locus-tag	class	description
WP5W18E02_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP5W18E02_00020	COG0592	DNA-directed DNA polymerase activity
WP5W18E02_00060	COG2378	regulation of single-species biofilm formation
WP5W18E02_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
WP5W18E02_00080	COG3385	transposase activity
WP5W18E02_00090	COG0071	Belongs to the small heat shock protein (HSP20) family
WP5W18E02_00100	COG3977	Valine--pyruvate aminotransferase
WP5W18E02_00130	COG2814	Major facilitator Superfamily
WP5W18E02_00160	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_00170	COG2205	protein histidine kinase activity
WP5W18E02_00230	COG2801	Transposase and inactivated derivatives
WP5W18E02_00290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP5W18E02_00310	COG2801	Transposase and inactivated derivatives
WP5W18E02_00330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_00340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_00350	COG1309	transcriptional regulator
WP5W18E02_00370	COG0561	phosphatase activity
WP5W18E02_00380	COG2267	carboxylic ester hydrolase activity
WP5W18E02_00390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP5W18E02_00400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP5W18E02_00410	COG1758	RNA polymerase activity
WP5W18E02_00430	COG0859	PFAM glycosyl transferase family 9
WP5W18E02_00440	COG3642	lipopolysaccharide core region biosynthetic process
WP5W18E02_00520	COG0589	response to stress
WP5W18E02_00530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP5W18E02_00540	COG3706	GGDEF domain
WP5W18E02_00550	COG1528	Iron-storage protein
WP5W18E02_00560	COG2081	HI0933 family
WP5W18E02_00570	COG2223	nitrite transmembrane transporter activity
WP5W18E02_00580	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_00610	COG3039	Transposase
WP5W18E02_00620	COG2205	protein histidine kinase activity
WP5W18E02_00620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_00640	COG3275	phosphorelay sensor kinase activity
WP5W18E02_00660	COG3279	Response regulator of the LytR AlgR family
WP5W18E02_00670	COG2223	nitrite transmembrane transporter activity
WP5W18E02_00680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP5W18E02_00690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP5W18E02_00710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP5W18E02_00740	COG1042	CoA-binding domain protein
WP5W18E02_00740	COG0045	succinate-CoA ligase (ADP-forming) activity
WP5W18E02_00740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP5W18E02_00760	COG0583	DNA-binding transcription factor activity
WP5W18E02_00770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP5W18E02_00780	COG0166	Belongs to the GPI family
WP5W18E02_00800	COG0668	transmembrane transport
WP5W18E02_00810	COG1309	transcriptional regulator
WP5W18E02_00820	COG0756	dUTP diphosphatase activity
WP5W18E02_00830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP5W18E02_00840	COG2003	Belongs to the UPF0758 family
WP5W18E02_00850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP5W18E02_00860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP5W18E02_00880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP5W18E02_00890	COG2990	Protein conserved in bacteria
WP5W18E02_00900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP5W18E02_00910	COG0859	PFAM glycosyl transferase family 9
WP5W18E02_00920	COG0463	Glycosyl transferase, family 2
WP5W18E02_00930	COG0859	PFAM glycosyl transferase family 9
WP5W18E02_00940	COG1519	Transferase
WP5W18E02_00980	COG1561	YicC-like family, N-terminal region
WP5W18E02_00990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP5W18E02_01000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP5W18E02_01030	COG2203	Gaf domain
WP5W18E02_01030	COG5001	Diguanylate cyclase
WP5W18E02_01030	COG4251	negative regulation of phosphorylation
WP5W18E02_01030	COG3706	GGDEF domain
WP5W18E02_01040	COG3084	Protein conserved in bacteria
WP5W18E02_01060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP5W18E02_01070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP5W18E02_01080	COG3639	organic phosphonate transmembrane transporter activity
WP5W18E02_01090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WP5W18E02_01100	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
WP5W18E02_01120	COG1335	isochorismatase
WP5W18E02_01140	COG1683	Conserved Protein
WP5W18E02_01150	COG0204	Acyl-transferase
WP5W18E02_01160	COG0204	Acyl-transferase
WP5W18E02_01170	COG0606	chelatase, subunit chli
WP5W18E02_01190	COG3978	acetolactate synthase activity
WP5W18E02_01210	COG0129	dihydroxy-acid dehydratase activity
WP5W18E02_01250	COG1309	transcriptional regulator
WP5W18E02_01260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP5W18E02_01270	COG0254	rRNA binding
WP5W18E02_01280	COG0702	epimerase
WP5W18E02_01290	COG0281	malic enzyme
WP5W18E02_01310	COG2205	protein histidine kinase activity
WP5W18E02_01320	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_01330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP5W18E02_01360	COG0366	Alpha amylase catalytic
WP5W18E02_01390	COG0443	Heat shock 70 kDa protein
WP5W18E02_01400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP5W18E02_01410	COG3045	CreA protein
WP5W18E02_01450	COG0174	glutamine synthetase
WP5W18E02_01490	COG3842	ATPase activity
WP5W18E02_01500	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP5W18E02_01510	COG1177	transmembrane transport
WP5W18E02_01520	COG2258	MOSC domain
WP5W18E02_01540	COG2050	protein possibly involved in aromatic compounds catabolism
WP5W18E02_01550	COG0514	ATP-dependent DNA helicase (RecQ)
WP5W18E02_01570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP5W18E02_01590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP5W18E02_01600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP5W18E02_01620	COG2239	Acts as a magnesium transporter
WP5W18E02_01630	COG1648	precorrin-2 dehydrogenase activity
WP5W18E02_01630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP5W18E02_01640	COG2116	formate transmembrane transporter activity
WP5W18E02_01660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP5W18E02_01670	COG0842	Transport permease protein
WP5W18E02_01680	COG0842	Transport permease protein
WP5W18E02_01690	COG1131	(ABC) transporter
WP5W18E02_01700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_01740	COG0477	Major facilitator Superfamily
WP5W18E02_01750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP5W18E02_01760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP5W18E02_01790	COG0018	arginyl-trna synthetase
WP5W18E02_01810	COG1595	DNA-templated transcription, initiation
WP5W18E02_01820	COG3806	Anti-sigma factor
WP5W18E02_01830	COG1968	undecaprenyl-diphosphatase activity
WP5W18E02_01840	COG0667	Aldo Keto reductase
WP5W18E02_01850	COG2017	converts alpha-aldose to the beta-anomer
WP5W18E02_01860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP5W18E02_01880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP5W18E02_01890	COG1609	Transcriptional regulator
WP5W18E02_01900	COG3250	beta-galactosidase activity
WP5W18E02_01980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP5W18E02_01990	COG1288	antiporter activity
WP5W18E02_02000	COG1438	arginine binding
WP5W18E02_02010	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP5W18E02_02020	COG0540	Belongs to the ATCase OTCase family
WP5W18E02_02090	COG3040	lipid binding
WP5W18E02_02100	COG2207	Transcriptional regulator
WP5W18E02_02110	COG1979	alcohol dehydrogenase
WP5W18E02_02120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP5W18E02_02130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP5W18E02_02140	COG2964	Protein conserved in bacteria
WP5W18E02_02150	COG3681	Belongs to the UPF0597 family
WP5W18E02_02160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP5W18E02_02170	COG0564	pseudouridine synthase activity
WP5W18E02_02190	COG0542	response to heat
WP5W18E02_02210	COG2502	aspartate--ammonia ligase
WP5W18E02_02220	COG1522	sequence-specific DNA binding
WP5W18E02_02240	COG0516	GMP reductase activity
WP5W18E02_02240	COG0517	IMP dehydrogenase activity
WP5W18E02_02280	COG2205	protein histidine kinase activity
WP5W18E02_02300	COG2204	response regulator
WP5W18E02_02330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP5W18E02_02370	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_02400	COG0243	molybdopterin cofactor binding
WP5W18E02_02410	COG3005	denitrification pathway
WP5W18E02_02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP5W18E02_02430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP5W18E02_02440	COG0569	domain protein
WP5W18E02_02450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP5W18E02_02480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP5W18E02_02500	COG0250	Participates in transcription elongation, termination and antitermination
WP5W18E02_02510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP5W18E02_02520	COG0081	regulation of translation
WP5W18E02_02530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP5W18E02_02540	COG0222	ribosome binding
WP5W18E02_02550	COG0085	RNA polymerase activity
WP5W18E02_02560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP5W18E02_02570	COG2964	Protein conserved in bacteria
WP5W18E02_02580	COG0251	oxidation-reduction process
WP5W18E02_02590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP5W18E02_02610	COG2168	tRNA wobble position uridine thiolation
WP5W18E02_02620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP5W18E02_02630	COG0049	tRNA binding
WP5W18E02_02640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP5W18E02_02650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP5W18E02_02660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP5W18E02_02670	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WP5W18E02_02680	COG2252	PERMEase
WP5W18E02_02690	COG2376	Dihydroxyacetone kinase
WP5W18E02_02700	COG2801	Transposase and inactivated derivatives
WP5W18E02_02720	COG2376	Dihydroxyacetone kinase
WP5W18E02_02730	COG1461	Dihydroxyacetone kinase
WP5W18E02_02770	COG0583	DNA-binding transcription factor activity
WP5W18E02_02780	COG2957	Belongs to the agmatine deiminase family
WP5W18E02_02810	COG2957	Belongs to the agmatine deiminase family
WP5W18E02_02830	COG0628	permease
WP5W18E02_02840	COG0494	nUDIX hydrolase
WP5W18E02_02890	COG0753	catalase activity
WP5W18E02_02900	COG0456	acetyltransferase
WP5W18E02_02960	COG3842	ATPase activity
WP5W18E02_02980	COG1175	transmembrane transport
WP5W18E02_03040	COG0583	DNA-binding transcription factor activity
WP5W18E02_03060	COG1741	Belongs to the pirin family
WP5W18E02_03070	COG2259	Doxx family
WP5W18E02_03080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP5W18E02_03090	COG1074	ATP-dependent DNA helicase activity
WP5W18E02_03100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP5W18E02_03120	COG0004	ammonium transporteR
WP5W18E02_03130	COG0347	Belongs to the P(II) protein family
WP5W18E02_03140	COG3706	GGDEF domain
WP5W18E02_03180	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_03190	COG2205	protein histidine kinase activity
WP5W18E02_03200	COG1278	Cold shock
WP5W18E02_03270	COG2197	response regulator
WP5W18E02_03280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP5W18E02_03290	COG3047	cAMP biosynthetic process
WP5W18E02_03350	COG3135	benzoate transporter
WP5W18E02_03360	COG1396	sequence-specific DNA binding
WP5W18E02_03390	COG2926	Belongs to the UPF0265 family
WP5W18E02_03410	COG3028	Belongs to the UPF0307 family
WP5W18E02_03420	COG0312	modulator of DNA gyrase
WP5W18E02_03440	COG3071	HemY protein
WP5W18E02_03450	COG2959	enzyme of heme biosynthesis
WP5W18E02_03470	COG0181	hydroxymethylbilane synthase activity
WP5W18E02_03480	COG3072	Adenylate cyclase
WP5W18E02_03490	COG0400	carboxylic ester hydrolase activity
WP5W18E02_03500	COG1965	Belongs to the frataxin family
WP5W18E02_03510	COG0019	diaminopimelate decarboxylase activity
WP5W18E02_03520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP5W18E02_03550	COG1011	Hydrolase
WP5W18E02_03570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP5W18E02_03580	COG0561	phosphatase activity
WP5W18E02_03600	COG1988	membrane-bound metal-dependent
WP5W18E02_03610	COG1546	Belongs to the CinA family
WP5W18E02_03610	COG1058	Belongs to the CinA family
WP5W18E02_03630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP5W18E02_03650	COG1522	sequence-specific DNA binding
WP5W18E02_03660	COG1368	sulfuric ester hydrolase activity
WP5W18E02_03690	COG1285	pathogenesis
WP5W18E02_03730	COG4221	oxidoreductase activity
WP5W18E02_03760	COG1979	alcohol dehydrogenase
WP5W18E02_03780	COG2873	o-acetylhomoserine
WP5W18E02_03840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP5W18E02_03860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP5W18E02_03870	COG2949	membrane
WP5W18E02_03880	COG3291	Pkd domain containing protein
WP5W18E02_03890	COG0318	PFAM AMP-dependent synthetase and ligase
WP5W18E02_03900	COG1441	menaquinone biosynthetic process
WP5W18E02_03910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP5W18E02_03920	COG0596	Alpha beta hydrolase
WP5W18E02_03930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP5W18E02_03940	COG1169	isochorismate synthase
WP5W18E02_03950	COG1575	Belongs to the MenA family. Type 1 subfamily
WP5W18E02_03990	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_04000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP5W18E02_04030	COG1671	Belongs to the UPF0178 family
WP5W18E02_04070	COG3263	regulation of cellular component size
WP5W18E02_04080	COG3722	fumarate hydratase activity
WP5W18E02_04090	COG0246	Mannitol dehydrogenase
WP5W18E02_04100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_04100	COG2213	PTS system mannitol-specific
WP5W18E02_04110	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP5W18E02_04130	COG3916	Acyl-homoserine-lactone synthase
WP5W18E02_04140	COG2771	luxR family
WP5W18E02_04170	COG1560	Kdo2-lipid A biosynthetic process
WP5W18E02_04180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP5W18E02_04180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP5W18E02_04190	COG1538	Outer membrane efflux protein
WP5W18E02_04200	COG0494	nUDIX hydrolase
WP5W18E02_04210	COG3151	Protein conserved in bacteria
WP5W18E02_04230	COG3150	esterase
WP5W18E02_04240	COG1051	belongs to the nudix hydrolase family
WP5W18E02_04270	COG1566	PFAM secretion protein HlyD family protein
WP5W18E02_04280	COG1289	transmembrane transporter activity
WP5W18E02_04380	COG0484	heat shock protein binding
WP5W18E02_04400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP5W18E02_04440	COG0204	Acyl-transferase
WP5W18E02_04450	COG1842	Phage shock protein A
WP5W18E02_04480	COG2827	Endonuclease containing a URI domain
WP5W18E02_04490	COG2962	Rard protein
WP5W18E02_04500	COG1573	uracil-dna glycosylase
WP5W18E02_04520	COG0583	DNA-binding transcription factor activity
WP5W18E02_04530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP5W18E02_04540	COG1121	(ABC) transporter
WP5W18E02_04550	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP5W18E02_04590	COG0739	heme binding
WP5W18E02_04610	COG3068	Protein conserved in bacteria
WP5W18E02_04670	COG1522	sequence-specific DNA binding
WP5W18E02_04680	COG0110	maltose O-acetyltransferase activity
WP5W18E02_04690	COG0366	Alpha amylase catalytic
WP5W18E02_04700	COG1263	PTS System
WP5W18E02_04700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_04740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP5W18E02_04750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP5W18E02_04760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP5W18E02_04770	COG2723	6-phospho-beta-galactosidase activity
WP5W18E02_04780	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP5W18E02_04790	COG1940	carbohydrate kinase activity
WP5W18E02_04840	COG1609	Transcriptional regulator
WP5W18E02_04860	COG0252	asparaginase activity
WP5W18E02_04890	COG1803	Methylglyoxal synthase
WP5W18E02_04930	COG1444	tRNA N-acetyltransferase activity
WP5W18E02_04940	COG1565	acr, cog1565
WP5W18E02_04940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP5W18E02_04960	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WP5W18E02_05020	COG0109	protoheme IX farnesyltransferase activity
WP5W18E02_05030	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_05040	COG1177	transmembrane transport
WP5W18E02_05050	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP5W18E02_05060	COG3842	ATPase activity
WP5W18E02_05070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP5W18E02_05080	COG0583	DNA-binding transcription factor activity
WP5W18E02_05090	COG1757	Na H antiporter
WP5W18E02_05120	COG0297	glycogen (starch) synthase activity
WP5W18E02_05130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP5W18E02_05140	COG2813	Specifically methylates the guanine in position
WP5W18E02_05150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP5W18E02_05160	COG5001	Diguanylate cyclase
WP5W18E02_05160	COG4251	negative regulation of phosphorylation
WP5W18E02_05160	COG3706	GGDEF domain
WP5W18E02_05160	COG2203	Gaf domain
WP5W18E02_05170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP5W18E02_05190	COG2995	paraquat-inducible protein a
WP5W18E02_05200	COG3008	intermembrane lipid transfer
WP5W18E02_05200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP5W18E02_05210	COG3009	Protein conserved in bacteria
WP5W18E02_05230	COG3240	lipase activity
WP5W18E02_05260	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP5W18E02_05270	COG1194	a g-specific adenine glycosylase
WP5W18E02_05290	COG3267	Type II secretory pathway component ExeA
WP5W18E02_05290	COG3409	Peptidoglycan-binding domain 1 protein
