locus-tag	class	description
WP2W18E01_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP2W18E01_00020	COG0592	DNA-directed DNA polymerase activity
WP2W18E01_00040	COG0187	DNA topoisomerase II activity
WP2W18E01_00050	COG2207	Transcriptional regulator
WP2W18E01_00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2W18E01_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18E01_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18E01_00090	COG3977	Valine--pyruvate aminotransferase
WP2W18E01_00120	COG2814	Major facilitator Superfamily
WP2W18E01_00130	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_00140	COG2205	protein histidine kinase activity
WP2W18E01_00190	COG2801	Transposase and inactivated derivatives
WP2W18E01_00240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E01_00250	COG4191	Histidine kinase
WP2W18E01_00250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_00280	COG1309	transcriptional regulator
WP2W18E01_00300	COG0561	phosphatase activity
WP2W18E01_00310	COG2267	carboxylic ester hydrolase activity
WP2W18E01_00330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18E01_00340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18E01_00350	COG1758	RNA polymerase activity
WP2W18E01_00370	COG0859	PFAM glycosyl transferase family 9
WP2W18E01_00380	COG3642	lipopolysaccharide core region biosynthetic process
WP2W18E01_00460	COG0589	response to stress
WP2W18E01_00470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP2W18E01_00480	COG3706	GGDEF domain
WP2W18E01_00490	COG1528	Iron-storage protein
WP2W18E01_00500	COG2081	HI0933 family
WP2W18E01_00510	COG2223	nitrite transmembrane transporter activity
WP2W18E01_00520	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_00530	COG2801	Transposase and inactivated derivatives
WP2W18E01_00540	COG3275	phosphorelay sensor kinase activity
WP2W18E01_00560	COG3279	Response regulator of the LytR AlgR family
WP2W18E01_00570	COG2223	nitrite transmembrane transporter activity
WP2W18E01_00580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP2W18E01_00590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP2W18E01_00640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP2W18E01_00650	COG2166	iron-sulfur cluster assembly
WP2W18E01_00660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP2W18E01_00700	COG1063	alcohol dehydrogenase
WP2W18E01_00710	COG0156	8-amino-7-oxononanoate synthase activity
WP2W18E01_00730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2W18E01_00750	COG3307	-O-antigen
WP2W18E01_00820	COG1609	Transcriptional regulator
WP2W18E01_00860	COG1580	Controls the rotational direction of flagella during chemotaxis
WP2W18E01_00870	COG3161	chorismate lyase activity
WP2W18E01_00880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP2W18E01_00890	COG2937	Belongs to the GPAT DAPAT family
WP2W18E01_00900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2W18E01_00930	COG0534	Mate efflux family protein
WP2W18E01_00940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP2W18E01_00950	COG2205	protein histidine kinase activity
WP2W18E01_00960	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_00980	COG1045	serine acetyltransferase
WP2W18E01_01000	COG3074	FtsZ-dependent cytokinesis
WP2W18E01_01010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP2W18E01_01020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18E01_01020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18E01_01030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP2W18E01_01040	COG1609	Transcriptional regulator
WP2W18E01_01050	COG3250	beta-galactosidase activity
WP2W18E01_01060	COG2731	YhcH YjgK YiaL family protein
WP2W18E01_01070	COG0531	amino acid
WP2W18E01_01080	COG3385	transposase activity
WP2W18E01_01090	COG0531	amino acid
WP2W18E01_01100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E01_01110	COG0531	amino acid
WP2W18E01_01120	COG0385	Bile acid
WP2W18E01_01130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18E01_01180	COG0583	DNA-binding transcription factor activity
WP2W18E01_01230	COG0210	DNA helicase
WP2W18E01_01250	COG1943	Transposase
WP2W18E01_01260	COG0583	DNA-binding transcription factor activity
WP2W18E01_01330	COG0583	DNA-binding transcription factor activity
WP2W18E01_01360	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_01380	COG2962	Rard protein
WP2W18E01_01400	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_01410	COG1396	sequence-specific DNA binding
WP2W18E01_01440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18E01_01440	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18E01_01460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E01_01500	COG1322	Protein conserved in bacteria
WP2W18E01_01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18E01_01520	COG0569	domain protein
WP2W18E01_01530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18E01_01530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18E01_01540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP2W18E01_01550	COG0242	peptide deformylase activity
WP2W18E01_01570	COG0758	DNA mediated transformation
WP2W18E01_01580	COG2922	Belongs to the Smg family
WP2W18E01_01590	COG0551	DNA topoisomerase type I activity
WP2W18E01_01600	COG0009	L-threonylcarbamoyladenylate synthase
WP2W18E01_01610	COG0408	coproporphyrinogen oxidase activity
WP2W18E01_01620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP2W18E01_01630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP2W18E01_01660	COG3385	transposase activity
WP2W18E01_01670	COG3078	GTPase activator activity
WP2W18E01_01690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2W18E01_01700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2W18E01_01720	COG3852	Histidine kinase
WP2W18E01_01740	COG0174	glutamine synthetase
WP2W18E01_01760	COG1295	ribonuclease BN
WP2W18E01_01770	COG1490	D-aminoacyl-tRNA deacylase activity
WP2W18E01_01800	COG0456	acetyltransferase
WP2W18E01_01820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP2W18E01_01830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18E01_01840	COG2610	gluconate transmembrane transporter activity
WP2W18E01_01850	COG3265	gluconokinase activity
WP2W18E01_01860	COG0129	dihydroxy-acid dehydratase activity
WP2W18E01_01870	COG0800	Aldolase
WP2W18E01_01900	COG1609	Transcriptional regulator
WP2W18E01_01920	COG4942	peptidase
WP2W18E01_01930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP2W18E01_01940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18E01_01950	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP2W18E01_01960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP2W18E01_01970	COG0316	Belongs to the HesB IscA family
WP2W18E01_01970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP2W18E01_01980	COG1040	competence protein
WP2W18E01_01990	COG0596	Alpha beta hydrolase
WP2W18E01_02020	COG2183	response to ionizing radiation
WP2W18E01_02030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2W18E01_02040	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_02050	COG2205	protein histidine kinase activity
WP2W18E01_02070	COG0051	transcription antitermination factor activity, RNA binding
WP2W18E01_02080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP2W18E01_02090	COG0088	Forms part of the polypeptide exit tunnel
WP2W18E01_02100	COG0089	rRNA binding
WP2W18E01_02110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP2W18E01_02120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP2W18E01_02130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP2W18E01_02140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP2W18E01_02150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP2W18E01_02160	COG0255	Belongs to the universal ribosomal protein uL29 family
WP2W18E01_02170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP2W18E01_02180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP2W18E01_02190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP2W18E01_02200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP2W18E01_02210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP2W18E01_02220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP2W18E01_02230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP2W18E01_02240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP2W18E01_02250	COG1841	ribosomal large subunit assembly
WP2W18E01_02260	COG0200	Binds to the 23S rRNA
WP2W18E01_02270	COG0201	protein transport
WP2W18E01_02280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP2W18E01_02290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP2W18E01_02300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP2W18E01_02310	COG0202	RNA polymerase activity
WP2W18E01_02320	COG0203	ribosomal protein L17
WP2W18E01_02330	COG2801	Transposase and inactivated derivatives
WP2W18E01_02340	COG2963	transposase activity
WP2W18E01_02380	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18E01_02390	COG0583	DNA-binding transcription factor activity
WP2W18E01_02400	COG4221	oxidoreductase activity
WP2W18E01_02430	COG1770	oligopeptidase
WP2W18E01_02440	COG2358	TRAP transporter, solute receptor (TAXI family
WP2W18E01_02470	COG3714	YhhN family
WP2W18E01_02500	COG0583	DNA-binding transcription factor activity
WP2W18E01_02520	COG1301	dicarboxylic acid transport
WP2W18E01_02540	COG2095	MarC family integral membrane protein
WP2W18E01_02560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18E01_02580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2W18E01_02600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18E01_02650	COG0742	ribosomal rna small subunit methyltransferase
WP2W18E01_02660	COG0552	protein localization to endoplasmic reticulum
WP2W18E01_02670	COG2884	Cell division ATP-binding protein ftsE
WP2W18E01_02680	COG2177	Part of the ABC transporter FtsEX involved in
WP2W18E01_02700	COG0288	reversible hydration of carbon dioxide
WP2W18E01_02710	COG2188	Transcriptional regulator
WP2W18E01_02720	COG1228	amidohydrolase
WP2W18E01_02730	COG0010	Belongs to the arginase family
WP2W18E01_02740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP2W18E01_02750	COG2986	histidine ammonia-lyase
WP2W18E01_02760	COG0387	Pfam Sodium calcium exchanger
WP2W18E01_02770	COG2200	EAL domain
WP2W18E01_02890	COG1459	type II secretion system
WP2W18E01_03010	COG4372	Transposase
WP2W18E01_03030	COG1077	Cell shape determining protein MreB Mrl
WP2W18E01_03040	COG1792	Involved in formation and maintenance of cell shape
WP2W18E01_03050	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP2W18E01_03060	COG0424	maF-like protein
WP2W18E01_03070	COG1530	ribonuclease E activity
WP2W18E01_03080	COG3164	Protein of unknown function
WP2W18E01_03090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18E01_03100	COG0312	modulator of DNA gyrase
WP2W18E01_03130	COG0477	Major facilitator Superfamily
WP2W18E01_03150	COG2321	neutral zinc metallopeptidase
WP2W18E01_03220	COG0189	ligase activity
WP2W18E01_03230	COG0642	Histidine kinase
WP2W18E01_03240	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_03270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP2W18E01_03280	COG0352	thiamine-phosphate diphosphorylase activity
WP2W18E01_03290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2W18E01_03310	COG2022	thiamine diphosphate biosynthetic process
WP2W18E01_03320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2W18E01_03330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WP2W18E01_03360	COG0110	maltose O-acetyltransferase activity
WP2W18E01_03380	COG3706	GGDEF domain
WP2W18E01_03390	COG3932	Exopolysaccharide synthesis, ExoD
WP2W18E01_03420	COG1733	regulation of RNA biosynthetic process
WP2W18E01_03430	COG0456	acetyltransferase
WP2W18E01_03480	COG2226	methyltransferase
WP2W18E01_03500	COG1494	fructose-1,6-bisphosphatase
WP2W18E01_03520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP2W18E01_03530	COG5007	Belongs to the BolA IbaG family
WP2W18E01_03550	COG2854	intermembrane phospholipid transfer
WP2W18E01_03560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2W18E01_03570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP2W18E01_03580	COG1127	ABC transporter
WP2W18E01_03590	COG0517	IMP dehydrogenase activity
WP2W18E01_03590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP2W18E01_03600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP2W18E01_03620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP2W18E01_03630	COG1137	ATPase activity
WP2W18E01_03640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP2W18E01_03660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_03670	COG1660	Displays ATPase and GTPase activities
WP2W18E01_03680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_03720	COG3964	amidohydrolase
WP2W18E01_03780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18E01_03790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18E01_03810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP2W18E01_03820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP2W18E01_03830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP2W18E01_03840	COG0723	plastoquinol--plastocyanin reductase activity
WP2W18E01_03850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP2W18E01_03860	COG2857	Cytochrome c1
WP2W18E01_03870	COG0625	glutathione transferase activity
WP2W18E01_03880	COG2969	positive regulation of protein catabolic process
WP2W18E01_03890	COG2823	Periplasmic or secreted lipoprotein
WP2W18E01_03900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2W18E01_03910	COG0792	nuclease activity
WP2W18E01_03920	COG3107	peptidoglycan biosynthetic process
WP2W18E01_03930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP2W18E01_03940	COG2001	Belongs to the MraZ family
WP2W18E01_03950	COG0275	rRNA processing
WP2W18E01_03960	COG3116	cell division
WP2W18E01_03970	COG0768	penicillin binding
WP2W18E01_03980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP2W18E01_03990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP2W18E01_04000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP2W18E01_04010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP2W18E01_04020	COG0772	Belongs to the SEDS family
WP2W18E01_04030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP2W18E01_04040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2W18E01_04050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP2W18E01_04060	COG0849	cell division
WP2W18E01_04070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP2W18E01_04080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP2W18E01_04100	COG0653	protein targeting
WP2W18E01_04120	COG0494	nUDIX hydrolase
WP2W18E01_04130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP2W18E01_04140	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP2W18E01_04170	COG1459	type II secretion system
WP2W18E01_04180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2W18E01_04220	COG2186	Transcriptional regulator
WP2W18E01_04230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP2W18E01_04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18E01_04250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E01_04270	COG0840	transmembrane signaling receptor activity
WP2W18E01_04280	COG0840	transmembrane signaling receptor activity
WP2W18E01_04290	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18E01_04300	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP2W18E01_04310	COG2200	EAL domain
WP2W18E01_04330	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_04350	COG0523	cobalamin synthesis protein
WP2W18E01_04360	COG0477	Major facilitator Superfamily
WP2W18E01_04390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP2W18E01_04400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP2W18E01_04470	COG2314	TM2 domain
WP2W18E01_04550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP2W18E01_04570	COG1546	Belongs to the CinA family
WP2W18E01_04580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP2W18E01_04590	COG2137	regulation of response to DNA damage stimulus
WP2W18E01_04600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP2W18E01_04610	COG0527	aspartate kinase activity
WP2W18E01_04620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP2W18E01_04630	COG1686	Belongs to the peptidase S11 family
WP2W18E01_04640	COG0586	Pfam SNARE associated Golgi protein
WP2W18E01_04650	COG1253	flavin adenine dinucleotide binding
WP2W18E01_04660	COG0525	valine-tRNA ligase activity
WP2W18E01_04670	COG2927	DNA polymerase III (CHI subunit)
WP2W18E01_04680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18E01_04690	COG0795	lipopolysaccharide-transporting ATPase activity
WP2W18E01_04700	COG0795	lipopolysaccharide-transporting ATPase activity
WP2W18E01_04720	COG4974	Belongs to the 'phage' integrase family
WP2W18E01_04730	COG2963	transposase activity
WP2W18E01_04740	COG2801	Transposase and inactivated derivatives
WP2W18E01_04760	COG2801	Transposase and inactivated derivatives
WP2W18E01_04830	COG2801	Transposase and inactivated derivatives
WP2W18E01_04850	COG0004	ammonium transporteR
WP2W18E01_04860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18E01_04890	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2W18E01_04900	COG0084	hydrolase, TatD family'
WP2W18E01_04910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18E01_04930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP2W18E01_04940	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP2W18E01_04950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP2W18E01_04980	COG4520	surface antigen
WP2W18E01_04990	COG5002	protein histidine kinase activity
WP2W18E01_04990	COG5001	Diguanylate cyclase
WP2W18E01_04990	COG3447	MASE1 domain protein
WP2W18E01_05010	COG0560	Phosphoserine phosphatase
