locus-tag	class	description
WP8S17E03_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP8S17E03_00020	COG0592	DNA-directed DNA polymerase activity
WP8S17E03_00040	COG0187	DNA topoisomerase II activity
WP8S17E03_00050	COG2207	Transcriptional regulator
WP8S17E03_00070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP8S17E03_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S17E03_00090	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S17E03_00100	COG3977	Valine--pyruvate aminotransferase
WP8S17E03_00130	COG2814	Major facilitator Superfamily
WP8S17E03_00140	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_00150	COG2205	protein histidine kinase activity
WP8S17E03_00190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S17E03_00200	COG4191	Histidine kinase
WP8S17E03_00200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_00210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_00230	COG1309	transcriptional regulator
WP8S17E03_00250	COG0561	phosphatase activity
WP8S17E03_00260	COG2267	carboxylic ester hydrolase activity
WP8S17E03_00280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S17E03_00290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S17E03_00300	COG1758	RNA polymerase activity
WP8S17E03_00320	COG0859	PFAM glycosyl transferase family 9
WP8S17E03_00330	COG3642	lipopolysaccharide core region biosynthetic process
WP8S17E03_00410	COG0589	response to stress
WP8S17E03_00420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8S17E03_00430	COG3706	GGDEF domain
WP8S17E03_00440	COG1528	Iron-storage protein
WP8S17E03_00450	COG2081	HI0933 family
WP8S17E03_00460	COG2223	nitrite transmembrane transporter activity
WP8S17E03_00470	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_00500	COG3188	usher protein
WP8S17E03_00540	COG3039	Transposase
WP8S17E03_00560	COG2205	protein histidine kinase activity
WP8S17E03_00560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_00580	COG3275	phosphorelay sensor kinase activity
WP8S17E03_00590	COG3279	Response regulator of the LytR AlgR family
WP8S17E03_00600	COG2223	nitrite transmembrane transporter activity
WP8S17E03_00610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP8S17E03_00620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP8S17E03_00670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP8S17E03_00680	COG2166	iron-sulfur cluster assembly
WP8S17E03_00690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP8S17E03_00730	COG1063	alcohol dehydrogenase
WP8S17E03_00760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S17E03_00850	COG1609	Transcriptional regulator
WP8S17E03_00890	COG1580	Controls the rotational direction of flagella during chemotaxis
WP8S17E03_00900	COG3161	chorismate lyase activity
WP8S17E03_00910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP8S17E03_00920	COG2937	Belongs to the GPAT DAPAT family
WP8S17E03_00930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S17E03_00960	COG0534	Mate efflux family protein
WP8S17E03_00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP8S17E03_00980	COG2205	protein histidine kinase activity
WP8S17E03_00990	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_01010	COG1045	serine acetyltransferase
WP8S17E03_01030	COG3074	FtsZ-dependent cytokinesis
WP8S17E03_01040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP8S17E03_01050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S17E03_01050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S17E03_01060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP8S17E03_01070	COG1609	Transcriptional regulator
WP8S17E03_01080	COG3250	beta-galactosidase activity
WP8S17E03_01090	COG2731	YhcH YjgK YiaL family protein
WP8S17E03_01100	COG0531	amino acid
WP8S17E03_01110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S17E03_01120	COG0531	amino acid
WP8S17E03_01130	COG0531	amino acid
WP8S17E03_01140	COG0385	Bile acid
WP8S17E03_01150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP8S17E03_01200	COG0583	DNA-binding transcription factor activity
WP8S17E03_01250	COG0210	DNA helicase
WP8S17E03_01320	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_01340	COG2962	Rard protein
WP8S17E03_01360	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_01370	COG1396	sequence-specific DNA binding
WP8S17E03_01400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S17E03_01400	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S17E03_01420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S17E03_01460	COG1322	Protein conserved in bacteria
WP8S17E03_01470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S17E03_01480	COG0569	domain protein
WP8S17E03_01490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S17E03_01490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S17E03_01500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP8S17E03_01510	COG0242	peptide deformylase activity
WP8S17E03_01530	COG0758	DNA mediated transformation
WP8S17E03_01540	COG2922	Belongs to the Smg family
WP8S17E03_01550	COG0551	DNA topoisomerase type I activity
WP8S17E03_01560	COG0009	L-threonylcarbamoyladenylate synthase
WP8S17E03_01570	COG0408	coproporphyrinogen oxidase activity
WP8S17E03_01580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP8S17E03_01590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP8S17E03_01610	COG3078	GTPase activator activity
WP8S17E03_01640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8S17E03_01660	COG3852	Histidine kinase
WP8S17E03_01680	COG0174	glutamine synthetase
WP8S17E03_01700	COG1295	ribonuclease BN
WP8S17E03_01710	COG1490	D-aminoacyl-tRNA deacylase activity
WP8S17E03_01740	COG0456	acetyltransferase
WP8S17E03_01760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP8S17E03_01770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S17E03_01780	COG2610	gluconate transmembrane transporter activity
WP8S17E03_01790	COG3265	gluconokinase activity
WP8S17E03_01800	COG0129	dihydroxy-acid dehydratase activity
WP8S17E03_01810	COG0800	Aldolase
WP8S17E03_01840	COG1609	Transcriptional regulator
WP8S17E03_01860	COG4942	peptidase
WP8S17E03_01870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP8S17E03_01880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S17E03_01890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP8S17E03_01900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP8S17E03_01910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP8S17E03_01910	COG0316	Belongs to the HesB IscA family
WP8S17E03_01920	COG1040	competence protein
WP8S17E03_01930	COG0596	Alpha beta hydrolase
WP8S17E03_01960	COG2183	response to ionizing radiation
WP8S17E03_01970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S17E03_01980	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_01990	COG2205	protein histidine kinase activity
WP8S17E03_02010	COG0051	transcription antitermination factor activity, RNA binding
WP8S17E03_02020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP8S17E03_02030	COG0088	Forms part of the polypeptide exit tunnel
WP8S17E03_02040	COG0089	rRNA binding
WP8S17E03_02050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP8S17E03_02060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP8S17E03_02070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP8S17E03_02080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP8S17E03_02090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP8S17E03_02100	COG0255	Belongs to the universal ribosomal protein uL29 family
WP8S17E03_02110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP8S17E03_02120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP8S17E03_02130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP8S17E03_02140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP8S17E03_02150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP8S17E03_02160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP8S17E03_02170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP8S17E03_02180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP8S17E03_02190	COG0200	Binds to the 23S rRNA
WP8S17E03_02200	COG0201	protein transport
WP8S17E03_02210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP8S17E03_02220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP8S17E03_02230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP8S17E03_02240	COG0202	RNA polymerase activity
WP8S17E03_02250	COG0203	ribosomal protein L17
WP8S17E03_02290	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8S17E03_02300	COG0583	DNA-binding transcription factor activity
WP8S17E03_02310	COG4221	oxidoreductase activity
WP8S17E03_02340	COG1770	oligopeptidase
WP8S17E03_02350	COG2358	TRAP transporter, solute receptor (TAXI family
WP8S17E03_02380	COG3714	YhhN family
WP8S17E03_02410	COG0583	DNA-binding transcription factor activity
WP8S17E03_02430	COG1301	dicarboxylic acid transport
WP8S17E03_02450	COG2095	MarC family integral membrane protein
WP8S17E03_02470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S17E03_02490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S17E03_02510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S17E03_02560	COG0742	ribosomal rna small subunit methyltransferase
WP8S17E03_02570	COG0552	protein localization to endoplasmic reticulum
WP8S17E03_02580	COG2884	Cell division ATP-binding protein ftsE
WP8S17E03_02590	COG2177	Part of the ABC transporter FtsEX involved in
WP8S17E03_02610	COG0288	reversible hydration of carbon dioxide
WP8S17E03_02620	COG2188	Transcriptional regulator
WP8S17E03_02630	COG1228	amidohydrolase
WP8S17E03_02640	COG0010	Belongs to the arginase family
WP8S17E03_02650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP8S17E03_02660	COG2986	histidine ammonia-lyase
WP8S17E03_02670	COG0387	Pfam Sodium calcium exchanger
WP8S17E03_02680	COG2200	EAL domain
WP8S17E03_02730	COG3335	DDE superfamily endonuclease
WP8S17E03_02780	COG1077	Cell shape determining protein MreB Mrl
WP8S17E03_02790	COG1792	Involved in formation and maintenance of cell shape
WP8S17E03_02800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP8S17E03_02810	COG0424	maF-like protein
WP8S17E03_02820	COG1530	ribonuclease E activity
WP8S17E03_02830	COG3164	Protein of unknown function
WP8S17E03_02840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S17E03_02850	COG0312	modulator of DNA gyrase
WP8S17E03_02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_02890	COG1263	PTS System
WP8S17E03_02900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WP8S17E03_02930	COG0477	Major facilitator Superfamily
WP8S17E03_02950	COG2321	neutral zinc metallopeptidase
WP8S17E03_03020	COG0189	ligase activity
WP8S17E03_03030	COG0642	Histidine kinase
WP8S17E03_03040	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_03070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP8S17E03_03090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S17E03_03110	COG2022	thiamine diphosphate biosynthetic process
WP8S17E03_03120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S17E03_03140	COG0110	maltose O-acetyltransferase activity
WP8S17E03_03160	COG2199	diguanylate cyclase activity
WP8S17E03_03160	COG2203	Gaf domain
WP8S17E03_03170	COG3932	Exopolysaccharide synthesis, ExoD
WP8S17E03_03210	COG1733	regulation of RNA biosynthetic process
WP8S17E03_03270	COG1494	fructose-1,6-bisphosphatase
WP8S17E03_03290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP8S17E03_03300	COG5007	Belongs to the BolA IbaG family
WP8S17E03_03320	COG2854	intermembrane phospholipid transfer
WP8S17E03_03330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S17E03_03340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP8S17E03_03350	COG1127	ABC transporter
WP8S17E03_03360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP8S17E03_03360	COG0517	IMP dehydrogenase activity
WP8S17E03_03370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP8S17E03_03390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP8S17E03_03400	COG1137	ATPase activity
WP8S17E03_03410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP8S17E03_03430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_03440	COG1660	Displays ATPase and GTPase activities
WP8S17E03_03450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_03490	COG3964	amidohydrolase
WP8S17E03_03550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S17E03_03560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S17E03_03580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP8S17E03_03590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP8S17E03_03600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP8S17E03_03610	COG0723	plastoquinol--plastocyanin reductase activity
WP8S17E03_03620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP8S17E03_03630	COG2857	Cytochrome c1
WP8S17E03_03640	COG0625	glutathione transferase activity
WP8S17E03_03650	COG2969	positive regulation of protein catabolic process
WP8S17E03_03660	COG2823	Periplasmic or secreted lipoprotein
WP8S17E03_03670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S17E03_03680	COG0792	nuclease activity
WP8S17E03_03690	COG3107	peptidoglycan biosynthetic process
WP8S17E03_03700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP8S17E03_03710	COG2001	Belongs to the MraZ family
WP8S17E03_03720	COG0275	rRNA processing
WP8S17E03_03730	COG3116	cell division
WP8S17E03_03740	COG0768	penicillin binding
WP8S17E03_03750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP8S17E03_03760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP8S17E03_03770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S17E03_03780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP8S17E03_03790	COG0772	Belongs to the SEDS family
WP8S17E03_03800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP8S17E03_03810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S17E03_03820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP8S17E03_03830	COG0849	cell division
WP8S17E03_03840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP8S17E03_03850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP8S17E03_03870	COG0653	protein targeting
WP8S17E03_03890	COG0494	nUDIX hydrolase
WP8S17E03_03900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP8S17E03_03910	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP8S17E03_03930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WP8S17E03_03940	COG1459	type II secretion system
WP8S17E03_03950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S17E03_03990	COG2186	Transcriptional regulator
WP8S17E03_04000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP8S17E03_04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S17E03_04020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S17E03_04040	COG0840	transmembrane signaling receptor activity
WP8S17E03_04050	COG0840	transmembrane signaling receptor activity
WP8S17E03_04060	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S17E03_04070	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP8S17E03_04080	COG2200	EAL domain
WP8S17E03_04100	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_04120	COG0523	cobalamin synthesis protein
WP8S17E03_04130	COG0477	Major facilitator Superfamily
WP8S17E03_04160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP8S17E03_04170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP8S17E03_04220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP8S17E03_04240	COG1546	Belongs to the CinA family
WP8S17E03_04250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP8S17E03_04260	COG2137	regulation of response to DNA damage stimulus
WP8S17E03_04270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8S17E03_04280	COG0527	aspartate kinase activity
WP8S17E03_04290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP8S17E03_04300	COG1686	Belongs to the peptidase S11 family
WP8S17E03_04310	COG0586	Pfam SNARE associated Golgi protein
WP8S17E03_04320	COG1253	flavin adenine dinucleotide binding
WP8S17E03_04330	COG0525	valine-tRNA ligase activity
WP8S17E03_04340	COG2927	DNA polymerase III (CHI subunit)
WP8S17E03_04350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S17E03_04360	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S17E03_04370	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S17E03_04400	COG0004	ammonium transporteR
WP8S17E03_04410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S17E03_04450	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8S17E03_04460	COG0084	hydrolase, TatD family'
WP8S17E03_04470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S17E03_04490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP8S17E03_04500	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP8S17E03_04510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP8S17E03_04520	COG0813	purine-nucleoside phosphorylase activity
WP8S17E03_04530	COG3447	MASE1 domain protein
