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0708_06795	COG0583	DNA-binding transcription factor activity
C0708_06810	COG2197	response regulator
C0708_06820	COG1643	Atp-dependent helicase
C0708_06830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0708_06845	COG0675	Transposase, IS605 OrfB family
C0708_06860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0708_06865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C0708_06870	COG0709	Synthesizes selenophosphate from selenide and ATP
C0708_06885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0708_06895	COG1254	Belongs to the acylphosphatase family
C0708_06905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0708_06905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0708_06915	COG0572	uridine kinase
C0708_06920	COG0717	Belongs to the dCTP deaminase family
C0708_06925	COG0306	phosphate transporter
C0708_06930	COG1530	ribonuclease E activity
C0708_06935	COG0564	pseudouridine synthase activity
C0708_06950	COG1399	metal-binding, possibly nucleic acid-binding protein
C0708_06955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0708_06960	COG0416	fatty acid biosynthetic process
C0708_06965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0708_06975	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_06980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0708_06985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0708_06990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0708_06995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0708_07000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0708_07005	COG0470	DNA polymerase III
C0708_07010	COG0084	hydrolase, TatD family'
C0708_07025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C0708_07025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0708_07035	COG2995	paraquat-inducible protein a
C0708_07050	COG3141	response to X-ray
C0708_07060	COG1067	ATP-dependent peptidase activity
C0708_07065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0708_07090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0708_07090	COG0116	Belongs to the methyltransferase superfamily
C0708_07100	COG0167	dihydroorotate dehydrogenase activity
C0708_07105	COG2902	Dehydrogenase
C0708_07115	COG0308	aminopeptidase N
C0708_07125	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C0708_07130	COG1956	GAF domain-containing protein
C0708_07155	COG2010	Cytochrome c
C0708_07165	COG2217	Heavy metal translocating P-type atpase
C0708_07180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0708_07185	COG0589	response to stress
C0708_07190	COG0037	tRNA processing
C0708_07205	COG0675	Transposase, IS605 OrfB family
C0708_07215	COG0625	glutathione transferase activity
C0708_07220	COG1869	D-ribose catabolic process
C0708_07225	COG1129	ABC transporter
C0708_07230	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0708_07235	COG1879	ABC-type sugar transport system periplasmic component
C0708_07240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0708_07245	COG1609	Transcriptional regulator
C0708_07255	COG0675	Transposase, IS605 OrfB family
C0708_07270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0708_07290	COG0776	regulation of translation
C0708_07295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0708_07295	COG0072	phenylalanine-tRNA ligase activity
C0708_07300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0708_07305	COG4974	Belongs to the 'phage' integrase family
C0708_07315	COG3039	Transposase
C0708_07320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0708_07325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0708_07330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0708_07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0708_07370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0708_07375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0708_07380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0708_07385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C0708_07390	COG3313	Fe-S protein
C0708_07405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_07405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_07410	COG1609	Transcriptional regulator
C0708_07415	COG0814	amino acid
C0708_07430	COG0513	Belongs to the DEAD box helicase family
C0708_07445	COG2890	protein-(glutamine-N5) methyltransferase activity
C0708_07485	COG2824	Alkylphosphonate utilization operon protein PhnA
C0708_07515	COG0675	Transposase, IS605 OrfB family
C0708_07555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C0708_07560	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C0708_07575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C0708_07585	COG0205	6-phosphofructokinase activity
C0708_07615	COG1011	Hydrolase
C0708_07620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0708_07665	COG3593	DNA synthesis involved in DNA repair
C0708_07695	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0708_07710	COG0513	Belongs to the DEAD box helicase family
C0708_07725	COG1742	UPF0060 membrane protein
C0708_07755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0708_07775	COG3243	poly(R)-hydroxyalkanoic acid synthase
C0708_07785	COG2501	S4 domain
C0708_07815	COG3118	belongs to the thioredoxin family
C0708_07835	COG0058	SHG alpha-glucan phosphorylase activity
C0708_07865	COG0814	amino acid
C0708_07880	COG2766	serine protein kinase
C0708_07885	COG2718	Belongs to the UPF0229 family
C0708_07895	COG2186	Transcriptional regulator
C0708_07900	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0708_07905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0708_07910	COG0586	Pfam SNARE associated Golgi protein
C0708_07920	COG0556	nucleotide-excision repair
C0708_07935	COG0569	domain protein
C0708_07935	COG2985	domain, Protein
C0708_07940	COG0741	lytic transglycosylase activity
C0708_07940	COG0739	heme binding
C0708_07940	COG1196	nuclear chromosome segregation
C0708_07945	COG3181	Tripartite tricarboxylate transporter family receptor
C0708_07960	COG4565	transcriptional regulatory protein
C0708_07970	COG1940	carbohydrate kinase activity
C0708_07970	COG1846	Transcriptional regulator
C0708_07975	COG0840	transmembrane signaling receptor activity
C0708_07980	COG3012	SEC-C Motif Domain Protein
C0708_07985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0708_07990	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C0708_07995	COG0247	lactate metabolic process
C0708_08005	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C0708_08010	COG0437	4 iron, 4 sulfur cluster binding
C0708_08015	COG3301	Polysulphide reductase, NrfD
C0708_08020	COG1138	Cytochrome C-type biogenesis protein
C0708_08025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0708_08045	COG3046	protein related to deoxyribodipyrimidine photolyase
C0708_08050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0708_08055	COG0516	GMP reductase activity
C0708_08055	COG0517	IMP dehydrogenase activity
C0708_08065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0708_08070	COG0583	DNA-binding transcription factor activity
C0708_08080	COG4774	siderophore transport
C0708_08095	COG3706	GGDEF domain
C0708_08105	COG2203	Gaf domain
C0708_08105	COG5001	Diguanylate cyclase
C0708_08105	COG3706	GGDEF domain
C0708_08105	COG4251	negative regulation of phosphorylation
C0708_08110	COG2200	EAL domain
C0708_08115	COG4977	sequence-specific DNA binding
C0708_08115	COG1917	Cupin 2, conserved barrel domain protein
C0708_08120	COG0583	DNA-binding transcription factor activity
C0708_08125	COG2910	NAD(P)H-binding
C0708_08140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0708_08240	COG3039	Transposase
C0708_08285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0708_08290	COG0830	nickel cation binding
C0708_08300	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C0708_08310	COG0832	Belongs to the urease beta subunit family
C0708_08315	COG0831	urea catabolic process
C0708_08320	COG0829	nickel cation binding
C0708_08325	COG0410	ABC transporter
C0708_08330	COG0411	ABC transporter
C0708_08340	COG0559	Belongs to the binding-protein-dependent transport system permease family
C0708_08360	COG0745	RESPONSE REGULATOR receiver
C0708_08450	COG3039	Transposase
C0708_08480	COG2801	Transposase and inactivated derivatives
C0708_08510	COG3550	peptidyl-serine autophosphorylation
C0708_08540	COG2723	6-phospho-beta-galactosidase activity
C0708_08575	COG1435	thymidine kinase activity
C0708_08580	COG1757	Na H antiporter
C0708_08585	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0708_08590	COG2096	Adenosyltransferase
C0708_08595	COG3530	Putative quorum-sensing-regulated virulence factor
C0708_08600	COG0602	queuosine metabolic process
C0708_08605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0708_08625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C0708_08635	COG0776	regulation of translation
C0708_08640	COG0539	negative regulation of cytoplasmic translation
C0708_08645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0708_08650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0708_08680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C0708_08695	COG0583	DNA-binding transcription factor activity
C0708_08700	COG0745	RESPONSE REGULATOR receiver
C0708_08725	COG4989	oxidoreductase activity
C0708_08730	COG0724	RNA recognition motif
C0708_08740	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C0708_08750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C0708_08785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0708_08790	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_08795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0708_08800	COG1902	pentaerythritol trinitrate reductase activity
