locus-tag class description FCM34_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FCM34_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FCM34_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FCM34_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FCM34_00030 ENOG4105D29 Helix-turn-helix type 11 domain protein FCM34_00035 ENOG4108ZNX Heat shock protein FCM34_00040 ENOG4108ZNX Heat shock protein FCM34_00045 ENOG4105JKW Valine--pyruvate aminotransferase FCM34_00060 ENOG4105C2C drug resistance transporter, Bcr CflA FCM34_00065 ENOG4105EEX Two component transcriptional regulator (Winged helix family FCM34_00070 ENOG4105C08 Histidine kinase FCM34_00080 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FCM34_00085 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FCM34_00095 ENOG4105F2I Transposase FCM34_00125 ENOG4105CVR type I restriction-modification system FCM34_00150 ENOG4105DC8 reductase FCM34_00155 ENOG4105BZU Histidine kinase FCM34_00160 ENOG4105BZS acriflavin resistance protein FCM34_00165 ENOG410624X efflux transporter, rnd family, mfp subunit FCM34_00170 ENOG4105Y7M Transcriptional regulator, TetR family FCM34_00200 ENOG4105DQF Hydrolase FCM34_00205 ENOG4108EUD Lysophospholipase FCM34_00210 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FCM34_00215 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FCM34_00220 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FCM34_00235 ENOG4105DKP glycosyl transferase, family 9 FCM34_00240 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) FCM34_00250 ENOG4105EMK carboxylate amino acid amine transporter FCM34_00280 ENOG4108M6U Universal stress protein A FCM34_00285 ENOG4105RKW reductase (By FCM34_00290 ENOG4105BZU Histidine kinase FCM34_00295 ENOG41090A1 ferritin FCM34_00300 ENOG4105CBX hi0933 family FCM34_00305 ENOG4105EU0 Major facilitator Superfamily FCM34_00310 ENOG4108NIW Leucine export protein LeuE FCM34_00330 ENOG4105F2I Transposase FCM34_00345 ENOG4108HRK Histidine kinase FCM34_00350 ENOG4105DY9 regulatoR FCM34_00355 ENOG4105FCD Major Facilitator FCM34_00365 ENOG4105EQR Transposase IS116 IS110 IS902 FCM34_00370 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FCM34_00375 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FCM34_00380 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FCM34_00420 ENOG4105CD5 CoA-binding domain protein FCM34_00430 ENOG4105EMY transcriptional regulator FCM34_00435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FCM34_00440 ENOG4107QP8 phosphohexose isomerase FCM34_00450 ENOG4105D64 Mechanosensitive ion channel FCM34_00460 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FCM34_00465 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FCM34_00470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FCM34_00475 ENOG4105W5Q DNA repair protein (RadC FCM34_00480 ENOG4105KDC 50s ribosomal protein l28 FCM34_00485 ENOG4105W0E 50S ribosomal protein L33 FCM34_00495 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FCM34_00500 ENOG4108MJ5 VirK protein FCM34_00505 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FCM34_00510 ENOG4105M5K heptosyltransferase FCM34_00515 ENOG4106WTF Glycosyl transferase, family 2 FCM34_00520 ENOG4105XA0 heptosyltransferase ii FCM34_00525 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FCM34_00535 ENOG4105DSJ YicC domain protein FCM34_00540 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FCM34_00545 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FCM34_00565 ENOG4105PC1 Conserved Protein FCM34_00575 ENOG4105E27 serine threonine protein kinase FCM34_00580 ENOG4108Z33 Thiol disulfide Interchange Protein FCM34_00585 ENOG4105S7S phosphonate abc transporter FCM34_00590 ENOG4108VA1 ABC transporter FCM34_00595 ENOG4105EHI Phosphonate ABC transporter, periplasmic FCM34_00605 ENOG4108RWI nicotinamidase FCM34_00620 ENOG4105EWC Purine nucleoside phosphorylase FCM34_00625 ENOG4106HNH Acyl-transferase FCM34_00630 ENOG4106HNH Acyl-transferase FCM34_00635 ENOG4105C0P Mg chelatase subunit ChlI FCM34_00650 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FCM34_00655 ENOG4105CM2 brancheD-chain amino acid aminotransferase FCM34_00660 ENOG4105C01 Dihydroxy-acid dehydratase FCM34_00665 ENOG4105C7B Threonine dehydratase FCM34_00670 ENOG4105UYK outer membrane protein a FCM34_00680 ENOG4105XEA Tetr family transcriptional regulator FCM34_00685 ENOG4105C25 Primosomal protein n' FCM34_00690 ENOG4105VFB Binds the 23S rRNA (By similarity) FCM34_00695 ENOG4105CGD Nad-dependent epimerase dehydratase FCM34_00700 ENOG4105C6K Malic enzyme FCM34_00710 ENOG4105JJR Histidine kinase FCM34_00725 ENOG4107EXC regulatoR FCM34_00730 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FCM34_00745 ENOG4107R28 alpha amylase, catalytic region FCM34_00760 ENOG4105R8A Heat shock protein FCM34_00765 ENOG4105C5I Dehydrogenase FCM34_00770 ENOG4108RH0 Crea protein FCM34_00785 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FCM34_00790 ENOG4105CFQ glutamine synthetase FCM34_00795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FCM34_00805 ENOG4108HM4 ABC transporter FCM34_00810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FCM34_00815 ENOG4105F38 ABC transporter, permease FCM34_00820 ENOG4105D38 putrescine abc transporter FCM34_00825 ENOG4108RPX mosc domain containing protein FCM34_00840 ENOG4108VUY thioesterase Superfamily protein FCM34_00845 ENOG4105C9U ATP-dependent DNA helicase RecQ FCM34_00850 ENOG4105N7H Cytochrome FCM34_00855 ENOG4105CNG UPF0061 protein FCM34_00865 ENOG4105EX9 Membrane FCM34_00870 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FCM34_00875 ENOG4105CJW magnesium transporter FCM34_00880 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FCM34_00885 ENOG4107V9H nitrite transporter FCM34_00890 ENOG4105WZK nitrite reductase NADPH small subunit FCM34_00895 ENOG4107QZF nitrite reductase NADPH large subunit FCM34_00900 ENOG4107QWP ABC-2 type transporter FCM34_00905 ENOG4107QWP ABC-2 type transporter FCM34_00910 ENOG4105CJ1 ABC, transporter FCM34_00915 ENOG4105D0S secretion protein (HlyD FCM34_00935 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FCM34_00940 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FCM34_00950 ENOG4105C75 arginyL-tRNA synthetase FCM34_00960 ENOG4105K6V RNA polymerase FCM34_00965 ENOG4108NIX Factor ChrR FCM34_00970 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FCM34_00975 ENOG4105CPC Aldo Keto reductase FCM34_00980 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FCM34_00985 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FCM34_00990 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FCM34_00995 ENOG4105CMR udp-glucose 4-epimerase FCM34_01000 ENOG41060NJ transcriptional regulator FCM34_01005 ENOG4105CNT hydrolase family 2 FCM34_01020 ENOG4107SDZ Galactoside transport system permease protein mglC FCM34_01025 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_01035 ENOG4108J1Q FCM34_01045 ENOG4105C5B carbamate kinase FCM34_01050 ENOG4105DBV ornithine carbamoyltransferase FCM34_01055 ENOG4105CSX c4-dicarboxylate anaerobic carrier FCM34_01060 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FCM34_01065 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FCM34_01070 ENOG4105CXT aspartate transcarbamylase FCM34_01095 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_01105 ENOG4105QNF Outer membrane lipoprotein FCM34_01110 ENOG4105CF7 AraC family transcriptional regulator FCM34_01115 ENOG4108I6A alcohol dehydrogenase FCM34_01120 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FCM34_01125 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FCM34_01130 ENOG4105WWK YheO domain protein FCM34_01135 ENOG4105CEM UPF0597 protein FCM34_01140 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FCM34_01145 ENOG4105C34 Pseudouridine synthase FCM34_01150 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FCM34_01155 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FCM34_01165 ENOG4105CU9 asparagine synthetase A FCM34_01170 ENOG4108VVK transcriptional Regulator, AsnC FCM34_01180 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FCM34_01185 ENOG410642E Short chain dehydrogenase FCM34_01200 ENOG4107WP9 Histidine kinase FCM34_01210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_01215 ENOG4108UQ5 membrane protein YcdZ FCM34_01225 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FCM34_01230 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FCM34_01245 ENOG4105XJC Two component transcriptional regulator (Winged helix family FCM34_01250 ENOG4105IFJ Histidine kinase FCM34_01260 ENOG4107QY8 reductase FCM34_01265 ENOG4105CUW cytochrome C-TYPE protein FCM34_01270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FCM34_01280 ENOG4107ZYR domain protein FCM34_01285 ENOG4105D4A Cell wall formation (By similarity) FCM34_01290 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FCM34_01295 ENOG4105CS9 pantothenic acid kinase FCM34_01310 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FCM34_01320 ENOG4105PM1 preprotein translocase subunit SecE FCM34_01325 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FCM34_01330 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FCM34_01335 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FCM34_01340 ENOG4108VZM 50s ribosomal protein L10 FCM34_01345 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FCM34_01350 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FCM34_01355 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FCM34_01360 ENOG4105WWK YheO domain protein FCM34_01365 ENOG4105KME endoribonuclease L-psp FCM34_01370 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FCM34_01380 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FCM34_01385 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FCM34_01390 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FCM34_01395 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FCM34_01400 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FCM34_01405 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FCM34_01440 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FCM34_01445 ENOG4105C7N Xanthine uracil vitamin C permease FCM34_01450 ENOG4105CMT Dihydroxyacetone kinase FCM34_01455 ENOG4108UTZ Dihydroxyacetone kinase FCM34_01470 ENOG4105ETT transcriptional Regulator, LysR family FCM34_01475 ENOG4105DWY Agmatine deiminase FCM34_01490 ENOG4105DWY Agmatine deiminase FCM34_01500 ENOG4105IPI Membrane FCM34_01525 ENOG4105CH6 catalase FCM34_01530 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FCM34_01550 ENOG4105BZU Histidine kinase FCM34_01560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FCM34_01570 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FCM34_01595 ENOG4105CWB LysR family transcriptional Regulator FCM34_01605 ENOG4105C2I pirin domain protein FCM34_01610 ENOG4108VBZ doxx family FCM34_01615 ENOG4105DSY exodeoxyribonuclease V, gamma FCM34_01620 ENOG4107QKA exodeoxyribonuclease V beta FCM34_01625 ENOG4107QYX exodeoxyribonuclease v alpha FCM34_01630 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FCM34_01645 ENOG4108YZA Nitrogen regulatory protein pii FCM34_01650 ENOG4105BZU Histidine kinase FCM34_01660 ENOG4108NVR Methyl-accepting chemotaxis FCM34_01670 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FCM34_01675 ENOG4105E0F Histidine kinase FCM34_01680 ENOG4105VEQ Cold shock protein FCM34_01710 ENOG4108C33 Resolvase FCM34_01715 ENOG4108R0M Aminoglycoside FCM34_01730 ENOG4107W31 Pentapeptide repeat protein FCM34_01795 ENOG4105C5H ABC transporter FCM34_01820 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FCM34_01875 ENOG4105F5W AtP-binding protein FCM34_01880 ENOG4105D70 Integrase catalytic subunit FCM34_01890 ENOG4107QYX exodeoxyribonuclease v alpha FCM34_01915 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FCM34_01920 ENOG4108UUM single-stranded DNA-binding protein FCM34_01925 ENOG41086KC Transcriptional regulator FCM34_01930 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FCM34_01935 ENOG4105EIF outer membrane protein W FCM34_01955 ENOG4105SYT Methylenetetrahydrofolate reductase FCM34_01965 ENOG4105DKK Benzoate FCM34_01970 ENOG4108JCI Transcriptional regulator FCM34_02000 ENOG41090HJ UPF0265 protein FCM34_02010 ENOG4105N42 UPF0307 protein FCM34_02015 ENOG4105CMS peptidase U62, modulator of DNA gyrase FCM34_02020 ENOG410601J HemY protein FCM34_02025 ENOG4105ECF c-methyltransferase FCM34_02030 ENOG41076E6 Uroporphyrinogen-III Synthase FCM34_02035 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FCM34_02040 ENOG4107T0K Adenylate cyclase FCM34_02045 ENOG4106CJB Phospholipase Carboxylesterase FCM34_02050 ENOG4105XQ6 frataxin-like protein FCM34_02060 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FCM34_02065 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FCM34_02075 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FCM34_02080 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FCM34_02090 ENOG4108Z86 Glutamine amidotransferase FCM34_02095 ENOG410667J hydrolase FCM34_02105 ENOG4107K5X Membrane-bound metal-dependent hydrolase FCM34_02110 ENOG4108I62 cina-like protein FCM34_02120 ENOG4105CVG Homoserine O-transsuccinylase FCM34_02130 ENOG4108YXU transcriptional regulator AsnC family FCM34_02135 ENOG4105E0M Sulfatase FCM34_02150 ENOG4105KT7 mgtC SapB transporter FCM34_02170 ENOG4105EMU Dehydrogenase FCM34_02185 ENOG4108I6A alcohol dehydrogenase FCM34_02195 ENOG4108IQK o-acetylhomoserine FCM34_02225 ENOG4107IFA Lipase (EC 3.1.1.3) FCM34_02235 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FCM34_02240 ENOG4108UB4 uncharacterized protein ygjQ FCM34_02245 ENOG4107MM9 BNR Asp-box repeat-containing protein FCM34_02250 ENOG4105CEY Amp-dependent synthetase and ligase FCM34_02255 ENOG4105DNI Converts SHCHC to OSB (By similarity) FCM34_02260 ENOG4108IPT Naphthoate synthase FCM34_02265 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FCM34_02270 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FCM34_02275 ENOG4105E4F Isochorismate synthase FCM34_02280 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FCM34_02300 ENOG4105C1J atp-dependent rna helicase FCM34_02305 ENOG4105F2I Transposase FCM34_02310 ENOG4105D9N nucleoside FCM34_02325 ENOG4108UPT UPF0178 protein FCM34_02345 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FCM34_02350 ENOG4105E61 Mannitol repressor protein FCM34_02355 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FCM34_02360 ENOG4105CTS PTS system mannitol-specific FCM34_02365 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FCM34_02370 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FCM34_02375 ENOG4105NNS Autoinducer synthesis protein FCM34_02380 ENOG4105VJY transcriptional regulator FCM34_02385 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FCM34_02390 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FCM34_02395 ENOG4105D1S lipid A biosynthesis FCM34_02400 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FCM34_02405 ENOG4105DFG type I secretion outer membrane protein FCM34_02410 ENOG41087AY ADP-Ribose pyrophosphatase FCM34_02415 ENOG4108SX3 cytoplasmic protein FCM34_02420 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FCM34_02425 ENOG4105IPS esterase FCM34_02445 ENOG4105Y49 secretion protein, HlyD family FCM34_02450 ENOG4105DSW Fusaric acid resistance protein FCM34_02455 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FCM34_02460 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FCM34_02500 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FCM34_02510 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FCM34_02530 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FCM34_02535 ENOG41087YS Phage shock protein A FCM34_02550 ENOG41082IR Excinuclease ABC C subunit domain protein FCM34_02555 ENOG4105FR1 rard protein FCM34_02560 ENOG4108RG0 uracil-dna glycosylase FCM34_02570 ENOG4105ETT transcriptional Regulator, LysR family FCM34_02575 ENOG4105FAV ABC, transporter FCM34_02580 ENOG4105FDK ABC transporter FCM34_02585 ENOG4105NXV High-affinity zinc uptake system protein FCM34_02605 ENOG4105DR5 peptidase FCM34_02615 ENOG4105R2J Conserved Protein FCM34_02655 ENOG4108UW5 maltose o-acetyltransferase FCM34_02660 ENOG4105CG3 alpha amylase, catalytic region FCM34_02665 ENOG4105C5Y PTS System FCM34_02670 ENOG4105D4X repressor FCM34_02680 ENOG4105EIP mannose-6-phosphate isomerase FCM34_02685 ENOG4105CK1 PTS System FCM34_02690 ENOG4105VZJ PTS System FCM34_02695 ENOG4105CK1 PTS System FCM34_02700 ENOG4105CS2 ec 3.2.1.21 FCM34_02705 ENOG4105VCP PTS System FCM34_02710 ENOG4105DKQ ROK family FCM34_02740 ENOG4105DDV Transcriptional regulator (LacI family FCM34_02750 ENOG4105HDK L-asparaginase FCM34_02765 ENOG4108Z5K methylglyoxal synthase FCM34_02770 ENOG4108UQY Iron-storage protein FCM34_02785 