locus-tag	class	description
C1C91_00020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_00025	COG2095	MarC family integral membrane protein
C1C91_00030	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_00030	COG1454	alcohol dehydrogenase
C1C91_00040	COG3275	phosphorelay sensor kinase activity
C1C91_00045	COG3279	Response regulator of the LytR AlgR family
C1C91_00050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_00070	COG1966	Carbon starvation protein
C1C91_00080	COG0675	Transposase, IS605 OrfB family
C1C91_00100	COG1566	PFAM secretion protein HlyD family protein
C1C91_00105	COG1061	Type III restriction enzyme res subunit
C1C91_00115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1C91_00125	COG0436	Aminotransferase
C1C91_00130	COG1288	antiporter activity
C1C91_00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C91_00180	COG3039	Transposase
C1C91_00185	COG5433	transposase activity
C1C91_00190	COG0675	Transposase, IS605 OrfB family
C1C91_00195	COG4657	Part of a membrane complex involved in electron transport
C1C91_00200	COG2878	Part of a membrane complex involved in electron transport
C1C91_00210	COG4658	electron transport chain
C1C91_00215	COG4659	FMN binding
C1C91_00225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1C91_00230	COG0346	lactoylglutathione lyase activity
C1C91_00240	COG0675	Transposase, IS605 OrfB family
C1C91_00270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1C91_00280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C91_00290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1C91_00295	COG1213	nucleotidyl transferase
C1C91_00300	COG0512	Glutamine amidotransferase of anthranilate synthase
C1C91_00300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C91_00305	COG3848	Pyruvate phosphate dikinase
C1C91_00305	COG0574	Belongs to the PEP-utilizing enzyme family
C1C91_00315	COG0529	Catalyzes the synthesis of activated sulfate
C1C91_00320	COG0297	glycogen (starch) synthase activity
C1C91_00325	COG0438	transferase activity, transferring glycosyl groups
C1C91_00350	COG0438	transferase activity, transferring glycosyl groups
C1C91_00365	COG1216	Glycosyl transferase, family 2
C1C91_00380	COG0318	PFAM AMP-dependent synthetase and ligase
C1C91_00385	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_00400	COG1083	cytidylyl-transferase
C1C91_00410	COG2089	acid synthase
C1C91_00425	COG4310	Domain of unknown function (DUF2172)
C1C91_00475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1C91_00495	COG0301	tRNA thio-modification
C1C91_00495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C91_00505	COG4953	penicillin-binding protein 1C
C1C91_00510	COG2373	Large extracellular alpha-helical protein
C1C91_00515	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C91_00525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C91_00535	COG4160	amino acid transport
C1C91_00540	COG4215	(ABC) transporter
C1C91_00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_00560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C91_00590	COG1393	Belongs to the ArsC family
C1C91_00600	COG4783	chaperone-mediated protein folding
C1C91_00615	COG0596	Alpha beta hydrolase
C1C91_00625	COG3842	ATPase activity
C1C91_00635	COG1175	transmembrane transport
C1C91_00645	COG3081	Nucleoid-associated protein
C1C91_00650	COG3082	Protein of unknown function (DUF1414)
C1C91_00655	COG3083	sulfuric ester hydrolase activity
C1C91_00660	COG4771	TonB-dependent receptor
C1C91_00665	COG1770	oligopeptidase
C1C91_00685	COG4574	serine-type endopeptidase inhibitor activity
C1C91_00690	COG3085	chromosome segregation
C1C91_00705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C91_00710	COG0584	glycerophosphoryl diester phosphodiesterase
C1C91_00725	COG1349	DNA-binding transcription factor activity
C1C91_00730	COG2271	Major facilitator Superfamily
C1C91_00735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1C91_00740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1C91_00745	COG0583	DNA-binding transcription factor activity
C1C91_00765	COG0656	L-ascorbic acid biosynthetic process
C1C91_00770	COG2814	Major facilitator Superfamily
C1C91_00780	COG1294	oxidase, subunit
C1C91_00785	COG1271	oxidase subunit
C1C91_00800	COG2979	Protein of unknown function (DUF533)
C1C91_00820	COG0583	DNA-binding transcription factor activity
C1C91_00840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1C91_00850	COG0675	Transposase, IS605 OrfB family
C1C91_00895	COG1166	arginine decarboxylase activity
C1C91_00910	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C91_00940	COG0583	DNA-binding transcription factor activity
C1C91_00950	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1C91_00955	COG0840	transmembrane signaling receptor activity
C1C91_00960	COG0302	gtp cyclohydrolase
C1C91_00970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C91_00975	COG2267	carboxylic ester hydrolase activity
C1C91_00980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1C91_00995	COG0314	molybdopterin synthase activity
C1C91_01000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1C91_01005	COG0315	cyclic pyranopterin monophosphate synthase activity
C1C91_01010	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C91_01015	COG3005	denitrification pathway
C1C91_01025	COG0348	domain, Protein
C1C91_01030	COG0437	4 iron, 4 sulfur cluster binding
C1C91_01035	COG0243	molybdopterin cofactor binding
C1C91_01045	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C91_01045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C91_01050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1C91_01060	COG2197	response regulator
C1C91_01075	COG0784	Response regulator, receiver
C1C91_01075	COG2205	protein histidine kinase activity
C1C91_01085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1C91_01095	COG0121	glutamine amidotransferase
C1C91_01100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C91_01105	COG1960	acyl-CoA dehydrogenase activity
C1C91_01110	COG0784	Response regulator, receiver
C1C91_01110	COG3437	response regulator, receiver
C1C91_01120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C91_01125	COG4974	Belongs to the 'phage' integrase family
C1C91_01130	COG0210	DNA helicase
C1C91_01140	COG4584	PFAM Integrase catalytic
C1C91_01145	COG1484	DNA-dependent DNA replication
C1C91_01180	COG2850	peptidyl-arginine hydroxylation
C1C91_01200	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C91_01240	COG0328	RNA-DNA hybrid ribonuclease activity
C1C91_01245	COG2226	methyltransferase
C1C91_01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C91_01255	COG1388	LysM domain
C1C91_01255	COG0741	lytic transglycosylase activity
C1C91_01260	COG3021	interspecies interaction between organisms
C1C91_01270	COG1607	acyl-coa hydrolase
C1C91_01285	COG0741	lytic transglycosylase activity
C1C91_01295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1C91_01310	COG2911	Protein conserved in bacteria
C1C91_01325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C91_01335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C91_01345	COG4134	Bacterial extracellular solute-binding protein
C1C91_01360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1C91_01365	COG2951	lytic endotransglycosylase activity
C1C91_01370	COG1846	Transcriptional regulator
C1C91_01380	COG0033	Phosphoglucomutase
C1C91_01385	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1C91_01390	COG0596	Alpha beta hydrolase
C1C91_01405	COG0716	FMN binding
C1C91_01415	COG0735	belongs to the Fur family
C1C91_01420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_01430	COG2190	(PTS) system
C1C91_01430	COG1263	PTS System
C1C91_01435	COG0363	glucosamine-6-phosphate deaminase activity
C1C91_01440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C91_01445	COG1940	carbohydrate kinase activity
C1C91_01445	COG1846	Transcriptional regulator
C1C91_01450	COG2194	sulfuric ester hydrolase activity
C1C91_01460	COG0217	transcriptional regulatory protein
C1C91_01465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1C91_01475	COG1801	Protein of unknown function DUF72
C1C91_01480	COG4106	trans-aconitate 2-methyltransferase activity
C1C91_01485	COG0500	methyltransferase
C1C91_01505	COG0583	DNA-binding transcription factor activity
C1C91_01510	COG0791	NLP P60 protein
C1C91_01525	COG1309	transcriptional regulator
C1C91_01535	COG1454	alcohol dehydrogenase
C1C91_01560	COG0534	Mate efflux family protein
C1C91_01570	COG2841	Protein conserved in bacteria
C1C91_01575	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1C91_01575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1C91_01575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1C91_01575	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1C91_01590	COG0501	Belongs to the peptidase M48B family
C1C91_01600	COG2226	methyltransferase
C1C91_01600	COG1073	alpha beta
C1C91_01605	COG0156	8-amino-7-oxononanoate synthase activity
C1C91_01610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1C91_01630	COG0017	Asparaginyl-tRNA synthetase
C1C91_01635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C91_01645	COG1473	amidohydrolase
C1C91_01650	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C91_01660	COG1393	Belongs to the ArsC family
C1C91_01665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1C91_01670	COG1876	peptidase activity
C1C91_01680	COG3263	regulation of cellular component size
C1C91_01690	COG1280	lysine exporter protein (LysE YggA)
C1C91_01715	COG1957	nucleoside hydrolase
C1C91_01725	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1C91_01730	COG1454	alcohol dehydrogenase
C1C91_01735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C91_01740	COG0702	epimerase
C1C91_01750	COG2867	negative regulation of translational initiation
C1C91_01755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1C91_01765	COG0582	viral genome integration into host DNA
C1C91_01825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C91_01850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1C91_01875	COG5499	transcription regulator containing HTH domain
C1C91_01890	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C91_01900	COG3311	Transcriptional regulator
C1C91_01915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C91_01920	COG0800	Aldolase
C1C91_01935	COG3153	acetyltransferase
C1C91_01965	COG0259	pyridoxamine-phosphate oxidase activity
C1C91_01980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C91_01980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C91_01985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1C91_02005	COG0457	Tetratricopeptide repeat
C1C91_02015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C91_02020	COG1138	Cytochrome C-type biogenesis protein
C1C91_02025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1C91_02030	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C91_02035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C91_02040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C91_02055	COG0835	chemotaxis
C1C91_02065	COG1192	Involved in chromosome partitioning
C1C91_02070	COG1360	Flagellar Motor Protein
C1C91_02075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C91_02080	COG2201	protein-glutamate methylesterase activity
C1C91_02085	COG0643	Histidine kinase
C1C91_02085	COG2198	Histidine kinase
C1C91_02090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1C91_02105	COG0455	bacterial-type flagellum organization
C1C91_02115	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1C91_02125	COG1684	flagellar biosynthetic protein fliR
C1C91_02130	COG1987	bacterial-type flagellum assembly
C1C91_02180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1C91_02190	COG1677	Flagellar hook-basal body complex protein FliE
C1C91_02200	COG1393	Belongs to the ArsC family
C1C91_02205	COG0798	PFAM Bile acid sodium symporter
C1C91_02220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1C91_02235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C91_02245	COG4608	Belongs to the ABC transporter superfamily
C1C91_02255	COG2971	BadF BadG BcrA BcrD
C1C91_02265	COG0840	transmembrane signaling receptor activity
C1C91_02275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1C91_02280	COG3724	N-succinylarginine dihydrolase activity
C1C91_02285	COG0616	signal peptide processing
C1C91_02290	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_02295	COG0583	DNA-binding transcription factor activity
C1C91_02305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1C91_02315	COG0583	DNA-binding transcription factor activity
C1C91_02325	COG1881	PFAM PEBP family protein
C1C91_02335	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1C91_02335	COG3408	Glycogen debranching enzyme
C1C91_02340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C91_02345	COG0739	heme binding
C1C91_02365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1C91_02375	COG3091	SprT-like family
C1C91_02385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1C91_02390	COG0189	ligase activity
C1C91_02395	COG1678	Uncharacterized ACR, COG1678
C1C91_02400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1C91_02430	COG1115	amino acid carrier protein
C1C91_02435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1C91_02450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1C91_02460	COG1301	dicarboxylic acid transport
C1C91_02465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1C91_02470	COG2912	Transglutaminase-like superfamily
C1C91_02480	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C91_02485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1C91_02490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1C91_02495	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1C91_02500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1C91_02510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1C91_02515	COG0193	aminoacyl-tRNA hydrolase activity
C1C91_02520	COG0012	GTP binding
C1C91_02565	COG0471	metal ion transport
C1C91_02565	COG0490	domain, Protein
C1C91_02590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C91_02605	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_02615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1C91_02630	COG0180	Tryptophanyl-tRNA synthetase
C1C91_02635	COG0546	phosphoglycolate phosphatase activity
C1C91_02640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1C91_02645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1C91_02655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1C91_02660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1C91_02690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1C91_02695	COG0583	DNA-binding transcription factor activity
C1C91_02710	COG0583	DNA-binding transcription factor activity
C1C91_02735	COG3264	Mechanosensitive ion channel
C1C91_02735	COG1511	domain protein
C1C91_02740	COG0584	glycerophosphoryl diester phosphodiesterase
C1C91_02750	COG1053	succinate dehydrogenase
C1C91_02755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1C91_02760	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C91_02765	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C91_02780	COG3214	Protein conserved in bacteria