C0708_08805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0708_08815	COG4974	Belongs to the 'phage' integrase family
C0708_08870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0708_08895	COG4245	von Willebrand factor, type A
C0708_08920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0708_08925	COG1360	Flagellar Motor Protein
C0708_08930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0708_08935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0708_08955	COG1034	ATP synthesis coupled electron transport
C0708_08965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0708_08970	COG0839	Belongs to the complex I subunit 6 family
C0708_08975	COG0713	ATP synthesis coupled electron transport
C0708_08990	COG1007	ATP synthesis coupled electron transport
C0708_09005	COG1645	bacterial-type flagellum-dependent swarming motility
C0708_09010	COG1160	GTP binding
C0708_09015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0708_09020	COG2976	Protein conserved in bacteria
C0708_09025	COG0124	histidyl-tRNA synthetase
C0708_09035	COG1426	Protein conserved in bacteria
C0708_09045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0708_09050	COG0105	UTP biosynthetic process
C0708_09065	COG0633	Ferredoxin
C0708_09070	COG0443	Heat shock 70 kDa protein
C0708_09075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0708_09085	COG0822	iron-sulfur transferase activity
C0708_09090	COG1104	cysteine desulfurase activity
C0708_09125	COG2897	thiosulfate sulfurtransferase activity
C0708_09130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0708_09135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0708_09140	COG1862	Preprotein translocase
C0708_09145	COG0343	queuine tRNA-ribosyltransferase activity
C0708_09155	COG0517	IMP dehydrogenase activity
C0708_09160	COG0450	alkyl hydroperoxide reductase
C0708_09165	COG3634	alkyl hydroperoxide reductase activity
C0708_09190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0708_09190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0708_09195	COG0509	glycine decarboxylation via glycine cleavage system
C0708_09200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0708_09205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C0708_09230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0708_09250	COG2814	Major facilitator Superfamily
C0708_09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0708_09265	COG0601	transmembrane transport
C0708_09275	COG0625	glutathione transferase activity
C0708_09290	COG0483	inositol monophosphate 1-phosphatase activity
C0708_09305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0708_09310	COG2056	Na+-H+ antiporter family
C0708_09315	COG2814	Major facilitator Superfamily
C0708_09320	COG0583	DNA-binding transcription factor activity
C0708_09325	COG5001	Diguanylate cyclase
C0708_09340	COG2050	protein possibly involved in aromatic compounds catabolism
C0708_09360	COG3039	Transposase
C0708_09375	COG1253	flavin adenine dinucleotide binding
C0708_09380	COG1902	pentaerythritol trinitrate reductase activity
C0708_09395	COG0647	UMP catabolic process
C0708_09405	COG0367	asparagine synthase
C0708_09420	COG0625	glutathione transferase activity
C0708_09430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C0708_09445	COG0564	pseudouridine synthase activity
C0708_09495	COG0670	Belongs to the BI1 family
C0708_09500	COG1289	transmembrane transporter activity
C0708_09505	COG2920	part of a sulfur-relay system
C0708_09510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C0708_09520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0708_09525	COG0101	tRNA pseudouridine synthase activity
C0708_09535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0708_09540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0708_09550	COG1464	Belongs to the NlpA lipoprotein family
C0708_09580	COG1119	ATPase activity
C0708_09585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0708_09585	COG0574	Belongs to the PEP-utilizing enzyme family
C0708_09590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0708_09600	COG1113	amino acid transport
C0708_09660	COG0069	glutamate synthase activity
C0708_09660	COG0070	glutamate synthase
C0708_09660	COG0067	glutamate synthase
C0708_09665	COG0493	'glutamate synthase
C0708_09685	COG4104	PAAR repeat-containing protein
C0708_09695	COG0513	Belongs to the DEAD box helicase family
C0708_09730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0708_09745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0708_09750	COG0505	Belongs to the CarA family
C0708_09765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0708_09775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0708_09780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0708_09785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0708_09795	COG4139	cobalamin transport
C0708_09830	COG0023	Translation Initiation Factor
C0708_09835	COG2119	membrane
C0708_09870	COG2199	diguanylate cyclase activity
C0708_09870	COG2203	Gaf domain
C0708_09890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0708_09905	COG2261	transglycosylase associated protein
C0708_09910	COG1309	transcriptional regulator
C0708_09915	COG0604	alcohol dehydrogenase
C0708_09930	COG3039	Transposase
C0708_09980	COG0582	viral genome integration into host DNA
C0708_10005	COG0322	excinuclease ABC activity
C0708_10010	COG2197	response regulator
C0708_10015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C0708_10020	COG2835	tetraacyldisaccharide 4'-kinase activity
C0708_10025	COG1663	tetraacyldisaccharide 4'-kinase activity
C0708_10030	COG1132	(ABC) transporter
C0708_10035	COG2333	competence protein COMEC
C0708_10035	COG0658	competence protein
C0708_10050	COG0433	COG0433 Predicted ATPase
C0708_10055	COG1448	Aminotransferase
C0708_10070	COG1199	ATP-dependent helicase activity
C0708_10080	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0708_10085	COG0477	Major facilitator Superfamily
C0708_10095	COG1785	Belongs to the alkaline phosphatase family
C0708_10125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_10130	COG0765	amino acid transport
C0708_10145	COG0531	amino acid
C0708_10160	COG1253	flavin adenine dinucleotide binding
C0708_10165	COG0704	Plays a role in the regulation of phosphate uptake
C0708_10175	COG0581	inorganic phosphate transmembrane transporter activity
C0708_10180	COG0573	inorganic phosphate transmembrane transporter activity
C0708_10185	COG0590	tRNA wobble adenosine to inosine editing
C0708_10200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0708_10220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0708_10225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0708_10230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0708_10235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0708_10240	COG2204	response regulator
C0708_10245	COG3852	Histidine kinase
C0708_10250	COG2204	response regulator
C0708_10260	COG2716	regulation of RNA biosynthetic process
C0708_10265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0708_10270	COG0248	Ppx GppA phosphatase
C0708_10280	COG0675	Transposase, IS605 OrfB family
C0708_10325	COG1705	Flagellar rod assembly protein muramidase FlgJ
C0708_10325	COG3951	Flagellar rod assembly protein muramidase FlgJ
C0708_10330	COG1706	bacterial-type flagellum-dependent cell motility
C0708_10335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C0708_10340	COG4786	Flagellar basal body rod
C0708_10350	COG4786	Flagellar basal body rod
C0708_10360	COG1558	bacterial-type flagellum-dependent cell motility
C0708_10365	COG1815	bacterial-type flagellum-dependent cell motility
C0708_10370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0708_10375	COG0784	Response regulator, receiver
C0708_10375	COG0835	chemotaxis
C0708_10380	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C0708_10395	COG0622	Phosphoesterase
C0708_10420	COG1187	pseudouridine synthase activity
C0708_10425	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0708_10430	COG0675	Transposase, IS605 OrfB family
C0708_10440	COG0697	spore germination
C0708_10480	COG1278	Cold shock
C0708_10490	COG0675	Transposase, IS605 OrfB family
C0708_10505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0708_10530	COG3132	Protein of unknown function, DUF480
C0708_10540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0708_10560	COG0489	protein tyrosine kinase activity
C0708_10560	COG3206	protein involved in exopolysaccharide biosynthesis
C0708_10565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0708_10615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0708_10640	COG0438	transferase activity, transferring glycosyl groups
C0708_10675	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C0708_10685	COG0745	RESPONSE REGULATOR receiver
C0708_10700	COG1737	Transcriptional regulator
C0708_10705	COG0469	pyruvate kinase activity
C0708_10720	COG1960	acyl-CoA dehydrogenase activity
C0708_10750	COG1484	DNA-dependent DNA replication
C0708_10755	COG4584	PFAM Integrase catalytic
C0708_10770	COG0583	DNA-binding transcription factor activity
C0708_10785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0708_10870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0708_10880	COG1309	transcriptional regulator
C0708_10895	COG1946	Acyl-CoA thioesterase
C0708_10920	COG0009	L-threonylcarbamoyladenylate synthase