WP5W18E02_05300	COG0617	tRNA 3'-terminal CCA addition
WP5W18E02_05310	COG0306	phosphate transporter
WP5W18E02_05320	COG1392	Phosphate transport regulator
WP5W18E02_05330	COG3025	triphosphatase activity
WP5W18E02_05340	COG3133	Outer membrane lipoprotein
WP5W18E02_05350	COG0456	acetyltransferase
WP5W18E02_05380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WP5W18E02_05390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP5W18E02_05410	COG3031	protein transport across the cell outer membrane
WP5W18E02_05430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP5W18E02_05440	COG1459	type II secretion system
WP5W18E02_05450	COG2165	general secretion pathway protein
WP5W18E02_05470	COG2165	general secretion pathway protein
WP5W18E02_05480	COG4795	General secretion pathway protein
WP5W18E02_05490	COG3156	type II secretion system protein K
WP5W18E02_05510	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP5W18E02_05540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP5W18E02_05560	COG1902	pentaerythritol trinitrate reductase activity
WP5W18E02_05570	COG1011	Hydrolase
WP5W18E02_05580	COG0494	nUDIX hydrolase
WP5W18E02_05590	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP5W18E02_05600	COG0814	amino acid
WP5W18E02_05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP5W18E02_05640	COG0626	cystathionine gamma-synthase activity
WP5W18E02_05650	COG0460	homoserine dehydrogenase
WP5W18E02_05650	COG0527	aspartate kinase activity
WP5W18E02_05660	COG1346	cytolysis
WP5W18E02_05670	COG1380	Effector of murein hydrolase LrgA
WP5W18E02_05680	COG0583	DNA-binding transcription factor activity
WP5W18E02_05750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP5W18E02_05760	COG5002	protein histidine kinase activity
WP5W18E02_05760	COG5001	Diguanylate cyclase
WP5W18E02_05760	COG3447	MASE1 domain protein
WP5W18E02_05780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP5W18E02_05800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP5W18E02_05810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP5W18E02_05830	COG0137	argininosuccinate synthase activity
WP5W18E02_05840	COG0165	Argininosuccinate lyase
WP5W18E02_05850	COG0583	DNA-binding transcription factor activity
WP5W18E02_05870	COG1942	4-Oxalocrotonate Tautomerase
WP5W18E02_05930	COG0110	maltose O-acetyltransferase activity
WP5W18E02_05940	COG3174	membrane
WP5W18E02_05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_05960	COG1126	abc transporter atp-binding protein
WP5W18E02_05980	COG0765	amino acid transport
WP5W18E02_06010	COG0765	amino acid transport
WP5W18E02_06020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP5W18E02_06030	COG1505	serine-type exopeptidase activity
WP5W18E02_06050	COG1028	Short-chain dehydrogenase reductase Sdr
WP5W18E02_06060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP5W18E02_06090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP5W18E02_06100	COG4991	sh3 domain protein
WP5W18E02_06110	COG2816	NAD+ diphosphatase activity
WP5W18E02_06120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP5W18E02_06130	COG1940	carbohydrate kinase activity
WP5W18E02_06140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP5W18E02_06150	COG0126	phosphoglycerate kinase activity
WP5W18E02_06170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP5W18E02_06230	COG0583	DNA-binding transcription factor activity
WP5W18E02_06250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP5W18E02_06270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP5W18E02_06280	COG1595	DNA-templated transcription, initiation
WP5W18E02_06290	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP5W18E02_06320	COG0481	GTPase activity
WP5W18E02_06330	COG0681	Belongs to the peptidase S26 family
WP5W18E02_06340	COG0571	ribonuclease III activity
WP5W18E02_06360	COG1381	Involved in DNA repair and RecF pathway recombination
WP5W18E02_06370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP5W18E02_06380	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP5W18E02_06390	COG4807	Protein conserved in bacteria
WP5W18E02_06410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP5W18E02_06420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP5W18E02_06430	COG3956	TIGRFAM MazG family protein
WP5W18E02_06440	COG0504	CTP synthase activity
WP5W18E02_06450	COG0148	phosphopyruvate hydratase activity
WP5W18E02_06460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP5W18E02_06470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP5W18E02_06480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WP5W18E02_06490	COG0585	pseudouridine synthase activity
WP5W18E02_06500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP5W18E02_06510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP5W18E02_06520	COG1238	metal cluster binding
WP5W18E02_06530	COG4942	peptidase
WP5W18E02_06530	COG1388	LysM domain
WP5W18E02_06550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP5W18E02_06560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP5W18E02_06570	COG1610	YqeY-like protein
WP5W18E02_06580	COG0358	DNA primase activity
WP5W18E02_06590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP5W18E02_06640	COG0151	Belongs to the GarS family
WP5W18E02_06650	COG0138	bifunctional purine biosynthesis protein purh
WP5W18E02_06680	COG3036	rescue of stalled ribosome
WP5W18E02_06700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP5W18E02_06710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP5W18E02_06730	COG0673	inositol 2-dehydrogenase activity
WP5W18E02_06750	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP5W18E02_06760	COG0330	HflC and HflK could
WP5W18E02_06770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP5W18E02_06770	COG1648	precorrin-2 dehydrogenase activity
WP5W18E02_06780	COG0175	sulfate reduction
WP5W18E02_06790	COG2895	sulfate adenylyltransferase (ATP) activity
WP5W18E02_06800	COG3273	potassium ion transport
WP5W18E02_06800	COG0471	metal ion transport
WP5W18E02_06810	COG0529	Catalyzes the synthesis of activated sulfate
WP5W18E02_06860	COG1136	(ABC) transporter
WP5W18E02_06890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP5W18E02_06920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP5W18E02_06930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP5W18E02_06940	COG0163	prenyltransferase activity
WP5W18E02_06970	COG1131	(ABC) transporter
WP5W18E02_06980	COG0842	Transport permease protein
WP5W18E02_07000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP5W18E02_07010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP5W18E02_07040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP5W18E02_07050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP5W18E02_07060	COG1489	DNA binding
WP5W18E02_07080	COG1643	Atp-dependent helicase
WP5W18E02_07090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP5W18E02_07100	COG0346	lactoylglutathione lyase activity
WP5W18E02_07120	COG2076	Multidrug Resistance protein
WP5W18E02_07150	COG0671	phosphoesterase, PA-phosphatase related
WP5W18E02_07180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP5W18E02_07190	COG0038	chloride channel
WP5W18E02_07210	COG0316	Belongs to the HesB IscA family
WP5W18E02_07230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP5W18E02_07250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP5W18E02_07260	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP5W18E02_07270	COG1178	ABC-type Fe3 transport system permease component
WP5W18E02_07280	COG4143	(ABC) transporter
WP5W18E02_07310	COG0066	3-isopropylmalate dehydratase activity
WP5W18E02_07320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP5W18E02_07330	COG0473	3-isopropylmalate dehydrogenase activity
WP5W18E02_07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP5W18E02_07360	COG0671	phosphoesterase, PA-phosphatase related
WP5W18E02_07390	COG0028	Belongs to the TPP enzyme family
WP5W18E02_07400	COG0440	acetolactate synthase activity
WP5W18E02_07410	COG0280	phosphate acetyltransferase
WP5W18E02_07410	COG0857	belongs to the CobB CobQ family
WP5W18E02_07420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP5W18E02_07440	COG3013	Belongs to the UPF0304 family
WP5W18E02_07450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP5W18E02_07460	COG2716	regulation of RNA biosynthetic process
WP5W18E02_07470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP5W18E02_07480	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP5W18E02_07490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP5W18E02_07520	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP5W18E02_07560	COG0784	Response regulator, receiver
WP5W18E02_07560	COG2198	Histidine kinase
WP5W18E02_07560	COG5002	protein histidine kinase activity
WP5W18E02_07570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WP5W18E02_07590	COG2205	protein histidine kinase activity
WP5W18E02_07590	COG0784	Response regulator, receiver
WP5W18E02_07610	COG0840	transmembrane signaling receptor activity
WP5W18E02_07630	COG1464	Belongs to the NlpA lipoprotein family
WP5W18E02_07640	COG2011	ABC-type metal ion transport system permease component
WP5W18E02_07650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP5W18E02_07690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP5W18E02_07690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP5W18E02_07700	COG0802	atpase or kinase
WP5W18E02_07720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP5W18E02_07730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP5W18E02_07740	COG1923	regulation of RNA biosynthetic process
WP5W18E02_07750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP5W18E02_07760	COG0330	HflC and HflK could
WP5W18E02_07770	COG0330	HflC and HflK could
WP5W18E02_07780	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP5W18E02_07790	COG0142	geranyltranstransferase activity
WP5W18E02_07800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP5W18E02_07810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP5W18E02_07820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP5W18E02_07840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP5W18E02_07850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP5W18E02_07870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP5W18E02_07880	COG2967	ApaG domain
WP5W18E02_07890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP5W18E02_07920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP5W18E02_07930	COG3178	'Phosphotransferase
WP5W18E02_07940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP5W18E02_07950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP5W18E02_07960	COG2252	PERMEase
WP5W18E02_07980	COG0488	(ABC) transporter
WP5W18E02_07990	COG0582	viral genome integration into host DNA
WP5W18E02_08180	COG1846	Transcriptional regulator
WP5W18E02_08260	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
WP5W18E02_08290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP5W18E02_08300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP5W18E02_08350	COG4220	transposase activity
WP5W18E02_08390	COG0740	serine-type endopeptidase activity
WP5W18E02_08560	COG0741	lytic transglycosylase activity
WP5W18E02_08570	COG0463	Glycosyl transferase, family 2
WP5W18E02_08590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WP5W18E02_08640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP5W18E02_08660	COG3721	Heme iron utilization protein
WP5W18E02_08670	COG0748	coenzyme F420 binding
WP5W18E02_08720	COG2814	Major facilitator Superfamily
WP5W18E02_08730	COG2202	Pas domain
WP5W18E02_08730	COG2205	protein histidine kinase activity
WP5W18E02_08750	COG2226	methyltransferase
WP5W18E02_08770	COG1765	OsmC-like protein
WP5W18E02_08800	COG3954	Phosphoribulokinase
WP5W18E02_08810	COG3089	Belongs to the UPF0270 family
WP5W18E02_08820	COG3706	GGDEF domain
WP5W18E02_08820	COG4251	negative regulation of phosphorylation
WP5W18E02_08820	COG5001	Diguanylate cyclase
WP5W18E02_08820	COG2203	Gaf domain
WP5W18E02_08830	COG0429	hydrolase of the alpha beta-hydrolase fold
WP5W18E02_08840	COG0784	Response regulator, receiver
WP5W18E02_08840	COG0835	chemotaxis
WP5W18E02_08860	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP5W18E02_08870	COG1047	Peptidyl-prolyl cis-trans
WP5W18E02_08880	COG2900	Belongs to the SlyX family
WP5W18E02_08900	COG0545	Peptidyl-prolyl cis-trans isomerase
WP5W18E02_08910	COG2204	response regulator
WP5W18E02_08950	COG0737	Belongs to the 5'-nucleotidase family
WP5W18E02_08980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP5W18E02_08990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP5W18E02_08990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP5W18E02_08990	COG0506	proline dehydrogenase activity
WP5W18E02_09010	COG0114	fumarate hydratase activity
WP5W18E02_09030	COG1566	PFAM secretion protein HlyD family protein
WP5W18E02_09120	COG2203	Gaf domain
WP5W18E02_09120	COG2200	EAL domain
WP5W18E02_09120	COG2199	diguanylate cyclase activity
WP5W18E02_09160	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_09170	COG0826	peptidase U32
WP5W18E02_09190	COG3813	Protein conserved in bacteria
WP5W18E02_09230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP5W18E02_09280	COG0300	oxidoreductase activity
WP5W18E02_09320	COG2610	gluconate transmembrane transporter activity
WP5W18E02_09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP5W18E02_09340	COG3622	Belongs to the hyi family
WP5W18E02_09350	COG0235	Class ii aldolase
WP5W18E02_09360	COG3395	kinase activity
WP5W18E02_09370	COG2084	Dehydrogenase
WP5W18E02_09380	COG1349	DNA-binding transcription factor activity
WP5W18E02_09400	COG2133	pyrroloquinoline quinone binding
WP5W18E02_09440	COG2801	Transposase and inactivated derivatives
WP5W18E02_09630	COG4372	Transposase
WP5W18E02_09760	COG2003	Belongs to the UPF0758 family
WP5W18E02_09860	COG5377	YqaJ viral recombinase family
WP5W18E02_09910	COG1605	Chorismate mutase
WP5W18E02_09910	COG0077	Prephenate dehydratase
WP5W18E02_09960	COG3272	Protein of unknown function (DUF1722)
WP5W18E02_09970	COG0789	Transcriptional regulator
WP5W18E02_09980	COG0415	Belongs to the DNA photolyase family
WP5W18E02_10000	COG0300	oxidoreductase activity
WP5W18E02_10030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP5W18E02_10080	COG0783	Belongs to the Dps family
WP5W18E02_10090	COG1151	hydroxylamine reductase activity
WP5W18E02_10110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP5W18E02_10170	COG1203	CRISPR-associated helicase, Cas3
WP5W18E02_10180	COG1518	maintenance of DNA repeat elements
WP5W18E02_10300	COG2003	Belongs to the UPF0758 family
WP5W18E02_10390	COG5377	YqaJ viral recombinase family
WP5W18E02_10420	COG3385	transposase activity
WP5W18E02_10440	COG3311	Transcriptional regulator
WP5W18E02_10460	COG0582	viral genome integration into host DNA
WP5W18E02_10470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_10480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_10490	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_10500	COG5000	phosphorelay sensor kinase activity
WP5W18E02_10500	COG5002	protein histidine kinase activity
WP5W18E02_10510	COG0659	secondary active sulfate transmembrane transporter activity
WP5W18E02_10530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP5W18E02_10540	COG1666	GTP binding
WP5W18E02_10560	COG2211	Major facilitator Superfamily
WP5W18E02_10580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP5W18E02_10600	COG2813	Specifically methylates the guanine in position
WP5W18E02_10610	COG0271	Belongs to the BolA IbaG family
WP5W18E02_10620	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP5W18E02_10630	COG1805	sodium ion transport
WP5W18E02_10640	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP5W18E02_10650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP5W18E02_10660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP5W18E02_10670	COG2871	sodium ion transport
WP5W18E02_10680	COG1477	protein flavinylation
WP5W18E02_10710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP5W18E02_10720	COG0840	transmembrane signaling receptor activity
WP5W18E02_10730	COG0583	DNA-binding transcription factor activity
WP5W18E02_10760	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP5W18E02_10790	COG0473	3-isopropylmalate dehydrogenase activity
WP5W18E02_10800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP5W18E02_10810	COG1611	Belongs to the LOG family
WP5W18E02_10820	COG3706	GGDEF domain
WP5W18E02_10840	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP5W18E02_10840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP5W18E02_10860	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP5W18E02_10910	COG3098	single-species biofilm formation
WP5W18E02_10920	COG0564	pseudouridine synthase activity
WP5W18E02_10940	COG4580	involved in the transport of maltose and maltodextrins
WP5W18E02_10960	COG1263	PTS System
WP5W18E02_10960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_10980	COG2171	N-acyltransferase activity
WP5W18E02_10990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP5W18E02_11000	COG0024	Methionine aminopeptidase
WP5W18E02_11010	COG0052	Belongs to the universal ribosomal protein uS2 family
WP5W18E02_11020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP5W18E02_11030	COG0528	UMP kinase activity
WP5W18E02_11040	COG0233	cytoplasmic translational termination
WP5W18E02_11050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP5W18E02_11060	COG0575	Belongs to the CDS family
WP5W18E02_11070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP5W18E02_11080	COG0750	zinc metalloprotease