C1C91_02785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C91_02805	COG0300	oxidoreductase activity
C1C91_02815	COG0745	RESPONSE REGULATOR receiver
C1C91_02825	COG4067	protein conserved in archaea
C1C91_02825	COG0189	ligase activity
C1C91_02830	COG0516	GMP reductase activity
C1C91_02840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1C91_02845	COG2011	ABC-type metal ion transport system permease component
C1C91_02850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1C91_02855	COG1464	Belongs to the NlpA lipoprotein family
C1C91_02870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C91_02895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C91_02925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C91_02930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1C91_02935	COG1702	phosphate starvation-inducible protein PhoH
C1C91_02940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1C91_02945	COG4535	Mg2 and Co2 transporter CorC
C1C91_02950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1C91_02955	COG2888	peptidyl-tyrosine sulfation
C1C91_02960	COG0495	leucyl-tRNA aminoacylation
C1C91_02975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1C91_02980	COG0799	negative regulation of ribosome biogenesis
C1C91_02985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1C91_02990	COG0768	penicillin binding
C1C91_02995	COG0772	Belongs to the SEDS family
C1C91_03000	COG2951	lytic endotransglycosylase activity
C1C91_03005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1C91_03010	COG1686	Belongs to the peptidase S11 family
C1C91_03015	COG2921	Belongs to the UPF0250 family
C1C91_03020	COG0321	lipoyl(octanoyl) transferase activity
C1C91_03030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1C91_03040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C91_03055	COG0789	Transcriptional regulator
C1C91_03080	COG1970	mechanosensitive ion channel activity
C1C91_03085	COG4974	Belongs to the 'phage' integrase family
C1C91_03090	COG0716	FMN binding
C1C91_03095	COG0312	modulator of DNA gyrase
C1C91_03105	COG0312	modulator of DNA gyrase
C1C91_03125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C91_03140	COG1422	Protein of unknown function (DUF1090)
C1C91_03145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C91_03150	COG2211	Major facilitator Superfamily
C1C91_03155	COG1185	polyribonucleotide nucleotidyltransferase activity
C1C91_03160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1C91_03165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1C91_03170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1C91_03175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1C91_03180	COG0195	Participates in both transcription termination and antitermination
C1C91_03185	COG0779	Required for maturation of 30S ribosomal subunits
C1C91_03200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1C91_03205	COG0149	triose-phosphate isomerase activity
C1C91_03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1C91_03215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1C91_03220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1C91_03225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1C91_03230	COG1534	Rna-binding protein
C1C91_03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C91_03245	COG1360	Flagellar Motor Protein
C1C91_03250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C91_03255	COG1722	exodeoxyribonuclease VII activity
C1C91_03260	COG0142	geranyltranstransferase activity
C1C91_03265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1C91_03285	COG4172	Belongs to the ABC transporter superfamily
C1C91_03290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1C91_03295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1C91_03300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C91_03305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1C91_03320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C91_03320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C91_03325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1C91_03335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1C91_03350	COG3381	protein complex oligomerization
C1C91_03365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C91_03370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1C91_03375	COG0511	ligase activity, forming carbon-carbon bonds
C1C91_03380	COG0439	Biotin carboxylase
C1C91_03385	COG3924	membrane
C1C91_03390	COG4145	pantothenate transmembrane transporter activity
C1C91_03395	COG2190	(PTS) system
C1C91_03395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_03395	COG1263	PTS System
C1C91_03400	COG0583	DNA-binding transcription factor activity
C1C91_03405	COG0604	alcohol dehydrogenase
C1C91_03410	COG2264	protein methyltransferase activity
C1C91_03415	COG0110	maltose O-acetyltransferase activity
C1C91_03430	COG0778	Nitroreductase
C1C91_03440	COG0616	signal peptide processing
C1C91_03465	COG3139	Protein of unknown function (DUF1315)
C1C91_03470	COG0252	asparaginase activity
C1C91_03475	COG0786	glutamate:sodium symporter activity
C1C91_03500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1C91_03505	COG0384	phenazine biosynthesis protein PhzF
C1C91_03510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1C91_03515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C91_03520	COG0175	sulfate reduction
C1C91_03525	COG2113	Glycine betaine
C1C91_03530	COG4176	ABC-type proline glycine betaine transport system permease component
C1C91_03535	COG4175	Glycine betaine
C1C91_03545	COG3610	response to peptide
C1C91_03550	COG2966	Psort location CytoplasmicMembrane, score
C1C91_03560	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C91_03580	COG2313	pseudouridylate synthase activity
C1C91_03585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C91_03590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C91_03590	COG2146	nitrite reductase [NAD(P)H] activity
C1C91_03600	COG1116	anion transmembrane transporter activity
C1C91_03605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1C91_03610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1C91_03610	COG1116	anion transmembrane transporter activity
C1C91_03620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C91_03620	COG1648	precorrin-2 dehydrogenase activity
C1C91_03625	COG0243	molybdopterin cofactor binding
C1C91_03650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1C91_03670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_03695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1C91_03705	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C91_03715	COG4608	Belongs to the ABC transporter superfamily
C1C91_03720	COG0444	Belongs to the ABC transporter superfamily
C1C91_03730	COG4239	(ABC) transporter, permease
C1C91_03735	COG4174	ABC transporter (Permease)
C1C91_03740	COG4206	TonB-dependent receptor
C1C91_03750	COG0811	peptide transport
C1C91_03755	COG0811	peptide transport
C1C91_03760	COG0848	biopolymer transport protein
C1C91_03810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_03815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_03825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_03830	COG0840	transmembrane signaling receptor activity
C1C91_03840	COG1278	Cold shock
C1C91_03880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1C91_03885	COG1162	GTPase activity
C1C91_03890	COG0688	phosphatidylethanolamine metabolic process
C1C91_03895	COG4628	conserved protein (DUF2132)
C1C91_03915	COG3300	MHYT domain
C1C91_03915	COG5001	Diguanylate cyclase
C1C91_03920	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1C91_03945	COG1132	(ABC) transporter
C1C91_03960	COG2066	Belongs to the glutaminase family
C1C91_03965	COG3171	Protein conserved in bacteria
C1C91_03970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1C91_03975	COG4935	Belongs to the peptidase S8 family
C1C91_03975	COG2234	aminopeptidase activity
C1C91_03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C91_03985	COG2200	EAL domain
C1C91_03990	COG1090	epimerase
C1C91_03995	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1C91_04000	COG4181	ATPase activity
C1C91_04005	COG2755	lipolytic protein G-D-S-L family
C1C91_04010	COG0835	chemotaxis
C1C91_04010	COG0784	Response regulator, receiver
C1C91_04020	COG0675	Transposase, IS605 OrfB family
C1C91_04030	COG0517	IMP dehydrogenase activity
C1C91_04030	COG0516	GMP reductase activity
C1C91_04035	COG0488	(ABC) transporter
C1C91_04090	COG0789	Transcriptional regulator
C1C91_04100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C91_04110	COG0668	transmembrane transport
C1C91_04120	COG2731	YhcH YjgK YiaL family protein
C1C91_04135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C91_04145	COG1484	DNA-dependent DNA replication
C1C91_04150	COG4584	PFAM Integrase catalytic
C1C91_04160	COG0583	DNA-binding transcription factor activity
C1C91_04180	COG2985	domain, Protein
C1C91_04180	COG0569	domain protein
C1C91_04185	COG1272	protein, Hemolysin III
C1C91_04190	COG0076	glutamate decarboxylase activity
C1C91_04195	COG2917	probably involved in intracellular septation
C1C91_04200	COG2350	Protein conserved in bacteria
C1C91_04220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1C91_04225	COG3104	oligopeptide transport
C1C91_04275	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1C91_04280	COG1280	lysine exporter protein (LysE YggA)
C1C91_04330	COG2205	protein histidine kinase activity
C1C91_04335	COG0745	RESPONSE REGULATOR receiver
C1C91_04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_04345	COG1136	(ABC) transporter
C1C91_04345	COG0577	efflux transmembrane transporter activity
C1C91_04355	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C1C91_04390	COG2203	Gaf domain
C1C91_04390	COG2199	diguanylate cyclase activity
C1C91_04395	COG0513	Belongs to the DEAD box helicase family
C1C91_04405	COG2207	Transcriptional regulator
C1C91_04405	COG1917	Cupin 2, conserved barrel domain protein
C1C91_04430	COG0154	amidase activity
C1C91_04435	COG2957	Belongs to the agmatine deiminase family
C1C91_04450	COG1902	pentaerythritol trinitrate reductase activity
C1C91_04475	COG3706	GGDEF domain
C1C91_04475	COG0745	RESPONSE REGULATOR receiver
C1C91_04480	COG5001	Diguanylate cyclase
C1C91_04480	COG5002	protein histidine kinase activity
C1C91_04485	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1C91_04500	COG0456	acetyltransferase
C1C91_04510	COG1022	Amp-dependent synthetase and ligase
C1C91_04520	COG1794	racemase activity, acting on amino acids and derivatives
C1C91_04535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C91_04550	COG0733	neurotransmitter:sodium symporter activity
C1C91_04555	COG0733	neurotransmitter:sodium symporter activity
C1C91_04570	COG0561	phosphatase activity
C1C91_04585	COG1522	sequence-specific DNA binding
C1C91_04600	COG1846	Transcriptional regulator
C1C91_04605	COG2130	NADP-dependent
C1C91_04610	COG1051	belongs to the nudix hydrolase family
C1C91_04635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1C91_04640	COG1640	4-alpha-glucanotransferase
C1C91_04645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C91_04650	COG0676	glucose-6-phosphate 1-epimerase activity
C1C91_04655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1C91_04660	COG0840	transmembrane signaling receptor activity
C1C91_04735	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1C91_04740	COG2885	chlorophyll binding
C1C91_04745	COG0823	Involved in the tonB-independent uptake of proteins
C1C91_04760	COG0811	peptide transport
C1C91_04765	COG0824	Thioesterase
C1C91_04770	COG3790	cyd operon protein YbgE
C1C91_04775	COG4890	Cyd operon protein YbgT
C1C91_04780	COG1294	oxidase, subunit
C1C91_04785	COG1271	oxidase subunit
C1C91_04795	COG2255	four-way junction helicase activity
C1C91_04800	COG0632	four-way junction helicase activity
C1C91_04805	COG0840	transmembrane signaling receptor activity
C1C91_04810	COG0442	prolyl-tRNA aminoacylation
C1C91_04820	COG4221	oxidoreductase activity
C1C91_04835	COG1024	Enoyl-CoA hydratase
C1C91_04850	COG4166	transmembrane transport
C1C91_04860	COG0840	transmembrane signaling receptor activity
C1C91_04865	COG0513	Belongs to the DEAD box helicase family
C1C91_04900	COG0457	Tetratricopeptide repeat
C1C91_04900	COG3118	belongs to the thioredoxin family
C1C91_04910	COG1215	transferase activity, transferring glycosyl groups
C1C91_04935	COG1448	Aminotransferase
C1C91_04950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C91_04955	COG1328	CTP reductase activity
C1C91_04995	COG3397	chitin binding
C1C91_05000	COG0583	DNA-binding transcription factor activity
C1C91_05005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1C91_05010	COG4208	sulfate ABC transporter
C1C91_05015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1C91_05025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1C91_05055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1C91_05060	COG0564	pseudouridine synthase activity
C1C91_05080	COG0459	protein refolding
C1C91_05085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1C91_05095	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1C91_05100	COG1027	Aspartate ammonia-lyase
C1C91_05105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C91_05110	COG2918	glutathione biosynthetic process
C1C91_05115	COG0612	Peptidase, M16
C1C91_05120	COG1238	metal cluster binding
C1C91_05160	COG0359	binds to the 23S rRNA
C1C91_05165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1C91_05170	COG0360	Binds together with S18 to 16S ribosomal RNA
C1C91_05175	COG1914	H( )-stimulated, divalent metal cation uptake system
C1C91_05185	COG2153	protein acetylation
C1C91_05195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C91_05200	COG0557	exoribonuclease II activity
C1C91_05205	COG3706	GGDEF domain
C1C91_05210	COG1854	S-ribosylhomocysteine lyase activity
C1C91_05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C91_05225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1C91_05260	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1C91_05265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1C91_05270	COG1047	Peptidyl-prolyl cis-trans
C1C91_05275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1C91_05280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1C91_05285	COG0196	riboflavin kinase activity
C1C91_05290	COG0728	peptidoglycan biosynthetic process
C1C91_05295	COG0268	Binds directly to 16S ribosomal RNA
C1C91_05300	COG0640	Transcriptional regulator
C1C91_05305	COG0583	DNA-binding transcription factor activity
C1C91_05315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C91_05320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1C91_05325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1C91_05335	COG1051	belongs to the nudix hydrolase family
C1C91_05350	COG0335	large ribosomal subunit rRNA binding
C1C91_05355	COG0336	Belongs to the RNA methyltransferase TrmD family
C1C91_05360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1C91_05365	COG0228	four-way junction DNA binding
C1C91_05375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1C91_05380	COG4137	Cytochrome C assembly protein
C1C91_05385	COG4536	flavin adenine dinucleotide binding