C0708_10930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0708_10935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0708_10935	COG0512	Glutamine amidotransferase of anthranilate synthase
C0708_10940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0708_10950	COG0133	tryptophan synthase activity
C0708_10960	COG1396	sequence-specific DNA binding
C0708_10965	COG3550	peptidyl-serine autophosphorylation
C0708_11000	COG5507	3-demethylubiquinone-9 3-methyltransferase
C0708_11005	COG2814	Major facilitator Superfamily
C0708_11015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C0708_11020	COG1845	cytochrome c oxidase, subunit III
C0708_11025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0708_11030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0708_11035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0708_11040	COG0583	DNA-binding transcription factor activity
C0708_11060	COG1846	Transcriptional regulator
C0708_11100	COG0708	Exodeoxyribonuclease III
C0708_11110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_11115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0708_11130	COG0095	Lipoate-protein ligase
C0708_11150	COG2391	methyltransferase activity
C0708_11160	COG0640	Transcriptional regulator
C0708_11170	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0708_11180	COG1285	pathogenesis
C0708_11210	COG0484	heat shock protein binding
C0708_11215	COG0443	Heat shock 70 kDa protein
C0708_11220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0708_11225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0708_11235	COG0497	DNA recombination
C0708_11245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_11250	COG0577	efflux transmembrane transporter activity
C0708_11250	COG1136	(ABC) transporter
C0708_11255	COG1538	Outer membrane efflux protein
C0708_11260	COG2375	cellular response to nickel ion
C0708_11275	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0708_11280	COG0583	DNA-binding transcription factor activity
C0708_11285	COG3048	D-serine ammonia-lyase activity
C0708_11295	COG0538	isocitrate dehydrogenase activity
C0708_11325	COG0456	acetyltransferase
C0708_11330	COG1187	pseudouridine synthase activity
C0708_11340	COG0482	sulfurtransferase activity
C0708_11345	COG2915	High frequency lysogenization protein hflD homolog
C0708_11350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0708_11355	COG2850	peptidyl-arginine hydroxylation
C0708_11365	COG3264	Mechanosensitive ion channel
C0708_11365	COG1196	nuclear chromosome segregation
C0708_11375	COG2706	6-phosphogluconolactonase activity
C0708_11400	COG0746	molybdenum cofactor guanylyltransferase activity
C0708_11405	COG1763	Mo-molybdopterin cofactor biosynthetic process
C0708_11410	COG1289	transmembrane transporter activity
C0708_11415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0708_11445	COG3220	belongs to the UPF0276 family
C0708_11460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0708_11470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0708_11505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0708_11510	COG0083	homoserine kinase activity
C0708_11525	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C0708_11545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0708_11555	COG0745	RESPONSE REGULATOR receiver
C0708_11570	COG4988	ABC transporter
C0708_11575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0708_11595	COG1720	tRNA m6t6A37 methyltransferase activity
C0708_11610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0708_11615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0708_11620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_11630	COG2190	(PTS) system
C0708_11645	COG0420	3'-5' exonuclease activity
C0708_11655	COG2974	May be involved in recombination
C0708_11670	COG4651	solute:proton antiporter activity
C0708_11670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0708_11710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0708_11715	COG1396	sequence-specific DNA binding
C0708_11715	COG1917	Cupin 2, conserved barrel domain protein
C0708_11720	COG1012	belongs to the aldehyde dehydrogenase family
C0708_11735	COG0531	amino acid
C0708_11740	COG0531	amino acid
C0708_11760	COG3384	dioxygenase
C0708_11790	COG2205	protein histidine kinase activity
C0708_11790	COG0784	Response regulator, receiver
C0708_11815	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C0708_11820	COG0791	NLP P60 protein
C0708_11830	COG3118	belongs to the thioredoxin family
C0708_11840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0708_11845	COG0788	formyltetrahydrofolate deformylase activity
C0708_11870	COG0739	heme binding
C0708_11870	COG1196	nuclear chromosome segregation
C0708_11870	COG0741	lytic transglycosylase activity
C0708_11885	COG0673	inositol 2-dehydrogenase activity
C0708_11915	COG1032	radical SAM domain protein
C0708_11970	COG0281	malic enzyme
C0708_11975	COG2207	Transcriptional regulator
C0708_11990	COG0745	RESPONSE REGULATOR receiver
C0708_11990	COG3706	GGDEF domain
C0708_12000	COG2233	PERMEase
C0708_12005	COG0095	Lipoate-protein ligase
C0708_12010	COG1115	amino acid carrier protein
C0708_12015	COG0019	diaminopimelate decarboxylase activity
C0708_12025	COG0678	peroxiredoxin activity
C0708_12030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0708_12040	COG1126	abc transporter atp-binding protein
C0708_12045	COG0765	amino acid transport
C0708_12050	COG4597	amino acid ABC transporter
C0708_12055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_12075	COG0545	Peptidyl-prolyl cis-trans isomerase
C0708_12080	COG3142	Participates in the control of copper homeostasis
C0708_12095	COG4783	chaperone-mediated protein folding
C0708_12105	COG5002	protein histidine kinase activity
C0708_12110	COG0745	RESPONSE REGULATOR receiver
C0708_12125	COG3284	Transcriptional regulator
C0708_12130	COG1012	belongs to the aldehyde dehydrogenase family
C0708_12140	COG0697	spore germination
C0708_12145	COG0667	Aldo Keto reductase
C0708_12155	COG3385	transposase activity
C0708_12175	COG1566	PFAM secretion protein HlyD family protein
C0708_12200	COG0602	queuosine metabolic process
C0708_12205	COG1328	CTP reductase activity
C0708_12215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0708_12220	COG3115	cell septum assembly
C0708_12245	COG3108	Peptidase M15
C0708_12250	COG3385	transposase activity
C0708_12255	COG2989	Protein conserved in bacteria
C0708_12270	COG0463	Glycosyl transferase, family 2
C0708_12285	COG0366	Alpha amylase catalytic
C0708_12330	COG3706	GGDEF domain
C0708_12335	COG0037	tRNA processing
C0708_12360	COG0531	amino acid
C0708_12365	COG0814	amino acid
C0708_12380	COG0825	malonyl-CoA metabolic process
C0708_12390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0708_12400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0708_12405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0708_12410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0708_12425	COG0750	zinc metalloprotease
C0708_12435	COG0575	Belongs to the CDS family
C0708_12445	COG0233	cytoplasmic translational termination
C0708_12450	COG0528	UMP kinase activity
C0708_12455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0708_12460	COG0052	Belongs to the universal ribosomal protein uS2 family
C0708_12465	COG0024	Methionine aminopeptidase
C0708_12470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0708_12475	COG2171	N-acyltransferase activity
C0708_12485	COG1263	PTS System
C0708_12485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0708_12495	COG4580	involved in the transport of maltose and maltodextrins
C0708_12510	COG3098	single-species biofilm formation
C0708_12535	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C0708_12555	COG3706	GGDEF domain
C0708_12565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0708_12570	COG0473	3-isopropylmalate dehydrogenase activity
C0708_12580	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C0708_12595	COG0583	DNA-binding transcription factor activity
C0708_12600	COG0840	transmembrane signaling receptor activity
C0708_12605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0708_12620	COG1477	protein flavinylation
C0708_12625	COG2871	sodium ion transport
C0708_12630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0708_12635	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0708_12640	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0708_12645	COG1805	sodium ion transport
C0708_12650	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0708_12655	COG0271	Belongs to the BolA IbaG family
C0708_12660	COG2813	Specifically methylates the guanine in position
C0708_12670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0708_12680	COG2211	Major facilitator Superfamily
C0708_12685	COG3248	Nucleoside-binding outer membrane protein
C0708_12690	COG1666	GTP binding
C0708_12695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0708_12705	COG0659	secondary active sulfate transmembrane transporter activity
C0708_12710	COG5002	protein histidine kinase activity
C0708_12710	COG5000	phosphorelay sensor kinase activity
C0708_12720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_12725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0708_12745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0708_12755	COG1151	hydroxylamine reductase activity
C0708_12760	COG0783	Belongs to the Dps family
C0708_12800	COG4221	oxidoreductase activity
C0708_12810	COG0415	Belongs to the DNA photolyase family
C0708_12815	COG0789	Transcriptional regulator
C0708_12820	COG3272	Protein of unknown function (DUF1722)
C0708_12845	COG1605	Chorismate mutase
C0708_12845	COG0077	Prephenate dehydratase