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FCM34_02790 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FCM34_02800 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FCM34_02830 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FCM34_02835 ENOG4105C26 Dehydrogenase FCM34_02840 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FCM34_02845 ENOG4105D81 ABC transporter, permease FCM34_02850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FCM34_02855 ENOG4107TYH extracellular solute-binding protein family 1 FCM34_02860 ENOG4108M0I Transcriptional regulator FCM34_02865 ENOG4105DFD Na H antiporter FCM34_02905 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FCM34_02910 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FCM34_02915 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FCM34_02920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FCM34_02930 ENOG4107VXZ Hydrolase FCM34_02935 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FCM34_02940 ENOG4105F1S paraquat-inducible protein a FCM34_02945 ENOG4105DY2 Paraquat-inducible protein b FCM34_02950 ENOG4108Q2G (LipO)protein FCM34_02955 ENOG4105UYK outer membrane protein a FCM34_02975 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FCM34_02980 ENOG4105CEN a g-specific adenine glycosylase FCM34_02995 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FCM34_03000 ENOG4105CJ3 phosphate transporter FCM34_03005 ENOG4107IX6 phosphate transport regulator FCM34_03010 ENOG4105I7R Adenylate cyclase FCM34_03015 ENOG4108XTF Outer Membrane Lipoprotein FCM34_03020 ENOG4108R6G acetyltransferase FCM34_03035 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FCM34_03040 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FCM34_03045 ENOG4105VEJ Heat shock protein FCM34_03055 ENOG4105GVR general secretion pathway protein D FCM34_03060 ENOG4107QHF type ii secretion system protein e FCM34_03065 ENOG4105D7Q type ii secretion system FCM34_03070 ENOG4108VAU general secretion pathway protein G FCM34_03125 ENOG4108UDW Transcriptional regulator, luxr family FCM34_03130 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FCM34_03135 ENOG4105JQN Transcriptional regulator FCM34_03145 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FCM34_03150 ENOG4107RK2 ADP-ribose diphosphatase NudE FCM34_03155 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FCM34_03160 ENOG4105C44 Serine transporter FCM34_03165 ENOG4108Z7R Chaperone CsaA FCM34_03175 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FCM34_03180 ENOG4105C28 cystathionine FCM34_03185 ENOG4105CFH Aspartokinase FCM34_03190 ENOG41067MG lrgb family FCM34_03200 ENOG4105CMU LysR family (Transcriptional regulator FCM34_03235 ENOG4108Z66 YbaK ebsC protein FCM34_03240 ENOG4105BZU Histidine kinase FCM34_03245 ENOG4105BZU Histidine kinase FCM34_03250 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FCM34_03260 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FCM34_03265 ENOG4105CAS nag kinase FCM34_03275 ENOG4105CDH Citrulline--aspartate ligase FCM34_03280 ENOG4105CH7 arginosuccinase FCM34_03285 ENOG4107NQ8 LysR family Transcriptional regulator FCM34_03295 ENOG41090U3 tautomerase FCM34_03325 ENOG4108UW5 maltose o-acetyltransferase FCM34_03330 ENOG4107PU6 Membrane FCM34_03335 ENOG4105CT1 (ABC) transporter FCM34_03340 ENOG4105CDA abc transporter atp-binding protein FCM34_03345 ENOG4105E5Q amino acid AbC transporter FCM34_03350 ENOG4105E5Q amino acid AbC transporter FCM34_03355 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FCM34_03375 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FCM34_03380 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FCM34_03390 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_03395 ENOG4105EYW Ion transport protein FCM34_03400 ENOG4106MWK domain protein FCM34_03410 ENOG4105E09 nadh pyrophosphatase FCM34_03415 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FCM34_03420 ENOG4105DKQ ROK family FCM34_03425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FCM34_03430 ENOG4105BZA Phosphoglycerate kinase FCM34_03435 ENOG4105D2N Aldolase FCM34_03440 ENOG4105CJP fad dependent oxidoreductase FCM34_03450 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FCM34_03455 ENOG4105VF7 tolerance protein FCM34_03470 ENOG4105DUM transcriptional regulator, lysR family FCM34_03475 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FCM34_03480 ENOG4105Y75 tpr repeat protein FCM34_03490 ENOG4108IYU L-aspartate oxidase FCM34_03495 ENOG4105EMN RNA polymerase sigma factor FCM34_03500 ENOG41069PW sigma-e factor negative regulatory protein FCM34_03515 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FCM34_03520 ENOG4105C3F Signal peptidase i FCM34_03525 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FCM34_03535 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FCM34_03540 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FCM34_03545 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FCM34_03550 ENOG4108W15 Protein of unknown function (DUF1456) FCM34_03555 ENOG4105BZU Histidine kinase FCM34_03560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FCM34_03565 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FCM34_03570 ENOG4105DXN mazG family FCM34_03575 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FCM34_03580 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FCM34_03585 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FCM34_03590 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FCM34_03595 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FCM34_03600 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FCM34_03605 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FCM34_03610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FCM34_03615 ENOG4108UM1 dedA family FCM34_03620 ENOG4108K5P (LipO)protein FCM34_03630 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FCM34_03635 ENOG4105VCC 30S ribosomal protein S21 FCM34_03640 ENOG4105KTH gatB Yqey FCM34_03645 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FCM34_03650 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FCM34_03680 ENOG4105C12 Phosphoribosylglycinamide synthetase FCM34_03685 ENOG4105DC1 bifunctional purine biosynthesis protein purh FCM34_03705 ENOG4105CSA Coproporphyrinogen iii oxidase FCM34_03710 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FCM34_03720 ENOG4105D9R oxidoreductase FCM34_03730 ENOG4105G5H Membrane FCM34_03735 ENOG4107QX8 SPFH domain, Band 7 family protein FCM34_03740 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FCM34_03745 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FCM34_03750 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FCM34_03760 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FCM34_03765 ENOG4105VEQ Cold shock protein FCM34_03800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FCM34_03815 ENOG4108UUE Transcriptional regulator FCM34_03830 ENOG4105F0N pyrophosphate phospho-hydrolase FCM34_03835 ENOG4105DFU Cell wall formation (By similarity) FCM34_03840 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FCM34_03845 ENOG410630P Transcriptional regulator FCM34_03850 ENOG4108UGV hypoxanthine phosphoribosyltransferase FCM34_03855 ENOG4105DA5 (ABC) transporter FCM34_03860 ENOG4105E3A (ABC) transporter FCM34_03870 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FCM34_03875 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FCM34_03880 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FCM34_03885 ENOG4105DJ0 Poly(A) Polymerase FCM34_03890 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FCM34_03895 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FCM34_03900 ENOG4105PW4 Sugar fermentation stimulation protein homolog FCM34_03910 ENOG4105CQ7 ATP-dependent helicase FCM34_03915 ENOG4105BZ4 penicillin-binding protein FCM34_03920 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FCM34_03925 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FCM34_03930 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FCM34_03935 ENOG4105EGI Transcriptional regulator FCM34_03945 ENOG41076MN Phosphoesterase, PA-phosphatase related FCM34_03960 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FCM34_03965 ENOG4105CMQ Chloride channel FCM34_03975 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FCM34_04005 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FCM34_04010 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FCM34_04020 ENOG4107V40 secretion protein, HlyD family FCM34_04050 ENOG4105I93 response regulator FCM34_04055 ENOG4105DUX Transporter FCM34_04060 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FCM34_04065 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FCM34_04070 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FCM34_04075 ENOG4105K9H YciI-like protein FCM34_04080 ENOG4107835 probably involved in intracellular septation (By similarity) FCM34_04085 ENOG4105DY8 decarboxylase FCM34_04090 ENOG4108UT2 hemolysin iii FCM34_04095 ENOG4105D0C transport protein FCM34_04105 ENOG4105EV4 Multidrug resistance protein mdtH FCM34_04115 ENOG4105D4Y metalloprotease FCM34_04125 ENOG4105D9U N-acetyltransferase FCM34_04135 ENOG4105XEP YhcH YjgK YiaL family protein FCM34_04145 ENOG4105CUY Mechanosensitive ion channel FCM34_04150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FCM34_04155 ENOG4105CK7 Sodium proline symporter FCM34_04200 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FCM34_04205 ENOG4105D6S protein involved in catabolism of external DNA FCM34_04215 ENOG4105C5H ABC transporter FCM34_04220 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FCM34_04245 ENOG4107R88 Chemotaxis protein (CheV) FCM34_04250 ENOG4108UJV acyl-CoA thioesterase i FCM34_04255 ENOG4108I0Y (ABC) transporter FCM34_04260 ENOG4105CV6 ABC transporter, permease FCM34_04265 ENOG4105ECP epimerase FCM34_04270 ENOG4107XTP (EAL) domain protein FCM34_04275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FCM34_04280 ENOG4105IIU Aminopeptidase FCM34_04285 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FCM34_04290 ENOG41090ED Protein with unknown function (DUF469) FCM34_04295 ENOG4105CSV Glutaminase FCM34_04300 ENOG4107RM6 sulfurtransferase FCM34_04305 ENOG4105SUV lipoprotein YgdR FCM34_04310 ENOG4105BZ1 (ABC) transporter FCM34_04335 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FCM34_04340 ENOG4105BZU Histidine kinase FCM34_04360 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FCM34_04365 ENOG4105DJ4 phosphatidylserine decarboxylase FCM34_04370 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FCM34_04375 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FCM34_04415 ENOG4105VEQ Cold shock protein FCM34_04425 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_04430 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FCM34_04435 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FCM34_04440 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FCM34_04445 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FCM34_04495 ENOG4109015 Biopolymer transport protein exbD tolR FCM34_04525 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FCM34_04530 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FCM34_04545 ENOG4108JQ7 (ABC) transporter FCM34_04555 ENOG4105CIN aminoacyl-histidine dipeptidase FCM34_04565 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FCM34_04570 ENOG4105V1F Fermentation respiration switch protein FCM34_04575 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FCM34_04585 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FCM34_04620 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FCM34_04635 ENOG4105DG7 nitrate ABC transporter FCM34_04640 ENOG4105D7T ABC transporter FCM34_04645 ENOG4107QZF nitrite reductase NADPH large subunit FCM34_04650 ENOG4107QZF nitrite reductase NADPH large subunit FCM34_04655 ENOG4105DD7 kinase (PfkB family FCM34_04660 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FCM34_04680 ENOG4108RIR Molybdenum cofactor biosynthesis protein FCM34_04690 ENOG4105DWK Membrane FCM34_04695 ENOG4107XM3 UPF0442 protein FCM34_04705 ENOG4108IJ7 Glycine betaine FCM34_04710 ENOG4108HQS Glycine betaine FCM34_04715 ENOG4105GIJ Glycine betaine FCM34_04720 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FCM34_04725 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FCM34_04730 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FCM34_04735 ENOG4107TIF Phenazine biosynthesis protein, PhzF family FCM34_04740 ENOG4105CRK lysyL-tRNA synthetase FCM34_04750 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_04755 ENOG4105D6U Sodium Glutamate Symporter FCM34_04760 ENOG4105HDK L-asparaginase FCM34_04765 ENOG4105VUT cytoplasmic protein FCM34_04785 ENOG4105D07 Signal peptide peptidase, SppA FCM34_04790 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FCM34_04795 ENOG41069NU Nitroreductase FCM34_04800 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_04805 ENOG4108UW5 maltose o-acetyltransferase FCM34_04810 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FCM34_04815 ENOG4105CIS alcohol dehydrogenase FCM34_04820 ENOG4105HEI LysR family (Transcriptional regulator FCM34_04825 ENOG4105CI1 PTS System FCM34_04830 ENOG4108IA2 Sodium pantothenate symporter FCM34_04835 ENOG4105RG0 Membrane FCM34_04840 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FCM34_04845 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FCM34_04850 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FCM34_04855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FCM34_04860 ENOG4105BZU Histidine kinase FCM34_04870 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FCM34_04880 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FCM34_04890 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FCM34_04895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FCM34_04910 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FCM34_04915 ENOG4107YIM Involved in the transcription termination process (By similarity) FCM34_04920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FCM34_04925 ENOG4108ZAI phosphatidylglycerophosphatase a FCM34_04930 ENOG4108JQ6 ABC transporter FCM34_04940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FCM34_04945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FCM34_04950 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FCM34_04955 ENOG4105CTB Polyprenyl synthetase FCM34_04960 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FCM34_04965 ENOG4105E14 MotA TolQ exbB proton channel FCM34_04970 ENOG4107XSU flagellar motor protein motb FCM34_04975 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FCM34_04985 ENOG4105HBR Rna-binding protein FCM34_04990 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FCM34_04995 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FCM34_05000 ENOG4105EEI dihydropteroate synthase FCM34_05005 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FCM34_05010 ENOG4105CP7 Triose-phosphate isomerase FCM34_05030 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FCM34_05035 ENOG4105CHV Transcription elongation factor NusA FCM34_05040 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FCM34_05045 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FCM34_05050 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FCM34_05055 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FCM34_05065 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FCM34_05070 ENOG4105E5W Transporter FCM34_05075 ENOG41090EX DsrE family FCM34_05080 ENOG4105WAY exported protein FCM34_05095 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FCM34_05100 ENOG4105CFP Peptidase U32 FCM34_05110 ENOG4105BZU Histidine kinase FCM34_05115 ENOG4105BZU Histidine kinase FCM34_05135 ENOG4105BZU Histidine kinase FCM34_05155 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FCM34_05175 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FCM34_05180 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FCM34_05185 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FCM34_05195 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FCM34_05200 ENOG4107SWG transcriptional regulator MERR family FCM34_05215 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_05225 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FCM34_05230 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FCM34_05235 ENOG4108Z43 UPF0250 protein FCM34_05240 ENOG4105DZ1 carboxypeptidase FCM34_05245 ENOG4105K6T rare lipoprotein A FCM34_05250 ENOG4105CVE Lytic murein transglycosylase FCM34_05255 ENOG4105CNI cell division protein FtsW FCM34_05260 ENOG4105CJN penicillin-binding protein FCM34_05265 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FCM34_05270 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FCM34_05275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FCM34_05290 ENOG4105C8T