C1C91_05395	COG1017	nitric oxide dioxygenase activity
C1C91_05395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C91_05400	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1C91_05410	COG0039	L-malate dehydrogenase activity
C1C91_05415	COG4160	amino acid transport
C1C91_05420	COG4215	(ABC) transporter
C1C91_05425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_05430	COG1126	abc transporter atp-binding protein
C1C91_05435	COG1438	arginine binding
C1C91_05440	COG2837	iron assimilation
C1C91_05445	COG3842	ATPase activity
C1C91_05455	COG1840	ABC-type Fe3 transport system, periplasmic component
C1C91_05460	COG0347	Belongs to the P(II) protein family
C1C91_05480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C91_05485	COG0583	DNA-binding transcription factor activity
C1C91_05500	COG1929	Belongs to the glycerate kinase type-1 family
C1C91_05505	COG2610	gluconate transmembrane transporter activity
C1C91_05510	COG3835	regulator
C1C91_05515	COG3112	Uncharacterised protein family (UPF0231)
C1C91_05535	COG1872	DUF167
C1C91_05540	COG0762	integral membrane protein
C1C91_05545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1C91_05550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1C91_05560	COG2805	Type II/IV secretion system protein
C1C91_05565	COG3022	response to hydroperoxide
C1C91_05570	COG0513	Belongs to the DEAD box helicase family
C1C91_05575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1C91_05595	COG0735	belongs to the Fur family
C1C91_05600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C91_05615	COG0776	regulation of translation
C1C91_05620	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1C91_05630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1C91_05645	COG0560	Phosphoserine phosphatase
C1C91_05655	COG5001	Diguanylate cyclase
C1C91_05655	COG3447	MASE1 domain protein
C1C91_05655	COG5002	protein histidine kinase activity
C1C91_05660	COG0813	purine-nucleoside phosphorylase activity
C1C91_05665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1C91_05670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1C91_05675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1C91_05685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C91_05690	COG0084	hydrolase, TatD family'
C1C91_05695	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1C91_05705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C91_05710	COG0004	ammonium transporteR
C1C91_05770	COG0582	viral genome integration into host DNA
C1C91_05785	COG0795	lipopolysaccharide-transporting ATPase activity
C1C91_05790	COG0795	lipopolysaccharide-transporting ATPase activity
C1C91_05795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C91_05800	COG2927	DNA polymerase III (CHI subunit)
C1C91_05805	COG0525	valine-tRNA ligase activity
C1C91_05810	COG1253	flavin adenine dinucleotide binding
C1C91_05815	COG0586	Pfam SNARE associated Golgi protein
C1C91_05820	COG1686	Belongs to the peptidase S11 family
C1C91_05855	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1C91_05860	COG0527	aspartate kinase activity
C1C91_05865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1C91_05870	COG2137	regulation of response to DNA damage stimulus
C1C91_05875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1C91_05880	COG1546	Belongs to the CinA family
C1C91_05890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1C91_05935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1C91_05940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1C91_05955	COG0477	Major facilitator Superfamily
C1C91_05960	COG0523	cobalamin synthesis protein
C1C91_05970	COG1280	lysine exporter protein (LysE YggA)
C1C91_05980	COG2200	EAL domain
C1C91_05985	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1C91_05990	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1C91_05995	COG0840	transmembrane signaling receptor activity
C1C91_06000	COG0840	transmembrane signaling receptor activity
C1C91_06010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C91_06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C91_06020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1C91_06025	COG2186	Transcriptional regulator
C1C91_06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C91_06060	COG1459	type II secretion system
C1C91_06075	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1C91_06080	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1C91_06085	COG0494	nUDIX hydrolase
C1C91_06095	COG0653	protein targeting
C1C91_06105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1C91_06110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1C91_06115	COG0849	cell division
C1C91_06120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1C91_06125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C91_06130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1C91_06135	COG0772	Belongs to the SEDS family
C1C91_06140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1C91_06145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C91_06150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1C91_06155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1C91_06160	COG0768	penicillin binding
C1C91_06165	COG3116	cell division
C1C91_06170	COG0275	rRNA processing
C1C91_06175	COG2001	Belongs to the MraZ family
C1C91_06185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1C91_06190	COG3107	peptidoglycan biosynthetic process
C1C91_06195	COG0792	nuclease activity
C1C91_06200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C91_06205	COG2823	Periplasmic or secreted lipoprotein
C1C91_06210	COG2969	positive regulation of protein catabolic process
C1C91_06215	COG0625	glutathione transferase activity
C1C91_06220	COG2857	Cytochrome c1
C1C91_06225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1C91_06230	COG0723	plastoquinol--plastocyanin reductase activity
C1C91_06235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1C91_06240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1C91_06245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1C91_06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C91_06260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C91_06310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_06315	COG1660	Displays ATPase and GTPase activities
C1C91_06320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_06330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1C91_06335	COG1137	ATPase activity
C1C91_06340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1C91_06350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1C91_06355	COG0517	IMP dehydrogenase activity
C1C91_06355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1C91_06360	COG1127	ABC transporter
C1C91_06365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1C91_06370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C91_06375	COG2854	intermembrane phospholipid transfer
C1C91_06385	COG5007	Belongs to the BolA IbaG family
C1C91_06390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1C91_06405	COG1494	fructose-1,6-bisphosphatase
C1C91_06435	COG0456	acetyltransferase
C1C91_06440	COG1733	regulation of RNA biosynthetic process
C1C91_06460	COG3932	Exopolysaccharide synthesis, ExoD
C1C91_06475	COG0110	maltose O-acetyltransferase activity
C1C91_06495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1C91_06505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1C91_06510	COG2022	thiamine diphosphate biosynthetic process
C1C91_06520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C91_06525	COG0352	thiamine-phosphate diphosphorylase activity
C1C91_06530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1C91_06545	COG0745	RESPONSE REGULATOR receiver
C1C91_06555	COG0189	ligase activity
C1C91_06600	COG0477	Major facilitator Superfamily
C1C91_06615	COG0312	modulator of DNA gyrase
C1C91_06620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C91_06625	COG3164	Protein of unknown function
C1C91_06630	COG1530	ribonuclease E activity
C1C91_06635	COG0424	maF-like protein
C1C91_06640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1C91_06645	COG1792	Involved in formation and maintenance of cell shape
C1C91_06650	COG1077	Cell shape determining protein MreB Mrl
C1C91_06700	COG1459	type II secretion system
C1C91_06760	COG0387	Pfam Sodium calcium exchanger
C1C91_06765	COG2986	histidine ammonia-lyase
C1C91_06770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1C91_06775	COG0010	Belongs to the arginase family
C1C91_06780	COG1228	amidohydrolase
C1C91_06785	COG2188	Transcriptional regulator
C1C91_06790	COG0288	reversible hydration of carbon dioxide
C1C91_06800	COG2177	Part of the ABC transporter FtsEX involved in
C1C91_06805	COG2884	Cell division ATP-binding protein ftsE
C1C91_06810	COG0552	protein localization to endoplasmic reticulum
C1C91_06815	COG0742	ribosomal rna small subunit methyltransferase
C1C91_06840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C91_06845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C91_06855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C91_06865	COG2095	MarC family integral membrane protein
C1C91_06875	COG1301	dicarboxylic acid transport
C1C91_06885	COG0583	DNA-binding transcription factor activity
C1C91_06900	COG3714	YhhN family
C1C91_06920	COG1770	oligopeptidase
C1C91_06935	COG4221	oxidoreductase activity
C1C91_06940	COG0583	DNA-binding transcription factor activity
C1C91_06945	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1C91_07005	COG0203	ribosomal protein L17
C1C91_07010	COG0202	RNA polymerase activity
C1C91_07015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1C91_07020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1C91_07025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1C91_07030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C91_07035	COG0201	protein transport
C1C91_07040	COG0200	Binds to the 23S rRNA
C1C91_07045	COG1841	ribosomal large subunit assembly
C1C91_07050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1C91_07055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1C91_07060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1C91_07065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1C91_07070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1C91_07075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1C91_07080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1C91_07085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1C91_07090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1C91_07095	COG0255	Belongs to the universal ribosomal protein uL29 family
C1C91_07100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1C91_07105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1C91_07110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1C91_07115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1C91_07120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1C91_07125	COG0089	rRNA binding
C1C91_07130	COG0088	Forms part of the polypeptide exit tunnel
C1C91_07135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1C91_07140	COG0051	transcription antitermination factor activity, RNA binding
C1C91_07150	COG2205	protein histidine kinase activity
C1C91_07155	COG0745	RESPONSE REGULATOR receiver
C1C91_07160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C91_07165	COG2183	response to ionizing radiation
C1C91_07180	COG0596	Alpha beta hydrolase
C1C91_07185	COG1040	competence protein
C1C91_07190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1C91_07190	COG0316	Belongs to the HesB IscA family
C1C91_07200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1C91_07205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1C91_07210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C91_07215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1C91_07220	COG4942	peptidase
C1C91_07230	COG1609	Transcriptional regulator
C1C91_07245	COG0800	Aldolase
C1C91_07250	COG0129	dihydroxy-acid dehydratase activity
C1C91_07255	COG3265	gluconokinase activity
C1C91_07265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C91_07270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1C91_07280	COG0456	acetyltransferase
C1C91_07290	COG1490	D-aminoacyl-tRNA deacylase activity
C1C91_07295	COG1295	ribonuclease BN
C1C91_07305	COG0174	glutamine synthetase
C1C91_07315	COG3852	Histidine kinase
C1C91_07325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C91_07330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C91_07340	COG3078	GTPase activator activity
C1C91_07350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1C91_07360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1C91_07365	COG0408	coproporphyrinogen oxidase activity
C1C91_07370	COG0009	L-threonylcarbamoyladenylate synthase
C1C91_07375	COG0551	DNA topoisomerase type I activity
C1C91_07380	COG2922	Belongs to the Smg family
C1C91_07385	COG0758	DNA mediated transformation
C1C91_07395	COG0242	peptide deformylase activity
C1C91_07400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1C91_07405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C91_07405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C91_07415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C91_07420	COG1322	Protein conserved in bacteria
C1C91_07440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C91_07450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C91_07450	COG0519	Catalyzes the synthesis of GMP from XMP
C1C91_07465	COG1396	sequence-specific DNA binding
C1C91_07470	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_07475	COG2962	Rard protein
C1C91_07485	COG1280	lysine exporter protein (LysE YggA)
C1C91_07525	COG0583	DNA-binding transcription factor activity
C1C91_07535	COG0210	DNA helicase
C1C91_07570	COG0583	DNA-binding transcription factor activity
C1C91_07595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1C91_07600	COG0385	Bile acid
C1C91_07605	COG0531	amino acid
C1C91_07610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C91_07620	COG2801	Transposase and inactivated derivatives
C1C91_07630	COG2731	YhcH YjgK YiaL family protein
C1C91_07635	COG3250	beta-galactosidase activity
C1C91_07640	COG1609	Transcriptional regulator
C1C91_07675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1C91_07680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C91_07680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C91_07685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1C91_07690	COG3074	FtsZ-dependent cytokinesis
C1C91_07710	COG0745	RESPONSE REGULATOR receiver
C1C91_07715	COG2205	protein histidine kinase activity
C1C91_07720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1C91_07725	COG0534	Mate efflux family protein
C1C91_07740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C91_07745	COG2937	Belongs to the GPAT DAPAT family
C1C91_07750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1C91_07755	COG3161	chorismate lyase activity
C1C91_07760	COG1580	Controls the rotational direction of flagella during chemotaxis
C1C91_07780	COG1609	Transcriptional regulator
C1C91_07825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C91_07835	COG0156	8-amino-7-oxononanoate synthase activity
C1C91_07840	COG1063	alcohol dehydrogenase