WP8S17E03_04530	COG5001	Diguanylate cyclase
WP8S17E03_04530	COG5002	protein histidine kinase activity
WP8S17E03_04550	COG0560	Phosphoserine phosphatase
WP8S17E03_04580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP8S17E03_04600	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP8S17E03_04610	COG0776	regulation of translation
WP8S17E03_04640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S17E03_04650	COG0735	belongs to the Fur family
WP8S17E03_04690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP8S17E03_04700	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_04710	COG3022	response to hydroperoxide
WP8S17E03_04720	COG2805	Type II/IV secretion system protein
WP8S17E03_04740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP8S17E03_04750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP8S17E03_04760	COG0762	integral membrane protein
WP8S17E03_04770	COG1872	DUF167
WP8S17E03_04810	COG3112	Uncharacterised protein family (UPF0231)
WP8S17E03_04820	COG3835	regulator
WP8S17E03_04830	COG2610	gluconate transmembrane transporter activity
WP8S17E03_04840	COG1929	Belongs to the glycerate kinase type-1 family
WP8S17E03_04870	COG0583	DNA-binding transcription factor activity
WP8S17E03_04880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S17E03_04910	COG0347	Belongs to the P(II) protein family
WP8S17E03_04940	COG3842	ATPase activity
WP8S17E03_04950	COG2837	iron assimilation
WP8S17E03_04960	COG1438	arginine binding
WP8S17E03_04970	COG1126	abc transporter atp-binding protein
WP8S17E03_04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_04990	COG4215	(ABC) transporter
WP8S17E03_05000	COG4160	amino acid transport
WP8S17E03_05010	COG0039	L-malate dehydrogenase activity
WP8S17E03_05020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP8S17E03_05030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S17E03_05030	COG1017	nitric oxide dioxygenase activity
WP8S17E03_05050	COG4536	flavin adenine dinucleotide binding
WP8S17E03_05060	COG4137	Cytochrome C assembly protein
WP8S17E03_05070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP8S17E03_05080	COG0228	four-way junction DNA binding
WP8S17E03_05090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP8S17E03_05100	COG0336	Belongs to the RNA methyltransferase TrmD family
WP8S17E03_05110	COG0335	large ribosomal subunit rRNA binding
WP8S17E03_05150	COG1051	belongs to the nudix hydrolase family
WP8S17E03_05170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP8S17E03_05180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP8S17E03_05190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S17E03_05210	COG0583	DNA-binding transcription factor activity
WP8S17E03_05220	COG0640	Transcriptional regulator
WP8S17E03_05230	COG0268	Binds directly to 16S ribosomal RNA
WP8S17E03_05240	COG0728	peptidoglycan biosynthetic process
WP8S17E03_05250	COG0196	riboflavin kinase activity
WP8S17E03_05260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP8S17E03_05270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP8S17E03_05280	COG1047	Peptidyl-prolyl cis-trans
WP8S17E03_05290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP8S17E03_05370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S17E03_05370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP8S17E03_05400	COG1854	S-ribosylhomocysteine lyase activity
WP8S17E03_05410	COG3706	GGDEF domain
WP8S17E03_05420	COG0557	exoribonuclease II activity
WP8S17E03_05430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S17E03_05450	COG2153	protein acetylation
WP8S17E03_05470	COG1914	H( )-stimulated, divalent metal cation uptake system
WP8S17E03_05490	COG0360	Binds together with S18 to 16S ribosomal RNA
WP8S17E03_05500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP8S17E03_05510	COG0359	binds to the 23S rRNA
WP8S17E03_05590	COG1238	metal cluster binding
WP8S17E03_05600	COG0612	Peptidase, M16
WP8S17E03_05610	COG2918	glutathione biosynthetic process
WP8S17E03_05620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S17E03_05630	COG1027	Aspartate ammonia-lyase
WP8S17E03_05640	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP8S17E03_05650	COG0534	Mate efflux family protein
WP8S17E03_05660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP8S17E03_05670	COG0459	protein refolding
WP8S17E03_05710	COG0564	pseudouridine synthase activity
WP8S17E03_05720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8S17E03_05730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP8S17E03_05750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP8S17E03_05760	COG4208	sulfate ABC transporter
WP8S17E03_05770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP8S17E03_05780	COG0583	DNA-binding transcription factor activity
WP8S17E03_05790	COG3397	chitin binding
WP8S17E03_05850	COG1328	CTP reductase activity
WP8S17E03_05860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S17E03_05890	COG1448	Aminotransferase
WP8S17E03_05900	COG2194	sulfuric ester hydrolase activity
WP8S17E03_05940	COG1215	transferase activity, transferring glycosyl groups
WP8S17E03_05960	COG0457	Tetratricopeptide repeat
WP8S17E03_05960	COG3118	belongs to the thioredoxin family
WP8S17E03_06030	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_06040	COG0840	transmembrane signaling receptor activity
WP8S17E03_06060	COG4166	transmembrane transport
WP8S17E03_06090	COG1024	Enoyl-CoA hydratase
WP8S17E03_06120	COG4221	oxidoreductase activity
WP8S17E03_06130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S17E03_06140	COG0442	prolyl-tRNA aminoacylation
WP8S17E03_06150	COG0840	transmembrane signaling receptor activity
WP8S17E03_06160	COG0632	four-way junction helicase activity
WP8S17E03_06170	COG2255	four-way junction helicase activity
WP8S17E03_06180	COG1271	oxidase subunit
WP8S17E03_06190	COG1294	oxidase, subunit
WP8S17E03_06200	COG4890	Cyd operon protein YbgT
WP8S17E03_06210	COG3790	cyd operon protein YbgE
WP8S17E03_06220	COG0824	Thioesterase
WP8S17E03_06230	COG0811	peptide transport
WP8S17E03_06260	COG0823	Involved in the tonB-independent uptake of proteins
WP8S17E03_06270	COG2885	chlorophyll binding
WP8S17E03_06280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP8S17E03_06290	COG0840	transmembrane signaling receptor activity
WP8S17E03_06300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP8S17E03_06320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S17E03_06330	COG1640	4-alpha-glucanotransferase
WP8S17E03_06340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP8S17E03_06400	COG2130	NADP-dependent
WP8S17E03_06410	COG1846	Transcriptional regulator
WP8S17E03_06470	COG0561	phosphatase activity
WP8S17E03_06500	COG0733	neurotransmitter:sodium symporter activity
WP8S17E03_06510	COG0733	neurotransmitter:sodium symporter activity
WP8S17E03_06530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S17E03_06560	COG1794	racemase activity, acting on amino acids and derivatives
WP8S17E03_06570	COG1794	racemase activity, acting on amino acids and derivatives
WP8S17E03_06600	COG1022	Amp-dependent synthetase and ligase
WP8S17E03_06620	COG0456	acetyltransferase
WP8S17E03_06650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP8S17E03_06660	COG5001	Diguanylate cyclase
WP8S17E03_06660	COG5002	protein histidine kinase activity
WP8S17E03_06700	COG0456	acetyltransferase
WP8S17E03_06720	COG0456	acetyltransferase
WP8S17E03_06730	COG1902	pentaerythritol trinitrate reductase activity
WP8S17E03_06750	COG2852	Protein conserved in bacteria
WP8S17E03_06770	COG2957	Belongs to the agmatine deiminase family
WP8S17E03_06780	COG0154	amidase activity
WP8S17E03_06850	COG1917	Cupin 2, conserved barrel domain protein
WP8S17E03_06850	COG2207	Transcriptional regulator
WP8S17E03_06870	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_06880	COG2199	diguanylate cyclase activity
WP8S17E03_06880	COG2203	Gaf domain
WP8S17E03_06950	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP8S17E03_06970	COG1136	(ABC) transporter
WP8S17E03_06970	COG0577	efflux transmembrane transporter activity
WP8S17E03_06980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_06990	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_07000	COG2205	protein histidine kinase activity
WP8S17E03_07080	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_07090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP8S17E03_07100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S17E03_07120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_07180	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_07190	COG3104	oligopeptide transport
WP8S17E03_07200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP8S17E03_07210	COG1555	photosystem II stabilization
WP8S17E03_07230	COG2350	Protein conserved in bacteria
WP8S17E03_07240	COG2917	probably involved in intracellular septation
WP8S17E03_07250	COG0076	glutamate decarboxylase activity
WP8S17E03_07260	COG1272	protein, Hemolysin III
WP8S17E03_07270	COG0569	domain protein
WP8S17E03_07270	COG2985	domain, Protein
WP8S17E03_07300	COG0477	Major facilitator Superfamily
WP8S17E03_07310	COG0583	DNA-binding transcription factor activity
WP8S17E03_07320	COG3227	Zinc metalloprotease (Elastase)
WP8S17E03_07330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S17E03_07340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S17E03_07360	COG2731	YhcH YjgK YiaL family protein
WP8S17E03_07380	COG0668	transmembrane transport
WP8S17E03_07400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S17E03_07540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP8S17E03_07560	COG0488	(ABC) transporter
WP8S17E03_07570	COG0517	IMP dehydrogenase activity
WP8S17E03_07570	COG0516	GMP reductase activity
WP8S17E03_07590	COG0835	chemotaxis
WP8S17E03_07590	COG0784	Response regulator, receiver
WP8S17E03_07600	COG2755	lipolytic protein G-D-S-L family
WP8S17E03_07610	COG4181	ATPase activity
WP8S17E03_07620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP8S17E03_07630	COG1090	epimerase
WP8S17E03_07640	COG2200	EAL domain
WP8S17E03_07650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S17E03_07660	COG4935	Belongs to the peptidase S8 family
WP8S17E03_07660	COG2234	aminopeptidase activity
WP8S17E03_07670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP8S17E03_07680	COG3171	Protein conserved in bacteria
WP8S17E03_07690	COG2066	Belongs to the glutaminase family
WP8S17E03_07700	COG2897	thiosulfate sulfurtransferase activity
WP8S17E03_07720	COG1132	(ABC) transporter
WP8S17E03_07760	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP8S17E03_07770	COG3300	MHYT domain
WP8S17E03_07770	COG5001	Diguanylate cyclase
WP8S17E03_07810	COG4628	conserved protein (DUF2132)
WP8S17E03_07820	COG0688	phosphatidylethanolamine metabolic process
WP8S17E03_07830	COG1162	GTPase activity
WP8S17E03_07840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP8S17E03_07850	COG1278	Cold shock
WP8S17E03_07870	COG0840	transmembrane signaling receptor activity
WP8S17E03_07880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S17E03_07910	COG3335	DDE superfamily endonuclease
WP8S17E03_07950	COG0675	Transposase, IS605 OrfB family
WP8S17E03_07990	COG0848	biopolymer transport protein
WP8S17E03_08000	COG0811	peptide transport
WP8S17E03_08010	COG0811	peptide transport
WP8S17E03_08030	COG4206	TonB-dependent receptor
WP8S17E03_08040	COG4174	ABC transporter (Permease)
WP8S17E03_08050	COG4239	(ABC) transporter, permease
WP8S17E03_08070	COG0444	Belongs to the ABC transporter superfamily
WP8S17E03_08080	COG4608	Belongs to the ABC transporter superfamily
WP8S17E03_08100	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S17E03_08120	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP8S17E03_08160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP8S17E03_08220	COG0243	molybdopterin cofactor binding
WP8S17E03_08230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S17E03_08230	COG1648	precorrin-2 dehydrogenase activity
WP8S17E03_08250	COG1116	anion transmembrane transporter activity
WP8S17E03_08250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP8S17E03_08260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP8S17E03_08270	COG1116	anion transmembrane transporter activity
WP8S17E03_08280	COG2146	nitrite reductase [NAD(P)H] activity
WP8S17E03_08280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S17E03_08290	COG2146	nitrite reductase [NAD(P)H] activity
WP8S17E03_08290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S17E03_08300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S17E03_08310	COG2313	pseudouridylate synthase activity
WP8S17E03_08350	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S17E03_08380	COG2966	Psort location CytoplasmicMembrane, score
WP8S17E03_08390	COG3610	response to peptide
WP8S17E03_08410	COG4175	Glycine betaine
WP8S17E03_08420	COG4176	ABC-type proline glycine betaine transport system permease component
WP8S17E03_08430	COG2113	Glycine betaine
WP8S17E03_08440	COG0175	sulfate reduction
WP8S17E03_08450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S17E03_08460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP8S17E03_08480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP8S17E03_08490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP8S17E03_08510	COG0786	glutamate:sodium symporter activity
WP8S17E03_08520	COG0252	asparaginase activity
WP8S17E03_08530	COG3139	Protein of unknown function (DUF1315)
WP8S17E03_08570	COG0616	signal peptide processing
WP8S17E03_08580	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S17E03_08580	COG1902	pentaerythritol trinitrate reductase activity
WP8S17E03_08590	COG0778	Nitroreductase
WP8S17E03_08610	COG0110	maltose O-acetyltransferase activity
WP8S17E03_08620	COG2264	protein methyltransferase activity
WP8S17E03_08630	COG0604	alcohol dehydrogenase
WP8S17E03_08640	COG0583	DNA-binding transcription factor activity
WP8S17E03_08650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_08650	COG2190	(PTS) system
WP8S17E03_08650	COG1263	PTS System
WP8S17E03_08660	COG4145	pantothenate transmembrane transporter activity
WP8S17E03_08670	COG3924	membrane
WP8S17E03_08680	COG0439	Biotin carboxylase
WP8S17E03_08690	COG0511	ligase activity, forming carbon-carbon bonds
WP8S17E03_08700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP8S17E03_08710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S17E03_08740	COG3381	protein complex oligomerization
WP8S17E03_08760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP8S17E03_08780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP8S17E03_08790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S17E03_08790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S17E03_08820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP8S17E03_08830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S17E03_08840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP8S17E03_08850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP8S17E03_08860	COG4172	Belongs to the ABC transporter superfamily
WP8S17E03_08900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP8S17E03_08910	COG0142	geranyltranstransferase activity
WP8S17E03_08920	COG1722	exodeoxyribonuclease VII activity
WP8S17E03_08930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S17E03_08940	COG1360	Flagellar Motor Protein
WP8S17E03_08970	COG1534	Rna-binding protein
WP8S17E03_08980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP8S17E03_09000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP8S17E03_09010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP8S17E03_09020	COG0149	triose-phosphate isomerase activity
WP8S17E03_09030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP8S17E03_09040	COG0779	Required for maturation of 30S ribosomal subunits
WP8S17E03_09050	COG0195	Participates in both transcription termination and antitermination
WP8S17E03_09060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP8S17E03_09070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP8S17E03_09080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP8S17E03_09090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP8S17E03_09100	COG1185	polyribonucleotide nucleotidyltransferase activity
WP8S17E03_09110	COG2211	Major facilitator Superfamily
WP8S17E03_09120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S17E03_09130	COG1422	Protein of unknown function (DUF1090)
WP8S17E03_09140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S17E03_09190	COG0312	modulator of DNA gyrase
WP8S17E03_09210	COG0312	modulator of DNA gyrase
WP8S17E03_09230	COG4974	Belongs to the 'phage' integrase family
WP8S17E03_09240	COG1970	mechanosensitive ion channel activity
WP8S17E03_09270	COG0789	Transcriptional regulator
WP8S17E03_09300	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S17E03_09320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP8S17E03_09340	COG0321	lipoyl(octanoyl) transferase activity