WP2W18E01_05040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP2W18E01_05060	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP2W18E01_05070	COG0776	regulation of translation
WP2W18E01_05090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18E01_05100	COG0735	belongs to the Fur family
WP2W18E01_05140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP2W18E01_05150	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_05160	COG3022	response to hydroperoxide
WP2W18E01_05170	COG2805	Type II/IV secretion system protein
WP2W18E01_05190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP2W18E01_05200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP2W18E01_05210	COG0762	integral membrane protein
WP2W18E01_05220	COG1872	DUF167
WP2W18E01_05260	COG3112	Uncharacterised protein family (UPF0231)
WP2W18E01_05270	COG3835	regulator
WP2W18E01_05280	COG2610	gluconate transmembrane transporter activity
WP2W18E01_05290	COG1929	Belongs to the glycerate kinase type-1 family
WP2W18E01_05320	COG0583	DNA-binding transcription factor activity
WP2W18E01_05330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18E01_05360	COG0347	Belongs to the P(II) protein family
WP2W18E01_05390	COG3842	ATPase activity
WP2W18E01_05400	COG2837	iron assimilation
WP2W18E01_05410	COG1438	arginine binding
WP2W18E01_05420	COG1126	abc transporter atp-binding protein
WP2W18E01_05430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_05440	COG4215	(ABC) transporter
WP2W18E01_05450	COG4160	amino acid transport
WP2W18E01_05460	COG0039	L-malate dehydrogenase activity
WP2W18E01_05470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP2W18E01_05480	COG1017	nitric oxide dioxygenase activity
WP2W18E01_05480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E01_05500	COG4536	flavin adenine dinucleotide binding
WP2W18E01_05510	COG4137	Cytochrome C assembly protein
WP2W18E01_05520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP2W18E01_05530	COG0228	four-way junction DNA binding
WP2W18E01_05540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP2W18E01_05550	COG0336	Belongs to the RNA methyltransferase TrmD family
WP2W18E01_05560	COG0335	large ribosomal subunit rRNA binding
WP2W18E01_05580	COG3066	DNA modification
WP2W18E01_05590	COG1051	belongs to the nudix hydrolase family
WP2W18E01_05610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP2W18E01_05620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP2W18E01_05630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2W18E01_05650	COG0583	DNA-binding transcription factor activity
WP2W18E01_05660	COG0640	Transcriptional regulator
WP2W18E01_05670	COG0268	Binds directly to 16S ribosomal RNA
WP2W18E01_05680	COG0728	peptidoglycan biosynthetic process
WP2W18E01_05690	COG0196	riboflavin kinase activity
WP2W18E01_05700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP2W18E01_05710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP2W18E01_05720	COG1047	Peptidyl-prolyl cis-trans
WP2W18E01_05730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP2W18E01_05740	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2W18E01_05830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP2W18E01_05830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18E01_05860	COG1854	S-ribosylhomocysteine lyase activity
WP2W18E01_05870	COG3706	GGDEF domain
WP2W18E01_05880	COG0557	exoribonuclease II activity
WP2W18E01_05890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18E01_05910	COG2153	protein acetylation
WP2W18E01_05930	COG1914	H( )-stimulated, divalent metal cation uptake system
WP2W18E01_05950	COG0360	Binds together with S18 to 16S ribosomal RNA
WP2W18E01_05960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP2W18E01_05970	COG0359	binds to the 23S rRNA
WP2W18E01_06050	COG1238	metal cluster binding
WP2W18E01_06060	COG0612	Peptidase, M16
WP2W18E01_06070	COG2918	glutathione biosynthetic process
WP2W18E01_06080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2W18E01_06090	COG1027	Aspartate ammonia-lyase
WP2W18E01_06100	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP2W18E01_06110	COG0534	Mate efflux family protein
WP2W18E01_06120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP2W18E01_06130	COG0459	protein refolding
WP2W18E01_06170	COG0564	pseudouridine synthase activity
WP2W18E01_06180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP2W18E01_06200	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP2W18E01_06220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP2W18E01_06230	COG4208	sulfate ABC transporter
WP2W18E01_06240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP2W18E01_06250	COG0583	DNA-binding transcription factor activity
WP2W18E01_06260	COG3397	chitin binding
WP2W18E01_06270	COG0840	transmembrane signaling receptor activity
WP2W18E01_06320	COG1328	CTP reductase activity
WP2W18E01_06330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2W18E01_06360	COG1448	Aminotransferase
WP2W18E01_06370	COG2194	sulfuric ester hydrolase activity
WP2W18E01_06410	COG1215	transferase activity, transferring glycosyl groups
WP2W18E01_06430	COG0457	Tetratricopeptide repeat
WP2W18E01_06430	COG3118	belongs to the thioredoxin family
WP2W18E01_06510	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_06520	COG0840	transmembrane signaling receptor activity
WP2W18E01_06540	COG4166	transmembrane transport
WP2W18E01_06570	COG1024	Enoyl-CoA hydratase
WP2W18E01_06600	COG4221	oxidoreductase activity
WP2W18E01_06610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E01_06620	COG0442	prolyl-tRNA aminoacylation
WP2W18E01_06630	COG0840	transmembrane signaling receptor activity
WP2W18E01_06640	COG0632	four-way junction helicase activity
WP2W18E01_06650	COG2255	four-way junction helicase activity
WP2W18E01_06660	COG1271	oxidase subunit
WP2W18E01_06670	COG1294	oxidase, subunit
WP2W18E01_06680	COG4890	Cyd operon protein YbgT
WP2W18E01_06690	COG3790	cyd operon protein YbgE
WP2W18E01_06700	COG0824	Thioesterase
WP2W18E01_06710	COG0811	peptide transport
WP2W18E01_06740	COG0823	Involved in the tonB-independent uptake of proteins
WP2W18E01_06750	COG2885	chlorophyll binding
WP2W18E01_06760	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP2W18E01_06770	COG0840	transmembrane signaling receptor activity
WP2W18E01_06780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP2W18E01_06800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2W18E01_06810	COG1640	4-alpha-glucanotransferase
WP2W18E01_06820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP2W18E01_06870	COG1051	belongs to the nudix hydrolase family
WP2W18E01_06880	COG2130	NADP-dependent
WP2W18E01_06890	COG1846	Transcriptional regulator
WP2W18E01_06950	COG0561	phosphatase activity
WP2W18E01_06980	COG0733	neurotransmitter:sodium symporter activity
WP2W18E01_06990	COG0733	neurotransmitter:sodium symporter activity
WP2W18E01_07020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E01_07050	COG1794	racemase activity, acting on amino acids and derivatives
WP2W18E01_07070	COG1022	Amp-dependent synthetase and ligase
WP2W18E01_07090	COG0456	acetyltransferase
WP2W18E01_07120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP2W18E01_07130	COG5001	Diguanylate cyclase
WP2W18E01_07130	COG5002	protein histidine kinase activity
WP2W18E01_07170	COG0456	acetyltransferase
WP2W18E01_07200	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E01_07230	COG2957	Belongs to the agmatine deiminase family
WP2W18E01_07240	COG0154	amidase activity
WP2W18E01_07290	COG2207	Transcriptional regulator
WP2W18E01_07290	COG1917	Cupin 2, conserved barrel domain protein
WP2W18E01_07310	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_07320	COG2203	Gaf domain
WP2W18E01_07320	COG2199	diguanylate cyclase activity
WP2W18E01_07390	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP2W18E01_07410	COG0577	efflux transmembrane transporter activity
WP2W18E01_07410	COG1136	(ABC) transporter
WP2W18E01_07420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_07430	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_07440	COG2205	protein histidine kinase activity
WP2W18E01_07510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18E01_07530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP2W18E01_07550	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP2W18E01_07560	COG1178	ABC-type Fe3 transport system permease component
WP2W18E01_07570	COG4143	(ABC) transporter
WP2W18E01_07600	COG0066	3-isopropylmalate dehydratase activity
WP2W18E01_07610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP2W18E01_07620	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18E01_07630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2W18E01_07650	COG0671	phosphoesterase, PA-phosphatase related
WP2W18E01_07680	COG0028	Belongs to the TPP enzyme family
WP2W18E01_07690	COG0440	acetolactate synthase activity
WP2W18E01_07700	COG0857	belongs to the CobB CobQ family
WP2W18E01_07700	COG0280	phosphate acetyltransferase
WP2W18E01_07710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP2W18E01_07740	COG3013	Belongs to the UPF0304 family
WP2W18E01_07750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP2W18E01_07760	COG2716	regulation of RNA biosynthetic process
WP2W18E01_07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18E01_07780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP2W18E01_07790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP2W18E01_07820	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP2W18E01_07860	COG0784	Response regulator, receiver
WP2W18E01_07860	COG2198	Histidine kinase
WP2W18E01_07860	COG5002	protein histidine kinase activity
WP2W18E01_07870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WP2W18E01_07890	COG0784	Response regulator, receiver
WP2W18E01_07890	COG2205	protein histidine kinase activity
WP2W18E01_07930	COG1464	Belongs to the NlpA lipoprotein family
WP2W18E01_07940	COG2011	ABC-type metal ion transport system permease component
WP2W18E01_07950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18E01_07990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP2W18E01_07990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP2W18E01_08000	COG0802	atpase or kinase
WP2W18E01_08020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP2W18E01_08030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP2W18E01_08040	COG1923	regulation of RNA biosynthetic process
WP2W18E01_08050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP2W18E01_08060	COG0330	HflC and HflK could
WP2W18E01_08070	COG0330	HflC and HflK could
WP2W18E01_08080	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP2W18E01_08090	COG0142	geranyltranstransferase activity
WP2W18E01_08100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP2W18E01_08110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP2W18E01_08120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP2W18E01_08140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18E01_08150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2W18E01_08170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2W18E01_08180	COG2967	ApaG domain
WP2W18E01_08190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP2W18E01_08220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP2W18E01_08230	COG3178	'Phosphotransferase
WP2W18E01_08240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP2W18E01_08250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2W18E01_08260	COG2252	PERMEase
WP2W18E01_08280	COG0488	(ABC) transporter
WP2W18E01_08290	COG0741	lytic transglycosylase activity
WP2W18E01_08300	COG0463	Glycosyl transferase, family 2
WP2W18E01_08320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WP2W18E01_08370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18E01_08390	COG3721	Heme iron utilization protein
WP2W18E01_08400	COG0748	coenzyme F420 binding
WP2W18E01_08450	COG2814	Major facilitator Superfamily
WP2W18E01_08460	COG2202	Pas domain
WP2W18E01_08460	COG2205	protein histidine kinase activity
WP2W18E01_08490	COG2226	methyltransferase
WP2W18E01_08510	COG1765	OsmC-like protein
WP2W18E01_08540	COG3954	Phosphoribulokinase
WP2W18E01_08550	COG3089	Belongs to the UPF0270 family
WP2W18E01_08560	COG3706	GGDEF domain
WP2W18E01_08560	COG2203	Gaf domain
WP2W18E01_08560	COG4251	negative regulation of phosphorylation
WP2W18E01_08560	COG5001	Diguanylate cyclase
WP2W18E01_08570	COG0429	hydrolase of the alpha beta-hydrolase fold
WP2W18E01_08580	COG0784	Response regulator, receiver
WP2W18E01_08580	COG0835	chemotaxis
WP2W18E01_08600	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP2W18E01_08610	COG1047	Peptidyl-prolyl cis-trans
WP2W18E01_08620	COG2900	Belongs to the SlyX family
WP2W18E01_08640	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2W18E01_08650	COG2204	response regulator
WP2W18E01_08690	COG0737	Belongs to the 5'-nucleotidase family
WP2W18E01_08720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18E01_08730	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18E01_08730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18E01_08730	COG0506	proline dehydrogenase activity
WP2W18E01_08750	COG0114	fumarate hydratase activity
WP2W18E01_08770	COG1566	PFAM secretion protein HlyD family protein
WP2W18E01_08900	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_08910	COG0826	peptidase U32
WP2W18E01_08930	COG3813	Protein conserved in bacteria
WP2W18E01_08970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP2W18E01_09020	COG0300	oxidoreductase activity
WP2W18E01_09060	COG2610	gluconate transmembrane transporter activity
WP2W18E01_09070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2W18E01_09080	COG3622	Belongs to the hyi family
WP2W18E01_09090	COG0235	Class ii aldolase
WP2W18E01_09110	COG2084	Dehydrogenase
WP2W18E01_09120	COG1349	DNA-binding transcription factor activity
WP2W18E01_09140	COG2133	pyrroloquinoline quinone binding
WP2W18E01_09190	COG3385	transposase activity
WP2W18E01_09280	COG1192	Involved in chromosome partitioning
WP2W18E01_09320	COG2948	multi-organism process
WP2W18E01_09330	COG0583	DNA-binding transcription factor activity
WP2W18E01_09340	COG1846	Transcriptional regulator
WP2W18E01_09410	COG0583	DNA-binding transcription factor activity
WP2W18E01_09430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18E01_09440	COG0625	glutathione transferase activity
WP2W18E01_09480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18E01_09480	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18E01_09500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18E01_09540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18E01_09550	COG3385	transposase activity
WP2W18E01_09590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18E01_09670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP2W18E01_09700	COG1715	Restriction endonuclease
WP2W18E01_09810	COG2003	Belongs to the UPF0758 family
WP2W18E01_09900	COG5377	YqaJ viral recombinase family
WP2W18E01_09950	COG1605	Chorismate mutase
WP2W18E01_09950	COG0077	Prephenate dehydratase
WP2W18E01_10000	COG3272	Protein of unknown function (DUF1722)
WP2W18E01_10010	COG0789	Transcriptional regulator
WP2W18E01_10020	COG0415	Belongs to the DNA photolyase family
WP2W18E01_10040	COG4221	oxidoreductase activity
WP2W18E01_10070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2W18E01_10120	COG0783	Belongs to the Dps family
WP2W18E01_10130	COG1151	hydroxylamine reductase activity
WP2W18E01_10150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18E01_10180	COG4372	Transposase
WP2W18E01_10190	COG2314	TM2 domain
WP2W18E01_10210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18E01_10230	COG1136	(ABC) transporter
WP2W18E01_10380	COG2003	Belongs to the UPF0758 family
WP2W18E01_10470	COG5377	YqaJ viral recombinase family
WP2W18E01_10530	COG0582	viral genome integration into host DNA
WP2W18E01_10550	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP2W18E01_10560	COG2723	6-phospho-beta-galactosidase activity
WP2W18E01_10580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2W18E01_10590	COG5297	Belongs to the glycosyl hydrolase family 6
WP2W18E01_10590	COG2273	Hydrolase Family 16
WP2W18E01_10600	COG1472	Belongs to the glycosyl hydrolase 3 family
WP2W18E01_10610	COG0840	transmembrane signaling receptor activity
WP2W18E01_10620	COG2182	Extracellular solute-binding protein
WP2W18E01_10630	COG1609	Transcriptional regulator
WP2W18E01_10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_10690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_10700	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_10710	COG5002	protein histidine kinase activity
WP2W18E01_10710	COG5000	phosphorelay sensor kinase activity
WP2W18E01_10720	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18E01_10750	COG1666	GTP binding
WP2W18E01_10770	COG2211	Major facilitator Superfamily
WP2W18E01_10790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2W18E01_10810	COG2813	Specifically methylates the guanine in position
WP2W18E01_10820	COG0271	Belongs to the BolA IbaG family
WP2W18E01_10830	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18E01_10840	COG1805	sodium ion transport
WP2W18E01_10850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18E01_10860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18E01_10870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18E01_10880	COG2871	sodium ion transport
WP2W18E01_10890	COG1477	protein flavinylation
WP2W18E01_10920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18E01_10930	COG0840	transmembrane signaling receptor activity
WP2W18E01_10940	COG0583	DNA-binding transcription factor activity
WP2W18E01_10960	COG2363	Small membrane protein