C1C91_07860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1C91_07865	COG2166	iron-sulfur cluster assembly
C1C91_07870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1C91_07925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1C91_07930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1C91_07935	COG2223	nitrite transmembrane transporter activity
C1C91_07940	COG3279	Response regulator of the LytR AlgR family
C1C91_07945	COG3275	phosphorelay sensor kinase activity
C1C91_07965	COG3039	Transposase
C1C91_07980	COG1280	lysine exporter protein (LysE YggA)
C1C91_07985	COG2223	nitrite transmembrane transporter activity
C1C91_07990	COG2081	HI0933 family
C1C91_07995	COG1528	Iron-storage protein
C1C91_08000	COG3706	GGDEF domain
C1C91_08005	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C91_08010	COG0589	response to stress
C1C91_08050	COG3642	lipopolysaccharide core region biosynthetic process
C1C91_08055	COG0859	PFAM glycosyl transferase family 9
C1C91_08070	COG1758	RNA polymerase activity
C1C91_08075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C91_08080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C91_08085	COG0110	maltose O-acetyltransferase activity
C1C91_08090	COG2267	carboxylic ester hydrolase activity
C1C91_08095	COG0561	phosphatase activity
C1C91_08125	COG1309	transcriptional regulator
C1C91_08130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_08135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C91_08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_08140	COG4191	Histidine kinase
C1C91_08145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C91_08170	COG2205	protein histidine kinase activity
C1C91_08175	COG0745	RESPONSE REGULATOR receiver
C1C91_08195	COG3977	Valine--pyruvate aminotransferase
C1C91_08200	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C91_08205	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C91_08210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1C91_08215	COG2207	Transcriptional regulator
C1C91_08220	COG2801	Transposase and inactivated derivatives
C1C91_08225	COG0187	DNA topoisomerase II activity
C1C91_08235	COG0592	DNA-directed DNA polymerase activity
C1C91_08240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1C91_08260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1C91_08265	COG0594	ribonuclease P activity
C1C91_08270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1C91_08275	COG0706	membrane insertase activity
C1C91_08280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1C91_08285	COG4974	Belongs to the 'phage' integrase family
C1C91_08335	COG3550	peptidyl-serine autophosphorylation
C1C91_08340	COG3385	transposase activity
C1C91_08350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C91_08355	COG1120	ATPase activity
C1C91_08360	COG4615	Cyclic peptide transporter
C1C91_08365	COG4774	siderophore transport
C1C91_08370	COG0716	FMN binding
C1C91_08375	COG0445	tRNA wobble uridine modification
C1C91_08380	COG0357	Ribosomal RNA small subunit methyltransferase G
C1C91_08385	COG1192	Involved in chromosome partitioning
C1C91_08390	COG1475	DNA binding
C1C91_08400	COG0356	it plays a direct role in the translocation of protons across the membrane
C1C91_08410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1C91_08415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1C91_08420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1C91_08425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1C91_08430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1C91_08435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1C91_08440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1C91_08445	COG4452	Inner membrane protein CreD
C1C91_08455	COG2205	protein histidine kinase activity
C1C91_08460	COG0745	RESPONSE REGULATOR receiver
C1C91_08465	COG1349	DNA-binding transcription factor activity
C1C91_08470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1C91_08575	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C91_08580	COG0542	response to heat
C1C91_08600	COG0501	Belongs to the peptidase M48B family
C1C91_08605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C91_08610	COG2771	luxR family
C1C91_08620	COG0811	peptide transport
C1C91_08625	COG0811	peptide transport
C1C91_08630	COG0848	biopolymer transport protein
C1C91_08635	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1C91_08670	COG0402	S-adenosylhomocysteine deaminase activity
C1C91_08675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1C91_08685	COG3165	ubiquinone biosynthetic process from chorismate
C1C91_08690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1C91_08695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C91_08700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C91_08705	COG0805	protein transport
C1C91_08730	COG0742	ribosomal rna small subunit methyltransferase
C1C91_08745	COG0248	Ppx GppA phosphatase
C1C91_08750	COG0513	Belongs to the DEAD box helicase family
C1C91_08755	COG3118	belongs to the thioredoxin family
C1C91_08760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1C91_08770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1C91_08780	COG2960	long-chain fatty acid transporting porin activity
C1C91_08795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C91_08825	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1C91_08835	COG1609	Transcriptional regulator
C1C91_08840	COG3604	Transcriptional regulator
C1C91_08845	COG1773	rubredoxin
C1C91_08845	COG0426	domain, Protein
C1C91_08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C91_08860	COG0348	domain, Protein
C1C91_08875	COG0814	amino acid
C1C91_08880	COG0814	amino acid
C1C91_08905	COG0751	glycine-tRNA ligase activity
C1C91_08910	COG0752	glycyl-tRNA synthetase alpha subunit
C1C91_08915	COG2818	Glycosylase
C1C91_08920	COG1335	isochorismatase
C1C91_08930	COG2885	chlorophyll binding
C1C91_08945	COG0251	oxidation-reduction process
C1C91_08950	COG0425	Belongs to the sulfur carrier protein TusA family
C1C91_08980	COG2205	protein histidine kinase activity
C1C91_08985	COG0745	RESPONSE REGULATOR receiver
C1C91_08990	COG0183	Belongs to the thiolase family
C1C91_08995	COG1024	Enoyl-CoA hydratase
C1C91_08995	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1C91_09000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C91_09005	COG0006	proline dipeptidase activity
C1C91_09010	COG1739	Uncharacterized protein family UPF0029
C1C91_09015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C91_09020	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1C91_09045	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C91_09045	COG1042	CoA-binding domain protein
C1C91_09045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C91_09060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1C91_09065	COG0166	Belongs to the GPI family
C1C91_09075	COG0668	transmembrane transport
C1C91_09090	COG1309	transcriptional regulator
C1C91_09095	COG0756	dUTP diphosphatase activity
C1C91_09100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1C91_09105	COG2003	Belongs to the UPF0758 family
C1C91_09110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1C91_09115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1C91_09125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1C91_09130	COG2990	Protein conserved in bacteria
C1C91_09135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1C91_09140	COG0859	PFAM glycosyl transferase family 9
C1C91_09150	COG0859	PFAM glycosyl transferase family 9
C1C91_09155	COG1519	Transferase
C1C91_09190	COG1857	crispr-associated protein
C1C91_09205	COG1518	maintenance of DNA repeat elements
C1C91_09210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C91_09275	COG1561	YicC-like family, N-terminal region
C1C91_09280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1C91_09285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1C91_09300	COG3706	GGDEF domain
C1C91_09300	COG4251	negative regulation of phosphorylation
C1C91_09300	COG5001	Diguanylate cyclase
C1C91_09300	COG2203	Gaf domain
C1C91_09305	COG3084	Protein conserved in bacteria
C1C91_09315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1C91_09320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1C91_09325	COG3639	organic phosphonate transmembrane transporter activity
C1C91_09330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1C91_09335	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1C91_09345	COG1335	isochorismatase
C1C91_09355	COG1683	Conserved Protein
C1C91_09360	COG0204	Acyl-transferase
C1C91_09385	COG3978	acetolactate synthase activity
C1C91_09390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1C91_09395	COG0129	dihydroxy-acid dehydratase activity
C1C91_09410	COG3385	transposase activity
C1C91_09420	COG1309	transcriptional regulator
C1C91_09430	COG0254	rRNA binding
C1C91_09435	COG0702	epimerase
C1C91_09440	COG0281	malic enzyme
C1C91_09450	COG2205	protein histidine kinase activity
C1C91_09500	COG4310	Domain of unknown function (DUF2172)
C1C91_09510	COG0366	Alpha amylase catalytic
C1C91_09525	COG0443	Heat shock 70 kDa protein
C1C91_09530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C91_09535	COG3045	CreA protein
C1C91_09550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1C91_09555	COG0174	glutamine synthetase
C1C91_09575	COG3842	ATPase activity
C1C91_09580	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C91_09585	COG1177	transmembrane transport
C1C91_09590	COG2258	MOSC domain
C1C91_09605	COG2050	protein possibly involved in aromatic compounds catabolism
C1C91_09610	COG0514	ATP-dependent DNA helicase (RecQ)
C1C91_09620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1C91_09630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1C91_09635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C91_09640	COG2239	Acts as a magnesium transporter
C1C91_09645	COG1648	precorrin-2 dehydrogenase activity
C1C91_09645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C91_09650	COG2116	formate transmembrane transporter activity
C1C91_09655	COG2146	nitrite reductase [NAD(P)H] activity
C1C91_09660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C91_09665	COG0842	Transport permease protein
C1C91_09670	COG0842	Transport permease protein
C1C91_09675	COG1131	(ABC) transporter
C1C91_09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_09700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1C91_09705	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1C91_09725	COG1595	DNA-templated transcription, initiation
C1C91_09730	COG3806	Anti-sigma factor
C1C91_09735	COG1968	undecaprenyl-diphosphatase activity
C1C91_09740	COG0667	Aldo Keto reductase
C1C91_09745	COG2017	converts alpha-aldose to the beta-anomer
C1C91_09750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1C91_09760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C91_09765	COG1609	Transcriptional regulator
C1C91_09770	COG3250	beta-galactosidase activity
C1C91_09810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1C91_09815	COG1288	antiporter activity
C1C91_09820	COG1438	arginine binding
C1C91_09825	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C1C91_09830	COG0540	Belongs to the ATCase OTCase family
C1C91_09865	COG3040	lipid binding
C1C91_09875	COG1979	alcohol dehydrogenase
C1C91_09880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1C91_09885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1C91_09890	COG3385	transposase activity
C1C91_09895	COG2964	Protein conserved in bacteria
C1C91_09900	COG3681	Belongs to the UPF0597 family
C1C91_09905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C91_09910	COG0564	pseudouridine synthase activity
C1C91_09920	COG0542	response to heat
C1C91_09925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1C91_09930	COG2502	aspartate--ammonia ligase
C1C91_09935	COG1522	sequence-specific DNA binding
C1C91_09945	COG0516	GMP reductase activity
C1C91_09945	COG0517	IMP dehydrogenase activity
C1C91_09965	COG2205	protein histidine kinase activity
C1C91_09975	COG2204	response regulator
C1C91_09990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1C91_10010	COG0745	RESPONSE REGULATOR receiver
C1C91_10015	COG2205	protein histidine kinase activity
C1C91_10025	COG0243	molybdopterin cofactor binding
C1C91_10030	COG3005	denitrification pathway
C1C91_10035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1C91_10045	COG0569	domain protein
C1C91_10050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1C91_10075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C91_10085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1C91_10090	COG0250	Participates in transcription elongation, termination and antitermination
C1C91_10095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1C91_10100	COG0081	regulation of translation
C1C91_10105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1C91_10110	COG0222	ribosome binding
C1C91_10115	COG0085	RNA polymerase activity
C1C91_10120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1C91_10125	COG2964	Protein conserved in bacteria
C1C91_10130	COG0251	oxidation-reduction process
C1C91_10135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C91_10145	COG2168	tRNA wobble position uridine thiolation
C1C91_10150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1C91_10155	COG0049	tRNA binding
C1C91_10160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1C91_10165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C91_10170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C91_10205	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C1C91_10210	COG2252	PERMEase
C1C91_10215	COG2376	Dihydroxyacetone kinase
C1C91_10220	COG1461	Dihydroxyacetone kinase
C1C91_10235	COG0583	DNA-binding transcription factor activity
C1C91_10240	COG2957	Belongs to the agmatine deiminase family
C1C91_10265	COG0628	permease
C1C91_10270	COG0494	nUDIX hydrolase
C1C91_10290	COG0753	catalase activity
C1C91_10295	COG0456	acetyltransferase
C1C91_10315	COG0745	RESPONSE REGULATOR receiver
C1C91_10315	COG3706	GGDEF domain
C1C91_10325	COG3842	ATPase activity
C1C91_10335	COG1175	transmembrane transport
C1C91_10360	COG0583	DNA-binding transcription factor activity
C1C91_10370	COG1741	Belongs to the pirin family
C1C91_10375	COG2259	Doxx family
C1C91_10380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1C91_10385	COG1074	ATP-dependent DNA helicase activity
C1C91_10390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C91_10400	COG0004	ammonium transporteR
C1C91_10405	COG0347	Belongs to the P(II) protein family
C1C91_10410	COG3706	GGDEF domain
C1C91_10430	COG0745	RESPONSE REGULATOR receiver
C1C91_10435	COG2205	protein histidine kinase activity
C1C91_10440	COG3385	transposase activity
C1C91_10445	COG1278	Cold shock
C1C91_10470	COG2197	response regulator
C1C91_10475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1C91_10480	COG3047	cAMP biosynthetic process
C1C91_10510	COG3135	benzoate transporter
C1C91_10515	COG1396	sequence-specific DNA binding
C1C91_10545	COG2926	Belongs to the UPF0265 family
C1C91_10555	COG3028	Belongs to the UPF0307 family
C1C91_10560	COG0312	modulator of DNA gyrase
C1C91_10565	COG3071	HemY protein
C1C91_10570	COG2959	enzyme of heme biosynthesis