WP8S17E03_09350	COG2921	Belongs to the UPF0250 family
WP8S17E03_09360	COG1686	Belongs to the peptidase S11 family
WP8S17E03_09370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP8S17E03_09380	COG2951	lytic endotransglycosylase activity
WP8S17E03_09390	COG0772	Belongs to the SEDS family
WP8S17E03_09400	COG0768	penicillin binding
WP8S17E03_09410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP8S17E03_09420	COG0799	negative regulation of ribosome biogenesis
WP8S17E03_09430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP8S17E03_09470	COG0495	leucyl-tRNA aminoacylation
WP8S17E03_09480	COG2888	peptidyl-tyrosine sulfation
WP8S17E03_09490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP8S17E03_09500	COG4535	Mg2 and Co2 transporter CorC
WP8S17E03_09510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP8S17E03_09520	COG1702	phosphate starvation-inducible protein PhoH
WP8S17E03_09530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S17E03_09540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S17E03_09550	COG1335	isochorismatase
WP8S17E03_09560	COG1278	Cold shock
WP8S17E03_09590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S17E03_09600	COG2199	diguanylate cyclase activity
WP8S17E03_09620	COG2199	diguanylate cyclase activity
WP8S17E03_09640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S17E03_09670	COG1464	Belongs to the NlpA lipoprotein family
WP8S17E03_09680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP8S17E03_09690	COG2011	ABC-type metal ion transport system permease component
WP8S17E03_09700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP8S17E03_09720	COG0516	GMP reductase activity
WP8S17E03_09730	COG4067	protein conserved in archaea
WP8S17E03_09730	COG0189	ligase activity
WP8S17E03_09770	COG0300	oxidoreductase activity
WP8S17E03_09810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S17E03_09820	COG3214	Protein conserved in bacteria
WP8S17E03_09850	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S17E03_09860	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S17E03_09870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP8S17E03_09880	COG1053	succinate dehydrogenase
WP8S17E03_09900	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S17E03_09910	COG1511	domain protein
WP8S17E03_09910	COG3264	Mechanosensitive ion channel
WP8S17E03_09930	COG0739	heme binding
WP8S17E03_09960	COG0583	DNA-binding transcription factor activity
WP8S17E03_09990	COG0583	DNA-binding transcription factor activity
WP8S17E03_10000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP8S17E03_10060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP8S17E03_10070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP8S17E03_10090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP8S17E03_10100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP8S17E03_10110	COG0546	phosphoglycolate phosphatase activity
WP8S17E03_10120	COG0180	Tryptophanyl-tRNA synthetase
WP8S17E03_10150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP8S17E03_10170	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_10190	COG3039	Transposase
WP8S17E03_10200	COG2801	Transposase and inactivated derivatives
WP8S17E03_10210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S17E03_10260	COG0471	metal ion transport
WP8S17E03_10260	COG0490	domain, Protein
WP8S17E03_10270	COG0012	GTP binding
WP8S17E03_10280	COG0193	aminoacyl-tRNA hydrolase activity
WP8S17E03_10290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP8S17E03_10300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP8S17E03_10310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP8S17E03_10320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP8S17E03_10330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP8S17E03_10340	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S17E03_10360	COG2912	Transglutaminase-like superfamily
WP8S17E03_10370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP8S17E03_10380	COG1301	dicarboxylic acid transport
WP8S17E03_10400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP8S17E03_10430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8S17E03_10440	COG1115	amino acid carrier protein
WP8S17E03_10480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP8S17E03_10500	COG0189	ligase activity
WP8S17E03_10510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP8S17E03_10530	COG3091	SprT-like family
WP8S17E03_10550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP8S17E03_10560	COG3415	Transposase
WP8S17E03_10560	COG2801	Transposase and inactivated derivatives
WP8S17E03_10580	COG2801	Transposase and inactivated derivatives
WP8S17E03_10620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP8S17E03_10640	COG0739	heme binding
WP8S17E03_10650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S17E03_10660	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WP8S17E03_10660	COG3408	Glycogen debranching enzyme
WP8S17E03_10680	COG1881	PFAM PEBP family protein
WP8S17E03_10700	COG0583	DNA-binding transcription factor activity
WP8S17E03_10720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8S17E03_10740	COG0583	DNA-binding transcription factor activity
WP8S17E03_10750	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S17E03_10760	COG0616	signal peptide processing
WP8S17E03_10770	COG3724	N-succinylarginine dihydrolase activity
WP8S17E03_10810	COG0840	transmembrane signaling receptor activity
WP8S17E03_10840	COG2971	BadF BadG BcrA BcrD
WP8S17E03_10860	COG4608	Belongs to the ABC transporter superfamily
WP8S17E03_10870	COG0444	Belongs to the ABC transporter superfamily
WP8S17E03_10880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S17E03_10910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S17E03_10930	COG0640	Transcriptional regulator
WP8S17E03_10940	COG0798	PFAM Bile acid sodium symporter
WP8S17E03_10950	COG1393	Belongs to the ArsC family
WP8S17E03_10970	COG1677	Flagellar hook-basal body complex protein FliE
WP8S17E03_10990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP8S17E03_11110	COG1684	flagellar biosynthetic protein fliR
WP8S17E03_11130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP8S17E03_11180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP8S17E03_11190	COG0643	Histidine kinase
WP8S17E03_11190	COG0784	Response regulator, receiver
WP8S17E03_11190	COG2198	Histidine kinase
WP8S17E03_11210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S17E03_11220	COG1360	Flagellar Motor Protein
WP8S17E03_11230	COG1192	Involved in chromosome partitioning
WP8S17E03_11250	COG0835	chemotaxis
WP8S17E03_11280	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S17E03_11290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S17E03_11300	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S17E03_11310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP8S17E03_11320	COG1138	Cytochrome C-type biogenesis protein
WP8S17E03_11330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S17E03_11350	COG0457	Tetratricopeptide repeat
WP8S17E03_11380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP8S17E03_11390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S17E03_11390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S17E03_11420	COG0259	pyridoxamine-phosphate oxidase activity
WP8S17E03_11480	COG3153	acetyltransferase
WP8S17E03_11510	COG0800	Aldolase
WP8S17E03_11710	COG0640	Transcriptional regulator
WP8S17E03_11730	COG4373	Mu-like prophage FluMu protein gp28
WP8S17E03_11740	COG4383	Mu-like prophage protein gp29
WP8S17E03_11780	COG2194	sulfuric ester hydrolase activity
WP8S17E03_11790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8S17E03_11810	COG4388	Caudovirus prohead serine protease
WP8S17E03_11820	COG4397	Mu-like prophage major head subunit gpT
WP8S17E03_11950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP8S17E03_11960	COG2867	negative regulation of translational initiation
WP8S17E03_11980	COG0702	epimerase
WP8S17E03_11990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S17E03_12000	COG1454	alcohol dehydrogenase
WP8S17E03_12020	COG0564	pseudouridine synthase activity
WP8S17E03_12030	COG1957	nucleoside hydrolase
WP8S17E03_12080	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_12100	COG3263	regulation of cellular component size
WP8S17E03_12120	COG1876	peptidase activity
WP8S17E03_12130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8S17E03_12140	COG1393	Belongs to the ArsC family
WP8S17E03_12160	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S17E03_12170	COG1473	amidohydrolase
WP8S17E03_12190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S17E03_12200	COG0017	Asparaginyl-tRNA synthetase
WP8S17E03_12240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S17E03_12250	COG0156	8-amino-7-oxononanoate synthase activity
WP8S17E03_12260	COG1073	alpha beta
WP8S17E03_12260	COG2226	methyltransferase
WP8S17E03_12270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP8S17E03_12280	COG0501	Belongs to the peptidase M48B family
WP8S17E03_12290	COG3217	Mosc domain protein beta barrel domain protein
WP8S17E03_12290	COG0633	Ferredoxin
WP8S17E03_12290	COG3217	Mosc domain protein beta barrel domain protein
WP8S17E03_12290	COG0633	Ferredoxin
WP8S17E03_12310	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP8S17E03_12310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP8S17E03_12310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP8S17E03_12310	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP8S17E03_12320	COG2841	Protein conserved in bacteria
WP8S17E03_12340	COG0534	Mate efflux family protein
WP8S17E03_12390	COG1454	alcohol dehydrogenase
WP8S17E03_12410	COG1309	transcriptional regulator
WP8S17E03_12440	COG0791	NLP P60 protein
WP8S17E03_12450	COG0583	DNA-binding transcription factor activity
WP8S17E03_12490	COG0500	methyltransferase
WP8S17E03_12500	COG4106	trans-aconitate 2-methyltransferase activity
WP8S17E03_12510	COG1801	Protein of unknown function DUF72
WP8S17E03_12520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP8S17E03_12530	COG0217	transcriptional regulatory protein
WP8S17E03_12540	COG2194	sulfuric ester hydrolase activity
WP8S17E03_12550	COG1846	Transcriptional regulator
WP8S17E03_12550	COG1940	carbohydrate kinase activity
WP8S17E03_12560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S17E03_12570	COG0363	glucosamine-6-phosphate deaminase activity
WP8S17E03_12580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_12580	COG2190	(PTS) system
WP8S17E03_12580	COG1263	PTS System
WP8S17E03_12600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S17E03_12610	COG0735	belongs to the Fur family
WP8S17E03_12630	COG0716	FMN binding
WP8S17E03_12660	COG0596	Alpha beta hydrolase
WP8S17E03_12670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP8S17E03_12680	COG0033	Phosphoglucomutase
WP8S17E03_12700	COG1846	Transcriptional regulator
WP8S17E03_12710	COG2951	lytic endotransglycosylase activity
WP8S17E03_12720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP8S17E03_12730	COG4136	ATPase activity
WP8S17E03_12750	COG4134	Bacterial extracellular solute-binding protein
WP8S17E03_12760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S17E03_12770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8S17E03_12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S17E03_12810	COG3039	Transposase
WP8S17E03_12820	COG0729	surface antigen
WP8S17E03_12830	COG2911	Protein conserved in bacteria
WP8S17E03_12850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP8S17E03_12870	COG0741	lytic transglycosylase activity
WP8S17E03_12900	COG1607	acyl-coa hydrolase
WP8S17E03_12930	COG1388	LysM domain
WP8S17E03_12930	COG0741	lytic transglycosylase activity
WP8S17E03_12940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S17E03_12950	COG2226	methyltransferase
WP8S17E03_12960	COG0328	RNA-DNA hybrid ribonuclease activity
WP8S17E03_12970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S17E03_12990	COG3437	response regulator, receiver
WP8S17E03_12990	COG0784	Response regulator, receiver
WP8S17E03_13000	COG0784	Response regulator, receiver
WP8S17E03_13000	COG3437	response regulator, receiver
WP8S17E03_13010	COG1960	acyl-CoA dehydrogenase activity
WP8S17E03_13020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S17E03_13030	COG0121	glutamine amidotransferase
WP8S17E03_13050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WP8S17E03_13100	COG2197	response regulator
WP8S17E03_13110	COG3850	Histidine kinase
WP8S17E03_13120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP8S17E03_13130	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S17E03_13130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S17E03_13150	COG0243	molybdopterin cofactor binding
WP8S17E03_13160	COG0437	4 iron, 4 sulfur cluster binding
WP8S17E03_13170	COG0348	domain, Protein
WP8S17E03_13190	COG3005	denitrification pathway
WP8S17E03_13200	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S17E03_13210	COG0315	cyclic pyranopterin monophosphate synthase activity
WP8S17E03_13220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP8S17E03_13230	COG0314	molybdopterin synthase activity
WP8S17E03_13260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP8S17E03_13270	COG2267	carboxylic ester hydrolase activity
WP8S17E03_13280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S17E03_13300	COG0302	gtp cyclohydrolase
WP8S17E03_13310	COG0840	transmembrane signaling receptor activity
WP8S17E03_13320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP8S17E03_13340	COG0583	DNA-binding transcription factor activity
WP8S17E03_13370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP8S17E03_13400	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S17E03_13410	COG1166	arginine decarboxylase activity
WP8S17E03_13460	COG1061	Type III restriction enzyme res subunit
WP8S17E03_13500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP8S17E03_13510	COG1187	pseudouridine synthase activity
WP8S17E03_13520	COG2807	transmembrane transport
WP8S17E03_13540	COG0583	DNA-binding transcription factor activity
WP8S17E03_13580	COG2979	Protein of unknown function (DUF533)
WP8S17E03_13600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S17E03_13610	COG1271	oxidase subunit
WP8S17E03_13620	COG1294	oxidase, subunit
WP8S17E03_13640	COG2814	Major facilitator Superfamily
WP8S17E03_13650	COG0656	L-ascorbic acid biosynthetic process
WP8S17E03_13690	COG0583	DNA-binding transcription factor activity
WP8S17E03_13700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP8S17E03_13710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S17E03_13720	COG2271	Major facilitator Superfamily
WP8S17E03_13730	COG1349	DNA-binding transcription factor activity
WP8S17E03_13750	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S17E03_13760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S17E03_13770	COG1605	Chorismate mutase
WP8S17E03_13770	COG0287	Prephenate dehydrogenase
WP8S17E03_13790	COG3085	chromosome segregation
WP8S17E03_13800	COG4574	serine-type endopeptidase inhibitor activity
WP8S17E03_13840	COG1770	oligopeptidase
WP8S17E03_13850	COG4771	TonB-dependent receptor
WP8S17E03_13860	COG3083	sulfuric ester hydrolase activity
WP8S17E03_13870	COG3082	Protein of unknown function (DUF1414)
WP8S17E03_13880	COG3081	Nucleoid-associated protein
WP8S17E03_13900	COG1175	transmembrane transport
WP8S17E03_13910	COG3833	ABC-type maltose transport systems, permease component
WP8S17E03_13920	COG3842	ATPase activity
WP8S17E03_13940	COG0596	Alpha beta hydrolase
WP8S17E03_13970	COG4783	chaperone-mediated protein folding
WP8S17E03_13990	COG1393	Belongs to the ArsC family
WP8S17E03_14030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_14040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S17E03_14050	COG2431	L-lysine efflux transmembrane transporter activity
WP8S17E03_14070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_14090	COG4160	amino acid transport
WP8S17E03_14110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S17E03_14130	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S17E03_14140	COG0628	permease
WP8S17E03_14180	COG2373	Large extracellular alpha-helical protein
WP8S17E03_14190	COG4953	penicillin-binding protein 1C
WP8S17E03_14210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S17E03_14210	COG0301	tRNA thio-modification
WP8S17E03_14240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8S17E03_14250	COG1334	flagellar protein FlaG
WP8S17E03_14300	COG3039	Transposase
WP8S17E03_14320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8S17E03_14340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP8S17E03_14380	COG0346	lactoylglutathione lyase activity
WP8S17E03_14390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP8S17E03_14400	COG4660	Part of a membrane complex involved in electron transport
