locus-tag	class	description
C1C92_00075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1C92_00085	COG1684	flagellar biosynthetic protein fliR
C1C92_00140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1C92_00150	COG1677	Flagellar hook-basal body complex protein FliE
C1C92_00165	COG1393	Belongs to the ArsC family
C1C92_00170	COG0798	PFAM Bile acid sodium symporter
C1C92_00175	COG0640	Transcriptional regulator
C1C92_00185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1C92_00200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_00205	COG0444	Belongs to the ABC transporter superfamily
C1C92_00210	COG4608	Belongs to the ABC transporter superfamily
C1C92_00220	COG2971	BadF BadG BcrA BcrD
C1C92_00230	COG0840	transmembrane signaling receptor activity
C1C92_00245	COG3724	N-succinylarginine dihydrolase activity
C1C92_00250	COG0616	signal peptide processing
C1C92_00255	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_00260	COG0583	DNA-binding transcription factor activity
C1C92_00270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1C92_00280	COG0583	DNA-binding transcription factor activity
C1C92_00290	COG1881	PFAM PEBP family protein
C1C92_00300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1C92_00300	COG3408	Glycogen debranching enzyme
C1C92_00305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C92_00310	COG0739	heme binding
C1C92_00315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1C92_00355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1C92_00365	COG3091	SprT-like family
C1C92_00375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1C92_00380	COG0189	ligase activity
C1C92_00390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1C92_00410	COG1115	amino acid carrier protein
C1C92_00415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1C92_00430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1C92_00440	COG1301	dicarboxylic acid transport
C1C92_00445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1C92_00450	COG2912	Transglutaminase-like superfamily
C1C92_00460	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C92_00465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1C92_00470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1C92_00475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1C92_00480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1C92_00490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1C92_00495	COG0193	aminoacyl-tRNA hydrolase activity
C1C92_00500	COG0012	GTP binding
C1C92_00545	COG0471	metal ion transport
C1C92_00545	COG0490	domain, Protein
C1C92_00570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_00595	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_00605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1C92_00620	COG0180	Tryptophanyl-tRNA synthetase
C1C92_00625	COG0546	phosphoglycolate phosphatase activity
C1C92_00630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1C92_00635	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1C92_00645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1C92_00650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1C92_00680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1C92_00685	COG0583	DNA-binding transcription factor activity
C1C92_00700	COG0583	DNA-binding transcription factor activity
C1C92_00710	COG0739	heme binding
C1C92_00720	COG3264	Mechanosensitive ion channel
C1C92_00720	COG1511	domain protein
C1C92_00725	COG0584	glycerophosphoryl diester phosphodiesterase
C1C92_00735	COG1053	succinate dehydrogenase
C1C92_00740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1C92_00745	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C92_00750	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C92_00765	COG3214	Protein conserved in bacteria
C1C92_00770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_00790	COG0300	oxidoreductase activity
C1C92_00810	COG4067	protein conserved in archaea
C1C92_00810	COG0189	ligase activity
C1C92_00815	COG0516	GMP reductase activity
C1C92_00825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1C92_00830	COG2011	ABC-type metal ion transport system permease component
C1C92_00840	COG1464	Belongs to the NlpA lipoprotein family
C1C92_00855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C92_00865	COG2199	diguanylate cyclase activity
C1C92_00875	COG2199	diguanylate cyclase activity
C1C92_00880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_00895	COG1335	isochorismatase
C1C92_00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_00910	COG1702	phosphate starvation-inducible protein PhoH
C1C92_00915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1C92_00920	COG4535	Mg2 and Co2 transporter CorC
C1C92_00925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1C92_00930	COG2888	peptidyl-tyrosine sulfation
C1C92_00935	COG0495	leucyl-tRNA aminoacylation
C1C92_00950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1C92_00955	COG0799	negative regulation of ribosome biogenesis
C1C92_00960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1C92_00965	COG0768	penicillin binding
C1C92_00970	COG0772	Belongs to the SEDS family
C1C92_00975	COG2951	lytic endotransglycosylase activity
C1C92_00980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1C92_00985	COG1686	Belongs to the peptidase S11 family
C1C92_00990	COG2921	Belongs to the UPF0250 family
C1C92_00995	COG0321	lipoyl(octanoyl) transferase activity
C1C92_01000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1C92_01010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_01025	COG0789	Transcriptional regulator
C1C92_01030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1C92_01040	COG1970	mechanosensitive ion channel activity
C1C92_01045	COG4974	Belongs to the 'phage' integrase family
C1C92_01055	COG0312	modulator of DNA gyrase
C1C92_01060	COG0312	modulator of DNA gyrase
C1C92_01080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_01095	COG1422	Protein of unknown function (DUF1090)
C1C92_01100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C92_01105	COG2211	Major facilitator Superfamily
C1C92_01110	COG1185	polyribonucleotide nucleotidyltransferase activity
C1C92_01115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1C92_01120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1C92_01125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1C92_01130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1C92_01135	COG0195	Participates in both transcription termination and antitermination
C1C92_01140	COG0779	Required for maturation of 30S ribosomal subunits
C1C92_01155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1C92_01160	COG0149	triose-phosphate isomerase activity
C1C92_01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1C92_01170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1C92_01180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1C92_01185	COG1534	Rna-binding protein
C1C92_01200	COG1360	Flagellar Motor Protein
C1C92_01205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_01210	COG1722	exodeoxyribonuclease VII activity
C1C92_01215	COG0142	geranyltranstransferase activity
C1C92_01220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1C92_01240	COG4172	Belongs to the ABC transporter superfamily
C1C92_01245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1C92_01250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1C92_01255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_01260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1C92_01275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C92_01275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C92_01280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1C92_01310	COG3550	peptidyl-serine autophosphorylation
C1C92_01340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1C92_01355	COG3381	protein complex oligomerization
C1C92_01370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C92_01375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1C92_01380	COG0511	ligase activity, forming carbon-carbon bonds
C1C92_01385	COG0439	Biotin carboxylase
C1C92_01390	COG3924	membrane
C1C92_01395	COG4145	pantothenate transmembrane transporter activity
C1C92_01400	COG1263	PTS System
C1C92_01400	COG2190	(PTS) system
C1C92_01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_01405	COG0583	DNA-binding transcription factor activity
C1C92_01410	COG0604	alcohol dehydrogenase
C1C92_01415	COG2264	protein methyltransferase activity
C1C92_01420	COG0110	maltose O-acetyltransferase activity
C1C92_01430	COG0778	Nitroreductase
C1C92_01440	COG0616	signal peptide processing
C1C92_01460	COG3139	Protein of unknown function (DUF1315)
C1C92_01465	COG0252	asparaginase activity
C1C92_01470	COG0786	glutamate:sodium symporter activity
C1C92_01485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1C92_01490	COG0384	phenazine biosynthesis protein PhzF
C1C92_01495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1C92_01500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_01505	COG0175	sulfate reduction
C1C92_01510	COG2113	Glycine betaine
C1C92_01515	COG4176	ABC-type proline glycine betaine transport system permease component
C1C92_01520	COG4175	Glycine betaine
C1C92_01530	COG3610	response to peptide
C1C92_01535	COG2966	Psort location CytoplasmicMembrane, score
C1C92_01545	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C92_01570	COG2313	pseudouridylate synthase activity
C1C92_01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_01580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_01580	COG2146	nitrite reductase [NAD(P)H] activity
C1C92_01585	COG2146	nitrite reductase [NAD(P)H] activity
C1C92_01585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_01590	COG1116	anion transmembrane transporter activity
C1C92_01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1C92_01600	COG1116	anion transmembrane transporter activity
C1C92_01600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1C92_01610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_01610	COG1648	precorrin-2 dehydrogenase activity
C1C92_01615	COG0243	molybdopterin cofactor binding
C1C92_01640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1C92_01660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1C92_01670	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C92_01680	COG4608	Belongs to the ABC transporter superfamily
C1C92_01685	COG0444	Belongs to the ABC transporter superfamily
C1C92_01695	COG4239	(ABC) transporter, permease
C1C92_01700	COG4174	ABC transporter (Permease)
C1C92_01705	COG4206	TonB-dependent receptor
C1C92_01715	COG0811	peptide transport
C1C92_01720	COG0811	peptide transport
C1C92_01725	COG0848	biopolymer transport protein
C1C92_01780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_01785	COG0840	transmembrane signaling receptor activity
C1C92_01795	COG1278	Cold shock
C1C92_01835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1C92_01840	COG1162	GTPase activity
C1C92_01845	COG0688	phosphatidylethanolamine metabolic process
C1C92_01850	COG4628	conserved protein (DUF2132)
C1C92_01870	COG3300	MHYT domain
C1C92_01870	COG5001	Diguanylate cyclase
C1C92_01875	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1C92_01900	COG1132	(ABC) transporter
C1C92_01910	COG2897	thiosulfate sulfurtransferase activity
C1C92_01915	COG2066	Belongs to the glutaminase family
C1C92_01920	COG3171	Protein conserved in bacteria
C1C92_01925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1C92_01930	COG4935	Belongs to the peptidase S8 family
C1C92_01930	COG2234	aminopeptidase activity
C1C92_01935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_01940	COG2200	EAL domain
C1C92_01945	COG1090	epimerase
C1C92_01950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1C92_01955	COG4181	ATPase activity
C1C92_01960	COG2755	lipolytic protein G-D-S-L family
C1C92_01965	COG0784	Response regulator, receiver
C1C92_01965	COG0835	chemotaxis
C1C92_01975	COG0516	GMP reductase activity
C1C92_01975	COG0517	IMP dehydrogenase activity
C1C92_01980	COG0488	(ABC) transporter
C1C92_01990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1C92_02030	COG0789	Transcriptional regulator
C1C92_02040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C92_02050	COG0668	transmembrane transport
C1C92_02060	COG2731	YhcH YjgK YiaL family protein
C1C92_02070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_02075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_02080	COG3227	Zinc metalloprotease (Elastase)
C1C92_02085	COG0583	DNA-binding transcription factor activity
C1C92_02090	COG0477	Major facilitator Superfamily
C1C92_02110	COG2985	domain, Protein
C1C92_02110	COG0569	domain protein
C1C92_02115	COG1272	protein, Hemolysin III
C1C92_02120	COG0076	glutamate decarboxylase activity
C1C92_02125	COG2917	probably involved in intracellular septation
C1C92_02130	COG2350	Protein conserved in bacteria
C1C92_02140	COG1555	photosystem II stabilization
C1C92_02145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1C92_02150	COG3104	oligopeptide transport
C1C92_02155	COG0745	RESPONSE REGULATOR receiver
C1C92_02185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_02200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1C92_02205	COG1280	lysine exporter protein (LysE YggA)
C1C92_02230	COG0316	Belongs to the HesB IscA family
C1C92_02240	COG0038	chloride channel
C1C92_02245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1C92_02260	COG0671	phosphoesterase, PA-phosphatase related
C1C92_02270	COG0583	DNA-binding transcription factor activity
C1C92_02275	COG2076	Multidrug Resistance protein
C1C92_02285	COG0346	lactoylglutathione lyase activity
C1C92_02290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C92_02295	COG1643	Atp-dependent helicase
C1C92_02305	COG1489	DNA binding
C1C92_02310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1C92_02315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_02325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1C92_02330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1C92_02335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1C92_02345	COG0842	Transport permease protein
C1C92_02350	COG1131	(ABC) transporter
C1C92_02365	COG0163	prenyltransferase activity
C1C92_02370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C92_02375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1C92_02390	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1C92_02405	COG1136	(ABC) transporter
C1C92_02445	COG2801	Transposase and inactivated derivatives
C1C92_02450	COG0529	Catalyzes the synthesis of activated sulfate
C1C92_02455	COG0471	metal ion transport
C1C92_02455	COG3273	potassium ion transport
C1C92_02460	COG2895	sulfate adenylyltransferase (ATP) activity
C1C92_02465	COG0175	sulfate reduction
C1C92_02470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_02470	COG1648	precorrin-2 dehydrogenase activity
C1C92_02475	COG0330	HflC and HflK could
C1C92_02480	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1C92_02490	COG0673	inositol 2-dehydrogenase activity
C1C92_02500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1C92_02505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C92_02510	COG3036	rescue of stalled ribosome
C1C92_02525	COG0138	bifunctional purine biosynthesis protein purh
C1C92_02560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1C92_02565	COG0358	DNA primase activity
C1C92_02570	COG1610	YqeY-like protein
C1C92_02575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1C92_02580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1C92_02590	COG1388	LysM domain
C1C92_02590	COG4942	peptidase
C1C92_02595	COG1238	metal cluster binding
C1C92_02600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1C92_02605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1C92_02610	COG0585	pseudouridine synthase activity