WP5W18E02_11110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP5W18E02_11120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP5W18E02_11130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP5W18E02_11140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP5W18E02_11150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP5W18E02_11160	COG0587	DNA-directed DNA polymerase activity
WP5W18E02_11170	COG0825	malonyl-CoA metabolic process
WP5W18E02_11200	COG0814	amino acid
WP5W18E02_11210	COG0531	amino acid
WP5W18E02_11230	COG0488	(ABC) transporter
WP5W18E02_11250	COG3590	peptidase
WP5W18E02_11260	COG0037	tRNA processing
WP5W18E02_11270	COG3706	GGDEF domain
WP5W18E02_11340	COG0366	Alpha amylase catalytic
WP5W18E02_11370	COG0463	Glycosyl transferase, family 2
WP5W18E02_11400	COG2989	Protein conserved in bacteria
WP5W18E02_11410	COG3108	Peptidase M15
WP5W18E02_11430	COG2860	membrane
WP5W18E02_11450	COG1196	nuclear chromosome segregation
WP5W18E02_11460	COG3115	cell septum assembly
WP5W18E02_11470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP5W18E02_11490	COG1328	CTP reductase activity
WP5W18E02_11500	COG0602	queuosine metabolic process
WP5W18E02_11550	COG1566	PFAM secretion protein HlyD family protein
WP5W18E02_11570	COG3290	protein histidine kinase activity
WP5W18E02_11600	COG0667	Aldo Keto reductase
WP5W18E02_11610	COG0697	spore germination
WP5W18E02_11630	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_11640	COG3284	Transcriptional regulator
WP5W18E02_11660	COG3706	GGDEF domain
WP5W18E02_11670	COG0346	lactoylglutathione lyase activity
WP5W18E02_11680	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_11690	COG5002	protein histidine kinase activity
WP5W18E02_11710	COG4783	chaperone-mediated protein folding
WP5W18E02_11740	COG3142	Participates in the control of copper homeostasis
WP5W18E02_11750	COG0545	Peptidyl-prolyl cis-trans isomerase
WP5W18E02_11770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP5W18E02_11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_11800	COG4597	amino acid ABC transporter
WP5W18E02_11810	COG0765	amino acid transport
WP5W18E02_11820	COG1126	abc transporter atp-binding protein
WP5W18E02_11840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP5W18E02_11850	COG0678	peroxiredoxin activity
WP5W18E02_11870	COG0019	diaminopimelate decarboxylase activity
WP5W18E02_11880	COG1115	amino acid carrier protein
WP5W18E02_11890	COG0095	Lipoate-protein ligase
WP5W18E02_11900	COG2233	PERMEase
WP5W18E02_11930	COG0534	Mate efflux family protein
WP5W18E02_11940	COG2207	Transcriptional regulator
WP5W18E02_11950	COG0281	malic enzyme
WP5W18E02_12010	COG0733	neurotransmitter:sodium symporter activity
WP5W18E02_12020	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP5W18E02_12030	COG3706	GGDEF domain
WP5W18E02_12050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_12060	COG1032	radical SAM domain protein
WP5W18E02_12070	COG2801	Transposase and inactivated derivatives
WP5W18E02_12090	COG3039	Transposase
WP5W18E02_12150	COG0673	inositol 2-dehydrogenase activity
WP5W18E02_12160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP5W18E02_12170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP5W18E02_12180	COG1196	nuclear chromosome segregation
WP5W18E02_12180	COG0739	heme binding
WP5W18E02_12180	COG0741	lytic transglycosylase activity
WP5W18E02_12230	COG0788	formyltetrahydrofolate deformylase activity
WP5W18E02_12240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP5W18E02_12260	COG3118	belongs to the thioredoxin family
WP5W18E02_12280	COG0791	NLP P60 protein
WP5W18E02_12290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP5W18E02_12320	COG1388	LysM domain
WP5W18E02_12320	COG1376	ErfK ybiS ycfS ynhG family protein
WP5W18E02_12330	COG2205	protein histidine kinase activity
WP5W18E02_12330	COG0784	Response regulator, receiver
WP5W18E02_12360	COG2205	protein histidine kinase activity
WP5W18E02_12360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_12370	COG2205	protein histidine kinase activity
WP5W18E02_12380	COG3384	dioxygenase
WP5W18E02_12400	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP5W18E02_12420	COG0531	amino acid
WP5W18E02_12440	COG0531	amino acid
WP5W18E02_12470	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_12480	COG1917	Cupin 2, conserved barrel domain protein
WP5W18E02_12480	COG1396	sequence-specific DNA binding
WP5W18E02_12490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP5W18E02_12560	COG4651	solute:proton antiporter activity
WP5W18E02_12560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP5W18E02_12570	COG0405	Gamma-glutamyltransferase
WP5W18E02_12590	COG2974	May be involved in recombination
WP5W18E02_12600	COG1247	-acetyltransferase
WP5W18E02_12610	COG0420	3'-5' exonuclease activity
WP5W18E02_12630	COG3038	cytochrome b561
WP5W18E02_12640	COG2190	(PTS) system
WP5W18E02_12660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_12670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP5W18E02_12680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP5W18E02_12710	COG1720	tRNA m6t6A37 methyltransferase activity
WP5W18E02_12750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP5W18E02_12760	COG4988	ABC transporter
WP5W18E02_12770	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_12800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP5W18E02_12830	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP5W18E02_12840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP5W18E02_12860	COG0083	homoserine kinase activity
WP5W18E02_12870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP5W18E02_12900	COG3039	Transposase
WP5W18E02_12920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP5W18E02_12940	COG3220	belongs to the UPF0276 family
WP5W18E02_13000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP5W18E02_13010	COG1289	transmembrane transporter activity
WP5W18E02_13020	COG1763	Mo-molybdopterin cofactor biosynthetic process
WP5W18E02_13030	COG0746	molybdenum cofactor guanylyltransferase activity
WP5W18E02_13040	COG0281	malic enzyme
WP5W18E02_13100	COG3264	Mechanosensitive ion channel
WP5W18E02_13100	COG1196	nuclear chromosome segregation
WP5W18E02_13120	COG2850	peptidyl-arginine hydroxylation
WP5W18E02_13130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP5W18E02_13140	COG2915	High frequency lysogenization protein hflD homolog
WP5W18E02_13150	COG0482	sulfurtransferase activity
WP5W18E02_13170	COG1187	pseudouridine synthase activity
WP5W18E02_13180	COG0456	acetyltransferase
WP5W18E02_13260	COG0538	isocitrate dehydrogenase activity
WP5W18E02_13280	COG3048	D-serine ammonia-lyase activity
WP5W18E02_13290	COG0583	DNA-binding transcription factor activity
WP5W18E02_13300	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP5W18E02_13310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP5W18E02_13320	COG2375	cellular response to nickel ion
WP5W18E02_13330	COG1538	Outer membrane efflux protein
WP5W18E02_13340	COG0577	efflux transmembrane transporter activity
WP5W18E02_13340	COG1136	(ABC) transporter
WP5W18E02_13350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_13380	COG0497	DNA recombination
WP5W18E02_13390	COG3706	GGDEF domain
WP5W18E02_13400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP5W18E02_13410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP5W18E02_13420	COG0443	Heat shock 70 kDa protein
WP5W18E02_13430	COG0484	heat shock protein binding
WP5W18E02_13490	COG1285	pathogenesis
WP5W18E02_13510	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP5W18E02_13520	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP5W18E02_13540	COG0640	Transcriptional regulator
WP5W18E02_13600	COG0095	Lipoate-protein ligase
WP5W18E02_13630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_13640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_13660	COG0708	Exodeoxyribonuclease III
WP5W18E02_13680	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_13710	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WP5W18E02_13740	COG1846	Transcriptional regulator
WP5W18E02_13780	COG0583	DNA-binding transcription factor activity
WP5W18E02_13790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP5W18E02_13800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP5W18E02_13810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP5W18E02_13820	COG1845	cytochrome c oxidase, subunit III
WP5W18E02_13830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP5W18E02_13840	COG0109	protoheme IX farnesyltransferase activity
WP5W18E02_13850	COG2814	Major facilitator Superfamily
WP5W18E02_13860	COG5507	3-demethylubiquinone-9 3-methyltransferase
WP5W18E02_13870	COG2175	clavaminate synthase activity
WP5W18E02_13880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP5W18E02_13890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WP5W18E02_13900	COG4521	taurine ABC transporter
WP5W18E02_13960	COG3550	peptidyl-serine autophosphorylation
WP5W18E02_13970	COG1396	sequence-specific DNA binding
WP5W18E02_13990	COG0159	tryptophan synthase activity
WP5W18E02_14000	COG0133	tryptophan synthase activity
WP5W18E02_14010	COG0134	indole-3-glycerol-phosphate synthase activity
WP5W18E02_14010	COG0135	phosphoribosylanthranilate isomerase activity
WP5W18E02_14020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP5W18E02_14030	COG0512	Glutamine amidotransferase of anthranilate synthase
WP5W18E02_14030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP5W18E02_14050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP5W18E02_14060	COG0613	PHP domain protein
WP5W18E02_14070	COG0009	L-threonylcarbamoyladenylate synthase
WP5W18E02_14090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP5W18E02_14120	COG1946	Acyl-CoA thioesterase
WP5W18E02_14150	COG1309	transcriptional regulator
WP5W18E02_14160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_14170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_14280	COG4584	PFAM Integrase catalytic
WP5W18E02_14290	COG1484	DNA-dependent DNA replication
WP5W18E02_14340	COG2003	Belongs to the UPF0758 family
WP5W18E02_14370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP5W18E02_14400	COG0583	DNA-binding transcription factor activity
WP5W18E02_14420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP5W18E02_14440	COG1960	acyl-CoA dehydrogenase activity
WP5W18E02_14450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP5W18E02_14470	COG0469	pyruvate kinase activity
WP5W18E02_14480	COG1737	Transcriptional regulator
WP5W18E02_14510	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_14540	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP5W18E02_14660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP5W18E02_14680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP5W18E02_14750	COG0438	transferase activity, transferring glycosyl groups
WP5W18E02_14800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WP5W18E02_14810	COG3206	protein involved in exopolysaccharide biosynthesis
WP5W18E02_14810	COG0489	protein tyrosine kinase activity
WP5W18E02_14860	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP5W18E02_14880	COG3132	Protein of unknown function, DUF480
WP5W18E02_14930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WP5W18E02_14960	COG1278	Cold shock
WP5W18E02_15010	COG4166	transmembrane transport
WP5W18E02_15020	COG0697	spore germination
WP5W18E02_15040	COG0675	Transposase, IS605 OrfB family
WP5W18E02_15050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP5W18E02_15080	COG4166	transmembrane transport
WP5W18E02_15090	COG0622	Phosphoesterase
WP5W18E02_15120	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP5W18E02_15130	COG0835	chemotaxis
WP5W18E02_15130	COG0784	Response regulator, receiver
WP5W18E02_15140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP5W18E02_15150	COG1815	bacterial-type flagellum-dependent cell motility
WP5W18E02_15180	COG1749	Flagellar hook protein flgE
WP5W18E02_15210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP5W18E02_15220	COG1706	bacterial-type flagellum-dependent cell motility
WP5W18E02_15230	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP5W18E02_15230	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP5W18E02_15260	COG2239	Acts as a magnesium transporter
WP5W18E02_15280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP5W18E02_15290	COG2716	regulation of RNA biosynthetic process
WP5W18E02_15320	COG3852	Histidine kinase
WP5W18E02_15340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP5W18E02_15350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP5W18E02_15360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP5W18E02_15370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP5W18E02_15410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP5W18E02_15430	COG0590	tRNA wobble adenosine to inosine editing
WP5W18E02_15440	COG0573	inorganic phosphate transmembrane transporter activity
WP5W18E02_15450	COG0581	inorganic phosphate transmembrane transporter activity
WP5W18E02_15470	COG0704	Plays a role in the regulation of phosphate uptake
WP5W18E02_15480	COG1253	flavin adenine dinucleotide binding
WP5W18E02_15510	COG0531	amino acid
WP5W18E02_15530	COG1126	abc transporter atp-binding protein
WP5W18E02_15540	COG0765	amino acid transport
WP5W18E02_15550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_15560	COG3706	GGDEF domain
WP5W18E02_15570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP5W18E02_15610	COG1785	Belongs to the alkaline phosphatase family
WP5W18E02_15620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP5W18E02_15630	COG0477	Major facilitator Superfamily
WP5W18E02_15640	COG0477	Major facilitator Superfamily
WP5W18E02_15650	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP5W18E02_15670	COG1199	ATP-dependent helicase activity
WP5W18E02_15700	COG1448	Aminotransferase
WP5W18E02_15710	COG0433	COG0433 Predicted ATPase
WP5W18E02_15740	COG0658	competence protein
WP5W18E02_15740	COG2333	competence protein COMEC
WP5W18E02_15750	COG1132	(ABC) transporter
WP5W18E02_15760	COG1663	tetraacyldisaccharide 4'-kinase activity
WP5W18E02_15770	COG2835	tetraacyldisaccharide 4'-kinase activity
WP5W18E02_15780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP5W18E02_15790	COG2197	response regulator
WP5W18E02_15800	COG0322	excinuclease ABC activity
WP5W18E02_15880	COG3039	Transposase
WP5W18E02_15910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP5W18E02_15920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP5W18E02_15930	COG2135	peptidase activity
WP5W18E02_15980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP5W18E02_15990	COG0583	DNA-binding transcription factor activity
WP5W18E02_16020	COG0604	alcohol dehydrogenase
WP5W18E02_16030	COG1309	transcriptional regulator
WP5W18E02_16040	COG2261	transglycosylase associated protein
WP5W18E02_16050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP5W18E02_16070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP5W18E02_16090	COG2801	Transposase and inactivated derivatives
WP5W18E02_16100	COG2203	Gaf domain
WP5W18E02_16100	COG2199	diguanylate cyclase activity
WP5W18E02_16170	COG2119	membrane
WP5W18E02_16180	COG0023	Translation Initiation Factor
WP5W18E02_16200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP5W18E02_16250	COG4139	cobalamin transport
WP5W18E02_16260	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP5W18E02_16270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP5W18E02_16280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP5W18E02_16290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP5W18E02_16300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP5W18E02_16310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP5W18E02_16330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP5W18E02_16340	COG0505	Belongs to the CarA family
WP5W18E02_16350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP5W18E02_16360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP5W18E02_16370	COG3706	GGDEF domain
WP5W18E02_16430	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_16450	COG4104	PAAR repeat-containing protein
WP5W18E02_16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_16530	COG0765	amino acid transport
WP5W18E02_16550	COG0493	'glutamate synthase
WP5W18E02_16560	COG0070	glutamate synthase
WP5W18E02_16560	COG0067	glutamate synthase
WP5W18E02_16560	COG0069	glutamate synthase activity
WP5W18E02_16570	COG1242	4 iron, 4 sulfur cluster binding
WP5W18E02_16690	COG1113	amino acid transport
WP5W18E02_16710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP5W18E02_16720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP5W18E02_16720	COG0574	Belongs to the PEP-utilizing enzyme family
WP5W18E02_16730	COG1119	ATPase activity
WP5W18E02_16770	COG1464	Belongs to the NlpA lipoprotein family
WP5W18E02_16790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP5W18E02_16800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP5W18E02_16820	COG0101	tRNA pseudouridine synthase activity
WP5W18E02_16830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP5W18E02_16840	COG0285	dihydrofolate synthase activity
WP5W18E02_16850	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP5W18E02_16860	COG2920	part of a sulfur-relay system
WP5W18E02_16870	COG1289	transmembrane transporter activity
WP5W18E02_16880	COG0670	Belongs to the BI1 family
WP5W18E02_16960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP5W18E02_16970	COG0840	transmembrane signaling receptor activity
WP5W18E02_16980	COG5001	Diguanylate cyclase
WP5W18E02_16990	COG0564	pseudouridine synthase activity
WP5W18E02_17020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP5W18E02_17040	COG0625	glutathione transferase activity
WP5W18E02_17070	COG0367	asparagine synthase