WP8S17E03_14410	COG4659	FMN binding
WP8S17E03_14420	COG4658	electron transport chain
WP8S17E03_14440	COG2878	Part of a membrane complex involved in electron transport
WP8S17E03_14450	COG4657	Part of a membrane complex involved in electron transport
WP8S17E03_14460	COG0675	Transposase, IS605 OrfB family
WP8S17E03_14470	COG0697	spore germination
WP8S17E03_14510	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8S17E03_14530	COG1288	antiporter activity
WP8S17E03_14540	COG0436	Aminotransferase
WP8S17E03_14560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP8S17E03_14570	COG2027	D-alanyl-D-alanine carboxypeptidase
WP8S17E03_14580	COG1061	Type III restriction enzyme res subunit
WP8S17E03_14590	COG1566	PFAM secretion protein HlyD family protein
WP8S17E03_14610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8S17E03_14610	COG3264	Mechanosensitive ion channel
WP8S17E03_14620	COG1966	Carbon starvation protein
WP8S17E03_14630	COG3279	Response regulator of the LytR AlgR family
WP8S17E03_14640	COG3275	phosphorelay sensor kinase activity
WP8S17E03_14660	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_14660	COG1454	alcohol dehydrogenase
WP8S17E03_14670	COG2095	MarC family integral membrane protein
WP8S17E03_14690	COG0601	transmembrane transport
WP8S17E03_14700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S17E03_14710	COG0444	Belongs to the ABC transporter superfamily
WP8S17E03_14730	COG0861	Integral membrane protein TerC family
WP8S17E03_14740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S17E03_14760	COG1301	dicarboxylic acid transport
WP8S17E03_14780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP8S17E03_14810	COG0537	adenosine 5'-monophosphoramidase activity
WP8S17E03_14880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S17E03_14890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S17E03_14920	COG2354	Protein conserved in bacteria
WP8S17E03_14930	COG1164	Oligoendopeptidase f
WP8S17E03_14940	COG1164	Oligoendopeptidase f
WP8S17E03_14950	COG3150	esterase
WP8S17E03_14960	COG1252	NADH dehydrogenase
WP8S17E03_14970	COG0393	Putative heavy-metal-binding
WP8S17E03_14980	COG1368	sulfuric ester hydrolase activity
WP8S17E03_15000	COG0527	aspartate kinase activity
WP8S17E03_15010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S17E03_15010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP8S17E03_15020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8S17E03_15070	COG0583	DNA-binding transcription factor activity
WP8S17E03_15080	COG1620	l-lactate permease
WP8S17E03_15090	COG0247	lactate metabolic process
WP8S17E03_15100	COG1139	Iron-sulfur cluster binding protein
WP8S17E03_15160	COG1136	(ABC) transporter
WP8S17E03_15200	COG2814	Major facilitator Superfamily
WP8S17E03_15250	COG0672	)-iron permease
WP8S17E03_15320	COG2308	Evidence 4 Homologs of previously reported genes of
WP8S17E03_15330	COG0659	secondary active sulfate transmembrane transporter activity
WP8S17E03_15340	COG3335	DDE superfamily endonuclease
WP8S17E03_15390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP8S17E03_15400	COG0326	Molecular chaperone. Has ATPase activity
WP8S17E03_15410	COG0563	adenylate kinase activity
WP8S17E03_15420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP8S17E03_15430	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP8S17E03_15440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S17E03_15450	COG0840	transmembrane signaling receptor activity
WP8S17E03_15480	COG5001	Diguanylate cyclase
WP8S17E03_15480	COG3300	MHYT domain
WP8S17E03_15530	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP8S17E03_15540	COG1535	isochorismatase
WP8S17E03_15540	COG3433	isochorismatase activity
WP8S17E03_15550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP8S17E03_15560	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S17E03_15580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP8S17E03_15610	COG1120	ATPase activity
WP8S17E03_15620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S17E03_15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S17E03_15640	COG4771	TonB-dependent receptor
WP8S17E03_15720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP8S17E03_15730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP8S17E03_15740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S17E03_15750	COG0861	Integral membrane protein TerC family
WP8S17E03_15780	COG1022	Amp-dependent synthetase and ligase
WP8S17E03_15790	COG0295	cytidine deaminase activity
WP8S17E03_15800	COG1346	cytolysis
WP8S17E03_15810	COG1380	Effector of murein hydrolase LrgA
WP8S17E03_15820	COG3345	alpha-galactosidase
WP8S17E03_15840	COG2925	Exonuclease
WP8S17E03_15860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8S17E03_15870	COG0392	lysyltransferase activity
WP8S17E03_15870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP8S17E03_15900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S17E03_15910	COG0436	Aminotransferase
WP8S17E03_15920	COG0583	DNA-binding transcription factor activity
WP8S17E03_15930	COG2160	L-arabinose isomerase activity
WP8S17E03_15950	COG1069	ribulokinase activity
WP8S17E03_15960	COG1879	ABC-type sugar transport system periplasmic component
WP8S17E03_15970	COG1129	ABC transporter
WP8S17E03_15980	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S17E03_16000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP8S17E03_16010	COG0254	rRNA binding
WP8S17E03_16040	COG1451	nucleotide metabolic process
WP8S17E03_16070	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S17E03_16090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S17E03_16090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP8S17E03_16100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8S17E03_16140	COG2009	succinate dehydrogenase
WP8S17E03_16150	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP8S17E03_16180	COG0567	Dehydrogenase, E1 component
WP8S17E03_16190	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S17E03_16200	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S17E03_16210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WP8S17E03_16220	COG2801	Transposase and inactivated derivatives
WP8S17E03_16240	COG2983	Belongs to the UPF0260 family
WP8S17E03_16250	COG1882	Formate acetyltransferase
WP8S17E03_16260	COG2116	formate transmembrane transporter activity
WP8S17E03_16270	COG1944	ATP diphosphatase activity
WP8S17E03_16290	COG2076	Multidrug Resistance protein
WP8S17E03_16300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S17E03_16310	COG1278	Cold shock
WP8S17E03_16320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP8S17E03_16330	COG0542	response to heat
WP8S17E03_16340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP8S17E03_16350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP8S17E03_16360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP8S17E03_16370	COG3134	Outer membrane lipoprotein
WP8S17E03_16380	COG3706	GGDEF domain
WP8S17E03_16390	COG0492	ferredoxin-NADP+ reductase activity
WP8S17E03_16400	COG0686	Belongs to the AlaDH PNT family
WP8S17E03_16420	COG1674	ftsk spoiiie
WP8S17E03_16420	COG0531	amino acid
WP8S17E03_16430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP8S17E03_16440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP8S17E03_16450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP8S17E03_16460	COG1286	toxin biosynthetic process
WP8S17E03_16470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP8S17E03_16480	COG2723	6-phospho-beta-galactosidase activity
WP8S17E03_16490	COG1263	PTS System
WP8S17E03_16490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_16500	COG1609	Transcriptional regulator
WP8S17E03_16520	COG4172	Belongs to the ABC transporter superfamily
WP8S17E03_16550	COG4171	peptide transport system, permease
WP8S17E03_16590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP8S17E03_16600	COG1842	Phage shock protein A
WP8S17E03_16640	COG3106	COG3106 Predicted ATPase
WP8S17E03_16650	COG3768	UPF0283 membrane protein
WP8S17E03_16670	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP8S17E03_16710	COG2885	chlorophyll binding
WP8S17E03_16730	COG1570	exodeoxyribonuclease VII activity
WP8S17E03_16750	COG0366	Alpha amylase catalytic
WP8S17E03_16750	COG1874	Beta-galactosidase
WP8S17E03_16770	COG0517	IMP dehydrogenase activity
WP8S17E03_16770	COG0516	GMP reductase activity
WP8S17E03_16780	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S17E03_16780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S17E03_16800	COG3039	Transposase
WP8S17E03_16850	COG1846	Transcriptional regulator
WP8S17E03_16890	COG2062	phosphohistidine phosphatase, SixA
WP8S17E03_16910	COG0697	spore germination
WP8S17E03_16930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP8S17E03_16940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP8S17E03_16960	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S17E03_16970	COG1136	(ABC) transporter
WP8S17E03_16980	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S17E03_16990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP8S17E03_17010	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP8S17E03_17020	COG0740	serine-type endopeptidase activity
WP8S17E03_17030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP8S17E03_17040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP8S17E03_17050	COG0776	regulation of translation
WP8S17E03_17060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S17E03_17070	COG0488	(ABC) transporter
WP8S17E03_17080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S17E03_17090	COG3162	membrane
WP8S17E03_17120	COG1024	Enoyl-CoA hydratase
WP8S17E03_17130	COG1115	amino acid carrier protein
WP8S17E03_17150	COG3228	Belongs to the MtfA family
WP8S17E03_17160	COG1584	GPR1 FUN34 yaaH family protein
WP8S17E03_17220	COG1024	Enoyl-CoA hydratase
WP8S17E03_17230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP8S17E03_17240	COG1960	acyl-CoA dehydrogenase activity
WP8S17E03_17260	COG1960	acyl-CoA dehydrogenase activity
WP8S17E03_17270	COG1024	Enoyl-CoA hydratase
WP8S17E03_17280	COG1024	Enoyl-CoA hydratase
WP8S17E03_17300	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S17E03_17320	COG0730	response to heat
WP8S17E03_17360	COG3039	Transposase
WP8S17E03_17370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8S17E03_17440	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S17E03_17450	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S17E03_17460	COG1129	ABC transporter
WP8S17E03_17470	COG1879	ABC-type sugar transport system periplasmic component
WP8S17E03_17480	COG0583	DNA-binding transcription factor activity
WP8S17E03_17510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP8S17E03_17520	COG0243	molybdopterin cofactor binding
WP8S17E03_17540	COG0583	DNA-binding transcription factor activity
WP8S17E03_17550	COG2723	6-phospho-beta-galactosidase activity
WP8S17E03_17570	COG0583	DNA-binding transcription factor activity
WP8S17E03_17600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP8S17E03_17610	COG0673	inositol 2-dehydrogenase activity
WP8S17E03_17620	COG0583	DNA-binding transcription factor activity
WP8S17E03_17640	COG1560	Kdo2-lipid A biosynthetic process
WP8S17E03_17650	COG1560	Kdo2-lipid A biosynthetic process
WP8S17E03_17680	COG0417	DNA replication proofreading
WP8S17E03_17690	COG0534	Mate efflux family protein
WP8S17E03_17710	COG0307	riboflavin synthase, alpha
WP8S17E03_17740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S17E03_17750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP8S17E03_17760	COG0697	spore germination
WP8S17E03_17770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP8S17E03_17820	COG0675	Transposase, IS605 OrfB family
WP8S17E03_17830	COG2996	Protein conserved in bacteria
WP8S17E03_17860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S17E03_17870	COG3099	Belongs to the UPF0263 family
WP8S17E03_17880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP8S17E03_17890	COG2894	cell division
WP8S17E03_17900	COG0850	regulation of cytokinetic process
WP8S17E03_17910	COG3100	YcgL domain-containing protein
WP8S17E03_17920	COG2951	lytic endotransglycosylase activity
WP8S17E03_17930	COG1760	l-serine dehydratase
WP8S17E03_17940	COG1760	l-serine dehydratase
WP8S17E03_17950	COG3123	guanosine phosphorylase activity
WP8S17E03_17960	COG1301	dicarboxylic acid transport
WP8S17E03_17990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP8S17E03_18000	COG2067	long-chain fatty acid transport protein
WP8S17E03_18010	COG2067	long-chain fatty acid transport protein
WP8S17E03_18030	COG1595	DNA-templated transcription, initiation
WP8S17E03_18090	COG0714	Associated with various cellular activities
WP8S17E03_18100	COG0183	Belongs to the thiolase family
WP8S17E03_18110	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S17E03_18110	COG1024	Enoyl-CoA hydratase
WP8S17E03_18130	COG4681	YaeQ
WP8S17E03_18170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S17E03_18200	COG3134	Outer membrane lipoprotein
WP8S17E03_18220	COG0675	Transposase, IS605 OrfB family
WP8S17E03_18230	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S17E03_18240	COG2378	regulation of single-species biofilm formation
WP8S17E03_18260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP8S17E03_18260	COG0140	phosphoribosyl-ATP diphosphatase activity
WP8S17E03_18270	COG0107	imidazoleglycerol-phosphate synthase activity
WP8S17E03_18280	COG2205	protein histidine kinase activity
WP8S17E03_18280	COG2198	Histidine kinase
WP8S17E03_18280	COG0784	Response regulator, receiver
WP8S17E03_18300	COG3437	response regulator, receiver
WP8S17E03_18310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP8S17E03_18320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP8S17E03_18330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S17E03_18330	COG0131	Imidazoleglycerol-phosphate dehydratase
WP8S17E03_18340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP8S17E03_18350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP8S17E03_18360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP8S17E03_18380	COG1199	ATP-dependent helicase activity
WP8S17E03_18390	COG1214	PFAM Peptidase M22, glycoprotease
WP8S17E03_18410	COG0596	Alpha beta hydrolase
WP8S17E03_18420	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S17E03_18430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WP8S17E03_18460	COG0697	spore germination
WP8S17E03_18480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S17E03_18490	COG2832	Protein of unknown function (DUF454)
WP8S17E03_18500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP8S17E03_18520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP8S17E03_18530	COG0583	DNA-binding transcription factor activity
WP8S17E03_18560	COG2197	response regulator
WP8S17E03_18570	COG0517	IMP dehydrogenase activity
WP8S17E03_18570	COG0617	tRNA 3'-terminal CCA addition
WP8S17E03_18570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8S17E03_18580	COG1643	Atp-dependent helicase
WP8S17E03_18600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP8S17E03_18610	COG3437	response regulator, receiver
WP8S17E03_18610	COG2205	protein histidine kinase activity
WP8S17E03_18610	COG4999	Histidine kinase
WP8S17E03_18610	COG3850	Histidine kinase
WP8S17E03_18640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S17E03_18650	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP8S17E03_18660	COG0709	Synthesizes selenophosphate from selenide and ATP
WP8S17E03_18690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S17E03_18700	COG0840	transmembrane signaling receptor activity
WP8S17E03_18710	COG1254	Belongs to the acylphosphatase family
WP8S17E03_18730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S17E03_18730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S17E03_18740	COG0489	protein tyrosine kinase activity
WP8S17E03_18750	COG0572	uridine kinase
WP8S17E03_18760	COG0717	Belongs to the dCTP deaminase family
WP8S17E03_18770	COG0306	phosphate transporter
WP8S17E03_18780	COG1530	ribonuclease E activity
WP8S17E03_18790	COG0564	pseudouridine synthase activity
WP8S17E03_18830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP8S17E03_18840	COG0416	fatty acid biosynthetic process
WP8S17E03_18850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP8S17E03_18870	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S17E03_18880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP8S17E03_18890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8S17E03_18900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP8S17E03_18910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP8S17E03_18920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP8S17E03_18930	COG0470	DNA polymerase III
WP8S17E03_18940	COG0084	hydrolase, TatD family'