C1C91_10580	COG0181	hydroxymethylbilane synthase activity
C1C91_10585	COG3072	Adenylate cyclase
C1C91_10590	COG0400	carboxylic ester hydrolase activity
C1C91_10595	COG1965	Belongs to the frataxin family
C1C91_10605	COG0019	diaminopimelate decarboxylase activity
C1C91_10610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1C91_10625	COG1011	Hydrolase
C1C91_10635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1C91_10640	COG0561	phosphatase activity
C1C91_10655	COG1988	membrane-bound metal-dependent
C1C91_10660	COG1058	Belongs to the CinA family
C1C91_10660	COG1546	Belongs to the CinA family
C1C91_10670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1C91_10680	COG1522	sequence-specific DNA binding
C1C91_10685	COG1368	sulfuric ester hydrolase activity
C1C91_10700	COG1285	pathogenesis
C1C91_10720	COG4221	oxidoreductase activity
C1C91_10735	COG1979	alcohol dehydrogenase
C1C91_10745	COG2873	o-acetylhomoserine
C1C91_10775	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1C91_10790	COG2949	membrane
C1C91_10795	COG3291	Pkd domain containing protein
C1C91_10810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1C91_10815	COG0596	Alpha beta hydrolase
C1C91_10820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1C91_10850	COG0513	Belongs to the DEAD box helicase family
C1C91_10855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C91_10870	COG1671	Belongs to the UPF0178 family
C1C91_10890	COG3263	regulation of cellular component size
C1C91_10895	COG3722	fumarate hydratase activity
C1C91_10900	COG0246	Mannitol dehydrogenase
C1C91_10905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_10905	COG2213	PTS system mannitol-specific
C1C91_10910	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1C91_10925	COG2771	luxR family
C1C91_10940	COG1560	Kdo2-lipid A biosynthetic process
C1C91_10950	COG1538	Outer membrane efflux protein
C1C91_10955	COG0494	nUDIX hydrolase
C1C91_10960	COG3151	Protein conserved in bacteria
C1C91_10970	COG3150	esterase
C1C91_10990	COG1566	PFAM secretion protein HlyD family protein
C1C91_10995	COG1289	transmembrane transporter activity
C1C91_11000	COG0187	DNA topoisomerase II activity
C1C91_11060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C91_11085	COG0204	Acyl-transferase
C1C91_11090	COG1842	Phage shock protein A
C1C91_11105	COG2827	Endonuclease containing a URI domain
C1C91_11110	COG2962	Rard protein
C1C91_11115	COG1573	uracil-dna glycosylase
C1C91_11130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1C91_11135	COG1121	(ABC) transporter
C1C91_11140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1C91_11160	COG0739	heme binding
C1C91_11170	COG3068	Protein conserved in bacteria
C1C91_11195	COG5006	permease, DMT superfamily
C1C91_11200	COG1522	sequence-specific DNA binding
C1C91_11205	COG0110	maltose O-acetyltransferase activity
C1C91_11210	COG0366	Alpha amylase catalytic
C1C91_11215	COG1263	PTS System
C1C91_11215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_11235	COG0252	asparaginase activity
C1C91_11250	COG1803	Methylglyoxal synthase
C1C91_11270	COG1444	tRNA N-acetyltransferase activity
C1C91_11275	COG1565	acr, cog1565
C1C91_11275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C91_11285	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1C91_11310	COG0109	protoheme IX farnesyltransferase activity
C1C91_11315	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_11320	COG1177	transmembrane transport
C1C91_11325	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C91_11330	COG3842	ATPase activity
C1C91_11335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1C91_11340	COG0583	DNA-binding transcription factor activity
C1C91_11345	COG1757	Na H antiporter
C1C91_11385	COG0297	glycogen (starch) synthase activity
C1C91_11390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1C91_11395	COG2813	Specifically methylates the guanine in position
C1C91_11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C91_11405	COG2203	Gaf domain
C1C91_11405	COG3706	GGDEF domain
C1C91_11405	COG5001	Diguanylate cyclase
C1C91_11405	COG4251	negative regulation of phosphorylation
C1C91_11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C91_11420	COG2995	paraquat-inducible protein a
C1C91_11425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C91_11425	COG3008	intermembrane lipid transfer
C1C91_11430	COG3009	Protein conserved in bacteria
C1C91_11440	COG3240	lipase activity
C1C91_11455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1C91_11460	COG1194	a g-specific adenine glycosylase
C1C91_11470	COG3267	Type II secretory pathway component ExeA
C1C91_11470	COG3409	Peptidoglycan-binding domain 1 protein
C1C91_11475	COG0617	tRNA 3'-terminal CCA addition
C1C91_11480	COG0306	phosphate transporter
C1C91_11485	COG1392	Phosphate transport regulator
C1C91_11490	COG3025	triphosphatase activity
C1C91_11495	COG3133	Outer membrane lipoprotein
C1C91_11500	COG0456	acetyltransferase
C1C91_11515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1C91_11520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1C91_11530	COG3031	protein transport across the cell outer membrane
C1C91_11540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C91_11545	COG1459	type II secretion system
C1C91_11550	COG2165	general secretion pathway protein
C1C91_11560	COG2165	general secretion pathway protein
C1C91_11565	COG4795	General secretion pathway protein
C1C91_11570	COG3156	type II secretion system protein K
C1C91_11580	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1C91_11595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C91_11610	COG1011	Hydrolase
C1C91_11615	COG0494	nUDIX hydrolase
C1C91_11620	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1C91_11630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C91_11645	COG0626	cystathionine gamma-synthase activity
C1C91_11650	COG0527	aspartate kinase activity
C1C91_11650	COG0460	homoserine dehydrogenase
C1C91_11655	COG1346	cytolysis
C1C91_11660	COG1380	Effector of murein hydrolase LrgA
C1C91_11665	COG0583	DNA-binding transcription factor activity
C1C91_11700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1C91_11705	COG5001	Diguanylate cyclase
C1C91_11705	COG3447	MASE1 domain protein
C1C91_11705	COG5002	protein histidine kinase activity
C1C91_11710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1C91_11720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1C91_11725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C91_11735	COG0137	argininosuccinate synthase activity
C1C91_11745	COG0165	Argininosuccinate lyase
C1C91_11750	COG0583	DNA-binding transcription factor activity
C1C91_11760	COG1942	4-Oxalocrotonate Tautomerase
C1C91_11790	COG0110	maltose O-acetyltransferase activity
C1C91_11795	COG3174	membrane
C1C91_11800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_11805	COG1126	abc transporter atp-binding protein
C1C91_11810	COG0765	amino acid transport
C1C91_11815	COG0765	amino acid transport
C1C91_11820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C91_11825	COG1505	serine-type exopeptidase activity
C1C91_11835	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_11840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1C91_11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C91_11860	COG4991	sh3 domain protein
C1C91_11865	COG2816	NAD+ diphosphatase activity
C1C91_11870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1C91_11875	COG1940	carbohydrate kinase activity
C1C91_11880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C91_11885	COG0126	phosphoglycerate kinase activity
C1C91_11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C91_11905	COG4232	protein-disulfide reductase activity
C1C91_11925	COG0583	DNA-binding transcription factor activity
C1C91_11940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1C91_11950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1C91_11955	COG1595	DNA-templated transcription, initiation
C1C91_11960	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1C91_11975	COG0481	GTPase activity
C1C91_11980	COG0681	Belongs to the peptidase S26 family
C1C91_11985	COG0571	ribonuclease III activity
C1C91_11995	COG1381	Involved in DNA repair and RecF pathway recombination
C1C91_12000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1C91_12005	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1C91_12010	COG4807	Protein conserved in bacteria
C1C91_12020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C91_12025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C91_12030	COG3956	TIGRFAM MazG family protein
C1C91_12035	COG0504	CTP synthase activity
C1C91_12040	COG0148	phosphopyruvate hydratase activity
C1C91_12045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1C91_12050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1C91_12060	COG0585	pseudouridine synthase activity
C1C91_12065	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1C91_12070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1C91_12075	COG1238	metal cluster binding
C1C91_12090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1C91_12095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1C91_12100	COG1610	YqeY-like protein
C1C91_12105	COG0358	DNA primase activity
C1C91_12110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1C91_12145	COG0151	Belongs to the GarS family
C1C91_12150	COG0138	bifunctional purine biosynthesis protein purh
C1C91_12165	COG3036	rescue of stalled ribosome
C1C91_12175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C91_12180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1C91_12190	COG0673	inositol 2-dehydrogenase activity
C1C91_12200	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1C91_12205	COG0330	HflC and HflK could
C1C91_12210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C91_12210	COG1648	precorrin-2 dehydrogenase activity
C1C91_12215	COG0175	sulfate reduction
C1C91_12220	COG2895	sulfate adenylyltransferase (ATP) activity
C1C91_12225	COG3273	potassium ion transport
C1C91_12225	COG0471	metal ion transport
C1C91_12230	COG0529	Catalyzes the synthesis of activated sulfate
C1C91_12270	COG1136	(ABC) transporter
C1C91_12285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1C91_12300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1C91_12305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C91_12310	COG0163	prenyltransferase activity
C1C91_12325	COG1131	(ABC) transporter
C1C91_12340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1C91_12345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1C91_12350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1C91_12360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C91_12365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1C91_12370	COG1489	DNA binding
C1C91_12380	COG1643	Atp-dependent helicase
C1C91_12385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C91_12390	COG0346	lactoylglutathione lyase activity
C1C91_12400	COG2076	Multidrug Resistance protein
C1C91_12405	COG0583	DNA-binding transcription factor activity
C1C91_12415	COG0671	phosphoesterase, PA-phosphatase related
C1C91_12430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1C91_12435	COG0038	chloride channel
C1C91_12475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C91_12485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1C91_12490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1C91_12495	COG1178	ABC-type Fe3 transport system permease component
C1C91_12515	COG0066	3-isopropylmalate dehydratase activity
C1C91_12520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1C91_12525	COG0473	3-isopropylmalate dehydrogenase activity
C1C91_12530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C91_12555	COG0028	Belongs to the TPP enzyme family
C1C91_12560	COG0440	acetolactate synthase activity
C1C91_12565	COG0857	belongs to the CobB CobQ family
C1C91_12565	COG0280	phosphate acetyltransferase
C1C91_12570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1C91_12575	COG3092	negative regulation of chromosome organization
C1C91_12580	COG3013	Belongs to the UPF0304 family
C1C91_12585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1C91_12590	COG2716	regulation of RNA biosynthetic process
C1C91_12595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C91_12600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1C91_12605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1C91_12620	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1C91_12640	COG2198	Histidine kinase
C1C91_12640	COG0784	Response regulator, receiver
C1C91_12640	COG5002	protein histidine kinase activity
C1C91_12655	COG2205	protein histidine kinase activity
C1C91_12655	COG0784	Response regulator, receiver
C1C91_12675	COG1464	Belongs to the NlpA lipoprotein family
C1C91_12680	COG2011	ABC-type metal ion transport system permease component
C1C91_12685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1C91_12705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1C91_12705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1C91_12710	COG0802	atpase or kinase
C1C91_12720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1C91_12725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1C91_12730	COG1923	regulation of RNA biosynthetic process
C1C91_12735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1C91_12740	COG0330	HflC and HflK could
C1C91_12745	COG0330	HflC and HflK could
C1C91_12750	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1C91_12755	COG0142	geranyltranstransferase activity
C1C91_12760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1C91_12765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1C91_12770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1C91_12780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C91_12785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1C91_12795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1C91_12805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1C91_12820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1C91_12825	COG3178	'Phosphotransferase
C1C91_12830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1C91_12835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C91_12840	COG2252	PERMEase
C1C91_12850	COG0488	(ABC) transporter
C1C91_12855	COG0741	lytic transglycosylase activity
C1C91_12865	COG0463	Glycosyl transferase, family 2
C1C91_12875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1C91_12900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C91_12910	COG3721	Heme iron utilization protein
C1C91_12915	COG0748	coenzyme F420 binding
C1C91_12940	COG2814	Major facilitator Superfamily
C1C91_12945	COG2205	protein histidine kinase activity
C1C91_12945	COG2202	Pas domain
C1C91_12955	COG2226	methyltransferase
C1C91_12960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C91_12965	COG1765	OsmC-like protein
C1C91_12980	COG3954	Phosphoribulokinase
C1C91_12985	COG3089	Belongs to the UPF0270 family
C1C91_12990	COG3706	GGDEF domain
C1C91_12990	COG5001	Diguanylate cyclase
C1C91_12990	COG2203	Gaf domain
C1C91_12990	COG4251	negative regulation of phosphorylation
C1C91_12995	COG0429	hydrolase of the alpha beta-hydrolase fold
C1C91_13000	COG0835	chemotaxis