C0708_12875	COG2133	pyrroloquinoline quinone binding
C0708_12890	COG2084	Dehydrogenase
C0708_12905	COG3622	Belongs to the hyi family
C0708_12915	COG2610	gluconate transmembrane transporter activity
C0708_12935	COG0300	oxidoreductase activity
C0708_12980	COG3813	Protein conserved in bacteria
C0708_12995	COG1280	lysine exporter protein (LysE YggA)
C0708_13045	COG3279	Response regulator of the LytR AlgR family
C0708_13050	COG1966	Carbon starvation protein
C0708_13060	COG0114	fumarate hydratase activity
C0708_13075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0708_13080	COG0305	Participates in initiation and elongation during chromosome replication
C0708_13090	COG0737	Belongs to the 5'-nucleotidase family
C0708_13110	COG2204	response regulator
C0708_13115	COG0545	Peptidyl-prolyl cis-trans isomerase
C0708_13125	COG2900	Belongs to the SlyX family
C0708_13130	COG1047	Peptidyl-prolyl cis-trans
C0708_13135	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C0708_13145	COG0835	chemotaxis
C0708_13145	COG0784	Response regulator, receiver
C0708_13150	COG0429	hydrolase of the alpha beta-hydrolase fold
C0708_13155	COG4251	negative regulation of phosphorylation
C0708_13155	COG2203	Gaf domain
C0708_13155	COG3706	GGDEF domain
C0708_13155	COG5001	Diguanylate cyclase
C0708_13160	COG3089	Belongs to the UPF0270 family
C0708_13165	COG3954	Phosphoribulokinase
C0708_13180	COG1765	OsmC-like protein
C0708_13185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0708_13190	COG2226	methyltransferase
C0708_13235	COG3721	Heme iron utilization protein
C0708_13290	COG0741	lytic transglycosylase activity
C0708_13295	COG0488	(ABC) transporter
C0708_13305	COG2252	PERMEase
C0708_13310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0708_13315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0708_13320	COG3178	'Phosphotransferase
C0708_13340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0708_13350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0708_13375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0708_13380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0708_13385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0708_13390	COG0142	geranyltranstransferase activity
C0708_13395	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C0708_13400	COG0330	HflC and HflK could
C0708_13410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0708_13415	COG1923	regulation of RNA biosynthetic process
C0708_13425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0708_13435	COG0802	atpase or kinase
C0708_13440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0708_13440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0708_13460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0708_13465	COG2011	ABC-type metal ion transport system permease component
C0708_13470	COG1464	Belongs to the NlpA lipoprotein family
C0708_13505	COG2198	Histidine kinase
C0708_13505	COG0784	Response regulator, receiver
C0708_13505	COG5002	protein histidine kinase activity
C0708_13525	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C0708_13540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0708_13545	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C0708_13550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0708_13555	COG2716	regulation of RNA biosynthetic process
C0708_13560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0708_13565	COG3013	Belongs to the UPF0304 family
C0708_13570	COG3092	negative regulation of chromosome organization
C0708_13575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0708_13580	COG0280	phosphate acetyltransferase
C0708_13580	COG0857	belongs to the CobB CobQ family
C0708_13585	COG0440	acetolactate synthase activity
C0708_13590	COG0028	Belongs to the TPP enzyme family
C0708_13615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0708_13620	COG0473	3-isopropylmalate dehydrogenase activity
C0708_13625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0708_13630	COG0066	3-isopropylmalate dehydratase activity
C0708_13645	COG4143	(ABC) transporter
C0708_13655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C0708_13660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0708_13715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0708_13730	COG0671	phosphoesterase, PA-phosphatase related
C0708_13740	COG0583	DNA-binding transcription factor activity
C0708_13745	COG2076	Multidrug Resistance protein
C0708_13755	COG0346	lactoylglutathione lyase activity
C0708_13760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0708_13765	COG1643	Atp-dependent helicase
C0708_13775	COG1489	DNA binding
C0708_13780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0708_13785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0708_13795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0708_13800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0708_13815	COG0842	Transport permease protein
C0708_13820	COG1131	(ABC) transporter
C0708_13835	COG0163	prenyltransferase activity
C0708_13840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0708_13845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0708_13860	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C0708_13875	COG1136	(ABC) transporter
C0708_13915	COG0529	Catalyzes the synthesis of activated sulfate
C0708_13920	COG3273	potassium ion transport
C0708_13920	COG0471	metal ion transport
C0708_13925	COG2895	sulfate adenylyltransferase (ATP) activity
C0708_13930	COG0175	sulfate reduction
C0708_13935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0708_13935	COG1648	precorrin-2 dehydrogenase activity
C0708_13940	COG0330	HflC and HflK could
C0708_13945	COG1585	Membrane protein implicated in regulation of membrane protease activity
C0708_13955	COG0673	inositol 2-dehydrogenase activity
C0708_13965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0708_13970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0708_13980	COG3036	rescue of stalled ribosome
C0708_13995	COG0138	bifunctional purine biosynthesis protein purh
C0708_14000	COG0151	Belongs to the GarS family
C0708_14035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0708_14040	COG0358	DNA primase activity
C0708_14045	COG1610	YqeY-like protein
C0708_14050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C0708_14055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0708_14070	COG1238	metal cluster binding
C0708_14075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0708_14085	COG0585	pseudouridine synthase activity
C0708_14095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0708_14100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0708_14105	COG0148	phosphopyruvate hydratase activity
C0708_14110	COG0504	CTP synthase activity
C0708_14115	COG3956	TIGRFAM MazG family protein
C0708_14120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0708_14125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0708_14135	COG4807	Protein conserved in bacteria
C0708_14140	COG3023	N-Acetylmuramoyl-L-alanine amidase
C0708_14145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0708_14150	COG1381	Involved in DNA repair and RecF pathway recombination
C0708_14160	COG0571	ribonuclease III activity
C0708_14165	COG0681	Belongs to the peptidase S26 family
C0708_14170	COG0481	GTPase activity
C0708_14185	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C0708_14190	COG1595	DNA-templated transcription, initiation
C0708_14195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0708_14205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C0708_14220	COG0583	DNA-binding transcription factor activity
C0708_14260	COG0126	phosphoglycerate kinase activity
C0708_14265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0708_14270	COG1940	carbohydrate kinase activity
C0708_14275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0708_14280	COG2816	NAD+ diphosphatase activity
C0708_14290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0708_14305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0708_14310	COG1028	Short-chain dehydrogenase reductase Sdr
C0708_14320	COG1505	serine-type exopeptidase activity
C0708_14325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0708_14330	COG0765	amino acid transport
C0708_14335	COG0765	amino acid transport
C0708_14340	COG1126	abc transporter atp-binding protein
C0708_14345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_14350	COG3174	membrane
C0708_14355	COG0110	maltose O-acetyltransferase activity
C0708_14385	COG1942	4-Oxalocrotonate Tautomerase
C0708_14395	COG0583	DNA-binding transcription factor activity
C0708_14400	COG0165	Argininosuccinate lyase
C0708_14410	COG0137	argininosuccinate synthase activity
C0708_14420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0708_14425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0708_14435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C0708_14440	COG5002	protein histidine kinase activity
C0708_14440	COG3447	MASE1 domain protein
C0708_14440	COG5001	Diguanylate cyclase
C0708_14445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0708_14480	COG0583	DNA-binding transcription factor activity
C0708_14485	COG1380	Effector of murein hydrolase LrgA
C0708_14490	COG1346	cytolysis
C0708_14495	COG0527	aspartate kinase activity
C0708_14495	COG0460	homoserine dehydrogenase
C0708_14525	COG1218	3'(2'),5'-bisphosphate nucleotidase
C0708_14530	COG0494	nUDIX hydrolase
C0708_14535	COG1011	Hydrolase
C0708_14550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0708_14565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C0708_14575	COG3156	type II secretion system protein K