WP2W18E01_10970	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP2W18E01_10990	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18E01_11000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18E01_11010	COG1611	Belongs to the LOG family
WP2W18E01_11020	COG3706	GGDEF domain
WP2W18E01_11040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2W18E01_11040	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2W18E01_11060	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP2W18E01_11110	COG3098	single-species biofilm formation
WP2W18E01_11120	COG0564	pseudouridine synthase activity
WP2W18E01_11160	COG1263	PTS System
WP2W18E01_11160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_11180	COG2171	N-acyltransferase activity
WP2W18E01_11190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP2W18E01_11200	COG0024	Methionine aminopeptidase
WP2W18E01_11210	COG0052	Belongs to the universal ribosomal protein uS2 family
WP2W18E01_11220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP2W18E01_11230	COG0528	UMP kinase activity
WP2W18E01_11240	COG0233	cytoplasmic translational termination
WP2W18E01_11250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP2W18E01_11260	COG0575	Belongs to the CDS family
WP2W18E01_11270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP2W18E01_11280	COG0750	zinc metalloprotease
WP2W18E01_11310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E01_11320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2W18E01_11330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E01_11340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E01_11350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP2W18E01_11370	COG0825	malonyl-CoA metabolic process
WP2W18E01_11400	COG0814	amino acid
WP2W18E01_11410	COG0531	amino acid
WP2W18E01_11430	COG0488	(ABC) transporter
WP2W18E01_11450	COG3590	peptidase
WP2W18E01_11460	COG0037	tRNA processing
WP2W18E01_11470	COG3706	GGDEF domain
WP2W18E01_11540	COG0366	Alpha amylase catalytic
WP2W18E01_11570	COG0463	Glycosyl transferase, family 2
WP2W18E01_11600	COG2989	Protein conserved in bacteria
WP2W18E01_11610	COG3108	Peptidase M15
WP2W18E01_11630	COG2860	membrane
WP2W18E01_11650	COG1196	nuclear chromosome segregation
WP2W18E01_11660	COG3115	cell septum assembly
WP2W18E01_11670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP2W18E01_11690	COG1328	CTP reductase activity
WP2W18E01_11700	COG0602	queuosine metabolic process
WP2W18E01_11750	COG1566	PFAM secretion protein HlyD family protein
WP2W18E01_11770	COG3290	protein histidine kinase activity
WP2W18E01_11800	COG0667	Aldo Keto reductase
WP2W18E01_11810	COG0697	spore germination
WP2W18E01_11830	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_11840	COG3284	Transcriptional regulator
WP2W18E01_11850	COG3706	GGDEF domain
WP2W18E01_11860	COG0346	lactoylglutathione lyase activity
WP2W18E01_11870	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_11880	COG5002	protein histidine kinase activity
WP2W18E01_11900	COG4783	chaperone-mediated protein folding
WP2W18E01_11920	COG1940	carbohydrate kinase activity
WP2W18E01_11930	COG3142	Participates in the control of copper homeostasis
WP2W18E01_11940	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2W18E01_11950	COG1131	(ABC) transporter
WP2W18E01_11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_11990	COG4597	amino acid ABC transporter
WP2W18E01_12000	COG0765	amino acid transport
WP2W18E01_12010	COG1126	abc transporter atp-binding protein
WP2W18E01_12030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP2W18E01_12040	COG0678	peroxiredoxin activity
WP2W18E01_12060	COG0019	diaminopimelate decarboxylase activity
WP2W18E01_12070	COG1115	amino acid carrier protein
WP2W18E01_12080	COG0095	Lipoate-protein ligase
WP2W18E01_12090	COG2233	PERMEase
WP2W18E01_12120	COG0534	Mate efflux family protein
WP2W18E01_12130	COG2207	Transcriptional regulator
WP2W18E01_12140	COG0281	malic enzyme
WP2W18E01_12200	COG0733	neurotransmitter:sodium symporter activity
WP2W18E01_12220	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18E01_12230	COG3706	GGDEF domain
WP2W18E01_12250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_12270	COG1032	radical SAM domain protein
WP2W18E01_12310	COG0673	inositol 2-dehydrogenase activity
WP2W18E01_12320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP2W18E01_12330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2W18E01_12340	COG0741	lytic transglycosylase activity
WP2W18E01_12340	COG1196	nuclear chromosome segregation
WP2W18E01_12340	COG0739	heme binding
WP2W18E01_12390	COG0788	formyltetrahydrofolate deformylase activity
WP2W18E01_12400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2W18E01_12420	COG3118	belongs to the thioredoxin family
WP2W18E01_12440	COG0791	NLP P60 protein
WP2W18E01_12450	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP2W18E01_12480	COG1376	ErfK ybiS ycfS ynhG family protein
WP2W18E01_12480	COG1388	LysM domain
WP2W18E01_12560	COG0583	DNA-binding transcription factor activity
WP2W18E01_12600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_12630	COG4959	Type IV secretory pathway protease TraF
WP2W18E01_12720	COG1203	CRISPR-associated helicase, Cas3
WP2W18E01_12730	COG1518	maintenance of DNA repeat elements
WP2W18E01_12800	COG2003	Belongs to the UPF0758 family
WP2W18E01_12890	COG3311	Transcriptional regulator
WP2W18E01_12910	COG0582	viral genome integration into host DNA
WP2W18E01_12920	COG2205	protein histidine kinase activity
WP2W18E01_12920	COG0784	Response regulator, receiver
WP2W18E01_12950	COG0784	Response regulator, receiver
WP2W18E01_12950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_12950	COG2198	Histidine kinase
WP2W18E01_12950	COG2205	protein histidine kinase activity
WP2W18E01_12960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_12960	COG2205	protein histidine kinase activity
WP2W18E01_12970	COG3384	dioxygenase
WP2W18E01_12990	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP2W18E01_13010	COG0531	amino acid
WP2W18E01_13030	COG0531	amino acid
WP2W18E01_13060	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_13070	COG1396	sequence-specific DNA binding
WP2W18E01_13070	COG1917	Cupin 2, conserved barrel domain protein
WP2W18E01_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18E01_13150	COG4651	solute:proton antiporter activity
WP2W18E01_13150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP2W18E01_13160	COG0405	Gamma-glutamyltransferase
WP2W18E01_13180	COG2974	May be involved in recombination
WP2W18E01_13190	COG1247	-acetyltransferase
WP2W18E01_13200	COG0420	3'-5' exonuclease activity
WP2W18E01_13220	COG3038	cytochrome b561
WP2W18E01_13230	COG2190	(PTS) system
WP2W18E01_13250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_13260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP2W18E01_13270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18E01_13300	COG1720	tRNA m6t6A37 methyltransferase activity
WP2W18E01_13350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP2W18E01_13360	COG4988	ABC transporter
WP2W18E01_13370	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_13400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18E01_13430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP2W18E01_13440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP2W18E01_13460	COG0083	homoserine kinase activity
WP2W18E01_13470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2W18E01_13480	COG4319	ketosteroid isomerase
WP2W18E01_13530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP2W18E01_13550	COG3220	belongs to the UPF0276 family
WP2W18E01_13610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18E01_13620	COG1289	transmembrane transporter activity
WP2W18E01_13630	COG1763	Mo-molybdopterin cofactor biosynthetic process
WP2W18E01_13640	COG0746	molybdenum cofactor guanylyltransferase activity
WP2W18E01_13650	COG0281	malic enzyme
WP2W18E01_13710	COG1196	nuclear chromosome segregation
WP2W18E01_13710	COG3264	Mechanosensitive ion channel
WP2W18E01_13730	COG2850	peptidyl-arginine hydroxylation
WP2W18E01_13740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP2W18E01_13750	COG2915	High frequency lysogenization protein hflD homolog
WP2W18E01_13760	COG0482	sulfurtransferase activity
WP2W18E01_13780	COG1187	pseudouridine synthase activity
WP2W18E01_13790	COG0456	acetyltransferase
WP2W18E01_13860	COG0538	isocitrate dehydrogenase activity
WP2W18E01_13880	COG3048	D-serine ammonia-lyase activity
WP2W18E01_13890	COG0583	DNA-binding transcription factor activity
WP2W18E01_13900	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18E01_13960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18E01_13970	COG2375	cellular response to nickel ion
WP2W18E01_13980	COG1538	Outer membrane efflux protein
WP2W18E01_13990	COG0577	efflux transmembrane transporter activity
WP2W18E01_13990	COG1136	(ABC) transporter
WP2W18E01_14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_14020	COG0497	DNA recombination
WP2W18E01_14030	COG3706	GGDEF domain
WP2W18E01_14040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP2W18E01_14050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP2W18E01_14060	COG0443	Heat shock 70 kDa protein
WP2W18E01_14070	COG0484	heat shock protein binding
WP2W18E01_14120	COG1285	pathogenesis
WP2W18E01_14140	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E01_14160	COG0640	Transcriptional regulator
WP2W18E01_14240	COG0095	Lipoate-protein ligase
WP2W18E01_14270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_14280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_14300	COG0708	Exodeoxyribonuclease III
WP2W18E01_14320	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_14350	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WP2W18E01_14380	COG1846	Transcriptional regulator
WP2W18E01_14420	COG0583	DNA-binding transcription factor activity
WP2W18E01_14430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2W18E01_14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP2W18E01_14450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP2W18E01_14460	COG1845	cytochrome c oxidase, subunit III
WP2W18E01_14470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP2W18E01_14480	COG0109	protoheme IX farnesyltransferase activity
WP2W18E01_14490	COG0109	protoheme IX farnesyltransferase activity
WP2W18E01_14500	COG2814	Major facilitator Superfamily
WP2W18E01_14510	COG5507	3-demethylubiquinone-9 3-methyltransferase
WP2W18E01_14570	COG3550	peptidyl-serine autophosphorylation
WP2W18E01_14580	COG1396	sequence-specific DNA binding
WP2W18E01_14590	COG1988	membrane-bound metal-dependent
WP2W18E01_14650	COG0159	tryptophan synthase activity
WP2W18E01_14660	COG0133	tryptophan synthase activity
WP2W18E01_14670	COG0134	indole-3-glycerol-phosphate synthase activity
WP2W18E01_14670	COG0135	phosphoribosylanthranilate isomerase activity
WP2W18E01_14680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2W18E01_14690	COG0512	Glutamine amidotransferase of anthranilate synthase
WP2W18E01_14690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2W18E01_14700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP2W18E01_14710	COG0613	PHP domain protein
WP2W18E01_14720	COG0009	L-threonylcarbamoyladenylate synthase
WP2W18E01_14740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP2W18E01_14770	COG1946	Acyl-CoA thioesterase
WP2W18E01_14800	COG1309	transcriptional regulator
WP2W18E01_14810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_14820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_14850	COG3039	Transposase
WP2W18E01_14970	COG2003	Belongs to the UPF0758 family
WP2W18E01_15000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP2W18E01_15030	COG0583	DNA-binding transcription factor activity
WP2W18E01_15050	COG0582	viral genome integration into host DNA
WP2W18E01_15060	COG4983	Phage plasmid primase, P4 family domain protein
WP2W18E01_15120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WP2W18E01_15220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18E01_15270	COG4584	PFAM Integrase catalytic
WP2W18E01_15280	COG1484	DNA-dependent DNA replication
WP2W18E01_15290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP2W18E01_15310	COG1401	restriction endodeoxyribonuclease activity
WP2W18E01_15310	COG1401	restriction endodeoxyribonuclease activity
WP2W18E01_15320	COG0732	type I restriction modification DNA specificity domain
WP2W18E01_15330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP2W18E01_15430	COG2003	Belongs to the UPF0758 family
WP2W18E01_15520	COG5377	YqaJ viral recombinase family
WP2W18E01_15540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP2W18E01_15560	COG1960	acyl-CoA dehydrogenase activity
WP2W18E01_15570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E01_15590	COG0469	pyruvate kinase activity
WP2W18E01_15600	COG1737	Transcriptional regulator
WP2W18E01_15620	COG2205	protein histidine kinase activity
WP2W18E01_15630	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_15650	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP2W18E01_15710	COG1215	transferase activity, transferring glycosyl groups
WP2W18E01_15760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP2W18E01_15770	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WP2W18E01_15840	COG4372	Transposase
WP2W18E01_15860	COG3132	Protein of unknown function, DUF480
WP2W18E01_15940	COG1278	Cold shock
WP2W18E01_16000	COG4166	transmembrane transport
WP2W18E01_16010	COG0697	spore germination
WP2W18E01_16030	COG0675	Transposase, IS605 OrfB family
WP2W18E01_16050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18E01_16080	COG4166	transmembrane transport
WP2W18E01_16090	COG0622	Phosphoesterase
WP2W18E01_16120	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP2W18E01_16130	COG0835	chemotaxis
WP2W18E01_16130	COG0784	Response regulator, receiver
WP2W18E01_16140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP2W18E01_16150	COG1815	bacterial-type flagellum-dependent cell motility
WP2W18E01_16180	COG1749	Flagellar hook protein flgE
WP2W18E01_16210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP2W18E01_16220	COG1706	bacterial-type flagellum-dependent cell motility
WP2W18E01_16230	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP2W18E01_16230	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP2W18E01_16260	COG2239	Acts as a magnesium transporter
WP2W18E01_16280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP2W18E01_16290	COG2716	regulation of RNA biosynthetic process
WP2W18E01_16320	COG5433	transposase activity
WP2W18E01_16330	COG3852	Histidine kinase
WP2W18E01_16350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP2W18E01_16360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP2W18E01_16370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP2W18E01_16380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP2W18E01_16420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP2W18E01_16440	COG0590	tRNA wobble adenosine to inosine editing
WP2W18E01_16450	COG0573	inorganic phosphate transmembrane transporter activity
WP2W18E01_16460	COG0581	inorganic phosphate transmembrane transporter activity
WP2W18E01_16480	COG0704	Plays a role in the regulation of phosphate uptake
WP2W18E01_16490	COG1253	flavin adenine dinucleotide binding
WP2W18E01_16520	COG0531	amino acid
WP2W18E01_16550	COG1126	abc transporter atp-binding protein
WP2W18E01_16570	COG0765	amino acid transport
WP2W18E01_16580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_16590	COG3706	GGDEF domain
WP2W18E01_16600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2W18E01_16640	COG1785	Belongs to the alkaline phosphatase family
WP2W18E01_16650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP2W18E01_16660	COG0477	Major facilitator Superfamily
WP2W18E01_16670	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP2W18E01_16690	COG1199	ATP-dependent helicase activity
WP2W18E01_16700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WP2W18E01_16720	COG1448	Aminotransferase
WP2W18E01_16730	COG0433	COG0433 Predicted ATPase
WP2W18E01_16760	COG2333	competence protein COMEC
WP2W18E01_16760	COG0658	competence protein
WP2W18E01_16770	COG1132	(ABC) transporter
WP2W18E01_16780	COG1663	tetraacyldisaccharide 4'-kinase activity
WP2W18E01_16790	COG2835	tetraacyldisaccharide 4'-kinase activity
WP2W18E01_16800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP2W18E01_16810	COG2197	response regulator
WP2W18E01_16820	COG0322	excinuclease ABC activity
WP2W18E01_16850	COG0604	alcohol dehydrogenase
WP2W18E01_16860	COG1309	transcriptional regulator
WP2W18E01_16870	COG2261	transglycosylase associated protein
WP2W18E01_16880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E01_16900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2W18E01_16960	COG2203	Gaf domain
WP2W18E01_16960	COG2199	diguanylate cyclase activity
WP2W18E01_17030	COG2119	membrane
WP2W18E01_17040	COG0023	Translation Initiation Factor
WP2W18E01_17060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP2W18E01_17110	COG4139	cobalamin transport
WP2W18E01_17120	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP2W18E01_17130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18E01_17140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP2W18E01_17150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18E01_17160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP2W18E01_17170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP2W18E01_17200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP2W18E01_17210	COG0505	Belongs to the CarA family
WP2W18E01_17220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP2W18E01_17230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2W18E01_17240	COG3706	GGDEF domain