C1C92_02620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1C92_02625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1C92_02630	COG0148	phosphopyruvate hydratase activity
C1C92_02635	COG0504	CTP synthase activity
C1C92_02640	COG3956	TIGRFAM MazG family protein
C1C92_02645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C92_02650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_02660	COG4807	Protein conserved in bacteria
C1C92_02665	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1C92_02670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1C92_02675	COG1381	Involved in DNA repair and RecF pathway recombination
C1C92_02685	COG0571	ribonuclease III activity
C1C92_02690	COG0681	Belongs to the peptidase S26 family
C1C92_02695	COG0481	GTPase activity
C1C92_02710	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1C92_02715	COG1595	DNA-templated transcription, initiation
C1C92_02720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1C92_02730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1C92_02740	COG0583	DNA-binding transcription factor activity
C1C92_02775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_02785	COG0126	phosphoglycerate kinase activity
C1C92_02790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C92_02795	COG1940	carbohydrate kinase activity
C1C92_02800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1C92_02805	COG2816	NAD+ diphosphatase activity
C1C92_02810	COG4991	sh3 domain protein
C1C92_02815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C92_02830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1C92_02835	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_02850	COG1505	serine-type exopeptidase activity
C1C92_02855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C92_02860	COG0765	amino acid transport
C1C92_02865	COG0765	amino acid transport
C1C92_02870	COG1126	abc transporter atp-binding protein
C1C92_02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_02880	COG3174	membrane
C1C92_02885	COG0110	maltose O-acetyltransferase activity
C1C92_02925	COG0583	DNA-binding transcription factor activity
C1C92_02930	COG0165	Argininosuccinate lyase
C1C92_02935	COG0137	argininosuccinate synthase activity
C1C92_02945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C92_02950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1C92_02960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1C92_02965	COG3447	MASE1 domain protein
C1C92_02965	COG5001	Diguanylate cyclase
C1C92_02965	COG5002	protein histidine kinase activity
C1C92_02970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1C92_03005	COG0583	DNA-binding transcription factor activity
C1C92_03010	COG1380	Effector of murein hydrolase LrgA
C1C92_03015	COG1346	cytolysis
C1C92_03020	COG0527	aspartate kinase activity
C1C92_03020	COG0460	homoserine dehydrogenase
C1C92_03025	COG0626	cystathionine gamma-synthase activity
C1C92_03040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_03050	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1C92_03055	COG0494	nUDIX hydrolase
C1C92_03060	COG1011	Hydrolase
C1C92_03075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C92_03090	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1C92_03100	COG3156	type II secretion system protein K
C1C92_03105	COG4795	General secretion pathway protein
C1C92_03110	COG2165	general secretion pathway protein
C1C92_03120	COG2165	general secretion pathway protein
C1C92_03125	COG1459	type II secretion system
C1C92_03130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C92_03140	COG3031	protein transport across the cell outer membrane
C1C92_03150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1C92_03155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1C92_03170	COG0456	acetyltransferase
C1C92_03175	COG3133	Outer membrane lipoprotein
C1C92_03180	COG3025	triphosphatase activity
C1C92_03185	COG1392	Phosphate transport regulator
C1C92_03190	COG0306	phosphate transporter
C1C92_03195	COG0617	tRNA 3'-terminal CCA addition
C1C92_03200	COG3267	Type II secretory pathway component ExeA
C1C92_03200	COG3409	Peptidoglycan-binding domain 1 protein
C1C92_03210	COG1194	a g-specific adenine glycosylase
C1C92_03215	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1C92_03230	COG3240	lipase activity
C1C92_03240	COG3009	Protein conserved in bacteria
C1C92_03245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C92_03245	COG3008	intermembrane lipid transfer
C1C92_03250	COG2995	paraquat-inducible protein a
C1C92_03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_03265	COG2203	Gaf domain
C1C92_03265	COG5001	Diguanylate cyclase
C1C92_03265	COG4251	negative regulation of phosphorylation
C1C92_03265	COG3706	GGDEF domain
C1C92_03270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C92_03275	COG2813	Specifically methylates the guanine in position
C1C92_03280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1C92_03285	COG0297	glycogen (starch) synthase activity
C1C92_03325	COG1757	Na H antiporter
C1C92_03330	COG0583	DNA-binding transcription factor activity
C1C92_03335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1C92_03340	COG3842	ATPase activity
C1C92_03345	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C92_03350	COG1177	transmembrane transport
C1C92_03355	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_03360	COG0109	protoheme IX farnesyltransferase activity
C1C92_03390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1C92_03400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C92_03400	COG1565	acr, cog1565
C1C92_03405	COG1444	tRNA N-acetyltransferase activity
C1C92_03425	COG1803	Methylglyoxal synthase
C1C92_03440	COG0252	asparaginase activity
C1C92_03460	COG1263	PTS System
C1C92_03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_03465	COG0366	Alpha amylase catalytic
C1C92_03470	COG0110	maltose O-acetyltransferase activity
C1C92_03475	COG1522	sequence-specific DNA binding
C1C92_03505	COG3068	Protein conserved in bacteria
C1C92_03515	COG0739	heme binding
C1C92_03535	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1C92_03540	COG1121	(ABC) transporter
C1C92_03545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1C92_03550	COG0583	DNA-binding transcription factor activity
C1C92_03560	COG1573	uracil-dna glycosylase
C1C92_03565	COG2962	Rard protein
C1C92_03570	COG2827	Endonuclease containing a URI domain
C1C92_03585	COG1842	Phage shock protein A
C1C92_03590	COG0204	Acyl-transferase
C1C92_03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_03620	COG0484	heat shock protein binding
C1C92_03655	COG2801	Transposase and inactivated derivatives
C1C92_03670	COG1289	transmembrane transporter activity
C1C92_03675	COG1566	PFAM secretion protein HlyD family protein
C1C92_03690	COG1051	belongs to the nudix hydrolase family
C1C92_03695	COG3150	esterase
C1C92_03705	COG3151	Protein conserved in bacteria
C1C92_03710	COG0494	nUDIX hydrolase
C1C92_03715	COG1538	Outer membrane efflux protein
C1C92_03720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1C92_03720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1C92_03725	COG1560	Kdo2-lipid A biosynthetic process
C1C92_03740	COG2771	luxR family
C1C92_03755	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1C92_03765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_03765	COG2213	PTS system mannitol-specific
C1C92_03770	COG0246	Mannitol dehydrogenase
C1C92_03775	COG3722	fumarate hydratase activity
C1C92_03780	COG3263	regulation of cellular component size
C1C92_03800	COG1671	Belongs to the UPF0178 family
C1C92_03815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_03820	COG0513	Belongs to the DEAD box helicase family
C1C92_03840	COG1575	Belongs to the MenA family. Type 1 subfamily
C1C92_03845	COG1169	isochorismate synthase
C1C92_03850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1C92_03855	COG0596	Alpha beta hydrolase
C1C92_03860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1C92_03870	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_03875	COG3291	Pkd domain containing protein
C1C92_03880	COG2949	membrane
C1C92_03885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1C92_03895	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1C92_03925	COG2873	o-acetylhomoserine
C1C92_03935	COG1979	alcohol dehydrogenase
C1C92_03950	COG4221	oxidoreductase activity
C1C92_03970	COG1285	pathogenesis
C1C92_03985	COG1368	sulfuric ester hydrolase activity
C1C92_03990	COG1522	sequence-specific DNA binding
C1C92_04000	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1C92_04010	COG1546	Belongs to the CinA family
C1C92_04010	COG1058	Belongs to the CinA family
C1C92_04015	COG1988	membrane-bound metal-dependent
C1C92_04030	COG0561	phosphatase activity
C1C92_04035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1C92_04045	COG1011	Hydrolase
C1C92_04060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1C92_04065	COG0019	diaminopimelate decarboxylase activity
C1C92_04075	COG1965	Belongs to the frataxin family
C1C92_04080	COG0400	carboxylic ester hydrolase activity
C1C92_04085	COG3072	Adenylate cyclase
C1C92_04090	COG0181	hydroxymethylbilane synthase activity
C1C92_04095	COG1587	Uroporphyrinogen-III synthase
C1C92_04100	COG2959	enzyme of heme biosynthesis
C1C92_04105	COG3071	HemY protein
C1C92_04110	COG0312	modulator of DNA gyrase
C1C92_04115	COG3028	Belongs to the UPF0307 family
C1C92_04125	COG2926	Belongs to the UPF0265 family
C1C92_04155	COG1396	sequence-specific DNA binding
C1C92_04160	COG3135	benzoate transporter
C1C92_04185	COG0840	transmembrane signaling receptor activity
C1C92_04190	COG3047	cAMP biosynthetic process
C1C92_04195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1C92_04200	COG2197	response regulator
C1C92_04245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_04280	COG1396	sequence-specific DNA binding
C1C92_04305	COG1278	Cold shock
C1C92_04310	COG2205	protein histidine kinase activity
C1C92_04315	COG0745	RESPONSE REGULATOR receiver
C1C92_04335	COG3706	GGDEF domain
C1C92_04340	COG0347	Belongs to the P(II) protein family
C1C92_04345	COG0004	ammonium transporteR
C1C92_04360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_04365	COG1074	ATP-dependent DNA helicase activity
C1C92_04370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1C92_04375	COG2259	Doxx family
C1C92_04380	COG1741	Belongs to the pirin family
C1C92_04390	COG0583	DNA-binding transcription factor activity
C1C92_04415	COG1175	transmembrane transport
C1C92_04425	COG3842	ATPase activity
C1C92_04455	COG0456	acetyltransferase
C1C92_04460	COG0753	catalase activity
C1C92_04480	COG0494	nUDIX hydrolase
C1C92_04485	COG0628	permease
C1C92_04495	COG2957	Belongs to the agmatine deiminase family
C1C92_04510	COG2957	Belongs to the agmatine deiminase family
C1C92_04515	COG0583	DNA-binding transcription factor activity
C1C92_04530	COG1461	Dihydroxyacetone kinase
C1C92_04535	COG2376	Dihydroxyacetone kinase
C1C92_04540	COG2252	PERMEase
C1C92_04545	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C1C92_04575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C92_04580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C92_04585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1C92_04590	COG0049	tRNA binding
C1C92_04595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1C92_04600	COG2168	tRNA wobble position uridine thiolation
C1C92_04610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C92_04615	COG0251	oxidation-reduction process
C1C92_04620	COG2964	Protein conserved in bacteria
C1C92_04625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1C92_04630	COG0085	RNA polymerase activity
C1C92_04635	COG0222	ribosome binding
C1C92_04640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1C92_04645	COG0081	regulation of translation
C1C92_04650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1C92_04655	COG0250	Participates in transcription elongation, termination and antitermination
C1C92_04670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C92_04695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1C92_04700	COG0569	domain protein
C1C92_04705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_04710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1C92_04715	COG3005	denitrification pathway
C1C92_04735	COG0745	RESPONSE REGULATOR receiver
C1C92_04770	COG2204	response regulator
C1C92_04780	COG2205	protein histidine kinase activity
C1C92_04800	COG0517	IMP dehydrogenase activity
C1C92_04800	COG0516	GMP reductase activity
C1C92_04810	COG1522	sequence-specific DNA binding
C1C92_04815	COG2502	aspartate--ammonia ligase
C1C92_04830	COG0583	DNA-binding transcription factor activity
C1C92_04840	COG0542	response to heat
C1C92_04850	COG0564	pseudouridine synthase activity
C1C92_04855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_04860	COG3681	Belongs to the UPF0597 family
C1C92_04865	COG2964	Protein conserved in bacteria
C1C92_04870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1C92_04875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1C92_04880	COG1979	alcohol dehydrogenase
C1C92_04885	COG2207	Transcriptional regulator
C1C92_04910	COG0583	DNA-binding transcription factor activity
C1C92_04930	COG0540	Belongs to the ATCase OTCase family
C1C92_04935	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C1C92_04940	COG1438	arginine binding
C1C92_04950	COG1288	antiporter activity
C1C92_04955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1C92_04995	COG3250	beta-galactosidase activity
C1C92_05000	COG1609	Transcriptional regulator
C1C92_05005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_05015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1C92_05020	COG2017	converts alpha-aldose to the beta-anomer
C1C92_05025	COG0667	Aldo Keto reductase
C1C92_05030	COG1968	undecaprenyl-diphosphatase activity
C1C92_05035	COG3806	Anti-sigma factor
C1C92_05040	COG1595	DNA-templated transcription, initiation
C1C92_05060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1C92_05065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1C92_05070	COG0477	Major facilitator Superfamily
C1C92_05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_05090	COG1131	(ABC) transporter
C1C92_05095	COG0842	Transport permease protein
C1C92_05100	COG0842	Transport permease protein
C1C92_05105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_05115	COG2116	formate transmembrane transporter activity
C1C92_05120	COG1648	precorrin-2 dehydrogenase activity
C1C92_05120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_05125	COG2239	Acts as a magnesium transporter
C1C92_05130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C92_05135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1C92_05145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1C92_05155	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_05160	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_05165	COG2050	protein possibly involved in aromatic compounds catabolism
C1C92_05180	COG2258	MOSC domain
C1C92_05185	COG1177	transmembrane transport
C1C92_05190	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C92_05195	COG3842	ATPase activity
C1C92_05215	COG0174	glutamine synthetase
C1C92_05235	COG3045	CreA protein
C1C92_05240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C92_05245	COG0443	Heat shock 70 kDa protein
C1C92_05260	COG0366	Alpha amylase catalytic
C1C92_05270	COG4310	Domain of unknown function (DUF2172)
C1C92_05305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_05310	COG0745	RESPONSE REGULATOR receiver
C1C92_05315	COG2205	protein histidine kinase activity
C1C92_05325	COG0281	malic enzyme
C1C92_05330	COG0702	epimerase
C1C92_05335	COG0254	rRNA binding