C1C91_13000	COG0784	Response regulator, receiver
C1C91_13010	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1C91_13015	COG1047	Peptidyl-prolyl cis-trans
C1C91_13020	COG2900	Belongs to the SlyX family
C1C91_13030	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C91_13035	COG2204	response regulator
C1C91_13055	COG0737	Belongs to the 5'-nucleotidase family
C1C91_13065	COG0305	Participates in initiation and elongation during chromosome replication
C1C91_13070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C91_13075	COG0506	proline dehydrogenase activity
C1C91_13075	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C91_13075	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C91_13085	COG0114	fumarate hydratase activity
C1C91_13095	COG1966	Carbon starvation protein
C1C91_13100	COG3279	Response regulator of the LytR AlgR family
C1C91_13105	COG3275	phosphorelay sensor kinase activity
C1C91_13115	COG2199	diguanylate cyclase activity
C1C91_13115	COG2200	EAL domain
C1C91_13115	COG2203	Gaf domain
C1C91_13150	COG1280	lysine exporter protein (LysE YggA)
C1C91_13155	COG0826	peptidase U32
C1C91_13165	COG3813	Protein conserved in bacteria
C1C91_13185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1C91_13210	COG0300	oxidoreductase activity
C1C91_13230	COG2610	gluconate transmembrane transporter activity
C1C91_13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C91_13240	COG3622	Belongs to the hyi family
C1C91_13245	COG0235	Class ii aldolase
C1C91_13255	COG2084	Dehydrogenase
C1C91_13260	COG1349	DNA-binding transcription factor activity
C1C91_13270	COG2133	pyrroloquinoline quinone binding
C1C91_13300	COG0077	Prephenate dehydratase
C1C91_13300	COG1605	Chorismate mutase
C1C91_13325	COG3272	Protein of unknown function (DUF1722)
C1C91_13330	COG0789	Transcriptional regulator
C1C91_13335	COG0415	Belongs to the DNA photolyase family
C1C91_13345	COG4221	oxidoreductase activity
C1C91_13360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1C91_13385	COG0783	Belongs to the Dps family
C1C91_13390	COG1151	hydroxylamine reductase activity
C1C91_13400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C91_13420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C91_13425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_13435	COG5002	protein histidine kinase activity
C1C91_13435	COG5000	phosphorelay sensor kinase activity
C1C91_13440	COG0659	secondary active sulfate transmembrane transporter activity
C1C91_13450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1C91_13455	COG1666	GTP binding
C1C91_13460	COG3248	Nucleoside-binding outer membrane protein
C1C91_13465	COG2211	Major facilitator Superfamily
C1C91_13475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C91_13485	COG2813	Specifically methylates the guanine in position
C1C91_13490	COG0271	Belongs to the BolA IbaG family
C1C91_13495	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C91_13500	COG1805	sodium ion transport
C1C91_13505	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C91_13510	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C91_13515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C91_13520	COG2871	sodium ion transport
C1C91_13525	COG1477	protein flavinylation
C1C91_13540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C91_13545	COG0840	transmembrane signaling receptor activity
C1C91_13550	COG0583	DNA-binding transcription factor activity
C1C91_13565	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1C91_13575	COG0473	3-isopropylmalate dehydrogenase activity
C1C91_13580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C91_13585	COG1611	Belongs to the LOG family
C1C91_13590	COG3706	GGDEF domain
C1C91_13600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C91_13600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C91_13610	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1C91_13635	COG3098	single-species biofilm formation
C1C91_13640	COG0564	pseudouridine synthase activity
C1C91_13650	COG4580	involved in the transport of maltose and maltodextrins
C1C91_13660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_13660	COG1263	PTS System
C1C91_13670	COG2171	N-acyltransferase activity
C1C91_13675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1C91_13680	COG0024	Methionine aminopeptidase
C1C91_13685	COG0052	Belongs to the universal ribosomal protein uS2 family
C1C91_13690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1C91_13695	COG0528	UMP kinase activity
C1C91_13700	COG0233	cytoplasmic translational termination
C1C91_13710	COG0575	Belongs to the CDS family
C1C91_13715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1C91_13720	COG0750	zinc metalloprotease
C1C91_13735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C91_13740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C91_13745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C91_13750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C91_13755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1C91_13765	COG0825	malonyl-CoA metabolic process
C1C91_13780	COG0814	amino acid
C1C91_13785	COG0531	amino acid
C1C91_13795	COG0488	(ABC) transporter
C1C91_13810	COG0037	tRNA processing
C1C91_13815	COG3706	GGDEF domain
C1C91_13860	COG0366	Alpha amylase catalytic
C1C91_13875	COG0463	Glycosyl transferase, family 2
C1C91_13890	COG2989	Protein conserved in bacteria
C1C91_13895	COG3385	transposase activity
C1C91_13900	COG3108	Peptidase M15
C1C91_13910	COG2860	membrane
C1C91_13925	COG3115	cell septum assembly
C1C91_13930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1C91_13940	COG1328	CTP reductase activity
C1C91_13945	COG0602	queuosine metabolic process
C1C91_13970	COG1566	PFAM secretion protein HlyD family protein
C1C91_13980	COG3290	protein histidine kinase activity
C1C91_13990	COG3385	transposase activity
C1C91_14000	COG0667	Aldo Keto reductase
C1C91_14005	COG0697	spore germination
C1C91_14015	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_14025	COG3706	GGDEF domain
C1C91_14030	COG0346	lactoylglutathione lyase activity
C1C91_14035	COG0745	RESPONSE REGULATOR receiver
C1C91_14050	COG4783	chaperone-mediated protein folding
C1C91_14065	COG3142	Participates in the control of copper homeostasis
C1C91_14070	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C91_14075	COG1131	(ABC) transporter
C1C91_14090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_14100	COG0765	amino acid transport
C1C91_14105	COG1126	abc transporter atp-binding protein
C1C91_14115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1C91_14120	COG0678	peroxiredoxin activity
C1C91_14130	COG0019	diaminopimelate decarboxylase activity
C1C91_14140	COG0095	Lipoate-protein ligase
C1C91_14145	COG2233	PERMEase
C1C91_14150	COG3706	GGDEF domain
C1C91_14150	COG0745	RESPONSE REGULATOR receiver
C1C91_14165	COG2207	Transcriptional regulator
C1C91_14170	COG0281	malic enzyme
C1C91_14200	COG0733	neurotransmitter:sodium symporter activity
C1C91_14205	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1C91_14210	COG3706	GGDEF domain
C1C91_14225	COG1032	radical SAM domain protein
C1C91_14255	COG0673	inositol 2-dehydrogenase activity
C1C91_14260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1C91_14270	COG0739	heme binding
C1C91_14270	COG0741	lytic transglycosylase activity
C1C91_14270	COG1196	nuclear chromosome segregation
C1C91_14295	COG0788	formyltetrahydrofolate deformylase activity
C1C91_14300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C91_14310	COG3118	belongs to the thioredoxin family
C1C91_14320	COG0791	NLP P60 protein
C1C91_14325	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1C91_14340	COG1376	ErfK ybiS ycfS ynhG family protein
C1C91_14340	COG1388	LysM domain
C1C91_14375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_14375	COG2205	protein histidine kinase activity
C1C91_14380	COG3384	dioxygenase
C1C91_14390	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1C91_14400	COG0531	amino acid
C1C91_14405	COG0531	amino acid
C1C91_14420	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_14425	COG1396	sequence-specific DNA binding
C1C91_14425	COG1917	Cupin 2, conserved barrel domain protein
C1C91_14430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C91_14470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1C91_14470	COG4651	solute:proton antiporter activity
C1C91_14485	COG2974	May be involved in recombination
C1C91_14490	COG1247	-acetyltransferase
C1C91_14495	COG0420	3'-5' exonuclease activity
C1C91_14505	COG3038	cytochrome b561
C1C91_14510	COG2190	(PTS) system
C1C91_14520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_14525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1C91_14530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1C91_14545	COG1720	tRNA m6t6A37 methyltransferase activity
C1C91_14565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1C91_14570	COG4988	ABC transporter
C1C91_14585	COG0745	RESPONSE REGULATOR receiver
C1C91_14595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C91_14610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1C91_14615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1C91_14630	COG0083	homoserine kinase activity
C1C91_14635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C91_14670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1C91_14680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1C91_14695	COG3220	belongs to the UPF0276 family
C1C91_14725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C91_14730	COG1289	transmembrane transporter activity
C1C91_14735	COG1763	Mo-molybdopterin cofactor biosynthetic process
C1C91_14740	COG0746	molybdenum cofactor guanylyltransferase activity
C1C91_14745	COG0281	malic enzyme
C1C91_14765	COG2706	6-phosphogluconolactonase activity
C1C91_14775	COG1196	nuclear chromosome segregation
C1C91_14775	COG3264	Mechanosensitive ion channel
C1C91_14785	COG2850	peptidyl-arginine hydroxylation
C1C91_14790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1C91_14795	COG2915	High frequency lysogenization protein hflD homolog
C1C91_14800	COG0482	sulfurtransferase activity
C1C91_14810	COG1187	pseudouridine synthase activity
C1C91_14815	COG0456	acetyltransferase
C1C91_14845	COG0538	isocitrate dehydrogenase activity
C1C91_14855	COG3048	D-serine ammonia-lyase activity
C1C91_14860	COG0583	DNA-binding transcription factor activity
C1C91_14865	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C91_14875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C91_14880	COG2375	cellular response to nickel ion
C1C91_14885	COG1538	Outer membrane efflux protein
C1C91_14890	COG1136	(ABC) transporter
C1C91_14890	COG0577	efflux transmembrane transporter activity
C1C91_14895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_14905	COG0497	DNA recombination
C1C91_14910	COG3706	GGDEF domain
C1C91_14915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1C91_14920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1C91_14925	COG0443	Heat shock 70 kDa protein
C1C91_14930	COG0484	heat shock protein binding
C1C91_14960	COG1285	pathogenesis
C1C91_14970	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C91_14980	COG0640	Transcriptional regulator
C1C91_14990	COG2391	methyltransferase activity
C1C91_15010	COG0095	Lipoate-protein ligase
C1C91_15025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C91_15030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_15040	COG0708	Exodeoxyribonuclease III
C1C91_15065	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C1C91_15080	COG1846	Transcriptional regulator
C1C91_15100	COG0583	DNA-binding transcription factor activity
C1C91_15105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C91_15110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C91_15115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1C91_15120	COG1845	cytochrome c oxidase, subunit III
C1C91_15125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1C91_15130	COG0109	protoheme IX farnesyltransferase activity
C1C91_15135	COG2814	Major facilitator Superfamily
C1C91_15140	COG5507	3-demethylubiquinone-9 3-methyltransferase
C1C91_15155	COG0583	DNA-binding transcription factor activity
C1C91_15175	COG3550	peptidyl-serine autophosphorylation
C1C91_15180	COG1396	sequence-specific DNA binding
C1C91_15190	COG0133	tryptophan synthase activity
C1C91_15195	COG0134	indole-3-glycerol-phosphate synthase activity
C1C91_15195	COG0135	phosphoribosylanthranilate isomerase activity
C1C91_15200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C91_15205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C91_15205	COG0512	Glutamine amidotransferase of anthranilate synthase
C1C91_15210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1C91_15215	COG0613	PHP domain protein
C1C91_15220	COG0009	L-threonylcarbamoyladenylate synthase
C1C91_15230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1C91_15245	COG1946	Acyl-CoA thioesterase
C1C91_15260	COG1309	transcriptional regulator
C1C91_15265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C91_15270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C91_15275	COG1538	Outer membrane efflux protein
C1C91_15355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C91_15370	COG0583	DNA-binding transcription factor activity
C1C91_15385	COG4584	PFAM Integrase catalytic
C1C91_15390	COG1484	DNA-dependent DNA replication
C1C91_15405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1C91_15420	COG1960	acyl-CoA dehydrogenase activity
C1C91_15435	COG0469	pyruvate kinase activity
C1C91_15440	COG1737	Transcriptional regulator
C1C91_15455	COG0745	RESPONSE REGULATOR receiver
C1C91_15465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1C91_15500	COG0438	transferase activity, transferring glycosyl groups
C1C91_15510	COG0297	glycogen (starch) synthase activity
C1C91_15525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1C91_15575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1C91_15580	COG3206	protein involved in exopolysaccharide biosynthesis
C1C91_15580	COG0489	protein tyrosine kinase activity
C1C91_15600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C91_15610	COG3132	Protein of unknown function, DUF480
C1C91_15635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1C91_15650	COG0675	Transposase, IS605 OrfB family
C1C91_15660	COG1278	Cold shock
C1C91_15700	COG0697	spore germination
C1C91_15710	COG0675	Transposase, IS605 OrfB family
C1C91_15715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C91_15720	COG1187	pseudouridine synthase activity
C1C91_15730	COG4166	transmembrane transport
C1C91_15745	COG0622	Phosphoesterase
C1C91_15760	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1C91_15765	COG0835	chemotaxis
C1C91_15765	COG0784	Response regulator, receiver
C1C91_15770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1C91_15775	COG1815	bacterial-type flagellum-dependent cell motility
C1C91_15780	COG1558	bacterial-type flagellum-dependent cell motility
C1C91_15790	COG4786	Flagellar basal body rod
C1C91_15800	COG4786	Flagellar basal body rod
C1C91_15805	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1C91_15810	COG1706	bacterial-type flagellum-dependent cell motility
C1C91_15815	COG3951	Flagellar rod assembly protein muramidase FlgJ