WP5W18E02_17090	COG0647	UMP catabolic process
WP5W18E02_17100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP5W18E02_17120	COG1902	pentaerythritol trinitrate reductase activity
WP5W18E02_17130	COG1253	flavin adenine dinucleotide binding
WP5W18E02_17160	COG0247	lactate metabolic process
WP5W18E02_17160	COG0277	FAD linked oxidase domain protein
WP5W18E02_17180	COG2050	protein possibly involved in aromatic compounds catabolism
WP5W18E02_17210	COG5001	Diguanylate cyclase
WP5W18E02_17220	COG0583	DNA-binding transcription factor activity
WP5W18E02_17230	COG2814	Major facilitator Superfamily
WP5W18E02_17240	COG2056	Na+-H+ antiporter family
WP5W18E02_17250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP5W18E02_17280	COG0483	inositol monophosphate 1-phosphatase activity
WP5W18E02_17300	COG0625	glutathione transferase activity
WP5W18E02_17310	COG0625	glutathione transferase activity
WP5W18E02_17330	COG0601	transmembrane transport
WP5W18E02_17340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP5W18E02_17350	COG0444	Belongs to the ABC transporter superfamily
WP5W18E02_17360	COG2814	Major facilitator Superfamily
WP5W18E02_17390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP5W18E02_17400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP5W18E02_17410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP5W18E02_17420	COG0509	glycine decarboxylation via glycine cleavage system
WP5W18E02_17430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP5W18E02_17430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP5W18E02_17470	COG0477	Major facilitator Superfamily
WP5W18E02_17480	COG3634	alkyl hydroperoxide reductase activity
WP5W18E02_17490	COG0450	alkyl hydroperoxide reductase
WP5W18E02_17500	COG0517	IMP dehydrogenase activity
WP5W18E02_17510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP5W18E02_17520	COG0343	queuine tRNA-ribosyltransferase activity
WP5W18E02_17530	COG1862	Preprotein translocase
WP5W18E02_17540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP5W18E02_17550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP5W18E02_17560	COG2897	thiosulfate sulfurtransferase activity
WP5W18E02_17580	COG0826	peptidase U32
WP5W18E02_17590	COG0826	peptidase U32
WP5W18E02_17600	COG3154	lipid carrier protein
WP5W18E02_17630	COG1104	cysteine desulfurase activity
WP5W18E02_17640	COG0822	iron-sulfur transferase activity
WP5W18E02_17660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP5W18E02_17670	COG0443	Heat shock 70 kDa protein
WP5W18E02_17680	COG0633	Ferredoxin
WP5W18E02_17700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP5W18E02_17710	COG0105	UTP biosynthetic process
WP5W18E02_17720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP5W18E02_17740	COG1426	Protein conserved in bacteria
WP5W18E02_17760	COG0124	histidyl-tRNA synthetase
WP5W18E02_17770	COG2976	Protein conserved in bacteria
WP5W18E02_17780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP5W18E02_17790	COG1160	GTP binding
WP5W18E02_17800	COG1645	bacterial-type flagellum-dependent swarming motility
WP5W18E02_17820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP5W18E02_17830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP5W18E02_17830	COG0047	phosphoribosylformylglycinamidine synthase activity
WP5W18E02_17840	COG1007	ATP synthesis coupled electron transport
WP5W18E02_17850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP5W18E02_17870	COG0713	ATP synthesis coupled electron transport
WP5W18E02_17880	COG0839	Belongs to the complex I subunit 6 family
WP5W18E02_17890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP5W18E02_17900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP5W18E02_17910	COG1034	ATP synthesis coupled electron transport
WP5W18E02_17940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP5W18E02_17940	COG0649	NAD binding
WP5W18E02_17950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP5W18E02_17960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP5W18E02_17970	COG1360	Flagellar Motor Protein
WP5W18E02_17980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP5W18E02_18060	COG4974	Belongs to the 'phage' integrase family
WP5W18E02_18090	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP5W18E02_18130	COG0724	RNA recognition motif
WP5W18E02_18140	COG4989	oxidoreductase activity
WP5W18E02_18190	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_18200	COG0583	DNA-binding transcription factor activity
WP5W18E02_18220	COG3300	MHYT domain
WP5W18E02_18220	COG5001	Diguanylate cyclase
WP5W18E02_18230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP5W18E02_18290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP5W18E02_18300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP5W18E02_18310	COG0539	negative regulation of cytoplasmic translation
WP5W18E02_18320	COG0776	regulation of translation
WP5W18E02_18340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP5W18E02_18380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP5W18E02_18390	COG0602	queuosine metabolic process
WP5W18E02_18400	COG3530	Putative quorum-sensing-regulated virulence factor
WP5W18E02_18410	COG2096	Adenosyltransferase
WP5W18E02_18420	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP5W18E02_18430	COG1757	Na H antiporter
WP5W18E02_18440	COG1435	thymidine kinase activity
WP5W18E02_18490	COG0561	phosphatase activity
WP5W18E02_18500	COG1349	DNA-binding transcription factor activity
WP5W18E02_18510	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP5W18E02_18520	COG3385	transposase activity
WP5W18E02_18600	COG4584	PFAM Integrase catalytic
WP5W18E02_18610	COG1484	DNA-dependent DNA replication
WP5W18E02_18760	COG5642	Protein of unknown function (DUF2384)
WP5W18E02_18810	COG2801	Transposase and inactivated derivatives
WP5W18E02_18850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP5W18E02_18860	COG0626	cystathionine gamma-synthase activity
WP5W18E02_18880	COG2910	NAD(P)H-binding
WP5W18E02_18890	COG0583	DNA-binding transcription factor activity
WP5W18E02_18900	COG1917	Cupin 2, conserved barrel domain protein
WP5W18E02_18900	COG4977	sequence-specific DNA binding
WP5W18E02_18910	COG2200	EAL domain
WP5W18E02_18920	COG3706	GGDEF domain
WP5W18E02_18970	COG4774	siderophore transport
WP5W18E02_18990	COG0583	DNA-binding transcription factor activity
WP5W18E02_19000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP5W18E02_19020	COG0517	IMP dehydrogenase activity
WP5W18E02_19020	COG0516	GMP reductase activity
WP5W18E02_19030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP5W18E02_19040	COG3046	protein related to deoxyribodipyrimidine photolyase
WP5W18E02_19060	COG3088	subunit of a heme lyase
WP5W18E02_19060	COG4235	cytochrome complex assembly
WP5W18E02_19070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP5W18E02_19080	COG1138	Cytochrome C-type biogenesis protein
WP5W18E02_19090	COG3301	Polysulphide reductase, NrfD
WP5W18E02_19100	COG0437	4 iron, 4 sulfur cluster binding
WP5W18E02_19110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP5W18E02_19130	COG0247	lactate metabolic process
WP5W18E02_19140	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP5W18E02_19150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP5W18E02_19160	COG3012	SEC-C Motif Domain Protein
WP5W18E02_19170	COG0840	transmembrane signaling receptor activity
WP5W18E02_19180	COG1846	Transcriptional regulator
WP5W18E02_19180	COG1940	carbohydrate kinase activity
WP5W18E02_19190	COG3290	protein histidine kinase activity
WP5W18E02_19200	COG4565	transcriptional regulatory protein
WP5W18E02_19230	COG3181	Tripartite tricarboxylate transporter family receptor
WP5W18E02_19240	COG0739	heme binding
WP5W18E02_19240	COG0741	lytic transglycosylase activity
WP5W18E02_19240	COG1196	nuclear chromosome segregation
WP5W18E02_19250	COG0569	domain protein
WP5W18E02_19250	COG2985	domain, Protein
WP5W18E02_19270	COG0556	nucleotide-excision repair
WP5W18E02_19290	COG0586	Pfam SNARE associated Golgi protein
WP5W18E02_19300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP5W18E02_19310	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP5W18E02_19320	COG2186	Transcriptional regulator
WP5W18E02_19330	COG2719	SpoVR family
WP5W18E02_19340	COG2718	Belongs to the UPF0229 family
WP5W18E02_19350	COG2766	serine protein kinase
WP5W18E02_19360	COG0514	ATP-dependent DNA helicase (RecQ)
WP5W18E02_19370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP5W18E02_19380	COG0814	amino acid
WP5W18E02_19450	COG0058	SHG alpha-glucan phosphorylase activity
WP5W18E02_19470	COG0471	metal ion transport
WP5W18E02_19480	COG3118	belongs to the thioredoxin family
WP5W18E02_19500	COG1132	(ABC) transporter
WP5W18E02_19510	COG1132	(ABC) transporter
WP5W18E02_19540	COG2501	S4 domain
WP5W18E02_19560	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP5W18E02_19610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP5W18E02_19620	COG2329	Antibiotic biosynthesis monooxygenase
WP5W18E02_19670	COG1742	UPF0060 membrane protein
WP5W18E02_19700	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_19710	COG0386	Belongs to the glutathione peroxidase family
WP5W18E02_19730	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP5W18E02_19750	COG0730	response to heat
WP5W18E02_19760	COG0583	DNA-binding transcription factor activity
WP5W18E02_19790	COG3593	DNA synthesis involved in DNA repair
WP5W18E02_19810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP5W18E02_19820	COG1011	Hydrolase
WP5W18E02_19830	COG1473	amidohydrolase
WP5W18E02_19860	COG0205	6-phosphofructokinase activity
WP5W18E02_19880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP5W18E02_19890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP5W18E02_19910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP5W18E02_19920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP5W18E02_19970	COG0588	phosphoglycerate mutase activity
WP5W18E02_19990	COG0675	Transposase, IS605 OrfB family
WP5W18E02_20030	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_20060	COG2824	Alkylphosphonate utilization operon protein PhnA
WP5W18E02_20140	COG2840	Smr protein MutS2
WP5W18E02_20150	COG2890	protein-(glutamine-N5) methyltransferase activity
WP5W18E02_20160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP5W18E02_20180	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_20190	COG5654	RES domain protein
WP5W18E02_20210	COG0814	amino acid
WP5W18E02_20220	COG1609	Transcriptional regulator
WP5W18E02_20230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_20230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_20240	COG1105	Belongs to the carbohydrate kinase PfkB family
WP5W18E02_20250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP5W18E02_20250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP5W18E02_20250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP5W18E02_20260	COG3313	Fe-S protein
WP5W18E02_20270	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP5W18E02_20280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP5W18E02_20290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP5W18E02_20300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP5W18E02_20320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP5W18E02_20370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP5W18E02_20380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP5W18E02_20390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP5W18E02_20400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP5W18E02_20420	COG4974	Belongs to the 'phage' integrase family
WP5W18E02_20430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP5W18E02_20440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP5W18E02_20440	COG0072	phenylalanine-tRNA ligase activity
WP5W18E02_20450	COG0776	regulation of translation
WP5W18E02_20520	COG0675	Transposase, IS605 OrfB family
WP5W18E02_20540	COG1609	Transcriptional regulator
WP5W18E02_20550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP5W18E02_20560	COG1879	ABC-type sugar transport system periplasmic component
WP5W18E02_20570	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP5W18E02_20580	COG1129	ABC transporter
WP5W18E02_20590	COG1869	D-ribose catabolic process
WP5W18E02_20600	COG0625	glutathione transferase activity
WP5W18E02_20630	COG0037	tRNA processing
WP5W18E02_20640	COG0589	response to stress
WP5W18E02_20650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP5W18E02_20680	COG2217	Heavy metal translocating P-type atpase
WP5W18E02_20700	COG2010	Cytochrome c
WP5W18E02_20730	COG3278	Belongs to the heme-copper respiratory oxidase family
WP5W18E02_20750	COG1956	GAF domain-containing protein
WP5W18E02_20760	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP5W18E02_20780	COG0308	aminopeptidase N
WP5W18E02_20800	COG2902	Dehydrogenase
WP5W18E02_20810	COG0167	dihydroorotate dehydrogenase activity
WP5W18E02_20830	COG0116	Belongs to the methyltransferase superfamily
WP5W18E02_20830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP5W18E02_20870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP5W18E02_20880	COG1067	ATP-dependent peptidase activity
WP5W18E02_20900	COG3141	response to X-ray
WP5W18E02_20930	COG2995	paraquat-inducible protein a
WP5W18E02_20940	COG3008	intermembrane lipid transfer
WP5W18E02_20950	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP5W18E02_20950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP5W18E02_20980	COG0084	hydrolase, TatD family'
WP5W18E02_20990	COG0470	DNA polymerase III
WP5W18E02_21000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP5W18E02_21010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP5W18E02_21020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP5W18E02_21030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP5W18E02_21040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP5W18E02_21050	COG1028	Short-chain dehydrogenase reductase Sdr
WP5W18E02_21070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP5W18E02_21080	COG0416	fatty acid biosynthetic process
WP5W18E02_21090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP5W18E02_21130	COG0564	pseudouridine synthase activity
WP5W18E02_21140	COG1530	ribonuclease E activity
WP5W18E02_21150	COG0306	phosphate transporter
WP5W18E02_21160	COG0717	Belongs to the dCTP deaminase family
WP5W18E02_21170	COG0572	uridine kinase
WP5W18E02_21180	COG0489	protein tyrosine kinase activity
WP5W18E02_21190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP5W18E02_21190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP5W18E02_21210	COG1254	Belongs to the acylphosphatase family
WP5W18E02_21220	COG0840	transmembrane signaling receptor activity
WP5W18E02_21230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP5W18E02_21260	COG0709	Synthesizes selenophosphate from selenide and ATP
WP5W18E02_21270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP5W18E02_21280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP5W18E02_21310	COG3437	response regulator, receiver
WP5W18E02_21310	COG3850	Histidine kinase
WP5W18E02_21310	COG4999	Histidine kinase
WP5W18E02_21310	COG2205	protein histidine kinase activity
WP5W18E02_21320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP5W18E02_21340	COG1643	Atp-dependent helicase
WP5W18E02_21350	COG0617	tRNA 3'-terminal CCA addition
WP5W18E02_21350	COG0517	IMP dehydrogenase activity
WP5W18E02_21350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP5W18E02_21360	COG2197	response regulator
WP5W18E02_21390	COG0583	DNA-binding transcription factor activity
WP5W18E02_21400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP5W18E02_21420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP5W18E02_21430	COG2832	Protein of unknown function (DUF454)
WP5W18E02_21440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP5W18E02_21460	COG0697	spore germination
WP5W18E02_21490	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WP5W18E02_21500	COG0318	PFAM AMP-dependent synthetase and ligase
WP5W18E02_21510	COG0596	Alpha beta hydrolase
WP5W18E02_21530	COG1214	PFAM Peptidase M22, glycoprotease
WP5W18E02_21540	COG1199	ATP-dependent helicase activity
WP5W18E02_21560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP5W18E02_21570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP5W18E02_21580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP5W18E02_21590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP5W18E02_21590	COG0131	Imidazoleglycerol-phosphate dehydratase
WP5W18E02_21600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP5W18E02_21610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP5W18E02_21620	COG3437	response regulator, receiver
WP5W18E02_21640	COG2198	Histidine kinase
WP5W18E02_21640	COG2205	protein histidine kinase activity
WP5W18E02_21640	COG0784	Response regulator, receiver
WP5W18E02_21650	COG0107	imidazoleglycerol-phosphate synthase activity
WP5W18E02_21660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP5W18E02_21660	COG0140	phosphoribosyl-ATP diphosphatase activity
WP5W18E02_21680	COG2378	regulation of single-species biofilm formation
WP5W18E02_21690	COG0318	PFAM AMP-dependent synthetase and ligase
WP5W18E02_21700	COG0675	Transposase, IS605 OrfB family
WP5W18E02_21720	COG3134	Outer membrane lipoprotein
WP5W18E02_21750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP5W18E02_21790	COG4681	YaeQ
WP5W18E02_21810	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP5W18E02_21810	COG1024	Enoyl-CoA hydratase
WP5W18E02_21820	COG0183	Belongs to the thiolase family
WP5W18E02_21830	COG0714	Associated with various cellular activities
WP5W18E02_21870	COG2304	oxidoreductase activity
WP5W18E02_21890	COG1595	DNA-templated transcription, initiation