C0708_14580	COG4795	General secretion pathway protein
C0708_14585	COG2165	general secretion pathway protein
C0708_14595	COG2165	general secretion pathway protein
C0708_14600	COG1459	type II secretion system
C0708_14605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0708_14615	COG3031	protein transport across the cell outer membrane
C0708_14625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0708_14630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C0708_14650	COG3133	Outer membrane lipoprotein
C0708_14655	COG3025	triphosphatase activity
C0708_14660	COG1392	Phosphate transport regulator
C0708_14665	COG0306	phosphate transporter
C0708_14670	COG0617	tRNA 3'-terminal CCA addition
C0708_14675	COG3267	Type II secretory pathway component ExeA
C0708_14675	COG3409	Peptidoglycan-binding domain 1 protein
C0708_14685	COG1194	a g-specific adenine glycosylase
C0708_14690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C0708_14705	COG3240	lipase activity
C0708_14715	COG3009	Protein conserved in bacteria
C0708_14720	COG3008	intermembrane lipid transfer
C0708_14720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0708_14725	COG2995	paraquat-inducible protein a
C0708_14735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0708_14745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0708_14755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0708_14760	COG0297	glycogen (starch) synthase activity
C0708_14800	COG1757	Na H antiporter
C0708_14805	COG0583	DNA-binding transcription factor activity
C0708_14810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C0708_14820	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0708_14825	COG1177	transmembrane transport
C0708_14830	COG1012	belongs to the aldehyde dehydrogenase family
C0708_14835	COG0109	protoheme IX farnesyltransferase activity
C0708_14860	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C0708_14870	COG1565	acr, cog1565
C0708_14870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0708_14875	COG1444	tRNA N-acetyltransferase activity
C0708_14895	COG1803	Methylglyoxal synthase
C0708_14910	COG0252	asparaginase activity
C0708_14930	COG1263	PTS System
C0708_14930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0708_14935	COG0366	Alpha amylase catalytic
C0708_14940	COG0110	maltose O-acetyltransferase activity
C0708_14945	COG1522	sequence-specific DNA binding
C0708_14950	COG5006	permease, DMT superfamily
C0708_14975	COG3068	Protein conserved in bacteria
C0708_14985	COG0739	heme binding
C0708_15005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C0708_15010	COG1121	(ABC) transporter
C0708_15015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0708_15030	COG1573	uracil-dna glycosylase
C0708_15040	COG2827	Endonuclease containing a URI domain
C0708_15055	COG1842	Phage shock protein A
C0708_15085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0708_15150	COG1289	transmembrane transporter activity
C0708_15155	COG1566	PFAM secretion protein HlyD family protein
C0708_15175	COG3150	esterase
C0708_15185	COG3151	Protein conserved in bacteria
C0708_15190	COG0494	nUDIX hydrolase
C0708_15195	COG1538	Outer membrane efflux protein
C0708_15205	COG1560	Kdo2-lipid A biosynthetic process
C0708_15220	COG2771	luxR family
C0708_15235	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C0708_15240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_15240	COG2213	PTS system mannitol-specific
C0708_15245	COG0246	Mannitol dehydrogenase
C0708_15250	COG3722	fumarate hydratase activity
C0708_15290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0708_15295	COG0513	Belongs to the DEAD box helicase family
C0708_15325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0708_15330	COG0596	Alpha beta hydrolase
C0708_15335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0708_15350	COG3291	Pkd domain containing protein
C0708_15355	COG2949	membrane
C0708_15370	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C0708_15400	COG2873	o-acetylhomoserine
C0708_15425	COG4221	oxidoreductase activity
C0708_15445	COG1285	pathogenesis
C0708_15460	COG1368	sulfuric ester hydrolase activity
C0708_15465	COG1522	sequence-specific DNA binding
C0708_15475	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C0708_15485	COG1546	Belongs to the CinA family
C0708_15485	COG1058	Belongs to the CinA family
C0708_15490	COG1988	membrane-bound metal-dependent
C0708_15505	COG0561	phosphatase activity
C0708_15510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0708_15520	COG1011	Hydrolase
C0708_15535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0708_15540	COG0019	diaminopimelate decarboxylase activity
C0708_15550	COG1965	Belongs to the frataxin family
C0708_15555	COG0400	carboxylic ester hydrolase activity
C0708_15560	COG3072	Adenylate cyclase
C0708_15565	COG0181	hydroxymethylbilane synthase activity
C0708_15575	COG2959	enzyme of heme biosynthesis
C0708_15580	COG3071	HemY protein
C0708_15585	COG0312	modulator of DNA gyrase
C0708_15590	COG3028	Belongs to the UPF0307 family
C0708_15600	COG2926	Belongs to the UPF0265 family
C0708_15630	COG1396	sequence-specific DNA binding
C0708_15635	COG3135	benzoate transporter
C0708_15665	COG3047	cAMP biosynthetic process
C0708_15700	COG1278	Cold shock
C0708_15705	COG3385	transposase activity
C0708_15715	COG0745	RESPONSE REGULATOR receiver
C0708_15735	COG3706	GGDEF domain
C0708_15740	COG0347	Belongs to the P(II) protein family
C0708_15745	COG0004	ammonium transporteR
C0708_15770	COG2259	Doxx family
C0708_15785	COG0583	DNA-binding transcription factor activity
C0708_15820	COG3842	ATPase activity
C0708_15830	COG3706	GGDEF domain
C0708_15830	COG0745	RESPONSE REGULATOR receiver
C0708_15850	COG0456	acetyltransferase
C0708_15855	COG0753	catalase activity
C0708_15875	COG0494	nUDIX hydrolase
C0708_15890	COG2957	Belongs to the agmatine deiminase family
C0708_15905	COG2957	Belongs to the agmatine deiminase family
C0708_15910	COG0583	DNA-binding transcription factor activity
C0708_15925	COG1461	Dihydroxyacetone kinase
C0708_15930	COG2376	Dihydroxyacetone kinase
C0708_15935	COG2252	PERMEase
C0708_15940	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C0708_15975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0708_15980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0708_15985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0708_15990	COG0049	tRNA binding
C0708_15995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0708_16000	COG2168	tRNA wobble position uridine thiolation
C0708_16010	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0708_16015	COG0251	oxidation-reduction process
C0708_16020	COG2964	Protein conserved in bacteria
C0708_16025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0708_16030	COG0085	RNA polymerase activity
C0708_16035	COG0222	ribosome binding
C0708_16040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0708_16045	COG0081	regulation of translation
C0708_16050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0708_16055	COG0250	Participates in transcription elongation, termination and antitermination
C0708_16060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0708_16070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0708_16095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0708_16100	COG0569	domain protein
C0708_16105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0708_16115	COG3005	denitrification pathway
C0708_16120	COG0243	molybdopterin cofactor binding
C0708_16135	COG0745	RESPONSE REGULATOR receiver
C0708_16170	COG2204	response regulator
C0708_16200	COG0517	IMP dehydrogenase activity
C0708_16200	COG0516	GMP reductase activity
C0708_16210	COG1522	sequence-specific DNA binding
C0708_16215	COG2502	aspartate--ammonia ligase
C0708_16220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0708_16225	COG0542	response to heat
C0708_16235	COG0564	pseudouridine synthase activity
C0708_16240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0708_16245	COG3681	Belongs to the UPF0597 family
C0708_16250	COG2964	Protein conserved in bacteria
C0708_16255	COG3385	transposase activity
C0708_16260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C0708_16265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0708_16270	COG1979	alcohol dehydrogenase
C0708_16280	COG3040	lipid binding
C0708_16325	COG1438	arginine binding
C0708_16330	COG1288	antiporter activity
C0708_16335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0708_16380	COG1609	Transcriptional regulator
C0708_16395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0708_16400	COG2017	converts alpha-aldose to the beta-anomer
C0708_16410	COG1968	undecaprenyl-diphosphatase activity
C0708_16415	COG3806	Anti-sigma factor
C0708_16420	COG1595	DNA-templated transcription, initiation
C0708_16440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0708_16445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C0708_16465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_16470	COG1131	(ABC) transporter
C0708_16475	COG0842	Transport permease protein
C0708_16480	COG0842	Transport permease protein
C0708_16485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0708_16490	COG2146	nitrite reductase [NAD(P)H] activity
C0708_16495	COG2116	formate transmembrane transporter activity
C0708_16500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0708_16500	COG1648	precorrin-2 dehydrogenase activity
C0708_16510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0708_16515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C0708_16525	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0708_16540	COG2050	protein possibly involved in aromatic compounds catabolism