C1C91_15815	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1C91_15860	COG0675	Transposase, IS605 OrfB family
C1C91_15870	COG0248	Ppx GppA phosphatase
C1C91_15875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1C91_15880	COG2716	regulation of RNA biosynthetic process
C1C91_15890	COG2204	response regulator
C1C91_15895	COG3852	Histidine kinase
C1C91_15900	COG2204	response regulator
C1C91_15905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1C91_15915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1C91_15920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1C91_15940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1C91_15950	COG0590	tRNA wobble adenosine to inosine editing
C1C91_15955	COG0573	inorganic phosphate transmembrane transporter activity
C1C91_15960	COG0581	inorganic phosphate transmembrane transporter activity
C1C91_15970	COG0704	Plays a role in the regulation of phosphate uptake
C1C91_15975	COG1253	flavin adenine dinucleotide binding
C1C91_15990	COG0531	amino acid
C1C91_16000	COG1126	abc transporter atp-binding protein
C1C91_16005	COG0765	amino acid transport
C1C91_16010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C91_16020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C91_16040	COG1785	Belongs to the alkaline phosphatase family
C1C91_16045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1C91_16050	COG0477	Major facilitator Superfamily
C1C91_16055	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1C91_16065	COG1199	ATP-dependent helicase activity
C1C91_16080	COG1448	Aminotransferase
C1C91_16105	COG1132	(ABC) transporter
C1C91_16110	COG1663	tetraacyldisaccharide 4'-kinase activity
C1C91_16115	COG2835	tetraacyldisaccharide 4'-kinase activity
C1C91_16125	COG2197	response regulator
C1C91_16155	COG0582	viral genome integration into host DNA
C1C91_16205	COG3039	Transposase
C1C91_16220	COG0604	alcohol dehydrogenase
C1C91_16230	COG2261	transglycosylase associated protein
C1C91_16235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C91_16245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C91_16300	COG2119	membrane
C1C91_16305	COG0023	Translation Initiation Factor
C1C91_16315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1C91_16340	COG4139	cobalamin transport
C1C91_16345	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1C91_16350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C91_16355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1C91_16360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C91_16370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1C91_16380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1C91_16385	COG0505	Belongs to the CarA family
C1C91_16390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1C91_16405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C91_16440	COG0513	Belongs to the DEAD box helicase family
C1C91_16450	COG4104	PAAR repeat-containing protein
C1C91_16470	COG0493	'glutamate synthase
C1C91_16475	COG0067	glutamate synthase
C1C91_16475	COG0069	glutamate synthase activity
C1C91_16475	COG0070	glutamate synthase
C1C91_16480	COG1242	4 iron, 4 sulfur cluster binding
C1C91_16530	COG1113	amino acid transport
C1C91_16540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1C91_16545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1C91_16545	COG0574	Belongs to the PEP-utilizing enzyme family
C1C91_16550	COG1119	ATPase activity
C1C91_16580	COG1464	Belongs to the NlpA lipoprotein family
C1C91_16590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C91_16595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C91_16605	COG0101	tRNA pseudouridine synthase activity
C1C91_16610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1C91_16615	COG0285	dihydrofolate synthase activity
C1C91_16620	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1C91_16625	COG2920	part of a sulfur-relay system
C1C91_16630	COG1289	transmembrane transporter activity
C1C91_16635	COG0670	Belongs to the BI1 family
C1C91_16675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1C91_16685	COG5001	Diguanylate cyclase
C1C91_16690	COG0564	pseudouridine synthase activity
C1C91_16705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1C91_16715	COG0625	glutathione transferase activity
C1C91_16730	COG0367	asparagine synthase
C1C91_16740	COG0647	UMP catabolic process
C1C91_16745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C91_16755	COG1902	pentaerythritol trinitrate reductase activity
C1C91_16760	COG1253	flavin adenine dinucleotide binding
C1C91_16775	COG3039	Transposase
C1C91_16785	COG0277	FAD linked oxidase domain protein
C1C91_16785	COG0247	lactate metabolic process
C1C91_16795	COG2050	protein possibly involved in aromatic compounds catabolism
C1C91_16810	COG5001	Diguanylate cyclase
C1C91_16815	COG0583	DNA-binding transcription factor activity
C1C91_16820	COG2814	Major facilitator Superfamily
C1C91_16825	COG2056	Na+-H+ antiporter family
C1C91_16830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C91_16845	COG0483	inositol monophosphate 1-phosphatase activity
C1C91_16855	COG0625	glutathione transferase activity
C1C91_16860	COG0625	glutathione transferase activity
C1C91_16870	COG0601	transmembrane transport
C1C91_16875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C91_16880	COG0444	Belongs to the ABC transporter superfamily
C1C91_16885	COG2814	Major facilitator Superfamily
C1C91_16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C91_16910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C91_16930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_16935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1C91_16940	COG0509	glycine decarboxylation via glycine cleavage system
C1C91_16945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C91_16945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C91_16965	COG2814	Major facilitator Superfamily
C1C91_16970	COG3634	alkyl hydroperoxide reductase activity
C1C91_16975	COG0450	alkyl hydroperoxide reductase
C1C91_16980	COG0517	IMP dehydrogenase activity
C1C91_16985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1C91_16990	COG0343	queuine tRNA-ribosyltransferase activity
C1C91_16995	COG1862	Preprotein translocase
C1C91_17000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C91_17005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C91_17010	COG2897	thiosulfate sulfurtransferase activity
C1C91_17045	COG1104	cysteine desulfurase activity
C1C91_17050	COG0822	iron-sulfur transferase activity
C1C91_17060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C91_17065	COG0443	Heat shock 70 kDa protein
C1C91_17070	COG0633	Ferredoxin
C1C91_17085	COG0105	UTP biosynthetic process
C1C91_17090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1C91_17100	COG1426	Protein conserved in bacteria
C1C91_17110	COG0124	histidyl-tRNA synthetase
C1C91_17115	COG2976	Protein conserved in bacteria
C1C91_17120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C91_17125	COG1160	GTP binding
C1C91_17130	COG1645	bacterial-type flagellum-dependent swarming motility
C1C91_17135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C91_17140	COG0047	phosphoribosylformylglycinamidine synthase activity
C1C91_17140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1C91_17145	COG1007	ATP synthesis coupled electron transport
C1C91_17150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C91_17160	COG0713	ATP synthesis coupled electron transport
C1C91_17165	COG0839	Belongs to the complex I subunit 6 family
C1C91_17170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C91_17175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1C91_17195	COG0649	NAD binding
C1C91_17195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C91_17200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C91_17205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C91_17210	COG1360	Flagellar Motor Protein
C1C91_17215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C91_17240	COG4245	von Willebrand factor, type A
C1C91_17265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1C91_17320	COG4974	Belongs to the 'phage' integrase family
C1C91_17330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1C91_17340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C91_17345	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_17350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C91_17385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1C91_17405	COG0724	RNA recognition motif
C1C91_17410	COG4989	oxidoreductase activity
C1C91_17435	COG0745	RESPONSE REGULATOR receiver
C1C91_17450	COG5001	Diguanylate cyclase
C1C91_17450	COG3300	MHYT domain
C1C91_17455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1C91_17485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C91_17490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1C91_17495	COG0539	negative regulation of cytoplasmic translation
C1C91_17500	COG0776	regulation of translation
C1C91_17510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1C91_17530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1C91_17535	COG0602	queuosine metabolic process
C1C91_17540	COG3530	Putative quorum-sensing-regulated virulence factor
C1C91_17545	COG2096	Adenosyltransferase
C1C91_17550	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C91_17555	COG1757	Na H antiporter
C1C91_17560	COG1435	thymidine kinase activity
C1C91_17595	COG2723	6-phospho-beta-galactosidase activity
C1C91_17610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1C91_17625	COG3550	peptidyl-serine autophosphorylation
C1C91_17655	COG2801	Transposase and inactivated derivatives
C1C91_17685	COG3039	Transposase
C1C91_17745	COG3039	Transposase
C1C91_17775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_17865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1C91_17880	COG2910	NAD(P)H-binding
C1C91_17885	COG0583	DNA-binding transcription factor activity
C1C91_17890	COG4977	sequence-specific DNA binding
C1C91_17890	COG1917	Cupin 2, conserved barrel domain protein
C1C91_17895	COG2200	EAL domain
C1C91_17900	COG2203	Gaf domain
C1C91_17900	COG4251	negative regulation of phosphorylation
C1C91_17900	COG5001	Diguanylate cyclase
C1C91_17900	COG3706	GGDEF domain
C1C91_17910	COG3706	GGDEF domain
C1C91_17925	COG4774	siderophore transport
C1C91_17935	COG0583	DNA-binding transcription factor activity
C1C91_17940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C91_17950	COG0517	IMP dehydrogenase activity
C1C91_17950	COG0516	GMP reductase activity
C1C91_17960	COG3046	protein related to deoxyribodipyrimidine photolyase
C1C91_17980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C91_17985	COG1138	Cytochrome C-type biogenesis protein
C1C91_17990	COG3301	Polysulphide reductase, NrfD
C1C91_17995	COG0437	4 iron, 4 sulfur cluster binding
C1C91_18000	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1C91_18015	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1C91_18025	COG3012	SEC-C Motif Domain Protein
C1C91_18035	COG1940	carbohydrate kinase activity
C1C91_18035	COG1846	Transcriptional regulator
C1C91_18045	COG4565	transcriptional regulatory protein
C1C91_18060	COG3181	Tripartite tricarboxylate transporter family receptor
C1C91_18065	COG1196	nuclear chromosome segregation
C1C91_18065	COG0741	lytic transglycosylase activity
C1C91_18065	COG0739	heme binding
C1C91_18070	COG2985	domain, Protein
C1C91_18070	COG0569	domain protein
C1C91_18085	COG0556	nucleotide-excision repair
C1C91_18095	COG0586	Pfam SNARE associated Golgi protein
C1C91_18100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1C91_18105	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C91_18110	COG2186	Transcriptional regulator
C1C91_18115	COG2719	SpoVR family
C1C91_18120	COG2718	Belongs to the UPF0229 family
C1C91_18125	COG2766	serine protein kinase
C1C91_18130	COG0514	ATP-dependent DNA helicase (RecQ)
C1C91_18140	COG0814	amino acid
C1C91_18170	COG0058	SHG alpha-glucan phosphorylase activity
C1C91_18190	COG3118	belongs to the thioredoxin family
C1C91_18200	COG1132	(ABC) transporter
C1C91_18205	COG1132	(ABC) transporter
C1C91_18220	COG2501	S4 domain
C1C91_18230	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1C91_18250	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1C91_18280	COG1742	UPF0060 membrane protein
C1C91_18295	COG0513	Belongs to the DEAD box helicase family
C1C91_18300	COG0386	Belongs to the glutathione peroxidase family
C1C91_18310	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1C91_18325	COG0583	DNA-binding transcription factor activity
C1C91_18340	COG3593	DNA synthesis involved in DNA repair
C1C91_18385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C91_18390	COG1011	Hydrolase
C1C91_18395	COG1473	amidohydrolase
C1C91_18420	COG0205	6-phosphofructokinase activity
C1C91_18430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1C91_18435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C91_18445	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1C91_18450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1C91_18490	COG0675	Transposase, IS605 OrfB family
C1C91_18520	COG2824	Alkylphosphonate utilization operon protein PhnA
C1C91_18555	COG2840	Smr protein MutS2
C1C91_18560	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C91_18565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1C91_18575	COG0513	Belongs to the DEAD box helicase family
C1C91_18580	COG5654	RES domain protein
C1C91_18590	COG0814	amino acid
C1C91_18595	COG1609	Transcriptional regulator
C1C91_18600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_18600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C91_18605	COG1105	Belongs to the carbohydrate kinase PfkB family
C1C91_18610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C91_18610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1C91_18610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C91_18615	COG3313	Fe-S protein
C1C91_18620	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1C91_18625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C91_18630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C91_18635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C91_18670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1C91_18675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1C91_18680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1C91_18685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1C91_18690	COG3039	Transposase
C1C91_18700	COG4974	Belongs to the 'phage' integrase family
C1C91_18705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1C91_18710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C91_18710	COG0072	phenylalanine-tRNA ligase activity
C1C91_18715	COG0776	regulation of translation
C1C91_18735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1C91_18750	COG0675	Transposase, IS605 OrfB family
C1C91_18760	COG1609	Transcriptional regulator
C1C91_18765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C91_18770	COG1879	ABC-type sugar transport system periplasmic component
C1C91_18775	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C91_18780	COG1129	ABC transporter
C1C91_18785	COG1869	D-ribose catabolic process