WP5W18E02_21910	COG2067	long-chain fatty acid transport protein
WP5W18E02_21920	COG2067	long-chain fatty acid transport protein
WP5W18E02_21930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP5W18E02_21960	COG1301	dicarboxylic acid transport
WP5W18E02_21970	COG3123	guanosine phosphorylase activity
WP5W18E02_21980	COG1760	l-serine dehydratase
WP5W18E02_21990	COG1760	l-serine dehydratase
WP5W18E02_22000	COG2951	lytic endotransglycosylase activity
WP5W18E02_22010	COG3100	YcgL domain-containing protein
WP5W18E02_22020	COG0850	regulation of cytokinetic process
WP5W18E02_22030	COG2894	cell division
WP5W18E02_22040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP5W18E02_22050	COG3099	Belongs to the UPF0263 family
WP5W18E02_22060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP5W18E02_22090	COG2996	Protein conserved in bacteria
WP5W18E02_22150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP5W18E02_22160	COG0697	spore germination
WP5W18E02_22170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP5W18E02_22180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP5W18E02_22210	COG0307	riboflavin synthase, alpha
WP5W18E02_22230	COG0534	Mate efflux family protein
WP5W18E02_22240	COG0417	DNA replication proofreading
WP5W18E02_22270	COG1560	Kdo2-lipid A biosynthetic process
WP5W18E02_22280	COG1560	Kdo2-lipid A biosynthetic process
WP5W18E02_22300	COG0583	DNA-binding transcription factor activity
WP5W18E02_22310	COG0673	inositol 2-dehydrogenase activity
WP5W18E02_22320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP5W18E02_22360	COG0583	DNA-binding transcription factor activity
WP5W18E02_22380	COG2723	6-phospho-beta-galactosidase activity
WP5W18E02_22390	COG0583	DNA-binding transcription factor activity
WP5W18E02_22410	COG0243	molybdopterin cofactor binding
WP5W18E02_22420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP5W18E02_22450	COG0583	DNA-binding transcription factor activity
WP5W18E02_22460	COG1879	ABC-type sugar transport system periplasmic component
WP5W18E02_22470	COG1129	ABC transporter
WP5W18E02_22480	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP5W18E02_22490	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP5W18E02_22510	COG0730	response to heat
WP5W18E02_22530	COG1028	Short-chain dehydrogenase reductase Sdr
WP5W18E02_22550	COG1024	Enoyl-CoA hydratase
WP5W18E02_22560	COG1024	Enoyl-CoA hydratase
WP5W18E02_22570	COG1960	acyl-CoA dehydrogenase activity
WP5W18E02_22590	COG1960	acyl-CoA dehydrogenase activity
WP5W18E02_22600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP5W18E02_22610	COG1024	Enoyl-CoA hydratase
WP5W18E02_22670	COG1584	GPR1 FUN34 yaaH family protein
WP5W18E02_22680	COG3228	Belongs to the MtfA family
WP5W18E02_22700	COG1115	amino acid carrier protein
WP5W18E02_22710	COG1024	Enoyl-CoA hydratase
WP5W18E02_22740	COG3162	membrane
WP5W18E02_22750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP5W18E02_22760	COG0488	(ABC) transporter
WP5W18E02_22770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP5W18E02_22780	COG0776	regulation of translation
WP5W18E02_22790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP5W18E02_22800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP5W18E02_22810	COG0740	serine-type endopeptidase activity
WP5W18E02_22820	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP5W18E02_22840	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP5W18E02_22850	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP5W18E02_22860	COG1136	(ABC) transporter
WP5W18E02_22870	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP5W18E02_22890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP5W18E02_22900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP5W18E02_22920	COG0697	spore germination
WP5W18E02_22940	COG2062	phosphohistidine phosphatase, SixA
WP5W18E02_22980	COG1846	Transcriptional regulator
WP5W18E02_23030	COG3039	Transposase
WP5W18E02_23050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP5W18E02_23050	COG0519	Catalyzes the synthesis of GMP from XMP
WP5W18E02_23060	COG0516	GMP reductase activity
WP5W18E02_23060	COG0517	IMP dehydrogenase activity
WP5W18E02_23080	COG0366	Alpha amylase catalytic
WP5W18E02_23080	COG1874	Beta-galactosidase
WP5W18E02_23100	COG1570	exodeoxyribonuclease VII activity
WP5W18E02_23120	COG2885	chlorophyll binding
WP5W18E02_23130	COG2199	diguanylate cyclase activity
WP5W18E02_23160	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP5W18E02_23180	COG3768	UPF0283 membrane protein
WP5W18E02_23190	COG3106	COG3106 Predicted ATPase
WP5W18E02_23230	COG1842	Phage shock protein A
WP5W18E02_23240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP5W18E02_23280	COG4171	peptide transport system, permease
WP5W18E02_23310	COG4172	Belongs to the ABC transporter superfamily
WP5W18E02_23330	COG1609	Transcriptional regulator
WP5W18E02_23340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_23340	COG1263	PTS System
WP5W18E02_23350	COG2723	6-phospho-beta-galactosidase activity
WP5W18E02_23360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP5W18E02_23370	COG1286	toxin biosynthetic process
WP5W18E02_23380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP5W18E02_23390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP5W18E02_23400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP5W18E02_23410	COG1674	ftsk spoiiie
WP5W18E02_23410	COG0531	amino acid
WP5W18E02_23430	COG0686	Belongs to the AlaDH PNT family
WP5W18E02_23440	COG0492	ferredoxin-NADP+ reductase activity
WP5W18E02_23450	COG3706	GGDEF domain
WP5W18E02_23460	COG3134	Outer membrane lipoprotein
WP5W18E02_23470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP5W18E02_23480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP5W18E02_23490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP5W18E02_23500	COG0542	response to heat
WP5W18E02_23510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP5W18E02_23520	COG1278	Cold shock
WP5W18E02_23530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP5W18E02_23570	COG1944	ATP diphosphatase activity
WP5W18E02_23580	COG2116	formate transmembrane transporter activity
WP5W18E02_23590	COG1882	Formate acetyltransferase
WP5W18E02_23600	COG2983	Belongs to the UPF0260 family
WP5W18E02_23610	COG2801	Transposase and inactivated derivatives
WP5W18E02_23640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WP5W18E02_23650	COG0045	succinate-CoA ligase (ADP-forming) activity
WP5W18E02_23660	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP5W18E02_23670	COG0567	Dehydrogenase, E1 component
WP5W18E02_23700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP5W18E02_23710	COG2009	succinate dehydrogenase
WP5W18E02_23750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP5W18E02_23760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP5W18E02_23760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP5W18E02_23780	COG3069	C4-dicarboxylate transmembrane transporter activity
WP5W18E02_23810	COG1451	nucleotide metabolic process
WP5W18E02_23840	COG0254	rRNA binding
WP5W18E02_23850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP5W18E02_23870	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP5W18E02_23880	COG1129	ABC transporter
WP5W18E02_23890	COG1879	ABC-type sugar transport system periplasmic component
WP5W18E02_23900	COG1069	ribulokinase activity
WP5W18E02_23920	COG2160	L-arabinose isomerase activity
WP5W18E02_23940	COG0436	Aminotransferase
WP5W18E02_23950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP5W18E02_23980	COG0392	lysyltransferase activity
WP5W18E02_23980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP5W18E02_23990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP5W18E02_24010	COG0469	pyruvate kinase activity
WP5W18E02_24030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_24030	COG1263	PTS System
WP5W18E02_24040	COG1874	Beta-galactosidase
WP5W18E02_24050	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WP5W18E02_24060	COG3833	ABC-type maltose transport systems, permease component
WP5W18E02_24070	COG1175	transmembrane transport
WP5W18E02_24080	COG2182	Extracellular solute-binding protein
WP5W18E02_24190	COG4580	involved in the transport of maltose and maltodextrins
WP5W18E02_24200	COG1609	Transcriptional regulator
WP5W18E02_24210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP5W18E02_24220	COG1085	galactose-1-phosphate uridylyltransferase
WP5W18E02_24230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP5W18E02_24240	COG2801	Transposase and inactivated derivatives
WP5W18E02_24250	COG0582	viral genome integration into host DNA
WP5W18E02_24260	COG2925	Exonuclease
WP5W18E02_24280	COG3345	alpha-galactosidase
WP5W18E02_24290	COG1380	Effector of murein hydrolase LrgA
WP5W18E02_24300	COG1346	cytolysis
WP5W18E02_24310	COG0295	cytidine deaminase activity
WP5W18E02_24320	COG1022	Amp-dependent synthetase and ligase
WP5W18E02_24350	COG0861	Integral membrane protein TerC family
WP5W18E02_24370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP5W18E02_24380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP5W18E02_24390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP5W18E02_24470	COG4771	TonB-dependent receptor
WP5W18E02_24480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP5W18E02_24490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP5W18E02_24500	COG1120	ATPase activity
WP5W18E02_24530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP5W18E02_24550	COG1028	Short-chain dehydrogenase reductase Sdr
WP5W18E02_24560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP5W18E02_24570	COG1535	isochorismatase
WP5W18E02_24570	COG3433	isochorismatase activity
WP5W18E02_24580	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP5W18E02_24630	COG3300	MHYT domain
WP5W18E02_24630	COG5001	Diguanylate cyclase
WP5W18E02_24660	COG0840	transmembrane signaling receptor activity
WP5W18E02_24670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP5W18E02_24680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP5W18E02_24690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP5W18E02_24700	COG0563	adenylate kinase activity
WP5W18E02_24710	COG0326	Molecular chaperone. Has ATPase activity
WP5W18E02_24720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP5W18E02_24740	COG3158	transport of potassium into the cell
WP5W18E02_24750	COG3158	transport of potassium into the cell
WP5W18E02_24760	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP5W18E02_24770	COG0298	carbon dioxide binding
WP5W18E02_24790	COG0309	Hydrogenase expression formation protein (HypE)
WP5W18E02_24800	COG0375	protein maturation
WP5W18E02_24820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP5W18E02_24830	COG3842	ATPase activity
WP5W18E02_24840	COG0444	Belongs to the ABC transporter superfamily
WP5W18E02_24850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP5W18E02_24880	COG1773	rubredoxin
WP5W18E02_24890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP5W18E02_24900	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP5W18E02_24910	COG5557	Pfam Polysulphide reductase, NrfD
WP5W18E02_24920	COG0437	4 iron, 4 sulfur cluster binding
WP5W18E02_24930	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP5W18E02_24940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP5W18E02_24960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP5W18E02_24980	COG3039	Transposase
WP5W18E02_25000	COG2199	diguanylate cyclase activity
WP5W18E02_25000	COG2203	Gaf domain
WP5W18E02_25120	COG1484	DNA-dependent DNA replication
WP5W18E02_25130	COG4584	PFAM Integrase catalytic
WP5W18E02_25140	COG3039	Transposase
WP5W18E02_25180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP5W18E02_25270	COG0659	secondary active sulfate transmembrane transporter activity
WP5W18E02_25290	COG0300	oxidoreductase activity
WP5W18E02_25300	COG2308	Evidence 4 Homologs of previously reported genes of
WP5W18E02_25370	COG0672	)-iron permease
WP5W18E02_25420	COG2814	Major facilitator Superfamily
WP5W18E02_25460	COG1136	(ABC) transporter
WP5W18E02_25530	COG1139	Iron-sulfur cluster binding protein
WP5W18E02_25540	COG0247	lactate metabolic process
WP5W18E02_25550	COG1620	l-lactate permease
WP5W18E02_25560	COG0583	DNA-binding transcription factor activity
WP5W18E02_25610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP5W18E02_25620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP5W18E02_25620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP5W18E02_25630	COG0527	aspartate kinase activity
WP5W18E02_25650	COG1368	sulfuric ester hydrolase activity
WP5W18E02_25660	COG0393	Putative heavy-metal-binding
WP5W18E02_25670	COG1252	NADH dehydrogenase
WP5W18E02_25680	COG3150	esterase
WP5W18E02_25690	COG1164	Oligoendopeptidase f
WP5W18E02_25700	COG1164	Oligoendopeptidase f
WP5W18E02_25710	COG2354	Protein conserved in bacteria
WP5W18E02_25740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP5W18E02_25760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP5W18E02_25830	COG0537	adenosine 5'-monophosphoramidase activity
WP5W18E02_25860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP5W18E02_25880	COG1301	dicarboxylic acid transport
WP5W18E02_25900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP5W18E02_25910	COG0861	Integral membrane protein TerC family
WP5W18E02_25930	COG0444	Belongs to the ABC transporter superfamily
WP5W18E02_25940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP5W18E02_25950	COG0601	transmembrane transport
WP5W18E02_25970	COG2095	MarC family integral membrane protein
WP5W18E02_25980	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_25980	COG1454	alcohol dehydrogenase
WP5W18E02_26000	COG3275	phosphorelay sensor kinase activity
WP5W18E02_26010	COG3279	Response regulator of the LytR AlgR family
WP5W18E02_26020	COG1966	Carbon starvation protein
WP5W18E02_26030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP5W18E02_26030	COG3264	Mechanosensitive ion channel
WP5W18E02_26050	COG1566	PFAM secretion protein HlyD family protein
WP5W18E02_26060	COG1061	Type III restriction enzyme res subunit
WP5W18E02_26070	COG2027	D-alanyl-D-alanine carboxypeptidase
WP5W18E02_26080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP5W18E02_26100	COG0436	Aminotransferase
WP5W18E02_26110	COG1288	antiporter activity
WP5W18E02_26120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP5W18E02_26210	COG2801	Transposase and inactivated derivatives
WP5W18E02_26240	COG0640	Transcriptional regulator
WP5W18E02_26430	COG2932	Transcriptional regulator
WP5W18E02_26470	COG0697	spore germination
WP5W18E02_26490	COG0675	Transposase, IS605 OrfB family
WP5W18E02_26500	COG4657	Part of a membrane complex involved in electron transport
WP5W18E02_26510	COG2878	Part of a membrane complex involved in electron transport
WP5W18E02_26530	COG4658	electron transport chain
WP5W18E02_26540	COG4659	FMN binding
WP5W18E02_26550	COG4660	Part of a membrane complex involved in electron transport
WP5W18E02_26560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP5W18E02_26570	COG0346	lactoylglutathione lyase activity
WP5W18E02_26610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP5W18E02_26630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP5W18E02_26640	COG1086	Polysaccharide biosynthesis protein
WP5W18E02_26650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP5W18E02_26670	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP5W18E02_26680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP5W18E02_26700	COG2089	acid synthase
WP5W18E02_26750	COG2826	transposase and inactivated derivatives, IS30 family
WP5W18E02_26800	COG2226	methyltransferase
WP5W18E02_26900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP5W18E02_26900	COG0301	tRNA thio-modification
WP5W18E02_27250	COG3645	SOS response
WP5W18E02_27250	COG3646	Phage regulatory protein
WP5W18E02_27340	COG3645	SOS response
WP5W18E02_27340	COG3646	Phage regulatory protein
WP5W18E02_27360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP5W18E02_27430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP5W18E02_27500	COG1674	ftsk spoiiie
WP5W18E02_27590	COG0582	viral genome integration into host DNA
WP5W18E02_27610	COG4953	penicillin-binding protein 1C
WP5W18E02_27620	COG2373	Large extracellular alpha-helical protein
WP5W18E02_27630	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP5W18E02_27650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP5W18E02_27670	COG4160	amino acid transport
WP5W18E02_27690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_27710	COG2431	L-lysine efflux transmembrane transporter activity
WP5W18E02_27720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP5W18E02_27730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_27780	COG1393	Belongs to the ArsC family
WP5W18E02_27800	COG4783	chaperone-mediated protein folding
WP5W18E02_27810	COG0425	Belongs to the sulfur carrier protein TusA family
WP5W18E02_27840	COG0596	Alpha beta hydrolase
WP5W18E02_27860	COG3842	ATPase activity
WP5W18E02_27870	COG3833	ABC-type maltose transport systems, permease component
WP5W18E02_27880	COG1175	transmembrane transport
WP5W18E02_27900	COG3081	Nucleoid-associated protein
WP5W18E02_27910	COG3082	Protein of unknown function (DUF1414)
WP5W18E02_27920	COG3083	sulfuric ester hydrolase activity
WP5W18E02_27930	COG4771	TonB-dependent receptor
WP5W18E02_27940	COG1770	oligopeptidase
WP5W18E02_27980	COG4574	serine-type endopeptidase inhibitor activity
WP5W18E02_27990	COG3085	chromosome segregation
WP5W18E02_28010	COG0287	Prephenate dehydrogenase
WP5W18E02_28010	COG1605	Chorismate mutase
WP5W18E02_28020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP5W18E02_28030	COG0584	glycerophosphoryl diester phosphodiesterase