WP2W18E01_17260	COG2801	Transposase and inactivated derivatives
WP2W18E01_17330	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_17350	COG4104	PAAR repeat-containing protein
WP2W18E01_17390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_17400	COG5433	transposase activity
WP2W18E01_17410	COG0765	amino acid transport
WP2W18E01_17430	COG0493	'glutamate synthase
WP2W18E01_17440	COG0067	glutamate synthase
WP2W18E01_17440	COG0069	glutamate synthase activity
WP2W18E01_17440	COG0070	glutamate synthase
WP2W18E01_17450	COG1242	4 iron, 4 sulfur cluster binding
WP2W18E01_17460	COG2274	protein secretion by the type I secretion system
WP2W18E01_17470	COG1132	(ABC) transporter
WP2W18E01_17500	COG5433	transposase activity
WP2W18E01_17620	COG1113	amino acid transport
WP2W18E01_17640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP2W18E01_17650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP2W18E01_17650	COG0574	Belongs to the PEP-utilizing enzyme family
WP2W18E01_17670	COG2199	diguanylate cyclase activity
WP2W18E01_17670	COG2203	Gaf domain
WP2W18E01_17680	COG1119	ATPase activity
WP2W18E01_17720	COG1464	Belongs to the NlpA lipoprotein family
WP2W18E01_17740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18E01_17750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2W18E01_17770	COG0101	tRNA pseudouridine synthase activity
WP2W18E01_17780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP2W18E01_17790	COG0285	dihydrofolate synthase activity
WP2W18E01_17800	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP2W18E01_17810	COG2920	part of a sulfur-relay system
WP2W18E01_17820	COG1289	transmembrane transporter activity
WP2W18E01_17830	COG0670	Belongs to the BI1 family
WP2W18E01_17910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP2W18E01_17930	COG2175	clavaminate synthase activity
WP2W18E01_17940	COG3246	L-lysine catabolic process to acetate
WP2W18E01_17950	COG2814	Major facilitator Superfamily
WP2W18E01_17970	COG2855	membrane
WP2W18E01_18050	COG5433	transposase activity
WP2W18E01_18090	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E01_18110	COG5001	Diguanylate cyclase
WP2W18E01_18120	COG0564	pseudouridine synthase activity
WP2W18E01_18150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP2W18E01_18170	COG0625	glutathione transferase activity
WP2W18E01_18200	COG0367	asparagine synthase
WP2W18E01_18220	COG0647	UMP catabolic process
WP2W18E01_18230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2W18E01_18250	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E01_18260	COG1253	flavin adenine dinucleotide binding
WP2W18E01_18280	COG0247	lactate metabolic process
WP2W18E01_18280	COG0277	FAD linked oxidase domain protein
WP2W18E01_18300	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18E01_18330	COG5001	Diguanylate cyclase
WP2W18E01_18340	COG0583	DNA-binding transcription factor activity
WP2W18E01_18350	COG2814	Major facilitator Superfamily
WP2W18E01_18360	COG2056	Na+-H+ antiporter family
WP2W18E01_18370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E01_18400	COG0483	inositol monophosphate 1-phosphatase activity
WP2W18E01_18420	COG0625	glutathione transferase activity
WP2W18E01_18430	COG0625	glutathione transferase activity
WP2W18E01_18450	COG0601	transmembrane transport
WP2W18E01_18460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18E01_18480	COG2814	Major facilitator Superfamily
WP2W18E01_18510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E01_18520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E01_18530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP2W18E01_18540	COG0509	glycine decarboxylation via glycine cleavage system
WP2W18E01_18550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2W18E01_18550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2W18E01_18590	COG0477	Major facilitator Superfamily
WP2W18E01_18600	COG3634	alkyl hydroperoxide reductase activity
WP2W18E01_18610	COG0450	alkyl hydroperoxide reductase
WP2W18E01_18620	COG0517	IMP dehydrogenase activity
WP2W18E01_18630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP2W18E01_18640	COG0343	queuine tRNA-ribosyltransferase activity
WP2W18E01_18650	COG1862	Preprotein translocase
WP2W18E01_18660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18E01_18670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18E01_18700	COG0826	peptidase U32
WP2W18E01_18710	COG0826	peptidase U32
WP2W18E01_18720	COG3154	lipid carrier protein
WP2W18E01_18750	COG1104	cysteine desulfurase activity
WP2W18E01_18760	COG0822	iron-sulfur transferase activity
WP2W18E01_18780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2W18E01_18790	COG0443	Heat shock 70 kDa protein
WP2W18E01_18800	COG0633	Ferredoxin
WP2W18E01_18820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18E01_18830	COG0105	UTP biosynthetic process
WP2W18E01_18840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP2W18E01_18860	COG1426	Protein conserved in bacteria
WP2W18E01_18880	COG0124	histidyl-tRNA synthetase
WP2W18E01_18890	COG2976	Protein conserved in bacteria
WP2W18E01_18900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18E01_18910	COG1160	GTP binding
WP2W18E01_18920	COG1645	bacterial-type flagellum-dependent swarming motility
WP2W18E01_18940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2W18E01_18950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP2W18E01_18950	COG0047	phosphoribosylformylglycinamidine synthase activity
WP2W18E01_18960	COG1007	ATP synthesis coupled electron transport
WP2W18E01_18970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E01_18990	COG0713	ATP synthesis coupled electron transport
WP2W18E01_19000	COG0839	Belongs to the complex I subunit 6 family
WP2W18E01_19010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E01_19020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP2W18E01_19030	COG1034	ATP synthesis coupled electron transport
WP2W18E01_19060	COG0649	NAD binding
WP2W18E01_19060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E01_19070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E01_19080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E01_19090	COG1360	Flagellar Motor Protein
WP2W18E01_19100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18E01_19120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_19170	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP2W18E01_19210	COG0724	RNA recognition motif
WP2W18E01_19220	COG4989	oxidoreductase activity
WP2W18E01_19270	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_19280	COG0583	DNA-binding transcription factor activity
WP2W18E01_19300	COG5001	Diguanylate cyclase
WP2W18E01_19300	COG3300	MHYT domain
WP2W18E01_19310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP2W18E01_19370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2W18E01_19380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP2W18E01_19390	COG0539	negative regulation of cytoplasmic translation
WP2W18E01_19400	COG0776	regulation of translation
WP2W18E01_19420	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP2W18E01_19460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP2W18E01_19470	COG0602	queuosine metabolic process
WP2W18E01_19480	COG3530	Putative quorum-sensing-regulated virulence factor
WP2W18E01_19490	COG2096	Adenosyltransferase
WP2W18E01_19500	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18E01_19510	COG1757	Na H antiporter
WP2W18E01_19520	COG1435	thymidine kinase activity
WP2W18E01_19560	COG1737	Transcriptional regulator
WP2W18E01_19570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_19570	COG2190	(PTS) system
WP2W18E01_19570	COG1263	PTS System
WP2W18E01_19580	COG2723	6-phospho-beta-galactosidase activity
WP2W18E01_19620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP2W18E01_19630	COG3550	peptidyl-serine autophosphorylation
WP2W18E01_19780	COG2205	protein histidine kinase activity
WP2W18E01_19780	COG5002	protein histidine kinase activity
WP2W18E01_19780	COG0784	Response regulator, receiver
WP2W18E01_19800	COG2801	Transposase and inactivated derivatives
WP2W18E01_19820	COG3039	Transposase
WP2W18E01_19880	COG2801	Transposase and inactivated derivatives
WP2W18E01_19890	COG5433	transposase activity
WP2W18E01_19960	COG3039	Transposase
WP2W18E01_19970	COG2226	methyltransferase
WP2W18E01_20000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP2W18E01_20010	COG0626	cystathionine gamma-synthase activity
WP2W18E01_20030	COG2910	NAD(P)H-binding
WP2W18E01_20040	COG0583	DNA-binding transcription factor activity
WP2W18E01_20050	COG4977	sequence-specific DNA binding
WP2W18E01_20050	COG1917	Cupin 2, conserved barrel domain protein
WP2W18E01_20060	COG2200	EAL domain
WP2W18E01_20070	COG3706	GGDEF domain
WP2W18E01_20080	COG4774	siderophore transport
WP2W18E01_20100	COG0583	DNA-binding transcription factor activity
WP2W18E01_20110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP2W18E01_20130	COG0517	IMP dehydrogenase activity
WP2W18E01_20130	COG0617	tRNA 3'-terminal CCA addition
WP2W18E01_20130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2W18E01_20160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18E01_20170	COG3046	protein related to deoxyribodipyrimidine photolyase
WP2W18E01_20190	COG3088	subunit of a heme lyase
WP2W18E01_20190	COG4235	cytochrome complex assembly
WP2W18E01_20200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18E01_20210	COG1138	Cytochrome C-type biogenesis protein
WP2W18E01_20220	COG3301	Polysulphide reductase, NrfD
WP2W18E01_20230	COG0437	4 iron, 4 sulfur cluster binding
WP2W18E01_20240	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP2W18E01_20290	COG0247	lactate metabolic process
WP2W18E01_20310	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP2W18E01_20320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP2W18E01_20330	COG3012	SEC-C Motif Domain Protein
WP2W18E01_20340	COG0840	transmembrane signaling receptor activity
WP2W18E01_20350	COG1940	carbohydrate kinase activity
WP2W18E01_20350	COG1846	Transcriptional regulator
WP2W18E01_20360	COG3290	protein histidine kinase activity
WP2W18E01_20370	COG4565	transcriptional regulatory protein
WP2W18E01_20410	COG0739	heme binding
WP2W18E01_20410	COG1196	nuclear chromosome segregation
WP2W18E01_20410	COG0741	lytic transglycosylase activity
WP2W18E01_20420	COG2985	domain, Protein
WP2W18E01_20420	COG0569	domain protein
WP2W18E01_20440	COG0556	nucleotide-excision repair
WP2W18E01_20460	COG0586	Pfam SNARE associated Golgi protein
WP2W18E01_20470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP2W18E01_20480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2W18E01_20490	COG2186	Transcriptional regulator
WP2W18E01_20500	COG2719	SpoVR family
WP2W18E01_20510	COG2718	Belongs to the UPF0229 family
WP2W18E01_20520	COG2766	serine protein kinase
WP2W18E01_20530	COG0514	ATP-dependent DNA helicase (RecQ)
WP2W18E01_20540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP2W18E01_20550	COG0814	amino acid
WP2W18E01_20620	COG0058	SHG alpha-glucan phosphorylase activity
WP2W18E01_20650	COG0471	metal ion transport
WP2W18E01_20660	COG3118	belongs to the thioredoxin family
WP2W18E01_20680	COG1132	(ABC) transporter
WP2W18E01_20690	COG1132	(ABC) transporter
WP2W18E01_20720	COG2501	S4 domain
WP2W18E01_20740	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP2W18E01_20780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP2W18E01_20790	COG2329	Antibiotic biosynthesis monooxygenase
WP2W18E01_20840	COG1742	UPF0060 membrane protein
WP2W18E01_20870	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_20880	COG0386	Belongs to the glutathione peroxidase family
WP2W18E01_20900	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP2W18E01_20920	COG0730	response to heat
WP2W18E01_20940	COG5433	transposase activity
WP2W18E01_20950	COG0583	DNA-binding transcription factor activity
WP2W18E01_20980	COG3593	DNA synthesis involved in DNA repair
WP2W18E01_21000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18E01_21010	COG1011	Hydrolase
WP2W18E01_21020	COG1473	amidohydrolase
WP2W18E01_21030	COG0205	6-phosphofructokinase activity
WP2W18E01_21050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP2W18E01_21060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18E01_21080	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP2W18E01_21090	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP2W18E01_21100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2W18E01_21150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WP2W18E01_21160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18E01_21220	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_21250	COG2824	Alkylphosphonate utilization operon protein PhnA
WP2W18E01_21320	COG2840	Smr protein MutS2
WP2W18E01_21330	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2W18E01_21340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP2W18E01_21360	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_21370	COG5654	RES domain protein
WP2W18E01_21390	COG0814	amino acid
WP2W18E01_21400	COG1609	Transcriptional regulator
WP2W18E01_21410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_21410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_21420	COG1105	Belongs to the carbohydrate kinase PfkB family
WP2W18E01_21430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18E01_21430	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP2W18E01_21430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18E01_21440	COG3313	Fe-S protein
WP2W18E01_21450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP2W18E01_21460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E01_21470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18E01_21480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18E01_21500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18E01_21550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP2W18E01_21560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP2W18E01_21570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP2W18E01_21580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP2W18E01_21590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP2W18E01_21600	COG0072	phenylalanine-tRNA ligase activity
WP2W18E01_21600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E01_21610	COG0776	regulation of translation
WP2W18E01_21720	COG4772	TonB-dependent receptor
WP2W18E01_21730	COG0840	transmembrane signaling receptor activity
WP2W18E01_21760	COG5001	Diguanylate cyclase
WP2W18E01_21760	COG3300	MHYT domain
WP2W18E01_21770	COG1609	Transcriptional regulator
WP2W18E01_21780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E01_21790	COG1879	ABC-type sugar transport system periplasmic component
WP2W18E01_21800	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18E01_21810	COG1129	ABC transporter
WP2W18E01_21820	COG1869	D-ribose catabolic process
WP2W18E01_21830	COG0625	glutathione transferase activity
WP2W18E01_21860	COG0037	tRNA processing
WP2W18E01_21870	COG0589	response to stress
WP2W18E01_21880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18E01_21910	COG2217	Heavy metal translocating P-type atpase
WP2W18E01_21930	COG2010	Cytochrome c
WP2W18E01_21960	COG3278	Belongs to the heme-copper respiratory oxidase family
WP2W18E01_21980	COG1956	GAF domain-containing protein
WP2W18E01_21990	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP2W18E01_22010	COG0308	aminopeptidase N
WP2W18E01_22030	COG2902	Dehydrogenase
WP2W18E01_22040	COG0167	dihydroorotate dehydrogenase activity
WP2W18E01_22060	COG0116	Belongs to the methyltransferase superfamily
WP2W18E01_22060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2W18E01_22100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2W18E01_22110	COG1067	ATP-dependent peptidase activity
WP2W18E01_22240	COG3141	response to X-ray
WP2W18E01_22260	COG2995	paraquat-inducible protein a
WP2W18E01_22270	COG3008	intermembrane lipid transfer
WP2W18E01_22280	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP2W18E01_22280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18E01_22310	COG0084	hydrolase, TatD family'
WP2W18E01_22320	COG0470	DNA polymerase III
WP2W18E01_22330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP2W18E01_22340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP2W18E01_22350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP2W18E01_22360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2W18E01_22370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP2W18E01_22380	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E01_22400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP2W18E01_22410	COG0416	fatty acid biosynthetic process
WP2W18E01_22420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP2W18E01_22430	COG1399	metal-binding, possibly nucleic acid-binding protein
WP2W18E01_22460	COG0564	pseudouridine synthase activity
WP2W18E01_22470	COG1530	ribonuclease E activity
WP2W18E01_22480	COG0306	phosphate transporter
WP2W18E01_22490	COG0717	Belongs to the dCTP deaminase family
WP2W18E01_22500	COG0572	uridine kinase
WP2W18E01_22510	COG0489	protein tyrosine kinase activity
WP2W18E01_22520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E01_22520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E01_22530	COG0625	glutathione transferase activity
WP2W18E01_22540	COG1254	Belongs to the acylphosphatase family
WP2W18E01_22550	COG0840	transmembrane signaling receptor activity
WP2W18E01_22560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2W18E01_22580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
WP2W18E01_22610	COG0709	Synthesizes selenophosphate from selenide and ATP
WP2W18E01_22620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP2W18E01_22630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18E01_22640	COG3437	response regulator, receiver