Leucyl-tRNA synthetase FCM34_05295 ENOG4107PAI alpha helical protein FCM34_05300 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FCM34_05305 ENOG4108JU5 Magnesium and cobalt efflux protein FCM34_05310 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FCM34_05315 ENOG4105C9A Phoh family FCM34_05320 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FCM34_05325 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FCM34_05330 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FCM34_05335 ENOG4105VEQ Cold shock protein FCM34_05350 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FCM34_05365 ENOG4108KHX Diguanylate cyclase FCM34_05375 ENOG4105C5I Dehydrogenase FCM34_05390 ENOG4105D01 (LipO)protein FCM34_05395 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FCM34_05400 ENOG4108UMI ABC transporter, permease FCM34_05410 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FCM34_05420 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FCM34_05425 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FCM34_05430 ENOG4105DHQ Histidine kinase FCM34_05435 ENOG4105XJC Two component transcriptional regulator (Winged helix family FCM34_05445 ENOG4108IXY short-chain dehydrogenase reductase FCM34_05465 ENOG4106371 Methyltransferase FCM34_05470 ENOG4105T0Z Conserved Protein FCM34_05485 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FCM34_05490 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FCM34_05495 ENOG4105E33 succinate dehydrogenase FCM34_05505 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_05510 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FCM34_05515 ENOG4105EGS Mechanosensitive ion channel FCM34_05525 ENOG4105DR5 peptidase FCM34_05540 ENOG4105EJC lysr family transcriptional regulator FCM34_05555 ENOG4105C5Q Transcriptional regulator FCM34_05560 ENOG4108JQC penicillin-binding protein 1A FCM34_05585 ENOG4105E4G Type IV pilus FCM34_05590 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FCM34_05595 ENOG4105D49 3-dehydroquinate synthase FCM34_05605 ENOG4105DFE Dna adenine methylase FCM34_05610 ENOG4105DJV ribulose-phosphate 3-epimerase FCM34_05615 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FCM34_05620 ENOG4105C31 Tryptophanyl-tRNA synthetase FCM34_05635 ENOG4105C8Y Acetylornithine aminotransferase FCM34_05640 ENOG4105F4X arginine FCM34_05645 ENOG4105C26 Dehydrogenase FCM34_05660 ENOG4107VXZ Hydrolase FCM34_05680 ENOG41060QA UPF0267 protein FCM34_05685 ENOG4107QWE )-transporter FCM34_05730 ENOG4105C3G gtp-binding protein FCM34_05735 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FCM34_05740 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FCM34_05750 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FCM34_05755 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FCM34_05760 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FCM34_05765 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FCM34_05770 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FCM34_05780 ENOG41063JG Transcriptional regulator FCM34_05785 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FCM34_05790 ENOG4105CK2 sodium dicarboxylate symporter FCM34_05795 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FCM34_05800 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FCM34_05815 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FCM34_05820 ENOG4105BZG amino acid carrier protein FCM34_05825 ENOG41066YJ Beta-lactamase FCM34_05840 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FCM34_05845 ENOG4108UJU UPF0301 protein FCM34_05850 ENOG4105D7Z glutathione synthase FCM34_05855 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FCM34_05865 ENOG4105GPY SprT protein FCM34_05870 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FCM34_05875 ENOG4105CV1 Transketolase (EC 2.2.1.1) FCM34_05885 ENOG4105KME endoribonuclease L-psp FCM34_05900 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FCM34_05905 ENOG4105DR5 peptidase FCM34_05910 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FCM34_05915 ENOG4107WCA isomerase FCM34_05925 ENOG4108V1U phospholipid-binding protein FCM34_05930 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FCM34_05945 ENOG4105C87 Aminotransferase class I and II FCM34_05955 ENOG4105C5Q Transcriptional regulator FCM34_05960 ENOG4105UBK short-chain dehydrogenase reductase FCM34_05965 ENOG4105ERU peptidase FCM34_05970 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FCM34_05975 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FCM34_05985 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FCM34_05990 ENOG4105E2D ec 3.2.1.52 FCM34_05995 ENOG4105RD7 BadF BadG BcrA BcrD FCM34_06005 ENOG4108JQ7 (ABC) transporter FCM34_06015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FCM34_06030 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FCM34_06035 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FCM34_06040 ENOG41085FC arsR family transcriptional regulator FCM34_06045 ENOG4105D6J arsenicaL-resistance protein FCM34_06050 ENOG4105K89 arsenate reductase FCM34_06060 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FCM34_06065 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FCM34_06070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FCM34_06080 ENOG4108JIR Flagellum-specific ATP synthase FCM34_06100 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FCM34_06105 ENOG4105DD5 Flagellar motor switch protein FCM34_06110 ENOG4105VTB flagellar biosynthesis protein fliO FCM34_06115 ENOG4105CN7 Flagellar biosynthetic protein FliP FCM34_06120 ENOG4105VS8 Flagellar biosynthetic protein fliq FCM34_06125 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FCM34_06130 ENOG4105D00 flagellar biosynthetic protein flhB FCM34_06135 ENOG4105D7B Flagellar biosynthesis protein flha FCM34_06140 ENOG4105FZW flagellar biosynthesis regulator FlhF FCM34_06150 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FCM34_06155 ENOG4108VYJ response regulator receiver protein FCM34_06160 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FCM34_06165 ENOG4105CBS Chea signal transduction histidine kinase FCM34_06170 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FCM34_06175 ENOG4105E14 MotA TolQ exbB proton channel FCM34_06180 ENOG4108SEK ompa motb domain protein FCM34_06185 ENOG4107QJE Chromosome Partitioning Protein FCM34_06195 ENOG4108V3W Chemotaxis protein, CheW FCM34_06210 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FCM34_06215 ENOG41060IM Heme exporter protein FCM34_06220 ENOG4105X3C heme exporter protein FCM34_06225 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FCM34_06230 ENOG4105DA4 cytochrome c-type biogenesis protein FCM34_06235 ENOG4107QX9 Thiol disulfide interChange protein FCM34_06240 ENOG4105KWW Biogenesis protein FCM34_06250 ENOG410903C (LipO)protein FCM34_06255 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FCM34_06260 ENOG4105M2J Glutaredoxin FCM34_06280 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FCM34_06285 ENOG4107R11 Transcriptional regulator FCM34_06310 ENOG4108YYD acetyltransferase FCM34_06350 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FCM34_06355 ENOG4105BZS acriflavin resistance protein FCM34_06360 ENOG4105C1P efflux transporter, rnd family, mfp subunit FCM34_06365 ENOG4105RJZ Transcriptional regulator FCM34_06430 ENOG4105DZR Type I site-specific deoxyribonuclease FCM34_06510 ENOG4108NF7 phage-type endonuclease FCM34_06520 ENOG4105XUP Phage derived protein Gp49-like (DUF891) FCM34_06540 ENOG4108P8R FCM34_06545 ENOG4105JXR Protein of unknown function (DUF3296) FCM34_06555 ENOG4105DFP Integrase FCM34_06560 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FCM34_06610 ENOG4105DH7 May be involved in recombination (By similarity) FCM34_06645 ENOG41076J9 exonuclease VIII FCM34_06715 ENOG4105CDU Replicative dna helicase FCM34_06740 ENOG4105NY2 NinB protein FCM34_06920 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FCM34_06925 ENOG4108Z1B Cyclase dehydrase FCM34_06930 ENOG4105VDB UPF0125 protein FCM34_06935 ENOG4105K4T epimerase FCM34_06940 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FCM34_06945 ENOG4105C0A alcohol dehydrogenase FCM34_06950 ENOG4108I5U Uridine phosphorylase FCM34_06955 ENOG4105D3G Pseudouridine synthase FCM34_06960 ENOG4105DU0 nucleoside hydrolase FCM34_06975 ENOG4105RX8 Protein of unknown function (DUF1523) FCM34_06980 ENOG4108NVR Methyl-accepting chemotaxis FCM34_06985 ENOG410829K Lysine exporter protein (Lyse ygga) FCM34_06995 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FCM34_07010 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FCM34_07015 ENOG4105KUZ arsenate reductase FCM34_07025 ENOG4105CEE C4-dicarboxylate transporter FCM34_07045 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FCM34_07050 ENOG4105C5S asparaginyl-tRNA synthetase FCM34_07070 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FCM34_07075 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FCM34_07080 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FCM34_07085 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FCM34_07090 ENOG4105D0M Protease HtpX homolog FCM34_07095 ENOG4105QVC MOSC domain-containing protein FCM34_07095 ENOG4105QVC MOSC domain-containing protein FCM34_07105 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FCM34_07110 ENOG4105Z2P Protein of unknown function (DUF465) FCM34_07120 ENOG4105UQX Mate efflux family protein FCM34_07140 ENOG4105C6T cysteine synthase FCM34_07145 ENOG4105C0A alcohol dehydrogenase FCM34_07155 ENOG4107Z3H Transcriptional regulator, TetR family FCM34_07160 ENOG4107RGH Aldehyde dehydrogenase FCM34_07170 ENOG4108QBX (LipO)protein FCM34_07175 ENOG4105C5Q Transcriptional regulator FCM34_07195 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FCM34_07200 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FCM34_07205 ENOG41081XQ Conserved Protein FCM34_07215 ENOG4105C9M aspartyl-trna synthetase FCM34_07220 ENOG4105CDY transcriptional regulatory protein FCM34_07225 ENOG4105DIJ Phosphoethanolamine transferase FCM34_07230 ENOG4105E2R ROK family FCM34_07235 ENOG4105CE4 GlcNAc 6-P deacetylase FCM34_07240 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FCM34_07245 ENOG4105CI1 PTS System FCM34_07250 ENOG4105E2D ec 3.2.1.52 FCM34_07255 ENOG4105CX6 glutaminyL-tRNA synthetase FCM34_07260 ENOG41090R7 Ferric uptake FCM34_07270 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FCM34_07275 ENOG4105NNH LexA regulated protein FCM34_07285 ENOG4105EV9 Alpha Beta Hydrolase FCM34_07290 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FCM34_07295 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FCM34_07305 ENOG41090MY MarR family Transcriptional regulator FCM34_07310 ENOG4105CVE Lytic murein transglycosylase FCM34_07315 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FCM34_07320 ENOG4108VGW abc transporter atp-binding protein FCM34_07330 ENOG4105VNH ABC transporter solute-binding protein FCM34_07340 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FCM34_07350 ENOG4105F2I Transposase FCM34_07355 ENOG4107TII Recombinase FCM34_07360 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FCM34_07370 ENOG4105CFU surface antigen FCM34_07375 ENOG4105MA0 exported protein FCM34_07395 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FCM34_07400 ENOG4105BZU Histidine kinase FCM34_07405 ENOG4107SC1 transglycosylase FCM34_07410 ENOG41060NJ transcriptional regulator FCM34_07420 ENOG4105NAU thioesterase Superfamily protein FCM34_07430 ENOG4107NA1 Endonuclease Exonuclease phosphatase FCM34_07435 ENOG4105E9H Lytic Murein transglycosylase FCM34_07440 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FCM34_07445 ENOG4105D1A Methyltransferase FCM34_07450 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FCM34_07455 ENOG4107RZZ dna polymerase iii epsilon subunit FCM34_07465 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FCM34_07470 ENOG4107QPN acyl-Coa dehydrogenase FCM34_07475 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FCM34_07480 ENOG4105E7A Glutamine amidotransferase FCM34_07490 ENOG4105CHW UPF0052 protein FCM34_07500 ENOG4105BZU Histidine kinase FCM34_07515 ENOG4105WH1 Two component transcriptional regulator luxr family FCM34_07520 ENOG4105BZU Histidine kinase FCM34_07525 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FCM34_07530 ENOG4108ZNS ferredoxin-type protein NapF FCM34_07540 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FCM34_07545 ENOG4108BGM Quinol dehydrogenase periplasmic component FCM34_07550 ENOG4105GXZ Ferredoxin-type protein NapH FCM34_07560 ENOG4105CUW cytochrome C-TYPE protein FCM34_07565 ENOG4108RIR Molybdenum cofactor biosynthesis protein FCM34_07570 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FCM34_07575 ENOG4105M00 molybdopterin converting factor, subunit 1 FCM34_07580 ENOG4108ZAF Molybdopterin FCM34_07585 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FCM34_07590 ENOG4105E0C molybdate abc transporter FCM34_07595 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FCM34_07600 ENOG410832A alpha/beta hydrolase fold FCM34_07605 ENOG4105D06 uba thif-type nad fad binding protein FCM34_07610 ENOG4105CVM Molybdenum cofactor synthesis domain protein FCM34_07615 ENOG4105EUJ GTP cyclohydrolase i FCM34_07620 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_07625 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_07630 ENOG4105CKU formyltetrahydrofolate synthetase FCM34_07640 ENOG4105CC0 LysR family Transcriptional regulator FCM34_07645 ENOG4108YYC ycei family FCM34_07655 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FCM34_07670 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FCM34_07685 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FCM34_07700 ENOG4105BZU Histidine kinase FCM34_07720 ENOG4105D70 Integrase catalytic subunit FCM34_07745 ENOG4105D7V transposase FCM34_07755 ENOG4105D82 Glutamate dehydrogenase FCM34_07760 ENOG4105FE9 pseudouridine synthase FCM34_07765 ENOG4105DJ2 Major Facilitator Superfamily FCM34_07775 ENOG4105C5Q Transcriptional regulator FCM34_07785 ENOG4106428 Protein of unknown function (DUF2496) FCM34_07795 ENOG4108Q2J Inner membrane protein YebE FCM34_07805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FCM34_07810 ENOG4105C4M (Ubiquinol oxidase) subunit I FCM34_07815 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FCM34_07825 ENOG4105F27 Major Facilitator FCM34_07830 ENOG4105CV8 reductase FCM34_07850 ENOG4105HEI LysR family (Transcriptional regulator FCM34_07855 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FCM34_07860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FCM34_07865 ENOG4105CXY transporter FCM34_07870 ENOG4105E98 transcriptional regulator DeoR family FCM34_07875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FCM34_07880 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FCM34_07885 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FCM34_07900 ENOG4108WFC UPF0438 protein yifE FCM34_07905 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) FCM34_07925 ENOG4105CUG Oligopeptidase b FCM34_07930 ENOG4105D05 Receptor FCM34_07935 ENOG4105E68 Sulfatase FCM34_07940 ENOG4105PAN UPF0352 protein FCM34_07945 ENOG4106V8H Nucleoid-associated protein FCM34_07950 ENOG4107FKK extracellular solute-binding protein family 1 FCM34_07955 ENOG4105D56 permease protein FCM34_07960 ENOG4105EG2 ABC transporter, permease FCM34_07965 ENOG4108IJ9 (ABC) transporter FCM34_07970 ENOG4105CSR polyphosphate kinase 2 FCM34_07975 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FCM34_07990 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FCM34_07995 ENOG4105ERG peptidase m48, ste24p FCM34_08005 ENOG4105K89 arsenate reductase FCM34_08020 ENOG4108ZYK Acyl carrier protein phosphodiesterase FCM34_08030 ENOG4106PMH Extracellular solute-binding protein family 3 FCM34_08035 ENOG4105DYB Isoaspartyl dipeptidase FCM34_08040 ENOG4105DWU Membrane FCM34_08045 ENOG4108JEH abc transporter atp-binding protein FCM34_08050 ENOG4106PMH Extracellular solute-binding protein family 3 FCM34_08055 ENOG4105DSP amino acid AbC transporter FCM34_08060 ENOG4106YG3 ABC transporter FCM34_08070 ENOG4105F1A Pyruvate formate-lyase FCM34_08075 ENOG4105BZU Histidine kinase FCM34_08080 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FCM34_08085 ENOG4105DN3 alpha-2-macroglobulin domain protein FCM34_08090 ENOG4108JQB penicillin-binding protein 1C FCM34_08100 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FCM34_08110 ENOG4105EN6 Membrane FCM34_08115 ENOG4105I03 Flagellin FCM34_08120 ENOG41063QE flagellar protein FlaG FCM34_08130 ENOG4105MQ3 flagellar protein FliS FCM34_08145 ENOG4105F2I Transposase FCM34_08155 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FCM34_08165 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FCM34_08190 ENOG4108UYE Lactoylglutathione lyase