C1C91_18790	COG0625	glutathione transferase activity
C1C91_18800	COG0675	Transposase, IS605 OrfB family
C1C91_18815	COG0037	tRNA processing
C1C91_18820	COG0589	response to stress
C1C91_18825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C91_18840	COG2217	Heavy metal translocating P-type atpase
C1C91_18850	COG2010	Cytochrome c
C1C91_18865	COG3278	Belongs to the heme-copper respiratory oxidase family
C1C91_18875	COG1956	GAF domain-containing protein
C1C91_18880	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1C91_18890	COG0308	aminopeptidase N
C1C91_18900	COG2902	Dehydrogenase
C1C91_18905	COG0167	dihydroorotate dehydrogenase activity
C1C91_18915	COG0116	Belongs to the methyltransferase superfamily
C1C91_18915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C91_18940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C91_18945	COG1067	ATP-dependent peptidase activity
C1C91_18955	COG3141	response to X-ray
C1C91_18970	COG2995	paraquat-inducible protein a
C1C91_18980	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1C91_18980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C91_18995	COG0084	hydrolase, TatD family'
C1C91_19000	COG0470	DNA polymerase III
C1C91_19005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1C91_19010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1C91_19015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1C91_19020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C91_19025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1C91_19030	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_19040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1C91_19045	COG0416	fatty acid biosynthetic process
C1C91_19050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1C91_19055	COG1399	metal-binding, possibly nucleic acid-binding protein
C1C91_19070	COG0564	pseudouridine synthase activity
C1C91_19075	COG1530	ribonuclease E activity
C1C91_19080	COG0306	phosphate transporter
C1C91_19085	COG0717	Belongs to the dCTP deaminase family
C1C91_19090	COG0572	uridine kinase
C1C91_19095	COG0489	protein tyrosine kinase activity
C1C91_19100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C91_19100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C91_19110	COG1254	Belongs to the acylphosphatase family
C1C91_19115	COG0840	transmembrane signaling receptor activity
C1C91_19120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C91_19135	COG0709	Synthesizes selenophosphate from selenide and ATP
C1C91_19140	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1C91_19145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C91_19160	COG0675	Transposase, IS605 OrfB family
C1C91_19175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1C91_19185	COG1643	Atp-dependent helicase
C1C91_19195	COG2197	response regulator
C1C91_19210	COG0583	DNA-binding transcription factor activity
C1C91_19215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1C91_19225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1C91_19230	COG2832	Protein of unknown function (DUF454)
C1C91_19235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C91_19260	COG0318	PFAM AMP-dependent synthetase and ligase
C1C91_19275	COG1214	PFAM Peptidase M22, glycoprotease
C1C91_19290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1C91_19295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1C91_19300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1C91_19305	COG0131	Imidazoleglycerol-phosphate dehydratase
C1C91_19305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C91_19310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1C91_19315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1C91_19320	COG3437	response regulator, receiver
C1C91_19330	COG2205	protein histidine kinase activity
C1C91_19330	COG2198	Histidine kinase
C1C91_19330	COG0784	Response regulator, receiver
C1C91_19335	COG0107	imidazoleglycerol-phosphate synthase activity
C1C91_19340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1C91_19340	COG0140	phosphoribosyl-ATP diphosphatase activity
C1C91_19350	COG2378	regulation of single-species biofilm formation
C1C91_19355	COG0318	PFAM AMP-dependent synthetase and ligase
C1C91_19360	COG3134	Outer membrane lipoprotein
C1C91_19405	COG4681	YaeQ
C1C91_19420	COG0183	Belongs to the thiolase family
C1C91_19425	COG0714	Associated with various cellular activities
C1C91_19465	COG2067	long-chain fatty acid transport protein
C1C91_19470	COG2067	long-chain fatty acid transport protein
C1C91_19475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1C91_19490	COG1301	dicarboxylic acid transport
C1C91_19495	COG3123	guanosine phosphorylase activity
C1C91_19500	COG1760	l-serine dehydratase
C1C91_19510	COG1760	l-serine dehydratase
C1C91_19525	COG3100	YcgL domain-containing protein
C1C91_19530	COG0850	regulation of cytokinetic process
C1C91_19535	COG2894	cell division
C1C91_19550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C91_19595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1C91_19600	COG0697	spore germination
C1C91_19605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1C91_19610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C91_19625	COG0307	riboflavin synthase, alpha
C1C91_19635	COG0534	Mate efflux family protein
C1C91_19665	COG0417	DNA replication proofreading
C1C91_19680	COG1560	Kdo2-lipid A biosynthetic process
C1C91_19685	COG1560	Kdo2-lipid A biosynthetic process
C1C91_19695	COG0583	DNA-binding transcription factor activity
C1C91_19700	COG0673	inositol 2-dehydrogenase activity
C1C91_19705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1C91_19720	COG0583	DNA-binding transcription factor activity
C1C91_19730	COG2723	6-phospho-beta-galactosidase activity
C1C91_19735	COG0583	DNA-binding transcription factor activity
C1C91_19740	COG0745	RESPONSE REGULATOR receiver
C1C91_19740	COG3706	GGDEF domain
C1C91_19745	COG0243	molybdopterin cofactor binding
C1C91_19750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1C91_19760	COG1879	ABC-type sugar transport system periplasmic component
C1C91_19765	COG1129	ABC transporter
C1C91_19775	COG0784	Response regulator, receiver
C1C91_19775	COG2205	protein histidine kinase activity
C1C91_19780	COG2197	response regulator
C1C91_19785	COG1012	belongs to the aldehyde dehydrogenase family
C1C91_19790	COG0531	amino acid
C1C91_19815	COG2072	flavoprotein involved in K transport
C1C91_19820	COG0583	DNA-binding transcription factor activity
C1C91_19850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1C91_19860	COG2003	Belongs to the UPF0758 family
C1C91_19875	COG1484	DNA-dependent DNA replication
C1C91_19880	COG4584	PFAM Integrase catalytic
C1C91_19905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_19925	COG0582	viral genome integration into host DNA
C1C91_19935	COG0730	response to heat
C1C91_19945	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_19955	COG1024	Enoyl-CoA hydratase
C1C91_19960	COG1024	Enoyl-CoA hydratase
C1C91_19975	COG1960	acyl-CoA dehydrogenase activity
C1C91_19980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1C91_19985	COG1024	Enoyl-CoA hydratase
C1C91_20010	COG1584	GPR1 FUN34 yaaH family protein
C1C91_20015	COG3228	Belongs to the MtfA family
C1C91_20025	COG1115	amino acid carrier protein
C1C91_20030	COG1024	Enoyl-CoA hydratase
C1C91_20045	COG3162	membrane
C1C91_20050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C91_20055	COG0488	(ABC) transporter
C1C91_20060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C91_20065	COG0776	regulation of translation
C1C91_20070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1C91_20075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1C91_20080	COG0740	serine-type endopeptidase activity
C1C91_20085	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1C91_20100	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1C91_20105	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C91_20110	COG1136	(ABC) transporter
C1C91_20115	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C91_20125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1C91_20130	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1C91_20140	COG0697	spore germination
C1C91_20150	COG2062	phosphohistidine phosphatase, SixA
C1C91_20170	COG1846	Transcriptional regulator
C1C91_20195	COG1484	DNA-dependent DNA replication
C1C91_20200	COG4584	PFAM Integrase catalytic
C1C91_20310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1C91_20350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1C91_20400	COG0789	Transcriptional regulator
C1C91_20485	COG0582	viral genome integration into host DNA
C1C91_20495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C91_20495	COG0519	Catalyzes the synthesis of GMP from XMP
C1C91_20500	COG0517	IMP dehydrogenase activity
C1C91_20500	COG0516	GMP reductase activity
C1C91_20515	COG0675	Transposase, IS605 OrfB family
C1C91_20545	COG2885	chlorophyll binding
C1C91_20565	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1C91_20575	COG3768	UPF0283 membrane protein
C1C91_20580	COG3106	COG3106 Predicted ATPase
C1C91_20595	COG1842	Phage shock protein A
C1C91_20600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1C91_20610	COG4168	peptide transport system, permease
C1C91_20615	COG4171	peptide transport system, permease
C1C91_20625	COG4172	Belongs to the ABC transporter superfamily
C1C91_20640	COG0675	Transposase, IS605 OrfB family
C1C91_20655	COG1263	PTS System
C1C91_20655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_20665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1C91_20670	COG1286	toxin biosynthetic process
C1C91_20675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1C91_20680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1C91_20685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1C91_20690	COG0531	amino acid
C1C91_20690	COG1674	ftsk spoiiie
C1C91_20700	COG0686	Belongs to the AlaDH PNT family
C1C91_20705	COG0492	ferredoxin-NADP+ reductase activity
C1C91_20715	COG3706	GGDEF domain
C1C91_20720	COG3134	Outer membrane lipoprotein
C1C91_20725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1C91_20730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1C91_20735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1C91_20740	COG0542	response to heat
C1C91_20745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1C91_20750	COG1278	Cold shock
C1C91_20755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C91_20760	COG2076	Multidrug Resistance protein
C1C91_20770	COG1944	ATP diphosphatase activity
C1C91_20775	COG2116	formate transmembrane transporter activity
C1C91_20780	COG1882	Formate acetyltransferase
C1C91_20795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1C91_20800	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C91_20805	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C91_20810	COG0567	Dehydrogenase, E1 component
C1C91_20825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1C91_20830	COG2009	succinate dehydrogenase
C1C91_20850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C91_20855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C91_20855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1C91_20865	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C91_20880	COG1451	nucleotide metabolic process
C1C91_20895	COG0254	rRNA binding
C1C91_20900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C91_20925	COG1879	ABC-type sugar transport system periplasmic component
C1C91_20930	COG1069	ribulokinase activity
C1C91_20940	COG2160	L-arabinose isomerase activity
C1C91_20950	COG0436	Aminotransferase
C1C91_20955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C91_20970	COG0392	lysyltransferase activity
C1C91_20970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1C91_20975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1C91_21000	COG0469	pyruvate kinase activity
C1C91_21010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C91_21010	COG1263	PTS System
C1C91_21020	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C1C91_21025	COG3833	ABC-type maltose transport systems, permease component
C1C91_21030	COG1175	transmembrane transport
C1C91_21035	COG2182	Extracellular solute-binding protein
C1C91_21080	COG4580	involved in the transport of maltose and maltodextrins
C1C91_21085	COG1609	Transcriptional regulator
C1C91_21090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C91_21095	COG1085	galactose-1-phosphate uridylyltransferase
C1C91_21110	COG5433	transposase activity
C1C91_21130	COG0300	oxidoreductase activity
C1C91_21165	COG2925	Exonuclease
C1C91_21175	COG3385	transposase activity
C1C91_21185	COG1380	Effector of murein hydrolase LrgA
C1C91_21190	COG1346	cytolysis
C1C91_21200	COG0295	cytidine deaminase activity
C1C91_21205	COG1022	Amp-dependent synthetase and ligase
C1C91_21220	COG0861	Integral membrane protein TerC family
C1C91_21225	COG3385	transposase activity
C1C91_21230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C91_21235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1C91_21240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1C91_21280	COG4771	TonB-dependent receptor
C1C91_21285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C91_21290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C91_21295	COG1120	ATPase activity
C1C91_21310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C91_21320	COG1028	Short-chain dehydrogenase reductase Sdr
C1C91_21325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C91_21330	COG1535	isochorismatase
C1C91_21330	COG3433	isochorismatase activity
C1C91_21370	COG3300	MHYT domain
C1C91_21370	COG5001	Diguanylate cyclase
C1C91_21385	COG0840	transmembrane signaling receptor activity
C1C91_21390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C91_21395	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C1C91_21405	COG0563	adenylate kinase activity
C1C91_21410	COG0326	Molecular chaperone. Has ATPase activity
C1C91_21415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1C91_21450	COG0659	secondary active sulfate transmembrane transporter activity
C1C91_21470	COG0675	Transposase, IS605 OrfB family
C1C91_21510	COG0672	)-iron permease
C1C91_21535	COG2814	Major facilitator Superfamily
C1C91_21555	COG1136	(ABC) transporter
C1C91_21595	COG1139	Iron-sulfur cluster binding protein
C1C91_21600	COG0247	lactate metabolic process
C1C91_21605	COG1620	l-lactate permease
C1C91_21635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1C91_21640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C91_21640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1C91_21645	COG0527	aspartate kinase activity
C1C91_21660	COG0393	Putative heavy-metal-binding
C1C91_21665	COG1252	NADH dehydrogenase
C1C91_21700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C91_21740	COG0537	adenosine 5'-monophosphoramidase activity
C1C91_21755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C91_21775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1C91_21795	COG1301	dicarboxylic acid transport
C1C91_21805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C91_21810	COG0861	Integral membrane protein TerC family
C1C91_21820	COG0444	Belongs to the ABC transporter superfamily