C0708_16555	COG2258	MOSC domain
C0708_16560	COG1177	transmembrane transport
C0708_16565	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0708_16570	COG3842	ATPase activity
C0708_16590	COG0174	glutamine synthetase
C0708_16595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0708_16610	COG3045	CreA protein
C0708_16615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0708_16620	COG0443	Heat shock 70 kDa protein
C0708_16635	COG0366	Alpha amylase catalytic
C0708_16645	COG4310	Domain of unknown function (DUF2172)
C0708_16680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0708_16695	COG2205	protein histidine kinase activity
C0708_16710	COG0702	epimerase
C0708_16715	COG0254	rRNA binding
C0708_16725	COG1309	transcriptional regulator
C0708_16735	COG3385	transposase activity
C0708_16750	COG0129	dihydroxy-acid dehydratase activity
C0708_16755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0708_16760	COG3978	acetolactate synthase activity
C0708_16775	COG0606	chelatase, subunit chli
C0708_16785	COG0204	Acyl-transferase
C0708_16790	COG1683	Conserved Protein
C0708_16800	COG1335	isochorismatase
C0708_16810	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C0708_16815	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C0708_16820	COG3639	organic phosphonate transmembrane transporter activity
C0708_16825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0708_16830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0708_16840	COG3084	Protein conserved in bacteria
C0708_16845	COG4251	negative regulation of phosphorylation
C0708_16845	COG2203	Gaf domain
C0708_16845	COG3706	GGDEF domain
C0708_16845	COG5001	Diguanylate cyclase
C0708_16860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0708_16865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0708_16870	COG1561	YicC-like family, N-terminal region
C0708_16935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0708_16955	COG1857	crispr-associated protein
C0708_16995	COG0859	PFAM glycosyl transferase family 9
C0708_17005	COG0859	PFAM glycosyl transferase family 9
C0708_17010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0708_17015	COG2990	Protein conserved in bacteria
C0708_17030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0708_17035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0708_17040	COG2003	Belongs to the UPF0758 family
C0708_17045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0708_17050	COG0756	dUTP diphosphatase activity
C0708_17055	COG1309	transcriptional regulator
C0708_17070	COG0668	transmembrane transport
C0708_17080	COG0166	Belongs to the GPI family
C0708_17085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0708_17090	COG0583	DNA-binding transcription factor activity
C0708_17100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0708_17100	COG1042	CoA-binding domain protein
C0708_17100	COG0045	succinate-CoA ligase (ADP-forming) activity
C0708_17125	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C0708_17130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0708_17140	COG0006	proline dipeptidase activity
C0708_17145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0708_17150	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0708_17150	COG1024	Enoyl-CoA hydratase
C0708_17155	COG0183	Belongs to the thiolase family
C0708_17160	COG0745	RESPONSE REGULATOR receiver
C0708_17165	COG2205	protein histidine kinase activity
C0708_17195	COG0425	Belongs to the sulfur carrier protein TusA family
C0708_17200	COG0251	oxidation-reduction process
C0708_17215	COG2885	chlorophyll binding
C0708_17225	COG1335	isochorismatase
C0708_17230	COG2818	Glycosylase
C0708_17235	COG0752	glycyl-tRNA synthetase alpha subunit
C0708_17240	COG0751	glycine-tRNA ligase activity
C0708_17285	COG0348	domain, Protein
C0708_17295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0708_17300	COG1773	rubredoxin
C0708_17300	COG0426	domain, Protein
C0708_17305	COG3604	Transcriptional regulator
C0708_17310	COG1609	Transcriptional regulator
C0708_17320	COG0559	Belongs to the binding-protein-dependent transport system permease family
C0708_17350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0708_17365	COG2960	long-chain fatty acid transporting porin activity
C0708_17385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0708_17390	COG3118	belongs to the thioredoxin family
C0708_17400	COG0248	Ppx GppA phosphatase
C0708_17415	COG0742	ribosomal rna small subunit methyltransferase
C0708_17440	COG0805	protein transport
C0708_17445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0708_17450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0708_17455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0708_17460	COG3165	ubiquinone biosynthetic process from chorismate
C0708_17470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0708_17475	COG0402	S-adenosylhomocysteine deaminase activity
C0708_17510	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C0708_17515	COG0848	biopolymer transport protein
C0708_17520	COG0811	peptide transport
C0708_17525	COG0811	peptide transport
C0708_17535	COG2771	luxR family
C0708_17540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0708_17545	COG0501	Belongs to the peptidase M48B family
C0708_17565	COG0542	response to heat
C0708_17570	COG0071	Belongs to the small heat shock protein (HSP20) family
C0708_17675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0708_17680	COG1349	DNA-binding transcription factor activity
C0708_17685	COG0745	RESPONSE REGULATOR receiver
C0708_17690	COG2205	protein histidine kinase activity
C0708_17700	COG4452	Inner membrane protein CreD
C0708_17705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0708_17710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0708_17715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0708_17720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0708_17725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0708_17730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0708_17735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0708_17745	COG0356	it plays a direct role in the translocation of protons across the membrane
C0708_17755	COG1475	DNA binding
C0708_17760	COG1192	Involved in chromosome partitioning
C0708_17765	COG0357	Ribosomal RNA small subunit methyltransferase G
C0708_17770	COG0445	tRNA wobble uridine modification
C0708_17775	COG0716	FMN binding
C0708_17780	COG4774	siderophore transport
C0708_17790	COG1120	ATPase activity
C0708_17805	COG3385	transposase activity
C0708_17810	COG3550	peptidyl-serine autophosphorylation
C0708_17860	COG4974	Belongs to the 'phage' integrase family
C0708_17865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0708_17870	COG0706	membrane insertase activity
C0708_17875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0708_17880	COG0594	ribonuclease P activity
C0708_17885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C0708_17905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0708_17910	COG0592	DNA-directed DNA polymerase activity
C0708_17920	COG0187	DNA topoisomerase II activity
C0708_17925	COG2801	Transposase and inactivated derivatives
C0708_17930	COG2207	Transcriptional regulator
C0708_17935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0708_17945	COG0071	Belongs to the small heat shock protein (HSP20) family
C0708_17950	COG3977	Valine--pyruvate aminotransferase
C0708_17970	COG0745	RESPONSE REGULATOR receiver
C0708_18000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0708_18005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_18005	COG4191	Histidine kinase
C0708_18010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0708_18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_18020	COG1309	transcriptional regulator
C0708_18050	COG0561	phosphatase activity
C0708_18060	COG0110	maltose O-acetyltransferase activity
C0708_18065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0708_18070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0708_18075	COG1758	RNA polymerase activity
C0708_18135	COG0589	response to stress
C0708_18140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0708_18145	COG3706	GGDEF domain
C0708_18150	COG1528	Iron-storage protein
C0708_18160	COG2223	nitrite transmembrane transporter activity
C0708_18165	COG1280	lysine exporter protein (LysE YggA)
C0708_18180	COG3039	Transposase
C0708_18200	COG3275	phosphorelay sensor kinase activity
C0708_18205	COG3279	Response regulator of the LytR AlgR family
C0708_18210	COG2223	nitrite transmembrane transporter activity
C0708_18215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0708_18220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0708_18275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0708_18280	COG2166	iron-sulfur cluster assembly
C0708_18285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0708_18305	COG1063	alcohol dehydrogenase
C0708_18310	COG0156	8-amino-7-oxononanoate synthase activity
C0708_18320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0708_18395	COG1580	Controls the rotational direction of flagella during chemotaxis
C0708_18400	COG3161	chorismate lyase activity
C0708_18405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0708_18410	COG2937	Belongs to the GPAT DAPAT family
C0708_18415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0708_18430	COG0534	Mate efflux family protein
C0708_18435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0708_18440	COG2205	protein histidine kinase activity