FCM34_08195 ENOG4105CSM endonuclease III FCM34_08200 ENOG4105DZB Electron transport complex FCM34_08205 ENOG4108UQQ Electron transport complex FCM34_08210 ENOG4105D6A Electron transport complex FCM34_08220 ENOG4108R3D Electron transport complex FCM34_08225 ENOG4105DGN Electron transport complex FCM34_08230 ENOG4105D7V transposase FCM34_08240 ENOG4108PCN EamA-like transporter family FCM34_08250 ENOG4107SDU Methyl-accepting chemotaxis FCM34_08265 ENOG4105RKW reductase (By FCM34_08270 ENOG4105CSX c4-dicarboxylate anaerobic carrier FCM34_08275 ENOG4105CHM Aminotransferase FCM34_08285 ENOG41090BQ Glutaredoxin FCM34_08290 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FCM34_08295 ENOG4105CFI type iii restriction protein res subunit FCM34_08300 ENOG4105EFX secretion protein, HlyD family FCM34_08320 ENOG4105EGS Mechanosensitive ion channel FCM34_08330 ENOG4108NEV two component transcriptional regulator, LytTR family FCM34_08335 ENOG4108HRK Histidine kinase FCM34_08340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FCM34_08345 ENOG4108EKI Dehydrogenase FCM34_08350 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FCM34_08355 ENOG4107QSI ABC, transporter FCM34_08360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FCM34_08365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FCM34_08370 ENOG4105C3U ABC transporter FCM34_08375 ENOG4108JQ7 (ABC) transporter FCM34_08380 ENOG4105DU1 integral membrane protein, terc FCM34_08385 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FCM34_08395 ENOG4107QJT sodium dicarboxylate symporter FCM34_08415 ENOG4105CD3 dihydroorotase FCM34_08425 ENOG4108NVR Methyl-accepting chemotaxis FCM34_08430 ENOG4105K59 histidine triad (HIT) protein FCM34_08465 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FCM34_08470 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FCM34_08475 ENOG4107SDU Methyl-accepting chemotaxis FCM34_08485 ENOG4105CKW Inner membrane protein yedI FCM34_08490 ENOG4105DPN Oligoendopeptidase f FCM34_08495 ENOG4105DPN Oligoendopeptidase f FCM34_08505 ENOG4105CEP NADH dehydrogenase FCM34_08510 ENOG4105K8R UPF0145 protein FCM34_08515 ENOG4107T7U Sulfatase FCM34_08525 ENOG4105CFH Aspartokinase FCM34_08530 ENOG4107QZM n-acetylglutamate synthase FCM34_08535 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FCM34_08560 ENOG4105CR8 Transcriptional regulator FCM34_08565 ENOG4105DAA L-lactate FCM34_08570 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FCM34_08575 ENOG4107QR9 Iron-sulfur cluster binding protein FCM34_08580 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FCM34_08595 ENOG4105F2I Transposase FCM34_08615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FCM34_08635 ENOG4105C2C drug resistance transporter, Bcr CflA FCM34_08700 ENOG4105E1F short-chain dehydrogenase reductase FCM34_08725 ENOG4105CHH sulfate transporter FCM34_08780 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FCM34_08785 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FCM34_08790 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FCM34_08795 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FCM34_08800 ENOG4105WJG Glutathione FCM34_08805 ENOG4107RE1 Inosine-guanosine kinase FCM34_08810 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_08825 ENOG4105BZU Histidine kinase FCM34_08840 ENOG4105F3T (LipO)protein FCM34_08850 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FCM34_08855 ENOG4105WQI isochorismatase FCM34_08860 ENOG4105CEY Amp-dependent synthetase and ligase FCM34_08865 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FCM34_08895 ENOG4105CEY Amp-dependent synthetase and ligase FCM34_08900 ENOG4105J76 Periplasmic binding protein FCM34_08905 ENOG4108TSE Transferase FCM34_08910 ENOG4105E0A ABC, transporter FCM34_08915 ENOG4105TVJ transport system, permease FCM34_08920 ENOG4105DQ5 transport system permease protein FCM34_08925 ENOG4105D05 Receptor FCM34_08940 ENOG4105QZU Inner membrane protein YfeZ FCM34_08945 ENOG4107QUT magnesium and cobalt transport protein CorA FCM34_08950 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FCM34_08955 ENOG4105BZJ Electron transfer flavoprotein FCM34_08960 ENOG4105C10 Electron transfer flavoprotein FCM34_08965 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FCM34_08970 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FCM34_08975 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FCM34_08980 ENOG4105EE5 Membrane protein terC FCM34_08990 ENOG4105MH2 YfcL protein FCM34_08995 ENOG4108IQE Amp-dependent synthetase and ligase FCM34_09000 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FCM34_09005 ENOG41067MG lrgb family FCM34_09010 ENOG4105VAW lrga family FCM34_09015 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 FCM34_09025 ENOG4105CJB Exodeoxyribonuclease I FCM34_09035 ENOG4108J1Q FCM34_09040 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FCM34_09045 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FCM34_09050 ENOG4105CMR udp-glucose 4-epimerase FCM34_09055 ENOG41060NJ transcriptional regulator FCM34_09060 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FCM34_09075 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_09085 ENOG4107FKK extracellular solute-binding protein family 1 FCM34_09095 ENOG4105EG2 ABC transporter, permease FCM34_09105 ENOG4105C4C beta-galactosidase FCM34_09110 ENOG4105CI1 PTS System FCM34_09120 ENOG4105CA9 Pyruvate kinase FCM34_09140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FCM34_09145 ENOG4105FF5 Membrane FCM34_09155 ENOG4105E89 ABC transporter FCM34_09165 ENOG4105CHM Aminotransferase FCM34_09170 ENOG4105ETT transcriptional Regulator, LysR family FCM34_09175 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FCM34_09185 ENOG4105EF1 ribulokinase FCM34_09190 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FCM34_09200 ENOG4105CNN ABC, transporter FCM34_09215 ENOG4105NRA 50s ribosomal protein l31 type b FCM34_09230 ENOG4108VKG metal-dependent hydrolase FCM34_09245 ENOG4105CEE C4-dicarboxylate transporter FCM34_09255 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FCM34_09260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FCM34_09275 ENOG4105BZN citrate synthase FCM34_09280 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FCM34_09285 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FCM34_09290 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FCM34_09295 ENOG4105E33 succinate dehydrogenase FCM34_09300 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FCM34_09305 ENOG4105C7S Dehydrogenase FCM34_09310 ENOG4105CMV Succinyl-CoA synthetase subunit beta FCM34_09315 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FCM34_09330 ENOG4105C6N Formate acetyltransferase FCM34_09335 ENOG4105TMB Formate nitrite transporter FCM34_09340 ENOG4105DDY UPF0142 protein ycaO FCM34_09350 ENOG4105KPY Small multidrug resistance protein FCM34_09355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FCM34_09360 ENOG4105VEQ Cold shock protein FCM34_09365 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FCM34_09370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FCM34_09375 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FCM34_09380 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FCM34_09385 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FCM34_09390 ENOG4107MBR 17 kDa surface antigen FCM34_09395 ENOG4105BZU Histidine kinase FCM34_09400 ENOG4105C3M thioredoxin reductase FCM34_09405 ENOG4105DCF alanine dehydrogenase FCM34_09410 ENOG4105EW9 transcriptional regulator AsnC family FCM34_09415 ENOG4105CNU cell division protein FtsK FCM34_09420 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FCM34_09425 ENOG4105D1H recombination factor protein RarA FCM34_09435 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FCM34_09440 ENOG4105E96 Colicin v production protein FCM34_09445 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FCM34_09450 ENOG4105CS2 ec 3.2.1.21 FCM34_09455 ENOG4105C5Y PTS System FCM34_09460 ENOG4105DDV Transcriptional regulator (LacI family FCM34_09465 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FCM34_09470 ENOG4108JQ2 peptide transport system atp-binding protein FCM34_09475 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FCM34_09480 ENOG4108EU3 peptide transport system, permease FCM34_09485 ENOG4108I5W peptide transport system, permease protein FCM34_09490 ENOG4108J59 Extracellular solute-binding protein, family 5 FCM34_09495 ENOG4105E51 psp operon transcriptional activator FCM34_09500 ENOG41087YS Phage shock protein A FCM34_09505 ENOG4105YYT phage shock protein B FCM34_09515 ENOG4105CM6 amino acid regulated cytosolic protein FCM34_09520 ENOG4106K28 UPF0283 membrane protein FCM34_09525 ENOG4105MIR Phenylalanine 4-monooxygenase FCM34_09530 ENOG41090A4 Pterin carbinolamine dehydratase FCM34_09540 ENOG4108WS1 FCM34_09550 ENOG41090EK ompa motb domain protein FCM34_09555 ENOG4105D4P Coproporphyrinogen iii oxidase FCM34_09560 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FCM34_09580 ENOG4105D7V transposase FCM34_09595 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FCM34_09600 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FCM34_09610 ENOG4105DFP Integrase FCM34_09730 ENOG4108R0M Aminoglycoside FCM34_09735 ENOG4108C33 Resolvase FCM34_09785 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FCM34_09805 ENOG4105C5H ABC transporter FCM34_09815 ENOG4105C94 Transporter FCM34_09820 ENOG4105RHY Pfam:UPF0157 FCM34_09830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FCM34_09850 ENOG41082F9 transcriptional regulator FCM34_09860 ENOG4105FQ6 thiopurine methyltransferase FCM34_09865 ENOG4107QXK peptidase FCM34_09870 ENOG4108BY2 phosphohistidine phosphatase FCM34_09880 ENOG4108IPJ Membrane FCM34_09885 ENOG4107QSI ABC, transporter FCM34_09895 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FCM34_09900 ENOG4108JA2 transcriptioN-repair coupling factor FCM34_09910 ENOG4105D60 lipoprotein releasing system transmembrane protein FCM34_09915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FCM34_09920 ENOG4105D60 lipoprotein releasing system transmembrane protein FCM34_09940 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FCM34_09945 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FCM34_09950 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FCM34_09955 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FCM34_09960 ENOG4105K70 DNA-binding protein FCM34_09965 ENOG4105EIN peptidylprolyl cis-trans isomerase FCM34_09970 ENOG4105C5H ABC transporter FCM34_09975 ENOG4107QN1 sodium solute FCM34_09980 ENOG41062QD Membrane FCM34_09995 ENOG41060WC Enoyl-CoA hydratase FCM34_10000 ENOG4105BZG amino acid carrier protein FCM34_10010 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FCM34_10015 ENOG4106HK8 GPR1 FUN34 yaaH family protein FCM34_10030 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FCM34_10040 ENOG4105E39 Enoyl-CoA hydratase FCM34_10045 ENOG4107QX3 carboxylase FCM34_10050 ENOG4105C1G acyl-Coa dehydrogenase FCM34_10055 ENOG4105C26 Dehydrogenase FCM34_10060 ENOG4105C1G acyl-Coa dehydrogenase FCM34_10065 ENOG4105E39 Enoyl-CoA hydratase FCM34_10070 ENOG4105E39 Enoyl-CoA hydratase FCM34_10075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FCM34_10085 ENOG4105D5Q Arginine ornithine antiporter FCM34_10090 ENOG4105HF0 Membrane FCM34_10140 ENOG4105VTR Integrase FCM34_10155 ENOG4105F5W AtP-binding protein FCM34_10180 ENOG4105CVR type I restriction-modification system FCM34_10210 ENOG4105W5Q DNA repair protein (RadC FCM34_10250 ENOG41062B0 ABC transporter, permease FCM34_10255 ENOG4107R9N ABC transporter FCM34_10260 ENOG4105C2J ABC transporter FCM34_10265 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FCM34_10270 ENOG4105DND Transcriptional regulator FCM34_10285 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FCM34_10290 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FCM34_10295 ENOG4105BZU Histidine kinase FCM34_10300 ENOG4108KB2 LysR family Transcriptional regulator FCM34_10305 ENOG4105CS2 ec 3.2.1.21 FCM34_10310 ENOG4105CHR reductase FCM34_10315 ENOG4105CBN LysR family transcriptional regulator FCM34_10330 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FCM34_10340 ENOG4105DUM transcriptional regulator, lysR family FCM34_10350 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FCM34_10355 ENOG4105D1S lipid A biosynthesis FCM34_10365 ENOG4105EUB pirin domain protein FCM34_10370 ENOG4105CQ2 DNA polymerase FCM34_10400 ENOG4107QI1 Mate efflux family protein FCM34_10405 ENOG4105W1I UPF0253 protein FCM34_10410 ENOG4108R6K riboflavin synthase, subunit alpha FCM34_10425 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FCM34_10430 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FCM34_10435 ENOG4108SXK Transporter Drug Metabolite Exporter family FCM34_10440 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FCM34_10475 ENOG4105QNR S1 RNA binding domain protein FCM34_10485 ENOG4105XW2 UPF0263 protein FCM34_10490 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FCM34_10500 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FCM34_10505 ENOG4107QMS site-determining protein FCM34_10510 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FCM34_10515 ENOG4105VNG YcgL domain-containing protein FCM34_10520 ENOG4105CVE Lytic murein transglycosylase FCM34_10525 ENOG4105EJQ L-serine dehydratase FCM34_10535 ENOG4105EJQ L-serine dehydratase FCM34_10540 ENOG4105NBK UPF0345 protein FCM34_10545 ENOG4105CK2 sodium dicarboxylate symporter FCM34_10555 ENOG4105CHU acetyl-coa acetyltransferase FCM34_10560 ENOG4105D58 Diguanylate phosphodiesterase FCM34_10565 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FCM34_10570 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FCM34_10610 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FCM34_10615 ENOG4105CHU acetyl-coa acetyltransferase FCM34_10620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FCM34_10630 ENOG4108VWS Yaeq family FCM34_10650 ENOG4105EHG Permease protein FCM34_10665 ENOG4107MBR 17 kDa surface antigen FCM34_10690 ENOG4105D29 Helix-turn-helix type 11 domain protein FCM34_10700 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FCM34_10705 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FCM34_10710 ENOG4105BZU Histidine kinase FCM34_10720 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FCM34_10725 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FCM34_10730 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FCM34_10740 ENOG4105CIH Imidazole acetol-phosphate transaminase FCM34_10745 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FCM34_10750 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FCM34_10760 ENOG4105DVT helicase FCM34_10765 ENOG41072GX Peptidase M22 Glycoprotease FCM34_10775 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FCM34_10780 ENOG4105CEY Amp-dependent synthetase and ligase FCM34_10795 ENOG4105DXC membrane FCM34_10805 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FCM34_10810 ENOG4105WD1 Membrane FCM34_10815 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FCM34_10820 ENOG4107QMP dna polymerase iii subunits gamma and tau FCM34_10825 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FCM34_10830 ENOG4105CR8 Transcriptional regulator FCM34_10835 ENOG4105EUB pirin domain protein FCM34_10840 ENOG4105DWD nucleoside recognition domain protein FCM34_10845 ENOG4105WH1 Two component transcriptional regulator luxr family FCM34_10855 ENOG4105CQ7 ATP-dependent helicase FCM34_10865 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FCM34_10870 ENOG4105BZU Histidine kinase FCM34_10880 ENOG4105C5X domain protein FCM34_10885 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FCM34_10890 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FCM34_10905 ENOG4105DR4 Methyltransferase FCM34_10910 ENOG4108N3W hemolysin secretion protein FCM34_10915 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FCM34_10925 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FCM34_10930 ENOG4105D1F ATP-binding protein FCM34_10935 ENOG4105DBI uridine monophosphokinase FCM34_10940 ENOG4105DHP deoxycytidine triphosphate deaminase FCM34_10945 ENOG4105CJ3 phosphate transporter FCM34_10950 ENOG4105C03 ribonuclease FCM34_10955 ENOG4105EI2 Pseudouridine synthase FCM34_10960 ENOG4108UHJ MAF-like protein FCM34_10970 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FCM34_10975 ENOG4105VGS 50s ribosomal protein l32 FCM34_10980 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FCM34_10985 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FCM34_10990 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FCM34_10995 ENOG4105CHR reductase FCM34_11000 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FCM34_11005 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FCM34_11010 