C1C92_05340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1C92_05345	COG1309	transcriptional regulator
C1C92_05365	COG0129	dihydroxy-acid dehydratase activity
C1C92_05375	COG3978	acetolactate synthase activity
C1C92_05390	COG0606	chelatase, subunit chli
C1C92_05395	COG0204	Acyl-transferase
C1C92_05400	COG0204	Acyl-transferase
C1C92_05405	COG1683	Conserved Protein
C1C92_05415	COG1335	isochorismatase
C1C92_05425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1C92_05430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1C92_05440	COG3084	Protein conserved in bacteria
C1C92_05445	COG3706	GGDEF domain
C1C92_05445	COG5001	Diguanylate cyclase
C1C92_05445	COG4251	negative regulation of phosphorylation
C1C92_05445	COG2203	Gaf domain
C1C92_05460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1C92_05465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1C92_05470	COG1561	YicC-like family, N-terminal region
C1C92_05480	COG1519	Transferase
C1C92_05485	COG0859	PFAM glycosyl transferase family 9
C1C92_05490	COG0463	Glycosyl transferase, family 2
C1C92_05495	COG0859	PFAM glycosyl transferase family 9
C1C92_05500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1C92_05505	COG2990	Protein conserved in bacteria
C1C92_05510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1C92_05520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1C92_05525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1C92_05530	COG2003	Belongs to the UPF0758 family
C1C92_05535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1C92_05540	COG0756	dUTP diphosphatase activity
C1C92_05545	COG1309	transcriptional regulator
C1C92_05565	COG0668	transmembrane transport
C1C92_05575	COG0166	Belongs to the GPI family
C1C92_05580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1C92_05585	COG0583	DNA-binding transcription factor activity
C1C92_05595	COG1042	CoA-binding domain protein
C1C92_05595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_05595	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C92_05625	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1C92_05630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_05635	COG1739	Uncharacterized protein family UPF0029
C1C92_05640	COG0006	proline dipeptidase activity
C1C92_05645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C92_05650	COG1024	Enoyl-CoA hydratase
C1C92_05650	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1C92_05655	COG0183	Belongs to the thiolase family
C1C92_05660	COG0745	RESPONSE REGULATOR receiver
C1C92_05685	COG0425	Belongs to the sulfur carrier protein TusA family
C1C92_05690	COG0251	oxidation-reduction process
C1C92_05695	COG2885	chlorophyll binding
C1C92_05705	COG1335	isochorismatase
C1C92_05710	COG2818	Glycosylase
C1C92_05715	COG0752	glycyl-tRNA synthetase alpha subunit
C1C92_05720	COG0751	glycine-tRNA ligase activity
C1C92_05730	COG3604	Transcriptional regulator
C1C92_05735	COG0426	domain, Protein
C1C92_05735	COG1773	rubredoxin
C1C92_05740	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C92_05750	COG0348	domain, Protein
C1C92_05760	COG3033	Beta-eliminating lyase
C1C92_05765	COG0814	amino acid
C1C92_05770	COG0814	amino acid
C1C92_05790	COG5001	Diguanylate cyclase
C1C92_05790	COG3706	GGDEF domain
C1C92_05790	COG4251	negative regulation of phosphorylation
C1C92_05790	COG2203	Gaf domain
C1C92_05800	COG1609	Transcriptional regulator
C1C92_05840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_05855	COG2960	long-chain fatty acid transporting porin activity
C1C92_05865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1C92_05880	COG3118	belongs to the thioredoxin family
C1C92_05885	COG0513	Belongs to the DEAD box helicase family
C1C92_05890	COG0248	Ppx GppA phosphatase
C1C92_05900	COG0742	ribosomal rna small subunit methyltransferase
C1C92_05920	COG0084	hydrolase, TatD family'
C1C92_05925	COG0805	protein transport
C1C92_05930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_05935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_05940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1C92_05945	COG3165	ubiquinone biosynthetic process from chorismate
C1C92_05955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1C92_05960	COG0402	S-adenosylhomocysteine deaminase activity
C1C92_05995	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1C92_06000	COG0848	biopolymer transport protein
C1C92_06005	COG0811	peptide transport
C1C92_06010	COG0811	peptide transport
C1C92_06020	COG2771	luxR family
C1C92_06025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1C92_06030	COG1349	DNA-binding transcription factor activity
C1C92_06035	COG0745	RESPONSE REGULATOR receiver
C1C92_06040	COG2205	protein histidine kinase activity
C1C92_06050	COG4452	Inner membrane protein CreD
C1C92_06055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1C92_06060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1C92_06065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1C92_06070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1C92_06075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1C92_06080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1C92_06085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1C92_06095	COG0356	it plays a direct role in the translocation of protons across the membrane
C1C92_06105	COG1475	DNA binding
C1C92_06110	COG1192	Involved in chromosome partitioning
C1C92_06115	COG0357	Ribosomal RNA small subunit methyltransferase G
C1C92_06120	COG0445	tRNA wobble uridine modification
C1C92_06125	COG0716	FMN binding
C1C92_06135	COG4615	Cyclic peptide transporter
C1C92_06140	COG1120	ATPase activity
C1C92_06145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C92_06155	COG3550	peptidyl-serine autophosphorylation
C1C92_06215	COG1695	Transcriptional regulator
C1C92_06250	COG3173	Aminoglycoside phosphotransferase
C1C92_06365	COG4974	Belongs to the 'phage' integrase family
C1C92_06370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1C92_06375	COG0706	membrane insertase activity
C1C92_06380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1C92_06385	COG0594	ribonuclease P activity
C1C92_06390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1C92_06410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1C92_06415	COG0592	DNA-directed DNA polymerase activity
C1C92_06425	COG0187	DNA topoisomerase II activity
C1C92_06430	COG2207	Transcriptional regulator
C1C92_06435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1C92_06440	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C92_06445	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C92_06450	COG3977	Valine--pyruvate aminotransferase
C1C92_06465	COG2814	Major facilitator Superfamily
C1C92_06470	COG0745	RESPONSE REGULATOR receiver
C1C92_06475	COG2205	protein histidine kinase activity
C1C92_06505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C92_06510	COG4191	Histidine kinase
C1C92_06510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_06515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_06520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_06525	COG1309	transcriptional regulator
C1C92_06555	COG0561	phosphatase activity
C1C92_06560	COG2267	carboxylic ester hydrolase activity
C1C92_06565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C92_06570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C92_06575	COG1758	RNA polymerase activity
C1C92_06590	COG0859	PFAM glycosyl transferase family 9
C1C92_06595	COG3642	lipopolysaccharide core region biosynthetic process
C1C92_06635	COG0589	response to stress
C1C92_06645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C92_06650	COG3706	GGDEF domain
C1C92_06655	COG1528	Iron-storage protein
C1C92_06660	COG2081	HI0933 family
C1C92_06665	COG2223	nitrite transmembrane transporter activity
C1C92_06670	COG1280	lysine exporter protein (LysE YggA)
C1C92_06680	COG3188	usher protein
C1C92_06700	COG2205	protein histidine kinase activity
C1C92_06700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_06710	COG3275	phosphorelay sensor kinase activity
C1C92_06715	COG3279	Response regulator of the LytR AlgR family
C1C92_06720	COG2223	nitrite transmembrane transporter activity
C1C92_06725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1C92_06730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1C92_06775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1C92_06780	COG2166	iron-sulfur cluster assembly
C1C92_06785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1C92_06805	COG1063	alcohol dehydrogenase
C1C92_06810	COG0156	8-amino-7-oxononanoate synthase activity
C1C92_06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C92_06865	COG1609	Transcriptional regulator
C1C92_06885	COG1580	Controls the rotational direction of flagella during chemotaxis
C1C92_06890	COG3161	chorismate lyase activity
C1C92_06895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1C92_06900	COG2937	Belongs to the GPAT DAPAT family
C1C92_06905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C92_06920	COG0534	Mate efflux family protein
C1C92_06925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1C92_06930	COG2205	protein histidine kinase activity
C1C92_06935	COG0745	RESPONSE REGULATOR receiver
C1C92_06945	COG1045	serine acetyltransferase
C1C92_06960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1C92_06965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_06965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_06970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1C92_07010	COG1609	Transcriptional regulator
C1C92_07015	COG3250	beta-galactosidase activity
C1C92_07020	COG2731	YhcH YjgK YiaL family protein
C1C92_07025	COG0531	amino acid
C1C92_07030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_07035	COG0531	amino acid
C1C92_07040	COG0385	Bile acid
C1C92_07045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1C92_07070	COG0583	DNA-binding transcription factor activity
C1C92_07095	COG0210	DNA helicase
C1C92_07110	COG1943	Transposase
C1C92_07115	COG0583	DNA-binding transcription factor activity
C1C92_07150	COG0583	DNA-binding transcription factor activity
C1C92_07165	COG1280	lysine exporter protein (LysE YggA)
C1C92_07175	COG2962	Rard protein
C1C92_07180	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_07185	COG1396	sequence-specific DNA binding
C1C92_07200	COG0519	Catalyzes the synthesis of GMP from XMP
C1C92_07200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C92_07210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_07230	COG1322	Protein conserved in bacteria
C1C92_07235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_07240	COG0569	domain protein
C1C92_07245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_07245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_07250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1C92_07255	COG0242	peptide deformylase activity
C1C92_07265	COG0758	DNA mediated transformation
C1C92_07270	COG2922	Belongs to the Smg family
C1C92_07275	COG0551	DNA topoisomerase type I activity
C1C92_07280	COG0009	L-threonylcarbamoyladenylate synthase
C1C92_07285	COG0408	coproporphyrinogen oxidase activity
C1C92_07290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1C92_07300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1C92_07310	COG3078	GTPase activator activity
C1C92_07320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C92_07325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C92_07335	COG3852	Histidine kinase
C1C92_07345	COG0174	glutamine synthetase
C1C92_07355	COG1295	ribonuclease BN
C1C92_07360	COG1490	D-aminoacyl-tRNA deacylase activity
C1C92_07370	COG0456	acetyltransferase
C1C92_07380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1C92_07385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C92_07390	COG2610	gluconate transmembrane transporter activity
C1C92_07395	COG3265	gluconokinase activity
C1C92_07400	COG0129	dihydroxy-acid dehydratase activity
C1C92_07405	COG0800	Aldolase
C1C92_07420	COG1609	Transcriptional regulator
C1C92_07430	COG4942	peptidase
C1C92_07435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1C92_07440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_07445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1C92_07450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1C92_07455	COG0316	Belongs to the HesB IscA family
C1C92_07455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1C92_07460	COG1040	competence protein
C1C92_07465	COG0596	Alpha beta hydrolase
C1C92_07480	COG2183	response to ionizing radiation
C1C92_07485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C92_07490	COG0745	RESPONSE REGULATOR receiver
C1C92_07495	COG2205	protein histidine kinase activity
C1C92_07505	COG0051	transcription antitermination factor activity, RNA binding
C1C92_07510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1C92_07515	COG0088	Forms part of the polypeptide exit tunnel
C1C92_07520	COG0089	rRNA binding
C1C92_07525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1C92_07530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1C92_07535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1C92_07540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1C92_07545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1C92_07550	COG0255	Belongs to the universal ribosomal protein uL29 family
C1C92_07555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1C92_07560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1C92_07565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1C92_07570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1C92_07575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1C92_07580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1C92_07585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1C92_07590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1C92_07595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1C92_07600	COG1841	ribosomal large subunit assembly
C1C92_07605	COG0200	Binds to the 23S rRNA
C1C92_07610	COG0201	protein transport
C1C92_07615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C92_07620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1C92_07625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1C92_07630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1C92_07635	COG0202	RNA polymerase activity
C1C92_07640	COG0203	ribosomal protein L17
C1C92_07700	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1C92_07705	COG0583	DNA-binding transcription factor activity
C1C92_07710	COG4221	oxidoreductase activity
C1C92_07725	COG1770	oligopeptidase
C1C92_07730	COG2358	TRAP transporter, solute receptor (TAXI family
C1C92_07745	COG3714	YhhN family
C1C92_07760	COG0583	DNA-binding transcription factor activity
C1C92_07770	COG1301	dicarboxylic acid transport
C1C92_07780	COG2095	MarC family integral membrane protein
C1C92_07790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_07800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C92_07805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C92_07830	COG0742	ribosomal rna small subunit methyltransferase
C1C92_07835	COG0552	protein localization to endoplasmic reticulum
C1C92_07840	COG2884	Cell division ATP-binding protein ftsE
C1C92_07845	COG2177	Part of the ABC transporter FtsEX involved in
C1C92_07855	COG0288	reversible hydration of carbon dioxide
C1C92_07860	COG2188	Transcriptional regulator
C1C92_07865	COG1228	amidohydrolase
C1C92_07870	COG0010	Belongs to the arginase family
C1C92_07875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1C92_07880	COG2986	histidine ammonia-lyase
C1C92_07885	COG0387	Pfam Sodium calcium exchanger
C1C92_07890	COG2200	EAL domain
C1C92_07945	COG1459	type II secretion system
C1C92_07990	COG1077	Cell shape determining protein MreB Mrl
C1C92_07995	COG1792	Involved in formation and maintenance of cell shape