C0708_18445	COG0745	RESPONSE REGULATOR receiver
C0708_18455	COG1045	serine acetyltransferase
C0708_18465	COG3074	FtsZ-dependent cytokinesis
C0708_18470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C0708_18475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0708_18475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0708_18480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0708_18515	COG1609	Transcriptional regulator
C0708_18520	COG3250	beta-galactosidase activity
C0708_18525	COG2731	YhcH YjgK YiaL family protein
C0708_18535	COG2801	Transposase and inactivated derivatives
C0708_18545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0708_18555	COG0385	Bile acid
C0708_18585	COG0583	DNA-binding transcription factor activity
C0708_18620	COG0210	DNA helicase
C0708_18630	COG0583	DNA-binding transcription factor activity
C0708_18670	COG1280	lysine exporter protein (LysE YggA)
C0708_18680	COG2962	Rard protein
C0708_18685	COG1012	belongs to the aldehyde dehydrogenase family
C0708_18690	COG1396	sequence-specific DNA binding
C0708_18705	COG0519	Catalyzes the synthesis of GMP from XMP
C0708_18705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0708_18735	COG1322	Protein conserved in bacteria
C0708_18750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0708_18750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0708_18755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0708_18760	COG0242	peptide deformylase activity
C0708_18770	COG0758	DNA mediated transformation
C0708_18775	COG2922	Belongs to the Smg family
C0708_18780	COG0551	DNA topoisomerase type I activity
C0708_18785	COG0009	L-threonylcarbamoyladenylate synthase
C0708_18790	COG0408	coproporphyrinogen oxidase activity
C0708_18795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0708_18805	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0708_18825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0708_18830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0708_18855	COG0174	glutamine synthetase
C0708_18865	COG1295	ribonuclease BN
C0708_18870	COG1490	D-aminoacyl-tRNA deacylase activity
C0708_18890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0708_18895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0708_18900	COG2610	gluconate transmembrane transporter activity
C0708_18905	COG3265	gluconokinase activity
C0708_18910	COG0129	dihydroxy-acid dehydratase activity
C0708_18915	COG0800	Aldolase
C0708_18930	COG1609	Transcriptional regulator
C0708_18940	COG4942	peptidase
C0708_18945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0708_18950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0708_18955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C0708_18970	COG0316	Belongs to the HesB IscA family
C0708_18970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C0708_18975	COG1040	competence protein
C0708_18980	COG0596	Alpha beta hydrolase
C0708_18995	COG2183	response to ionizing radiation
C0708_19005	COG0745	RESPONSE REGULATOR receiver
C0708_19010	COG2205	protein histidine kinase activity
C0708_19020	COG0051	transcription antitermination factor activity, RNA binding
C0708_19025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0708_19030	COG0088	Forms part of the polypeptide exit tunnel
C0708_19035	COG0089	rRNA binding
C0708_19040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0708_19045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0708_19050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0708_19055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0708_19060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0708_19065	COG0255	Belongs to the universal ribosomal protein uL29 family
C0708_19070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0708_19075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0708_19080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0708_19085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0708_19090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0708_19095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0708_19100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0708_19105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0708_19110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0708_19115	COG1841	ribosomal large subunit assembly
C0708_19120	COG0200	Binds to the 23S rRNA
C0708_19125	COG0201	protein transport
C0708_19130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0708_19135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0708_19140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0708_19145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0708_19150	COG0202	RNA polymerase activity
C0708_19155	COG0203	ribosomal protein L17
C0708_19215	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0708_19220	COG0583	DNA-binding transcription factor activity
C0708_19240	COG1770	oligopeptidase
C0708_19260	COG3714	YhhN family
C0708_19275	COG0583	DNA-binding transcription factor activity
C0708_19285	COG1301	dicarboxylic acid transport
C0708_19295	COG2095	MarC family integral membrane protein
C0708_19305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0708_19315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C0708_19320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0708_19345	COG0742	ribosomal rna small subunit methyltransferase
C0708_19350	COG0552	protein localization to endoplasmic reticulum
C0708_19355	COG2884	Cell division ATP-binding protein ftsE
C0708_19360	COG2177	Part of the ABC transporter FtsEX involved in
C0708_19370	COG0288	reversible hydration of carbon dioxide
C0708_19375	COG2188	Transcriptional regulator
C0708_19385	COG0010	Belongs to the arginase family
C0708_19390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0708_19395	COG2986	histidine ammonia-lyase
C0708_19460	COG1459	type II secretion system
C0708_19510	COG1077	Cell shape determining protein MreB Mrl
C0708_19515	COG1792	Involved in formation and maintenance of cell shape
C0708_19520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C0708_19525	COG0424	maF-like protein
C0708_19540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0708_19545	COG0312	modulator of DNA gyrase
C0708_19560	COG0477	Major facilitator Superfamily
C0708_19570	COG2321	neutral zinc metallopeptidase
C0708_19605	COG0189	ligase activity
C0708_19615	COG0745	RESPONSE REGULATOR receiver
C0708_19630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0708_19635	COG0352	thiamine-phosphate diphosphorylase activity
C0708_19640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0708_19650	COG2022	thiamine diphosphate biosynthetic process
C0708_19655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0708_19665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0708_19685	COG0110	maltose O-acetyltransferase activity
C0708_19700	COG3932	Exopolysaccharide synthesis, ExoD
C0708_19720	COG1733	regulation of RNA biosynthetic process
C0708_19725	COG0456	acetyltransferase
C0708_19755	COG1494	fructose-1,6-bisphosphatase
C0708_19770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0708_19775	COG5007	Belongs to the BolA IbaG family
C0708_19785	COG2854	intermembrane phospholipid transfer
C0708_19790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0708_19795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0708_19800	COG1127	ABC transporter
C0708_19810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0708_19820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C0708_19825	COG1137	ATPase activity
C0708_19830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C0708_19840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_19845	COG1660	Displays ATPase and GTPase activities
C0708_19850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0708_19870	COG3964	amidohydrolase
C0708_19900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0708_19905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0708_19915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0708_19920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0708_19925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0708_19930	COG0723	plastoquinol--plastocyanin reductase activity
C0708_19935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0708_19945	COG0625	glutathione transferase activity
C0708_19950	COG2969	positive regulation of protein catabolic process
C0708_19955	COG2823	Periplasmic or secreted lipoprotein
C0708_19960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0708_19965	COG0792	nuclease activity
C0708_19970	COG3107	peptidoglycan biosynthetic process
C0708_19975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0708_19985	COG2001	Belongs to the MraZ family
C0708_19990	COG0275	rRNA processing
C0708_19995	COG3116	cell division
C0708_20000	COG0768	penicillin binding
C0708_20010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0708_20015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0708_20025	COG0772	Belongs to the SEDS family
C0708_20030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0708_20035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0708_20045	COG0849	cell division
C0708_20050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0708_20055	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C0708_20065	COG0653	protein targeting
C0708_20075	COG0494	nUDIX hydrolase
C0708_20080	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C0708_20085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C0708_20100	COG1459	type II secretion system
C0708_20105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0708_20135	COG2186	Transcriptional regulator