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FCM34_11015 ENOG4105HHA aminodeoxychorismate lyase FCM34_11020 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FCM34_11025 ENOG4107QRG dna polymerase iii FCM34_11030 ENOG4105F8V Hydrolase, tatD family FCM34_11045 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FCM34_11050 ENOG4105DY2 Paraquat-inducible protein b FCM34_11055 ENOG4105H2K paraquat-inducible protein a FCM34_11065 ENOG4105X2V dna damage-inducible protein FCM34_11075 ENOG4105DAN ATP-dependent protease FCM34_11080 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FCM34_11085 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FCM34_11095 ENOG4105C5H ABC transporter FCM34_11105 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FCM34_11110 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FCM34_11115 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FCM34_11120 ENOG4105C7I Dehydrogenase FCM34_11130 ENOG4105CD8 aminopeptidase N FCM34_11135 ENOG4105CN1 protease FCM34_11140 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FCM34_11145 ENOG4108ZGC gaf domain protein FCM34_11160 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FCM34_11175 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) FCM34_11185 ENOG4105C59 p-type ATPase FCM34_11200 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FCM34_11205 ENOG4105Q9Y Universal stress protein FCM34_11210 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FCM34_11225 ENOG4108K3A Glutathione S-transferase FCM34_11230 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FCM34_11235 ENOG4105C2J ABC transporter FCM34_11240 ENOG4105CNN ABC, transporter FCM34_11245 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FCM34_11250 ENOG4108RVA ribokinase FCM34_11255 ENOG4105ETE Transcriptional regulator (LacI family FCM34_11275 ENOG4105F5W AtP-binding protein FCM34_11395 ENOG4108KTG Membrane protein, drug metabolite transporter FCM34_11415 ENOG4105D7V transposase FCM34_11430 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FCM34_11445 ENOG4105BZU Histidine kinase FCM34_11450 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FCM34_11455 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FCM34_11460 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FCM34_11465 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FCM34_11470 ENOG41083UC 50s ribosomal protein L35 FCM34_11475 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FCM34_11480 ENOG4105C22 threonyL-tRNA synthetase FCM34_11500 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FCM34_11505 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FCM34_11510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FCM34_11515 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FCM34_11520 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FCM34_11525 ENOG4105XPH Ferredoxin FCM34_11530 ENOG4105CA3 membrane-bound lytic murein transglycosylase FCM34_11535 ENOG4105XZD Fe-S protein FCM34_11540 ENOG4105DM4 PTS System FCM34_11545 ENOG4105DE4 1-phosphofructokinase FCM34_11550 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FCM34_11555 ENOG4107B7Y DNA-binding transcriptional regulator FruR FCM34_11560 ENOG4105E0U tyrosine-specific transport protein FCM34_11575 ENOG4105C1J atp-dependent rna helicase FCM34_11585 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FCM34_11590 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FCM34_11595 ENOG4108DG9 Smr protein MutS2 FCM34_11630 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FCM34_11690 ENOG4105K6T rare lipoprotein A FCM34_11695 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FCM34_11700 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FCM34_11705 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FCM34_11710 ENOG4106371 Methyltransferase FCM34_11715 ENOG4107S90 membrAne FCM34_11725 ENOG4105CTQ phosphohexokinase FCM34_11745 ENOG4105CH2 amidohydrolase FCM34_11755 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FCM34_11795 ENOG4105CPB ATP-dependent endonuclease of the OLD family FCM34_11810 ENOG4105VP0 transcriptional regulator, lysR family FCM34_11815 ENOG4105EJ9 Membrane FCM34_11820 ENOG4106IUH DTW domain containing protein FCM34_11825 ENOG4105CPF Cell wall formation (By similarity) FCM34_11840 ENOG4105C1J atp-dependent rna helicase FCM34_11875 ENOG41061CK Antibiotic biosynthesis monooxygenase FCM34_11880 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FCM34_11900 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FCM34_11910 ENOG4105WQ3 Rna-binding protein FCM34_11930 ENOG4105BZ1 (ABC) transporter FCM34_11935 ENOG4105BZ1 (ABC) transporter FCM34_11940 ENOG4105BZU Histidine kinase FCM34_11945 ENOG4105K63 Thioredoxin FCM34_11950 ENOG4105C8P )-transporter FCM34_11960 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FCM34_11985 ENOG4105CRQ synthase (Component I) FCM34_11995 ENOG4105C44 Serine transporter FCM34_12000 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FCM34_12005 ENOG4105C9U ATP-dependent DNA helicase RecQ FCM34_12010 ENOG4105CYN Serine protein kinase FCM34_12015 ENOG4106AKX UPF0229 protein FCM34_12020 ENOG4105ED1 spovr family FCM34_12025 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FCM34_12030 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FCM34_12035 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FCM34_12040 ENOG4105DQR SNARE associated Golgi FCM34_12050 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FCM34_12065 ENOG4105D0C transport protein FCM34_12070 ENOG4105E4C Lytic transglycosylase catalytic FCM34_12090 ENOG4108MRH transcriptional regulatory protein FCM34_12100 ENOG4105E2R ROK family FCM34_12105 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_12115 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FCM34_12120 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FCM34_12125 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FCM34_12150 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit FCM34_12155 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FCM34_12160 ENOG4105DVI reductase, NrfD FCM34_12165 ENOG4105DA4 cytochrome c-type biogenesis protein FCM34_12170 ENOG4107QX9 Thiol disulfide interChange protein FCM34_12175 ENOG4108DMF Cytochrome C biogenesis protein FCM34_12180 ENOG41061WM D-Alanyl-D-Alanine FCM34_12190 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FCM34_12195 ENOG4105MWK D-amino acid dehydrogenase, small subunit FCM34_12210 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FCM34_12220 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FCM34_12225 ENOG4105DZ2 Transcriptional regulator FCM34_12235 ENOG4105E0K tonB-dependent siderophore receptor FCM34_12240 ENOG4105BZU Histidine kinase FCM34_12245 ENOG4105BZU Histidine kinase FCM34_12250 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FCM34_12255 ENOG4105CR8 Transcriptional regulator FCM34_12260 ENOG4108RYK Nad-dependent epimerase dehydratase FCM34_12275 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FCM34_12305 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FCM34_12315 ENOG4105CGY Dna recombination protein FCM34_12370 ENOG4108NVR Methyl-accepting chemotaxis FCM34_12400 ENOG4106F1P AAA ATPase, central domain protein FCM34_12470 ENOG4105P8Q Curli production assembly transport component CsgG FCM34_12480 ENOG4108XDW curli assembly protein CsgE FCM34_12485 ENOG41086KC Transcriptional regulator FCM34_12500 ENOG4105F2I Transposase FCM34_12575 ENOG4105CAF HipA N-terminal domain protein FCM34_12590 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FCM34_12600 ENOG4105E98 transcriptional regulator DeoR family FCM34_12615 ENOG4108UGV hypoxanthine phosphoribosyltransferase FCM34_12625 ENOG4108RMJ sensory transduction regulator FCM34_12635 ENOG4107104 thymidine kinase FCM34_12640 ENOG4107S6Z Na H antiporter FCM34_12650 ENOG4108WBT adenosyltransferase FCM34_12655 ENOG4105VRT cytoplasmic protein FCM34_12660 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FCM34_12665 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FCM34_12680 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FCM34_12685 ENOG4105CFV Tetratricopeptide repeat protein FCM34_12695 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FCM34_12700 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FCM34_12705 ENOG4105CAT Cytidine monophosphate kinase FCM34_12710 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FCM34_12715 ENOG4105DUM transcriptional regulator, lysR family FCM34_12720 ENOG4105D2S major facilitator superfamily FCM34_12735 ENOG4108DBC nitroreductase FCM34_12740 ENOG4105CFC Transporter FCM34_12745 ENOG4105BZU Histidine kinase FCM34_12755 ENOG4105CBN LysR family transcriptional regulator FCM34_12760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FCM34_12785 ENOG4107RGM aldo keto reductase FCM34_12790 ENOG4105VFU Rna-binding protein FCM34_12800 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FCM34_12810 ENOG4105HA9 of methanol dehydrogenase type FCM34_12830 ENOG4108J1Q FCM34_12835 ENOG4105E14 MotA TolQ exbB proton channel FCM34_12840 ENOG4105ER2 Ompa motb domain protein FCM34_12845 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FCM34_12850 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FCM34_12855 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FCM34_12860 ENOG4105GKE subunit e FCM34_12865 ENOG4107QIZ NADH dehydrogenase FCM34_12870 ENOG4108IEH NADH dehydrogenase subunit g FCM34_12875 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FCM34_12880 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FCM34_12885 ENOG4107UFS subunit j FCM34_12890 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FCM34_12895 ENOG4105D65 subunit l FCM34_12900 ENOG4105C8S subunit m FCM34_12905 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FCM34_12915 ENOG4107QIK phosphoribosylformylglycinamidine synthase FCM34_12920 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FCM34_12925 ENOG4105VPD cellular component movement FCM34_12930 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FCM34_12935 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FCM34_12940 ENOG4105N21 Membrane FCM34_12945 ENOG4105CUT histidyl-tRNA synthetase FCM34_12950 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FCM34_12955 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FCM34_12965 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FCM34_12970 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FCM34_12975 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FCM34_12980 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FCM34_12985 ENOG4108ZIT Ferredoxin, 2FE-2S FCM34_12990 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FCM34_12995 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FCM34_13000 ENOG4108Z4V iron-sulfur cluster assembly FCM34_13005 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FCM34_13010 ENOG4105C3J Cysteine desulfurase FCM34_13015 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FCM34_13020 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FCM34_13025 ENOG4105XPQ lipid carrier protein FCM34_13030 ENOG4105CFP Peptidase U32 FCM34_13035 ENOG4106RZ4 Peptidase U32 FCM34_13050 ENOG4105KHC sulfurtransferase FCM34_13055 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FCM34_13060 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FCM34_13065 ENOG4105VIE preprotein translocase, subunit YajC FCM34_13070 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FCM34_13075 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FCM34_13080 ENOG4105W87 Cbs domain FCM34_13085 ENOG4105D3R alkyl hydroperoxide reductase FCM34_13095 ENOG4108ISG Major Facilitator FCM34_13105 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FCM34_13115 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FCM34_13120 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FCM34_13125 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FCM34_13130 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FCM34_13135 ENOG4105D0A hydroxylase FCM34_13145 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FCM34_13155 ENOG4105E5M Multidrug resistance protein D FCM34_13160 ENOG4105C3U ABC transporter FCM34_13165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FCM34_13170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FCM34_13180 ENOG4105CYM Glutathione S-transferase FCM34_13185 ENOG4108K3A Glutathione S-transferase FCM34_13200 ENOG4105EIY sodium-type flagellar protein motY FCM34_13210 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FCM34_13215 ENOG4105D3Y Na H antiporter FCM34_13225 ENOG4105CC0 LysR family Transcriptional regulator FCM34_13245 ENOG4105KA0 thioesterase Superfamily protein FCM34_13255 ENOG4105CQB FAD linked oxidase domain protein FCM34_13270 ENOG4105EE5 Membrane protein terC FCM34_13275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FCM34_13285 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FCM34_13290 ENOG4105D4U had-superfamily hydrolase, subfamily iia FCM34_13300 ENOG4105CAQ asparagine synthetase FCM34_13315 ENOG4108RXX maleylacetoacetate isomerase FCM34_13325 ENOG4105F1J Homogentisate 1,2-dioxygenase FCM34_13330 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FCM34_13340 ENOG4108W1A pseudouridine synthase FCM34_13345 ENOG4105BZU Histidine kinase FCM34_13350 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FCM34_13355 ENOG4105CR4 methylisocitrate lyase FCM34_13360 ENOG4105BZN citrate synthase FCM34_13365 ENOG4108I0Z Aconitate hydratase FCM34_13370 ENOG4105C7F AcnD-accessory protein PrpF FCM34_13380 ENOG4105CNM Receptor FCM34_13390 ENOG4108MN8 Membrane FCM34_13395 ENOG4105EM2 membrane FCM34_13400 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FCM34_13405 ENOG4108S3P Sporulation domain protein FCM34_13410 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FCM34_13415 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FCM34_13420 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FCM34_13430 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FCM34_13435 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FCM34_13445 ENOG4105D01 (LipO)protein FCM34_13465 ENOG4105DKW ABC transporter FCM34_13470 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FCM34_13475 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FCM34_13485 ENOG4105C85 amino acid FCM34_13545 ENOG4105C42 Type I secretion membrane fusion protein (HlyD FCM34_13555 ENOG4105N5T Radical SAM Protein FCM34_13560 ENOG4105CBC glutamate synthase FCM34_13565 ENOG4105BZ8 glutamate synthase FCM34_13595 ENOG4105C1J atp-dependent rna helicase FCM34_13615 ENOG4107QS8 (LipO)protein FCM34_13620 ENOG4106TD9 Diguanylate cyclase FCM34_13625 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FCM34_13630 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FCM34_13635 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FCM34_13640 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FCM34_13650 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FCM34_13655 ENOG4105E66 phosphoriboisomerase A FCM34_13660 ENOG4108JQ1 Dehydrogenase FCM34_13665 ENOG41080IJ Diacylglycerol kinase FCM34_13670 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FCM34_13675 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FCM34_13695 ENOG4105CZX twitching motility protein FCM34_13705 ENOG4105CE1 Ferrous iron transport protein b FCM34_13715 ENOG4108ZJT translation initiation factor, Sui1 FCM34_13755 ENOG410620I Diguanylate cyclase FCM34_13760 ENOG4105F2I Transposase FCM34_13795 ENOG4105C8N cysteinyl-tRNA synthetase FCM34_13800 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FCM34_13810 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FCM34_13815 ENOG4105Y3U Transglycosylase-associated protein FCM34_13820 ENOG4108WUH Transcriptional regulator, TetR family FCM34_13825 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FCM34_13835 ENOG4108J1Q FCM34_13840 ENOG4107SDU Methyl-accepting chemotaxis FCM34_13865 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FCM34_13870 ENOG4105WH1 Two component transcriptional regulator luxr family FCM34_13875 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FCM34_13880 ENOG4105W49 UPF0434 protein FCM34_13885 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FCM34_13890 ENOG4105BZ1 (ABC) transporter FCM34_13895 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FCM34_13910 ENOG4105D7A ATP-binding protein FCM34_13920 ENOG4105CGF Aromatic amino acid aminotransferase FCM34_13935 ENOG4105DVT helicase FCM34_13945 ENOG4105DGU Histone deacetylase FCM34_13950 ENOG4108ISG Major Facilitator FCM34_13955 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FCM34_13960 ENOG4105G6Z alkaline phosphatase FCM34_13980 ENOG4105NXH GreA GreB family elongation factor FCM34_13985 ENOG4105BZU Histidine kinase