WP2W18E01_22660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP2W18E01_22680	COG1643	Atp-dependent helicase
WP2W18E01_22690	COG0517	IMP dehydrogenase activity
WP2W18E01_22690	COG0617	tRNA 3'-terminal CCA addition
WP2W18E01_22690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2W18E01_22700	COG2197	response regulator
WP2W18E01_22730	COG0583	DNA-binding transcription factor activity
WP2W18E01_22740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP2W18E01_22760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP2W18E01_22770	COG2832	Protein of unknown function (DUF454)
WP2W18E01_22780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18E01_22800	COG0697	spore germination
WP2W18E01_22820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WP2W18E01_22830	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E01_22840	COG2267	carboxylic ester hydrolase activity
WP2W18E01_22860	COG1214	PFAM Peptidase M22, glycoprotease
WP2W18E01_22870	COG1199	ATP-dependent helicase activity
WP2W18E01_22890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP2W18E01_22900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP2W18E01_22910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP2W18E01_22920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2W18E01_22920	COG0131	Imidazoleglycerol-phosphate dehydratase
WP2W18E01_22930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP2W18E01_22940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP2W18E01_22950	COG3437	response regulator, receiver
WP2W18E01_22970	COG2198	Histidine kinase
WP2W18E01_22970	COG0784	Response regulator, receiver
WP2W18E01_22970	COG2205	protein histidine kinase activity
WP2W18E01_22980	COG0107	imidazoleglycerol-phosphate synthase activity
WP2W18E01_22990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP2W18E01_22990	COG0140	phosphoribosyl-ATP diphosphatase activity
WP2W18E01_23010	COG2378	regulation of single-species biofilm formation
WP2W18E01_23020	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E01_23030	COG3134	Outer membrane lipoprotein
WP2W18E01_23060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18E01_23100	COG4681	YaeQ
WP2W18E01_23120	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18E01_23120	COG1024	Enoyl-CoA hydratase
WP2W18E01_23130	COG0183	Belongs to the thiolase family
WP2W18E01_23140	COG0714	Associated with various cellular activities
WP2W18E01_23200	COG1595	DNA-templated transcription, initiation
WP2W18E01_23220	COG2067	long-chain fatty acid transport protein
WP2W18E01_23230	COG2067	long-chain fatty acid transport protein
WP2W18E01_23240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP2W18E01_23270	COG1301	dicarboxylic acid transport
WP2W18E01_23280	COG3123	guanosine phosphorylase activity
WP2W18E01_23290	COG1760	l-serine dehydratase
WP2W18E01_23300	COG1760	l-serine dehydratase
WP2W18E01_23310	COG2951	lytic endotransglycosylase activity
WP2W18E01_23320	COG3100	YcgL domain-containing protein
WP2W18E01_23330	COG0850	regulation of cytokinetic process
WP2W18E01_23340	COG2894	cell division
WP2W18E01_23350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP2W18E01_23360	COG3099	Belongs to the UPF0263 family
WP2W18E01_23370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2W18E01_23400	COG2996	Protein conserved in bacteria
WP2W18E01_23450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18E01_23460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18E01_23470	COG0697	spore germination
WP2W18E01_23480	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP2W18E01_23490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E01_23520	COG0307	riboflavin synthase, alpha
WP2W18E01_23540	COG0534	Mate efflux family protein
WP2W18E01_23550	COG0417	DNA replication proofreading
WP2W18E01_23580	COG1560	Kdo2-lipid A biosynthetic process
WP2W18E01_23590	COG1560	Kdo2-lipid A biosynthetic process
WP2W18E01_23610	COG0583	DNA-binding transcription factor activity
WP2W18E01_23620	COG0673	inositol 2-dehydrogenase activity
WP2W18E01_23630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP2W18E01_23680	COG0583	DNA-binding transcription factor activity
WP2W18E01_23700	COG2723	6-phospho-beta-galactosidase activity
WP2W18E01_23710	COG0583	DNA-binding transcription factor activity
WP2W18E01_23730	COG0243	molybdopterin cofactor binding
WP2W18E01_23740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP2W18E01_23770	COG0583	DNA-binding transcription factor activity
WP2W18E01_23780	COG1879	ABC-type sugar transport system periplasmic component
WP2W18E01_23790	COG1129	ABC transporter
WP2W18E01_23800	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18E01_23810	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18E01_23850	COG0730	response to heat
WP2W18E01_23870	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E01_23890	COG1024	Enoyl-CoA hydratase
WP2W18E01_23900	COG1024	Enoyl-CoA hydratase
WP2W18E01_23910	COG1960	acyl-CoA dehydrogenase activity
WP2W18E01_23930	COG1960	acyl-CoA dehydrogenase activity
WP2W18E01_23940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP2W18E01_23950	COG1024	Enoyl-CoA hydratase
WP2W18E01_24020	COG1584	GPR1 FUN34 yaaH family protein
WP2W18E01_24030	COG3228	Belongs to the MtfA family
WP2W18E01_24050	COG1115	amino acid carrier protein
WP2W18E01_24060	COG1024	Enoyl-CoA hydratase
WP2W18E01_24090	COG3162	membrane
WP2W18E01_24100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18E01_24110	COG0488	(ABC) transporter
WP2W18E01_24120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18E01_24130	COG0776	regulation of translation
WP2W18E01_24140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2W18E01_24150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP2W18E01_24160	COG0740	serine-type endopeptidase activity
WP2W18E01_24170	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP2W18E01_24190	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP2W18E01_24200	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2W18E01_24210	COG1136	(ABC) transporter
WP2W18E01_24220	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2W18E01_24240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP2W18E01_24250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP2W18E01_24260	COG4166	transmembrane transport
WP2W18E01_24270	COG0697	spore germination
WP2W18E01_24290	COG2062	phosphohistidine phosphatase, SixA
WP2W18E01_24310	COG0500	methyltransferase
WP2W18E01_24330	COG1846	Transcriptional regulator
WP2W18E01_24370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP2W18E01_24380	COG2801	Transposase and inactivated derivatives
WP2W18E01_24400	COG5433	transposase activity
WP2W18E01_24430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18E01_24430	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18E01_24440	COG0517	IMP dehydrogenase activity
WP2W18E01_24440	COG0516	GMP reductase activity
WP2W18E01_24460	COG1874	Beta-galactosidase
WP2W18E01_24460	COG0366	Alpha amylase catalytic
WP2W18E01_24510	COG1570	exodeoxyribonuclease VII activity
WP2W18E01_24530	COG2885	chlorophyll binding
WP2W18E01_24570	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP2W18E01_24590	COG3768	UPF0283 membrane protein
WP2W18E01_24600	COG3106	COG3106 Predicted ATPase
WP2W18E01_24630	COG1842	Phage shock protein A
WP2W18E01_24640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP2W18E01_24670	COG4171	peptide transport system, permease
WP2W18E01_24700	COG4172	Belongs to the ABC transporter superfamily
WP2W18E01_24720	COG1609	Transcriptional regulator
WP2W18E01_24730	COG1263	PTS System
WP2W18E01_24730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_24740	COG2723	6-phospho-beta-galactosidase activity
WP2W18E01_24750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP2W18E01_24760	COG1286	toxin biosynthetic process
WP2W18E01_24770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP2W18E01_24780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP2W18E01_24790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP2W18E01_24800	COG0531	amino acid
WP2W18E01_24800	COG1674	ftsk spoiiie
WP2W18E01_24820	COG0686	Belongs to the AlaDH PNT family
WP2W18E01_24830	COG0492	ferredoxin-NADP+ reductase activity
WP2W18E01_24840	COG3706	GGDEF domain
WP2W18E01_24850	COG3134	Outer membrane lipoprotein
WP2W18E01_24860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP2W18E01_24870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP2W18E01_24880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP2W18E01_24890	COG0542	response to heat
WP2W18E01_24900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP2W18E01_24910	COG1278	Cold shock
WP2W18E01_24920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2W18E01_24960	COG1944	ATP diphosphatase activity
WP2W18E01_24970	COG2116	formate transmembrane transporter activity
WP2W18E01_24980	COG1882	Formate acetyltransferase
WP2W18E01_24990	COG2983	Belongs to the UPF0260 family
WP2W18E01_25020	COG2801	Transposase and inactivated derivatives
WP2W18E01_25040	COG2801	Transposase and inactivated derivatives
WP2W18E01_25050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WP2W18E01_25060	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2W18E01_25070	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18E01_25080	COG0567	Dehydrogenase, E1 component
WP2W18E01_25110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP2W18E01_25120	COG2009	succinate dehydrogenase
WP2W18E01_25160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2W18E01_25170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18E01_25170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP2W18E01_25190	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2W18E01_25220	COG1451	nucleotide metabolic process
WP2W18E01_25250	COG0254	rRNA binding
WP2W18E01_25260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP2W18E01_25280	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18E01_25290	COG1129	ABC transporter
WP2W18E01_25300	COG1879	ABC-type sugar transport system periplasmic component
WP2W18E01_25310	COG1069	ribulokinase activity
WP2W18E01_25330	COG2160	L-arabinose isomerase activity
WP2W18E01_25340	COG0583	DNA-binding transcription factor activity
WP2W18E01_25350	COG0436	Aminotransferase
WP2W18E01_25360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18E01_25390	COG0392	lysyltransferase activity
WP2W18E01_25390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP2W18E01_25400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2W18E01_25420	COG0469	pyruvate kinase activity
WP2W18E01_25440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_25440	COG1263	PTS System
WP2W18E01_25450	COG1874	Beta-galactosidase
WP2W18E01_25460	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WP2W18E01_25470	COG3833	ABC-type maltose transport systems, permease component
WP2W18E01_25480	COG1175	transmembrane transport
WP2W18E01_25490	COG2182	Extracellular solute-binding protein
WP2W18E01_25540	COG4580	involved in the transport of maltose and maltodextrins
WP2W18E01_25550	COG1609	Transcriptional regulator
WP2W18E01_25560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18E01_25570	COG1085	galactose-1-phosphate uridylyltransferase
WP2W18E01_25640	COG0300	oxidoreductase activity
WP2W18E01_25650	COG2801	Transposase and inactivated derivatives
WP2W18E01_25660	COG2963	transposase activity
WP2W18E01_25680	COG2925	Exonuclease
WP2W18E01_25700	COG3345	alpha-galactosidase
WP2W18E01_25710	COG1380	Effector of murein hydrolase LrgA
WP2W18E01_25720	COG1346	cytolysis
WP2W18E01_25730	COG0295	cytidine deaminase activity
WP2W18E01_25750	COG1022	Amp-dependent synthetase and ligase
WP2W18E01_25780	COG0861	Integral membrane protein TerC family
WP2W18E01_25790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18E01_25800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP2W18E01_25810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP2W18E01_25890	COG4771	TonB-dependent receptor
WP2W18E01_25900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18E01_25910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18E01_25920	COG1120	ATPase activity
WP2W18E01_25950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18E01_25970	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E01_25980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18E01_25990	COG1535	isochorismatase
WP2W18E01_25990	COG3433	isochorismatase activity
WP2W18E01_26000	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP2W18E01_26050	COG5001	Diguanylate cyclase
WP2W18E01_26050	COG3300	MHYT domain
WP2W18E01_26080	COG0840	transmembrane signaling receptor activity
WP2W18E01_26090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E01_26100	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP2W18E01_26110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP2W18E01_26120	COG0563	adenylate kinase activity
WP2W18E01_26130	COG0326	Molecular chaperone. Has ATPase activity
WP2W18E01_26150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP2W18E01_26180	COG3158	transport of potassium into the cell
WP2W18E01_26190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP2W18E01_26200	COG0298	carbon dioxide binding
WP2W18E01_26220	COG0309	Hydrogenase expression formation protein (HypE)
WP2W18E01_26230	COG0375	protein maturation
WP2W18E01_26250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP2W18E01_26260	COG1124	(ABC) transporter
WP2W18E01_26270	COG0444	Belongs to the ABC transporter superfamily
WP2W18E01_26280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18E01_26380	COG5433	transposase activity
WP2W18E01_26580	COG2771	luxR family
WP2W18E01_26600	COG0811	peptide transport
WP2W18E01_26610	COG0811	peptide transport
WP2W18E01_26620	COG0848	biopolymer transport protein
WP2W18E01_26630	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP2W18E01_26660	COG0402	S-adenosylhomocysteine deaminase activity
WP2W18E01_26670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP2W18E01_26690	COG3165	ubiquinone biosynthetic process from chorismate
WP2W18E01_26700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP2W18E01_26710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18E01_26720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18E01_26730	COG0805	protein transport
WP2W18E01_26740	COG0084	hydrolase, TatD family'
WP2W18E01_26780	COG0742	ribosomal rna small subunit methyltransferase
WP2W18E01_26800	COG0248	Ppx GppA phosphatase
WP2W18E01_26810	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_26820	COG3118	belongs to the thioredoxin family
WP2W18E01_26850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP2W18E01_26870	COG2960	long-chain fatty acid transporting porin activity
WP2W18E01_26900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18E01_26980	COG1609	Transcriptional regulator
WP2W18E01_26990	COG3604	Transcriptional regulator
WP2W18E01_27000	COG0426	domain, Protein
WP2W18E01_27000	COG1773	rubredoxin
WP2W18E01_27010	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E01_27030	COG0348	domain, Protein
WP2W18E01_27040	COG3033	Beta-eliminating lyase
WP2W18E01_27050	COG0814	amino acid
WP2W18E01_27060	COG0814	amino acid
WP2W18E01_27100	COG4251	negative regulation of phosphorylation
WP2W18E01_27100	COG5001	Diguanylate cyclase
WP2W18E01_27100	COG3706	GGDEF domain
WP2W18E01_27100	COG2203	Gaf domain
WP2W18E01_27110	COG3385	transposase activity
WP2W18E01_27140	COG0751	glycine-tRNA ligase activity
WP2W18E01_27150	COG0752	glycyl-tRNA synthetase alpha subunit
WP2W18E01_27160	COG2818	Glycosylase
WP2W18E01_27170	COG1335	isochorismatase
WP2W18E01_27190	COG2885	chlorophyll binding
WP2W18E01_27200	COG0251	oxidation-reduction process
WP2W18E01_27210	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18E01_27220	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18E01_27260	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_27270	COG0183	Belongs to the thiolase family
WP2W18E01_27280	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18E01_27280	COG1024	Enoyl-CoA hydratase
WP2W18E01_27290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18E01_27300	COG0006	proline dipeptidase activity
WP2W18E01_27310	COG1739	Uncharacterized protein family UPF0029
WP2W18E01_27320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18E01_27330	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP2W18E01_27350	COG1042	CoA-binding domain protein
WP2W18E01_27350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18E01_27350	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2W18E01_27370	COG0583	DNA-binding transcription factor activity
WP2W18E01_27380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP2W18E01_27390	COG0166	Belongs to the GPI family
WP2W18E01_27410	COG0668	transmembrane transport
WP2W18E01_27420	COG1309	transcriptional regulator
WP2W18E01_27430	COG0756	dUTP diphosphatase activity
WP2W18E01_27440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP2W18E01_27450	COG2003	Belongs to the UPF0758 family
WP2W18E01_27460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP2W18E01_27470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP2W18E01_27490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP2W18E01_27500	COG2990	Protein conserved in bacteria
WP2W18E01_27510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP2W18E01_27520	COG0859	PFAM glycosyl transferase family 9
WP2W18E01_27530	COG0463	Glycosyl transferase, family 2
WP2W18E01_27540	COG0859	PFAM glycosyl transferase family 9
WP2W18E01_27550	COG1519	Transferase
WP2W18E01_27570	COG1561	YicC-like family, N-terminal region
WP2W18E01_27580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP2W18E01_27590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP2W18E01_27620	COG5001	Diguanylate cyclase