WP8S17E03_19070	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP8S17E03_19070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S17E03_19080	COG3008	intermembrane lipid transfer
WP8S17E03_19090	COG2995	paraquat-inducible protein a
WP8S17E03_19110	COG3141	response to X-ray
WP8S17E03_19130	COG1067	ATP-dependent peptidase activity
WP8S17E03_19140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S17E03_19180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S17E03_19180	COG0116	Belongs to the methyltransferase superfamily
WP8S17E03_19200	COG0167	dihydroorotate dehydrogenase activity
WP8S17E03_19210	COG2902	Dehydrogenase
WP8S17E03_19230	COG0308	aminopeptidase N
WP8S17E03_19250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP8S17E03_19260	COG1956	GAF domain-containing protein
WP8S17E03_19280	COG3278	Belongs to the heme-copper respiratory oxidase family
WP8S17E03_19310	COG2010	Cytochrome c
WP8S17E03_19330	COG2217	Heavy metal translocating P-type atpase
WP8S17E03_19360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S17E03_19370	COG0589	response to stress
WP8S17E03_19380	COG0037	tRNA processing
WP8S17E03_19410	COG0625	glutathione transferase activity
WP8S17E03_19440	COG0840	transmembrane signaling receptor activity
WP8S17E03_19450	COG4772	TonB-dependent receptor
WP8S17E03_19490	COG3335	DDE superfamily endonuclease
WP8S17E03_19510	COG1869	D-ribose catabolic process
WP8S17E03_19520	COG1129	ABC transporter
WP8S17E03_19530	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S17E03_19540	COG1879	ABC-type sugar transport system periplasmic component
WP8S17E03_19550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S17E03_19560	COG1609	Transcriptional regulator
WP8S17E03_19590	COG3300	MHYT domain
WP8S17E03_19590	COG5001	Diguanylate cyclase
WP8S17E03_19660	COG0776	regulation of translation
WP8S17E03_19670	COG0072	phenylalanine-tRNA ligase activity
WP8S17E03_19670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S17E03_19680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP8S17E03_19690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP8S17E03_19700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP8S17E03_19710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP8S17E03_19720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP8S17E03_19780	COG0675	Transposase, IS605 OrfB family
WP8S17E03_19820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S17E03_19840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S17E03_19850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S17E03_19860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S17E03_19870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP8S17E03_19880	COG3313	Fe-S protein
WP8S17E03_19890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S17E03_19890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S17E03_19890	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP8S17E03_19900	COG1105	Belongs to the carbohydrate kinase PfkB family
WP8S17E03_19910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_19910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_19920	COG1609	Transcriptional regulator
WP8S17E03_19930	COG0814	amino acid
WP8S17E03_19950	COG5654	RES domain protein
WP8S17E03_19960	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_19980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP8S17E03_19990	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S17E03_20000	COG2840	Smr protein MutS2
WP8S17E03_20080	COG2824	Alkylphosphonate utilization operon protein PhnA
WP8S17E03_20110	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_20190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8S17E03_20200	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP8S17E03_20220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S17E03_20230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP8S17E03_20250	COG0205	6-phosphofructokinase activity
WP8S17E03_20260	COG1473	amidohydrolase
WP8S17E03_20270	COG1011	Hydrolase
WP8S17E03_20280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S17E03_20300	COG3593	DNA synthesis involved in DNA repair
WP8S17E03_20330	COG0583	DNA-binding transcription factor activity
WP8S17E03_20340	COG0730	response to heat
WP8S17E03_20360	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP8S17E03_20380	COG0386	Belongs to the glutathione peroxidase family
WP8S17E03_20390	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_20450	COG2329	Antibiotic biosynthesis monooxygenase
WP8S17E03_20460	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8S17E03_20500	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP8S17E03_20510	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP8S17E03_20530	COG2501	S4 domain
WP8S17E03_20560	COG1132	(ABC) transporter
WP8S17E03_20570	COG1132	(ABC) transporter
WP8S17E03_20590	COG3118	belongs to the thioredoxin family
WP8S17E03_20600	COG0471	metal ion transport
WP8S17E03_20620	COG0058	SHG alpha-glucan phosphorylase activity
WP8S17E03_20690	COG0814	amino acid
WP8S17E03_20700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP8S17E03_20710	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S17E03_20720	COG2766	serine protein kinase
WP8S17E03_20730	COG2718	Belongs to the UPF0229 family
WP8S17E03_20740	COG2719	SpoVR family
WP8S17E03_20750	COG2186	Transcriptional regulator
WP8S17E03_20760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S17E03_20770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP8S17E03_20780	COG0586	Pfam SNARE associated Golgi protein
WP8S17E03_20800	COG0556	nucleotide-excision repair
WP8S17E03_20820	COG0569	domain protein
WP8S17E03_20820	COG2985	domain, Protein
WP8S17E03_20830	COG0739	heme binding
WP8S17E03_20830	COG0741	lytic transglycosylase activity
WP8S17E03_20830	COG1196	nuclear chromosome segregation
WP8S17E03_20840	COG3181	Tripartite tricarboxylate transporter family receptor
WP8S17E03_20870	COG4565	transcriptional regulatory protein
WP8S17E03_20880	COG3290	protein histidine kinase activity
WP8S17E03_20890	COG1940	carbohydrate kinase activity
WP8S17E03_20890	COG1846	Transcriptional regulator
WP8S17E03_20900	COG0840	transmembrane signaling receptor activity
WP8S17E03_20910	COG3012	SEC-C Motif Domain Protein
WP8S17E03_20920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP8S17E03_20930	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP8S17E03_20950	COG0247	lactate metabolic process
WP8S17E03_20980	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP8S17E03_20990	COG0437	4 iron, 4 sulfur cluster binding
WP8S17E03_21000	COG3301	Polysulphide reductase, NrfD
WP8S17E03_21020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S17E03_21030	COG4235	cytochrome complex assembly
WP8S17E03_21030	COG3088	subunit of a heme lyase
WP8S17E03_21060	COG3046	protein related to deoxyribodipyrimidine photolyase
WP8S17E03_21070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S17E03_21100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8S17E03_21100	COG0617	tRNA 3'-terminal CCA addition
WP8S17E03_21100	COG0517	IMP dehydrogenase activity
WP8S17E03_21120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP8S17E03_21130	COG0583	DNA-binding transcription factor activity
WP8S17E03_21150	COG4774	siderophore transport
WP8S17E03_21160	COG2199	diguanylate cyclase activity
WP8S17E03_21160	COG2203	Gaf domain
WP8S17E03_21170	COG2200	EAL domain
WP8S17E03_21180	COG1917	Cupin 2, conserved barrel domain protein
WP8S17E03_21180	COG4977	sequence-specific DNA binding
WP8S17E03_21190	COG0583	DNA-binding transcription factor activity
WP8S17E03_21200	COG2910	NAD(P)H-binding
WP8S17E03_21230	COG0626	cystathionine gamma-synthase activity
WP8S17E03_21240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP8S17E03_21300	COG5433	transposase activity
WP8S17E03_21310	COG2801	Transposase and inactivated derivatives
WP8S17E03_21340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8S17E03_21350	COG3039	Transposase
WP8S17E03_21380	COG3039	Transposase
WP8S17E03_21470	COG3335	DDE superfamily endonuclease
WP8S17E03_21510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP8S17E03_21520	COG0830	nickel cation binding
WP8S17E03_21540	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
WP8S17E03_21550	COG0804	urea catabolic process
WP8S17E03_21560	COG0832	Belongs to the urease beta subunit family
WP8S17E03_21570	COG0831	urea catabolic process
WP8S17E03_21580	COG0829	nickel cation binding
WP8S17E03_21600	COG0411	ABC transporter
WP8S17E03_21650	COG0784	Response regulator, receiver
WP8S17E03_21650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_21650	COG2198	Histidine kinase
WP8S17E03_21650	COG2205	protein histidine kinase activity
WP8S17E03_21660	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_21800	COG3550	peptidyl-serine autophosphorylation
WP8S17E03_21810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP8S17E03_21840	COG2723	6-phospho-beta-galactosidase activity
WP8S17E03_21850	COG1263	PTS System
WP8S17E03_21850	COG2190	(PTS) system
WP8S17E03_21850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_21860	COG1737	Transcriptional regulator
WP8S17E03_21890	COG1435	thymidine kinase activity
WP8S17E03_21900	COG1757	Na H antiporter
WP8S17E03_21910	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8S17E03_21920	COG2096	Adenosyltransferase
WP8S17E03_21930	COG3530	Putative quorum-sensing-regulated virulence factor
WP8S17E03_21940	COG0602	queuosine metabolic process
WP8S17E03_21950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP8S17E03_21990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP8S17E03_22010	COG0776	regulation of translation
WP8S17E03_22020	COG0539	negative regulation of cytoplasmic translation
WP8S17E03_22030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP8S17E03_22040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S17E03_22100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP8S17E03_22110	COG5001	Diguanylate cyclase
WP8S17E03_22110	COG3300	MHYT domain
WP8S17E03_22130	COG0583	DNA-binding transcription factor activity
WP8S17E03_22140	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_22190	COG4989	oxidoreductase activity
WP8S17E03_22200	COG0724	RNA recognition motif
WP8S17E03_22220	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
WP8S17E03_22240	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP8S17E03_22260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S17E03_22270	COG1360	Flagellar Motor Protein
WP8S17E03_22280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S17E03_22290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S17E03_22300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S17E03_22300	COG0649	NAD binding
WP8S17E03_22330	COG1034	ATP synthesis coupled electron transport
WP8S17E03_22340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP8S17E03_22350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S17E03_22360	COG0839	Belongs to the complex I subunit 6 family
WP8S17E03_22370	COG0713	ATP synthesis coupled electron transport
WP8S17E03_22390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S17E03_22400	COG1007	ATP synthesis coupled electron transport
WP8S17E03_22410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP8S17E03_22410	COG0047	phosphoribosylformylglycinamidine synthase activity
WP8S17E03_22420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S17E03_22440	COG1645	bacterial-type flagellum-dependent swarming motility
WP8S17E03_22450	COG1160	GTP binding
WP8S17E03_22460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S17E03_22470	COG2976	Protein conserved in bacteria
WP8S17E03_22480	COG0124	histidyl-tRNA synthetase
WP8S17E03_22500	COG1426	Protein conserved in bacteria
WP8S17E03_22520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP8S17E03_22530	COG0105	UTP biosynthetic process
WP8S17E03_22560	COG0633	Ferredoxin
WP8S17E03_22570	COG0443	Heat shock 70 kDa protein
WP8S17E03_22580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S17E03_22600	COG0822	iron-sulfur transferase activity
WP8S17E03_22610	COG1104	cysteine desulfurase activity
WP8S17E03_22640	COG3154	lipid carrier protein
WP8S17E03_22650	COG0826	peptidase U32
WP8S17E03_22660	COG0826	peptidase U32
WP8S17E03_22680	COG2897	thiosulfate sulfurtransferase activity
WP8S17E03_22690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S17E03_22700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S17E03_22710	COG1862	Preprotein translocase
WP8S17E03_22720	COG0343	queuine tRNA-ribosyltransferase activity
WP8S17E03_22730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP8S17E03_22740	COG0517	IMP dehydrogenase activity
WP8S17E03_22750	COG0450	alkyl hydroperoxide reductase
WP8S17E03_22760	COG3634	alkyl hydroperoxide reductase activity
WP8S17E03_22810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S17E03_22810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S17E03_22820	COG0509	glycine decarboxylation via glycine cleavage system
WP8S17E03_22830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP8S17E03_22840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S17E03_22850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S17E03_22880	COG2814	Major facilitator Superfamily
WP8S17E03_22890	COG0444	Belongs to the ABC transporter superfamily
WP8S17E03_22900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S17E03_22910	COG0601	transmembrane transport
WP8S17E03_22930	COG0625	glutathione transferase activity
WP8S17E03_22940	COG0625	glutathione transferase activity
WP8S17E03_22960	COG0483	inositol monophosphate 1-phosphatase activity
WP8S17E03_22990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S17E03_23000	COG2056	Na+-H+ antiporter family
WP8S17E03_23010	COG2814	Major facilitator Superfamily
WP8S17E03_23020	COG0583	DNA-binding transcription factor activity
WP8S17E03_23030	COG5001	Diguanylate cyclase
WP8S17E03_23060	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S17E03_23080	COG0247	lactate metabolic process
WP8S17E03_23080	COG0277	FAD linked oxidase domain protein
WP8S17E03_23110	COG1253	flavin adenine dinucleotide binding
WP8S17E03_23120	COG1902	pentaerythritol trinitrate reductase activity
WP8S17E03_23140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8S17E03_23150	COG0647	UMP catabolic process
WP8S17E03_23170	COG0367	asparagine synthase
WP8S17E03_23200	COG0625	glutathione transferase activity
WP8S17E03_23220	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP8S17E03_23250	COG0564	pseudouridine synthase activity
WP8S17E03_23260	COG5001	Diguanylate cyclase
WP8S17E03_23280	COG0840	transmembrane signaling receptor activity
WP8S17E03_23290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP8S17E03_23360	COG0670	Belongs to the BI1 family
WP8S17E03_23370	COG1289	transmembrane transporter activity
WP8S17E03_23380	COG2920	part of a sulfur-relay system
WP8S17E03_23390	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP8S17E03_23400	COG0285	dihydrofolate synthase activity
WP8S17E03_23410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP8S17E03_23420	COG0101	tRNA pseudouridine synthase activity
WP8S17E03_23440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S17E03_23450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S17E03_23470	COG1464	Belongs to the NlpA lipoprotein family
WP8S17E03_23520	COG1119	ATPase activity
WP8S17E03_23530	COG0574	Belongs to the PEP-utilizing enzyme family
WP8S17E03_23530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP8S17E03_23540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP8S17E03_23560	COG1113	amino acid transport
WP8S17E03_23650	COG1242	4 iron, 4 sulfur cluster binding
WP8S17E03_23660	COG0067	glutamate synthase
WP8S17E03_23660	COG0069	glutamate synthase activity
WP8S17E03_23660	COG0070	glutamate synthase
WP8S17E03_23670	COG0493	'glutamate synthase
WP8S17E03_23690	COG0765	amino acid transport
WP8S17E03_23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_23750	COG4104	PAAR repeat-containing protein
WP8S17E03_23770	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_23810	COG3039	Transposase
WP8S17E03_23830	COG3706	GGDEF domain
WP8S17E03_23840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8S17E03_23850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP8S17E03_23860	COG0505	Belongs to the CarA family
WP8S17E03_23870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP8S17E03_23890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP8S17E03_23900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP8S17E03_23910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S17E03_23920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8S17E03_23930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S17E03_23940	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP8S17E03_23950	COG4139	cobalamin transport