FCM34_13990 ENOG4106TNF Periplasmic binding protein FCM34_13995 ENOG4105E5Q amino acid AbC transporter FCM34_14000 ENOG4105CDA abc transporter atp-binding protein FCM34_14015 ENOG4105D5Q Arginine ornithine antiporter FCM34_14020 ENOG4105C3R Methionine synthase FCM34_14030 ENOG4105C37 (CBS) domain FCM34_14040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FCM34_14045 ENOG4105E2Z phosphate ABC transporter (Permease FCM34_14050 ENOG4105C8U phosphate abc transporter FCM34_14055 ENOG4108Z6B deaminase FCM34_14065 ENOG4107QP3 malate synthase g FCM34_14070 ENOG4108I9X Isocitrate lyase FCM34_14085 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FCM34_14090 ENOG4105CXB phosphoribosylaminoimidazole synthetase FCM34_14095 ENOG4108V3E phosphoribosylglycinamide formyltransferase FCM34_14100 ENOG4107QNR UPF0135 protein FCM34_14105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_14110 ENOG4105BZU Histidine kinase FCM34_14115 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_14125 ENOG4105RH4 Glycine cleavage system transcriptional repressor FCM34_14130 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FCM34_14135 ENOG4105C9X ppx gppa phosphatase FCM34_14145 ENOG4105D7V transposase FCM34_14155 ENOG4105CJW magnesium transporter FCM34_14180 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FCM34_14185 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FCM34_14190 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FCM34_14195 ENOG4105CGA flagellar basal-body rod protein FlgG FCM34_14200 ENOG4108KPB Flagellar basal-body rod protein FlgF FCM34_14205 ENOG4105BZE flagellar hook protein, FlgE FCM34_14215 ENOG4108ZC9 flagellar basal-body rod protein flgc FCM34_14220 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FCM34_14225 ENOG4105BZU Histidine kinase FCM34_14230 ENOG4107R88 Chemotaxis protein (CheV) FCM34_14235 ENOG4107ESN Flagella basal body P-ring formation protein flgA FCM34_14250 ENOG4108RE9 Phosphodiesterase FCM34_14255 ENOG4107QSI ABC, transporter FCM34_14265 ENOG4105I08 Pseudouridine synthase FCM34_14270 ENOG4105DHT Metal Dependent Phosphohydrolase FCM34_14275 ENOG4108594 Permease of the drug metabolite transporter FCM34_14305 ENOG4105VEQ Cold shock protein FCM34_14310 ENOG4107QSN dihydrolipoamide acetyltransferase FCM34_14315 ENOG4105CPP Dehydrogenase, E1 component FCM34_14320 ENOG4107RUY (E1 component), alpha subunit FCM34_14335 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) FCM34_14345 ENOG4108YXG UPF0502 protein FCM34_14375 ENOG4105E3R (LipO)protein FCM34_14395 ENOG4105D75 Capsular exopolysaccharide family FCM34_14415 ENOG4107T8Q Glycosyl transferase (Group 1 FCM34_14460 ENOG4105J5G Transferase hexapeptide repeat containing protein FCM34_14470 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FCM34_14480 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FCM34_14485 ENOG4105C1B dTDP-glucose 4-6-dehydratase FCM34_14490 ENOG4105ESV Glycosyl transferase, family 4 FCM34_14495 ENOG4105EQR Transposase IS116 IS110 IS902 FCM34_14510 ENOG4105D70 Integrase catalytic subunit FCM34_14515 ENOG4105F5W AtP-binding protein FCM34_14525 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FCM34_14535 ENOG4106KNT transcriptional regulator FCM34_14540 ENOG4105CA9 Pyruvate kinase FCM34_14550 ENOG4105BZS acriflavin resistance protein FCM34_14555 ENOG4107QPN acyl-Coa dehydrogenase FCM34_14565 ENOG4107SSZ Phosphatase FCM34_14645 ENOG4105F5W AtP-binding protein FCM34_14670 ENOG4105DZ2 Transcriptional regulator FCM34_14675 ENOG4108UZX fmn reductase FCM34_14700 ENOG4105W5Q DNA repair protein (RadC FCM34_14755 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FCM34_14760 ENOG4105BZS acriflavin resistance protein FCM34_14765 ENOG4105C1P efflux transporter, rnd family, mfp subunit FCM34_14770 ENOG4108IG5 Transcriptional regulator FCM34_14785 ENOG4105C29 acyl-CoA thioesterase FCM34_14795 ENOG4105FE9 pseudouridine synthase FCM34_14800 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FCM34_14810 ENOG4107RTD sua5 ycio yrdc ywlc family protein FCM34_14815 ENOG4105DB7 PHP domain protein FCM34_14820 ENOG4105CRQ synthase (Component I) FCM34_14825 ENOG4108EFP Anthranilate synthase component II FCM34_14830 ENOG4108I0Q anthranilate phosphoribosyltransferase FCM34_14835 ENOG4105DK0 Indole-3-glycerol phosphate synthase FCM34_14840 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FCM34_14845 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FCM34_14855 ENOG4105I03 Flagellin FCM34_14910 ENOG4105CC0 LysR family Transcriptional regulator FCM34_14920 ENOG4106FTQ Taurine ABC transporter, periplasmic FCM34_14925 ENOG4108ETV ABC transporter FCM34_14930 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FCM34_14935 ENOG4105E2B Taurine dioxygenase FCM34_14940 ENOG4105KCV RNA signal recognition particle 4.5S RNA FCM34_14945 ENOG4107RDB Major Facilitator FCM34_14950 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FCM34_14955 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FCM34_14960 ENOG4105CCU oxidase (Subunit III) FCM34_14965 ENOG4105BZ9 Cytochrome C oxidase, subunit I FCM34_14970 ENOG4105E2S oxidase) subunit II FCM34_14975 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FCM34_14980 ENOG4105CC0 LysR family Transcriptional regulator FCM34_15000 ENOG4105NTK Transcriptional repressor Mpra FCM34_15015 ENOG41090JD Blue (Type 1) copper domain protein FCM34_15040 ENOG4105CGK Exodeoxyribonuclease III FCM34_15050 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FCM34_15055 ENOG4108IJF Heavy metal efflux pump, CzcA FCM34_15070 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FCM34_15075 ENOG4105BZU Histidine kinase FCM34_15090 ENOG4105KFG YeeE YedE family protein FCM34_15100 ENOG41080HT Transcriptional regulator, arsr family FCM34_15110 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase FCM34_15125 ENOG4105WBN Transcriptional regulator (LacI family FCM34_15140 ENOG4105D7K pfkb domain protein FCM34_15150 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FCM34_15155 ENOG4105CFG Acts as a chaperone (By similarity) FCM34_15160 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FCM34_15165 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FCM34_15170 ENOG4105BZU Histidine kinase FCM34_15175 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FCM34_15185 ENOG4105DJY efflux transporter, rnd family, mfp subunit FCM34_15190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FCM34_15195 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FCM34_15200 ENOG4105Q26 Siderophore-interacting protein FCM34_15215 ENOG4105W8I Transcriptional regulator FCM34_15220 ENOG4105BZC d-serine deaminase FCM34_15230 ENOG4108HMX isocitrate dehydrogenase (NADP) FCM34_15260 ENOG4108W0I acetyltransferase FCM34_15265 ENOG4108R99 pseudouridine synthase FCM34_15275 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FCM34_15280 ENOG41075W9 High frequency lysogenization protein HflD homolog FCM34_15285 ENOG4107QTF adenylosuccinate lyase FCM34_15290 ENOG4105EZE Cupin 4 family protein FCM34_15295 ENOG4105CA9 Pyruvate kinase FCM34_15300 ENOG4105EGS Mechanosensitive ion channel FCM34_15320 ENOG4105C2W permease FCM34_15330 ENOG4107R1I NAD-dependent malic enzyme FCM34_15335 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FCM34_15340 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FCM34_15345 ENOG4105DR8 Membrane FCM34_15350 ENOG4108ESY Metal dependent phosphohydrolase FCM34_15360 ENOG4107SDU Methyl-accepting chemotaxis FCM34_15380 ENOG4105E18 UPF0276 protein FCM34_15390 ENOG4105C94 Transporter FCM34_15405 ENOG4105F2I Transposase FCM34_15420 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein FCM34_15425 ENOG4105D98 threonine synthase FCM34_15430 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FCM34_15445 ENOG4106FVC RNA methyltransferase FCM34_15450 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FCM34_15465 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FCM34_15475 ENOG41065U4 response regulator FCM34_15490 ENOG4108JJ9 ABC, transporter FCM34_15495 ENOG4108JJ8 (ABC) transporter FCM34_15515 ENOG4108R96 Methyltransferase, YaeB family FCM34_15530 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FCM34_15535 ENOG4105C6T cysteine synthase FCM34_15540 ENOG4105KZ7 phosphocarrier protein hpr FCM34_15550 ENOG4105C5Y PTS System FCM34_15555 ENOG4105CPW cytochrome b561 FCM34_15560 ENOG4105EYH Exonuclease FCM34_15565 ENOG4107RH8 nuclease SbcCD subunit D FCM34_15570 ENOG4105WCN acetyltransferase FCM34_15575 ENOG4105DH7 May be involved in recombination (By similarity) FCM34_15585 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FCM34_15590 ENOG4105CKD glutathione-regulated potassium-efflux system protein FCM34_15595 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_15625 ENOG4105CJP fad dependent oxidoreductase FCM34_15630 ENOG4107VRI Transcriptional regulator FCM34_15635 ENOG4105C26 Dehydrogenase FCM34_15640 ENOG4108JPW Aminotransferase FCM34_15645 ENOG4105CUB amino acid FCM34_15650 ENOG4105CUB amino acid FCM34_15665 ENOG4108V1T peptidylprolyl cis-trans isomerase FCM34_15670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FCM34_15680 ENOG4105XIQ Protein of unknown function (DUF2517) FCM34_15700 ENOG4105BZU Histidine kinase FCM34_15710 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FCM34_15725 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FCM34_15730 ENOG4107TT5 NLP P60 protein FCM34_15735 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FCM34_15740 ENOG4107QR8 Thioredoxin FCM34_15750 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FCM34_15755 ENOG4105CIY formyltetrahydrofolate deformylase FCM34_15780 ENOG4105E4C Lytic transglycosylase catalytic FCM34_15790 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FCM34_15795 ENOG4105EP9 oxidoreductase FCM34_15865 ENOG4105CCT upf0313 protein FCM34_15870 ENOG4105BZS acriflavin resistance protein FCM34_15880 ENOG4105BZU Histidine kinase FCM34_15885 ENOG4105D78 K07001 NTE family protein FCM34_15890 ENOG4105C8J )-transporter FCM34_15905 ENOG4105UYK outer membrane protein a FCM34_15915 ENOG4105UYK outer membrane protein a FCM34_15920 ENOG4107R1I NAD-dependent malic enzyme FCM34_15925 ENOG41075H3 AraC family transcriptional regulator FCM34_15930 ENOG4107QI1 Mate efflux family protein FCM34_15935 ENOG4105RKX Protein of unknown function (DUF2498) FCM34_15940 ENOG4105BZU Histidine kinase FCM34_15945 ENOG4105C2W permease FCM34_15950 ENOG4108KMH lipoate-protein ligase a FCM34_15955 ENOG4105BZG amino acid carrier protein FCM34_15975 ENOG4105PTV Nudix Hydrolase FCM34_15985 ENOG4105CDA abc transporter atp-binding protein FCM34_15990 ENOG4105DRP amino acid AbC transporter FCM34_15995 ENOG4105EZ7 amino acid ABC transporter FCM34_16015 ENOG4105CJ1 ABC, transporter FCM34_16020 ENOG4108V1T peptidylprolyl cis-trans isomerase FCM34_16035 ENOG4106N3A copper homeostasis protein cutc FCM34_16040 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FCM34_16050 ENOG4105ERG peptidase m48, ste24p FCM34_16060 ENOG4105BZU Histidine kinase FCM34_16065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FCM34_16070 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FCM34_16075 ENOG4105BZU Histidine kinase FCM34_16085 ENOG4105C26 Dehydrogenase FCM34_16095 ENOG4108IPJ Membrane FCM34_16105 ENOG4105CPC Aldo Keto reductase FCM34_16115 ENOG4106YYS transcriptional regulatory protein FCM34_16120 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FCM34_16130 ENOG4105J12 Multidrug resistance protein mdtN FCM34_16155 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FCM34_16160 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FCM34_16175 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FCM34_16180 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FCM34_16185 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FCM34_16190 ENOG4105EXN Sulfate transport protein CysZ FCM34_16195 ENOG4105EN6 Membrane FCM34_16205 ENOG4105EAQ (twin-arginine translocation) pathway signal FCM34_16210 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FCM34_16240 ENOG4107T9C Alpha amylase catalytic region FCM34_16250 ENOG4108W5X Transcriptional Regulator, LuxR family FCM34_16280 ENOG4105BZU Histidine kinase FCM34_16285 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FCM34_16290 ENOG4105C9K Endothelin-converting enzyme 1 FCM34_16300 ENOG4105C5H ABC transporter FCM34_16305 ENOG4105KNA -acetyltransferase FCM34_16310 ENOG4105DVH amino acid FCM34_16315 ENOG4105C44 Serine transporter FCM34_16320 ENOG4105EQ2 LysR family Transcriptional regulator FCM34_16330 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FCM34_16335 ENOG4105C0B DNA polymerase III (alpha subunit) FCM34_16340 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FCM34_16345 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FCM34_16350 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FCM34_16355 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FCM34_16360 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FCM34_16365 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FCM34_16375 ENOG4105DZP Membrane-associated zinc metalloprotease FCM34_16380 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FCM34_16385 ENOG4105KNE Phosphatidate cytidylyltransferase FCM34_16390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FCM34_16395 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FCM34_16400 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FCM34_16405 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FCM34_16410 ENOG4105CE9 30S ribosomal protein S2 FCM34_16415 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FCM34_16420 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FCM34_16425 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FCM34_16430 ENOG4108T8E UPF0325 protein FCM34_16435 ENOG4105CI1 PTS System FCM34_16440 ENOG4107W52 maltose operon periplasmic protein FCM34_16445 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FCM34_16450 ENOG4105QDK Flavodoxin FCM34_16455 ENOG4105DR9 pseudouridine synthase FCM34_16460 ENOG4105WP7 tRNA pseudouridine synthase C FCM34_16485 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein FCM34_16490 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FCM34_16495 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FCM34_16505 ENOG4105BZU Histidine kinase FCM34_16510 ENOG4105EWT decarboxylase family FCM34_16515 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FCM34_16520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FCM34_16530 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FCM34_16545 ENOG4105ETT transcriptional Regulator, LysR family FCM34_16550 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_16555 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FCM34_16570 ENOG4105CJ2 (LipO)protein FCM34_16575 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FCM34_16580 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_16585 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_16590 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_16595 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_16600 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FCM34_16605 ENOG4105M85 Bola protein FCM34_16610 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FCM34_16620 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FCM34_16630 ENOG4105EYM Major Facilitator superfamily FCM34_16635 ENOG4105DRB nucleoside-specific channel-forming protein FCM34_16640 ENOG4108VPT UPF0234 protein FCM34_16645 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FCM34_16650 ENOG4107S0N DJ-1 family FCM34_16655 ENOG4105CHH sulfate transporter FCM34_16660 ENOG4105BZU Histidine kinase FCM34_16665 ENOG4105E3W Two component transcriptional regulator (Winged helix family FCM34_16670 ENOG4105C1P efflux transporter, rnd family, mfp subunit FCM34_16675 ENOG4105BZS acriflavin resistance protein FCM34_16690 ENOG4105CMR udp-glucose 4-epimerase FCM34_16700 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FCM34_16705 ENOG4108RMU ferritin dps family protein FCM34_16730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FCM34_16745 ENOG4105EMU Dehydrogenase FCM34_16755 ENOG4105CVP deoxyribo-dipyrimidine photolyase FCM34_16760 ENOG4108XDN Transcriptional regulator FCM34_16765 ENOG4107SEY Conserved Protein FCM34_16790 ENOG4105CQC Prephenate dehydratase FCM34_16820 ENOG4105D8V Glucose sorbosone dehydrogenase FCM34_16830 ENOG4105MVE transcriptional regulator FCM34_16840 ENOG4105G63 Type III effector Hrp-dependent FCM34_16845 ENOG4105FB2 class II Aldolase FCM34_16850 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FCM34_16855 ENOG4105EXW epimerase dehydratase FCM34_16860 ENOG4105C6Z Gluconate FCM34_16870 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_16885 ENOG4105E1F short-chain