WP2W18E01_27620	COG2203	Gaf domain
WP2W18E01_27620	COG4251	negative regulation of phosphorylation
WP2W18E01_27620	COG3706	GGDEF domain
WP2W18E01_27630	COG3084	Protein conserved in bacteria
WP2W18E01_27650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP2W18E01_27660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2W18E01_27680	COG1335	isochorismatase
WP2W18E01_27700	COG1683	Conserved Protein
WP2W18E01_27710	COG0204	Acyl-transferase
WP2W18E01_27720	COG0204	Acyl-transferase
WP2W18E01_27730	COG0606	chelatase, subunit chli
WP2W18E01_27750	COG3978	acetolactate synthase activity
WP2W18E01_27770	COG0129	dihydroxy-acid dehydratase activity
WP2W18E01_27810	COG1309	transcriptional regulator
WP2W18E01_27820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP2W18E01_27830	COG0254	rRNA binding
WP2W18E01_27840	COG0702	epimerase
WP2W18E01_27850	COG0281	malic enzyme
WP2W18E01_27870	COG2205	protein histidine kinase activity
WP2W18E01_27880	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_27890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18E01_27920	COG0366	Alpha amylase catalytic
WP2W18E01_27950	COG0443	Heat shock 70 kDa protein
WP2W18E01_27960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2W18E01_27970	COG3045	CreA protein
WP2W18E01_28010	COG0174	glutamine synthetase
WP2W18E01_28050	COG3842	ATPase activity
WP2W18E01_28060	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2W18E01_28070	COG1177	transmembrane transport
WP2W18E01_28080	COG2258	MOSC domain
WP2W18E01_28100	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18E01_28110	COG0514	ATP-dependent DNA helicase (RecQ)
WP2W18E01_28130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP2W18E01_28150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP2W18E01_28160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18E01_28170	COG2239	Acts as a magnesium transporter
WP2W18E01_28180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18E01_28180	COG1648	precorrin-2 dehydrogenase activity
WP2W18E01_28190	COG2116	formate transmembrane transporter activity
WP2W18E01_28210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E01_28220	COG0842	Transport permease protein
WP2W18E01_28230	COG0842	Transport permease protein
WP2W18E01_28240	COG1131	(ABC) transporter
WP2W18E01_28250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_28290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP2W18E01_28300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP2W18E01_28340	COG1595	DNA-templated transcription, initiation
WP2W18E01_28350	COG3806	Anti-sigma factor
WP2W18E01_28360	COG1968	undecaprenyl-diphosphatase activity
WP2W18E01_28370	COG0667	Aldo Keto reductase
WP2W18E01_28380	COG2017	converts alpha-aldose to the beta-anomer
WP2W18E01_28390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP2W18E01_28410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18E01_28420	COG1609	Transcriptional regulator
WP2W18E01_28430	COG3250	beta-galactosidase activity
WP2W18E01_28510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP2W18E01_28520	COG1288	antiporter activity
WP2W18E01_28540	COG1438	arginine binding
WP2W18E01_28550	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP2W18E01_28560	COG0540	Belongs to the ATCase OTCase family
WP2W18E01_28620	COG3040	lipid binding
WP2W18E01_28630	COG2207	Transcriptional regulator
WP2W18E01_28640	COG1979	alcohol dehydrogenase
WP2W18E01_28650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP2W18E01_28660	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP2W18E01_28670	COG2964	Protein conserved in bacteria
WP2W18E01_28680	COG3681	Belongs to the UPF0597 family
WP2W18E01_28690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18E01_28700	COG0564	pseudouridine synthase activity
WP2W18E01_28720	COG0542	response to heat
WP2W18E01_28730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2W18E01_28740	COG2502	aspartate--ammonia ligase
WP2W18E01_28750	COG1522	sequence-specific DNA binding
WP2W18E01_28770	COG0517	IMP dehydrogenase activity
WP2W18E01_28770	COG0516	GMP reductase activity
WP2W18E01_28810	COG2205	protein histidine kinase activity
WP2W18E01_28830	COG2204	response regulator
WP2W18E01_28860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP2W18E01_28900	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_28930	COG0243	molybdopterin cofactor binding
WP2W18E01_28940	COG3005	denitrification pathway
WP2W18E01_28950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP2W18E01_28960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18E01_28970	COG0569	domain protein
WP2W18E01_28980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP2W18E01_29010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18E01_29030	COG0250	Participates in transcription elongation, termination and antitermination
WP2W18E01_29040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP2W18E01_29050	COG0081	regulation of translation
WP2W18E01_29060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP2W18E01_29070	COG0222	ribosome binding
WP2W18E01_29080	COG0085	RNA polymerase activity
WP2W18E01_29090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP2W18E01_29100	COG2964	Protein conserved in bacteria
WP2W18E01_29110	COG0251	oxidation-reduction process
WP2W18E01_29120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2W18E01_29140	COG2168	tRNA wobble position uridine thiolation
WP2W18E01_29150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP2W18E01_29160	COG0049	tRNA binding
WP2W18E01_29170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP2W18E01_29180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18E01_29190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2W18E01_29200	COG2801	Transposase and inactivated derivatives
WP2W18E01_29240	COG2252	PERMEase
WP2W18E01_29250	COG2376	Dihydroxyacetone kinase
WP2W18E01_29260	COG1461	Dihydroxyacetone kinase
WP2W18E01_29290	COG0583	DNA-binding transcription factor activity
WP2W18E01_29300	COG2957	Belongs to the agmatine deiminase family
WP2W18E01_29330	COG2957	Belongs to the agmatine deiminase family
WP2W18E01_29350	COG0628	permease
WP2W18E01_29360	COG0494	nUDIX hydrolase
WP2W18E01_29400	COG0753	catalase activity
WP2W18E01_29410	COG0456	acetyltransferase
WP2W18E01_29470	COG3842	ATPase activity
WP2W18E01_29490	COG1175	transmembrane transport
WP2W18E01_29550	COG0583	DNA-binding transcription factor activity
WP2W18E01_29570	COG1741	Belongs to the pirin family
WP2W18E01_29580	COG2259	Doxx family
WP2W18E01_29590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP2W18E01_29600	COG1074	ATP-dependent DNA helicase activity
WP2W18E01_29610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2W18E01_29640	COG2801	Transposase and inactivated derivatives
WP2W18E01_29650	COG0346	lactoylglutathione lyase activity
WP2W18E01_29670	COG0004	ammonium transporteR
WP2W18E01_29680	COG0347	Belongs to the P(II) protein family
WP2W18E01_29690	COG3706	GGDEF domain
WP2W18E01_29730	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_29740	COG2205	protein histidine kinase activity
WP2W18E01_29750	COG1278	Cold shock
WP2W18E01_29850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2W18E01_29910	COG2197	response regulator
WP2W18E01_29920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP2W18E01_29940	COG3047	cAMP biosynthetic process
WP2W18E01_30000	COG3135	benzoate transporter
WP2W18E01_30010	COG1396	sequence-specific DNA binding
WP2W18E01_30040	COG2926	Belongs to the UPF0265 family
WP2W18E01_30060	COG3028	Belongs to the UPF0307 family
WP2W18E01_30070	COG0312	modulator of DNA gyrase
WP2W18E01_30090	COG3071	HemY protein
WP2W18E01_30100	COG2959	enzyme of heme biosynthesis
WP2W18E01_30120	COG0181	hydroxymethylbilane synthase activity
WP2W18E01_30130	COG3072	Adenylate cyclase
WP2W18E01_30140	COG0400	carboxylic ester hydrolase activity
WP2W18E01_30150	COG1965	Belongs to the frataxin family
WP2W18E01_30160	COG0019	diaminopimelate decarboxylase activity
WP2W18E01_30170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP2W18E01_30200	COG1011	Hydrolase
WP2W18E01_30220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP2W18E01_30230	COG0561	phosphatase activity
WP2W18E01_30250	COG1988	membrane-bound metal-dependent
WP2W18E01_30260	COG1546	Belongs to the CinA family
WP2W18E01_30260	COG1058	Belongs to the CinA family
WP2W18E01_30280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP2W18E01_30300	COG1522	sequence-specific DNA binding
WP2W18E01_30310	COG1368	sulfuric ester hydrolase activity
WP2W18E01_30340	COG1285	pathogenesis
WP2W18E01_30380	COG4221	oxidoreductase activity
WP2W18E01_30410	COG1979	alcohol dehydrogenase
WP2W18E01_30430	COG2873	o-acetylhomoserine
WP2W18E01_30490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP2W18E01_30510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP2W18E01_30520	COG2949	membrane
WP2W18E01_30530	COG3291	Pkd domain containing protein
WP2W18E01_30540	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E01_30550	COG1441	menaquinone biosynthetic process
WP2W18E01_30560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP2W18E01_30570	COG0596	Alpha beta hydrolase
WP2W18E01_30580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP2W18E01_30590	COG1169	isochorismate synthase
WP2W18E01_30600	COG1575	Belongs to the MenA family. Type 1 subfamily
WP2W18E01_30640	COG0513	Belongs to the DEAD box helicase family
WP2W18E01_30650	COG5433	transposase activity
WP2W18E01_30660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18E01_30690	COG1671	Belongs to the UPF0178 family
WP2W18E01_30750	COG3722	fumarate hydratase activity
WP2W18E01_30760	COG0246	Mannitol dehydrogenase
WP2W18E01_30770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E01_30770	COG2213	PTS system mannitol-specific
WP2W18E01_30780	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP2W18E01_30810	COG2771	luxR family
WP2W18E01_30840	COG1560	Kdo2-lipid A biosynthetic process
WP2W18E01_30850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP2W18E01_30850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP2W18E01_30860	COG1538	Outer membrane efflux protein
WP2W18E01_30870	COG0494	nUDIX hydrolase
WP2W18E01_30880	COG3151	Protein conserved in bacteria
WP2W18E01_30900	COG3150	esterase
WP2W18E01_30910	COG1051	belongs to the nudix hydrolase family
WP2W18E01_30940	COG1566	PFAM secretion protein HlyD family protein
WP2W18E01_30950	COG1289	transmembrane transporter activity
WP2W18E01_31050	COG0484	heat shock protein binding
WP2W18E01_31070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18E01_31110	COG0204	Acyl-transferase
WP2W18E01_31120	COG1842	Phage shock protein A
WP2W18E01_31150	COG2827	Endonuclease containing a URI domain
WP2W18E01_31160	COG2962	Rard protein
WP2W18E01_31170	COG1573	uracil-dna glycosylase
WP2W18E01_31190	COG0583	DNA-binding transcription factor activity
WP2W18E01_31200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP2W18E01_31210	COG1121	(ABC) transporter
WP2W18E01_31220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP2W18E01_31260	COG0739	heme binding
WP2W18E01_31280	COG3068	Protein conserved in bacteria
WP2W18E01_31340	COG1522	sequence-specific DNA binding
WP2W18E01_31350	COG0110	maltose O-acetyltransferase activity
WP2W18E01_31360	COG0366	Alpha amylase catalytic
WP2W18E01_31370	COG1263	PTS System
WP2W18E01_31370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_31410	COG0252	asparaginase activity
WP2W18E01_31440	COG1803	Methylglyoxal synthase
WP2W18E01_31480	COG1444	tRNA N-acetyltransferase activity
WP2W18E01_31490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP2W18E01_31490	COG1565	acr, cog1565
WP2W18E01_31510	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WP2W18E01_31570	COG0109	protoheme IX farnesyltransferase activity
WP2W18E01_31580	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_31590	COG1177	transmembrane transport
WP2W18E01_31600	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2W18E01_31610	COG3842	ATPase activity
WP2W18E01_31620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP2W18E01_31630	COG0583	DNA-binding transcription factor activity
WP2W18E01_31640	COG1757	Na H antiporter
WP2W18E01_31670	COG0297	glycogen (starch) synthase activity
WP2W18E01_31680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP2W18E01_31690	COG2813	Specifically methylates the guanine in position
WP2W18E01_31700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18E01_31710	COG4251	negative regulation of phosphorylation
WP2W18E01_31710	COG5001	Diguanylate cyclase
WP2W18E01_31710	COG3706	GGDEF domain
WP2W18E01_31710	COG2203	Gaf domain
WP2W18E01_31720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E01_31740	COG2995	paraquat-inducible protein a
WP2W18E01_31750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2W18E01_31750	COG3008	intermembrane lipid transfer
WP2W18E01_31760	COG3009	Protein conserved in bacteria
WP2W18E01_31780	COG3240	lipase activity
WP2W18E01_31810	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP2W18E01_31820	COG1194	a g-specific adenine glycosylase
WP2W18E01_31840	COG3409	Peptidoglycan-binding domain 1 protein
WP2W18E01_31840	COG3267	Type II secretory pathway component ExeA
WP2W18E01_31850	COG0617	tRNA 3'-terminal CCA addition
WP2W18E01_31860	COG0306	phosphate transporter
WP2W18E01_31870	COG1392	Phosphate transport regulator
WP2W18E01_31880	COG3025	triphosphatase activity
WP2W18E01_31890	COG3133	Outer membrane lipoprotein
WP2W18E01_31930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WP2W18E01_31940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP2W18E01_31960	COG3031	protein transport across the cell outer membrane
WP2W18E01_31980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2W18E01_31990	COG1459	type II secretion system
WP2W18E01_32000	COG2165	general secretion pathway protein
WP2W18E01_32020	COG2165	general secretion pathway protein
WP2W18E01_32030	COG4795	General secretion pathway protein
WP2W18E01_32040	COG3156	type II secretion system protein K
WP2W18E01_32060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP2W18E01_32090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2W18E01_32120	COG1011	Hydrolase
WP2W18E01_32130	COG0494	nUDIX hydrolase
WP2W18E01_32140	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP2W18E01_32150	COG0814	amino acid
WP2W18E01_32160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E01_32190	COG0626	cystathionine gamma-synthase activity
WP2W18E01_32200	COG0460	homoserine dehydrogenase
WP2W18E01_32200	COG0527	aspartate kinase activity
WP2W18E01_32210	COG1346	cytolysis
WP2W18E01_32220	COG1380	Effector of murein hydrolase LrgA
WP2W18E01_32230	COG0583	DNA-binding transcription factor activity
WP2W18E01_32300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP2W18E01_32320	COG3385	transposase activity
WP2W18E01_32330	COG5001	Diguanylate cyclase
WP2W18E01_32330	COG5002	protein histidine kinase activity
WP2W18E01_32330	COG3447	MASE1 domain protein
WP2W18E01_32340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP2W18E01_32360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP2W18E01_32370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2W18E01_32390	COG0137	argininosuccinate synthase activity
WP2W18E01_32400	COG0165	Argininosuccinate lyase
WP2W18E01_32410	COG0583	DNA-binding transcription factor activity
WP2W18E01_32430	COG1942	4-Oxalocrotonate Tautomerase
WP2W18E01_32490	COG0110	maltose O-acetyltransferase activity
WP2W18E01_32500	COG3174	membrane
WP2W18E01_32510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_32520	COG1126	abc transporter atp-binding protein
WP2W18E01_32530	COG0765	amino acid transport
WP2W18E01_32560	COG0765	amino acid transport
WP2W18E01_32570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2W18E01_32580	COG1505	serine-type exopeptidase activity
WP2W18E01_32600	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E01_32610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP2W18E01_32640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18E01_32650	COG4991	sh3 domain protein
WP2W18E01_32660	COG2816	NAD+ diphosphatase activity
WP2W18E01_32670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP2W18E01_32680	COG1940	carbohydrate kinase activity
WP2W18E01_32690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2W18E01_32700	COG0126	phosphoglycerate kinase activity
WP2W18E01_32720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18E01_32780	COG0583	DNA-binding transcription factor activity
WP2W18E01_32800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP2W18E01_32820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP2W18E01_32830	COG1595	DNA-templated transcription, initiation
WP2W18E01_32840	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP2W18E01_32870	COG0481	GTPase activity
WP2W18E01_32880	COG0681	Belongs to the peptidase S26 family
WP2W18E01_32890	COG0571	ribonuclease III activity
WP2W18E01_32910	COG1381	Involved in DNA repair and RecF pathway recombination
WP2W18E01_32920	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP2W18E01_32930	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP2W18E01_32940	COG4807	Protein conserved in bacteria
WP2W18E01_32960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18E01_32970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18E01_32980	COG3956	TIGRFAM MazG family protein
WP2W18E01_32990	COG0504	CTP synthase activity
WP2W18E01_33000	COG0148	phosphopyruvate hydratase activity
WP2W18E01_33010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP2W18E01_33020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP2W18E01_33040	COG0585	pseudouridine synthase activity