WP8S17E03_24000	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP8S17E03_24020	COG0023	Translation Initiation Factor
WP8S17E03_24030	COG2119	membrane
WP8S17E03_24100	COG2199	diguanylate cyclase activity
WP8S17E03_24100	COG2203	Gaf domain
WP8S17E03_24140	COG2801	Transposase and inactivated derivatives
WP8S17E03_24170	COG0215	cysteine-tRNA ligase activity
WP8S17E03_24180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S17E03_24200	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S17E03_24210	COG2261	transglycosylase associated protein
WP8S17E03_24220	COG1309	transcriptional regulator
WP8S17E03_24230	COG0604	alcohol dehydrogenase
WP8S17E03_24260	COG0583	DNA-binding transcription factor activity
WP8S17E03_24280	COG0322	excinuclease ABC activity
WP8S17E03_24290	COG2197	response regulator
WP8S17E03_24300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP8S17E03_24310	COG2835	tetraacyldisaccharide 4'-kinase activity
WP8S17E03_24320	COG1663	tetraacyldisaccharide 4'-kinase activity
WP8S17E03_24330	COG1132	(ABC) transporter
WP8S17E03_24340	COG0658	competence protein
WP8S17E03_24340	COG2333	competence protein COMEC
WP8S17E03_24370	COG0433	COG0433 Predicted ATPase
WP8S17E03_24380	COG1448	Aminotransferase
WP8S17E03_24410	COG1199	ATP-dependent helicase activity
WP8S17E03_24430	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP8S17E03_24440	COG0477	Major facilitator Superfamily
WP8S17E03_24450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP8S17E03_24460	COG1785	Belongs to the alkaline phosphatase family
WP8S17E03_24510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S17E03_24520	COG3706	GGDEF domain
WP8S17E03_24530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_24540	COG0765	amino acid transport
WP8S17E03_24550	COG1126	abc transporter atp-binding protein
WP8S17E03_24570	COG0531	amino acid
WP8S17E03_24600	COG1253	flavin adenine dinucleotide binding
WP8S17E03_24610	COG0704	Plays a role in the regulation of phosphate uptake
WP8S17E03_24630	COG0581	inorganic phosphate transmembrane transporter activity
WP8S17E03_24640	COG0573	inorganic phosphate transmembrane transporter activity
WP8S17E03_24650	COG0590	tRNA wobble adenosine to inosine editing
WP8S17E03_24670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP8S17E03_24710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP8S17E03_24720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP8S17E03_24730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP8S17E03_24740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP8S17E03_24760	COG3852	Histidine kinase
WP8S17E03_24800	COG2716	regulation of RNA biosynthetic process
WP8S17E03_24810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP8S17E03_24830	COG2239	Acts as a magnesium transporter
WP8S17E03_24860	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP8S17E03_24860	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP8S17E03_24870	COG1706	bacterial-type flagellum-dependent cell motility
WP8S17E03_24880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP8S17E03_24910	COG1749	Flagellar hook protein flgE
WP8S17E03_24940	COG1815	bacterial-type flagellum-dependent cell motility
WP8S17E03_24950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP8S17E03_24960	COG0835	chemotaxis
WP8S17E03_24960	COG0784	Response regulator, receiver
WP8S17E03_24970	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP8S17E03_25000	COG0622	Phosphoesterase
WP8S17E03_25010	COG4166	transmembrane transport
WP8S17E03_25040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S17E03_25060	COG0697	spore germination
WP8S17E03_25120	COG1278	Cold shock
WP8S17E03_25200	COG3132	Protein of unknown function, DUF480
WP8S17E03_25260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S17E03_25270	COG3039	Transposase
WP8S17E03_25290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WP8S17E03_25300	COG1596	polysaccharide export
WP8S17E03_25330	COG0297	glycogen (starch) synthase activity
WP8S17E03_25340	COG0438	transferase activity, transferring glycosyl groups
WP8S17E03_25400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8S17E03_25420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S17E03_25450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S17E03_25560	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP8S17E03_25580	COG3039	Transposase
WP8S17E03_25590	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_25620	COG1737	Transcriptional regulator
WP8S17E03_25630	COG0469	pyruvate kinase activity
WP8S17E03_25650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_25660	COG1960	acyl-CoA dehydrogenase activity
WP8S17E03_25680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP8S17E03_25710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_25720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_25730	COG1309	transcriptional regulator
WP8S17E03_25760	COG1946	Acyl-CoA thioesterase
WP8S17E03_25790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP8S17E03_25810	COG0009	L-threonylcarbamoyladenylate synthase
WP8S17E03_25820	COG0613	PHP domain protein
WP8S17E03_25830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP8S17E03_25850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S17E03_25850	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8S17E03_25860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S17E03_25870	COG0134	indole-3-glycerol-phosphate synthase activity
WP8S17E03_25870	COG0135	phosphoribosylanthranilate isomerase activity
WP8S17E03_25880	COG0133	tryptophan synthase activity
WP8S17E03_25890	COG0159	tryptophan synthase activity
WP8S17E03_25990	COG4521	taurine ABC transporter
WP8S17E03_26000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WP8S17E03_26010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP8S17E03_26020	COG2175	clavaminate synthase activity
WP8S17E03_26030	COG5507	3-demethylubiquinone-9 3-methyltransferase
WP8S17E03_26040	COG2814	Major facilitator Superfamily
WP8S17E03_26050	COG0109	protoheme IX farnesyltransferase activity
WP8S17E03_26060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP8S17E03_26070	COG1845	cytochrome c oxidase, subunit III
WP8S17E03_26080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP8S17E03_26090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP8S17E03_26100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8S17E03_26110	COG0583	DNA-binding transcription factor activity
WP8S17E03_26140	COG0675	Transposase, IS605 OrfB family
WP8S17E03_26160	COG1846	Transcriptional regulator
WP8S17E03_26190	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WP8S17E03_26220	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_26240	COG0708	Exodeoxyribonuclease III
WP8S17E03_26260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_26270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_26300	COG0095	Lipoate-protein ligase
WP8S17E03_26360	COG0640	Transcriptional regulator
WP8S17E03_26380	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S17E03_26400	COG1285	pathogenesis
WP8S17E03_26460	COG0484	heat shock protein binding
WP8S17E03_26470	COG0443	Heat shock 70 kDa protein
WP8S17E03_26480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP8S17E03_26490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP8S17E03_26500	COG3706	GGDEF domain
WP8S17E03_26510	COG0497	DNA recombination
WP8S17E03_26530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_26540	COG0577	efflux transmembrane transporter activity
WP8S17E03_26540	COG1136	(ABC) transporter
WP8S17E03_26560	COG2375	cellular response to nickel ion
WP8S17E03_26570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S17E03_26580	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8S17E03_26590	COG3039	Transposase
WP8S17E03_26600	COG0583	DNA-binding transcription factor activity
WP8S17E03_26610	COG3048	D-serine ammonia-lyase activity
WP8S17E03_26630	COG0538	isocitrate dehydrogenase activity
WP8S17E03_26690	COG0456	acetyltransferase
WP8S17E03_26700	COG1187	pseudouridine synthase activity
WP8S17E03_26720	COG0482	sulfurtransferase activity
WP8S17E03_26730	COG2915	High frequency lysogenization protein hflD homolog
WP8S17E03_26740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP8S17E03_26750	COG2850	peptidyl-arginine hydroxylation
WP8S17E03_26770	COG3264	Mechanosensitive ion channel
WP8S17E03_26770	COG1196	nuclear chromosome segregation
WP8S17E03_26830	COG0281	malic enzyme
WP8S17E03_26840	COG0746	molybdenum cofactor guanylyltransferase activity
WP8S17E03_26850	COG1763	Mo-molybdopterin cofactor biosynthetic process
WP8S17E03_26860	COG1289	transmembrane transporter activity
WP8S17E03_26870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S17E03_26930	COG3220	belongs to the UPF0276 family
WP8S17E03_26950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP8S17E03_26980	COG3039	Transposase
WP8S17E03_26990	COG3039	Transposase
WP8S17E03_27030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S17E03_27040	COG0083	homoserine kinase activity
WP8S17E03_27060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP8S17E03_27070	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP8S17E03_27100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S17E03_27130	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_27140	COG4988	ABC transporter
WP8S17E03_27150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP8S17E03_27200	COG1720	tRNA m6t6A37 methyltransferase activity
WP8S17E03_27230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP8S17E03_27240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP8S17E03_27250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_27270	COG2190	(PTS) system
WP8S17E03_27280	COG3038	cytochrome b561
WP8S17E03_27300	COG0420	3'-5' exonuclease activity
WP8S17E03_27310	COG1247	-acetyltransferase
WP8S17E03_27320	COG2974	May be involved in recombination
WP8S17E03_27340	COG0405	Gamma-glutamyltransferase
WP8S17E03_27350	COG4651	solute:proton antiporter activity
WP8S17E03_27350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP8S17E03_27420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S17E03_27430	COG1917	Cupin 2, conserved barrel domain protein
WP8S17E03_27430	COG1396	sequence-specific DNA binding
WP8S17E03_27440	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_27470	COG0531	amino acid
WP8S17E03_27490	COG0531	amino acid
WP8S17E03_27510	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP8S17E03_27530	COG3384	dioxygenase
WP8S17E03_27540	COG2205	protein histidine kinase activity
WP8S17E03_27540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_27570	COG0784	Response regulator, receiver
WP8S17E03_27570	COG2205	protein histidine kinase activity
WP8S17E03_27580	COG1376	ErfK ybiS ycfS ynhG family protein
WP8S17E03_27580	COG1388	LysM domain
WP8S17E03_27610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP8S17E03_27620	COG0791	NLP P60 protein
WP8S17E03_27640	COG3118	belongs to the thioredoxin family
WP8S17E03_27650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S17E03_27660	COG0788	formyltetrahydrofolate deformylase activity
WP8S17E03_27710	COG0739	heme binding
WP8S17E03_27710	COG1196	nuclear chromosome segregation
WP8S17E03_27710	COG0741	lytic transglycosylase activity
WP8S17E03_27720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S17E03_27730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP8S17E03_27740	COG0673	inositol 2-dehydrogenase activity
WP8S17E03_27810	COG1032	radical SAM domain protein
WP8S17E03_27820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_27840	COG3706	GGDEF domain
WP8S17E03_27850	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S17E03_27860	COG0733	neurotransmitter:sodium symporter activity
WP8S17E03_27870	COG3335	DDE superfamily endonuclease
WP8S17E03_27940	COG0281	malic enzyme
WP8S17E03_27950	COG2207	Transcriptional regulator
WP8S17E03_27990	COG2233	PERMEase
WP8S17E03_28000	COG0095	Lipoate-protein ligase
WP8S17E03_28010	COG1115	amino acid carrier protein
WP8S17E03_28020	COG0019	diaminopimelate decarboxylase activity
WP8S17E03_28040	COG0678	peroxiredoxin activity
WP8S17E03_28050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP8S17E03_28070	COG1126	abc transporter atp-binding protein
WP8S17E03_28080	COG0765	amino acid transport
WP8S17E03_28090	COG4597	amino acid ABC transporter
WP8S17E03_28100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_28130	COG1131	(ABC) transporter
WP8S17E03_28140	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S17E03_28150	COG3142	Participates in the control of copper homeostasis
WP8S17E03_28160	COG1940	carbohydrate kinase activity
WP8S17E03_28180	COG4783	chaperone-mediated protein folding
WP8S17E03_28200	COG5002	protein histidine kinase activity
WP8S17E03_28210	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_28220	COG0346	lactoylglutathione lyase activity
WP8S17E03_28230	COG3706	GGDEF domain
WP8S17E03_28240	COG3284	Transcriptional regulator
WP8S17E03_28250	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_28270	COG0697	spore germination
WP8S17E03_28290	COG0667	Aldo Keto reductase
WP8S17E03_28320	COG3290	protein histidine kinase activity
WP8S17E03_28340	COG1566	PFAM secretion protein HlyD family protein
WP8S17E03_28390	COG0602	queuosine metabolic process
WP8S17E03_28400	COG1328	CTP reductase activity
WP8S17E03_28420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP8S17E03_28430	COG3115	cell septum assembly
WP8S17E03_28440	COG1196	nuclear chromosome segregation
WP8S17E03_28460	COG2860	membrane
WP8S17E03_28480	COG3108	Peptidase M15
WP8S17E03_28490	COG2989	Protein conserved in bacteria
WP8S17E03_28520	COG0463	Glycosyl transferase, family 2
WP8S17E03_28550	COG0366	Alpha amylase catalytic
WP8S17E03_28620	COG3706	GGDEF domain
WP8S17E03_28630	COG0037	tRNA processing
WP8S17E03_28660	COG0488	(ABC) transporter
WP8S17E03_28680	COG0531	amino acid
WP8S17E03_28690	COG0814	amino acid
WP8S17E03_28720	COG0825	malonyl-CoA metabolic process
WP8S17E03_28730	COG0587	DNA-directed DNA polymerase activity
WP8S17E03_28740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP8S17E03_28750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S17E03_28760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S17E03_28770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S17E03_28780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S17E03_28810	COG0750	zinc metalloprotease
WP8S17E03_28820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP8S17E03_28830	COG0575	Belongs to the CDS family
WP8S17E03_28840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP8S17E03_28850	COG0233	cytoplasmic translational termination
WP8S17E03_28860	COG0528	UMP kinase activity
WP8S17E03_28870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP8S17E03_28880	COG0052	Belongs to the universal ribosomal protein uS2 family
WP8S17E03_28890	COG0024	Methionine aminopeptidase
WP8S17E03_28900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP8S17E03_28910	COG2171	N-acyltransferase activity
WP8S17E03_28930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_28930	COG1263	PTS System
WP8S17E03_28950	COG4580	involved in the transport of maltose and maltodextrins
WP8S17E03_28980	COG0564	pseudouridine synthase activity
WP8S17E03_28990	COG3098	single-species biofilm formation
WP8S17E03_29040	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP8S17E03_29060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S17E03_29060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S17E03_29090	COG3706	GGDEF domain
WP8S17E03_29100	COG1611	Belongs to the LOG family
WP8S17E03_29110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S17E03_29120	COG0473	3-isopropylmalate dehydrogenase activity
WP8S17E03_29140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP8S17E03_29170	COG0583	DNA-binding transcription factor activity
WP8S17E03_29180	COG0840	transmembrane signaling receptor activity
WP8S17E03_29190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8S17E03_29220	COG1477	protein flavinylation
WP8S17E03_29230	COG2871	sodium ion transport
WP8S17E03_29240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S17E03_29250	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S17E03_29260	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S17E03_29270	COG1805	sodium ion transport
WP8S17E03_29280	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S17E03_29290	COG0271	Belongs to the BolA IbaG family
WP8S17E03_29300	COG2813	Specifically methylates the guanine in position
WP8S17E03_29320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S17E03_29340	COG2211	Major facilitator Superfamily
WP8S17E03_29360	COG1666	GTP binding
WP8S17E03_29390	COG0659	secondary active sulfate transmembrane transporter activity
WP8S17E03_29400	COG5002	protein histidine kinase activity