C1C92_08000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1C92_08005	COG0424	maF-like protein
C1C92_08010	COG1530	ribonuclease E activity
C1C92_08020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_08040	COG0477	Major facilitator Superfamily
C1C92_08050	COG2321	neutral zinc metallopeptidase
C1C92_08085	COG0189	ligase activity
C1C92_08090	COG0642	Histidine kinase
C1C92_08095	COG0745	RESPONSE REGULATOR receiver
C1C92_08110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1C92_08115	COG0352	thiamine-phosphate diphosphorylase activity
C1C92_08120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C92_08130	COG2022	thiamine diphosphate biosynthetic process
C1C92_08135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1C92_08155	COG0110	maltose O-acetyltransferase activity
C1C92_08170	COG3932	Exopolysaccharide synthesis, ExoD
C1C92_08185	COG1733	regulation of RNA biosynthetic process
C1C92_08210	COG2226	methyltransferase
C1C92_08220	COG1494	fructose-1,6-bisphosphatase
C1C92_08230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1C92_08235	COG5007	Belongs to the BolA IbaG family
C1C92_08245	COG2854	intermembrane phospholipid transfer
C1C92_08250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C92_08255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1C92_08260	COG1127	ABC transporter
C1C92_08265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1C92_08265	COG0517	IMP dehydrogenase activity
C1C92_08270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1C92_08280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1C92_08285	COG1137	ATPase activity
C1C92_08290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1C92_08300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_08305	COG1660	Displays ATPase and GTPase activities
C1C92_08310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_08330	COG3964	amidohydrolase
C1C92_08360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C92_08365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C92_08375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1C92_08380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1C92_08385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1C92_08390	COG0723	plastoquinol--plastocyanin reductase activity
C1C92_08395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1C92_08400	COG2857	Cytochrome c1
C1C92_08405	COG0625	glutathione transferase activity
C1C92_08410	COG2969	positive regulation of protein catabolic process
C1C92_08415	COG2823	Periplasmic or secreted lipoprotein
C1C92_08420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C92_08425	COG0792	nuclease activity
C1C92_08430	COG3107	peptidoglycan biosynthetic process
C1C92_08435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1C92_08445	COG2001	Belongs to the MraZ family
C1C92_08450	COG0275	rRNA processing
C1C92_08455	COG3116	cell division
C1C92_08460	COG0768	penicillin binding
C1C92_08465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1C92_08470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1C92_08475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_08480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1C92_08485	COG0772	Belongs to the SEDS family
C1C92_08490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1C92_08495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C92_08500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1C92_08505	COG0849	cell division
C1C92_08510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1C92_08515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1C92_08525	COG0653	protein targeting
C1C92_08535	COG0494	nUDIX hydrolase
C1C92_08540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1C92_08545	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1C92_08560	COG1459	type II secretion system
C1C92_08565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C92_08590	COG2186	Transcriptional regulator
C1C92_08595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1C92_08600	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C92_08605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C92_08615	COG0840	transmembrane signaling receptor activity
C1C92_08620	COG0840	transmembrane signaling receptor activity
C1C92_08630	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1C92_08635	COG2200	EAL domain
C1C92_08645	COG1280	lysine exporter protein (LysE YggA)
C1C92_08655	COG0523	cobalamin synthesis protein
C1C92_08660	COG0477	Major facilitator Superfamily
C1C92_08675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1C92_08680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1C92_08725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1C92_08745	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C92_08750	COG0732	type I restriction modification DNA specificity domain
C1C92_08755	COG1401	restriction endodeoxyribonuclease activity
C1C92_08755	COG1401	restriction endodeoxyribonuclease activity
C1C92_08765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_08800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_08815	COG1546	Belongs to the CinA family
C1C92_08820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1C92_08825	COG2137	regulation of response to DNA damage stimulus
C1C92_08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1C92_08835	COG0527	aspartate kinase activity
C1C92_08840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1C92_08875	COG1686	Belongs to the peptidase S11 family
C1C92_08880	COG0586	Pfam SNARE associated Golgi protein
C1C92_08885	COG1253	flavin adenine dinucleotide binding
C1C92_08890	COG0525	valine-tRNA ligase activity
C1C92_08895	COG2927	DNA polymerase III (CHI subunit)
C1C92_08900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_08905	COG0795	lipopolysaccharide-transporting ATPase activity
C1C92_08910	COG0795	lipopolysaccharide-transporting ATPase activity
C1C92_08930	COG0004	ammonium transporteR
C1C92_08935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_08945	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1C92_08950	COG0084	hydrolase, TatD family'
C1C92_08955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_08965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1C92_08970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1C92_08975	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1C92_08980	COG0813	purine-nucleoside phosphorylase activity
C1C92_08985	COG3447	MASE1 domain protein
C1C92_08985	COG5001	Diguanylate cyclase
C1C92_08985	COG5002	protein histidine kinase activity
C1C92_08995	COG0560	Phosphoserine phosphatase
C1C92_09010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1C92_09020	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1C92_09025	COG0776	regulation of translation
C1C92_09040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C92_09045	COG0735	belongs to the Fur family
C1C92_09065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1C92_09070	COG0513	Belongs to the DEAD box helicase family
C1C92_09075	COG3022	response to hydroperoxide
C1C92_09080	COG2805	Type II/IV secretion system protein
C1C92_09090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1C92_09095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1C92_09100	COG0762	integral membrane protein
C1C92_09105	COG1872	DUF167
C1C92_09125	COG3112	Uncharacterised protein family (UPF0231)
C1C92_09130	COG3835	regulator
C1C92_09135	COG2610	gluconate transmembrane transporter activity
C1C92_09140	COG1929	Belongs to the glycerate kinase type-1 family
C1C92_09155	COG0583	DNA-binding transcription factor activity
C1C92_09160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_09175	COG0347	Belongs to the P(II) protein family
C1C92_09180	COG1840	ABC-type Fe3 transport system, periplasmic component
C1C92_09190	COG3842	ATPase activity
C1C92_09195	COG2837	iron assimilation
C1C92_09200	COG1438	arginine binding
C1C92_09205	COG1126	abc transporter atp-binding protein
C1C92_09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_09215	COG4215	(ABC) transporter
C1C92_09220	COG4160	amino acid transport
C1C92_09225	COG0039	L-malate dehydrogenase activity
C1C92_09230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1C92_09235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_09235	COG1017	nitric oxide dioxygenase activity
C1C92_09245	COG4536	flavin adenine dinucleotide binding
C1C92_09250	COG4137	Cytochrome C assembly protein
C1C92_09255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1C92_09260	COG0228	four-way junction DNA binding
C1C92_09265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1C92_09270	COG0336	Belongs to the RNA methyltransferase TrmD family
C1C92_09275	COG0335	large ribosomal subunit rRNA binding
C1C92_09290	COG1051	belongs to the nudix hydrolase family
C1C92_09300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1C92_09305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1C92_09310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C92_09320	COG0583	DNA-binding transcription factor activity
C1C92_09325	COG0640	Transcriptional regulator
C1C92_09330	COG0268	Binds directly to 16S ribosomal RNA
C1C92_09335	COG0728	peptidoglycan biosynthetic process
C1C92_09340	COG0196	riboflavin kinase activity
C1C92_09345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1C92_09350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1C92_09355	COG1047	Peptidyl-prolyl cis-trans
C1C92_09360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1C92_09365	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1C92_09400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1C92_09400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_09415	COG1854	S-ribosylhomocysteine lyase activity
C1C92_09420	COG3706	GGDEF domain
C1C92_09425	COG0557	exoribonuclease II activity
C1C92_09430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C92_09440	COG2153	protein acetylation
C1C92_09450	COG1914	H( )-stimulated, divalent metal cation uptake system
C1C92_09455	COG0360	Binds together with S18 to 16S ribosomal RNA
C1C92_09460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1C92_09465	COG0359	binds to the 23S rRNA
C1C92_09505	COG1238	metal cluster binding
C1C92_09510	COG0612	Peptidase, M16
C1C92_09515	COG2918	glutathione biosynthetic process
C1C92_09520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C92_09525	COG1027	Aspartate ammonia-lyase
C1C92_09530	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1C92_09535	COG0534	Mate efflux family protein
C1C92_09540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1C92_09545	COG0459	protein refolding
C1C92_09565	COG0564	pseudouridine synthase activity
C1C92_09570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1C92_09600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1C92_09610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1C92_09615	COG4208	sulfate ABC transporter
C1C92_09620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1C92_09625	COG0583	DNA-binding transcription factor activity
C1C92_09630	COG3397	chitin binding
C1C92_09635	COG0840	transmembrane signaling receptor activity
C1C92_09660	COG1328	CTP reductase activity
C1C92_09665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C92_09680	COG1448	Aminotransferase
C1C92_09705	COG1215	transferase activity, transferring glycosyl groups
C1C92_09715	COG3118	belongs to the thioredoxin family
C1C92_09715	COG0457	Tetratricopeptide repeat
C1C92_09755	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C1C92_09760	COG0513	Belongs to the DEAD box helicase family
C1C92_09765	COG0840	transmembrane signaling receptor activity
C1C92_09775	COG4166	transmembrane transport
C1C92_09790	COG1024	Enoyl-CoA hydratase
C1C92_09805	COG4221	oxidoreductase activity
C1C92_09810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_09815	COG0442	prolyl-tRNA aminoacylation
C1C92_09820	COG0840	transmembrane signaling receptor activity
C1C92_09825	COG0632	four-way junction helicase activity
C1C92_09830	COG2255	four-way junction helicase activity
C1C92_09840	COG1271	oxidase subunit
C1C92_09845	COG1294	oxidase, subunit
C1C92_09850	COG4890	Cyd operon protein YbgT
C1C92_09855	COG3790	cyd operon protein YbgE
C1C92_09860	COG0824	Thioesterase
C1C92_09865	COG0811	peptide transport
C1C92_09880	COG0823	Involved in the tonB-independent uptake of proteins
C1C92_09885	COG2885	chlorophyll binding
C1C92_09890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1C92_09965	COG0840	transmembrane signaling receptor activity
C1C92_09970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1C92_09980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C92_09985	COG1640	4-alpha-glucanotransferase
C1C92_09990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1C92_10020	COG2130	NADP-dependent
C1C92_10025	COG1846	Transcriptional regulator
C1C92_10055	COG0561	phosphatase activity
C1C92_10070	COG0733	neurotransmitter:sodium symporter activity
C1C92_10075	COG0733	neurotransmitter:sodium symporter activity
C1C92_10090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_10105	COG1794	racemase activity, acting on amino acids and derivatives
C1C92_10115	COG1022	Amp-dependent synthetase and ligase
C1C92_10125	COG0456	acetyltransferase
C1C92_10140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1C92_10145	COG5001	Diguanylate cyclase
C1C92_10145	COG5002	protein histidine kinase activity
C1C92_10170	COG0456	acetyltransferase
C1C92_10190	COG2957	Belongs to the agmatine deiminase family
C1C92_10195	COG0154	amidase activity
C1C92_10230	COG2207	Transcriptional regulator
C1C92_10230	COG1917	Cupin 2, conserved barrel domain protein
C1C92_10240	COG0513	Belongs to the DEAD box helicase family
C1C92_10245	COG2199	diguanylate cyclase activity
C1C92_10245	COG2203	Gaf domain
C1C92_10280	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C1C92_10290	COG1136	(ABC) transporter
C1C92_10290	COG0577	efflux transmembrane transporter activity
C1C92_10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_10300	COG0745	RESPONSE REGULATOR receiver
C1C92_10305	COG2205	protein histidine kinase activity
C1C92_10360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_10370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1C92_10375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1C92_10380	COG1178	ABC-type Fe3 transport system permease component
C1C92_10385	COG4143	(ABC) transporter
C1C92_10400	COG0066	3-isopropylmalate dehydratase activity
C1C92_10405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1C92_10410	COG0473	3-isopropylmalate dehydrogenase activity
C1C92_10415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C92_10425	COG0671	phosphoesterase, PA-phosphatase related
C1C92_10440	COG0028	Belongs to the TPP enzyme family
C1C92_10445	COG0440	acetolactate synthase activity
C1C92_10450	COG0280	phosphate acetyltransferase
C1C92_10450	COG0857	belongs to the CobB CobQ family
C1C92_10455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1C92_10460	COG3092	negative regulation of chromosome organization
C1C92_10465	COG3013	Belongs to the UPF0304 family
C1C92_10470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1C92_10475	COG2716	regulation of RNA biosynthetic process
C1C92_10480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C92_10485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1C92_10490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1C92_10505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1C92_10525	COG2198	Histidine kinase
C1C92_10525	COG5002	protein histidine kinase activity
C1C92_10525	COG0784	Response regulator, receiver
C1C92_10530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1C92_10550	COG0840	transmembrane signaling receptor activity
C1C92_10560	COG1464	Belongs to the NlpA lipoprotein family
C1C92_10565	COG2011	ABC-type metal ion transport system permease component