WP2W18E01_33050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP2W18E01_33060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP2W18E01_33070	COG1238	metal cluster binding
WP2W18E01_33080	COG1388	LysM domain
WP2W18E01_33080	COG4942	peptidase
WP2W18E01_33100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP2W18E01_33110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP2W18E01_33120	COG1610	YqeY-like protein
WP2W18E01_33130	COG0358	DNA primase activity
WP2W18E01_33140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP2W18E01_33200	COG0138	bifunctional purine biosynthesis protein purh
WP2W18E01_33220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WP2W18E01_33230	COG3036	rescue of stalled ribosome
WP2W18E01_33240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2W18E01_33250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP2W18E01_33270	COG0673	inositol 2-dehydrogenase activity
WP2W18E01_33290	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP2W18E01_33300	COG0330	HflC and HflK could
WP2W18E01_33310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18E01_33310	COG1648	precorrin-2 dehydrogenase activity
WP2W18E01_33320	COG0175	sulfate reduction
WP2W18E01_33330	COG2895	sulfate adenylyltransferase (ATP) activity
WP2W18E01_33340	COG0471	metal ion transport
WP2W18E01_33340	COG3273	potassium ion transport
WP2W18E01_33350	COG0529	Catalyzes the synthesis of activated sulfate
WP2W18E01_33400	COG0840	transmembrane signaling receptor activity
WP2W18E01_33460	COG1136	(ABC) transporter
WP2W18E01_33490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP2W18E01_33520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP2W18E01_33530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2W18E01_33540	COG0163	prenyltransferase activity
WP2W18E01_33570	COG1131	(ABC) transporter
WP2W18E01_33580	COG0842	Transport permease protein
WP2W18E01_33600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP2W18E01_33610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP2W18E01_33620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP2W18E01_33640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18E01_33650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP2W18E01_33660	COG1489	DNA binding
WP2W18E01_33680	COG1643	Atp-dependent helicase
WP2W18E01_33690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2W18E01_33700	COG0346	lactoylglutathione lyase activity
WP2W18E01_33720	COG2076	Multidrug Resistance protein
WP2W18E01_33730	COG0583	DNA-binding transcription factor activity
WP2W18E01_33750	COG0671	phosphoesterase, PA-phosphatase related
WP2W18E01_33790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP2W18E01_33800	COG0038	chloride channel
WP2W18E01_33820	COG0316	Belongs to the HesB IscA family
WP2W18E01_33830	COG2801	Transposase and inactivated derivatives
WP2W18E01_33850	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_33860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP2W18E01_33870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18E01_33890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_33950	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_33960	COG3104	oligopeptide transport
WP2W18E01_33970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP2W18E01_33980	COG1555	photosystem II stabilization
WP2W18E01_34000	COG2350	Protein conserved in bacteria
WP2W18E01_34010	COG2917	probably involved in intracellular septation
WP2W18E01_34020	COG0076	glutamate decarboxylase activity
WP2W18E01_34030	COG1272	protein, Hemolysin III
WP2W18E01_34040	COG0569	domain protein
WP2W18E01_34040	COG2985	domain, Protein
WP2W18E01_34080	COG0477	Major facilitator Superfamily
WP2W18E01_34090	COG0583	DNA-binding transcription factor activity
WP2W18E01_34100	COG3227	Zinc metalloprotease (Elastase)
WP2W18E01_34110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18E01_34120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18E01_34140	COG2731	YhcH YjgK YiaL family protein
WP2W18E01_34160	COG0668	transmembrane transport
WP2W18E01_34180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18E01_34210	COG0789	Transcriptional regulator
WP2W18E01_34230	COG5433	transposase activity
WP2W18E01_34300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP2W18E01_34320	COG0488	(ABC) transporter
WP2W18E01_34330	COG0516	GMP reductase activity
WP2W18E01_34330	COG0517	IMP dehydrogenase activity
WP2W18E01_34350	COG0835	chemotaxis
WP2W18E01_34350	COG0784	Response regulator, receiver
WP2W18E01_34360	COG2755	lipolytic protein G-D-S-L family
WP2W18E01_34370	COG4181	ATPase activity
WP2W18E01_34380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP2W18E01_34390	COG1090	epimerase
WP2W18E01_34400	COG2200	EAL domain
WP2W18E01_34410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E01_34420	COG4935	Belongs to the peptidase S8 family
WP2W18E01_34420	COG2234	aminopeptidase activity
WP2W18E01_34430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP2W18E01_34440	COG3171	Protein conserved in bacteria
WP2W18E01_34450	COG2066	Belongs to the glutaminase family
WP2W18E01_34460	COG2897	thiosulfate sulfurtransferase activity
WP2W18E01_34480	COG1132	(ABC) transporter
WP2W18E01_34520	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP2W18E01_34530	COG5001	Diguanylate cyclase
WP2W18E01_34530	COG3300	MHYT domain
WP2W18E01_34570	COG4628	conserved protein (DUF2132)
WP2W18E01_34580	COG0688	phosphatidylethanolamine metabolic process
WP2W18E01_34590	COG1162	GTPase activity
WP2W18E01_34600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP2W18E01_34610	COG1278	Cold shock
WP2W18E01_34630	COG0840	transmembrane signaling receptor activity
WP2W18E01_34640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18E01_34700	COG0848	biopolymer transport protein
WP2W18E01_34710	COG0811	peptide transport
WP2W18E01_34720	COG0811	peptide transport
WP2W18E01_34740	COG4206	TonB-dependent receptor
WP2W18E01_34750	COG4174	ABC transporter (Permease)
WP2W18E01_34760	COG4239	(ABC) transporter, permease
WP2W18E01_34780	COG0444	Belongs to the ABC transporter superfamily
WP2W18E01_34790	COG4608	Belongs to the ABC transporter superfamily
WP2W18E01_34810	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2W18E01_34820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP2W18E01_34860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP2W18E01_34920	COG0243	molybdopterin cofactor binding
WP2W18E01_34930	COG0243	molybdopterin cofactor binding
WP2W18E01_34940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18E01_34940	COG1648	precorrin-2 dehydrogenase activity
WP2W18E01_34960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E01_34960	COG1116	anion transmembrane transporter activity
WP2W18E01_34970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18E01_34980	COG1116	anion transmembrane transporter activity
WP2W18E01_34990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E01_34990	COG2146	nitrite reductase [NAD(P)H] activity
WP2W18E01_35000	COG2146	nitrite reductase [NAD(P)H] activity
WP2W18E01_35000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E01_35010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E01_35020	COG2313	pseudouridylate synthase activity
WP2W18E01_35070	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2W18E01_35090	COG2966	Psort location CytoplasmicMembrane, score
WP2W18E01_35110	COG3610	response to peptide
WP2W18E01_35130	COG4175	Glycine betaine
WP2W18E01_35140	COG4176	ABC-type proline glycine betaine transport system permease component
WP2W18E01_35150	COG2113	Glycine betaine
WP2W18E01_35160	COG0175	sulfate reduction
WP2W18E01_35170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E01_35180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP2W18E01_35190	COG0384	phenazine biosynthesis protein PhzF
WP2W18E01_35200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP2W18E01_35210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP2W18E01_35230	COG0786	glutamate:sodium symporter activity
WP2W18E01_35240	COG0252	asparaginase activity
WP2W18E01_35250	COG3139	Protein of unknown function (DUF1315)
WP2W18E01_35290	COG0616	signal peptide processing
WP2W18E01_35300	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E01_35300	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E01_35310	COG0778	Nitroreductase
WP2W18E01_35330	COG0110	maltose O-acetyltransferase activity
WP2W18E01_35340	COG2264	protein methyltransferase activity
WP2W18E01_35350	COG0604	alcohol dehydrogenase
WP2W18E01_35360	COG0583	DNA-binding transcription factor activity
WP2W18E01_35370	COG2190	(PTS) system
WP2W18E01_35370	COG1263	PTS System
WP2W18E01_35370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_35380	COG4145	pantothenate transmembrane transporter activity
WP2W18E01_35390	COG3924	membrane
WP2W18E01_35400	COG0439	Biotin carboxylase
WP2W18E01_35410	COG0511	ligase activity, forming carbon-carbon bonds
WP2W18E01_35420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP2W18E01_35430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18E01_35460	COG3381	protein complex oligomerization
WP2W18E01_35480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP2W18E01_35500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP2W18E01_35510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18E01_35510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18E01_35540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP2W18E01_35550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18E01_35560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP2W18E01_35570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP2W18E01_35580	COG4172	Belongs to the ABC transporter superfamily
WP2W18E01_35620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP2W18E01_35630	COG0142	geranyltranstransferase activity
WP2W18E01_35640	COG1722	exodeoxyribonuclease VII activity
WP2W18E01_35650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18E01_35660	COG1360	Flagellar Motor Protein
WP2W18E01_35690	COG1534	Rna-binding protein
WP2W18E01_35700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP2W18E01_35720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP2W18E01_35730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP2W18E01_35740	COG0149	triose-phosphate isomerase activity
WP2W18E01_35750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP2W18E01_35760	COG0779	Required for maturation of 30S ribosomal subunits
WP2W18E01_35770	COG0195	Participates in both transcription termination and antitermination
WP2W18E01_35780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP2W18E01_35790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP2W18E01_35800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP2W18E01_35810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP2W18E01_35820	COG1185	polyribonucleotide nucleotidyltransferase activity
WP2W18E01_35830	COG2211	Major facilitator Superfamily
WP2W18E01_35840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2W18E01_35850	COG1422	Protein of unknown function (DUF1090)
WP2W18E01_35870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18E01_35910	COG0312	modulator of DNA gyrase
WP2W18E01_35920	COG0312	modulator of DNA gyrase
WP2W18E01_35930	COG0312	modulator of DNA gyrase
WP2W18E01_35950	COG4974	Belongs to the 'phage' integrase family
WP2W18E01_35960	COG1970	mechanosensitive ion channel activity
WP2W18E01_35980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP2W18E01_35990	COG0789	Transcriptional regulator
WP2W18E01_36020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18E01_36040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP2W18E01_36060	COG0321	lipoyl(octanoyl) transferase activity
WP2W18E01_36070	COG2921	Belongs to the UPF0250 family
WP2W18E01_36080	COG1686	Belongs to the peptidase S11 family
WP2W18E01_36090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2W18E01_36100	COG2951	lytic endotransglycosylase activity
WP2W18E01_36110	COG0772	Belongs to the SEDS family
WP2W18E01_36120	COG0768	penicillin binding
WP2W18E01_36130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP2W18E01_36140	COG0799	negative regulation of ribosome biogenesis
WP2W18E01_36150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP2W18E01_36180	COG0495	leucyl-tRNA aminoacylation
WP2W18E01_36190	COG2888	peptidyl-tyrosine sulfation
WP2W18E01_36200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP2W18E01_36210	COG4535	Mg2 and Co2 transporter CorC
WP2W18E01_36220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP2W18E01_36230	COG1702	phosphate starvation-inducible protein PhoH
WP2W18E01_36240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2W18E01_36250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E01_36260	COG1335	isochorismatase
WP2W18E01_36290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E01_36320	COG2199	diguanylate cyclase activity
WP2W18E01_36340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2W18E01_36370	COG1464	Belongs to the NlpA lipoprotein family
WP2W18E01_36380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18E01_36390	COG2011	ABC-type metal ion transport system permease component
WP2W18E01_36400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP2W18E01_36420	COG0516	GMP reductase activity
WP2W18E01_36430	COG0189	ligase activity
WP2W18E01_36430	COG4067	protein conserved in archaea
WP2W18E01_36470	COG0300	oxidoreductase activity
WP2W18E01_36510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18E01_36520	COG3214	Protein conserved in bacteria
WP2W18E01_36550	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2W18E01_36560	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2W18E01_36570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP2W18E01_36580	COG1053	succinate dehydrogenase
WP2W18E01_36610	COG3264	Mechanosensitive ion channel
WP2W18E01_36610	COG1511	domain protein
WP2W18E01_36630	COG0739	heme binding
WP2W18E01_36660	COG0583	DNA-binding transcription factor activity
WP2W18E01_36690	COG0583	DNA-binding transcription factor activity
WP2W18E01_36700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP2W18E01_36760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP2W18E01_36770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP2W18E01_36790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP2W18E01_36800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP2W18E01_36810	COG0546	phosphoglycolate phosphatase activity
WP2W18E01_36820	COG0180	Tryptophanyl-tRNA synthetase
WP2W18E01_36850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP2W18E01_36870	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_36900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E01_36950	COG0471	metal ion transport
WP2W18E01_36950	COG0490	domain, Protein
WP2W18E01_36960	COG0012	GTP binding
WP2W18E01_36970	COG0193	aminoacyl-tRNA hydrolase activity
WP2W18E01_36980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP2W18E01_36990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP2W18E01_37000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP2W18E01_37010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP2W18E01_37020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP2W18E01_37030	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2W18E01_37050	COG2912	Transglutaminase-like superfamily
WP2W18E01_37060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP2W18E01_37070	COG1301	dicarboxylic acid transport
WP2W18E01_37090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP2W18E01_37120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP2W18E01_37130	COG1115	amino acid carrier protein
WP2W18E01_37170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP2W18E01_37190	COG0189	ligase activity
WP2W18E01_37200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP2W18E01_37220	COG3091	SprT-like family
WP2W18E01_37240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP2W18E01_37290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP2W18E01_37300	COG0739	heme binding
WP2W18E01_37310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2W18E01_37320	COG3408	Glycogen debranching enzyme
WP2W18E01_37320	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WP2W18E01_37340	COG1881	PFAM PEBP family protein
WP2W18E01_37360	COG0583	DNA-binding transcription factor activity
WP2W18E01_37380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP2W18E01_37400	COG0583	DNA-binding transcription factor activity
WP2W18E01_37410	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E01_37420	COG0616	signal peptide processing
WP2W18E01_37430	COG3724	N-succinylarginine dihydrolase activity
WP2W18E01_37470	COG0840	transmembrane signaling receptor activity
WP2W18E01_37490	COG2971	BadF BadG BcrA BcrD
WP2W18E01_37510	COG4608	Belongs to the ABC transporter superfamily
WP2W18E01_37520	COG0444	Belongs to the ABC transporter superfamily
WP2W18E01_37530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18E01_37560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2W18E01_37580	COG0640	Transcriptional regulator
WP2W18E01_37590	COG0798	PFAM Bile acid sodium symporter
WP2W18E01_37600	COG1393	Belongs to the ArsC family
WP2W18E01_37630	COG1677	Flagellar hook-basal body complex protein FliE
WP2W18E01_37650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP2W18E01_37760	COG1684	flagellar biosynthetic protein fliR
WP2W18E01_37780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP2W18E01_37830	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP2W18E01_37840	COG0784	Response regulator, receiver
WP2W18E01_37840	COG0643	Histidine kinase
WP2W18E01_37840	COG2198	Histidine kinase
WP2W18E01_37850	COG2201	protein-glutamate methylesterase activity