WP8S17E03_29410	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_29420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_29430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S17E03_29480	COG1609	Transcriptional regulator
WP8S17E03_29490	COG2182	Extracellular solute-binding protein
WP8S17E03_29500	COG0840	transmembrane signaling receptor activity
WP8S17E03_29510	COG1472	Belongs to the glycosyl hydrolase 3 family
WP8S17E03_29520	COG2273	Hydrolase Family 16
WP8S17E03_29520	COG5297	Belongs to the glycosyl hydrolase family 6
WP8S17E03_29530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S17E03_29550	COG2723	6-phospho-beta-galactosidase activity
WP8S17E03_29560	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP8S17E03_29590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S17E03_29610	COG1151	hydroxylamine reductase activity
WP8S17E03_29620	COG0783	Belongs to the Dps family
WP8S17E03_29670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP8S17E03_29700	COG4221	oxidoreductase activity
WP8S17E03_29720	COG0415	Belongs to the DNA photolyase family
WP8S17E03_29730	COG0789	Transcriptional regulator
WP8S17E03_29740	COG3272	Protein of unknown function (DUF1722)
WP8S17E03_29790	COG0077	Prephenate dehydratase
WP8S17E03_29790	COG1605	Chorismate mutase
WP8S17E03_29840	COG2133	pyrroloquinoline quinone binding
WP8S17E03_29860	COG1349	DNA-binding transcription factor activity
WP8S17E03_29870	COG2084	Dehydrogenase
WP8S17E03_29880	COG3395	kinase activity
WP8S17E03_29890	COG0235	Class ii aldolase
WP8S17E03_29900	COG3622	Belongs to the hyi family
WP8S17E03_29910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S17E03_29920	COG2610	gluconate transmembrane transporter activity
WP8S17E03_29940	COG0840	transmembrane signaling receptor activity
WP8S17E03_29960	COG0300	oxidoreductase activity
WP8S17E03_30010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP8S17E03_30050	COG3813	Protein conserved in bacteria
WP8S17E03_30070	COG0826	peptidase U32
WP8S17E03_30080	COG1280	lysine exporter protein (LysE YggA)
WP8S17E03_30120	COG2203	Gaf domain
WP8S17E03_30120	COG2200	EAL domain
WP8S17E03_30120	COG2199	diguanylate cyclase activity
WP8S17E03_30210	COG1566	PFAM secretion protein HlyD family protein
WP8S17E03_30230	COG0114	fumarate hydratase activity
WP8S17E03_30250	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP8S17E03_30250	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP8S17E03_30250	COG0506	proline dehydrogenase activity
WP8S17E03_30260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S17E03_30290	COG0737	Belongs to the 5'-nucleotidase family
WP8S17E03_30330	COG2204	response regulator
WP8S17E03_30340	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S17E03_30360	COG2900	Belongs to the SlyX family
WP8S17E03_30370	COG1047	Peptidyl-prolyl cis-trans
WP8S17E03_30380	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP8S17E03_30400	COG0784	Response regulator, receiver
WP8S17E03_30400	COG0835	chemotaxis
WP8S17E03_30410	COG0429	hydrolase of the alpha beta-hydrolase fold
WP8S17E03_30420	COG2203	Gaf domain
WP8S17E03_30420	COG3706	GGDEF domain
WP8S17E03_30420	COG4251	negative regulation of phosphorylation
WP8S17E03_30420	COG5001	Diguanylate cyclase
WP8S17E03_30430	COG3089	Belongs to the UPF0270 family
WP8S17E03_30440	COG3954	Phosphoribulokinase
WP8S17E03_30470	COG1765	OsmC-like protein
WP8S17E03_30490	COG2226	methyltransferase
WP8S17E03_30510	COG2205	protein histidine kinase activity
WP8S17E03_30510	COG2202	Pas domain
WP8S17E03_30520	COG2814	Major facilitator Superfamily
WP8S17E03_30570	COG0748	coenzyme F420 binding
WP8S17E03_30580	COG3721	Heme iron utilization protein
WP8S17E03_30600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S17E03_30650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WP8S17E03_30670	COG0463	Glycosyl transferase, family 2
WP8S17E03_30680	COG0741	lytic transglycosylase activity
WP8S17E03_30690	COG0488	(ABC) transporter
WP8S17E03_30710	COG2252	PERMEase
WP8S17E03_30720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S17E03_30730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP8S17E03_30740	COG3178	'Phosphotransferase
WP8S17E03_30750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP8S17E03_30780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP8S17E03_30790	COG2967	ApaG domain
WP8S17E03_30800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8S17E03_30820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP8S17E03_30830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S17E03_30850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP8S17E03_30860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP8S17E03_30870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP8S17E03_30880	COG0142	geranyltranstransferase activity
WP8S17E03_30890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP8S17E03_30900	COG0330	HflC and HflK could
WP8S17E03_30910	COG0330	HflC and HflK could
WP8S17E03_30920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP8S17E03_30930	COG1923	regulation of RNA biosynthetic process
WP8S17E03_30940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP8S17E03_30950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP8S17E03_30970	COG0802	atpase or kinase
WP8S17E03_30980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP8S17E03_30980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP8S17E03_31020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP8S17E03_31030	COG2011	ABC-type metal ion transport system permease component
WP8S17E03_31040	COG1464	Belongs to the NlpA lipoprotein family
WP8S17E03_31080	COG0784	Response regulator, receiver
WP8S17E03_31080	COG2205	protein histidine kinase activity
WP8S17E03_31110	COG5002	protein histidine kinase activity
WP8S17E03_31110	COG2198	Histidine kinase
WP8S17E03_31110	COG0784	Response regulator, receiver
WP8S17E03_31150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP8S17E03_31180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP8S17E03_31190	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP8S17E03_31200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S17E03_31210	COG2716	regulation of RNA biosynthetic process
WP8S17E03_31220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP8S17E03_31230	COG3013	Belongs to the UPF0304 family
WP8S17E03_31260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8S17E03_31270	COG0280	phosphate acetyltransferase
WP8S17E03_31270	COG0857	belongs to the CobB CobQ family
WP8S17E03_31280	COG0440	acetolactate synthase activity
WP8S17E03_31290	COG0028	Belongs to the TPP enzyme family
WP8S17E03_31320	COG0671	phosphoesterase, PA-phosphatase related
WP8S17E03_31340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8S17E03_31350	COG0473	3-isopropylmalate dehydrogenase activity
WP8S17E03_31360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP8S17E03_31370	COG0066	3-isopropylmalate dehydratase activity
WP8S17E03_31400	COG4143	(ABC) transporter
WP8S17E03_31410	COG1178	ABC-type Fe3 transport system permease component
WP8S17E03_31420	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP8S17E03_31430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP8S17E03_31450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S17E03_31470	COG0316	Belongs to the HesB IscA family
WP8S17E03_31490	COG0038	chloride channel
WP8S17E03_31500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP8S17E03_31530	COG0671	phosphoesterase, PA-phosphatase related
WP8S17E03_31550	COG0583	DNA-binding transcription factor activity
WP8S17E03_31560	COG2076	Multidrug Resistance protein
WP8S17E03_31580	COG0346	lactoylglutathione lyase activity
WP8S17E03_31590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S17E03_31600	COG1643	Atp-dependent helicase
WP8S17E03_31620	COG1489	DNA binding
WP8S17E03_31630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP8S17E03_31640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S17E03_31660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP8S17E03_31670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP8S17E03_31680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP8S17E03_31700	COG0842	Transport permease protein
WP8S17E03_31710	COG1131	(ABC) transporter
WP8S17E03_31740	COG0163	prenyltransferase activity
WP8S17E03_31750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S17E03_31760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP8S17E03_31790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP8S17E03_31820	COG1136	(ABC) transporter
WP8S17E03_31890	COG2801	Transposase and inactivated derivatives
WP8S17E03_31900	COG0529	Catalyzes the synthesis of activated sulfate
WP8S17E03_31910	COG3273	potassium ion transport
WP8S17E03_31910	COG0471	metal ion transport
WP8S17E03_31920	COG2895	sulfate adenylyltransferase (ATP) activity
WP8S17E03_31930	COG0175	sulfate reduction
WP8S17E03_31940	COG1648	precorrin-2 dehydrogenase activity
WP8S17E03_31940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S17E03_31950	COG0330	HflC and HflK could
WP8S17E03_31960	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP8S17E03_31980	COG0673	inositol 2-dehydrogenase activity
WP8S17E03_32000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP8S17E03_32010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8S17E03_32020	COG3036	rescue of stalled ribosome
WP8S17E03_32050	COG0138	bifunctional purine biosynthesis protein purh
WP8S17E03_32110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP8S17E03_32120	COG0358	DNA primase activity
WP8S17E03_32130	COG1610	YqeY-like protein
WP8S17E03_32140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP8S17E03_32150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP8S17E03_32170	COG4942	peptidase
WP8S17E03_32170	COG1388	LysM domain
WP8S17E03_32180	COG1238	metal cluster binding
WP8S17E03_32190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP8S17E03_32200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP8S17E03_32210	COG0585	pseudouridine synthase activity
WP8S17E03_32230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP8S17E03_32240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP8S17E03_32250	COG0148	phosphopyruvate hydratase activity
WP8S17E03_32260	COG0504	CTP synthase activity
WP8S17E03_32270	COG3956	TIGRFAM MazG family protein
WP8S17E03_32280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S17E03_32290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S17E03_32310	COG4807	Protein conserved in bacteria
WP8S17E03_32320	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP8S17E03_32330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP8S17E03_32340	COG1381	Involved in DNA repair and RecF pathway recombination
WP8S17E03_32360	COG0571	ribonuclease III activity
WP8S17E03_32370	COG0681	Belongs to the peptidase S26 family
WP8S17E03_32380	COG0481	GTPase activity
WP8S17E03_32410	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP8S17E03_32420	COG1595	DNA-templated transcription, initiation
WP8S17E03_32430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP8S17E03_32450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP8S17E03_32470	COG0583	DNA-binding transcription factor activity
WP8S17E03_32530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S17E03_32550	COG0126	phosphoglycerate kinase activity
WP8S17E03_32560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S17E03_32570	COG1940	carbohydrate kinase activity
WP8S17E03_32580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP8S17E03_32600	COG4991	sh3 domain protein
WP8S17E03_32610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S17E03_32640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP8S17E03_32650	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S17E03_32670	COG1505	serine-type exopeptidase activity
WP8S17E03_32680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S17E03_32690	COG0765	amino acid transport
WP8S17E03_32710	COG0765	amino acid transport
WP8S17E03_32720	COG1126	abc transporter atp-binding protein
WP8S17E03_32730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S17E03_32740	COG3174	membrane
WP8S17E03_32750	COG0110	maltose O-acetyltransferase activity
WP8S17E03_32810	COG1942	4-Oxalocrotonate Tautomerase
WP8S17E03_32830	COG0583	DNA-binding transcription factor activity
WP8S17E03_32840	COG0165	Argininosuccinate lyase
WP8S17E03_32850	COG0137	argininosuccinate synthase activity
WP8S17E03_32870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S17E03_32880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP8S17E03_32900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP8S17E03_32910	COG3447	MASE1 domain protein
WP8S17E03_32910	COG5002	protein histidine kinase activity
WP8S17E03_32910	COG5001	Diguanylate cyclase
WP8S17E03_32920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP8S17E03_32990	COG0583	DNA-binding transcription factor activity
WP8S17E03_33000	COG1380	Effector of murein hydrolase LrgA
WP8S17E03_33010	COG1346	cytolysis
WP8S17E03_33020	COG0527	aspartate kinase activity
WP8S17E03_33020	COG0460	homoserine dehydrogenase
WP8S17E03_33030	COG0626	cystathionine gamma-synthase activity
WP8S17E03_33060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S17E03_33070	COG0814	amino acid
WP8S17E03_33080	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP8S17E03_33090	COG0494	nUDIX hydrolase
WP8S17E03_33100	COG1011	Hydrolase
WP8S17E03_33110	COG1902	pentaerythritol trinitrate reductase activity
WP8S17E03_33130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S17E03_33160	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP8S17E03_33180	COG3156	type II secretion system protein K
WP8S17E03_33190	COG4795	General secretion pathway protein
WP8S17E03_33200	COG2165	general secretion pathway protein
WP8S17E03_33220	COG2165	general secretion pathway protein
WP8S17E03_33230	COG1459	type II secretion system
WP8S17E03_33240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S17E03_33260	COG3031	protein transport across the cell outer membrane
WP8S17E03_33280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP8S17E03_33290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WP8S17E03_33320	COG0456	acetyltransferase
WP8S17E03_33330	COG3133	Outer membrane lipoprotein
WP8S17E03_33340	COG3025	triphosphatase activity
WP8S17E03_33350	COG1392	Phosphate transport regulator
WP8S17E03_33360	COG0306	phosphate transporter
WP8S17E03_33370	COG0617	tRNA 3'-terminal CCA addition
WP8S17E03_33380	COG3409	Peptidoglycan-binding domain 1 protein
WP8S17E03_33380	COG3267	Type II secretory pathway component ExeA
WP8S17E03_33400	COG1194	a g-specific adenine glycosylase
WP8S17E03_33410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP8S17E03_33440	COG3240	lipase activity
WP8S17E03_33460	COG3009	Protein conserved in bacteria
WP8S17E03_33470	COG3008	intermembrane lipid transfer
WP8S17E03_33470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S17E03_33480	COG2995	paraquat-inducible protein a
WP8S17E03_33500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S17E03_33510	COG2203	Gaf domain
WP8S17E03_33510	COG4251	negative regulation of phosphorylation
WP8S17E03_33510	COG3706	GGDEF domain
WP8S17E03_33510	COG5001	Diguanylate cyclase
WP8S17E03_33520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S17E03_33530	COG2813	Specifically methylates the guanine in position
WP8S17E03_33540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP8S17E03_33550	COG0297	glycogen (starch) synthase activity
WP8S17E03_33580	COG1757	Na H antiporter
WP8S17E03_33590	COG0583	DNA-binding transcription factor activity
WP8S17E03_33600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP8S17E03_33610	COG3842	ATPase activity
WP8S17E03_33620	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S17E03_33630	COG1177	transmembrane transport
WP8S17E03_33640	COG1012	belongs to the aldehyde dehydrogenase family
WP8S17E03_33650	COG0109	protoheme IX farnesyltransferase activity
WP8S17E03_33710	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WP8S17E03_33730	COG1565	acr, cog1565
WP8S17E03_33730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP8S17E03_33740	COG1444	tRNA N-acetyltransferase activity
WP8S17E03_33780	COG1803	Methylglyoxal synthase
WP8S17E03_33810	COG0252	asparaginase activity
WP8S17E03_33850	COG1263	PTS System
WP8S17E03_33850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S17E03_33860	COG0366	Alpha amylase catalytic
WP8S17E03_33870	COG0110	maltose O-acetyltransferase activity
WP8S17E03_33880	COG1522	sequence-specific DNA binding
WP8S17E03_33940	COG3068	Protein conserved in bacteria
WP8S17E03_33960	COG0739	heme binding
WP8S17E03_34000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP8S17E03_34010	COG1121	(ABC) transporter
WP8S17E03_34020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP8S17E03_34030	COG0583	DNA-binding transcription factor activity
WP8S17E03_34050	COG1573	uracil-dna glycosylase