dehydrogenase reductase FCM34_16895 ENOG4105YES addiction module antidote protein FCM34_16970 ENOG4108C33 Resolvase FCM34_17005 ENOG4105CTD carboxy-peptidase FCM34_17025 ENOG4105XDF Protein of unknown function (DUF1272) FCM34_17035 ENOG4105CFP Peptidase U32 FCM34_17040 ENOG4105N14 lysine exporter protein LysE YggA FCM34_17050 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FCM34_17085 ENOG4105DB1 molybdopterin oxidoreductase FCM34_17090 ENOG4106WHD Tetrathionate reductase FCM34_17095 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FCM34_17100 ENOG4105BZU Histidine kinase FCM34_17105 ENOG4108ZXC Two component transcriptional regulator, luxr family FCM34_17110 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) FCM34_17115 ENOG4105C0R drug resistance transporter emrb qaca subfamily FCM34_17120 ENOG4105CW7 secretion protein, HlyD family FCM34_17150 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FCM34_17155 ENOG4105CDU Replicative dna helicase FCM34_17165 ENOG4105CGH 5'-nucleotidase FCM34_17185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_17190 ENOG4108V1T peptidylprolyl cis-trans isomerase FCM34_17200 ENOG4105VRX Protein slyX homolog FCM34_17205 ENOG4108YZY peptidylprolyl cis-trans isomerase FCM34_17210 ENOG4105VKU nucleicacid-binding protein FCM34_17220 ENOG4107R88 Chemotaxis protein (CheV) FCM34_17225 ENOG4105DNZ Alpha Beta Hydrolase FCM34_17235 ENOG4105YP7 UPF0270 protein FCM34_17240 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FCM34_17255 ENOG4108UKZ OsmC family FCM34_17260 ENOG4107RYR Transcriptional regulator, Crp Fnr family FCM34_17265 ENOG4105DHI Methyltransferase FCM34_17275 ENOG4105BZU Histidine kinase FCM34_17280 ENOG4105D8G Major Facilitator superfamily FCM34_17305 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related FCM34_17310 ENOG41090JE Utilization Protein FCM34_17320 ENOG4105EHG Permease protein FCM34_17335 ENOG4105C6Y Udp-glucose 6-dehydrogenase FCM34_17345 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FCM34_17355 ENOG4105CKK Glycosyl transferase, family 2 FCM34_17360 ENOG4105E4C Lytic transglycosylase catalytic FCM34_17365 ENOG4105C5H ABC transporter FCM34_17375 ENOG4105C7N Xanthine uracil vitamin C permease FCM34_17385 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FCM34_17390 ENOG4108S0S Nucleotidyl transferase FCM34_17395 ENOG4105EHM Aminoglycoside phosphotransferase FCM34_17400 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FCM34_17410 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FCM34_17415 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FCM34_17420 ENOG4105NWN ApaG protein FCM34_17425 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FCM34_17435 ENOG4105DEN Luciferase family FCM34_17445 ENOG4105DWD nucleoside recognition domain protein FCM34_17450 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FCM34_17455 ENOG4105K46 50S ribosomal protein l27 FCM34_17460 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FCM34_17465 ENOG4105EAH synthase FCM34_17475 ENOG4105EPW hflc protein FCM34_17480 ENOG4107QJR hflk protein FCM34_17485 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FCM34_17490 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FCM34_17495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FCM34_17500 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FCM34_17505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FCM34_17510 ENOG4105K8N protein family UPF0079, ATPase FCM34_17515 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FCM34_17535 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FCM34_17540 ENOG4108UMI ABC transporter, permease FCM34_17545 ENOG4105D01 (LipO)protein FCM34_17550 ENOG4105MDZ Transcriptional activator rfaH FCM34_17555 ENOG4107SDU Methyl-accepting chemotaxis FCM34_17560 ENOG4105BZU Histidine kinase FCM34_17565 ENOG4105BZU Histidine kinase FCM34_17580 ENOG4105BZU Histidine kinase FCM34_17600 ENOG4108Q67 UPF0319 protein FCM34_17605 ENOG4105EXG Transcriptional regulator FCM34_17615 ENOG4107QWK SAICAR synthetase FCM34_17620 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FCM34_17625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FCM34_17630 ENOG4105RH4 Glycine cleavage system transcriptional repressor FCM34_17635 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FCM34_17640 ENOG4105XWI UPF0304 protein FCM34_17650 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FCM34_17655 ENOG4105C6K Malic enzyme FCM34_17660 ENOG4108ZP8 Acetolactate synthase small subunit FCM34_17665 ENOG4105C7K acetolactate synthase FCM34_17690 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FCM34_17700 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FCM34_17705 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FCM34_17720 ENOG4105DP9 ABC transporter FCM34_17725 ENOG4106SMU thiamine transporter membrane protein FCM34_17730 ENOG4107T0D ABC, transporter FCM34_17735 ENOG4108IAB Phoh family FCM34_17745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FCM34_17775 ENOG4107QWG 2-Nitropropane dioxygenase FCM34_17800 ENOG4105E0F Histidine kinase FCM34_17805 ENOG4105E3W Two component transcriptional regulator (Winged helix family FCM34_17810 ENOG4105DJY efflux transporter, rnd family, mfp subunit FCM34_17815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FCM34_17825 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase FCM34_17845 ENOG4106B0W Curli production assembly transport component CsgG FCM34_17855 ENOG4107Y60 (LipO)protein FCM34_17860 ENOG4105BZU Histidine kinase FCM34_17865 ENOG4105C1J atp-dependent rna helicase FCM34_17875 ENOG4106AXJ AraC family transcriptional regulator FCM34_17910 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FCM34_17915 ENOG4105DWY Agmatine deiminase FCM34_17930 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FCM34_17935 ENOG4108MJ3 acetyltransferase FCM34_17940 ENOG4105C09 Bile acid FCM34_17955 ENOG4105BZU Histidine kinase FCM34_17960 ENOG4105BZU Histidine kinase FCM34_17965 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FCM34_17980 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FCM34_17990 ENOG4108IQE Amp-dependent synthetase and ligase FCM34_18015 ENOG4107SQD Transcriptional regulator, GntR family FCM34_18030 ENOG4105C8J )-transporter FCM34_18035 ENOG4105C8J )-transporter FCM34_18050 ENOG4108K4B hydrolase FCM34_18065 ENOG4105EW9 transcriptional regulator AsnC family FCM34_18080 ENOG4105K56 Transcriptional regulator FCM34_18085 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FCM34_18105 ENOG4105E0X reductase FCM34_18115 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FCM34_18120 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FCM34_18130 ENOG4105DSB aldose 1-epimerase FCM34_18135 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FCM34_18140 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_18215 ENOG4105UFD tol-pal system protein YbgF FCM34_18220 ENOG4105KCK Peptidoglycan-associated lipoprotein FCM34_18225 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FCM34_18235 ENOG4105M8F Biopolymer transport protein exbD tolR FCM34_18240 ENOG4105E02 MotA TolQ exbB proton channel FCM34_18245 ENOG4107YD3 Thioesterase FCM34_18250 ENOG4105KJB cyd operon protein YbgE FCM34_18260 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FCM34_18265 ENOG4105C4M (Ubiquinol oxidase) subunit I FCM34_18270 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FCM34_18275 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FCM34_18280 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_18285 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FCM34_18290 ENOG41083X2 DNA polymerase III, epsilon subunit FCM34_18295 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr FCM34_18310 ENOG41060WC Enoyl-CoA hydratase FCM34_18315 ENOG4106WH9 Protein of unknown function (DUF2753) FCM34_18325 ENOG4107QSI ABC, transporter FCM34_18340 ENOG4105C1J atp-dependent rna helicase FCM34_18345 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FCM34_18375 ENOG4105EJG cellulose synthase FCM34_18380 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FCM34_18385 ENOG4107EEX Cellulose synthase regulator protein FCM34_18390 ENOG4107QZ7 Cellulose synthase catalytic subunit FCM34_18410 ENOG4105CGF Aromatic amino acid aminotransferase FCM34_18425 ENOG41076CZ activating enzyme FCM34_18430 ENOG4105G0K glycine radical enzyme YjjI family FCM34_18455 ENOG4105C8Q Methyl-accepting chemotaxis FCM34_18460 ENOG4108M1A Chitin-binding protein FCM34_18465 ENOG4107R11 Transcriptional regulator FCM34_18470 ENOG4108IJ6 ABC transporter FCM34_18475 ENOG4105ECW sulfate abc transporter FCM34_18480 ENOG4108I5D sulfate abc transporter FCM34_18490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FCM34_18520 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FCM34_18525 ENOG4105D3G Pseudouridine synthase FCM34_18540 ENOG4105BZU Histidine kinase FCM34_18550 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FCM34_18555 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FCM34_18565 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FCM34_18570 ENOG4108IJ0 Aspartate ammonia-lyase FCM34_18575 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FCM34_18580 ENOG4105D9M gamma-glutamylcysteine synthetase FCM34_18590 ENOG4105W39 Membrane FCM34_18605 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FCM34_18625 ENOG4105DP0 ferredoxin-NADP reductase FCM34_18630 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FCM34_18635 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FCM34_18640 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FCM34_18645 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FCM34_18650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FCM34_18655 ENOG4107YB6 acetyltransferase, (GNAT) family FCM34_18665 ENOG4105C2N RNA methyltransferase TrmH family group 3 FCM34_18670 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FCM34_18675 ENOG4106TD9 Diguanylate cyclase FCM34_18680 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FCM34_18690 ENOG4108YZA Nitrogen regulatory protein pii FCM34_18695 ENOG4105C4K Nad synthetase FCM34_18740 ENOG4106855 Competence protein FCM34_18745 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FCM34_18750 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FCM34_18755 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FCM34_18760 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FCM34_18765 ENOG4105DTN riboflavin biosynthesis protein ribF FCM34_18770 ENOG4105CJR Integral membrane protein (MviN FCM34_18775 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FCM34_18780 ENOG41080HT Transcriptional regulator, arsr family FCM34_18785 ENOG41063Z6 transcriptional regulator, lysR family FCM34_18795 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FCM34_18800 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FCM34_18805 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FCM34_18810 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FCM34_18815 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FCM34_18830 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FCM34_18835 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FCM34_18840 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FCM34_18845 ENOG4105K5M 30s ribosomal protein S16 FCM34_18850 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FCM34_18855 ENOG4106KVJ cytochrome C assembly protein FCM34_18860 ENOG4108JU6 CBS domain protein FCM34_18875 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FCM34_18880 ENOG4108UV7 flagellar protein motX FCM34_18885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FCM34_18890 ENOG4105DMR ABC, transporter FCM34_18895 ENOG4105GBT ABC transporter FCM34_18900 ENOG4106TNF Periplasmic binding protein FCM34_18905 ENOG4105E5Z arginine transporter ATP-binding subunit FCM34_18910 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FCM34_18915 ENOG4105EZR dyp-type peroxidase family protein FCM34_18920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FCM34_18930 ENOG4107QKW extracellular solute-binding protein family 1 FCM34_18935 ENOG4108YZA Nitrogen regulatory protein pii FCM34_18940 ENOG4108YZN class I peptide chain release factor FCM34_18950 ENOG4105D9N nucleoside FCM34_18955 ENOG4105HEI LysR family (Transcriptional regulator FCM34_18970 ENOG4105BZW Glycerate kinase FCM34_18975 ENOG4107QQ0 gntp family FCM34_18980 ENOG4107VHA regulatoR FCM34_18985 ENOG4105XTV UPF0231 protein FCM34_19005 ENOG4105VZ9 UPF0235 protein FCM34_19010 ENOG4108VIA integral membrane protein FCM34_19015 ENOG4105II7 pyrroline-5-carboxylate reductase FCM34_19020 ENOG4105DFA alanine racemase domain protein FCM34_19025 ENOG4105CZX twitching motility protein FCM34_19030 ENOG4105CZX twitching motility protein FCM34_19035 ENOG4105D1Q UPF0246 protein FCM34_19040 ENOG4105C1J atp-dependent rna helicase FCM34_19045 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FCM34_19050 ENOG4105CWM branched-chain amino acid transport system II carrier protein FCM34_19065 ENOG4105MYN Zinc uptake regulation protein FCM34_19070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FCM34_19085 ENOG4105K70 DNA-binding protein FCM34_19090 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FCM34_19100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FCM34_19115 ENOG4105EAC phosphoserine phosphatase FCM34_19125 ENOG4105BZU Histidine kinase FCM34_19130 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FCM34_19135 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FCM34_19140 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FCM34_19145 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FCM34_19155 ENOG4105D9N nucleoside FCM34_19160 ENOG4105EYA deoxyribonuclease FCM34_19175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FCM34_19180 ENOG4105BZU Histidine kinase FCM34_19200 ENOG4108K5H permease YjgP YjgQ family protein FCM34_19205 ENOG4108M8S permease YjgP YjgQ family protein FCM34_19210 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FCM34_19215 ENOG4105MYG DNA polymerase iii, chi subunit FCM34_19220 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FCM34_19230 ENOG4106W5V Membrane FCM34_19235 ENOG41061WM D-Alanyl-D-Alanine FCM34_19270 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FCM34_19275 ENOG4105CFH Aspartokinase FCM34_19280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FCM34_19285 ENOG4105Y3E Modulates RecA activity (By similarity) FCM34_19290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FCM34_19295 ENOG4107TH8 cina domain protein FCM34_19310 ENOG4108NF7 phage-type endonuclease FCM34_19355 ENOG4105W5Q DNA repair protein (RadC FCM34_19400 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FCM34_19405 ENOG4105NI8 Cytosine-specific methyltransferase FCM34_19440 ENOG4105DFP Integrase FCM34_19445 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FCM34_19490 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FCM34_19495 ENOG4107ZVW dihydroneopterin aldolase FCM34_19500 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FCM34_19510 ENOG4105C0R drug resistance transporter emrb qaca subfamily FCM34_19520 ENOG4105EQR Transposase IS116 IS110 IS902 FCM34_19525 ENOG4105CKI cobalamin synthesis protein FCM34_19535 ENOG4105E82 cytochrome subunit of dehydrogenase FCM34_19545 ENOG4105BZU Histidine kinase FCM34_19550 ENOG4107QIJ Aconitate hydratase 2 FCM34_19555 ENOG4105D78 K07001 NTE family protein FCM34_19560 ENOG4108N3W hemolysin secretion protein FCM34_19565 ENOG4108N3W hemolysin secretion protein FCM34_19575 ENOG4107QN2 dihydrolipoyl dehydrogenase FCM34_19580 ENOG4107QSN dihydrolipoamide acetyltransferase FCM34_19585 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FCM34_19590 ENOG41073TP transcriptional regulator FCM34_19605 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FCM34_19610 ENOG4105F2I Transposase FCM34_19620 ENOG4107QHF type ii secretion system protein e FCM34_19625 ENOG4105D7Q type ii secretion system FCM34_19630 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FCM34_19640 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FCM34_19645 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FCM34_19650 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FCM34_19660 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FCM34_19670 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FCM34_19675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FCM34_19680 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FCM34_19685 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FCM34_19690 ENOG4105DFU Cell wall formation (By similarity) FCM34_19695 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FCM34_19700 ENOG4105CNI cell division protein FtsW FCM34_19705 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FCM34_19710 