WP2W18E01_37860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18E01_37870	COG1360	Flagellar Motor Protein
WP2W18E01_37880	COG1192	Involved in chromosome partitioning
WP2W18E01_37900	COG0835	chemotaxis
WP2W18E01_37930	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18E01_37940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18E01_37950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18E01_37960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP2W18E01_37970	COG1138	Cytochrome C-type biogenesis protein
WP2W18E01_37980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18E01_38000	COG0457	Tetratricopeptide repeat
WP2W18E01_38030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP2W18E01_38040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18E01_38040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18E01_38060	COG2801	Transposase and inactivated derivatives
WP2W18E01_38130	COG0259	pyridoxamine-phosphate oxidase activity
WP2W18E01_38190	COG3153	acetyltransferase
WP2W18E01_38220	COG0800	Aldolase
WP2W18E01_38230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E01_38250	COG2721	sulfolactate sulfo-lyase activity
WP2W18E01_38260	COG0246	Mannitol dehydrogenase
WP2W18E01_38320	COG5433	transposase activity
WP2W18E01_38340	COG3311	Transcriptional regulator
WP2W18E01_38360	COG2801	Transposase and inactivated derivatives
WP2W18E01_38380	COG4974	Belongs to the 'phage' integrase family
WP2W18E01_38420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP2W18E01_38430	COG2867	negative regulation of translational initiation
WP2W18E01_38450	COG0702	epimerase
WP2W18E01_38460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18E01_38470	COG1454	alcohol dehydrogenase
WP2W18E01_38480	COG2932	Transcriptional regulator
WP2W18E01_38680	COG0640	Transcriptional regulator
WP2W18E01_38700	COG4373	Mu-like prophage FluMu protein gp28
WP2W18E01_38710	COG4383	Mu-like prophage protein gp29
WP2W18E01_38760	COG4388	Caudovirus prohead serine protease
WP2W18E01_38770	COG4397	Mu-like prophage major head subunit gpT
WP2W18E01_38940	COG0564	pseudouridine synthase activity
WP2W18E01_38950	COG1957	nucleoside hydrolase
WP2W18E01_39000	COG1280	lysine exporter protein (LysE YggA)
WP2W18E01_39020	COG3263	regulation of cellular component size
WP2W18E01_39040	COG1876	peptidase activity
WP2W18E01_39050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP2W18E01_39060	COG1393	Belongs to the ArsC family
WP2W18E01_39070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_39100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_39130	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2W18E01_39140	COG1473	amidohydrolase
WP2W18E01_39160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2W18E01_39170	COG0017	Asparaginyl-tRNA synthetase
WP2W18E01_39210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2W18E01_39220	COG0156	8-amino-7-oxononanoate synthase activity
WP2W18E01_39240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP2W18E01_39250	COG0501	Belongs to the peptidase M48B family
WP2W18E01_39260	COG0633	Ferredoxin
WP2W18E01_39260	COG3217	Mosc domain protein beta barrel domain protein
WP2W18E01_39260	COG3217	Mosc domain protein beta barrel domain protein
WP2W18E01_39260	COG0633	Ferredoxin
WP2W18E01_39280	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP2W18E01_39280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP2W18E01_39280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP2W18E01_39280	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP2W18E01_39290	COG2841	Protein conserved in bacteria
WP2W18E01_39310	COG0534	Mate efflux family protein
WP2W18E01_39380	COG1309	transcriptional regulator
WP2W18E01_39410	COG0791	NLP P60 protein
WP2W18E01_39420	COG0583	DNA-binding transcription factor activity
WP2W18E01_39460	COG0500	methyltransferase
WP2W18E01_39470	COG4106	trans-aconitate 2-methyltransferase activity
WP2W18E01_39480	COG1801	Protein of unknown function DUF72
WP2W18E01_39490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP2W18E01_39500	COG0217	transcriptional regulatory protein
WP2W18E01_39510	COG2194	sulfuric ester hydrolase activity
WP2W18E01_39520	COG1940	carbohydrate kinase activity
WP2W18E01_39520	COG1846	Transcriptional regulator
WP2W18E01_39530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2W18E01_39540	COG0363	glucosamine-6-phosphate deaminase activity
WP2W18E01_39550	COG1263	PTS System
WP2W18E01_39550	COG2190	(PTS) system
WP2W18E01_39550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18E01_39570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18E01_39580	COG0735	belongs to the Fur family
WP2W18E01_39600	COG0716	FMN binding
WP2W18E01_39630	COG0596	Alpha beta hydrolase
WP2W18E01_39640	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP2W18E01_39650	COG0033	Phosphoglucomutase
WP2W18E01_39670	COG1846	Transcriptional regulator
WP2W18E01_39680	COG2951	lytic endotransglycosylase activity
WP2W18E01_39690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP2W18E01_39700	COG4136	ATPase activity
WP2W18E01_39720	COG4134	Bacterial extracellular solute-binding protein
WP2W18E01_39730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E01_39740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2W18E01_39790	COG2801	Transposase and inactivated derivatives
WP2W18E01_39800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18E01_39820	COG2801	Transposase and inactivated derivatives
WP2W18E01_39840	COG0729	surface antigen
WP2W18E01_39850	COG2911	Protein conserved in bacteria
WP2W18E01_39870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP2W18E01_39890	COG0741	lytic transglycosylase activity
WP2W18E01_39920	COG1607	acyl-coa hydrolase
WP2W18E01_39950	COG1388	LysM domain
WP2W18E01_39950	COG0741	lytic transglycosylase activity
WP2W18E01_39960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18E01_39970	COG2226	methyltransferase
WP2W18E01_39980	COG0328	RNA-DNA hybrid ribonuclease activity
WP2W18E01_39990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E01_40010	COG0784	Response regulator, receiver
WP2W18E01_40010	COG3437	response regulator, receiver
WP2W18E01_40020	COG1960	acyl-CoA dehydrogenase activity
WP2W18E01_40030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2W18E01_40040	COG0121	glutamine amidotransferase
WP2W18E01_40060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WP2W18E01_40110	COG2197	response regulator
WP2W18E01_40120	COG3850	Histidine kinase
WP2W18E01_40130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP2W18E01_40140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18E01_40140	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18E01_40160	COG0243	molybdopterin cofactor binding
WP2W18E01_40170	COG0437	4 iron, 4 sulfur cluster binding
WP2W18E01_40180	COG0348	domain, Protein
WP2W18E01_40200	COG3005	denitrification pathway
WP2W18E01_40210	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2W18E01_40220	COG0315	cyclic pyranopterin monophosphate synthase activity
WP2W18E01_40230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP2W18E01_40240	COG0314	molybdopterin synthase activity
WP2W18E01_40270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP2W18E01_40280	COG2267	carboxylic ester hydrolase activity
WP2W18E01_40290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2W18E01_40310	COG0302	gtp cyclohydrolase
WP2W18E01_40320	COG0840	transmembrane signaling receptor activity
WP2W18E01_40330	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP2W18E01_40350	COG0583	DNA-binding transcription factor activity
WP2W18E01_40380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP2W18E01_40410	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2W18E01_40420	COG1166	arginine decarboxylase activity
WP2W18E01_40470	COG1403	HNH endonuclease
WP2W18E01_40500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP2W18E01_40510	COG1187	pseudouridine synthase activity
WP2W18E01_40520	COG2807	transmembrane transport
WP2W18E01_40540	COG0583	DNA-binding transcription factor activity
WP2W18E01_40580	COG2979	Protein of unknown function (DUF533)
WP2W18E01_40600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E01_40610	COG1271	oxidase subunit
WP2W18E01_40620	COG1294	oxidase, subunit
WP2W18E01_40640	COG2814	Major facilitator Superfamily
WP2W18E01_40650	COG0656	L-ascorbic acid biosynthetic process
WP2W18E01_40690	COG0583	DNA-binding transcription factor activity
WP2W18E01_40700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP2W18E01_40710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2W18E01_40720	COG2271	Major facilitator Superfamily
WP2W18E01_40730	COG1349	DNA-binding transcription factor activity
WP2W18E01_40750	COG0584	glycerophosphoryl diester phosphodiesterase
WP2W18E01_40760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18E01_40770	COG1605	Chorismate mutase
WP2W18E01_40770	COG0287	Prephenate dehydrogenase
WP2W18E01_40790	COG3085	chromosome segregation
WP2W18E01_40800	COG4574	serine-type endopeptidase inhibitor activity
WP2W18E01_40840	COG1770	oligopeptidase
WP2W18E01_40850	COG4771	TonB-dependent receptor
WP2W18E01_40860	COG3083	sulfuric ester hydrolase activity
WP2W18E01_40870	COG3082	Protein of unknown function (DUF1414)
WP2W18E01_40880	COG3081	Nucleoid-associated protein
WP2W18E01_40900	COG1175	transmembrane transport
WP2W18E01_40910	COG3833	ABC-type maltose transport systems, permease component
WP2W18E01_40920	COG3842	ATPase activity
WP2W18E01_40940	COG0596	Alpha beta hydrolase
WP2W18E01_40970	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18E01_40980	COG4783	chaperone-mediated protein folding
WP2W18E01_41000	COG1393	Belongs to the ArsC family
WP2W18E01_41040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_41050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2W18E01_41060	COG2431	L-lysine efflux transmembrane transporter activity
WP2W18E01_41080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E01_41100	COG4160	amino acid transport
WP2W18E01_41120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2W18E01_41140	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E01_41190	COG0628	permease
WP2W18E01_41210	COG2373	Large extracellular alpha-helical protein
WP2W18E01_41220	COG4953	penicillin-binding protein 1C
WP2W18E01_41240	COG0301	tRNA thio-modification
WP2W18E01_41240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18E01_41280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP2W18E01_41350	COG1083	cytidylyl-transferase
WP2W18E01_41370	COG2801	Transposase and inactivated derivatives
WP2W18E01_41400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WP2W18E01_41410	COG2089	acid synthase
WP2W18E01_41430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP2W18E01_41450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP2W18E01_41470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP2W18E01_41510	COG0346	lactoylglutathione lyase activity
WP2W18E01_41520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP2W18E01_41530	COG4660	Part of a membrane complex involved in electron transport
WP2W18E01_41540	COG4659	FMN binding
WP2W18E01_41550	COG4658	electron transport chain
WP2W18E01_41570	COG2878	Part of a membrane complex involved in electron transport
WP2W18E01_41580	COG4657	Part of a membrane complex involved in electron transport
WP2W18E01_41590	COG0697	spore germination
WP2W18E01_41630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP2W18E01_41650	COG1288	antiporter activity
WP2W18E01_41660	COG0436	Aminotransferase
WP2W18E01_41680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP2W18E01_41690	COG2027	D-alanyl-D-alanine carboxypeptidase
WP2W18E01_41700	COG1061	Type III restriction enzyme res subunit
WP2W18E01_41710	COG1566	PFAM secretion protein HlyD family protein
WP2W18E01_41730	COG3264	Mechanosensitive ion channel
WP2W18E01_41730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP2W18E01_41740	COG1966	Carbon starvation protein
WP2W18E01_41750	COG3279	Response regulator of the LytR AlgR family
WP2W18E01_41760	COG3275	phosphorelay sensor kinase activity
WP2W18E01_41780	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E01_41780	COG1454	alcohol dehydrogenase
WP2W18E01_41790	COG2095	MarC family integral membrane protein
WP2W18E01_41810	COG0601	transmembrane transport
WP2W18E01_41820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18E01_41830	COG0444	Belongs to the ABC transporter superfamily
WP2W18E01_41850	COG0861	Integral membrane protein TerC family
WP2W18E01_41860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18E01_41880	COG1301	dicarboxylic acid transport
WP2W18E01_41900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP2W18E01_41930	COG0537	adenosine 5'-monophosphoramidase activity
WP2W18E01_42000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18E01_42010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18E01_42040	COG2354	Protein conserved in bacteria
WP2W18E01_42070	COG1164	Oligoendopeptidase f
WP2W18E01_42080	COG3150	esterase
WP2W18E01_42090	COG1252	NADH dehydrogenase
WP2W18E01_42110	COG0393	Putative heavy-metal-binding
WP2W18E01_42120	COG1619	proteins homologs of microcin C7 resistance protein MccF
WP2W18E01_42130	COG1368	sulfuric ester hydrolase activity
WP2W18E01_42150	COG0527	aspartate kinase activity
WP2W18E01_42160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP2W18E01_42160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2W18E01_42170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18E01_42220	COG0583	DNA-binding transcription factor activity
WP2W18E01_42230	COG1620	l-lactate permease
WP2W18E01_42240	COG0247	lactate metabolic process
WP2W18E01_42250	COG1139	Iron-sulfur cluster binding protein
WP2W18E01_42320	COG1136	(ABC) transporter
WP2W18E01_42360	COG2814	Major facilitator Superfamily
WP2W18E01_42410	COG0672	)-iron permease
WP2W18E01_42480	COG2308	Evidence 4 Homologs of previously reported genes of
WP2W18E01_42520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18E01_42520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18E01_42560	COG0501	Belongs to the peptidase M48B family
WP2W18E01_42580	COG0582	viral genome integration into host DNA
WP2W18E01_42640	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18E01_42660	COG4974	Belongs to the 'phage' integrase family
WP2W18E01_42750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18E01_42760	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP2W18E01_42780	COG0437	4 iron, 4 sulfur cluster binding
WP2W18E01_42790	COG5557	Pfam Polysulphide reductase, NrfD
WP2W18E01_42800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP2W18E01_42810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP2W18E01_42820	COG1773	rubredoxin
WP2W18E01_42940	COG5433	transposase activity
WP2W18E01_43030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP2W18E01_43040	COG1349	DNA-binding transcription factor activity
WP2W18E01_43050	COG0745	RESPONSE REGULATOR receiver
WP2W18E01_43060	COG2205	protein histidine kinase activity
WP2W18E01_43080	COG4452	Inner membrane protein CreD
WP2W18E01_43090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP2W18E01_43100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP2W18E01_43110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP2W18E01_43120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP2W18E01_43130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP2W18E01_43140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP2W18E01_43150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP2W18E01_43170	COG0356	it plays a direct role in the translocation of protons across the membrane
WP2W18E01_43190	COG1475	DNA binding
WP2W18E01_43200	COG1192	Involved in chromosome partitioning
WP2W18E01_43210	COG0357	Ribosomal RNA small subunit methyltransferase G
WP2W18E01_43220	COG0445	tRNA wobble uridine modification
WP2W18E01_43230	COG0716	FMN binding
WP2W18E01_43240	COG4774	siderophore transport
WP2W18E01_43250	COG4615	Cyclic peptide transporter
WP2W18E01_43260	COG1120	ATPase activity
WP2W18E01_43270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP2W18E01_43290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP2W18E01_43300	COG0706	membrane insertase activity
WP2W18E01_43310	COG0594	ribonuclease P activity
WP2W18E01_43320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP2W18E01_P10020	COG1192	Involved in chromosome partitioning
WP2W18E01_P10040	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18E01_P10110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_P10170	COG5433	transposase activity
WP2W18E01_P10200	COG2801	Transposase and inactivated derivatives
WP2W18E01_P10230	COG1484	DNA-dependent DNA replication
WP2W18E01_P10240	COG4584	PFAM Integrase catalytic
WP2W18E01_P10250	COG5433	transposase activity
WP2W18E01_P10280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E01_P10320	COG1192	Involved in chromosome partitioning
WP2W18E01_P10340	COG2801	Transposase and inactivated derivatives
WP2W18E01_P10380	COG3039	Transposase
WP2W18E01_P10400	COG3039	Transposase
WP2W18E01_P10520	COG0675	Transposase, IS605 OrfB family
WP2W18E01_P10530	COG3385	transposase activity
WP2W18E01_P10540	COG0675	Transposase, IS605 OrfB family
WP2W18E01_P10610	COG4584	PFAM Integrase catalytic
WP2W18E01_P10620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18E01_P10640	COG5433	transposase activity
WP2W18E01_P10800	COG3344	reverse transcriptase
WP2W18E01_P10830	COG2003	Belongs to the UPF0758 family
WP2W18E01_P10910	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18E01_P11160	COG2801	Transposase and inactivated derivatives
WP2W18E01_P11180	COG2003	Belongs to the UPF0758 family
WP2W18E01_P11240	COG4584	PFAM Integrase catalytic
WP2W18E01_P11250	COG1484	DNA-dependent DNA replication