C1C92_10570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1C92_10590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1C92_10590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1C92_10595	COG0802	atpase or kinase
C1C92_10605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1C92_10610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1C92_10615	COG1923	regulation of RNA biosynthetic process
C1C92_10620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1C92_10625	COG0330	HflC and HflK could
C1C92_10630	COG0330	HflC and HflK could
C1C92_10635	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1C92_10640	COG0142	geranyltranstransferase activity
C1C92_10645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1C92_10650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1C92_10655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1C92_10665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C92_10670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1C92_10680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1C92_10685	COG2967	ApaG domain
C1C92_10690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1C92_10705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1C92_10710	COG3178	'Phosphotransferase
C1C92_10715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1C92_10720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C92_10725	COG2252	PERMEase
C1C92_10735	COG0488	(ABC) transporter
C1C92_10740	COG0582	viral genome integration into host DNA
C1C92_10895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_10900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C92_10905	COG2135	peptidase activity
C1C92_10950	COG4626	Terminase
C1C92_10950	COG1802	Transcriptional regulator
C1C92_10965	COG0616	signal peptide processing
C1C92_11070	COG0741	lytic transglycosylase activity
C1C92_11075	COG0463	Glycosyl transferase, family 2
C1C92_11085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1C92_11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_11120	COG3721	Heme iron utilization protein
C1C92_11125	COG0748	coenzyme F420 binding
C1C92_11150	COG2814	Major facilitator Superfamily
C1C92_11155	COG2205	protein histidine kinase activity
C1C92_11155	COG2202	Pas domain
C1C92_11165	COG2226	methyltransferase
C1C92_11175	COG1765	OsmC-like protein
C1C92_11190	COG3954	Phosphoribulokinase
C1C92_11195	COG3089	Belongs to the UPF0270 family
C1C92_11200	COG3706	GGDEF domain
C1C92_11200	COG2203	Gaf domain
C1C92_11200	COG5001	Diguanylate cyclase
C1C92_11200	COG4251	negative regulation of phosphorylation
C1C92_11205	COG0429	hydrolase of the alpha beta-hydrolase fold
C1C92_11210	COG0784	Response regulator, receiver
C1C92_11210	COG0835	chemotaxis
C1C92_11220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1C92_11225	COG1047	Peptidyl-prolyl cis-trans
C1C92_11230	COG2900	Belongs to the SlyX family
C1C92_11240	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C92_11245	COG2204	response regulator
C1C92_11265	COG0737	Belongs to the 5'-nucleotidase family
C1C92_11280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_11285	COG0506	proline dehydrogenase activity
C1C92_11285	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C92_11285	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C92_11295	COG0114	fumarate hydratase activity
C1C92_11305	COG1566	PFAM secretion protein HlyD family protein
C1C92_11385	COG1280	lysine exporter protein (LysE YggA)
C1C92_11390	COG0826	peptidase U32
C1C92_11400	COG3813	Protein conserved in bacteria
C1C92_11420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1C92_11445	COG0300	oxidoreductase activity
C1C92_11465	COG2610	gluconate transmembrane transporter activity
C1C92_11470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C92_11475	COG3622	Belongs to the hyi family
C1C92_11480	COG0235	Class ii aldolase
C1C92_11490	COG2084	Dehydrogenase
C1C92_11495	COG1349	DNA-binding transcription factor activity
C1C92_11505	COG2133	pyrroloquinoline quinone binding
C1C92_11540	COG4397	Mu-like prophage major head subunit gpT
C1C92_11570	COG0077	Prephenate dehydratase
C1C92_11570	COG1605	Chorismate mutase
C1C92_11595	COG3272	Protein of unknown function (DUF1722)
C1C92_11600	COG0789	Transcriptional regulator
C1C92_11605	COG0415	Belongs to the DNA photolyase family
C1C92_11615	COG4221	oxidoreductase activity
C1C92_11630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1C92_11655	COG0783	Belongs to the Dps family
C1C92_11660	COG1151	hydroxylamine reductase activity
C1C92_11665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_11670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_11690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_11705	COG5002	protein histidine kinase activity
C1C92_11705	COG5000	phosphorelay sensor kinase activity
C1C92_11715	COG0659	secondary active sulfate transmembrane transporter activity
C1C92_11725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1C92_11730	COG1666	GTP binding
C1C92_11740	COG2211	Major facilitator Superfamily
C1C92_11750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C92_11760	COG2813	Specifically methylates the guanine in position
C1C92_11765	COG0271	Belongs to the BolA IbaG family
C1C92_11770	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_11775	COG1805	sodium ion transport
C1C92_11780	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_11785	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_11790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_11795	COG2871	sodium ion transport
C1C92_11800	COG1477	protein flavinylation
C1C92_11815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_11820	COG0840	transmembrane signaling receptor activity
C1C92_11825	COG0583	DNA-binding transcription factor activity
C1C92_11840	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1C92_11850	COG0473	3-isopropylmalate dehydrogenase activity
C1C92_11855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_11860	COG1611	Belongs to the LOG family
C1C92_11865	COG3706	GGDEF domain
C1C92_11875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C92_11875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C92_11885	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1C92_11910	COG3098	single-species biofilm formation
C1C92_11915	COG0564	pseudouridine synthase activity
C1C92_11925	COG4580	involved in the transport of maltose and maltodextrins
C1C92_11935	COG1263	PTS System
C1C92_11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_11945	COG2171	N-acyltransferase activity
C1C92_11950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1C92_11955	COG0024	Methionine aminopeptidase
C1C92_11960	COG0052	Belongs to the universal ribosomal protein uS2 family
C1C92_11965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1C92_11970	COG0528	UMP kinase activity
C1C92_11975	COG0233	cytoplasmic translational termination
C1C92_11980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1C92_11985	COG0575	Belongs to the CDS family
C1C92_11990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1C92_11995	COG0750	zinc metalloprotease
C1C92_12010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_12015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C92_12020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_12025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_12030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1C92_12035	COG0587	DNA-directed DNA polymerase activity
C1C92_12040	COG0825	malonyl-CoA metabolic process
C1C92_12055	COG0814	amino acid
C1C92_12060	COG0531	amino acid
C1C92_12070	COG0488	(ABC) transporter
C1C92_12080	COG3590	peptidase
C1C92_12085	COG0037	tRNA processing
C1C92_12090	COG3706	GGDEF domain
C1C92_12135	COG0366	Alpha amylase catalytic
C1C92_12150	COG0463	Glycosyl transferase, family 2
C1C92_12165	COG2989	Protein conserved in bacteria
C1C92_12170	COG3108	Peptidase M15
C1C92_12180	COG2860	membrane
C1C92_12195	COG3115	cell septum assembly
C1C92_12200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1C92_12210	COG1328	CTP reductase activity
C1C92_12215	COG0602	queuosine metabolic process
C1C92_12240	COG1566	PFAM secretion protein HlyD family protein
C1C92_12250	COG3290	protein histidine kinase activity
C1C92_12265	COG0667	Aldo Keto reductase
C1C92_12275	COG0697	spore germination
C1C92_12285	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_12290	COG3284	Transcriptional regulator
C1C92_12295	COG3706	GGDEF domain
C1C92_12300	COG0346	lactoylglutathione lyase activity
C1C92_12305	COG0745	RESPONSE REGULATOR receiver
C1C92_12310	COG5002	protein histidine kinase activity
C1C92_12320	COG4783	chaperone-mediated protein folding
C1C92_12340	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C92_12345	COG1131	(ABC) transporter
C1C92_12350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1C92_12360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_12365	COG4597	amino acid ABC transporter
C1C92_12370	COG0765	amino acid transport
C1C92_12375	COG1126	abc transporter atp-binding protein
C1C92_12385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1C92_12390	COG0678	peroxiredoxin activity
C1C92_12400	COG0019	diaminopimelate decarboxylase activity
C1C92_12405	COG1115	amino acid carrier protein
C1C92_12410	COG0095	Lipoate-protein ligase
C1C92_12415	COG2233	PERMEase
C1C92_12435	COG2207	Transcriptional regulator
C1C92_12440	COG0281	malic enzyme
C1C92_12470	COG0733	neurotransmitter:sodium symporter activity
C1C92_12475	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1C92_12480	COG3706	GGDEF domain
C1C92_12490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_12495	COG1032	radical SAM domain protein
C1C92_12500	COG2319	Wd-40 repeat
C1C92_12500	COG3903	Transcriptional regulator
C1C92_12520	COG0673	inositol 2-dehydrogenase activity
C1C92_12525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1C92_12530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1C92_12560	COG1196	nuclear chromosome segregation
C1C92_12560	COG0739	heme binding
C1C92_12560	COG0741	lytic transglycosylase activity
C1C92_12585	COG0788	formyltetrahydrofolate deformylase activity
C1C92_12590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C92_12600	COG3118	belongs to the thioredoxin family
C1C92_12610	COG0791	NLP P60 protein
C1C92_12615	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1C92_12630	COG1376	ErfK ybiS ycfS ynhG family protein
C1C92_12630	COG1388	LysM domain
C1C92_12690	COG0583	DNA-binding transcription factor activity
C1C92_12720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1C92_12795	COG1203	CRISPR-associated helicase, Cas3
C1C92_12800	COG1518	maintenance of DNA repeat elements
C1C92_12835	COG2003	Belongs to the UPF0758 family
C1C92_12880	COG3311	Transcriptional regulator
C1C92_12895	COG0582	viral genome integration into host DNA
C1C92_12900	COG2205	protein histidine kinase activity
C1C92_12900	COG0784	Response regulator, receiver
C1C92_12925	COG2205	protein histidine kinase activity
C1C92_12925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_12930	COG3384	dioxygenase
C1C92_12940	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1C92_12950	COG0531	amino acid
C1C92_12955	COG0531	amino acid
C1C92_12970	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_12975	COG1917	Cupin 2, conserved barrel domain protein
C1C92_12975	COG1396	sequence-specific DNA binding
C1C92_12980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_13015	COG4651	solute:proton antiporter activity
C1C92_13015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1C92_13030	COG2974	May be involved in recombination
C1C92_13040	COG0420	3'-5' exonuclease activity
C1C92_13050	COG3038	cytochrome b561
C1C92_13055	COG2190	(PTS) system
C1C92_13065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_13070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1C92_13075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1C92_13090	COG1720	tRNA m6t6A37 methyltransferase activity
C1C92_13110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1C92_13115	COG4988	ABC transporter
C1C92_13130	COG0745	RESPONSE REGULATOR receiver
C1C92_13140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C92_13155	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1C92_13160	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1C92_13175	COG0083	homoserine kinase activity
C1C92_13180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C92_13200	COG1943	Transposase
C1C92_13210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1C92_13220	COG3220	belongs to the UPF0276 family
C1C92_13255	COG1289	transmembrane transporter activity
C1C92_13265	COG0746	molybdenum cofactor guanylyltransferase activity
C1C92_13300	COG3264	Mechanosensitive ion channel
C1C92_13300	COG1196	nuclear chromosome segregation
C1C92_13310	COG2850	peptidyl-arginine hydroxylation
C1C92_13315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1C92_13320	COG2915	High frequency lysogenization protein hflD homolog
C1C92_13325	COG0482	sulfurtransferase activity
C1C92_13335	COG1187	pseudouridine synthase activity
C1C92_13340	COG0456	acetyltransferase
C1C92_13370	COG0538	isocitrate dehydrogenase activity
C1C92_13380	COG3048	D-serine ammonia-lyase activity
C1C92_13385	COG0583	DNA-binding transcription factor activity
C1C92_13390	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_13395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_13400	COG2375	cellular response to nickel ion
C1C92_13405	COG1538	Outer membrane efflux protein
C1C92_13410	COG1136	(ABC) transporter
C1C92_13410	COG0577	efflux transmembrane transporter activity
C1C92_13415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_13425	COG0497	DNA recombination
C1C92_13435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1C92_13440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1C92_13445	COG0443	Heat shock 70 kDa protein
C1C92_13450	COG0484	heat shock protein binding
C1C92_13480	COG1285	pathogenesis
C1C92_13490	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C92_13500	COG0640	Transcriptional regulator
C1C92_13530	COG0095	Lipoate-protein ligase
C1C92_13545	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_13550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_13560	COG0708	Exodeoxyribonuclease III
C1C92_13570	COG0745	RESPONSE REGULATOR receiver
C1C92_13585	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C1C92_13600	COG1846	Transcriptional regulator
C1C92_13620	COG0583	DNA-binding transcription factor activity
C1C92_13625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C92_13630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C92_13640	COG1845	cytochrome c oxidase, subunit III
C1C92_13645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1C92_13650	COG0109	protoheme IX farnesyltransferase activity
C1C92_13660	COG2814	Major facilitator Superfamily
C1C92_13665	COG5507	3-demethylubiquinone-9 3-methyltransferase
C1C92_13675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1C92_13680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C1C92_13685	COG4521	taurine ABC transporter
C1C92_13720	COG1988	membrane-bound metal-dependent
C1C92_13745	COG0133	tryptophan synthase activity
C1C92_13750	COG0135	phosphoribosylanthranilate isomerase activity
C1C92_13750	COG0134	indole-3-glycerol-phosphate synthase activity
C1C92_13755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C92_13760	COG0512	Glutamine amidotransferase of anthranilate synthase
C1C92_13760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C92_13765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1C92_13770	COG0613	PHP domain protein
C1C92_13775	COG0009	L-threonylcarbamoyladenylate synthase
C1C92_13785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1C92_13800	COG1946	Acyl-CoA thioesterase