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FCM34_19715 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FCM34_19720 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FCM34_19725 ENOG4105CJN penicillin-binding protein FCM34_19730 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FCM34_19735 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FCM34_19740 ENOG4108V6E Cell division protein mraZ FCM34_19750 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FCM34_19755 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FCM34_19760 ENOG41082RQ UPF0102 protein FCM34_19765 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FCM34_19770 ENOG4105W4M Transport-associated protein FCM34_19775 ENOG4105KB2 stringent starvation protein b FCM34_19780 ENOG4107MKT Stringent starvation protein a FCM34_19785 ENOG4105EIX cytochrome c1 FCM34_19790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FCM34_19795 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FCM34_19800 ENOG4108UJD 30S ribosomal protein S9 FCM34_19805 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FCM34_19810 ENOG4105D6Z AFG1 family ATPase FCM34_19820 ENOG4105C0H protease FCM34_19825 ENOG4105C0H protease FCM34_19855 ENOG41069H0 dihydroorotase EC 3.5.2.3 FCM34_19870 ENOG4105CTS PTS system mannitol-specific FCM34_19875 ENOG41080Z8 PHOSPHOCARRIER protein FCM34_19880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FCM34_19885 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FCM34_19890 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FCM34_19895 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FCM34_19900 ENOG4108IUZ ABC transporter FCM34_19905 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FCM34_19915 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FCM34_19920 ENOG4105C2X Arabinose 5-phosphate isomerase FCM34_19925 ENOG4105DHJ ABC, transporter FCM34_19930 ENOG4105CY3 ABC transporter, permease FCM34_19935 ENOG4107PE3 Mammalian cell entry related domain protein FCM34_19940 ENOG4105E3I toluene tolerance FCM34_19950 ENOG4105VFK BolA family FCM34_19955 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FCM34_19960 ENOG4105KRS Proteinase inhibitor FCM34_19965 ENOG4105CBT Fructose-1,6-bisphosphatase FCM34_19975 ENOG4105DMQ Methyltransferase FCM34_19985 ENOG4105E0K tonB-dependent siderophore receptor FCM34_20000 ENOG4105KVH Transcriptional regulator FCM34_20005 ENOG4105N0V mono-oxygenase ydhR FCM34_20015 ENOG4108TPP exopolysaccharide synthesis FCM34_20020 ENOG4105BZU Histidine kinase FCM34_20025 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FCM34_20050 ENOG4108J1Q FCM34_20055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FCM34_20060 ENOG4105D41 biosynthesis protein thiH FCM34_20065 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FCM34_20075 ENOG4105D06 uba thif-type nad fad binding protein FCM34_20080 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FCM34_20085 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FCM34_20100 ENOG4105ETX regulatoR FCM34_20110 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FCM34_20120 ENOG4105C3R Methionine synthase FCM34_20125 ENOG4105EEQ Na H antiporter FCM34_20145 ENOG4105CGZ zinc metallopeptidase FCM34_20155 ENOG4105CSH Transporter FCM34_20170 ENOG4105D1U peptidase U62 modulator of DNA gyrase FCM34_20180 ENOG4105QD6 exported protein FCM34_20185 ENOG4105C03 ribonuclease FCM34_20190 ENOG4108Z03 MAF-like protein FCM34_20195 ENOG4105VQ7 Rod shape-determining protein MreD FCM34_20200 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FCM34_20205 ENOG4105DFF Rod shape-determining protein mreb FCM34_20250 ENOG4105D7Q type ii secretion system FCM34_20275 ENOG4105GVR general secretion pathway protein D FCM34_20310 ENOG4107XTP (EAL) domain protein FCM34_20315 ENOG4105EWV Sodium calcium exchanger membrane region FCM34_20320 ENOG4105C84 Histidine ammonia-lyase FCM34_20325 ENOG4105CGP Urocanate hydratase FCM34_20330 ENOG41088SP formiminoglutamate hydrolase FCM34_20335 ENOG4105CI2 imidazolone-5-propionate hydrolase FCM34_20340 ENOG4105CZE histidine utilization repressor FCM34_20345 ENOG41077A9 carbonic anhydrase FCM34_20350 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FCM34_20355 ENOG4105CRP Part of the ABC transporter FtsEX involved in FCM34_20360 ENOG4105CAK Cell division ATP-binding protein ftsE FCM34_20365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FCM34_20370 ENOG4106H78 methyltransferase FCM34_20380 ENOG4108Y73 Membrane FCM34_20385 ENOG4105EJ2 Transcriptional regulator FCM34_20395 ENOG4107RZC phospholipase d FCM34_20400 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FCM34_20410 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FCM34_20420 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FCM34_20425 ENOG4105VVZ metal-binding protein FCM34_20440 ENOG4105CR8 Transcriptional regulator FCM34_20455 ENOG4107FS9 Membrane FCM34_20475 ENOG4105CUG Oligopeptidase b FCM34_20490 ENOG4105EMU Dehydrogenase FCM34_20495 ENOG4106NZI LysR family Transcriptional regulator FCM34_20500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FCM34_20565 ENOG4105F5W AtP-binding protein FCM34_20580 ENOG4108ZT0 50S ribosomal protein l17 FCM34_20585 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FCM34_20590 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FCM34_20595 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FCM34_20600 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FCM34_20605 ENOG41067V7 50S ribosomal protein L36 FCM34_20610 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FCM34_20615 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FCM34_20620 ENOG4105VPB 50S ribosomal protein L30 FCM34_20625 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FCM34_20630 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FCM34_20635 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FCM34_20640 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FCM34_20645 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FCM34_20650 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FCM34_20655 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FCM34_20660 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FCM34_20665 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FCM34_20670 ENOG41083MP 50s ribosomal protein l29 FCM34_20675 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FCM34_20680 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FCM34_20685 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FCM34_20690 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FCM34_20695 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FCM34_20700 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FCM34_20705 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FCM34_20710 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FCM34_20715 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FCM34_20725 ENOG4105E0F Histidine kinase FCM34_20730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FCM34_20735 ENOG4108RRZ Transcription elongation factor GreB FCM34_20740 ENOG4105BZM domain protein FCM34_20755 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FCM34_20760 ENOG4105MJ2 Competence protein FCM34_20765 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FCM34_20770 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FCM34_20775 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FCM34_20780 ENOG4107YZP Rhodanese domain protein FCM34_20785 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FCM34_20790 ENOG41063SB peptidase FCM34_20800 ENOG4105DIQ Transcriptional regulator FCM34_20815 ENOG4108UHU Aldolase FCM34_20820 ENOG4105C01 Dihydroxy-acid dehydratase FCM34_20825 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FCM34_20830 ENOG4105C6Z Gluconate FCM34_20835 ENOG4105JIM Phosphatidylserine synthase FCM34_20840 ENOG4105CB5 ATP-dependent DNA helicase recG FCM34_20850 ENOG4105SUU thioesterase domain FCM34_20860 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FCM34_20865 ENOG4107S2Z UPF0761 membrane protein FCM34_20875 ENOG4105C5F glutamine synthetase FCM34_20885 ENOG4105CUX Signal transduction histidine kinase FCM34_20890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FCM34_20895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FCM34_20900 ENOG4105D4P Coproporphyrinogen iii oxidase FCM34_20905 ENOG4105XCT Protein of unknown function (DUF2489) FCM34_20910 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FCM34_20915 ENOG4106RE7 Cytochrome FCM34_20920 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FCM34_20925 ENOG4105E2X shikimate dehydrogenase FCM34_20930 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FCM34_20935 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FCM34_20940 ENOG4108WI1 Dna topoisomerase FCM34_20945 ENOG4108RPN Protein smg homolog FCM34_20950 ENOG4105C79 DNA protecting protein DprA FCM34_20960 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FCM34_20965 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FCM34_20970 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FCM34_20975 ENOG4105C1A potassium transporter peripheral membrane FCM34_20980 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FCM34_20985 ENOG4105CGY Dna recombination protein FCM34_21005 ENOG4108MGF sugar kinase FCM34_21010 ENOG4107R11 Transcriptional regulator FCM34_21015 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FCM34_21020 ENOG4105C26 Dehydrogenase FCM34_21030 ENOG4108JCI Transcriptional regulator FCM34_21035 ENOG4105C26 Dehydrogenase FCM34_21040 ENOG4105FR1 rard protein FCM34_21045 ENOG4105ECQ AraC Family Transcriptional Regulator FCM34_21055 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) FCM34_21075 ENOG41061EV selenium-binding protein YdfZ FCM34_21090 ENOG4105HEI LysR family (Transcriptional regulator FCM34_21095 ENOG4108UK5 Transposase FCM34_21105 ENOG4105F2I Transposase FCM34_21115 ENOG4108J1Q FCM34_21120 ENOG4105C4R Atp-dependent dna helicase FCM34_21135 ENOG4105DIH basic membrane FCM34_21140 ENOG4108JQ9 ABC transporter FCM34_21145 ENOG4105UIB (ABC) transporter FCM34_21155 ENOG4105CC0 LysR family Transcriptional regulator FCM34_21165 ENOG4105C4W S-formylglutathione hydrolase FCM34_21185 ENOG4105DHU Bile acid FCM34_21190 ENOG4105E5D amino acid FCM34_21200 ENOG4105E5D amino acid FCM34_21205 ENOG4105FK9 beta-D-galactosidase beta subunit FCM34_21210 ENOG4105CNT hydrolase family 2 FCM34_21215 ENOG4105CQ4 Transcriptional regulator FCM34_21250 ENOG4108RR8 protoporphyrinogen oxidase FCM34_21255 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FCM34_21260 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FCM34_21265 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FCM34_21270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FCM34_21275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FCM34_21280 ENOG4105CHU acetyl-coa acetyltransferase FCM34_21285 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FCM34_21290 ENOG4105E0F Histidine kinase FCM34_21295 ENOG4105T29 extracellular solute-binding protein FCM34_21305 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FCM34_21310 ENOG4105M4H endoribonuclease L-psp FCM34_21315 ENOG4108ZG0 Ompa motb domain protein FCM34_21340 ENOG4108R3E Dna-3-methyladenine glycosylase i FCM34_21345 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FCM34_21350 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FCM34_21355 ENOG4105F2I Transposase FCM34_21360 ENOG4105F2I Transposase FCM34_21380 ENOG4105CIC tryptophan-specific transport protein FCM34_21385 ENOG4105CIC tryptophan-specific transport protein FCM34_21390 ENOG4105C0F tryptophanase EC 4.1.99.1 FCM34_21400 ENOG4105HEE Binding Domain protein FCM34_21410 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FCM34_21415 ENOG4105CNW domain protein FCM34_21420 ENOG4108JUA Transcriptional regulator FCM34_21425 ENOG4105ETE Transcriptional regulator (LacI family FCM34_21430 ENOG4105CP9 extracellular ligand-binding receptor FCM34_21435 ENOG4105C32 Amino acid ABC transporter (Permease) FCM34_21440 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FCM34_21445 ENOG4105C0Z ABC transporter FCM34_21450 ENOG4108IV0 ABC, transporter FCM34_21465 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FCM34_21480 ENOG4105W0Z cytoplasmic protein FCM34_21485 ENOG4107QK7 reductase FCM34_21490 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FCM34_21500 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FCM34_21505 ENOG4105K63 Thioredoxin FCM34_21510 ENOG4105C1J atp-dependent rna helicase FCM34_21515 ENOG4105C9X ppx gppa phosphatase FCM34_21525 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FCM34_21530 ENOG4105BZU Histidine kinase FCM34_21535 ENOG4105DGW oligopeptidase A FCM34_21540 ENOG4105D52 delta-aminolevulinic acid dehydratase FCM34_21545 ENOG4105F8V Hydrolase, tatD family FCM34_21550 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FCM34_21555 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FCM34_21560 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FCM34_21565 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FCM34_21570 ENOG4105JC1 sterol-binding domain protein FCM34_21580 ENOG4105WMR Protein CrcB homolog FCM34_21585 ENOG4105DZC cytosine deaminase FCM34_21615 ENOG4108Z0R Transferase FCM34_21620 ENOG4105C2M dna polymerase I FCM34_21625 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FCM34_21630 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FCM34_21640 ENOG4105D7W serine acetyltransferase FCM34_21645 ENOG41076HS cation diffusion facilitator family transporter FCM34_21650 ENOG4105E3W Two component transcriptional regulator (Winged helix family FCM34_21655 ENOG4105E0F Histidine kinase FCM34_21660 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FCM34_21665 ENOG4107R73 Mate efflux family protein FCM34_21680 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FCM34_21685 ENOG4105E55 glycerol-3-phosphate acyltransferase FCM34_21690 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FCM34_21695 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FCM34_21700 ENOG4105X6C Flagellar basal body-associated protein FliL FCM34_21720 ENOG4105DIQ Transcriptional regulator FCM34_21765 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FCM34_21770 ENOG41062JF Transcriptional regulator FCM34_21775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FCM34_21780 ENOG4105CPQ Dehydrogenase FCM34_21785 ENOG4105MPD Cytochrome FCM34_21790 ENOG4105BZU Histidine kinase FCM34_21795 ENOG4105C4R Atp-dependent dna helicase FCM34_21800 ENOG4105C9B Cysteine desulfurase FCM34_21805 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FCM34_21810 ENOG4105CUZ uba thif-type nad fad binding protein FCM34_21845 ENOG410822N TonB family FCM34_21850 ENOG4109015 Biopolymer transport protein exbD tolR FCM34_21870 ENOG4105VJY transcriptional regulator FCM34_21875 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FCM34_21880 ENOG410804X Transcriptional regulator FCM34_21885 ENOG4105E3W Two component transcriptional regulator (Winged helix family FCM34_21890 ENOG4105EB3 Histidine kinase FCM34_21900 ENOG4105CT7 inner membrane cred family protein FCM34_21905 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FCM34_21910 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FCM34_21915 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FCM34_21920 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FCM34_21925 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FCM34_21930 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FCM34_21935 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FCM34_21940 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FCM34_21945 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FCM34_21955 ENOG4105FA0 parb-like partition protein FCM34_21960 ENOG4107QJE Chromosome Partitioning Protein FCM34_21965 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FCM34_21970 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FCM34_21975 ENOG4105QTB Flavodoxin FCM34_21980 ENOG4105E0K tonB-dependent siderophore receptor FCM34_21985 ENOG4105IBP Cyclic peptide transporter FCM34_21990 ENOG4105E0A ABC, transporter FCM34_21995 ENOG4105J76 Periplasmic binding protein FCM34_22000 ENOG4105S6R Iron-hydroxamate transporter permease subunit FCM34_22005 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FCM34_22010 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FCM34_22015 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FCM34_22020 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FCM34_22025 ENOG4105VG0 50S ribosomal protein l34 FCM34_22030 ENOG4105CDA abc transporter atp-binding protein FCM34_22035 ENOG4105E5Q amino acid AbC transporter FCM34_22040 ENOG4105EAB amino acid AbC transporter