WP8S17E03_34060	COG2962	Rard protein
WP8S17E03_34070	COG2827	Endonuclease containing a URI domain
WP8S17E03_34100	COG1842	Phage shock protein A
WP8S17E03_34110	COG0204	Acyl-transferase
WP8S17E03_34150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S17E03_34170	COG0484	heat shock protein binding
WP8S17E03_34310	COG1289	transmembrane transporter activity
WP8S17E03_34320	COG1566	PFAM secretion protein HlyD family protein
WP8S17E03_34350	COG1051	belongs to the nudix hydrolase family
WP8S17E03_34360	COG3150	esterase
WP8S17E03_34380	COG3151	Protein conserved in bacteria
WP8S17E03_34390	COG0494	nUDIX hydrolase
WP8S17E03_34400	COG1538	Outer membrane efflux protein
WP8S17E03_34410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP8S17E03_34410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP8S17E03_34420	COG1560	Kdo2-lipid A biosynthetic process
WP8S17E03_34450	COG2771	luxR family
WP8S17E03_34460	COG3916	Acyl-homoserine-lactone synthase
WP8S17E03_34480	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP8S17E03_34490	COG2213	PTS system mannitol-specific
WP8S17E03_34490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S17E03_34500	COG0246	Mannitol dehydrogenase
WP8S17E03_34510	COG3722	fumarate hydratase activity
WP8S17E03_34520	COG3263	regulation of cellular component size
WP8S17E03_34560	COG1671	Belongs to the UPF0178 family
WP8S17E03_34590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S17E03_34600	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_34640	COG1575	Belongs to the MenA family. Type 1 subfamily
WP8S17E03_34650	COG1169	isochorismate synthase
WP8S17E03_34660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP8S17E03_34670	COG0596	Alpha beta hydrolase
WP8S17E03_34680	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP8S17E03_34700	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S17E03_34710	COG3291	Pkd domain containing protein
WP8S17E03_34720	COG2949	membrane
WP8S17E03_34730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP8S17E03_34750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8S17E03_34810	COG2873	o-acetylhomoserine
WP8S17E03_34830	COG1979	alcohol dehydrogenase
WP8S17E03_34860	COG4221	oxidoreductase activity
WP8S17E03_34900	COG1285	pathogenesis
WP8S17E03_34930	COG1368	sulfuric ester hydrolase activity
WP8S17E03_34940	COG1522	sequence-specific DNA binding
WP8S17E03_34960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP8S17E03_34980	COG1546	Belongs to the CinA family
WP8S17E03_34980	COG1058	Belongs to the CinA family
WP8S17E03_34990	COG1988	membrane-bound metal-dependent
WP8S17E03_35010	COG0561	phosphatase activity
WP8S17E03_35020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP8S17E03_35040	COG1011	Hydrolase
WP8S17E03_35070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP8S17E03_35080	COG0019	diaminopimelate decarboxylase activity
WP8S17E03_35090	COG1965	Belongs to the frataxin family
WP8S17E03_35100	COG0400	carboxylic ester hydrolase activity
WP8S17E03_35110	COG3072	Adenylate cyclase
WP8S17E03_35120	COG0181	hydroxymethylbilane synthase activity
WP8S17E03_35140	COG2959	enzyme of heme biosynthesis
WP8S17E03_35150	COG3071	HemY protein
WP8S17E03_35170	COG0312	modulator of DNA gyrase
WP8S17E03_35180	COG3028	Belongs to the UPF0307 family
WP8S17E03_35200	COG2926	Belongs to the UPF0265 family
WP8S17E03_35230	COG1396	sequence-specific DNA binding
WP8S17E03_35240	COG3135	benzoate transporter
WP8S17E03_35300	COG3047	cAMP biosynthetic process
WP8S17E03_35320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP8S17E03_35330	COG2197	response regulator
WP8S17E03_35400	COG1278	Cold shock
WP8S17E03_35410	COG2205	protein histidine kinase activity
WP8S17E03_35420	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_35460	COG3706	GGDEF domain
WP8S17E03_35470	COG0347	Belongs to the P(II) protein family
WP8S17E03_35480	COG0004	ammonium transporteR
WP8S17E03_35500	COG0346	lactoylglutathione lyase activity
WP8S17E03_35520	COG3039	Transposase
WP8S17E03_35530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8S17E03_35540	COG1074	ATP-dependent DNA helicase activity
WP8S17E03_35550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP8S17E03_35560	COG2259	Doxx family
WP8S17E03_35570	COG1741	Belongs to the pirin family
WP8S17E03_35590	COG0583	DNA-binding transcription factor activity
WP8S17E03_35650	COG1175	transmembrane transport
WP8S17E03_35670	COG3842	ATPase activity
WP8S17E03_35730	COG0456	acetyltransferase
WP8S17E03_35740	COG0753	catalase activity
WP8S17E03_35780	COG0494	nUDIX hydrolase
WP8S17E03_35790	COG0628	permease
WP8S17E03_35810	COG2957	Belongs to the agmatine deiminase family
WP8S17E03_35840	COG2957	Belongs to the agmatine deiminase family
WP8S17E03_35850	COG0583	DNA-binding transcription factor activity
WP8S17E03_35880	COG1461	Dihydroxyacetone kinase
WP8S17E03_35890	COG2376	Dihydroxyacetone kinase
WP8S17E03_35900	COG2252	PERMEase
WP8S17E03_35910	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WP8S17E03_35920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S17E03_35930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S17E03_35940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP8S17E03_35950	COG0049	tRNA binding
WP8S17E03_35960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP8S17E03_35970	COG2168	tRNA wobble position uridine thiolation
WP8S17E03_35990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S17E03_36000	COG0251	oxidation-reduction process
WP8S17E03_36010	COG2964	Protein conserved in bacteria
WP8S17E03_36020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP8S17E03_36030	COG0085	RNA polymerase activity
WP8S17E03_36040	COG0222	ribosome binding
WP8S17E03_36050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP8S17E03_36060	COG0081	regulation of translation
WP8S17E03_36070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP8S17E03_36080	COG0250	Participates in transcription elongation, termination and antitermination
WP8S17E03_36100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S17E03_36130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP8S17E03_36140	COG0569	domain protein
WP8S17E03_36150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S17E03_36160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP8S17E03_36170	COG3005	denitrification pathway
WP8S17E03_36190	COG0243	molybdopterin cofactor binding
WP8S17E03_36220	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_36260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP8S17E03_36290	COG2204	response regulator
WP8S17E03_36310	COG2205	protein histidine kinase activity
WP8S17E03_36350	COG0517	IMP dehydrogenase activity
WP8S17E03_36350	COG0516	GMP reductase activity
WP8S17E03_36370	COG1522	sequence-specific DNA binding
WP8S17E03_36380	COG2502	aspartate--ammonia ligase
WP8S17E03_36410	COG0583	DNA-binding transcription factor activity
WP8S17E03_36420	COG0542	response to heat
WP8S17E03_36440	COG0564	pseudouridine synthase activity
WP8S17E03_36450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S17E03_36460	COG3681	Belongs to the UPF0597 family
WP8S17E03_36470	COG2964	Protein conserved in bacteria
WP8S17E03_36480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP8S17E03_36490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP8S17E03_36500	COG1979	alcohol dehydrogenase
WP8S17E03_36510	COG2207	Transcriptional regulator
WP8S17E03_36520	COG3040	lipid binding
WP8S17E03_36540	COG0840	transmembrane signaling receptor activity
WP8S17E03_36560	COG0583	DNA-binding transcription factor activity
WP8S17E03_36590	COG0540	Belongs to the ATCase OTCase family
WP8S17E03_36600	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP8S17E03_36610	COG1438	arginine binding
WP8S17E03_36620	COG1288	antiporter activity
WP8S17E03_36630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8S17E03_36710	COG3250	beta-galactosidase activity
WP8S17E03_36720	COG1609	Transcriptional regulator
WP8S17E03_36730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S17E03_36750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8S17E03_36760	COG2017	converts alpha-aldose to the beta-anomer
WP8S17E03_36770	COG0667	Aldo Keto reductase
WP8S17E03_36780	COG1968	undecaprenyl-diphosphatase activity
WP8S17E03_36790	COG3806	Anti-sigma factor
WP8S17E03_36800	COG1595	DNA-templated transcription, initiation
WP8S17E03_36840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP8S17E03_36850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP8S17E03_36860	COG0477	Major facilitator Superfamily
WP8S17E03_36890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S17E03_36900	COG1131	(ABC) transporter
WP8S17E03_36910	COG0842	Transport permease protein
WP8S17E03_36920	COG0842	Transport permease protein
WP8S17E03_36930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S17E03_36960	COG2116	formate transmembrane transporter activity
WP8S17E03_36970	COG1648	precorrin-2 dehydrogenase activity
WP8S17E03_36970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S17E03_36980	COG2239	Acts as a magnesium transporter
WP8S17E03_36990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S17E03_37000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP8S17E03_37020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP8S17E03_37040	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S17E03_37050	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S17E03_37070	COG2258	MOSC domain
WP8S17E03_37080	COG1177	transmembrane transport
WP8S17E03_37090	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S17E03_37100	COG3842	ATPase activity
WP8S17E03_37140	COG0174	glutamine synthetase
WP8S17E03_37180	COG3045	CreA protein
WP8S17E03_37190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S17E03_37200	COG0443	Heat shock 70 kDa protein
WP8S17E03_37230	COG0366	Alpha amylase catalytic
WP8S17E03_37260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S17E03_37270	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_37280	COG2205	protein histidine kinase activity
WP8S17E03_37300	COG0281	malic enzyme
WP8S17E03_37310	COG0702	epimerase
WP8S17E03_37320	COG0254	rRNA binding
WP8S17E03_37330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP8S17E03_37370	COG0129	dihydroxy-acid dehydratase activity
WP8S17E03_37390	COG3978	acetolactate synthase activity
WP8S17E03_37410	COG0606	chelatase, subunit chli
WP8S17E03_37420	COG0204	Acyl-transferase
WP8S17E03_37430	COG0204	Acyl-transferase
WP8S17E03_37440	COG1683	Conserved Protein
WP8S17E03_37460	COG1335	isochorismatase
WP8S17E03_37480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8S17E03_37490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP8S17E03_37510	COG3084	Protein conserved in bacteria
WP8S17E03_37520	COG5001	Diguanylate cyclase
WP8S17E03_37520	COG4251	negative regulation of phosphorylation
WP8S17E03_37520	COG3706	GGDEF domain
WP8S17E03_37520	COG2203	Gaf domain
WP8S17E03_37560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP8S17E03_37570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP8S17E03_37580	COG1561	YicC-like family, N-terminal region
WP8S17E03_37600	COG1519	Transferase
WP8S17E03_37610	COG0859	PFAM glycosyl transferase family 9
WP8S17E03_37620	COG0463	Glycosyl transferase, family 2
WP8S17E03_37630	COG0859	PFAM glycosyl transferase family 9
WP8S17E03_37640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP8S17E03_37650	COG2990	Protein conserved in bacteria
WP8S17E03_37660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP8S17E03_37680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP8S17E03_37690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP8S17E03_37700	COG2003	Belongs to the UPF0758 family
WP8S17E03_37710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP8S17E03_37720	COG0756	dUTP diphosphatase activity
WP8S17E03_37730	COG1309	transcriptional regulator
WP8S17E03_37740	COG0668	transmembrane transport
WP8S17E03_37760	COG0166	Belongs to the GPI family
WP8S17E03_37770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP8S17E03_37780	COG0583	DNA-binding transcription factor activity
WP8S17E03_37800	COG1042	CoA-binding domain protein
WP8S17E03_37800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S17E03_37800	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S17E03_37820	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP8S17E03_37830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S17E03_37840	COG1739	Uncharacterized protein family UPF0029
WP8S17E03_37850	COG0006	proline dipeptidase activity
WP8S17E03_37860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S17E03_37870	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S17E03_37870	COG1024	Enoyl-CoA hydratase
WP8S17E03_37880	COG0183	Belongs to the thiolase family
WP8S17E03_37890	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_37910	COG1653	transport
WP8S17E03_37930	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S17E03_37940	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S17E03_37950	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S17E03_37960	COG0251	oxidation-reduction process
WP8S17E03_37970	COG2885	chlorophyll binding
WP8S17E03_37990	COG1335	isochorismatase
WP8S17E03_38000	COG2818	Glycosylase
WP8S17E03_38010	COG0752	glycyl-tRNA synthetase alpha subunit
WP8S17E03_38020	COG0751	glycine-tRNA ligase activity
WP8S17E03_38030	COG3706	GGDEF domain
WP8S17E03_38030	COG2203	Gaf domain
WP8S17E03_38030	COG4251	negative regulation of phosphorylation
WP8S17E03_38030	COG5001	Diguanylate cyclase
WP8S17E03_38060	COG0814	amino acid
WP8S17E03_38070	COG0814	amino acid
WP8S17E03_38080	COG3033	Beta-eliminating lyase
WP8S17E03_38090	COG0348	domain, Protein
WP8S17E03_38110	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S17E03_38120	COG0426	domain, Protein
WP8S17E03_38120	COG1773	rubredoxin
WP8S17E03_38130	COG3604	Transcriptional regulator
WP8S17E03_38140	COG1609	Transcriptional regulator
WP8S17E03_38220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S17E03_38250	COG2960	long-chain fatty acid transporting porin activity
WP8S17E03_38270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP8S17E03_38300	COG3118	belongs to the thioredoxin family
WP8S17E03_38310	COG0513	Belongs to the DEAD box helicase family
WP8S17E03_38320	COG0248	Ppx GppA phosphatase
WP8S17E03_38340	COG0742	ribosomal rna small subunit methyltransferase
WP8S17E03_38380	COG0084	hydrolase, TatD family'
WP8S17E03_38390	COG0805	protein transport
WP8S17E03_38400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S17E03_38410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S17E03_38420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP8S17E03_38430	COG3165	ubiquinone biosynthetic process from chorismate
WP8S17E03_38450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP8S17E03_38460	COG0402	S-adenosylhomocysteine deaminase activity
WP8S17E03_38470	COG3335	DDE superfamily endonuclease
WP8S17E03_38510	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP8S17E03_38520	COG0848	biopolymer transport protein
WP8S17E03_38530	COG0811	peptide transport
WP8S17E03_38540	COG0811	peptide transport
WP8S17E03_38560	COG2771	luxR family
WP8S17E03_38570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP8S17E03_38580	COG1349	DNA-binding transcription factor activity
WP8S17E03_38590	COG0745	RESPONSE REGULATOR receiver
WP8S17E03_38600	COG2205	protein histidine kinase activity
WP8S17E03_38620	COG4452	Inner membrane protein CreD
WP8S17E03_38630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP8S17E03_38640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP8S17E03_38650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP8S17E03_38660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP8S17E03_38670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP8S17E03_38680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP8S17E03_38690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP8S17E03_38710	COG0356	it plays a direct role in the translocation of protons across the membrane
WP8S17E03_38730	COG1475	DNA binding
WP8S17E03_38740	COG1192	Involved in chromosome partitioning
WP8S17E03_38750	COG0357	Ribosomal RNA small subunit methyltransferase G
WP8S17E03_38760	COG0445	tRNA wobble uridine modification
WP8S17E03_38770	COG0716	FMN binding
WP8S17E03_38780	COG4774	siderophore transport
WP8S17E03_38790	COG4615	Cyclic peptide transporter
WP8S17E03_38800	COG1120	ATPase activity
WP8S17E03_38810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8S17E03_38830	COG3550	peptidyl-serine autophosphorylation
WP8S17E03_38860	COG2801	Transposase and inactivated derivatives
WP8S17E03_38880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP8S17E03_38890	COG0706	membrane insertase activity
WP8S17E03_38900	COG0594	ribonuclease P activity
WP8S17E03_38910	COG0230	Belongs to the bacterial ribosomal protein bL34 family