C1C92_13815	COG1309	transcriptional regulator
C1C92_13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_13825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_13840	COG3039	Transposase
C1C92_13890	COG2003	Belongs to the UPF0758 family
C1C92_13905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C92_13920	COG0583	DNA-binding transcription factor activity
C1C92_13925	COG4584	PFAM Integrase catalytic
C1C92_13930	COG1484	DNA-dependent DNA replication
C1C92_13965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1C92_13975	COG1960	acyl-CoA dehydrogenase activity
C1C92_13980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_13990	COG0469	pyruvate kinase activity
C1C92_13995	COG1737	Transcriptional regulator
C1C92_14010	COG0745	RESPONSE REGULATOR receiver
C1C92_14020	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1C92_14060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1C92_14060	COG2755	lipolytic protein G-D-S-L family
C1C92_14075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_14095	COG2244	polysaccharide biosynthetic process
C1C92_14110	COG0463	Glycosyl transferase, family 2
C1C92_14115	COG2801	Transposase and inactivated derivatives
C1C92_14125	COG0438	transferase activity, transferring glycosyl groups
C1C92_14130	COG1216	Glycosyl transferase, family 2
C1C92_14130	COG1442	glycosyl transferase family 8
C1C92_14140	COG0438	transferase activity, transferring glycosyl groups
C1C92_14145	COG1596	polysaccharide export
C1C92_14150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1C92_14155	COG0489	protein tyrosine kinase activity
C1C92_14155	COG3206	protein involved in exopolysaccharide biosynthesis
C1C92_14175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_14185	COG3132	Protein of unknown function, DUF480
C1C92_14210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1C92_14225	COG1278	Cold shock
C1C92_14255	COG0697	spore germination
C1C92_14265	COG0675	Transposase, IS605 OrfB family
C1C92_14270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C92_14285	COG4166	transmembrane transport
C1C92_14295	COG0675	Transposase, IS605 OrfB family
C1C92_14300	COG0622	Phosphoesterase
C1C92_14315	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1C92_14320	COG0784	Response regulator, receiver
C1C92_14320	COG0835	chemotaxis
C1C92_14325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1C92_14330	COG1815	bacterial-type flagellum-dependent cell motility
C1C92_14345	COG4786	Flagellar basal body rod
C1C92_14360	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1C92_14365	COG1706	bacterial-type flagellum-dependent cell motility
C1C92_14385	COG2239	Acts as a magnesium transporter
C1C92_14395	COG0675	Transposase, IS605 OrfB family
C1C92_14410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1C92_14415	COG2716	regulation of RNA biosynthetic process
C1C92_14430	COG3852	Histidine kinase
C1C92_14440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1C92_14445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1C92_14450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1C92_14455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1C92_14475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1C92_14490	COG0590	tRNA wobble adenosine to inosine editing
C1C92_14495	COG0573	inorganic phosphate transmembrane transporter activity
C1C92_14500	COG0581	inorganic phosphate transmembrane transporter activity
C1C92_14510	COG0704	Plays a role in the regulation of phosphate uptake
C1C92_14515	COG1253	flavin adenine dinucleotide binding
C1C92_14530	COG0531	amino acid
C1C92_14545	COG1126	abc transporter atp-binding protein
C1C92_14550	COG0765	amino acid transport
C1C92_14555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_14565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C92_14585	COG1785	Belongs to the alkaline phosphatase family
C1C92_14590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1C92_14595	COG0477	Major facilitator Superfamily
C1C92_14600	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1C92_14610	COG1199	ATP-dependent helicase activity
C1C92_14625	COG1448	Aminotransferase
C1C92_14630	COG0433	COG0433 Predicted ATPase
C1C92_14650	COG1132	(ABC) transporter
C1C92_14655	COG1663	tetraacyldisaccharide 4'-kinase activity
C1C92_14660	COG2835	tetraacyldisaccharide 4'-kinase activity
C1C92_14665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1C92_14670	COG2197	response regulator
C1C92_14675	COG0322	excinuclease ABC activity
C1C92_14710	COG0604	alcohol dehydrogenase
C1C92_14715	COG1309	transcriptional regulator
C1C92_14720	COG2261	transglycosylase associated protein
C1C92_14725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_14735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C92_14740	COG0215	cysteine-tRNA ligase activity
C1C92_14765	COG2199	diguanylate cyclase activity
C1C92_14765	COG2203	Gaf domain
C1C92_14800	COG2119	membrane
C1C92_14805	COG0023	Translation Initiation Factor
C1C92_14815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1C92_14840	COG4139	cobalamin transport
C1C92_14845	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1C92_14855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_14860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1C92_14865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C92_14870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1C92_14875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1C92_14885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1C92_14890	COG0505	Belongs to the CarA family
C1C92_14895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1C92_14900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C92_14905	COG3706	GGDEF domain
C1C92_14945	COG0513	Belongs to the DEAD box helicase family
C1C92_14955	COG4104	PAAR repeat-containing protein
C1C92_14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_14985	COG0765	amino acid transport
C1C92_14995	COG0493	'glutamate synthase
C1C92_15000	COG0070	glutamate synthase
C1C92_15000	COG0067	glutamate synthase
C1C92_15000	COG0069	glutamate synthase activity
C1C92_15005	COG1242	4 iron, 4 sulfur cluster binding
C1C92_15050	COG1113	amino acid transport
C1C92_15060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1C92_15065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1C92_15065	COG0574	Belongs to the PEP-utilizing enzyme family
C1C92_15070	COG1119	ATPase activity
C1C92_15090	COG1464	Belongs to the NlpA lipoprotein family
C1C92_15100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C92_15105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C92_15115	COG0101	tRNA pseudouridine synthase activity
C1C92_15120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1C92_15125	COG0285	dihydrofolate synthase activity
C1C92_15130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1C92_15135	COG2920	part of a sulfur-relay system
C1C92_15140	COG1289	transmembrane transporter activity
C1C92_15145	COG0670	Belongs to the BI1 family
C1C92_15185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1C92_15190	COG0840	transmembrane signaling receptor activity
C1C92_15195	COG5001	Diguanylate cyclase
C1C92_15200	COG0564	pseudouridine synthase activity
C1C92_15215	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1C92_15225	COG0625	glutathione transferase activity
C1C92_15240	COG0367	asparagine synthase
C1C92_15250	COG0647	UMP catabolic process
C1C92_15255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C92_15260	COG0604	alcohol dehydrogenase
C1C92_15265	COG1902	pentaerythritol trinitrate reductase activity
C1C92_15270	COG1253	flavin adenine dinucleotide binding
C1C92_15280	COG0277	FAD linked oxidase domain protein
C1C92_15280	COG0247	lactate metabolic process
C1C92_15290	COG2050	protein possibly involved in aromatic compounds catabolism
C1C92_15305	COG5001	Diguanylate cyclase
C1C92_15310	COG0583	DNA-binding transcription factor activity
C1C92_15315	COG2814	Major facilitator Superfamily
C1C92_15320	COG2056	Na+-H+ antiporter family
C1C92_15325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_15340	COG0483	inositol monophosphate 1-phosphatase activity
C1C92_15350	COG0625	glutathione transferase activity
C1C92_15355	COG0625	glutathione transferase activity
C1C92_15365	COG0601	transmembrane transport
C1C92_15370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_15375	COG0444	Belongs to the ABC transporter superfamily
C1C92_15380	COG2814	Major facilitator Superfamily
C1C92_15400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_15405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_15410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1C92_15415	COG0509	glycine decarboxylation via glycine cleavage system
C1C92_15420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C92_15420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C92_15445	COG3634	alkyl hydroperoxide reductase activity
C1C92_15450	COG0450	alkyl hydroperoxide reductase
C1C92_15455	COG0517	IMP dehydrogenase activity
C1C92_15460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1C92_15465	COG0343	queuine tRNA-ribosyltransferase activity
C1C92_15470	COG1862	Preprotein translocase
C1C92_15475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_15480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_15485	COG2897	thiosulfate sulfurtransferase activity
C1C92_15495	COG0826	peptidase U32
C1C92_15500	COG0826	peptidase U32
C1C92_15505	COG3154	lipid carrier protein
C1C92_15520	COG1104	cysteine desulfurase activity
C1C92_15525	COG0822	iron-sulfur transferase activity
C1C92_15535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C92_15540	COG0443	Heat shock 70 kDa protein
C1C92_15545	COG0633	Ferredoxin
C1C92_15555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_15560	COG0105	UTP biosynthetic process
C1C92_15565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1C92_15575	COG1426	Protein conserved in bacteria
C1C92_15585	COG0124	histidyl-tRNA synthetase
C1C92_15590	COG2976	Protein conserved in bacteria
C1C92_15595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_15600	COG1160	GTP binding
C1C92_15605	COG1645	bacterial-type flagellum-dependent swarming motility
C1C92_15610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C92_15615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1C92_15615	COG0047	phosphoribosylformylglycinamidine synthase activity
C1C92_15620	COG1007	ATP synthesis coupled electron transport
C1C92_15625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_15635	COG0713	ATP synthesis coupled electron transport
C1C92_15640	COG0839	Belongs to the complex I subunit 6 family
C1C92_15645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_15650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1C92_15655	COG1034	ATP synthesis coupled electron transport
C1C92_15670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_15670	COG0649	NAD binding
C1C92_15675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_15680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_15685	COG1360	Flagellar Motor Protein
C1C92_15690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_15705	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1C92_15715	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1C92_15725	COG0724	RNA recognition motif
C1C92_15730	COG4989	oxidoreductase activity
C1C92_15755	COG0745	RESPONSE REGULATOR receiver
C1C92_15760	COG0583	DNA-binding transcription factor activity
C1C92_15770	COG5001	Diguanylate cyclase
C1C92_15770	COG3300	MHYT domain
C1C92_15775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1C92_15805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C92_15810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1C92_15815	COG0539	negative regulation of cytoplasmic translation
C1C92_15820	COG0776	regulation of translation
C1C92_15830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1C92_15850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1C92_15855	COG0602	queuosine metabolic process
C1C92_15860	COG3530	Putative quorum-sensing-regulated virulence factor
C1C92_15865	COG2096	Adenosyltransferase
C1C92_15870	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_15875	COG1757	Na H antiporter
C1C92_15880	COG1435	thymidine kinase activity
C1C92_15915	COG1349	DNA-binding transcription factor activity
C1C92_15920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1C92_15940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1C92_15945	COG0626	cystathionine gamma-synthase activity
C1C92_15955	COG2910	NAD(P)H-binding
C1C92_15960	COG0583	DNA-binding transcription factor activity
C1C92_15965	COG1917	Cupin 2, conserved barrel domain protein
C1C92_15965	COG4977	sequence-specific DNA binding
C1C92_15970	COG2200	EAL domain
C1C92_15975	COG3706	GGDEF domain
C1C92_15980	COG4774	siderophore transport
C1C92_15990	COG0583	DNA-binding transcription factor activity
C1C92_15995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C92_16005	COG0617	tRNA 3'-terminal CCA addition
C1C92_16005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1C92_16005	COG0517	IMP dehydrogenase activity
C1C92_16010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_16015	COG3046	protein related to deoxyribodipyrimidine photolyase
C1C92_16030	COG4235	cytochrome complex assembly
C1C92_16030	COG3088	subunit of a heme lyase
C1C92_16035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_16040	COG1138	Cytochrome C-type biogenesis protein
C1C92_16045	COG3301	Polysulphide reductase, NrfD
C1C92_16050	COG0437	4 iron, 4 sulfur cluster binding
C1C92_16055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1C92_16070	COG0247	lactate metabolic process
C1C92_16075	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1C92_16080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1C92_16085	COG3012	SEC-C Motif Domain Protein
C1C92_16090	COG0840	transmembrane signaling receptor activity
C1C92_16095	COG1940	carbohydrate kinase activity
C1C92_16095	COG1846	Transcriptional regulator
C1C92_16100	COG3290	protein histidine kinase activity
C1C92_16105	COG4565	transcriptional regulatory protein
C1C92_16120	COG3181	Tripartite tricarboxylate transporter family receptor
C1C92_16125	COG0741	lytic transglycosylase activity
C1C92_16125	COG1196	nuclear chromosome segregation
C1C92_16125	COG0739	heme binding
C1C92_16130	COG2985	domain, Protein
C1C92_16130	COG0569	domain protein
C1C92_16145	COG0556	nucleotide-excision repair
C1C92_16155	COG0586	Pfam SNARE associated Golgi protein
C1C92_16160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1C92_16165	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C92_16170	COG2186	Transcriptional regulator
C1C92_16175	COG2719	SpoVR family
C1C92_16180	COG2718	Belongs to the UPF0229 family
C1C92_16185	COG2766	serine protein kinase
C1C92_16190	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_16195	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1C92_16200	COG0814	amino acid
C1C92_16230	COG0058	SHG alpha-glucan phosphorylase activity
C1C92_16240	COG0471	metal ion transport
C1C92_16245	COG3118	belongs to the thioredoxin family
C1C92_16255	COG1132	(ABC) transporter
C1C92_16260	COG1132	(ABC) transporter
C1C92_16280	COG2501	S4 domain
C1C92_16290	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1C92_16310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1C92_16315	COG2329	Antibiotic biosynthesis monooxygenase
C1C92_16350	COG0513	Belongs to the DEAD box helicase family
C1C92_16355	COG0386	Belongs to the glutathione peroxidase family
C1C92_16365	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1C92_16380	COG0730	response to heat
C1C92_16385	COG0583	DNA-binding transcription factor activity
C1C92_16400	COG3593	DNA synthesis involved in DNA repair
C1C92_16440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_16445	COG1011	Hydrolase