C0708_20140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0708_20145	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0708_20150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0708_20160	COG0840	transmembrane signaling receptor activity
C0708_20165	COG0840	transmembrane signaling receptor activity
C0708_20190	COG1280	lysine exporter protein (LysE YggA)
C0708_20200	COG0523	cobalamin synthesis protein
C0708_20220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0708_20270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0708_20280	COG1546	Belongs to the CinA family
C0708_20285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0708_20290	COG2137	regulation of response to DNA damage stimulus
C0708_20295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0708_20300	COG0527	aspartate kinase activity
C0708_20305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C0708_20340	COG1686	Belongs to the peptidase S11 family
C0708_20345	COG0586	Pfam SNARE associated Golgi protein
C0708_20355	COG0525	valine-tRNA ligase activity
C0708_20360	COG2927	DNA polymerase III (CHI subunit)
C0708_20365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0708_20370	COG0795	lipopolysaccharide-transporting ATPase activity
C0708_20375	COG0795	lipopolysaccharide-transporting ATPase activity
C0708_20390	COG0582	viral genome integration into host DNA
C0708_20455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0708_20465	COG4968	Prepilin-type N-terminal cleavage methylation domain
C0708_20470	COG0084	hydrolase, TatD family'
C0708_20475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0708_20485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0708_20490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C0708_20495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C0708_20500	COG0813	purine-nucleoside phosphorylase activity
C0708_20505	COG5002	protein histidine kinase activity
C0708_20505	COG3447	MASE1 domain protein
C0708_20505	COG5001	Diguanylate cyclase
C0708_20515	COG0560	Phosphoserine phosphatase
C0708_20530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0708_20540	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C0708_20545	COG0776	regulation of translation
C0708_20560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0708_20565	COG0735	belongs to the Fur family
C0708_20590	COG0513	Belongs to the DEAD box helicase family
C0708_20595	COG3022	response to hydroperoxide
C0708_20610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0708_20615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0708_20620	COG0762	integral membrane protein
C0708_20625	COG1872	DUF167
C0708_20645	COG3112	Uncharacterised protein family (UPF0231)
C0708_20650	COG3835	regulator
C0708_20655	COG2610	gluconate transmembrane transporter activity
C0708_20660	COG1929	Belongs to the glycerate kinase type-1 family
C0708_20675	COG0583	DNA-binding transcription factor activity
C0708_20680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0708_20705	COG1840	ABC-type Fe3 transport system, periplasmic component
C0708_20715	COG3842	ATPase activity
C0708_20720	COG2837	iron assimilation
C0708_20725	COG1438	arginine binding
C0708_20730	COG1126	abc transporter atp-binding protein
C0708_20735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0708_20740	COG4215	(ABC) transporter
C0708_20745	COG4160	amino acid transport
C0708_20750	COG0039	L-malate dehydrogenase activity
C0708_20760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C0708_20765	COG1017	nitric oxide dioxygenase activity
C0708_20765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0708_20775	COG4536	flavin adenine dinucleotide binding
C0708_20780	COG4137	Cytochrome C assembly protein
C0708_20795	COG0228	four-way junction DNA binding
C0708_20800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0708_20805	COG0336	Belongs to the RNA methyltransferase TrmD family
C0708_20810	COG0335	large ribosomal subunit rRNA binding
C0708_20835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0708_20840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0708_20845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0708_20855	COG0583	DNA-binding transcription factor activity
C0708_20860	COG0640	Transcriptional regulator
C0708_20865	COG0268	Binds directly to 16S ribosomal RNA
C0708_20870	COG0728	peptidoglycan biosynthetic process
C0708_20875	COG0196	riboflavin kinase activity
C0708_20880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0708_20885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0708_20890	COG1047	Peptidyl-prolyl cis-trans
C0708_20895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0708_20900	COG4968	Prepilin-type N-terminal cleavage methylation domain
C0708_20935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0708_20935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0708_20950	COG1854	S-ribosylhomocysteine lyase activity
C0708_20955	COG3706	GGDEF domain
C0708_20965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0708_20975	COG2153	protein acetylation
C0708_20985	COG1914	H( )-stimulated, divalent metal cation uptake system
C0708_20990	COG0360	Binds together with S18 to 16S ribosomal RNA
C0708_20995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0708_21000	COG0359	binds to the 23S rRNA
C0708_21040	COG1238	metal cluster binding
C0708_21045	COG0612	Peptidase, M16
C0708_21050	COG2918	glutathione biosynthetic process
C0708_21055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C0708_21060	COG1027	Aspartate ammonia-lyase
C0708_21065	COG3030	protein affecting phage T7 exclusion by the F plasmid
C0708_21075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0708_21080	COG0459	protein refolding
C0708_21100	COG0564	pseudouridine synthase activity
C0708_21105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0708_21135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0708_21145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C0708_21150	COG4208	sulfate ABC transporter
C0708_21155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C0708_21160	COG0583	DNA-binding transcription factor activity
C0708_21165	COG3397	chitin binding
C0708_21205	COG1328	CTP reductase activity
C0708_21210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0708_21250	COG1215	transferase activity, transferring glycosyl groups
C0708_21260	COG3118	belongs to the thioredoxin family
C0708_21260	COG0457	Tetratricopeptide repeat
C0708_21300	COG0840	transmembrane signaling receptor activity
C0708_21310	COG4166	transmembrane transport
C0708_21325	COG1024	Enoyl-CoA hydratase
C0708_21340	COG4221	oxidoreductase activity
C0708_21345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0708_21350	COG0442	prolyl-tRNA aminoacylation
C0708_21355	COG0840	transmembrane signaling receptor activity
C0708_21360	COG0632	four-way junction helicase activity
C0708_21365	COG2255	four-way junction helicase activity
C0708_21375	COG1271	oxidase subunit
C0708_21380	COG1294	oxidase, subunit
C0708_21385	COG4890	Cyd operon protein YbgT
C0708_21390	COG3790	cyd operon protein YbgE
C0708_21395	COG0824	Thioesterase
C0708_21400	COG0811	peptide transport
C0708_21420	COG2885	chlorophyll binding
C0708_21425	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C0708_21500	COG0840	transmembrane signaling receptor activity
C0708_21505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0708_21510	COG0676	glucose-6-phosphate 1-epimerase activity
C0708_21515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0708_21520	COG1640	4-alpha-glucanotransferase
C0708_21525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0708_21555	COG2130	NADP-dependent
C0708_21560	COG1846	Transcriptional regulator
C0708_21575	COG1522	sequence-specific DNA binding
C0708_21590	COG0561	phosphatase activity
C0708_21605	COG0733	neurotransmitter:sodium symporter activity
C0708_21625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0708_21640	COG1794	racemase activity, acting on amino acids and derivatives
C0708_21650	COG1022	Amp-dependent synthetase and ligase
C0708_21660	COG0456	acetyltransferase
C0708_21675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C0708_21680	COG5002	protein histidine kinase activity
C0708_21680	COG5001	Diguanylate cyclase
C0708_21685	COG3706	GGDEF domain
C0708_21685	COG0745	RESPONSE REGULATOR receiver
C0708_21710	COG1902	pentaerythritol trinitrate reductase activity
C0708_21725	COG2957	Belongs to the agmatine deiminase family
C0708_21755	COG1917	Cupin 2, conserved barrel domain protein
C0708_21755	COG2207	Transcriptional regulator
C0708_21765	COG0513	Belongs to the DEAD box helicase family
C0708_21770	COG2203	Gaf domain
C0708_21770	COG2199	diguanylate cyclase activity
C0708_21805	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C0708_21815	COG1136	(ABC) transporter
C0708_21815	COG0577	efflux transmembrane transporter activity
C0708_21820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_21880	COG1280	lysine exporter protein (LysE YggA)
C0708_21885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C0708_21900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0708_21930	COG0745	RESPONSE REGULATOR receiver
C0708_21935	COG3104	oligopeptide transport
C0708_21940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0708_21945	COG1555	photosystem II stabilization
C0708_21955	COG2350	Protein conserved in bacteria
C0708_21960	COG2917	probably involved in intracellular septation
C0708_21965	COG0076	glutamate decarboxylase activity
C0708_21975	COG2985	domain, Protein
C0708_21975	COG0569	domain protein