WP5W18E02_28050	COG1349	DNA-binding transcription factor activity
WP5W18E02_28060	COG2271	Major facilitator Superfamily
WP5W18E02_28070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP5W18E02_28080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP5W18E02_28090	COG0583	DNA-binding transcription factor activity
WP5W18E02_28130	COG0656	L-ascorbic acid biosynthetic process
WP5W18E02_28140	COG2814	Major facilitator Superfamily
WP5W18E02_28160	COG1294	oxidase, subunit
WP5W18E02_28180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP5W18E02_28200	COG2979	Protein of unknown function (DUF533)
WP5W18E02_28240	COG0583	DNA-binding transcription factor activity
WP5W18E02_28260	COG2807	transmembrane transport
WP5W18E02_28270	COG1187	pseudouridine synthase activity
WP5W18E02_28280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP5W18E02_28340	COG1061	Type III restriction enzyme res subunit
WP5W18E02_28400	COG1166	arginine decarboxylase activity
WP5W18E02_28410	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP5W18E02_28440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP5W18E02_28470	COG0583	DNA-binding transcription factor activity
WP5W18E02_28490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP5W18E02_28500	COG0840	transmembrane signaling receptor activity
WP5W18E02_28510	COG0840	transmembrane signaling receptor activity
WP5W18E02_28520	COG0302	gtp cyclohydrolase
WP5W18E02_28540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP5W18E02_28570	COG2267	carboxylic ester hydrolase activity
WP5W18E02_28580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP5W18E02_28610	COG0314	molybdopterin synthase activity
WP5W18E02_28620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP5W18E02_28630	COG0315	cyclic pyranopterin monophosphate synthase activity
WP5W18E02_28640	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP5W18E02_28650	COG3005	denitrification pathway
WP5W18E02_28670	COG0348	domain, Protein
WP5W18E02_28680	COG0437	4 iron, 4 sulfur cluster binding
WP5W18E02_28690	COG0243	molybdopterin cofactor binding
WP5W18E02_28710	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP5W18E02_28710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP5W18E02_28720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP5W18E02_28730	COG3850	Histidine kinase
WP5W18E02_28740	COG2197	response regulator
WP5W18E02_28790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WP5W18E02_28810	COG0121	glutamine amidotransferase
WP5W18E02_28820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP5W18E02_28830	COG1960	acyl-CoA dehydrogenase activity
WP5W18E02_28840	COG0784	Response regulator, receiver
WP5W18E02_28840	COG3437	response regulator, receiver
WP5W18E02_28860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP5W18E02_28870	COG0328	RNA-DNA hybrid ribonuclease activity
WP5W18E02_28880	COG2226	methyltransferase
WP5W18E02_28890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP5W18E02_28900	COG1388	LysM domain
WP5W18E02_28900	COG0741	lytic transglycosylase activity
WP5W18E02_28930	COG1607	acyl-coa hydrolase
WP5W18E02_28960	COG0741	lytic transglycosylase activity
WP5W18E02_28980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP5W18E02_29000	COG2911	Protein conserved in bacteria
WP5W18E02_29010	COG0729	surface antigen
WP5W18E02_29030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP5W18E02_29050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP5W18E02_29060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP5W18E02_29070	COG4134	Bacterial extracellular solute-binding protein
WP5W18E02_29090	COG4136	ATPase activity
WP5W18E02_29100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP5W18E02_29110	COG2951	lytic endotransglycosylase activity
WP5W18E02_29120	COG1846	Transcriptional regulator
WP5W18E02_29140	COG0033	Phosphoglucomutase
WP5W18E02_29150	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP5W18E02_29160	COG0596	Alpha beta hydrolase
WP5W18E02_29190	COG0716	FMN binding
WP5W18E02_29210	COG0735	belongs to the Fur family
WP5W18E02_29220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP5W18E02_29240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_29240	COG2190	(PTS) system
WP5W18E02_29240	COG1263	PTS System
WP5W18E02_29250	COG0363	glucosamine-6-phosphate deaminase activity
WP5W18E02_29260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP5W18E02_29270	COG1940	carbohydrate kinase activity
WP5W18E02_29270	COG1846	Transcriptional regulator
WP5W18E02_29280	COG2194	sulfuric ester hydrolase activity
WP5W18E02_29290	COG0217	transcriptional regulatory protein
WP5W18E02_29300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP5W18E02_29310	COG1801	Protein of unknown function DUF72
WP5W18E02_29320	COG4106	trans-aconitate 2-methyltransferase activity
WP5W18E02_29330	COG0500	methyltransferase
WP5W18E02_29370	COG0583	DNA-binding transcription factor activity
WP5W18E02_29380	COG0791	NLP P60 protein
WP5W18E02_29410	COG1309	transcriptional regulator
WP5W18E02_29480	COG0534	Mate efflux family protein
WP5W18E02_29500	COG2841	Protein conserved in bacteria
WP5W18E02_29510	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP5W18E02_29510	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP5W18E02_29510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP5W18E02_29510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP5W18E02_29530	COG3217	Mosc domain protein beta barrel domain protein
WP5W18E02_29530	COG3217	Mosc domain protein beta barrel domain protein
WP5W18E02_29530	COG0633	Ferredoxin
WP5W18E02_29530	COG0633	Ferredoxin
WP5W18E02_29540	COG0501	Belongs to the peptidase M48B family
WP5W18E02_29550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP5W18E02_29560	COG2226	methyltransferase
WP5W18E02_29560	COG1073	alpha beta
WP5W18E02_29570	COG0156	8-amino-7-oxononanoate synthase activity
WP5W18E02_29580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP5W18E02_29620	COG0017	Asparaginyl-tRNA synthetase
WP5W18E02_29630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP5W18E02_29650	COG1473	amidohydrolase
WP5W18E02_29660	COG3069	C4-dicarboxylate transmembrane transporter activity
WP5W18E02_29680	COG1393	Belongs to the ArsC family
WP5W18E02_29690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP5W18E02_29700	COG1876	peptidase activity
WP5W18E02_29720	COG3263	regulation of cellular component size
WP5W18E02_29740	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_29790	COG1957	nucleoside hydrolase
WP5W18E02_29820	COG1454	alcohol dehydrogenase
WP5W18E02_29830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP5W18E02_29840	COG0702	epimerase
WP5W18E02_29860	COG2867	negative regulation of translational initiation
WP5W18E02_29870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP5W18E02_29940	COG0246	Mannitol dehydrogenase
WP5W18E02_29950	COG2721	sulfolactate sulfo-lyase activity
WP5W18E02_29970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP5W18E02_29980	COG0800	Aldolase
WP5W18E02_30010	COG3153	acetyltransferase
WP5W18E02_30080	COG0259	pyridoxamine-phosphate oxidase activity
WP5W18E02_30100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP5W18E02_30100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP5W18E02_30110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP5W18E02_30140	COG0457	Tetratricopeptide repeat
WP5W18E02_30160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP5W18E02_30170	COG1138	Cytochrome C-type biogenesis protein
WP5W18E02_30180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP5W18E02_30190	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP5W18E02_30200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP5W18E02_30210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP5W18E02_30240	COG0835	chemotaxis
WP5W18E02_30260	COG1192	Involved in chromosome partitioning
WP5W18E02_30270	COG1360	Flagellar Motor Protein
WP5W18E02_30280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP5W18E02_30290	COG2201	protein-glutamate methylesterase activity
WP5W18E02_30300	COG0643	Histidine kinase
WP5W18E02_30300	COG0784	Response regulator, receiver
WP5W18E02_30300	COG2198	Histidine kinase
WP5W18E02_30310	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP5W18E02_30360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP5W18E02_30380	COG1684	flagellar biosynthetic protein fliR
WP5W18E02_30490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP5W18E02_30510	COG1677	Flagellar hook-basal body complex protein FliE
WP5W18E02_30540	COG1393	Belongs to the ArsC family
WP5W18E02_30550	COG0798	PFAM Bile acid sodium symporter
WP5W18E02_30560	COG0640	Transcriptional regulator
WP5W18E02_30580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP5W18E02_30610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP5W18E02_30620	COG0444	Belongs to the ABC transporter superfamily
WP5W18E02_30630	COG4608	Belongs to the ABC transporter superfamily
WP5W18E02_30650	COG2971	BadF BadG BcrA BcrD
WP5W18E02_30670	COG0840	transmembrane signaling receptor activity
WP5W18E02_30710	COG3724	N-succinylarginine dihydrolase activity
WP5W18E02_30720	COG0616	signal peptide processing
WP5W18E02_30730	COG1028	Short-chain dehydrogenase reductase Sdr
WP5W18E02_30740	COG0583	DNA-binding transcription factor activity
WP5W18E02_30770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP5W18E02_30790	COG0583	DNA-binding transcription factor activity
WP5W18E02_30810	COG1881	PFAM PEBP family protein
WP5W18E02_30830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP5W18E02_30840	COG0739	heme binding
WP5W18E02_30850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP5W18E02_30900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP5W18E02_30920	COG3091	SprT-like family
WP5W18E02_30940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP5W18E02_30950	COG0189	ligase activity
WP5W18E02_30970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP5W18E02_31010	COG1115	amino acid carrier protein
WP5W18E02_31020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP5W18E02_31050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP5W18E02_31070	COG1301	dicarboxylic acid transport
WP5W18E02_31080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP5W18E02_31090	COG2912	Transglutaminase-like superfamily
WP5W18E02_31110	COG2890	protein-(glutamine-N5) methyltransferase activity
WP5W18E02_31120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP5W18E02_31130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP5W18E02_31140	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP5W18E02_31150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP5W18E02_31160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP5W18E02_31170	COG0193	aminoacyl-tRNA hydrolase activity
WP5W18E02_31180	COG0012	GTP binding
WP5W18E02_31200	COG5377	YqaJ viral recombinase family
WP5W18E02_31290	COG2003	Belongs to the UPF0758 family
WP5W18E02_31400	COG1715	Restriction endonuclease
WP5W18E02_31420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP5W18E02_31470	COG3385	transposase activity
WP5W18E02_31520	COG3385	transposase activity
WP5W18E02_31650	COG0625	glutathione transferase activity
WP5W18E02_31660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP5W18E02_31700	COG1484	DNA-dependent DNA replication
WP5W18E02_31710	COG4584	PFAM Integrase catalytic
WP5W18E02_31770	COG3385	transposase activity
WP5W18E02_31810	COG0490	domain, Protein
WP5W18E02_31810	COG0471	metal ion transport
WP5W18E02_31860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP5W18E02_31890	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_31910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP5W18E02_31940	COG0180	Tryptophanyl-tRNA synthetase
WP5W18E02_31950	COG0546	phosphoglycolate phosphatase activity
WP5W18E02_31960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP5W18E02_31970	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP5W18E02_31990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP5W18E02_32000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP5W18E02_32060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP5W18E02_32070	COG0583	DNA-binding transcription factor activity
WP5W18E02_32100	COG0583	DNA-binding transcription factor activity
WP5W18E02_32120	COG0739	heme binding
WP5W18E02_32140	COG1511	domain protein
WP5W18E02_32140	COG3264	Mechanosensitive ion channel
WP5W18E02_32150	COG0584	glycerophosphoryl diester phosphodiesterase
WP5W18E02_32170	COG1053	succinate dehydrogenase
WP5W18E02_32180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP5W18E02_32190	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP5W18E02_32200	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP5W18E02_32230	COG3214	Protein conserved in bacteria
WP5W18E02_32240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP5W18E02_32280	COG0300	oxidoreductase activity
WP5W18E02_32320	COG4067	protein conserved in archaea
WP5W18E02_32320	COG0189	ligase activity
WP5W18E02_32330	COG0516	GMP reductase activity
WP5W18E02_32350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP5W18E02_32360	COG2011	ABC-type metal ion transport system permease component
WP5W18E02_32370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP5W18E02_32380	COG1464	Belongs to the NlpA lipoprotein family
WP5W18E02_32410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP5W18E02_32430	COG3706	GGDEF domain
WP5W18E02_32460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP5W18E02_32490	COG1335	isochorismatase
WP5W18E02_32500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP5W18E02_32510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP5W18E02_32520	COG1702	phosphate starvation-inducible protein PhoH
WP5W18E02_32530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP5W18E02_32540	COG4535	Mg2 and Co2 transporter CorC
WP5W18E02_32550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP5W18E02_32560	COG2888	peptidyl-tyrosine sulfation
WP5W18E02_32570	COG0495	leucyl-tRNA aminoacylation
WP5W18E02_32600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP5W18E02_32610	COG0799	negative regulation of ribosome biogenesis
WP5W18E02_32620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP5W18E02_32630	COG0768	penicillin binding
WP5W18E02_32640	COG0772	Belongs to the SEDS family
WP5W18E02_32650	COG2951	lytic endotransglycosylase activity
WP5W18E02_32660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP5W18E02_32670	COG1686	Belongs to the peptidase S11 family
WP5W18E02_32680	COG2921	Belongs to the UPF0250 family
WP5W18E02_32690	COG0321	lipoyl(octanoyl) transferase activity
WP5W18E02_32710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP5W18E02_32730	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP5W18E02_32760	COG0789	Transcriptional regulator
WP5W18E02_32770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP5W18E02_32790	COG1970	mechanosensitive ion channel activity
WP5W18E02_32800	COG4974	Belongs to the 'phage' integrase family
WP5W18E02_32820	COG0312	modulator of DNA gyrase
WP5W18E02_32830	COG0312	modulator of DNA gyrase
WP5W18E02_32870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP5W18E02_32880	COG1422	Protein of unknown function (DUF1090)
WP5W18E02_32890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP5W18E02_32900	COG2211	Major facilitator Superfamily
WP5W18E02_32910	COG1185	polyribonucleotide nucleotidyltransferase activity
WP5W18E02_32920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP5W18E02_32930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP5W18E02_32940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP5W18E02_32950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP5W18E02_32960	COG0195	Participates in both transcription termination and antitermination
WP5W18E02_32970	COG0779	Required for maturation of 30S ribosomal subunits
WP5W18E02_32980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP5W18E02_32990	COG0149	triose-phosphate isomerase activity
WP5W18E02_33000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP5W18E02_33010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP5W18E02_33030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP5W18E02_33040	COG1534	Rna-binding protein
WP5W18E02_33070	COG1360	Flagellar Motor Protein
WP5W18E02_33080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP5W18E02_33090	COG1722	exodeoxyribonuclease VII activity
WP5W18E02_33100	COG0142	geranyltranstransferase activity
WP5W18E02_33110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP5W18E02_33150	COG4172	Belongs to the ABC transporter superfamily
WP5W18E02_33160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP5W18E02_33170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP5W18E02_33180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP5W18E02_33190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP5W18E02_33220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP5W18E02_33220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP5W18E02_33230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP5W18E02_33250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP5W18E02_33270	COG3381	protein complex oligomerization
WP5W18E02_33300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP5W18E02_33310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP5W18E02_33320	COG0511	ligase activity, forming carbon-carbon bonds
WP5W18E02_33330	COG0439	Biotin carboxylase
WP5W18E02_33340	COG3924	membrane
WP5W18E02_33350	COG4145	pantothenate transmembrane transporter activity
WP5W18E02_33360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP5W18E02_33360	COG1263	PTS System
WP5W18E02_33360	COG2190	(PTS) system