C1C92_16450	COG1473	amidohydrolase
C1C92_16455	COG0205	6-phosphofructokinase activity
C1C92_16465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1C92_16470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_16480	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1C92_16485	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1C92_16515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1C92_16520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_16535	COG0588	phosphoglycerate mutase activity
C1C92_16550	COG1280	lysine exporter protein (LysE YggA)
C1C92_16565	COG2824	Alkylphosphonate utilization operon protein PhnA
C1C92_16600	COG2840	Smr protein MutS2
C1C92_16605	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C92_16610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1C92_16620	COG0513	Belongs to the DEAD box helicase family
C1C92_16625	COG5654	RES domain protein
C1C92_16635	COG0814	amino acid
C1C92_16640	COG1609	Transcriptional regulator
C1C92_16645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_16645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_16650	COG1105	Belongs to the carbohydrate kinase PfkB family
C1C92_16655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C92_16655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C92_16655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1C92_16660	COG3313	Fe-S protein
C1C92_16665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1C92_16670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_16675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_16680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_16690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_16715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1C92_16720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1C92_16725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1C92_16730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1C92_16735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1C92_16740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_16740	COG0072	phenylalanine-tRNA ligase activity
C1C92_16745	COG0776	regulation of translation
C1C92_16775	COG3300	MHYT domain
C1C92_16775	COG5001	Diguanylate cyclase
C1C92_16780	COG1609	Transcriptional regulator
C1C92_16785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_16790	COG1879	ABC-type sugar transport system periplasmic component
C1C92_16795	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_16800	COG1129	ABC transporter
C1C92_16805	COG1869	D-ribose catabolic process
C1C92_16810	COG0625	glutathione transferase activity
C1C92_16825	COG0037	tRNA processing
C1C92_16830	COG0589	response to stress
C1C92_16835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C92_16850	COG2217	Heavy metal translocating P-type atpase
C1C92_16860	COG2010	Cytochrome c
C1C92_16875	COG3278	Belongs to the heme-copper respiratory oxidase family
C1C92_16885	COG1956	GAF domain-containing protein
C1C92_16890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1C92_16900	COG0308	aminopeptidase N
C1C92_16910	COG2902	Dehydrogenase
C1C92_16915	COG0167	dihydroorotate dehydrogenase activity
C1C92_16925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C92_16925	COG0116	Belongs to the methyltransferase superfamily
C1C92_16950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C92_16955	COG1067	ATP-dependent peptidase activity
C1C92_16965	COG3141	response to X-ray
C1C92_16975	COG2995	paraquat-inducible protein a
C1C92_16985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_16985	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1C92_17020	COG0084	hydrolase, TatD family'
C1C92_17025	COG0470	DNA polymerase III
C1C92_17030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1C92_17035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1C92_17040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1C92_17045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C92_17050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1C92_17055	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_17065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1C92_17070	COG0416	fatty acid biosynthetic process
C1C92_17075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1C92_17080	COG1399	metal-binding, possibly nucleic acid-binding protein
C1C92_17095	COG0564	pseudouridine synthase activity
C1C92_17100	COG1530	ribonuclease E activity
C1C92_17105	COG0306	phosphate transporter
C1C92_17110	COG0717	Belongs to the dCTP deaminase family
C1C92_17115	COG0572	uridine kinase
C1C92_17120	COG0489	protein tyrosine kinase activity
C1C92_17125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_17125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_17130	COG0625	glutathione transferase activity
C1C92_17135	COG1254	Belongs to the acylphosphatase family
C1C92_17140	COG0840	transmembrane signaling receptor activity
C1C92_17145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C92_17160	COG0709	Synthesizes selenophosphate from selenide and ATP
C1C92_17165	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1C92_17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C92_17175	COG3437	response regulator, receiver
C1C92_17195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1C92_17205	COG1643	Atp-dependent helicase
C1C92_17210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1C92_17210	COG0517	IMP dehydrogenase activity
C1C92_17210	COG0617	tRNA 3'-terminal CCA addition
C1C92_17215	COG2197	response regulator
C1C92_17235	COG0583	DNA-binding transcription factor activity
C1C92_17240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1C92_17250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1C92_17255	COG2832	Protein of unknown function (DUF454)
C1C92_17260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C92_17270	COG0697	spore germination
C1C92_17285	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_17290	COG0596	Alpha beta hydrolase
C1C92_17300	COG1214	PFAM Peptidase M22, glycoprotease
C1C92_17305	COG1199	ATP-dependent helicase activity
C1C92_17315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1C92_17320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1C92_17325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1C92_17330	COG0131	Imidazoleglycerol-phosphate dehydratase
C1C92_17330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C92_17335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1C92_17340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1C92_17345	COG3437	response regulator, receiver
C1C92_17355	COG0784	Response regulator, receiver
C1C92_17355	COG2198	Histidine kinase
C1C92_17355	COG2205	protein histidine kinase activity
C1C92_17360	COG0107	imidazoleglycerol-phosphate synthase activity
C1C92_17365	COG0140	phosphoribosyl-ATP diphosphatase activity
C1C92_17365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1C92_17375	COG2378	regulation of single-species biofilm formation
C1C92_17380	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_17385	COG3134	Outer membrane lipoprotein
C1C92_17400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_17425	COG4681	YaeQ
C1C92_17435	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1C92_17435	COG1024	Enoyl-CoA hydratase
C1C92_17440	COG0183	Belongs to the thiolase family
C1C92_17445	COG0714	Associated with various cellular activities
C1C92_17485	COG2067	long-chain fatty acid transport protein
C1C92_17490	COG2067	long-chain fatty acid transport protein
C1C92_17495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1C92_17510	COG1301	dicarboxylic acid transport
C1C92_17515	COG3123	guanosine phosphorylase activity
C1C92_17520	COG1760	l-serine dehydratase
C1C92_17530	COG1760	l-serine dehydratase
C1C92_17535	COG2951	lytic endotransglycosylase activity
C1C92_17540	COG3100	YcgL domain-containing protein
C1C92_17545	COG0850	regulation of cytokinetic process
C1C92_17550	COG2894	cell division
C1C92_17555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1C92_17560	COG3099	Belongs to the UPF0263 family
C1C92_17565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C92_17585	COG2996	Protein conserved in bacteria
C1C92_17610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1C92_17615	COG0697	spore germination
C1C92_17620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1C92_17625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_17640	COG0307	riboflavin synthase, alpha
C1C92_17650	COG0534	Mate efflux family protein
C1C92_17680	COG0417	DNA replication proofreading
C1C92_17695	COG1560	Kdo2-lipid A biosynthetic process
C1C92_17700	COG1560	Kdo2-lipid A biosynthetic process
C1C92_17710	COG0583	DNA-binding transcription factor activity
C1C92_17715	COG0673	inositol 2-dehydrogenase activity
C1C92_17720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1C92_17740	COG0583	DNA-binding transcription factor activity
C1C92_17750	COG2723	6-phospho-beta-galactosidase activity
C1C92_17755	COG0583	DNA-binding transcription factor activity
C1C92_17765	COG0243	molybdopterin cofactor binding
C1C92_17770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1C92_17785	COG0583	DNA-binding transcription factor activity
C1C92_17790	COG1879	ABC-type sugar transport system periplasmic component
C1C92_17795	COG1129	ABC transporter
C1C92_17800	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_17805	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_17820	COG0702	epimerase
C1C92_17825	COG1073	alpha beta
C1C92_17830	COG1073	alpha beta
C1C92_17870	COG0730	response to heat
C1C92_17880	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_17890	COG1024	Enoyl-CoA hydratase
C1C92_17895	COG1024	Enoyl-CoA hydratase
C1C92_17900	COG1960	acyl-CoA dehydrogenase activity
C1C92_17910	COG1960	acyl-CoA dehydrogenase activity
C1C92_17915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1C92_17920	COG1024	Enoyl-CoA hydratase
C1C92_17945	COG1584	GPR1 FUN34 yaaH family protein
C1C92_17950	COG3228	Belongs to the MtfA family
C1C92_17960	COG1115	amino acid carrier protein
C1C92_17965	COG1024	Enoyl-CoA hydratase
C1C92_17980	COG3162	membrane
C1C92_17985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C92_17990	COG0488	(ABC) transporter
C1C92_17995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C92_18000	COG0776	regulation of translation
C1C92_18005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1C92_18010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1C92_18015	COG0740	serine-type endopeptidase activity
C1C92_18020	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1C92_18035	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1C92_18040	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C92_18045	COG1136	(ABC) transporter
C1C92_18050	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C92_18060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1C92_18065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1C92_18085	COG2062	phosphohistidine phosphatase, SixA
C1C92_18095	COG0500	methyltransferase
C1C92_18105	COG1846	Transcriptional regulator
C1C92_18180	COG0789	Transcriptional regulator
C1C92_18265	COG0582	viral genome integration into host DNA
C1C92_18275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C92_18275	COG0519	Catalyzes the synthesis of GMP from XMP
C1C92_18280	COG0516	GMP reductase activity
C1C92_18280	COG0517	IMP dehydrogenase activity
C1C92_18290	COG1874	Beta-galactosidase
C1C92_18290	COG0366	Alpha amylase catalytic
C1C92_18300	COG1570	exodeoxyribonuclease VII activity
C1C92_18310	COG2885	chlorophyll binding
C1C92_18330	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1C92_18340	COG3768	UPF0283 membrane protein
C1C92_18345	COG3106	COG3106 Predicted ATPase
C1C92_18360	COG1842	Phage shock protein A
C1C92_18365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1C92_18380	COG4171	peptide transport system, permease
C1C92_18390	COG4172	Belongs to the ABC transporter superfamily
C1C92_18400	COG1609	Transcriptional regulator
C1C92_18405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_18405	COG1263	PTS System
C1C92_18410	COG2723	6-phospho-beta-galactosidase activity
C1C92_18415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1C92_18420	COG1286	toxin biosynthetic process
C1C92_18425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1C92_18435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1C92_18440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1C92_18445	COG0531	amino acid
C1C92_18445	COG1674	ftsk spoiiie
C1C92_18455	COG0686	Belongs to the AlaDH PNT family
C1C92_18460	COG0492	ferredoxin-NADP+ reductase activity
C1C92_18465	COG3706	GGDEF domain
C1C92_18470	COG3134	Outer membrane lipoprotein
C1C92_18475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1C92_18480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1C92_18485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1C92_18490	COG0542	response to heat
C1C92_18495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1C92_18500	COG1278	Cold shock
C1C92_18505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C92_18520	COG1944	ATP diphosphatase activity
C1C92_18525	COG2116	formate transmembrane transporter activity
C1C92_18530	COG1882	Formate acetyltransferase
C1C92_18535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_18545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1C92_18555	COG1840	ABC-type Fe3 transport system, periplasmic component
C1C92_18560	COG3842	ATPase activity
C1C92_18570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_18575	COG2983	Belongs to the UPF0260 family
C1C92_18585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1C92_18590	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C92_18595	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C92_18600	COG0567	Dehydrogenase, E1 component
C1C92_18615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1C92_18620	COG2009	succinate dehydrogenase
C1C92_18640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C92_18645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_18645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1C92_18655	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C92_18670	COG1451	nucleotide metabolic process
C1C92_18685	COG0254	rRNA binding
C1C92_18690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C92_18700	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_18705	COG1129	ABC transporter
C1C92_18710	COG1879	ABC-type sugar transport system periplasmic component
C1C92_18715	COG1069	ribulokinase activity
C1C92_18725	COG2160	L-arabinose isomerase activity
C1C92_18730	COG0583	DNA-binding transcription factor activity
C1C92_18735	COG0436	Aminotransferase
C1C92_18740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_18755	COG0392	lysyltransferase activity
C1C92_18755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1C92_18790	COG1263	PTS System
C1C92_18790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_18795	COG1874	Beta-galactosidase
C1C92_18800	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C1C92_18805	COG3833	ABC-type maltose transport systems, permease component
C1C92_18810	COG1175	transmembrane transport
C1C92_18815	COG2182	Extracellular solute-binding protein
C1C92_18840	COG4580	involved in the transport of maltose and maltodextrins
C1C92_18850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_18855	COG1085	galactose-1-phosphate uridylyltransferase
C1C92_18860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1C92_18880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_18915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1C92_18935	COG2925	Exonuclease
C1C92_18945	COG3345	alpha-galactosidase
C1C92_18950	COG1380	Effector of murein hydrolase LrgA
C1C92_18955	COG1346	cytolysis
C1C92_18960	COG0295	cytidine deaminase activity