WP5W18E02_33370	COG0583	DNA-binding transcription factor activity
WP5W18E02_33380	COG0604	alcohol dehydrogenase
WP5W18E02_33390	COG2264	protein methyltransferase activity
WP5W18E02_33400	COG0110	maltose O-acetyltransferase activity
WP5W18E02_33430	COG0778	Nitroreductase
WP5W18E02_33440	COG1902	pentaerythritol trinitrate reductase activity
WP5W18E02_33440	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP5W18E02_33450	COG0616	signal peptide processing
WP5W18E02_33490	COG3139	Protein of unknown function (DUF1315)
WP5W18E02_33500	COG0252	asparaginase activity
WP5W18E02_33510	COG0786	glutamate:sodium symporter activity
WP5W18E02_33530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP5W18E02_33540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP5W18E02_33550	COG0384	phenazine biosynthesis protein PhzF
WP5W18E02_33560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP5W18E02_33570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP5W18E02_33580	COG0175	sulfate reduction
WP5W18E02_33590	COG2113	Glycine betaine
WP5W18E02_33600	COG4176	ABC-type proline glycine betaine transport system permease component
WP5W18E02_33610	COG4175	Glycine betaine
WP5W18E02_33630	COG3610	response to peptide
WP5W18E02_33650	COG2966	Psort location CytoplasmicMembrane, score
WP5W18E02_33670	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP5W18E02_33730	COG2313	pseudouridylate synthase activity
WP5W18E02_33740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP5W18E02_33750	COG2146	nitrite reductase [NAD(P)H] activity
WP5W18E02_33750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP5W18E02_33760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP5W18E02_33760	COG2146	nitrite reductase [NAD(P)H] activity
WP5W18E02_33770	COG1116	anion transmembrane transporter activity
WP5W18E02_33780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP5W18E02_33790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP5W18E02_33790	COG1116	anion transmembrane transporter activity
WP5W18E02_33810	COG1648	precorrin-2 dehydrogenase activity
WP5W18E02_33810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP5W18E02_33820	COG0243	molybdopterin cofactor binding
WP5W18E02_33880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP5W18E02_33920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP5W18E02_33940	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP5W18E02_33960	COG4608	Belongs to the ABC transporter superfamily
WP5W18E02_33970	COG0444	Belongs to the ABC transporter superfamily
WP5W18E02_33990	COG4239	(ABC) transporter, permease
WP5W18E02_34000	COG4174	ABC transporter (Permease)
WP5W18E02_34010	COG4206	TonB-dependent receptor
WP5W18E02_34030	COG0811	peptide transport
WP5W18E02_34040	COG0811	peptide transport
WP5W18E02_34050	COG0848	biopolymer transport protein
WP5W18E02_34110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP5W18E02_34120	COG0840	transmembrane signaling receptor activity
WP5W18E02_34140	COG1278	Cold shock
WP5W18E02_34150	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP5W18E02_34160	COG1162	GTPase activity
WP5W18E02_34170	COG0688	phosphatidylethanolamine metabolic process
WP5W18E02_34180	COG4628	conserved protein (DUF2132)
WP5W18E02_34220	COG3300	MHYT domain
WP5W18E02_34220	COG5001	Diguanylate cyclase
WP5W18E02_34230	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP5W18E02_34270	COG1132	(ABC) transporter
WP5W18E02_34290	COG2897	thiosulfate sulfurtransferase activity
WP5W18E02_34300	COG2066	Belongs to the glutaminase family
WP5W18E02_34310	COG3171	Protein conserved in bacteria
WP5W18E02_34320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP5W18E02_34330	COG4935	Belongs to the peptidase S8 family
WP5W18E02_34330	COG2234	aminopeptidase activity
WP5W18E02_34340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP5W18E02_34350	COG2200	EAL domain
WP5W18E02_34360	COG1090	epimerase
WP5W18E02_34370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP5W18E02_34380	COG4181	ATPase activity
WP5W18E02_34390	COG2755	lipolytic protein G-D-S-L family
WP5W18E02_34400	COG0835	chemotaxis
WP5W18E02_34400	COG0784	Response regulator, receiver
WP5W18E02_34420	COG0675	Transposase, IS605 OrfB family
WP5W18E02_34440	COG0516	GMP reductase activity
WP5W18E02_34440	COG0517	IMP dehydrogenase activity
WP5W18E02_34450	COG0488	(ABC) transporter
WP5W18E02_34470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP5W18E02_34550	COG3039	Transposase
WP5W18E02_34570	COG0789	Transcriptional regulator
WP5W18E02_34590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP5W18E02_34610	COG0668	transmembrane transport
WP5W18E02_34630	COG2731	YhcH YjgK YiaL family protein
WP5W18E02_34650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP5W18E02_34660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP5W18E02_34670	COG3227	Zinc metalloprotease (Elastase)
WP5W18E02_34680	COG0583	DNA-binding transcription factor activity
WP5W18E02_34690	COG0477	Major facilitator Superfamily
WP5W18E02_34890	COG2985	domain, Protein
WP5W18E02_34890	COG0569	domain protein
WP5W18E02_34900	COG1272	protein, Hemolysin III
WP5W18E02_34920	COG2917	probably involved in intracellular septation
WP5W18E02_34930	COG2350	Protein conserved in bacteria
WP5W18E02_34950	COG1555	photosystem II stabilization
WP5W18E02_34960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP5W18E02_34970	COG3104	oligopeptide transport
WP5W18E02_34980	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_35040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_35060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP5W18E02_35070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP5W18E02_35140	COG2205	protein histidine kinase activity
WP5W18E02_35150	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_35160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_35170	COG0577	efflux transmembrane transporter activity
WP5W18E02_35170	COG1136	(ABC) transporter
WP5W18E02_35190	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP5W18E02_35260	COG2199	diguanylate cyclase activity
WP5W18E02_35260	COG2203	Gaf domain
WP5W18E02_35270	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_35290	COG2207	Transcriptional regulator
WP5W18E02_35290	COG1917	Cupin 2, conserved barrel domain protein
WP5W18E02_35330	COG3039	Transposase
WP5W18E02_35350	COG0154	amidase activity
WP5W18E02_35360	COG2957	Belongs to the agmatine deiminase family
WP5W18E02_35380	COG2852	Protein conserved in bacteria
WP5W18E02_35400	COG1902	pentaerythritol trinitrate reductase activity
WP5W18E02_35410	COG0456	acetyltransferase
WP5W18E02_35430	COG0456	acetyltransferase
WP5W18E02_35470	COG5001	Diguanylate cyclase
WP5W18E02_35470	COG5002	protein histidine kinase activity
WP5W18E02_35480	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP5W18E02_35510	COG0456	acetyltransferase
WP5W18E02_35530	COG1022	Amp-dependent synthetase and ligase
WP5W18E02_35550	COG1794	racemase activity, acting on amino acids and derivatives
WP5W18E02_35580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP5W18E02_35610	COG0733	neurotransmitter:sodium symporter activity
WP5W18E02_35620	COG0733	neurotransmitter:sodium symporter activity
WP5W18E02_35650	COG0561	phosphatase activity
WP5W18E02_35710	COG1846	Transcriptional regulator
WP5W18E02_35720	COG2130	NADP-dependent
WP5W18E02_35780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP5W18E02_35790	COG1640	4-alpha-glucanotransferase
WP5W18E02_35800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP5W18E02_35820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP5W18E02_35830	COG0840	transmembrane signaling receptor activity
WP5W18E02_35840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP5W18E02_35850	COG2885	chlorophyll binding
WP5W18E02_35860	COG0823	Involved in the tonB-independent uptake of proteins
WP5W18E02_35890	COG0811	peptide transport
WP5W18E02_35900	COG0824	Thioesterase
WP5W18E02_35910	COG3790	cyd operon protein YbgE
WP5W18E02_35920	COG4890	Cyd operon protein YbgT
WP5W18E02_35930	COG1294	oxidase, subunit
WP5W18E02_35940	COG1271	oxidase subunit
WP5W18E02_35950	COG2255	four-way junction helicase activity
WP5W18E02_35960	COG0632	four-way junction helicase activity
WP5W18E02_35970	COG0840	transmembrane signaling receptor activity
WP5W18E02_35980	COG0442	prolyl-tRNA aminoacylation
WP5W18E02_35990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP5W18E02_36000	COG4221	oxidoreductase activity
WP5W18E02_36010	COG4221	oxidoreductase activity
WP5W18E02_36020	COG4221	oxidoreductase activity
WP5W18E02_36050	COG1024	Enoyl-CoA hydratase
WP5W18E02_36080	COG4166	transmembrane transport
WP5W18E02_36100	COG0840	transmembrane signaling receptor activity
WP5W18E02_36110	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_36180	COG3118	belongs to the thioredoxin family
WP5W18E02_36180	COG0457	Tetratricopeptide repeat
WP5W18E02_36230	COG2194	sulfuric ester hydrolase activity
WP5W18E02_36240	COG1448	Aminotransferase
WP5W18E02_36270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP5W18E02_36280	COG1328	CTP reductase activity
WP5W18E02_36330	COG0840	transmembrane signaling receptor activity
WP5W18E02_36340	COG3397	chitin binding
WP5W18E02_36350	COG0583	DNA-binding transcription factor activity
WP5W18E02_36360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP5W18E02_36370	COG4208	sulfate ABC transporter
WP5W18E02_36380	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP5W18E02_36400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP5W18E02_36410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP5W18E02_36420	COG0564	pseudouridine synthase activity
WP5W18E02_36460	COG0459	protein refolding
WP5W18E02_36470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP5W18E02_36480	COG0534	Mate efflux family protein
WP5W18E02_36490	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP5W18E02_36500	COG1027	Aspartate ammonia-lyase
WP5W18E02_36510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP5W18E02_36520	COG2918	glutathione biosynthetic process
WP5W18E02_36530	COG0612	Peptidase, M16
WP5W18E02_36540	COG1238	metal cluster binding
WP5W18E02_36610	COG0359	binds to the 23S rRNA
WP5W18E02_36620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP5W18E02_36630	COG0360	Binds together with S18 to 16S ribosomal RNA
WP5W18E02_36650	COG1914	H( )-stimulated, divalent metal cation uptake system
WP5W18E02_36660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP5W18E02_36670	COG2153	protein acetylation
WP5W18E02_36690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP5W18E02_36700	COG0557	exoribonuclease II activity
WP5W18E02_36710	COG3706	GGDEF domain
WP5W18E02_36720	COG1854	S-ribosylhomocysteine lyase activity
WP5W18E02_36750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP5W18E02_36750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP5W18E02_36840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP5W18E02_36850	COG1047	Peptidyl-prolyl cis-trans
WP5W18E02_36860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP5W18E02_36870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP5W18E02_36880	COG0196	riboflavin kinase activity
WP5W18E02_36890	COG0728	peptidoglycan biosynthetic process
WP5W18E02_36900	COG0268	Binds directly to 16S ribosomal RNA
WP5W18E02_36910	COG0640	Transcriptional regulator
WP5W18E02_36920	COG0583	DNA-binding transcription factor activity
WP5W18E02_36940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP5W18E02_36950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP5W18E02_36960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP5W18E02_36980	COG1051	belongs to the nudix hydrolase family
WP5W18E02_37020	COG0335	large ribosomal subunit rRNA binding
WP5W18E02_37030	COG0336	Belongs to the RNA methyltransferase TrmD family
WP5W18E02_37040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP5W18E02_37050	COG0228	four-way junction DNA binding
WP5W18E02_37060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP5W18E02_37070	COG4137	Cytochrome C assembly protein
WP5W18E02_37080	COG4536	flavin adenine dinucleotide binding
WP5W18E02_37100	COG1017	nitric oxide dioxygenase activity
WP5W18E02_37100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP5W18E02_37110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP5W18E02_37120	COG0039	L-malate dehydrogenase activity
WP5W18E02_37130	COG4160	amino acid transport
WP5W18E02_37140	COG4215	(ABC) transporter
WP5W18E02_37150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP5W18E02_37160	COG1126	abc transporter atp-binding protein
WP5W18E02_37170	COG1438	arginine binding
WP5W18E02_37180	COG2837	iron assimilation
WP5W18E02_37190	COG3842	ATPase activity
WP5W18E02_37220	COG0347	Belongs to the P(II) protein family
WP5W18E02_37250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP5W18E02_37260	COG0583	DNA-binding transcription factor activity
WP5W18E02_37290	COG1929	Belongs to the glycerate kinase type-1 family
WP5W18E02_37300	COG2610	gluconate transmembrane transporter activity
WP5W18E02_37310	COG3835	regulator
WP5W18E02_37320	COG3112	Uncharacterised protein family (UPF0231)
WP5W18E02_37360	COG1872	DUF167
WP5W18E02_37370	COG0762	integral membrane protein
WP5W18E02_37380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP5W18E02_37390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP5W18E02_37410	COG2805	Type II/IV secretion system protein
WP5W18E02_37420	COG3022	response to hydroperoxide
WP5W18E02_37430	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_37440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP5W18E02_37480	COG0735	belongs to the Fur family
WP5W18E02_37490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP5W18E02_37520	COG0776	regulation of translation
WP5W18E02_37530	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP5W18E02_37550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP5W18E02_37580	COG0560	Phosphoserine phosphatase
WP5W18E02_37600	COG5002	protein histidine kinase activity
WP5W18E02_37600	COG3447	MASE1 domain protein
WP5W18E02_37600	COG5001	Diguanylate cyclase
WP5W18E02_37610	COG0813	purine-nucleoside phosphorylase activity
WP5W18E02_37620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP5W18E02_37630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP5W18E02_37640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP5W18E02_37660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP5W18E02_37670	COG0084	hydrolase, TatD family'
WP5W18E02_37720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP5W18E02_37730	COG0004	ammonium transporteR
WP5W18E02_37760	COG2801	Transposase and inactivated derivatives
WP5W18E02_37770	COG0582	viral genome integration into host DNA
WP5W18E02_37780	COG4974	Belongs to the 'phage' integrase family
WP5W18E02_37800	COG2932	Transcriptional regulator
WP5W18E02_37990	COG4695	Portal protein
WP5W18E02_38240	COG0795	lipopolysaccharide-transporting ATPase activity
WP5W18E02_38250	COG0795	lipopolysaccharide-transporting ATPase activity
WP5W18E02_38260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP5W18E02_38270	COG2927	DNA polymerase III (CHI subunit)
WP5W18E02_38280	COG0525	valine-tRNA ligase activity
WP5W18E02_38290	COG1253	flavin adenine dinucleotide binding
WP5W18E02_38300	COG0586	Pfam SNARE associated Golgi protein
WP5W18E02_38310	COG1686	Belongs to the peptidase S11 family
WP5W18E02_38320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP5W18E02_38330	COG0527	aspartate kinase activity
WP5W18E02_38340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP5W18E02_38350	COG2137	regulation of response to DNA damage stimulus
WP5W18E02_38360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP5W18E02_38370	COG1546	Belongs to the CinA family
WP5W18E02_38390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP5W18E02_38440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP5W18E02_38450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP5W18E02_38480	COG0477	Major facilitator Superfamily
WP5W18E02_38490	COG0523	cobalamin synthesis protein
WP5W18E02_38510	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_38530	COG2200	EAL domain
WP5W18E02_38540	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP5W18E02_38550	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP5W18E02_38560	COG0840	transmembrane signaling receptor activity
WP5W18E02_38570	COG0840	transmembrane signaling receptor activity
WP5W18E02_38590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP5W18E02_38600	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP5W18E02_38610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP5W18E02_38620	COG2186	Transcriptional regulator
WP5W18E02_38660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP5W18E02_38670	COG1459	type II secretion system
WP5W18E02_38700	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP5W18E02_38710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP5W18E02_38720	COG0494	nUDIX hydrolase
WP5W18E02_38740	COG0653	protein targeting
WP5W18E02_38760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP5W18E02_38770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP5W18E02_38780	COG0849	cell division
WP5W18E02_38790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP5W18E02_38800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP5W18E02_38810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP5W18E02_38820	COG0772	Belongs to the SEDS family
WP5W18E02_38830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP5W18E02_38840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP5W18E02_38850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP5W18E02_38860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP5W18E02_38870	COG0768	penicillin binding
WP5W18E02_38880	COG3116	cell division
WP5W18E02_38890	COG0275	rRNA processing
WP5W18E02_38900	COG2001	Belongs to the MraZ family
WP5W18E02_38910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP5W18E02_38920	COG3107	peptidoglycan biosynthetic process
WP5W18E02_38930	COG0792	nuclease activity
WP5W18E02_38940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP5W18E02_38950	COG2823	Periplasmic or secreted lipoprotein
WP5W18E02_38960	COG2969	positive regulation of protein catabolic process
WP5W18E02_38970	COG0625	glutathione transferase activity
WP5W18E02_38980	COG2857	Cytochrome c1
WP5W18E02_38990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP5W18E02_39000	COG0723	plastoquinol--plastocyanin reductase activity
WP5W18E02_39010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP5W18E02_39020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP5W18E02_39030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP5W18E02_39050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP5W18E02_39060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP5W18E02_39120	COG3964	amidohydrolase
WP5W18E02_39160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_39170	COG1660	Displays ATPase and GTPase activities
WP5W18E02_39180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP5W18E02_39200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP5W18E02_39210	COG1137	ATPase activity
WP5W18E02_39220	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP5W18E02_39240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP5W18E02_39250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP5W18E02_39250	COG0517	IMP dehydrogenase activity
WP5W18E02_39260	COG1127	ABC transporter
WP5W18E02_39270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP5W18E02_39280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP5W18E02_39290	COG2854	intermembrane phospholipid transfer
WP5W18E02_39310	COG5007	Belongs to the BolA IbaG family
WP5W18E02_39320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP5W18E02_39340	COG1494	fructose-1,6-bisphosphatase
WP5W18E02_39360	COG2226	methyltransferase
WP5W18E02_39390	COG4773	Receptor
WP5W18E02_39420	COG1733	regulation of RNA biosynthetic process
WP5W18E02_39450	COG3932	Exopolysaccharide synthesis, ExoD
WP5W18E02_39460	COG2199	diguanylate cyclase activity
WP5W18E02_39460	COG2203	Gaf domain
WP5W18E02_39480	COG0110	maltose O-acetyltransferase activity
WP5W18E02_39520	COG3415	Transposase
WP5W18E02_39520	COG2801	Transposase and inactivated derivatives
WP5W18E02_39530	COG3385	transposase activity
WP5W18E02_39540	COG2801	Transposase and inactivated derivatives
WP5W18E02_39550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP5W18E02_39560	COG2022	thiamine diphosphate biosynthetic process
WP5W18E02_39580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP5W18E02_39590	COG0352	thiamine-phosphate diphosphorylase activity
WP5W18E02_39600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP5W18E02_39630	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_39640	COG0642	Histidine kinase
WP5W18E02_39650	COG0189	ligase activity
WP5W18E02_39720	COG2321	neutral zinc metallopeptidase
WP5W18E02_39740	COG0477	Major facilitator Superfamily
WP5W18E02_39770	COG0312	modulator of DNA gyrase
WP5W18E02_39780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP5W18E02_39790	COG3164	Protein of unknown function
WP5W18E02_39800	COG1530	ribonuclease E activity
WP5W18E02_39810	COG0424	maF-like protein
WP5W18E02_39820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP5W18E02_39830	COG1792	Involved in formation and maintenance of cell shape
WP5W18E02_39840	COG1077	Cell shape determining protein MreB Mrl
WP5W18E02_39930	COG1459	type II secretion system
WP5W18E02_40050	COG2200	EAL domain
WP5W18E02_40060	COG0387	Pfam Sodium calcium exchanger
WP5W18E02_40070	COG2986	histidine ammonia-lyase
WP5W18E02_40080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP5W18E02_40090	COG0010	Belongs to the arginase family
WP5W18E02_40100	COG1228	amidohydrolase
WP5W18E02_40110	COG2188	Transcriptional regulator
WP5W18E02_40120	COG0288	reversible hydration of carbon dioxide
WP5W18E02_40140	COG2177	Part of the ABC transporter FtsEX involved in
WP5W18E02_40150	COG2884	Cell division ATP-binding protein ftsE
WP5W18E02_40160	COG0552	protein localization to endoplasmic reticulum
WP5W18E02_40170	COG0742	ribosomal rna small subunit methyltransferase
WP5W18E02_40220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP5W18E02_40240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP5W18E02_40260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP5W18E02_40280	COG2095	MarC family integral membrane protein
WP5W18E02_40300	COG1301	dicarboxylic acid transport
WP5W18E02_40320	COG0583	DNA-binding transcription factor activity
WP5W18E02_40350	COG3714	YhhN family
WP5W18E02_40380	COG2358	TRAP transporter, solute receptor (TAXI family
WP5W18E02_40390	COG1770	oligopeptidase
WP5W18E02_40420	COG4221	oxidoreductase activity
WP5W18E02_40430	COG0583	DNA-binding transcription factor activity
WP5W18E02_40440	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP5W18E02_40490	COG2801	Transposase and inactivated derivatives
WP5W18E02_40500	COG0203	ribosomal protein L17
WP5W18E02_40510	COG0202	RNA polymerase activity
WP5W18E02_40520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP5W18E02_40530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP5W18E02_40540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP5W18E02_40550	COG0201	protein transport
WP5W18E02_40560	COG0200	Binds to the 23S rRNA
WP5W18E02_40570	COG1841	ribosomal large subunit assembly
WP5W18E02_40580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP5W18E02_40590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP5W18E02_40600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP5W18E02_40610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP5W18E02_40620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP5W18E02_40630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP5W18E02_40640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP5W18E02_40650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP5W18E02_40660	COG0255	Belongs to the universal ribosomal protein uL29 family
WP5W18E02_40670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP5W18E02_40680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP5W18E02_40690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP5W18E02_40700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP5W18E02_40710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP5W18E02_40720	COG0089	rRNA binding
WP5W18E02_40730	COG0088	Forms part of the polypeptide exit tunnel
WP5W18E02_40740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP5W18E02_40750	COG0051	transcription antitermination factor activity, RNA binding
WP5W18E02_40770	COG2205	protein histidine kinase activity
WP5W18E02_40780	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_40790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP5W18E02_40800	COG2183	response to ionizing radiation
WP5W18E02_40830	COG0596	Alpha beta hydrolase
WP5W18E02_40840	COG1040	competence protein
WP5W18E02_40850	COG0316	Belongs to the HesB IscA family
WP5W18E02_40850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP5W18E02_40860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP5W18E02_40870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP5W18E02_40880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP5W18E02_40890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP5W18E02_40900	COG4942	peptidase
WP5W18E02_40920	COG1609	Transcriptional regulator
WP5W18E02_40950	COG0800	Aldolase
WP5W18E02_40960	COG0129	dihydroxy-acid dehydratase activity
WP5W18E02_40970	COG3265	gluconokinase activity
WP5W18E02_40980	COG2610	gluconate transmembrane transporter activity
WP5W18E02_40990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP5W18E02_41000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP5W18E02_41020	COG0456	acetyltransferase
WP5W18E02_41050	COG1490	D-aminoacyl-tRNA deacylase activity
WP5W18E02_41060	COG1295	ribonuclease BN
WP5W18E02_41080	COG0174	glutamine synthetase
WP5W18E02_41100	COG3852	Histidine kinase
WP5W18E02_41120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP5W18E02_41130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP5W18E02_41150	COG3078	GTPase activator activity
WP5W18E02_41170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP5W18E02_41180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP5W18E02_41190	COG0408	coproporphyrinogen oxidase activity
WP5W18E02_41200	COG0009	L-threonylcarbamoyladenylate synthase
WP5W18E02_41210	COG0551	DNA topoisomerase type I activity
WP5W18E02_41220	COG2922	Belongs to the Smg family
WP5W18E02_41230	COG0758	DNA mediated transformation
WP5W18E02_41250	COG0242	peptide deformylase activity
WP5W18E02_41260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP5W18E02_41270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP5W18E02_41270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP5W18E02_41280	COG0569	domain protein
WP5W18E02_41290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP5W18E02_41300	COG1322	Protein conserved in bacteria
WP5W18E02_41340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP5W18E02_41360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP5W18E02_41360	COG0519	Catalyzes the synthesis of GMP from XMP
WP5W18E02_41390	COG1396	sequence-specific DNA binding
WP5W18E02_41400	COG1012	belongs to the aldehyde dehydrogenase family
WP5W18E02_41420	COG2962	Rard protein
WP5W18E02_41440	COG1280	lysine exporter protein (LysE YggA)
WP5W18E02_41470	COG0583	DNA-binding transcription factor activity
WP5W18E02_41540	COG0583	DNA-binding transcription factor activity
WP5W18E02_41550	COG1943	Transposase
WP5W18E02_41570	COG3039	Transposase
WP5W18E02_41580	COG0210	DNA helicase
WP5W18E02_41650	COG0583	DNA-binding transcription factor activity
WP5W18E02_41700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP5W18E02_41710	COG0385	Bile acid
WP5W18E02_41720	COG0531	amino acid
WP5W18E02_41730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP5W18E02_41740	COG0531	amino acid
WP5W18E02_41750	COG2731	YhcH YjgK YiaL family protein
WP5W18E02_41760	COG3250	beta-galactosidase activity
WP5W18E02_41770	COG1609	Transcriptional regulator
WP5W18E02_41780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP5W18E02_41790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP5W18E02_41790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP5W18E02_41800	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP5W18E02_41810	COG3074	FtsZ-dependent cytokinesis
WP5W18E02_41830	COG1045	serine acetyltransferase
WP5W18E02_41850	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_41860	COG2205	protein histidine kinase activity
WP5W18E02_41870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP5W18E02_41880	COG0534	Mate efflux family protein
WP5W18E02_41910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP5W18E02_41920	COG2937	Belongs to the GPAT DAPAT family
WP5W18E02_41930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP5W18E02_41940	COG3161	chorismate lyase activity
WP5W18E02_41950	COG1580	Controls the rotational direction of flagella during chemotaxis
WP5W18E02_41990	COG1609	Transcriptional regulator
WP5W18E02_42080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP5W18E02_42100	COG0156	8-amino-7-oxononanoate synthase activity
WP5W18E02_42110	COG1063	alcohol dehydrogenase
WP5W18E02_42150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP5W18E02_42160	COG2166	iron-sulfur cluster assembly
WP5W18E02_42170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP5W18E02_42190	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP5W18E02_42200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP5W18E02_42210	COG1739	Uncharacterized protein family UPF0029
WP5W18E02_42220	COG0006	proline dipeptidase activity
WP5W18E02_42230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP5W18E02_42240	COG1024	Enoyl-CoA hydratase
WP5W18E02_42240	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP5W18E02_42250	COG0183	Belongs to the thiolase family
WP5W18E02_42260	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_42300	COG0425	Belongs to the sulfur carrier protein TusA family
WP5W18E02_42310	COG0251	oxidation-reduction process
WP5W18E02_42330	COG2885	chlorophyll binding
WP5W18E02_42360	COG2818	Glycosylase
WP5W18E02_42370	COG0752	glycyl-tRNA synthetase alpha subunit
WP5W18E02_42380	COG0751	glycine-tRNA ligase activity
WP5W18E02_42390	COG3039	Transposase
WP5W18E02_42410	COG3706	GGDEF domain
WP5W18E02_42410	COG4251	negative regulation of phosphorylation
WP5W18E02_42410	COG5001	Diguanylate cyclase
WP5W18E02_42410	COG2203	Gaf domain
WP5W18E02_42440	COG0814	amino acid
WP5W18E02_42450	COG0814	amino acid
WP5W18E02_42460	COG3033	Beta-eliminating lyase
WP5W18E02_42470	COG0348	domain, Protein
WP5W18E02_42490	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP5W18E02_42500	COG1773	rubredoxin
WP5W18E02_42500	COG0426	domain, Protein
WP5W18E02_42510	COG3604	Transcriptional regulator
WP5W18E02_42520	COG1609	Transcriptional regulator
WP5W18E02_42600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP5W18E02_42630	COG2960	long-chain fatty acid transporting porin activity
WP5W18E02_42650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP5W18E02_42680	COG3118	belongs to the thioredoxin family
WP5W18E02_42690	COG0513	Belongs to the DEAD box helicase family
WP5W18E02_42700	COG0248	Ppx GppA phosphatase
WP5W18E02_42720	COG0742	ribosomal rna small subunit methyltransferase
WP5W18E02_42760	COG0084	hydrolase, TatD family'
WP5W18E02_42770	COG0805	protein transport
WP5W18E02_42780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP5W18E02_42790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP5W18E02_42800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP5W18E02_42810	COG3165	ubiquinone biosynthetic process from chorismate
WP5W18E02_42830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP5W18E02_42840	COG0402	S-adenosylhomocysteine deaminase activity
WP5W18E02_42870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP5W18E02_42880	COG0848	biopolymer transport protein
WP5W18E02_42890	COG0811	peptide transport
WP5W18E02_42900	COG0811	peptide transport
WP5W18E02_42920	COG2771	luxR family
WP5W18E02_42930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP5W18E02_42940	COG1349	DNA-binding transcription factor activity
WP5W18E02_42950	COG0745	RESPONSE REGULATOR receiver
WP5W18E02_42960	COG2205	protein histidine kinase activity
WP5W18E02_42980	COG4452	Inner membrane protein CreD
WP5W18E02_42990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP5W18E02_43000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP5W18E02_43010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP5W18E02_43020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP5W18E02_43030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP5W18E02_43040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP5W18E02_43050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP5W18E02_43070	COG0356	it plays a direct role in the translocation of protons across the membrane
WP5W18E02_43090	COG1475	DNA binding
WP5W18E02_43100	COG1192	Involved in chromosome partitioning
WP5W18E02_43110	COG0357	Ribosomal RNA small subunit methyltransferase G
WP5W18E02_43120	COG0445	tRNA wobble uridine modification
WP5W18E02_43130	COG0716	FMN binding
WP5W18E02_43140	COG4774	siderophore transport
WP5W18E02_43150	COG4615	Cyclic peptide transporter
WP5W18E02_43160	COG1120	ATPase activity
WP5W18E02_43170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP5W18E02_43190	COG3550	peptidyl-serine autophosphorylation
WP5W18E02_43210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP5W18E02_43220	COG3041	Addiction module toxin RelE StbE family
WP5W18E02_43340	COG4372	Transposase
WP5W18E02_43350	COG2801	Transposase and inactivated derivatives
WP5W18E02_43520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP5W18E02_43600	COG3645	SOS response
WP5W18E02_43660	COG4974	Belongs to the 'phage' integrase family
WP5W18E02_43670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP5W18E02_43680	COG0706	membrane insertase activity
WP5W18E02_43690	COG0594	ribonuclease P activity
WP5W18E02_43700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP5W18E02_P10010	COG2026	Addiction module toxin, RelE StbE family
WP5W18E02_P10020	COG2801	Transposase and inactivated derivatives
WP5W18E02_P10120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP5W18E02_P10180	COG4584	PFAM Integrase catalytic
WP5W18E02_P10200	COG4584	PFAM Integrase catalytic
WP5W18E02_P10210	COG1484	DNA-dependent DNA replication
WP5W18E02_P10240	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP5W18E02_P10260	COG1192	Involved in chromosome partitioning
WP5W18E02_P10620	COG2003	Belongs to the UPF0758 family
WP5W18E02_P10750	COG3344	reverse transcriptase
WP5W18E02_P10810	COG5433	transposase activity
WP5W18E02_P10830	COG5433	transposase activity
WP5W18E02_P10860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP5W18E02_P10870	COG4584	PFAM Integrase catalytic
WP5W18E02_P11020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP5W18E02_P11050	COG4584	PFAM Integrase catalytic
WP5W18E02_P11060	COG1484	DNA-dependent DNA replication
WP5W18E02_P11090	COG1192	Involved in chromosome partitioning
WP5W18E02_P11150	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP5W18E02_P11170	COG1192	Involved in chromosome partitioning
WP5W18E02_P11270	COG1192	Involved in chromosome partitioning