C1C92_18965	COG1022	Amp-dependent synthetase and ligase
C1C92_18980	COG0861	Integral membrane protein TerC family
C1C92_18985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_18990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1C92_18995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1C92_19035	COG4771	TonB-dependent receptor
C1C92_19040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_19045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_19050	COG1120	ATPase activity
C1C92_19065	COG3321	synthase
C1C92_19065	COG0300	oxidoreductase activity
C1C92_19065	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_19065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C92_19065	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_19075	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_19080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C92_19085	COG3433	isochorismatase activity
C1C92_19085	COG1535	isochorismatase
C1C92_19090	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1C92_19115	COG3300	MHYT domain
C1C92_19115	COG5001	Diguanylate cyclase
C1C92_19130	COG0840	transmembrane signaling receptor activity
C1C92_19135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_19140	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C1C92_19145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1C92_19150	COG0563	adenylate kinase activity
C1C92_19155	COG0326	Molecular chaperone. Has ATPase activity
C1C92_19165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1C92_19170	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1C92_19175	COG0298	carbon dioxide binding
C1C92_19185	COG0309	Hydrogenase expression formation protein (HypE)
C1C92_19190	COG0375	protein maturation
C1C92_19195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1C92_19200	COG1124	(ABC) transporter
C1C92_19210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_19225	COG1773	rubredoxin
C1C92_19230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1C92_19235	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1C92_19240	COG5557	Pfam Polysulphide reductase, NrfD
C1C92_19245	COG0437	4 iron, 4 sulfur cluster binding
C1C92_19250	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1C92_19255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_19265	COG0659	secondary active sulfate transmembrane transporter activity
C1C92_19285	COG2308	Evidence 4 Homologs of previously reported genes of
C1C92_19320	COG0672	)-iron permease
C1C92_19345	COG2814	Major facilitator Superfamily
C1C92_19365	COG1136	(ABC) transporter
C1C92_19395	COG1139	Iron-sulfur cluster binding protein
C1C92_19400	COG0247	lactate metabolic process
C1C92_19405	COG1620	l-lactate permease
C1C92_19410	COG0583	DNA-binding transcription factor activity
C1C92_19435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1C92_19440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C92_19440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1C92_19445	COG0527	aspartate kinase activity
C1C92_19455	COG1368	sulfuric ester hydrolase activity
C1C92_19460	COG0393	Putative heavy-metal-binding
C1C92_19470	COG1252	NADH dehydrogenase
C1C92_19475	COG3150	esterase
C1C92_19480	COG1164	Oligoendopeptidase f
C1C92_19485	COG1164	Oligoendopeptidase f
C1C92_19505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_19510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_19545	COG0537	adenosine 5'-monophosphoramidase activity
C1C92_19560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1C92_19580	COG1301	dicarboxylic acid transport
C1C92_19590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_19595	COG0861	Integral membrane protein TerC family
C1C92_19605	COG0444	Belongs to the ABC transporter superfamily
C1C92_19610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_19615	COG0601	transmembrane transport
C1C92_19625	COG2095	MarC family integral membrane protein
C1C92_19630	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_19630	COG1454	alcohol dehydrogenase
C1C92_19645	COG3279	Response regulator of the LytR AlgR family
C1C92_19650	COG1966	Carbon starvation protein
C1C92_19655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1C92_19655	COG3264	Mechanosensitive ion channel
C1C92_19665	COG1566	PFAM secretion protein HlyD family protein
C1C92_19670	COG1061	Type III restriction enzyme res subunit
C1C92_19680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1C92_19690	COG0436	Aminotransferase
C1C92_19695	COG1288	antiporter activity
C1C92_19700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C92_19715	COG0697	spore germination
C1C92_19720	COG4657	Part of a membrane complex involved in electron transport
C1C92_19725	COG2878	Part of a membrane complex involved in electron transport
C1C92_19735	COG4658	electron transport chain
C1C92_19740	COG4659	FMN binding
C1C92_19745	COG4660	Part of a membrane complex involved in electron transport
C1C92_19750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1C92_19755	COG0346	lactoylglutathione lyase activity
C1C92_19775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1C92_19785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C92_19790	COG1086	Polysaccharide biosynthesis protein
C1C92_19795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1C92_19805	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C1C92_19810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1C92_19825	COG2089	acid synthase
C1C92_19865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1C92_19885	COG0301	tRNA thio-modification
C1C92_19885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_19895	COG4953	penicillin-binding protein 1C
C1C92_19900	COG2373	Large extracellular alpha-helical protein
C1C92_19915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C92_19925	COG4160	amino acid transport
C1C92_19935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_19945	COG2431	L-lysine efflux transmembrane transporter activity
C1C92_19950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C92_19955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_19980	COG1393	Belongs to the ArsC family
C1C92_19990	COG4783	chaperone-mediated protein folding
C1C92_19995	COG0425	Belongs to the sulfur carrier protein TusA family
C1C92_20010	COG0596	Alpha beta hydrolase
C1C92_20020	COG3842	ATPase activity
C1C92_20025	COG3833	ABC-type maltose transport systems, permease component
C1C92_20030	COG1175	transmembrane transport
C1C92_20040	COG3081	Nucleoid-associated protein
C1C92_20045	COG3082	Protein of unknown function (DUF1414)
C1C92_20050	COG3083	sulfuric ester hydrolase activity
C1C92_20055	COG4771	TonB-dependent receptor
C1C92_20060	COG1770	oligopeptidase
C1C92_20080	COG4574	serine-type endopeptidase inhibitor activity
C1C92_20085	COG3085	chromosome segregation
C1C92_20095	COG0287	Prephenate dehydrogenase
C1C92_20095	COG1605	Chorismate mutase
C1C92_20100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_20105	COG0584	glycerophosphoryl diester phosphodiesterase
C1C92_20115	COG1349	DNA-binding transcription factor activity
C1C92_20120	COG2271	Major facilitator Superfamily
C1C92_20125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1C92_20130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1C92_20135	COG0583	DNA-binding transcription factor activity
C1C92_20155	COG0656	L-ascorbic acid biosynthetic process
C1C92_20160	COG2814	Major facilitator Superfamily
C1C92_20180	COG1294	oxidase, subunit
C1C92_20190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_20200	COG2979	Protein of unknown function (DUF533)
C1C92_20220	COG0583	DNA-binding transcription factor activity
C1C92_20230	COG2807	transmembrane transport
C1C92_20235	COG1187	pseudouridine synthase activity
C1C92_20240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1C92_20260	COG1061	Type III restriction enzyme res subunit
C1C92_20285	COG1166	arginine decarboxylase activity
C1C92_20300	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C92_20315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1C92_20330	COG0583	DNA-binding transcription factor activity
C1C92_20340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1C92_20345	COG0840	transmembrane signaling receptor activity
C1C92_20350	COG0302	gtp cyclohydrolase
C1C92_20360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C92_20375	COG2267	carboxylic ester hydrolase activity
C1C92_20380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1C92_20395	COG0314	molybdopterin synthase activity
C1C92_20400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1C92_20405	COG0315	cyclic pyranopterin monophosphate synthase activity
C1C92_20410	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C92_20415	COG3005	denitrification pathway
C1C92_20425	COG0348	domain, Protein
C1C92_20430	COG0437	4 iron, 4 sulfur cluster binding
C1C92_20435	COG0243	molybdopterin cofactor binding
C1C92_20445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_20445	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_20450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1C92_20455	COG3850	Histidine kinase
C1C92_20460	COG2197	response regulator
C1C92_20485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1C92_20495	COG0121	glutamine amidotransferase
C1C92_20500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C92_20505	COG1960	acyl-CoA dehydrogenase activity
C1C92_20510	COG3437	response regulator, receiver
C1C92_20510	COG0784	Response regulator, receiver
C1C92_20520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_20525	COG0328	RNA-DNA hybrid ribonuclease activity
C1C92_20530	COG2226	methyltransferase
C1C92_20535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C92_20540	COG0741	lytic transglycosylase activity
C1C92_20540	COG1388	LysM domain
C1C92_20555	COG1607	acyl-coa hydrolase
C1C92_20570	COG0741	lytic transglycosylase activity
C1C92_20580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1C92_20605	COG2911	Protein conserved in bacteria
C1C92_20610	COG0729	surface antigen
C1C92_20620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C92_20630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C92_20640	COG4134	Bacterial extracellular solute-binding protein
C1C92_20655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1C92_20660	COG2951	lytic endotransglycosylase activity
C1C92_20665	COG1846	Transcriptional regulator
C1C92_20675	COG0033	Phosphoglucomutase
C1C92_20680	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1C92_20700	COG0716	FMN binding
C1C92_20710	COG0735	belongs to the Fur family
C1C92_20715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_20725	COG2190	(PTS) system
C1C92_20725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_20725	COG1263	PTS System
C1C92_20730	COG0363	glucosamine-6-phosphate deaminase activity
C1C92_20735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C92_20740	COG1846	Transcriptional regulator
C1C92_20740	COG1940	carbohydrate kinase activity
C1C92_20745	COG2194	sulfuric ester hydrolase activity
C1C92_20750	COG0217	transcriptional regulatory protein
C1C92_20755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1C92_20765	COG1801	Protein of unknown function DUF72
C1C92_20770	COG4106	trans-aconitate 2-methyltransferase activity
C1C92_20775	COG0500	methyltransferase
C1C92_20795	COG0583	DNA-binding transcription factor activity
C1C92_20800	COG0791	NLP P60 protein
C1C92_20815	COG1309	transcriptional regulator
C1C92_20825	COG1454	alcohol dehydrogenase
C1C92_20850	COG0534	Mate efflux family protein
C1C92_20860	COG2841	Protein conserved in bacteria
C1C92_20870	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1C92_20870	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1C92_20870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1C92_20870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1C92_20880	COG0633	Ferredoxin
C1C92_20880	COG3217	Mosc domain protein beta barrel domain protein
C1C92_20880	COG0633	Ferredoxin
C1C92_20880	COG3217	Mosc domain protein beta barrel domain protein
C1C92_20885	COG0501	Belongs to the peptidase M48B family
C1C92_20890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1C92_20895	COG1073	alpha beta
C1C92_20895	COG2226	methyltransferase
C1C92_20900	COG0156	8-amino-7-oxononanoate synthase activity
C1C92_20905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1C92_20925	COG0017	Asparaginyl-tRNA synthetase
C1C92_20930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C92_20945	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C92_20955	COG1393	Belongs to the ArsC family
C1C92_20960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1C92_20965	COG1876	peptidase activity
C1C92_20975	COG3263	regulation of cellular component size
C1C92_20985	COG1280	lysine exporter protein (LysE YggA)
C1C92_21015	COG1957	nucleoside hydrolase
C1C92_21020	COG0564	pseudouridine synthase activity
C1C92_21030	COG1454	alcohol dehydrogenase
C1C92_21035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_21040	COG0702	epimerase
C1C92_21050	COG2867	negative regulation of translational initiation
C1C92_21055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1C92_21300	COG0305	Participates in initiation and elongation during chromosome replication
C1C92_21365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_21395	COG2974	May be involved in recombination
C1C92_21435	COG0582	viral genome integration into host DNA
C1C92_21440	COG0582	viral genome integration into host DNA
C1C92_21445	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_21495	COG1596	polysaccharide export
C1C92_21555	COG3039	Transposase
C1C92_21565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_21605	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_21615	COG4983	Phage plasmid primase, P4 family domain protein
C1C92_21635	COG5377	YqaJ viral recombinase family
C1C92_21670	COG2003	Belongs to the UPF0758 family
C1C92_21735	COG1715	Restriction endonuclease
C1C92_21745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_21755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1C92_21760	COG0210	DNA helicase
C1C92_21795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_21805	COG0800	Aldolase
C1C92_21820	COG3153	acetyltransferase
C1C92_21850	COG0259	pyridoxamine-phosphate oxidase activity
C1C92_21865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_21865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_21870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1C92_21895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_21900	COG1138	Cytochrome C-type biogenesis protein
C1C92_21905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1C92_21910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_21915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_21920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_21935	COG0835	chemotaxis
C1C92_21945	COG1192	Involved in chromosome partitioning
C1C92_21950	COG1360	Flagellar Motor Protein
C1C92_21955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_21960	COG2201	protein-glutamate methylesterase activity
C1C92_21965	COG0643	Histidine kinase
C1C92_21965	COG0784	Response regulator, receiver
C1C92_21965	COG2198	Histidine kinase
C1C92_21970	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1C92_21995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1C92_22005	COG1684	flagellar biosynthetic protein fliR
C1C92_22075	COG1677	Flagellar hook-basal body complex protein FliE
C1C92_22165	COG0732	type I restriction modification DNA specificity domain
C1C92_22190	COG3074	FtsZ-dependent cytokinesis
C1C92_22220	COG3118	belongs to the thioredoxin family
C1C92_22220	COG0457	Tetratricopeptide repeat
C1C92_22230	COG1846	Transcriptional regulator
C1C92_22520	COG3093	addiction module antidote protein HigA
C1C92_22530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs