locus-tag	class	description
WP8S18E04_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP8S18E04_00020	COG0592	DNA-directed DNA polymerase activity
WP8S18E04_00040	COG0187	DNA topoisomerase II activity
WP8S18E04_00050	COG2207	Transcriptional regulator
WP8S18E04_00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP8S18E04_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S18E04_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S18E04_00090	COG3977	Valine--pyruvate aminotransferase
WP8S18E04_00130	COG2814	Major facilitator Superfamily
WP8S18E04_00140	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_00150	COG2205	protein histidine kinase activity
WP8S18E04_00190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S18E04_00200	COG4191	Histidine kinase
WP8S18E04_00200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_00210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_00230	COG1309	transcriptional regulator
WP8S18E04_00250	COG0561	phosphatase activity
WP8S18E04_00260	COG2267	carboxylic ester hydrolase activity
WP8S18E04_00270	COG0110	maltose O-acetyltransferase activity
WP8S18E04_00280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S18E04_00290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S18E04_00300	COG1758	RNA polymerase activity
WP8S18E04_00320	COG0859	PFAM glycosyl transferase family 9
WP8S18E04_00330	COG3642	lipopolysaccharide core region biosynthetic process
WP8S18E04_00410	COG0589	response to stress
WP8S18E04_00420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8S18E04_00430	COG3706	GGDEF domain
WP8S18E04_00440	COG1528	Iron-storage protein
WP8S18E04_00450	COG2081	HI0933 family
WP8S18E04_00460	COG2223	nitrite transmembrane transporter activity
WP8S18E04_00470	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_00520	COG3039	Transposase
WP8S18E04_00530	COG2205	protein histidine kinase activity
WP8S18E04_00530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_00540	COG2205	protein histidine kinase activity
WP8S18E04_00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_00560	COG3275	phosphorelay sensor kinase activity
WP8S18E04_00570	COG3279	Response regulator of the LytR AlgR family
WP8S18E04_00580	COG2223	nitrite transmembrane transporter activity
WP8S18E04_00590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP8S18E04_00600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP8S18E04_00650	COG1042	CoA-binding domain protein
WP8S18E04_00650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E04_00650	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S18E04_00670	COG0583	DNA-binding transcription factor activity
WP8S18E04_00680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP8S18E04_00690	COG0166	Belongs to the GPI family
WP8S18E04_00710	COG0668	transmembrane transport
WP8S18E04_00720	COG1309	transcriptional regulator
WP8S18E04_00730	COG0756	dUTP diphosphatase activity
WP8S18E04_00740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP8S18E04_00750	COG2003	Belongs to the UPF0758 family
WP8S18E04_00760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP8S18E04_00770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP8S18E04_00790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP8S18E04_00800	COG2990	Protein conserved in bacteria
WP8S18E04_00810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP8S18E04_00820	COG0859	PFAM glycosyl transferase family 9
WP8S18E04_00830	COG0463	Glycosyl transferase, family 2
WP8S18E04_00840	COG0859	PFAM glycosyl transferase family 9
WP8S18E04_00850	COG1519	Transferase
WP8S18E04_00870	COG1561	YicC-like family, N-terminal region
WP8S18E04_00880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP8S18E04_00890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP8S18E04_00920	COG2203	Gaf domain
WP8S18E04_00920	COG5001	Diguanylate cyclase
WP8S18E04_00920	COG3706	GGDEF domain
WP8S18E04_00920	COG4251	negative regulation of phosphorylation
WP8S18E04_00930	COG3084	Protein conserved in bacteria
WP8S18E04_00950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP8S18E04_00960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8S18E04_00970	COG3639	organic phosphonate transmembrane transporter activity
WP8S18E04_00980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WP8S18E04_00990	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
WP8S18E04_01010	COG1335	isochorismatase
WP8S18E04_01030	COG1683	Conserved Protein
WP8S18E04_01040	COG0204	Acyl-transferase
WP8S18E04_01050	COG0204	Acyl-transferase
WP8S18E04_01060	COG0606	chelatase, subunit chli
WP8S18E04_01080	COG3978	acetolactate synthase activity
WP8S18E04_01100	COG0129	dihydroxy-acid dehydratase activity
WP8S18E04_01140	COG1309	transcriptional regulator
WP8S18E04_01150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP8S18E04_01160	COG0254	rRNA binding
WP8S18E04_01180	COG0702	epimerase
WP8S18E04_01190	COG0281	malic enzyme
WP8S18E04_01210	COG2205	protein histidine kinase activity
WP8S18E04_01220	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_01230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E04_01260	COG0366	Alpha amylase catalytic
WP8S18E04_01290	COG0443	Heat shock 70 kDa protein
WP8S18E04_01300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S18E04_01310	COG3045	CreA protein
WP8S18E04_01350	COG0174	glutamine synthetase
WP8S18E04_01390	COG3842	ATPase activity
WP8S18E04_01400	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S18E04_01410	COG1177	transmembrane transport
WP8S18E04_01420	COG2258	MOSC domain
WP8S18E04_01440	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S18E04_01450	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E04_01470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP8S18E04_01550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP8S18E04_01560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S18E04_01570	COG2239	Acts as a magnesium transporter
WP8S18E04_01580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E04_01580	COG1648	precorrin-2 dehydrogenase activity
WP8S18E04_01590	COG2116	formate transmembrane transporter activity
WP8S18E04_01620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E04_01630	COG0842	Transport permease protein
WP8S18E04_01640	COG0842	Transport permease protein
WP8S18E04_01650	COG1131	(ABC) transporter
WP8S18E04_01660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_01690	COG0477	Major facilitator Superfamily
WP8S18E04_01700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP8S18E04_01710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP8S18E04_01750	COG1595	DNA-templated transcription, initiation
WP8S18E04_01760	COG3806	Anti-sigma factor
WP8S18E04_01770	COG1968	undecaprenyl-diphosphatase activity
WP8S18E04_01780	COG0667	Aldo Keto reductase
WP8S18E04_01790	COG2017	converts alpha-aldose to the beta-anomer
WP8S18E04_01800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8S18E04_01820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E04_01830	COG1609	Transcriptional regulator
WP8S18E04_01840	COG3250	beta-galactosidase activity
WP8S18E04_01920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8S18E04_01930	COG1288	antiporter activity
WP8S18E04_01940	COG1438	arginine binding
WP8S18E04_01950	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP8S18E04_01960	COG0540	Belongs to the ATCase OTCase family
WP8S18E04_02000	COG0840	transmembrane signaling receptor activity
WP8S18E04_02020	COG3040	lipid binding
WP8S18E04_02030	COG2207	Transcriptional regulator
WP8S18E04_02040	COG1979	alcohol dehydrogenase
WP8S18E04_02050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP8S18E04_02060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP8S18E04_02070	COG2964	Protein conserved in bacteria
WP8S18E04_02080	COG3681	Belongs to the UPF0597 family
WP8S18E04_02090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E04_02100	COG0564	pseudouridine synthase activity
WP8S18E04_02120	COG0542	response to heat
WP8S18E04_02130	COG0583	DNA-binding transcription factor activity
WP8S18E04_02160	COG2502	aspartate--ammonia ligase
WP8S18E04_02170	COG1522	sequence-specific DNA binding
WP8S18E04_02190	COG0517	IMP dehydrogenase activity
WP8S18E04_02190	COG0516	GMP reductase activity
WP8S18E04_02230	COG2205	protein histidine kinase activity
WP8S18E04_02250	COG2204	response regulator
WP8S18E04_02280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP8S18E04_02320	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_02350	COG0243	molybdopterin cofactor binding
WP8S18E04_02360	COG3005	denitrification pathway
WP8S18E04_02370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP8S18E04_02380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E04_02390	COG0569	domain protein
WP8S18E04_02400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP8S18E04_02430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S18E04_02450	COG0250	Participates in transcription elongation, termination and antitermination
WP8S18E04_02460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP8S18E04_02470	COG0081	regulation of translation
WP8S18E04_02480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP8S18E04_02490	COG0222	ribosome binding
WP8S18E04_02500	COG0085	RNA polymerase activity
WP8S18E04_02510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP8S18E04_02520	COG2964	Protein conserved in bacteria
WP8S18E04_02530	COG0251	oxidation-reduction process
WP8S18E04_02540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S18E04_02560	COG2168	tRNA wobble position uridine thiolation
WP8S18E04_02570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP8S18E04_02580	COG0049	tRNA binding
WP8S18E04_02590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP8S18E04_02600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S18E04_02610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S18E04_02620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WP8S18E04_02630	COG2252	PERMEase
WP8S18E04_02640	COG2376	Dihydroxyacetone kinase
WP8S18E04_02650	COG1461	Dihydroxyacetone kinase
WP8S18E04_02680	COG0583	DNA-binding transcription factor activity
WP8S18E04_02690	COG2957	Belongs to the agmatine deiminase family
WP8S18E04_02720	COG2957	Belongs to the agmatine deiminase family
WP8S18E04_02740	COG0628	permease
WP8S18E04_02750	COG0494	nUDIX hydrolase
WP8S18E04_02810	COG0753	catalase activity
WP8S18E04_02820	COG0456	acetyltransferase
WP8S18E04_02880	COG3842	ATPase activity
WP8S18E04_02900	COG1175	transmembrane transport
WP8S18E04_02960	COG0583	DNA-binding transcription factor activity
WP8S18E04_02980	COG1741	Belongs to the pirin family
WP8S18E04_02990	COG2259	Doxx family
WP8S18E04_03000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP8S18E04_03010	COG1074	ATP-dependent DNA helicase activity
WP8S18E04_03020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8S18E04_03040	COG0004	ammonium transporteR
WP8S18E04_03050	COG0347	Belongs to the P(II) protein family
WP8S18E04_03060	COG3706	GGDEF domain
WP8S18E04_03100	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_03110	COG2205	protein histidine kinase activity
WP8S18E04_03120	COG1278	Cold shock
WP8S18E04_03190	COG2801	Transposase and inactivated derivatives
WP8S18E04_03210	COG2197	response regulator
WP8S18E04_03220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP8S18E04_03230	COG3047	cAMP biosynthetic process
WP8S18E04_03290	COG3135	benzoate transporter
WP8S18E04_03300	COG1396	sequence-specific DNA binding
WP8S18E04_03330	COG2926	Belongs to the UPF0265 family
WP8S18E04_03350	COG3028	Belongs to the UPF0307 family
WP8S18E04_03360	COG0312	modulator of DNA gyrase
WP8S18E04_03380	COG3071	HemY protein
WP8S18E04_03390	COG2959	enzyme of heme biosynthesis
WP8S18E04_03410	COG0181	hydroxymethylbilane synthase activity
WP8S18E04_03420	COG3072	Adenylate cyclase
WP8S18E04_03430	COG0400	carboxylic ester hydrolase activity
WP8S18E04_03440	COG1965	Belongs to the frataxin family
WP8S18E04_03450	COG0019	diaminopimelate decarboxylase activity
WP8S18E04_03460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP8S18E04_03490	COG1011	Hydrolase
WP8S18E04_03510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP8S18E04_03520	COG0561	phosphatase activity
WP8S18E04_03550	COG1988	membrane-bound metal-dependent
WP8S18E04_03560	COG1058	Belongs to the CinA family
WP8S18E04_03560	COG1546	Belongs to the CinA family
WP8S18E04_03580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP8S18E04_03600	COG1522	sequence-specific DNA binding
WP8S18E04_03610	COG1368	sulfuric ester hydrolase activity
WP8S18E04_03640	COG1285	pathogenesis
WP8S18E04_03680	COG4221	oxidoreductase activity
WP8S18E04_03710	COG1979	alcohol dehydrogenase
WP8S18E04_03730	COG2873	o-acetylhomoserine
WP8S18E04_03790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8S18E04_03810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP8S18E04_03820	COG2949	membrane
WP8S18E04_03830	COG3291	Pkd domain containing protein
WP8S18E04_03840	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E04_03860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP8S18E04_03870	COG0596	Alpha beta hydrolase
WP8S18E04_03880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP8S18E04_03890	COG1169	isochorismate synthase
WP8S18E04_03900	COG1575	Belongs to the MenA family. Type 1 subfamily
WP8S18E04_03940	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_03950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E04_03990	COG1671	Belongs to the UPF0178 family
WP8S18E04_04030	COG3263	regulation of cellular component size
WP8S18E04_04040	COG3722	fumarate hydratase activity
WP8S18E04_04050	COG0246	Mannitol dehydrogenase
WP8S18E04_04060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_04060	COG2213	PTS system mannitol-specific
WP8S18E04_04070	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP8S18E04_04090	COG3916	Acyl-homoserine-lactone synthase
WP8S18E04_04100	COG2771	luxR family
WP8S18E04_04130	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E04_04140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP8S18E04_04140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP8S18E04_04150	COG1538	Outer membrane efflux protein
WP8S18E04_04160	COG0494	nUDIX hydrolase
WP8S18E04_04170	COG3151	Protein conserved in bacteria
WP8S18E04_04190	COG3150	esterase
WP8S18E04_04200	COG1051	belongs to the nudix hydrolase family
WP8S18E04_04230	COG1566	PFAM secretion protein HlyD family protein
WP8S18E04_04240	COG1289	transmembrane transporter activity
WP8S18E04_04340	COG0484	heat shock protein binding
WP8S18E04_04360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S18E04_04400	COG0204	Acyl-transferase
WP8S18E04_04410	COG1842	Phage shock protein A
WP8S18E04_04440	COG2827	Endonuclease containing a URI domain
WP8S18E04_04450	COG2962	Rard protein
WP8S18E04_04460	COG1573	uracil-dna glycosylase
WP8S18E04_04480	COG0583	DNA-binding transcription factor activity
WP8S18E04_04490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP8S18E04_04500	COG1121	(ABC) transporter
WP8S18E04_04510	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP8S18E04_04550	COG0739	heme binding
WP8S18E04_04570	COG3068	Protein conserved in bacteria
WP8S18E04_04630	COG1522	sequence-specific DNA binding
WP8S18E04_04640	COG0110	maltose O-acetyltransferase activity
WP8S18E04_04650	COG0366	Alpha amylase catalytic
WP8S18E04_04660	COG1263	PTS System
WP8S18E04_04660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_04700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E04_04710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E04_04720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E04_04730	COG2723	6-phospho-beta-galactosidase activity
WP8S18E04_04740	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP8S18E04_04750	COG1940	carbohydrate kinase activity
WP8S18E04_04800	COG1609	Transcriptional regulator
WP8S18E04_04820	COG0252	asparaginase activity
WP8S18E04_04860	COG1803	Methylglyoxal synthase
WP8S18E04_04900	COG1444	tRNA N-acetyltransferase activity
WP8S18E04_04910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP8S18E04_04910	COG1565	acr, cog1565
WP8S18E04_04930	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WP8S18E04_04990	COG0109	protoheme IX farnesyltransferase activity
WP8S18E04_05000	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_05010	COG1177	transmembrane transport
WP8S18E04_05020	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S18E04_05030	COG3842	ATPase activity
WP8S18E04_05040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP8S18E04_05060	COG0583	DNA-binding transcription factor activity
WP8S18E04_05070	COG1757	Na H antiporter
WP8S18E04_05100	COG0297	glycogen (starch) synthase activity
WP8S18E04_05110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP8S18E04_05120	COG2813	Specifically methylates the guanine in position
WP8S18E04_05130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S18E04_05140	COG5001	Diguanylate cyclase
WP8S18E04_05140	COG4251	negative regulation of phosphorylation
WP8S18E04_05140	COG3706	GGDEF domain
WP8S18E04_05140	COG2203	Gaf domain
WP8S18E04_05150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E04_05170	COG2995	paraquat-inducible protein a
WP8S18E04_05180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S18E04_05180	COG3008	intermembrane lipid transfer
WP8S18E04_05190	COG3009	Protein conserved in bacteria
WP8S18E04_05210	COG3240	lipase activity
WP8S18E04_05220	COG3240	lipase activity
WP8S18E04_05250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP8S18E04_05260	COG1194	a g-specific adenine glycosylase
WP8S18E04_05280	COG3409	Peptidoglycan-binding domain 1 protein
WP8S18E04_05280	COG3267	Type II secretory pathway component ExeA
WP8S18E04_05290	COG0617	tRNA 3'-terminal CCA addition
WP8S18E04_05320	COG0306	phosphate transporter
WP8S18E04_05330	COG1392	Phosphate transport regulator
WP8S18E04_05340	COG3025	triphosphatase activity
WP8S18E04_05350	COG3133	Outer membrane lipoprotein
WP8S18E04_05360	COG0456	acetyltransferase
WP8S18E04_05390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WP8S18E04_05400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP8S18E04_05420	COG3031	protein transport across the cell outer membrane
WP8S18E04_05440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S18E04_05450	COG1459	type II secretion system
WP8S18E04_05460	COG2165	general secretion pathway protein
WP8S18E04_05480	COG2165	general secretion pathway protein
WP8S18E04_05490	COG4795	General secretion pathway protein
WP8S18E04_05500	COG3156	type II secretion system protein K
WP8S18E04_05520	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP8S18E04_05550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S18E04_05570	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E04_05580	COG1011	Hydrolase
WP8S18E04_05590	COG0494	nUDIX hydrolase
WP8S18E04_05600	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP8S18E04_05610	COG0814	amino acid
WP8S18E04_05620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E04_05650	COG0626	cystathionine gamma-synthase activity
WP8S18E04_05660	COG0460	homoserine dehydrogenase
WP8S18E04_05660	COG0527	aspartate kinase activity
WP8S18E04_05670	COG1346	cytolysis
WP8S18E04_05680	COG1380	Effector of murein hydrolase LrgA
WP8S18E04_05690	COG0583	DNA-binding transcription factor activity
WP8S18E04_05760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP8S18E04_05770	COG3447	MASE1 domain protein
WP8S18E04_05770	COG5002	protein histidine kinase activity
WP8S18E04_05770	COG5001	Diguanylate cyclase
WP8S18E04_05790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP8S18E04_05810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP8S18E04_05820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S18E04_05840	COG0137	argininosuccinate synthase activity
WP8S18E04_05850	COG0165	Argininosuccinate lyase
WP8S18E04_05860	COG0583	DNA-binding transcription factor activity
WP8S18E04_05880	COG1942	4-Oxalocrotonate Tautomerase
WP8S18E04_05940	COG0110	maltose O-acetyltransferase activity
WP8S18E04_05950	COG3174	membrane
WP8S18E04_05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_05970	COG1126	abc transporter atp-binding protein
WP8S18E04_05980	COG0765	amino acid transport
WP8S18E04_06000	COG0765	amino acid transport
WP8S18E04_06010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S18E04_06020	COG1505	serine-type exopeptidase activity
WP8S18E04_06040	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_06050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP8S18E04_06080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S18E04_06090	COG4991	sh3 domain protein
WP8S18E04_06100	COG2816	NAD+ diphosphatase activity
WP8S18E04_06110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP8S18E04_06120	COG1940	carbohydrate kinase activity
WP8S18E04_06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S18E04_06140	COG0126	phosphoglycerate kinase activity
WP8S18E04_06160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E04_06220	COG0583	DNA-binding transcription factor activity
WP8S18E04_06230	COG0354	folic acid binding
WP8S18E04_06240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP8S18E04_06260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP8S18E04_06270	COG1595	DNA-templated transcription, initiation
WP8S18E04_06310	COG0481	GTPase activity
WP8S18E04_06320	COG0681	Belongs to the peptidase S26 family
WP8S18E04_06330	COG0571	ribonuclease III activity
WP8S18E04_06350	COG1381	Involved in DNA repair and RecF pathway recombination
WP8S18E04_06360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP8S18E04_06370	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP8S18E04_06380	COG4807	Protein conserved in bacteria
WP8S18E04_06400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E04_06410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S18E04_06420	COG3956	TIGRFAM MazG family protein
WP8S18E04_06430	COG0504	CTP synthase activity
WP8S18E04_06440	COG0148	phosphopyruvate hydratase activity
WP8S18E04_06450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP8S18E04_06460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP8S18E04_06480	COG0585	pseudouridine synthase activity
WP8S18E04_06490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP8S18E04_06500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP8S18E04_06510	COG1238	metal cluster binding
WP8S18E04_06520	COG4942	peptidase
WP8S18E04_06520	COG1388	LysM domain
WP8S18E04_06540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP8S18E04_06550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP8S18E04_06560	COG1610	YqeY-like protein
WP8S18E04_06570	COG0358	DNA primase activity
WP8S18E04_06580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP8S18E04_06640	COG0138	bifunctional purine biosynthesis protein purh
WP8S18E04_06670	COG3036	rescue of stalled ribosome
WP8S18E04_06680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8S18E04_06690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP8S18E04_06710	COG0673	inositol 2-dehydrogenase activity
WP8S18E04_06730	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP8S18E04_06740	COG0330	HflC and HflK could
WP8S18E04_06750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E04_06750	COG1648	precorrin-2 dehydrogenase activity
WP8S18E04_06760	COG0175	sulfate reduction
WP8S18E04_06770	COG2895	sulfate adenylyltransferase (ATP) activity
WP8S18E04_06780	COG0471	metal ion transport
WP8S18E04_06780	COG3273	potassium ion transport
WP8S18E04_06790	COG0529	Catalyzes the synthesis of activated sulfate
WP8S18E04_06880	COG1136	(ABC) transporter
WP8S18E04_06910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP8S18E04_06940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP8S18E04_06950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S18E04_06960	COG0163	prenyltransferase activity
WP8S18E04_06990	COG1131	(ABC) transporter
WP8S18E04_07000	COG0842	Transport permease protein
WP8S18E04_07040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP8S18E04_07050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP8S18E04_07060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP8S18E04_07080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E04_07090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP8S18E04_07100	COG1489	DNA binding
WP8S18E04_07120	COG1643	Atp-dependent helicase
WP8S18E04_07130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S18E04_07140	COG0346	lactoylglutathione lyase activity
WP8S18E04_07160	COG2076	Multidrug Resistance protein
WP8S18E04_07170	COG0583	DNA-binding transcription factor activity
WP8S18E04_07190	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E04_07220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP8S18E04_07230	COG0038	chloride channel
WP8S18E04_07250	COG0316	Belongs to the HesB IscA family
WP8S18E04_07260	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_07270	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP8S18E04_07280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E04_07300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_07360	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_07370	COG3104	oligopeptide transport
WP8S18E04_07380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP8S18E04_07390	COG1555	photosystem II stabilization
WP8S18E04_07410	COG2350	Protein conserved in bacteria
WP8S18E04_07420	COG2917	probably involved in intracellular septation
WP8S18E04_07430	COG0076	glutamate decarboxylase activity
WP8S18E04_07440	COG1272	protein, Hemolysin III
WP8S18E04_07450	COG2985	domain, Protein
WP8S18E04_07450	COG0569	domain protein
WP8S18E04_07470	COG0477	Major facilitator Superfamily
WP8S18E04_07480	COG0583	DNA-binding transcription factor activity
WP8S18E04_07490	COG3227	Zinc metalloprotease (Elastase)
WP8S18E04_07500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E04_07510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E04_07530	COG2731	YhcH YjgK YiaL family protein
WP8S18E04_07550	COG0668	transmembrane transport
WP8S18E04_07570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S18E04_07590	COG0789	Transcriptional regulator
WP8S18E04_07600	COG2801	Transposase and inactivated derivatives
WP8S18E04_07710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP8S18E04_07730	COG0488	(ABC) transporter
WP8S18E04_07740	COG0516	GMP reductase activity
WP8S18E04_07740	COG0517	IMP dehydrogenase activity
WP8S18E04_07760	COG0835	chemotaxis
WP8S18E04_07760	COG0784	Response regulator, receiver
WP8S18E04_07770	COG2755	lipolytic protein G-D-S-L family
WP8S18E04_07780	COG4181	ATPase activity
WP8S18E04_07790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP8S18E04_07800	COG1090	epimerase
WP8S18E04_07810	COG2200	EAL domain
WP8S18E04_07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E04_07830	COG4935	Belongs to the peptidase S8 family
WP8S18E04_07830	COG2234	aminopeptidase activity
WP8S18E04_07840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP8S18E04_07850	COG3171	Protein conserved in bacteria
WP8S18E04_07860	COG2066	Belongs to the glutaminase family
WP8S18E04_07870	COG2897	thiosulfate sulfurtransferase activity
WP8S18E04_07890	COG1132	(ABC) transporter
WP8S18E04_07930	COG2801	Transposase and inactivated derivatives
WP8S18E04_07960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP8S18E04_07970	COG5001	Diguanylate cyclase
WP8S18E04_07970	COG3300	MHYT domain
WP8S18E04_08010	COG4628	conserved protein (DUF2132)
WP8S18E04_08020	COG0688	phosphatidylethanolamine metabolic process
WP8S18E04_08030	COG1162	GTPase activity
WP8S18E04_08040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP8S18E04_08050	COG1278	Cold shock
WP8S18E04_08070	COG0840	transmembrane signaling receptor activity
WP8S18E04_08080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E04_08130	COG0848	biopolymer transport protein
WP8S18E04_08140	COG0811	peptide transport
WP8S18E04_08150	COG0811	peptide transport
WP8S18E04_08170	COG4206	TonB-dependent receptor
WP8S18E04_08180	COG4174	ABC transporter (Permease)
WP8S18E04_08190	COG4239	(ABC) transporter, permease
WP8S18E04_08210	COG0444	Belongs to the ABC transporter superfamily
WP8S18E04_08220	COG4608	Belongs to the ABC transporter superfamily
WP8S18E04_08240	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S18E04_08260	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP8S18E04_08300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP8S18E04_08350	COG0243	molybdopterin cofactor binding
WP8S18E04_08360	COG1648	precorrin-2 dehydrogenase activity
WP8S18E04_08360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E04_08380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP8S18E04_08380	COG1116	anion transmembrane transporter activity
WP8S18E04_08390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP8S18E04_08400	COG1116	anion transmembrane transporter activity
WP8S18E04_08410	COG2146	nitrite reductase [NAD(P)H] activity
WP8S18E04_08410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E04_08420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E04_08420	COG2146	nitrite reductase [NAD(P)H] activity
WP8S18E04_08430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E04_08440	COG2313	pseudouridylate synthase activity
WP8S18E04_08480	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S18E04_08510	COG2966	Psort location CytoplasmicMembrane, score
WP8S18E04_08520	COG3610	response to peptide
WP8S18E04_08540	COG4175	Glycine betaine
WP8S18E04_08550	COG4176	ABC-type proline glycine betaine transport system permease component
WP8S18E04_08560	COG2113	Glycine betaine
WP8S18E04_08570	COG0175	sulfate reduction
WP8S18E04_08580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E04_08590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP8S18E04_08600	COG0384	phenazine biosynthesis protein PhzF
WP8S18E04_08610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP8S18E04_08620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP8S18E04_08640	COG0786	glutamate:sodium symporter activity
WP8S18E04_08650	COG0252	asparaginase activity
WP8S18E04_08660	COG3139	Protein of unknown function (DUF1315)
WP8S18E04_08700	COG0616	signal peptide processing
WP8S18E04_08710	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E04_08710	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E04_08720	COG0778	Nitroreductase
WP8S18E04_08740	COG0110	maltose O-acetyltransferase activity
WP8S18E04_08750	COG2264	protein methyltransferase activity
WP8S18E04_08760	COG0604	alcohol dehydrogenase
WP8S18E04_08770	COG0583	DNA-binding transcription factor activity
WP8S18E04_08780	COG1263	PTS System
WP8S18E04_08780	COG2190	(PTS) system
WP8S18E04_08780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_08790	COG4145	pantothenate transmembrane transporter activity
WP8S18E04_08800	COG3924	membrane
WP8S18E04_08810	COG0439	Biotin carboxylase
WP8S18E04_08820	COG0511	ligase activity, forming carbon-carbon bonds
WP8S18E04_08830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP8S18E04_08840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S18E04_08870	COG3381	protein complex oligomerization
WP8S18E04_08890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP8S18E04_08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP8S18E04_08920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S18E04_08920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S18E04_08950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP8S18E04_08960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E04_08970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP8S18E04_08980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP8S18E04_08990	COG4172	Belongs to the ABC transporter superfamily
WP8S18E04_09030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP8S18E04_09040	COG0142	geranyltranstransferase activity
WP8S18E04_09050	COG1722	exodeoxyribonuclease VII activity
WP8S18E04_09060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E04_09070	COG1360	Flagellar Motor Protein
WP8S18E04_09100	COG1534	Rna-binding protein
WP8S18E04_09110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP8S18E04_09130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP8S18E04_09140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP8S18E04_09150	COG0149	triose-phosphate isomerase activity
WP8S18E04_09160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP8S18E04_09170	COG0779	Required for maturation of 30S ribosomal subunits
WP8S18E04_09180	COG0195	Participates in both transcription termination and antitermination
WP8S18E04_09190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP8S18E04_09200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP8S18E04_09210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP8S18E04_09220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP8S18E04_09230	COG1185	polyribonucleotide nucleotidyltransferase activity
WP8S18E04_09240	COG2211	Major facilitator Superfamily
WP8S18E04_09250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S18E04_09260	COG1422	Protein of unknown function (DUF1090)
WP8S18E04_09270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E04_09310	COG0312	modulator of DNA gyrase
WP8S18E04_09320	COG0312	modulator of DNA gyrase
WP8S18E04_09340	COG4974	Belongs to the 'phage' integrase family
WP8S18E04_09350	COG1970	mechanosensitive ion channel activity
WP8S18E04_09370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP8S18E04_09380	COG0789	Transcriptional regulator
WP8S18E04_09410	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E04_09430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP8S18E04_09450	COG0321	lipoyl(octanoyl) transferase activity
WP8S18E04_09460	COG2921	Belongs to the UPF0250 family
WP8S18E04_09470	COG1686	Belongs to the peptidase S11 family
WP8S18E04_09480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP8S18E04_09490	COG2951	lytic endotransglycosylase activity
WP8S18E04_09500	COG0772	Belongs to the SEDS family
WP8S18E04_09510	COG0768	penicillin binding
WP8S18E04_09520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP8S18E04_09530	COG0799	negative regulation of ribosome biogenesis
WP8S18E04_09540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP8S18E04_09580	COG0495	leucyl-tRNA aminoacylation
WP8S18E04_09590	COG2888	peptidyl-tyrosine sulfation
WP8S18E04_09600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP8S18E04_09610	COG4535	Mg2 and Co2 transporter CorC
WP8S18E04_09620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP8S18E04_09630	COG1702	phosphate starvation-inducible protein PhoH
WP8S18E04_09640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S18E04_09650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E04_09660	COG1335	isochorismatase
WP8S18E04_09670	COG1278	Cold shock
WP8S18E04_09700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E04_09710	COG2199	diguanylate cyclase activity
WP8S18E04_09730	COG2199	diguanylate cyclase activity
WP8S18E04_09750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S18E04_09780	COG1464	Belongs to the NlpA lipoprotein family
WP8S18E04_09790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP8S18E04_09800	COG2011	ABC-type metal ion transport system permease component
WP8S18E04_09810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP8S18E04_09830	COG0516	GMP reductase activity
WP8S18E04_09840	COG0189	ligase activity
WP8S18E04_09840	COG4067	protein conserved in archaea
WP8S18E04_09880	COG0300	oxidoreductase activity
WP8S18E04_09920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E04_09930	COG3214	Protein conserved in bacteria
WP8S18E04_09960	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S18E04_09970	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S18E04_09980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP8S18E04_09990	COG1053	succinate dehydrogenase
WP8S18E04_10010	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S18E04_10020	COG3264	Mechanosensitive ion channel
WP8S18E04_10020	COG1511	domain protein
WP8S18E04_10040	COG0739	heme binding
WP8S18E04_10070	COG0583	DNA-binding transcription factor activity
WP8S18E04_10100	COG0583	DNA-binding transcription factor activity
WP8S18E04_10110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP8S18E04_10170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP8S18E04_10180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP8S18E04_10200	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP8S18E04_10210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP8S18E04_10220	COG0546	phosphoglycolate phosphatase activity
WP8S18E04_10230	COG0180	Tryptophanyl-tRNA synthetase
WP8S18E04_10260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP8S18E04_10280	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_10310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E04_10360	COG0471	metal ion transport
WP8S18E04_10360	COG0490	domain, Protein
WP8S18E04_10640	COG1196	nuclear chromosome segregation
WP8S18E04_10670	COG0582	viral genome integration into host DNA
WP8S18E04_10680	COG0012	GTP binding
WP8S18E04_10690	COG0193	aminoacyl-tRNA hydrolase activity
WP8S18E04_10700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP8S18E04_10710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP8S18E04_10720	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP8S18E04_10730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP8S18E04_10740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP8S18E04_10750	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S18E04_10770	COG2912	Transglutaminase-like superfamily
WP8S18E04_10780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP8S18E04_10790	COG1301	dicarboxylic acid transport
WP8S18E04_10810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP8S18E04_10840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8S18E04_10850	COG1115	amino acid carrier protein
WP8S18E04_10890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP8S18E04_10910	COG0189	ligase activity
WP8S18E04_10920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP8S18E04_10940	COG3091	SprT-like family
WP8S18E04_10960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP8S18E04_10990	COG2801	Transposase and inactivated derivatives
WP8S18E04_11020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP8S18E04_11030	COG0739	heme binding
WP8S18E04_11040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S18E04_11060	COG1881	PFAM PEBP family protein
WP8S18E04_11080	COG0583	DNA-binding transcription factor activity
WP8S18E04_11100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8S18E04_11120	COG0583	DNA-binding transcription factor activity
WP8S18E04_11130	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_11140	COG0616	signal peptide processing
WP8S18E04_11150	COG3724	N-succinylarginine dihydrolase activity
WP8S18E04_11190	COG0840	transmembrane signaling receptor activity
WP8S18E04_11210	COG2971	BadF BadG BcrA BcrD
WP8S18E04_11230	COG4608	Belongs to the ABC transporter superfamily
WP8S18E04_11240	COG0444	Belongs to the ABC transporter superfamily
WP8S18E04_11250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E04_11280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S18E04_11300	COG0640	Transcriptional regulator
WP8S18E04_11310	COG0798	PFAM Bile acid sodium symporter
WP8S18E04_11320	COG1393	Belongs to the ArsC family
WP8S18E04_11350	COG1677	Flagellar hook-basal body complex protein FliE
WP8S18E04_11370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP8S18E04_11480	COG1684	flagellar biosynthetic protein fliR
WP8S18E04_11500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP8S18E04_11550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP8S18E04_11560	COG2198	Histidine kinase
WP8S18E04_11560	COG0784	Response regulator, receiver
WP8S18E04_11560	COG0643	Histidine kinase
WP8S18E04_11570	COG2201	protein-glutamate methylesterase activity
WP8S18E04_11580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E04_11590	COG1360	Flagellar Motor Protein
WP8S18E04_11600	COG1192	Involved in chromosome partitioning
WP8S18E04_11620	COG0835	chemotaxis
WP8S18E04_11650	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E04_11660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E04_11670	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E04_11680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP8S18E04_11690	COG1138	Cytochrome C-type biogenesis protein
WP8S18E04_11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S18E04_11750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP8S18E04_11760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E04_11760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E04_11790	COG0259	pyridoxamine-phosphate oxidase activity
WP8S18E04_11850	COG3153	acetyltransferase
WP8S18E04_11880	COG0800	Aldolase
WP8S18E04_11890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E04_11910	COG2721	sulfolactate sulfo-lyase activity
WP8S18E04_11920	COG0246	Mannitol dehydrogenase
WP8S18E04_12000	COG2801	Transposase and inactivated derivatives
WP8S18E04_12040	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP8S18E04_12110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP8S18E04_12120	COG2867	negative regulation of translational initiation
WP8S18E04_12140	COG0702	epimerase
WP8S18E04_12150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E04_12160	COG1454	alcohol dehydrogenase
WP8S18E04_12180	COG0564	pseudouridine synthase activity
WP8S18E04_12190	COG1957	nucleoside hydrolase
WP8S18E04_12240	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_12260	COG3263	regulation of cellular component size
WP8S18E04_12280	COG1876	peptidase activity
WP8S18E04_12290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8S18E04_12300	COG1393	Belongs to the ArsC family
WP8S18E04_12320	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E04_12330	COG1473	amidohydrolase
WP8S18E04_12350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S18E04_12360	COG0017	Asparaginyl-tRNA synthetase
WP8S18E04_12390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WP8S18E04_12400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S18E04_12410	COG0156	8-amino-7-oxononanoate synthase activity
WP8S18E04_12420	COG1073	alpha beta
WP8S18E04_12420	COG2226	methyltransferase
WP8S18E04_12430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP8S18E04_12440	COG0501	Belongs to the peptidase M48B family
WP8S18E04_12450	COG0633	Ferredoxin
WP8S18E04_12450	COG3217	Mosc domain protein beta barrel domain protein
WP8S18E04_12450	COG0633	Ferredoxin
WP8S18E04_12450	COG3217	Mosc domain protein beta barrel domain protein
WP8S18E04_12470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP8S18E04_12470	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP8S18E04_12470	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP8S18E04_12470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP8S18E04_12500	COG2841	Protein conserved in bacteria
WP8S18E04_12520	COG0534	Mate efflux family protein
WP8S18E04_12570	COG1454	alcohol dehydrogenase
WP8S18E04_12590	COG1309	transcriptional regulator
WP8S18E04_12620	COG0791	NLP P60 protein
WP8S18E04_12630	COG0583	DNA-binding transcription factor activity
WP8S18E04_12670	COG0500	methyltransferase
WP8S18E04_12680	COG4106	trans-aconitate 2-methyltransferase activity
WP8S18E04_12690	COG1801	Protein of unknown function DUF72
WP8S18E04_12700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP8S18E04_12710	COG0217	transcriptional regulatory protein
WP8S18E04_12720	COG2194	sulfuric ester hydrolase activity
WP8S18E04_12740	COG1846	Transcriptional regulator
WP8S18E04_12740	COG1940	carbohydrate kinase activity
WP8S18E04_12750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S18E04_12760	COG0363	glucosamine-6-phosphate deaminase activity
WP8S18E04_12770	COG1263	PTS System
WP8S18E04_12770	COG2190	(PTS) system
WP8S18E04_12770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_12790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E04_12800	COG0735	belongs to the Fur family
WP8S18E04_12820	COG0716	FMN binding
WP8S18E04_12850	COG0596	Alpha beta hydrolase
WP8S18E04_12860	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP8S18E04_12870	COG0033	Phosphoglucomutase
WP8S18E04_12890	COG1846	Transcriptional regulator
WP8S18E04_12900	COG2951	lytic endotransglycosylase activity
WP8S18E04_12910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP8S18E04_12920	COG4136	ATPase activity
WP8S18E04_12940	COG4134	Bacterial extracellular solute-binding protein
WP8S18E04_12950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S18E04_12960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8S18E04_12980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S18E04_13000	COG0729	surface antigen
WP8S18E04_13010	COG2911	Protein conserved in bacteria
WP8S18E04_13030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP8S18E04_13050	COG0741	lytic transglycosylase activity
WP8S18E04_13080	COG1607	acyl-coa hydrolase
WP8S18E04_13110	COG0741	lytic transglycosylase activity
WP8S18E04_13110	COG1388	LysM domain
WP8S18E04_13120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S18E04_13130	COG2226	methyltransferase
WP8S18E04_13140	COG0328	RNA-DNA hybrid ribonuclease activity
WP8S18E04_13150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S18E04_13170	COG3437	response regulator, receiver
WP8S18E04_13170	COG0784	Response regulator, receiver
WP8S18E04_13180	COG1960	acyl-CoA dehydrogenase activity
WP8S18E04_13190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S18E04_13200	COG0121	glutamine amidotransferase
WP8S18E04_13220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WP8S18E04_13270	COG2197	response regulator
WP8S18E04_13280	COG3850	Histidine kinase
WP8S18E04_13290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP8S18E04_13300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E04_13300	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E04_13320	COG0243	molybdopterin cofactor binding
WP8S18E04_13330	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E04_13340	COG0348	domain, Protein
WP8S18E04_13360	COG3005	denitrification pathway
WP8S18E04_13370	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S18E04_13380	COG0315	cyclic pyranopterin monophosphate synthase activity
WP8S18E04_13390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP8S18E04_13400	COG0314	molybdopterin synthase activity
WP8S18E04_13430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP8S18E04_13440	COG2267	carboxylic ester hydrolase activity
WP8S18E04_13450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S18E04_13470	COG0302	gtp cyclohydrolase
WP8S18E04_13480	COG0840	transmembrane signaling receptor activity
WP8S18E04_13490	COG0840	transmembrane signaling receptor activity
WP8S18E04_13500	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP8S18E04_13520	COG0583	DNA-binding transcription factor activity
WP8S18E04_13550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP8S18E04_13580	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S18E04_13590	COG1166	arginine decarboxylase activity
WP8S18E04_13670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP8S18E04_13680	COG1187	pseudouridine synthase activity
WP8S18E04_13690	COG2807	transmembrane transport
WP8S18E04_13710	COG0583	DNA-binding transcription factor activity
WP8S18E04_13750	COG2979	Protein of unknown function (DUF533)
WP8S18E04_13770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E04_13780	COG1271	oxidase subunit
WP8S18E04_13790	COG1294	oxidase, subunit
WP8S18E04_13810	COG2814	Major facilitator Superfamily
WP8S18E04_13820	COG0656	L-ascorbic acid biosynthetic process
WP8S18E04_13860	COG0583	DNA-binding transcription factor activity
WP8S18E04_13870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP8S18E04_13880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S18E04_13890	COG2271	Major facilitator Superfamily
WP8S18E04_13900	COG1349	DNA-binding transcription factor activity
WP8S18E04_13920	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S18E04_13930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E04_13940	COG0287	Prephenate dehydrogenase
WP8S18E04_13940	COG1605	Chorismate mutase
WP8S18E04_13960	COG3085	chromosome segregation
WP8S18E04_13970	COG4574	serine-type endopeptidase inhibitor activity
WP8S18E04_14010	COG1770	oligopeptidase
WP8S18E04_14020	COG4771	TonB-dependent receptor
WP8S18E04_14030	COG3083	sulfuric ester hydrolase activity
WP8S18E04_14040	COG3082	Protein of unknown function (DUF1414)
WP8S18E04_14050	COG3081	Nucleoid-associated protein
WP8S18E04_14070	COG1175	transmembrane transport
WP8S18E04_14080	COG3833	ABC-type maltose transport systems, permease component
WP8S18E04_14090	COG3842	ATPase activity
WP8S18E04_14110	COG0596	Alpha beta hydrolase
WP8S18E04_14140	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S18E04_14150	COG4783	chaperone-mediated protein folding
WP8S18E04_14170	COG1393	Belongs to the ArsC family
WP8S18E04_14210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_14220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S18E04_14230	COG2431	L-lysine efflux transmembrane transporter activity
WP8S18E04_14250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_14270	COG4160	amino acid transport
WP8S18E04_14290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S18E04_14310	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E04_14320	COG0628	permease
WP8S18E04_14340	COG2373	Large extracellular alpha-helical protein
WP8S18E04_14350	COG4953	penicillin-binding protein 1C
WP8S18E04_14370	COG0301	tRNA thio-modification
WP8S18E04_14370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E04_14400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8S18E04_14410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8S18E04_14420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8S18E04_14450	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_14460	COG1083	cytidylyl-transferase
WP8S18E04_14470	COG0673	inositol 2-dehydrogenase activity
WP8S18E04_14500	COG2089	acid synthase
WP8S18E04_14510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WP8S18E04_14520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP8S18E04_14550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8S18E04_14570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP8S18E04_14620	COG0346	lactoylglutathione lyase activity
WP8S18E04_14630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP8S18E04_14640	COG4660	Part of a membrane complex involved in electron transport
WP8S18E04_14650	COG4659	FMN binding
WP8S18E04_14660	COG4658	electron transport chain
WP8S18E04_14680	COG2878	Part of a membrane complex involved in electron transport
WP8S18E04_14690	COG4657	Part of a membrane complex involved in electron transport
WP8S18E04_14700	COG0697	spore germination
WP8S18E04_14760	COG1288	antiporter activity
WP8S18E04_14770	COG0436	Aminotransferase
WP8S18E04_14790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP8S18E04_14800	COG2027	D-alanyl-D-alanine carboxypeptidase
WP8S18E04_14810	COG1061	Type III restriction enzyme res subunit
WP8S18E04_14820	COG1566	PFAM secretion protein HlyD family protein
WP8S18E04_14840	COG3264	Mechanosensitive ion channel
WP8S18E04_14840	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8S18E04_14850	COG1966	Carbon starvation protein
WP8S18E04_14860	COG3279	Response regulator of the LytR AlgR family
WP8S18E04_14870	COG3275	phosphorelay sensor kinase activity
WP8S18E04_14890	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_14890	COG1454	alcohol dehydrogenase
WP8S18E04_14900	COG2095	MarC family integral membrane protein
WP8S18E04_14920	COG0601	transmembrane transport
WP8S18E04_14930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E04_14960	COG0861	Integral membrane protein TerC family
WP8S18E04_14970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S18E04_14990	COG1301	dicarboxylic acid transport
WP8S18E04_15020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP8S18E04_15050	COG0537	adenosine 5'-monophosphoramidase activity
WP8S18E04_15120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E04_15130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E04_15160	COG2354	Protein conserved in bacteria
WP8S18E04_15170	COG1164	Oligoendopeptidase f
WP8S18E04_15180	COG1164	Oligoendopeptidase f
WP8S18E04_15190	COG3150	esterase
WP8S18E04_15200	COG1252	NADH dehydrogenase
WP8S18E04_15220	COG0393	Putative heavy-metal-binding
WP8S18E04_15230	COG1368	sulfuric ester hydrolase activity
WP8S18E04_15250	COG0527	aspartate kinase activity
WP8S18E04_15260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP8S18E04_15260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S18E04_15270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8S18E04_15320	COG0583	DNA-binding transcription factor activity
WP8S18E04_15330	COG1620	l-lactate permease
WP8S18E04_15340	COG0247	lactate metabolic process
WP8S18E04_15350	COG1139	Iron-sulfur cluster binding protein
WP8S18E04_15390	COG2801	Transposase and inactivated derivatives
WP8S18E04_15430	COG1136	(ABC) transporter
WP8S18E04_15470	COG2814	Major facilitator Superfamily
WP8S18E04_15520	COG0672	)-iron permease
WP8S18E04_15590	COG2308	Evidence 4 Homologs of previously reported genes of
WP8S18E04_15600	COG0300	oxidoreductase activity
WP8S18E04_15620	COG0659	secondary active sulfate transmembrane transporter activity
WP8S18E04_15630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S18E04_15640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP8S18E04_15650	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E04_15660	COG5557	Pfam Polysulphide reductase, NrfD
WP8S18E04_15670	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP8S18E04_15680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP8S18E04_15690	COG1773	rubredoxin
WP8S18E04_15710	COG0601	transmembrane transport
WP8S18E04_15720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E04_15730	COG0444	Belongs to the ABC transporter superfamily
WP8S18E04_15740	COG1124	(ABC) transporter
WP8S18E04_15760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP8S18E04_15780	COG0375	protein maturation
WP8S18E04_15790	COG0309	Hydrogenase expression formation protein (HypE)
WP8S18E04_15810	COG0298	carbon dioxide binding
WP8S18E04_15820	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP8S18E04_15830	COG3158	transport of potassium into the cell
WP8S18E04_15850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP8S18E04_15870	COG0326	Molecular chaperone. Has ATPase activity
WP8S18E04_15880	COG0563	adenylate kinase activity
WP8S18E04_15890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP8S18E04_15900	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP8S18E04_15910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E04_15920	COG0840	transmembrane signaling receptor activity
WP8S18E04_15950	COG3300	MHYT domain
WP8S18E04_15950	COG5001	Diguanylate cyclase
WP8S18E04_16000	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP8S18E04_16010	COG3433	isochorismatase activity
WP8S18E04_16010	COG1535	isochorismatase
WP8S18E04_16020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP8S18E04_16030	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_16050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP8S18E04_16080	COG1120	ATPase activity
WP8S18E04_16090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E04_16100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E04_16110	COG4771	TonB-dependent receptor
WP8S18E04_16190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP8S18E04_16200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP8S18E04_16210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E04_16220	COG0861	Integral membrane protein TerC family
WP8S18E04_16250	COG1022	Amp-dependent synthetase and ligase
WP8S18E04_16270	COG0295	cytidine deaminase activity
WP8S18E04_16280	COG1346	cytolysis
WP8S18E04_16290	COG1380	Effector of murein hydrolase LrgA
WP8S18E04_16300	COG3345	alpha-galactosidase
WP8S18E04_16320	COG2925	Exonuclease
WP8S18E04_16340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP8S18E04_16370	COG3039	Transposase
WP8S18E04_16390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8S18E04_16400	COG1085	galactose-1-phosphate uridylyltransferase
WP8S18E04_16410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E04_16420	COG1609	Transcriptional regulator
WP8S18E04_16430	COG4580	involved in the transport of maltose and maltodextrins
WP8S18E04_16460	COG2801	Transposase and inactivated derivatives
WP8S18E04_16470	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WP8S18E04_16510	COG2182	Extracellular solute-binding protein
WP8S18E04_16520	COG1175	transmembrane transport
WP8S18E04_16530	COG3833	ABC-type maltose transport systems, permease component
WP8S18E04_16540	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WP8S18E04_16550	COG1874	Beta-galactosidase
WP8S18E04_16560	COG1263	PTS System
WP8S18E04_16560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_16580	COG0469	pyruvate kinase activity
WP8S18E04_16600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8S18E04_16610	COG0392	lysyltransferase activity
WP8S18E04_16610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP8S18E04_16640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S18E04_16650	COG0436	Aminotransferase
WP8S18E04_16660	COG0583	DNA-binding transcription factor activity
WP8S18E04_16670	COG2160	L-arabinose isomerase activity
WP8S18E04_16690	COG1069	ribulokinase activity
WP8S18E04_16700	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E04_16710	COG1129	ABC transporter
WP8S18E04_16720	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S18E04_16740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP8S18E04_16750	COG0254	rRNA binding
WP8S18E04_16780	COG1451	nucleotide metabolic process
WP8S18E04_16810	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E04_16830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E04_16830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP8S18E04_16840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8S18E04_16880	COG2009	succinate dehydrogenase
WP8S18E04_16890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP8S18E04_16920	COG0567	Dehydrogenase, E1 component
WP8S18E04_16930	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S18E04_16940	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S18E04_16950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WP8S18E04_16970	COG2983	Belongs to the UPF0260 family
WP8S18E04_16980	COG1882	Formate acetyltransferase
WP8S18E04_16990	COG2116	formate transmembrane transporter activity
WP8S18E04_17000	COG1944	ATP diphosphatase activity
WP8S18E04_17030	COG2076	Multidrug Resistance protein
WP8S18E04_17040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S18E04_17050	COG1278	Cold shock
WP8S18E04_17060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP8S18E04_17070	COG0542	response to heat
WP8S18E04_17080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP8S18E04_17090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP8S18E04_17100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP8S18E04_17110	COG3134	Outer membrane lipoprotein
WP8S18E04_17120	COG3706	GGDEF domain
WP8S18E04_17130	COG0492	ferredoxin-NADP+ reductase activity
WP8S18E04_17140	COG0686	Belongs to the AlaDH PNT family
WP8S18E04_17160	COG0531	amino acid
WP8S18E04_17160	COG1674	ftsk spoiiie
WP8S18E04_17170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP8S18E04_17180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP8S18E04_17190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP8S18E04_17200	COG1286	toxin biosynthetic process
WP8S18E04_17210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP8S18E04_17220	COG2723	6-phospho-beta-galactosidase activity
WP8S18E04_17230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_17230	COG1263	PTS System
WP8S18E04_17240	COG1609	Transcriptional regulator
WP8S18E04_17260	COG4172	Belongs to the ABC transporter superfamily
WP8S18E04_17290	COG4171	peptide transport system, permease
WP8S18E04_17320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP8S18E04_17330	COG1842	Phage shock protein A
WP8S18E04_17360	COG3106	COG3106 Predicted ATPase
WP8S18E04_17370	COG3768	UPF0283 membrane protein
WP8S18E04_17390	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP8S18E04_17440	COG2885	chlorophyll binding
WP8S18E04_17460	COG1570	exodeoxyribonuclease VII activity
WP8S18E04_17480	COG1874	Beta-galactosidase
WP8S18E04_17480	COG0366	Alpha amylase catalytic
WP8S18E04_17500	COG0516	GMP reductase activity
WP8S18E04_17500	COG0517	IMP dehydrogenase activity
WP8S18E04_17510	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S18E04_17510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S18E04_17520	COG0582	viral genome integration into host DNA
WP8S18E04_17920	COG1846	Transcriptional regulator
WP8S18E04_17940	COG0500	methyltransferase
WP8S18E04_17960	COG2062	phosphohistidine phosphatase, SixA
WP8S18E04_17980	COG0697	spore germination
WP8S18E04_18000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP8S18E04_18010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP8S18E04_18030	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S18E04_18040	COG1136	(ABC) transporter
WP8S18E04_18050	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S18E04_18060	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP8S18E04_18080	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP8S18E04_18090	COG0740	serine-type endopeptidase activity
WP8S18E04_18100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP8S18E04_18110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP8S18E04_18120	COG0776	regulation of translation
WP8S18E04_18130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S18E04_18140	COG0488	(ABC) transporter
WP8S18E04_18150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S18E04_18160	COG3162	membrane
WP8S18E04_18190	COG1024	Enoyl-CoA hydratase
WP8S18E04_18200	COG1115	amino acid carrier protein
WP8S18E04_18220	COG3228	Belongs to the MtfA family
WP8S18E04_18230	COG1584	GPR1 FUN34 yaaH family protein
WP8S18E04_18280	COG1024	Enoyl-CoA hydratase
WP8S18E04_18290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP8S18E04_18300	COG1960	acyl-CoA dehydrogenase activity
WP8S18E04_18320	COG1960	acyl-CoA dehydrogenase activity
WP8S18E04_18330	COG1024	Enoyl-CoA hydratase
WP8S18E04_18340	COG1024	Enoyl-CoA hydratase
WP8S18E04_18360	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_18380	COG0730	response to heat
WP8S18E04_18410	COG3267	Type II secretory pathway component ExeA
WP8S18E04_18410	COG3409	Peptidoglycan-binding domain 1 protein
WP8S18E04_18420	COG3039	Transposase
WP8S18E04_18450	COG3621	Patatin-like phospholipase
WP8S18E04_18500	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S18E04_18510	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S18E04_18520	COG1129	ABC transporter
WP8S18E04_18530	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E04_18540	COG0583	DNA-binding transcription factor activity
WP8S18E04_18570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP8S18E04_18580	COG0243	molybdopterin cofactor binding
WP8S18E04_18600	COG0583	DNA-binding transcription factor activity
WP8S18E04_18610	COG2723	6-phospho-beta-galactosidase activity
WP8S18E04_18630	COG0583	DNA-binding transcription factor activity
WP8S18E04_18660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP8S18E04_18670	COG0673	inositol 2-dehydrogenase activity
WP8S18E04_18680	COG0583	DNA-binding transcription factor activity
WP8S18E04_18700	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E04_18710	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E04_18740	COG0417	DNA replication proofreading
WP8S18E04_18750	COG0534	Mate efflux family protein
WP8S18E04_18770	COG0307	riboflavin synthase, alpha
WP8S18E04_18800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E04_18810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP8S18E04_18820	COG0697	spore germination
WP8S18E04_18830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP8S18E04_18880	COG0675	Transposase, IS605 OrfB family
WP8S18E04_18890	COG2996	Protein conserved in bacteria
WP8S18E04_18920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S18E04_18930	COG3099	Belongs to the UPF0263 family
WP8S18E04_18940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP8S18E04_18950	COG2894	cell division
WP8S18E04_18960	COG0850	regulation of cytokinetic process
WP8S18E04_18970	COG3100	YcgL domain-containing protein
WP8S18E04_18980	COG2951	lytic endotransglycosylase activity
WP8S18E04_18990	COG1760	l-serine dehydratase
WP8S18E04_19000	COG1760	l-serine dehydratase
WP8S18E04_19010	COG3123	guanosine phosphorylase activity
WP8S18E04_19020	COG1301	dicarboxylic acid transport
WP8S18E04_19050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP8S18E04_19060	COG2067	long-chain fatty acid transport protein
WP8S18E04_19070	COG2067	long-chain fatty acid transport protein
WP8S18E04_19090	COG1595	DNA-templated transcription, initiation
WP8S18E04_19150	COG0714	Associated with various cellular activities
WP8S18E04_19160	COG0183	Belongs to the thiolase family
WP8S18E04_19170	COG1024	Enoyl-CoA hydratase
WP8S18E04_19170	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S18E04_19190	COG4681	YaeQ
WP8S18E04_19230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E04_19260	COG3134	Outer membrane lipoprotein
WP8S18E04_19270	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E04_19290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP8S18E04_19290	COG0140	phosphoribosyl-ATP diphosphatase activity
WP8S18E04_19300	COG0107	imidazoleglycerol-phosphate synthase activity
WP8S18E04_19310	COG0784	Response regulator, receiver
WP8S18E04_19310	COG2205	protein histidine kinase activity
WP8S18E04_19310	COG2198	Histidine kinase
WP8S18E04_19330	COG3437	response regulator, receiver
WP8S18E04_19340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP8S18E04_19350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP8S18E04_19360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S18E04_19360	COG0131	Imidazoleglycerol-phosphate dehydratase
WP8S18E04_19370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP8S18E04_19380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP8S18E04_19390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP8S18E04_19410	COG1199	ATP-dependent helicase activity
WP8S18E04_19420	COG1214	PFAM Peptidase M22, glycoprotease
WP8S18E04_19440	COG0596	Alpha beta hydrolase
WP8S18E04_19450	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E04_19460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WP8S18E04_19480	COG0697	spore germination
WP8S18E04_19500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E04_19510	COG2832	Protein of unknown function (DUF454)
WP8S18E04_19520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP8S18E04_19540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP8S18E04_19550	COG0583	DNA-binding transcription factor activity
WP8S18E04_19580	COG2197	response regulator
WP8S18E04_19590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8S18E04_19590	COG0517	IMP dehydrogenase activity
WP8S18E04_19590	COG0617	tRNA 3'-terminal CCA addition
WP8S18E04_19600	COG1643	Atp-dependent helicase
WP8S18E04_19620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP8S18E04_19630	COG3437	response regulator, receiver
WP8S18E04_19630	COG4999	Histidine kinase
WP8S18E04_19630	COG3850	Histidine kinase
WP8S18E04_19630	COG2205	protein histidine kinase activity
WP8S18E04_19670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S18E04_19680	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP8S18E04_19690	COG0709	Synthesizes selenophosphate from selenide and ATP
WP8S18E04_19720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S18E04_19730	COG0840	transmembrane signaling receptor activity
WP8S18E04_19740	COG1254	Belongs to the acylphosphatase family
WP8S18E04_19760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E04_19760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E04_19770	COG0489	protein tyrosine kinase activity
WP8S18E04_19780	COG0572	uridine kinase
WP8S18E04_19790	COG0717	Belongs to the dCTP deaminase family
WP8S18E04_19800	COG0306	phosphate transporter
WP8S18E04_19810	COG1530	ribonuclease E activity
WP8S18E04_19820	COG0564	pseudouridine synthase activity
WP8S18E04_19860	COG1399	metal-binding, possibly nucleic acid-binding protein
WP8S18E04_19870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP8S18E04_19880	COG0416	fatty acid biosynthetic process
WP8S18E04_19890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP8S18E04_19910	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E04_19920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP8S18E04_19930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8S18E04_19940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP8S18E04_19950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP8S18E04_19960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP8S18E04_19970	COG0470	DNA polymerase III
WP8S18E04_19980	COG0084	hydrolase, TatD family'
WP8S18E04_20010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP8S18E04_20010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E04_20020	COG3008	intermembrane lipid transfer
WP8S18E04_20030	COG2995	paraquat-inducible protein a
WP8S18E04_20050	COG3141	response to X-ray
WP8S18E04_20150	COG4128	Pfam Zonular occludens toxin
WP8S18E04_20160	COG1067	ATP-dependent peptidase activity
WP8S18E04_20170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S18E04_20210	COG0116	Belongs to the methyltransferase superfamily
WP8S18E04_20210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S18E04_20230	COG0167	dihydroorotate dehydrogenase activity
WP8S18E04_20240	COG2902	Dehydrogenase
WP8S18E04_20260	COG0308	aminopeptidase N
WP8S18E04_20280	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP8S18E04_20290	COG1956	GAF domain-containing protein
WP8S18E04_20310	COG3278	Belongs to the heme-copper respiratory oxidase family
WP8S18E04_20340	COG2010	Cytochrome c
WP8S18E04_20360	COG2217	Heavy metal translocating P-type atpase
WP8S18E04_20390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S18E04_20400	COG0589	response to stress
WP8S18E04_20410	COG0037	tRNA processing
WP8S18E04_20440	COG0625	glutathione transferase activity
WP8S18E04_20450	COG1869	D-ribose catabolic process
WP8S18E04_20460	COG1129	ABC transporter
WP8S18E04_20470	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S18E04_20480	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E04_20490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E04_20500	COG1609	Transcriptional regulator
WP8S18E04_20570	COG0776	regulation of translation
WP8S18E04_20580	COG0072	phenylalanine-tRNA ligase activity
WP8S18E04_20580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E04_20590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP8S18E04_20600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP8S18E04_20610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP8S18E04_20620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP8S18E04_20630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP8S18E04_20680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E04_20700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S18E04_20710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S18E04_20720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E04_20730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP8S18E04_20740	COG3313	Fe-S protein
WP8S18E04_20750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E04_20750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E04_20750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP8S18E04_20760	COG1105	Belongs to the carbohydrate kinase PfkB family
WP8S18E04_20770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_20770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_20780	COG1609	Transcriptional regulator
WP8S18E04_20790	COG0814	amino acid
WP8S18E04_20810	COG5654	RES domain protein
WP8S18E04_20820	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_20840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP8S18E04_20850	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S18E04_20860	COG2840	Smr protein MutS2
WP8S18E04_20930	COG2824	Alkylphosphonate utilization operon protein PhnA
WP8S18E04_20950	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_20980	COG0588	phosphoglycerate mutase activity
WP8S18E04_21050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8S18E04_21060	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP8S18E04_21080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E04_21090	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP8S18E04_21110	COG0205	6-phosphofructokinase activity
WP8S18E04_21120	COG1473	amidohydrolase
WP8S18E04_21130	COG1011	Hydrolase
WP8S18E04_21140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S18E04_21160	COG3593	DNA synthesis involved in DNA repair
WP8S18E04_21190	COG0583	DNA-binding transcription factor activity
WP8S18E04_21200	COG0730	response to heat
WP8S18E04_21220	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP8S18E04_21240	COG0386	Belongs to the glutathione peroxidase family
WP8S18E04_21250	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_21320	COG2329	Antibiotic biosynthesis monooxygenase
WP8S18E04_21330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8S18E04_21370	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP8S18E04_21390	COG2501	S4 domain
WP8S18E04_21420	COG1132	(ABC) transporter
WP8S18E04_21430	COG1132	(ABC) transporter
WP8S18E04_21450	COG3118	belongs to the thioredoxin family
WP8S18E04_21460	COG0471	metal ion transport
WP8S18E04_21480	COG0058	SHG alpha-glucan phosphorylase activity
WP8S18E04_21550	COG0814	amino acid
WP8S18E04_21560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP8S18E04_21570	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E04_21580	COG2766	serine protein kinase
WP8S18E04_21590	COG2718	Belongs to the UPF0229 family
WP8S18E04_21600	COG2719	SpoVR family
WP8S18E04_21610	COG2186	Transcriptional regulator
WP8S18E04_21620	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S18E04_21630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP8S18E04_21640	COG0586	Pfam SNARE associated Golgi protein
WP8S18E04_21660	COG0556	nucleotide-excision repair
WP8S18E04_21680	COG0569	domain protein
WP8S18E04_21680	COG2985	domain, Protein
WP8S18E04_21690	COG0739	heme binding
WP8S18E04_21690	COG0741	lytic transglycosylase activity
WP8S18E04_21690	COG1196	nuclear chromosome segregation
WP8S18E04_21700	COG3181	Tripartite tricarboxylate transporter family receptor
WP8S18E04_21730	COG4565	transcriptional regulatory protein
WP8S18E04_21740	COG3290	protein histidine kinase activity
WP8S18E04_21750	COG1846	Transcriptional regulator
WP8S18E04_21750	COG1940	carbohydrate kinase activity
WP8S18E04_21760	COG0840	transmembrane signaling receptor activity
WP8S18E04_21770	COG3012	SEC-C Motif Domain Protein
WP8S18E04_21780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP8S18E04_21790	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP8S18E04_21810	COG0247	lactate metabolic process
WP8S18E04_21860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP8S18E04_21870	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E04_21880	COG3301	Polysulphide reductase, NrfD
WP8S18E04_21890	COG1138	Cytochrome C-type biogenesis protein
WP8S18E04_21910	COG3088	subunit of a heme lyase
WP8S18E04_21910	COG4235	cytochrome complex assembly
WP8S18E04_21930	COG3046	protein related to deoxyribodipyrimidine photolyase
WP8S18E04_21940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E04_21950	COG0517	IMP dehydrogenase activity
WP8S18E04_21950	COG0617	tRNA 3'-terminal CCA addition
WP8S18E04_21950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8S18E04_21970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP8S18E04_21980	COG0583	DNA-binding transcription factor activity
WP8S18E04_22000	COG4774	siderophore transport
WP8S18E04_22010	COG2200	EAL domain
WP8S18E04_22010	COG2771	luxR family
WP8S18E04_22020	COG1917	Cupin 2, conserved barrel domain protein
WP8S18E04_22020	COG4977	sequence-specific DNA binding
WP8S18E04_22030	COG0583	DNA-binding transcription factor activity
WP8S18E04_22040	COG2910	NAD(P)H-binding
WP8S18E04_22060	COG0626	cystathionine gamma-synthase activity
WP8S18E04_22070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP8S18E04_22100	COG2226	methyltransferase
WP8S18E04_22200	COG3039	Transposase
WP8S18E04_22370	COG3550	peptidyl-serine autophosphorylation
WP8S18E04_22380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP8S18E04_22390	COG1349	DNA-binding transcription factor activity
WP8S18E04_22450	COG1435	thymidine kinase activity
WP8S18E04_22460	COG1757	Na H antiporter
WP8S18E04_22470	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8S18E04_22480	COG2096	Adenosyltransferase
WP8S18E04_22490	COG3530	Putative quorum-sensing-regulated virulence factor
WP8S18E04_22500	COG0602	queuosine metabolic process
WP8S18E04_22510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP8S18E04_22550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP8S18E04_22570	COG0776	regulation of translation
WP8S18E04_22580	COG0539	negative regulation of cytoplasmic translation
WP8S18E04_22590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP8S18E04_22600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S18E04_22660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP8S18E04_22670	COG3300	MHYT domain
WP8S18E04_22670	COG5001	Diguanylate cyclase
WP8S18E04_22690	COG0583	DNA-binding transcription factor activity
WP8S18E04_22700	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_22750	COG4989	oxidoreductase activity
WP8S18E04_22760	COG0724	RNA recognition motif
WP8S18E04_22800	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP8S18E04_22850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8S18E04_22860	COG1192	Involved in chromosome partitioning
WP8S18E04_22870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E04_22880	COG1360	Flagellar Motor Protein
WP8S18E04_22890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E04_22900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E04_22910	COG0649	NAD binding
WP8S18E04_22910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E04_22940	COG1034	ATP synthesis coupled electron transport
WP8S18E04_22950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP8S18E04_22960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E04_22970	COG0839	Belongs to the complex I subunit 6 family
WP8S18E04_22980	COG0713	ATP synthesis coupled electron transport
WP8S18E04_23000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E04_23010	COG1007	ATP synthesis coupled electron transport
WP8S18E04_23020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP8S18E04_23020	COG0047	phosphoribosylformylglycinamidine synthase activity
WP8S18E04_23030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S18E04_23050	COG1645	bacterial-type flagellum-dependent swarming motility
WP8S18E04_23060	COG1160	GTP binding
WP8S18E04_23070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E04_23080	COG2976	Protein conserved in bacteria
WP8S18E04_23090	COG0124	histidyl-tRNA synthetase
WP8S18E04_23110	COG1426	Protein conserved in bacteria
WP8S18E04_23130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP8S18E04_23140	COG0105	UTP biosynthetic process
WP8S18E04_23150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S18E04_23170	COG0633	Ferredoxin
WP8S18E04_23180	COG0443	Heat shock 70 kDa protein
WP8S18E04_23190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S18E04_23200	COG0316	Belongs to the HesB IscA family
WP8S18E04_23210	COG0822	iron-sulfur transferase activity
WP8S18E04_23220	COG1104	cysteine desulfurase activity
WP8S18E04_23250	COG3154	lipid carrier protein
WP8S18E04_23260	COG0826	peptidase U32
WP8S18E04_23270	COG0826	peptidase U32
WP8S18E04_23290	COG2897	thiosulfate sulfurtransferase activity
WP8S18E04_23300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E04_23310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E04_23320	COG1862	Preprotein translocase
WP8S18E04_23330	COG0343	queuine tRNA-ribosyltransferase activity
WP8S18E04_23340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP8S18E04_23350	COG0517	IMP dehydrogenase activity
WP8S18E04_23360	COG0450	alkyl hydroperoxide reductase
WP8S18E04_23370	COG3634	alkyl hydroperoxide reductase activity
WP8S18E04_23380	COG0477	Major facilitator Superfamily
WP8S18E04_23420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S18E04_23420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S18E04_23430	COG0509	glycine decarboxylation via glycine cleavage system
WP8S18E04_23440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP8S18E04_23450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E04_23460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E04_23490	COG2814	Major facilitator Superfamily
WP8S18E04_23500	COG0444	Belongs to the ABC transporter superfamily
WP8S18E04_23510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E04_23520	COG0601	transmembrane transport
WP8S18E04_23540	COG0625	glutathione transferase activity
WP8S18E04_23550	COG0625	glutathione transferase activity
WP8S18E04_23570	COG0483	inositol monophosphate 1-phosphatase activity
WP8S18E04_23600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S18E04_23610	COG2056	Na+-H+ antiporter family
WP8S18E04_23620	COG2814	Major facilitator Superfamily
WP8S18E04_23630	COG0583	DNA-binding transcription factor activity
WP8S18E04_23640	COG5001	Diguanylate cyclase
WP8S18E04_23670	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S18E04_23690	COG0247	lactate metabolic process
WP8S18E04_23690	COG0277	FAD linked oxidase domain protein
WP8S18E04_23720	COG1253	flavin adenine dinucleotide binding
WP8S18E04_23730	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E04_23750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8S18E04_23760	COG0647	UMP catabolic process
WP8S18E04_23780	COG0367	asparagine synthase
WP8S18E04_23810	COG0625	glutathione transferase activity
WP8S18E04_23830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP8S18E04_23860	COG0564	pseudouridine synthase activity
WP8S18E04_23870	COG5001	Diguanylate cyclase
WP8S18E04_23880	COG0840	transmembrane signaling receptor activity
WP8S18E04_23890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP8S18E04_23970	COG0670	Belongs to the BI1 family
WP8S18E04_23980	COG1289	transmembrane transporter activity
WP8S18E04_23990	COG2920	part of a sulfur-relay system
WP8S18E04_24000	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP8S18E04_24010	COG0285	dihydrofolate synthase activity
WP8S18E04_24020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP8S18E04_24030	COG0101	tRNA pseudouridine synthase activity
WP8S18E04_24050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S18E04_24060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S18E04_24080	COG1464	Belongs to the NlpA lipoprotein family
WP8S18E04_24120	COG1119	ATPase activity
WP8S18E04_24130	COG0574	Belongs to the PEP-utilizing enzyme family
WP8S18E04_24130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP8S18E04_24140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP8S18E04_24160	COG1113	amino acid transport
WP8S18E04_24340	COG1242	4 iron, 4 sulfur cluster binding
WP8S18E04_24350	COG0069	glutamate synthase activity
WP8S18E04_24350	COG0070	glutamate synthase
WP8S18E04_24350	COG0067	glutamate synthase
WP8S18E04_24360	COG0493	'glutamate synthase
WP8S18E04_24380	COG0765	amino acid transport
WP8S18E04_24390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_24430	COG4104	PAAR repeat-containing protein
WP8S18E04_24450	COG2948	multi-organism process
WP8S18E04_24480	COG3846	protein secretion by the type IV secretion system
WP8S18E04_24510	COG3451	type IV secretory pathway VirB4
WP8S18E04_24530	COG3838	Conjugal transfer protein Trbc
WP8S18E04_24540	COG4962	Type ii secretion system protein e
WP8S18E04_24580	COG0583	DNA-binding transcription factor activity
WP8S18E04_24640	COG2076	Multidrug Resistance protein
WP8S18E04_24680	COG4959	Type IV secretory pathway protease TraF
WP8S18E04_24710	COG1192	Involved in chromosome partitioning
WP8S18E04_24770	COG5489	Protein of unknown function (DUF736)
WP8S18E04_24820	COG2003	Belongs to the UPF0758 family
WP8S18E04_24960	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_25020	COG3706	GGDEF domain
WP8S18E04_25030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8S18E04_25040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP8S18E04_25050	COG0505	Belongs to the CarA family
WP8S18E04_25060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP8S18E04_25080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP8S18E04_25090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP8S18E04_25100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S18E04_25110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8S18E04_25120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E04_25130	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP8S18E04_25140	COG4139	cobalamin transport
WP8S18E04_25190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP8S18E04_25210	COG0023	Translation Initiation Factor
WP8S18E04_25220	COG2119	membrane
WP8S18E04_25290	COG2203	Gaf domain
WP8S18E04_25290	COG2199	diguanylate cyclase activity
WP8S18E04_25320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S18E04_25340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E04_25350	COG2261	transglycosylase associated protein
WP8S18E04_25360	COG1309	transcriptional regulator
WP8S18E04_25370	COG0604	alcohol dehydrogenase
WP8S18E04_25390	COG2801	Transposase and inactivated derivatives
WP8S18E04_25420	COG0322	excinuclease ABC activity
WP8S18E04_25430	COG2197	response regulator
WP8S18E04_25440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP8S18E04_25450	COG2835	tetraacyldisaccharide 4'-kinase activity
WP8S18E04_25460	COG1663	tetraacyldisaccharide 4'-kinase activity
WP8S18E04_25470	COG1132	(ABC) transporter
WP8S18E04_25480	COG0658	competence protein
WP8S18E04_25480	COG2333	competence protein COMEC
WP8S18E04_25510	COG0433	COG0433 Predicted ATPase
WP8S18E04_25520	COG1448	Aminotransferase
WP8S18E04_25550	COG1199	ATP-dependent helicase activity
WP8S18E04_25570	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP8S18E04_25580	COG0477	Major facilitator Superfamily
WP8S18E04_25600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP8S18E04_25610	COG1785	Belongs to the alkaline phosphatase family
WP8S18E04_25650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S18E04_25660	COG3706	GGDEF domain
WP8S18E04_25670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_25680	COG0765	amino acid transport
WP8S18E04_25700	COG1126	abc transporter atp-binding protein
WP8S18E04_25730	COG0531	amino acid
WP8S18E04_25760	COG1253	flavin adenine dinucleotide binding
WP8S18E04_25770	COG0704	Plays a role in the regulation of phosphate uptake
WP8S18E04_25790	COG0581	inorganic phosphate transmembrane transporter activity
WP8S18E04_25800	COG0573	inorganic phosphate transmembrane transporter activity
WP8S18E04_25810	COG0590	tRNA wobble adenosine to inosine editing
WP8S18E04_25830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP8S18E04_25870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP8S18E04_25880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP8S18E04_25890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP8S18E04_25900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP8S18E04_25920	COG3852	Histidine kinase
WP8S18E04_25950	COG2716	regulation of RNA biosynthetic process
WP8S18E04_25960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP8S18E04_25980	COG2239	Acts as a magnesium transporter
WP8S18E04_26010	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP8S18E04_26010	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP8S18E04_26020	COG1706	bacterial-type flagellum-dependent cell motility
WP8S18E04_26030	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP8S18E04_26060	COG1749	Flagellar hook protein flgE
WP8S18E04_26090	COG1815	bacterial-type flagellum-dependent cell motility
WP8S18E04_26100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP8S18E04_26110	COG0784	Response regulator, receiver
WP8S18E04_26110	COG0835	chemotaxis
WP8S18E04_26120	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP8S18E04_26150	COG0622	Phosphoesterase
WP8S18E04_26160	COG0675	Transposase, IS605 OrfB family
WP8S18E04_26170	COG4166	transmembrane transport
WP8S18E04_26200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E04_26220	COG0697	spore germination
WP8S18E04_26230	COG4166	transmembrane transport
WP8S18E04_26280	COG1278	Cold shock
WP8S18E04_26360	COG3132	Protein of unknown function, DUF480
WP8S18E04_26380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E04_26410	COG3206	protein involved in exopolysaccharide biosynthesis
WP8S18E04_26410	COG0489	protein tyrosine kinase activity
WP8S18E04_26420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WP8S18E04_26440	COG1216	Glycosyl transferase, family 2
WP8S18E04_26480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WP8S18E04_26480	COG0463	Glycosyl transferase, family 2
WP8S18E04_26510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP8S18E04_26530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S18E04_26620	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP8S18E04_26650	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_26730	COG1737	Transcriptional regulator
WP8S18E04_26740	COG0469	pyruvate kinase activity
WP8S18E04_26760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_26770	COG1960	acyl-CoA dehydrogenase activity
WP8S18E04_26790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP8S18E04_26820	COG0583	DNA-binding transcription factor activity
WP8S18E04_26850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP8S18E04_26870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_26880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_26890	COG1309	transcriptional regulator
WP8S18E04_26920	COG1946	Acyl-CoA thioesterase
WP8S18E04_26950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP8S18E04_26970	COG0009	L-threonylcarbamoyladenylate synthase
WP8S18E04_26980	COG0613	PHP domain protein
WP8S18E04_26990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP8S18E04_27010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S18E04_27010	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8S18E04_27020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S18E04_27030	COG0134	indole-3-glycerol-phosphate synthase activity
WP8S18E04_27030	COG0135	phosphoribosylanthranilate isomerase activity
WP8S18E04_27040	COG0133	tryptophan synthase activity
WP8S18E04_27050	COG0159	tryptophan synthase activity
WP8S18E04_27070	COG1396	sequence-specific DNA binding
WP8S18E04_27080	COG3550	peptidyl-serine autophosphorylation
WP8S18E04_27140	COG5507	3-demethylubiquinone-9 3-methyltransferase
WP8S18E04_27150	COG2814	Major facilitator Superfamily
WP8S18E04_27160	COG0109	protoheme IX farnesyltransferase activity
WP8S18E04_27170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP8S18E04_27180	COG1845	cytochrome c oxidase, subunit III
WP8S18E04_27190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP8S18E04_27200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP8S18E04_27210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8S18E04_27220	COG0583	DNA-binding transcription factor activity
WP8S18E04_27260	COG1846	Transcriptional regulator
WP8S18E04_27290	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WP8S18E04_27320	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_27340	COG0708	Exodeoxyribonuclease III
WP8S18E04_27360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_27380	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_27410	COG0095	Lipoate-protein ligase
WP8S18E04_27470	COG0640	Transcriptional regulator
WP8S18E04_27490	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E04_27510	COG1285	pathogenesis
WP8S18E04_27570	COG0484	heat shock protein binding
WP8S18E04_27580	COG0443	Heat shock 70 kDa protein
WP8S18E04_27590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP8S18E04_27600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP8S18E04_27610	COG3706	GGDEF domain
WP8S18E04_27620	COG0497	DNA recombination
WP8S18E04_27650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_27660	COG0577	efflux transmembrane transporter activity
WP8S18E04_27660	COG1136	(ABC) transporter
WP8S18E04_27670	COG1538	Outer membrane efflux protein
WP8S18E04_27680	COG2375	cellular response to nickel ion
WP8S18E04_27690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E04_27700	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8S18E04_27710	COG0583	DNA-binding transcription factor activity
WP8S18E04_27720	COG3048	D-serine ammonia-lyase activity
WP8S18E04_27740	COG0538	isocitrate dehydrogenase activity
WP8S18E04_27810	COG0456	acetyltransferase
WP8S18E04_27820	COG1187	pseudouridine synthase activity
WP8S18E04_27840	COG0482	sulfurtransferase activity
WP8S18E04_27850	COG2915	High frequency lysogenization protein hflD homolog
WP8S18E04_27860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP8S18E04_27870	COG2850	peptidyl-arginine hydroxylation
WP8S18E04_27890	COG3264	Mechanosensitive ion channel
WP8S18E04_27890	COG1196	nuclear chromosome segregation
WP8S18E04_27940	COG2233	PERMEase
WP8S18E04_27960	COG0281	malic enzyme
WP8S18E04_27970	COG0746	molybdenum cofactor guanylyltransferase activity
WP8S18E04_27980	COG1763	Mo-molybdopterin cofactor biosynthetic process
WP8S18E04_27990	COG1289	transmembrane transporter activity
WP8S18E04_28000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E04_28060	COG3220	belongs to the UPF0276 family
WP8S18E04_28090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP8S18E04_28130	COG0454	-acetyltransferase
WP8S18E04_28140	COG1396	sequence-specific DNA binding
WP8S18E04_28170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S18E04_28180	COG0083	homoserine kinase activity
WP8S18E04_28200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP8S18E04_28210	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP8S18E04_28240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S18E04_28270	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_28280	COG4988	ABC transporter
WP8S18E04_28290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP8S18E04_28330	COG1720	tRNA m6t6A37 methyltransferase activity
WP8S18E04_28360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP8S18E04_28370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP8S18E04_28380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_28400	COG2190	(PTS) system
WP8S18E04_28410	COG3038	cytochrome b561
WP8S18E04_28430	COG0420	3'-5' exonuclease activity
WP8S18E04_28440	COG1247	-acetyltransferase
WP8S18E04_28450	COG2974	May be involved in recombination
WP8S18E04_28480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP8S18E04_28480	COG4651	solute:proton antiporter activity
WP8S18E04_28550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E04_28560	COG1917	Cupin 2, conserved barrel domain protein
WP8S18E04_28560	COG1396	sequence-specific DNA binding
WP8S18E04_28570	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_28600	COG0531	amino acid
WP8S18E04_28620	COG0531	amino acid
WP8S18E04_28640	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP8S18E04_28660	COG3384	dioxygenase
WP8S18E04_28670	COG2205	protein histidine kinase activity
WP8S18E04_28670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_28680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_28680	COG2198	Histidine kinase
WP8S18E04_28680	COG2205	protein histidine kinase activity
WP8S18E04_28680	COG0784	Response regulator, receiver
WP8S18E04_28710	COG2205	protein histidine kinase activity
WP8S18E04_28710	COG0784	Response regulator, receiver
WP8S18E04_28720	COG1376	ErfK ybiS ycfS ynhG family protein
WP8S18E04_28720	COG1388	LysM domain
WP8S18E04_28750	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP8S18E04_28760	COG0791	NLP P60 protein
WP8S18E04_28800	COG3118	belongs to the thioredoxin family
WP8S18E04_28820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S18E04_28830	COG0788	formyltetrahydrofolate deformylase activity
WP8S18E04_28880	COG1196	nuclear chromosome segregation
WP8S18E04_28880	COG0741	lytic transglycosylase activity
WP8S18E04_28880	COG0739	heme binding
WP8S18E04_28890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S18E04_28900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP8S18E04_28910	COG0673	inositol 2-dehydrogenase activity
WP8S18E04_28990	COG1032	radical SAM domain protein
WP8S18E04_29000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_29020	COG3706	GGDEF domain
WP8S18E04_29030	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S18E04_29050	COG0733	neurotransmitter:sodium symporter activity
WP8S18E04_29110	COG0281	malic enzyme
WP8S18E04_29120	COG2207	Transcriptional regulator
WP8S18E04_29130	COG0534	Mate efflux family protein
WP8S18E04_29160	COG2233	PERMEase
WP8S18E04_29170	COG0095	Lipoate-protein ligase
WP8S18E04_29180	COG1115	amino acid carrier protein
WP8S18E04_29190	COG0019	diaminopimelate decarboxylase activity
WP8S18E04_29210	COG0678	peroxiredoxin activity
WP8S18E04_29220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP8S18E04_29240	COG1126	abc transporter atp-binding protein
WP8S18E04_29250	COG0765	amino acid transport
WP8S18E04_29260	COG4597	amino acid ABC transporter
WP8S18E04_29270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_29300	COG1131	(ABC) transporter
WP8S18E04_29310	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S18E04_29340	COG1940	carbohydrate kinase activity
WP8S18E04_29360	COG4783	chaperone-mediated protein folding
WP8S18E04_29380	COG5002	protein histidine kinase activity
WP8S18E04_29390	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_29400	COG0346	lactoylglutathione lyase activity
WP8S18E04_29410	COG3706	GGDEF domain
WP8S18E04_29420	COG3284	Transcriptional regulator
WP8S18E04_29430	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_29450	COG0697	spore germination
WP8S18E04_29460	COG0667	Aldo Keto reductase
WP8S18E04_29490	COG3290	protein histidine kinase activity
WP8S18E04_29510	COG1566	PFAM secretion protein HlyD family protein
WP8S18E04_29560	COG0602	queuosine metabolic process
WP8S18E04_29570	COG1328	CTP reductase activity
WP8S18E04_29590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP8S18E04_29600	COG3115	cell septum assembly
WP8S18E04_29610	COG1196	nuclear chromosome segregation
WP8S18E04_29630	COG2860	membrane
WP8S18E04_29650	COG3108	Peptidase M15
WP8S18E04_29660	COG2989	Protein conserved in bacteria
WP8S18E04_29690	COG0463	Glycosyl transferase, family 2
WP8S18E04_29720	COG0366	Alpha amylase catalytic
WP8S18E04_29790	COG2199	diguanylate cyclase activity
WP8S18E04_29790	COG2203	Gaf domain
WP8S18E04_29800	COG0037	tRNA processing
WP8S18E04_29830	COG0488	(ABC) transporter
WP8S18E04_29850	COG0531	amino acid
WP8S18E04_29860	COG0814	amino acid
WP8S18E04_29890	COG0825	malonyl-CoA metabolic process
WP8S18E04_29910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP8S18E04_29920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E04_29930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E04_29940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S18E04_29950	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E04_29980	COG0750	zinc metalloprotease
WP8S18E04_29990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP8S18E04_30000	COG0575	Belongs to the CDS family
WP8S18E04_30010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP8S18E04_30020	COG0233	cytoplasmic translational termination
WP8S18E04_30030	COG0528	UMP kinase activity
WP8S18E04_30040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP8S18E04_30050	COG0052	Belongs to the universal ribosomal protein uS2 family
WP8S18E04_30060	COG0024	Methionine aminopeptidase
WP8S18E04_30070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP8S18E04_30080	COG2171	N-acyltransferase activity
WP8S18E04_30100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E04_30100	COG1263	PTS System
WP8S18E04_30120	COG4580	involved in the transport of maltose and maltodextrins
WP8S18E04_30140	COG0564	pseudouridine synthase activity
WP8S18E04_30150	COG3098	single-species biofilm formation
WP8S18E04_30200	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP8S18E04_30220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S18E04_30220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S18E04_30240	COG3706	GGDEF domain
WP8S18E04_30250	COG1611	Belongs to the LOG family
WP8S18E04_30260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E04_30270	COG0473	3-isopropylmalate dehydrogenase activity
WP8S18E04_30290	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP8S18E04_30320	COG0583	DNA-binding transcription factor activity
WP8S18E04_30330	COG0840	transmembrane signaling receptor activity
WP8S18E04_30340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8S18E04_30370	COG1477	protein flavinylation
WP8S18E04_30380	COG2871	sodium ion transport
WP8S18E04_30390	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E04_30400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E04_30410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E04_30420	COG1805	sodium ion transport
WP8S18E04_30430	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E04_30440	COG0271	Belongs to the BolA IbaG family
WP8S18E04_30450	COG2813	Specifically methylates the guanine in position
WP8S18E04_30470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S18E04_30490	COG2211	Major facilitator Superfamily
WP8S18E04_30510	COG1666	GTP binding
WP8S18E04_30530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP8S18E04_30550	COG0659	secondary active sulfate transmembrane transporter activity
WP8S18E04_30560	COG5000	phosphorelay sensor kinase activity
WP8S18E04_30560	COG5002	protein histidine kinase activity
WP8S18E04_30580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_30590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E04_30640	COG1609	Transcriptional regulator
WP8S18E04_30650	COG2182	Extracellular solute-binding protein
WP8S18E04_30660	COG0840	transmembrane signaling receptor activity
WP8S18E04_30670	COG1472	Belongs to the glycosyl hydrolase 3 family
WP8S18E04_30680	COG5297	Belongs to the glycosyl hydrolase family 6
WP8S18E04_30680	COG2273	Hydrolase Family 16
WP8S18E04_30690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E04_30710	COG2723	6-phospho-beta-galactosidase activity
WP8S18E04_30720	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP8S18E04_30750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E04_30770	COG1151	hydroxylamine reductase activity
WP8S18E04_30780	COG0783	Belongs to the Dps family
WP8S18E04_30830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP8S18E04_30860	COG0300	oxidoreductase activity
WP8S18E04_30880	COG0415	Belongs to the DNA photolyase family
WP8S18E04_30890	COG0789	Transcriptional regulator
WP8S18E04_30900	COG3272	Protein of unknown function (DUF1722)
WP8S18E04_30950	COG1605	Chorismate mutase
WP8S18E04_30950	COG0077	Prephenate dehydratase
WP8S18E04_31000	COG2133	pyrroloquinoline quinone binding
WP8S18E04_31020	COG1349	DNA-binding transcription factor activity
WP8S18E04_31030	COG2084	Dehydrogenase
WP8S18E04_31040	COG3395	kinase activity
WP8S18E04_31050	COG0235	Class ii aldolase
WP8S18E04_31060	COG3622	Belongs to the hyi family
WP8S18E04_31070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S18E04_31080	COG2610	gluconate transmembrane transporter activity
WP8S18E04_31100	COG0840	transmembrane signaling receptor activity
WP8S18E04_31120	COG0300	oxidoreductase activity
WP8S18E04_31170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP8S18E04_31210	COG3813	Protein conserved in bacteria
WP8S18E04_31230	COG0826	peptidase U32
WP8S18E04_31240	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_31370	COG1566	PFAM secretion protein HlyD family protein
WP8S18E04_31390	COG0114	fumarate hydratase activity
WP8S18E04_31410	COG0506	proline dehydrogenase activity
WP8S18E04_31410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP8S18E04_31410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP8S18E04_31420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S18E04_31450	COG0737	Belongs to the 5'-nucleotidase family
WP8S18E04_31490	COG2204	response regulator
WP8S18E04_31500	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S18E04_31520	COG2900	Belongs to the SlyX family
WP8S18E04_31530	COG1047	Peptidyl-prolyl cis-trans
WP8S18E04_31540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP8S18E04_31560	COG0784	Response regulator, receiver
WP8S18E04_31560	COG0835	chemotaxis
WP8S18E04_31570	COG0429	hydrolase of the alpha beta-hydrolase fold
WP8S18E04_31580	COG5001	Diguanylate cyclase
WP8S18E04_31580	COG4251	negative regulation of phosphorylation
WP8S18E04_31580	COG3706	GGDEF domain
WP8S18E04_31580	COG2203	Gaf domain
WP8S18E04_31590	COG3089	Belongs to the UPF0270 family
WP8S18E04_31600	COG3954	Phosphoribulokinase
WP8S18E04_31630	COG1765	OsmC-like protein
WP8S18E04_31650	COG2226	methyltransferase
WP8S18E04_31670	COG2205	protein histidine kinase activity
WP8S18E04_31670	COG2202	Pas domain
WP8S18E04_31680	COG2814	Major facilitator Superfamily
WP8S18E04_31730	COG0748	coenzyme F420 binding
WP8S18E04_31740	COG3721	Heme iron utilization protein
WP8S18E04_31760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E04_31810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WP8S18E04_31830	COG0463	Glycosyl transferase, family 2
WP8S18E04_31840	COG0741	lytic transglycosylase activity
WP8S18E04_31850	COG0488	(ABC) transporter
WP8S18E04_31870	COG2252	PERMEase
WP8S18E04_31880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S18E04_31890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP8S18E04_31900	COG3178	'Phosphotransferase
WP8S18E04_31910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP8S18E04_31930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP8S18E04_31940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP8S18E04_31950	COG2967	ApaG domain
WP8S18E04_31960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8S18E04_31980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP8S18E04_31990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E04_32000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E04_32020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP8S18E04_32030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP8S18E04_32040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP8S18E04_32050	COG0142	geranyltranstransferase activity
WP8S18E04_32060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP8S18E04_32070	COG0330	HflC and HflK could
WP8S18E04_32080	COG0330	HflC and HflK could
WP8S18E04_32090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP8S18E04_32100	COG1923	regulation of RNA biosynthetic process
WP8S18E04_32110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP8S18E04_32120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP8S18E04_32140	COG0802	atpase or kinase
WP8S18E04_32150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP8S18E04_32150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP8S18E04_32190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP8S18E04_32200	COG2011	ABC-type metal ion transport system permease component
WP8S18E04_32210	COG1464	Belongs to the NlpA lipoprotein family
WP8S18E04_32250	COG0784	Response regulator, receiver
WP8S18E04_32250	COG2205	protein histidine kinase activity
WP8S18E04_32280	COG2198	Histidine kinase
WP8S18E04_32280	COG5002	protein histidine kinase activity
WP8S18E04_32280	COG0784	Response regulator, receiver
WP8S18E04_32320	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP8S18E04_32350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP8S18E04_32360	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP8S18E04_32370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S18E04_32380	COG2716	regulation of RNA biosynthetic process
WP8S18E04_32390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP8S18E04_32400	COG3013	Belongs to the UPF0304 family
WP8S18E04_32420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8S18E04_32430	COG0857	belongs to the CobB CobQ family
WP8S18E04_32430	COG0280	phosphate acetyltransferase
WP8S18E04_32440	COG0440	acetolactate synthase activity
WP8S18E04_32450	COG0028	Belongs to the TPP enzyme family
WP8S18E04_32480	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E04_32500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8S18E04_32510	COG0473	3-isopropylmalate dehydrogenase activity
WP8S18E04_32520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP8S18E04_32530	COG0066	3-isopropylmalate dehydratase activity
WP8S18E04_32560	COG4143	(ABC) transporter
WP8S18E04_32570	COG1178	ABC-type Fe3 transport system permease component
WP8S18E04_32580	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP8S18E04_32600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP8S18E04_32620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S18E04_32690	COG2205	protein histidine kinase activity
WP8S18E04_32700	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_32710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E04_32720	COG0577	efflux transmembrane transporter activity
WP8S18E04_32720	COG1136	(ABC) transporter
WP8S18E04_32740	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP8S18E04_32820	COG2199	diguanylate cyclase activity
WP8S18E04_32820	COG2203	Gaf domain
WP8S18E04_32830	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_32850	COG1917	Cupin 2, conserved barrel domain protein
WP8S18E04_32850	COG2207	Transcriptional regulator
WP8S18E04_32890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WP8S18E04_32900	COG2801	Transposase and inactivated derivatives
WP8S18E04_32900	COG3415	Transposase
WP8S18E04_32910	COG2801	Transposase and inactivated derivatives
WP8S18E04_32930	COG2801	Transposase and inactivated derivatives
WP8S18E04_32940	COG0154	amidase activity
WP8S18E04_32950	COG2957	Belongs to the agmatine deiminase family
WP8S18E04_32980	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E04_32990	COG0456	acetyltransferase
WP8S18E04_33010	COG0456	acetyltransferase
WP8S18E04_33050	COG5001	Diguanylate cyclase
WP8S18E04_33050	COG5002	protein histidine kinase activity
WP8S18E04_33060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP8S18E04_33090	COG0456	acetyltransferase
WP8S18E04_33110	COG1022	Amp-dependent synthetase and ligase
WP8S18E04_33130	COG1794	racemase activity, acting on amino acids and derivatives
WP8S18E04_33160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E04_33190	COG0733	neurotransmitter:sodium symporter activity
WP8S18E04_33200	COG0733	neurotransmitter:sodium symporter activity
WP8S18E04_33230	COG0561	phosphatase activity
WP8S18E04_33290	COG1846	Transcriptional regulator
WP8S18E04_33300	COG2130	NADP-dependent
WP8S18E04_33310	COG1051	belongs to the nudix hydrolase family
WP8S18E04_33360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP8S18E04_33370	COG1640	4-alpha-glucanotransferase
WP8S18E04_33380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S18E04_33390	COG0676	glucose-6-phosphate 1-epimerase activity
WP8S18E04_33400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP8S18E04_33410	COG0840	transmembrane signaling receptor activity
WP8S18E04_33420	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP8S18E04_33430	COG2885	chlorophyll binding
WP8S18E04_33440	COG0823	Involved in the tonB-independent uptake of proteins
WP8S18E04_33470	COG0811	peptide transport
WP8S18E04_33480	COG0824	Thioesterase
WP8S18E04_33490	COG3790	cyd operon protein YbgE
WP8S18E04_33500	COG4890	Cyd operon protein YbgT
WP8S18E04_33510	COG1294	oxidase, subunit
WP8S18E04_33520	COG1271	oxidase subunit
WP8S18E04_33530	COG2255	four-way junction helicase activity
WP8S18E04_33540	COG0632	four-way junction helicase activity
WP8S18E04_33570	COG0442	prolyl-tRNA aminoacylation
WP8S18E04_33580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S18E04_33590	COG4221	oxidoreductase activity
WP8S18E04_33620	COG1024	Enoyl-CoA hydratase
WP8S18E04_33650	COG4166	transmembrane transport
WP8S18E04_33670	COG0840	transmembrane signaling receptor activity
WP8S18E04_33680	COG0840	transmembrane signaling receptor activity
WP8S18E04_33690	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_33740	COG1230	cation diffusion facilitator family transporter
WP8S18E04_33760	COG0457	Tetratricopeptide repeat
WP8S18E04_33760	COG3118	belongs to the thioredoxin family
WP8S18E04_33780	COG1215	transferase activity, transferring glycosyl groups
WP8S18E04_33790	COG1215	transferase activity, transferring glycosyl groups
WP8S18E04_33830	COG2194	sulfuric ester hydrolase activity
WP8S18E04_33840	COG1448	Aminotransferase
WP8S18E04_33870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S18E04_33880	COG1328	CTP reductase activity
WP8S18E04_33940	COG3397	chitin binding
WP8S18E04_33950	COG0583	DNA-binding transcription factor activity
WP8S18E04_33960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP8S18E04_33970	COG4208	sulfate ABC transporter
WP8S18E04_33980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP8S18E04_34000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP8S18E04_34010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8S18E04_34020	COG0564	pseudouridine synthase activity
WP8S18E04_34060	COG0459	protein refolding
WP8S18E04_34070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP8S18E04_34080	COG0534	Mate efflux family protein
WP8S18E04_34090	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP8S18E04_34100	COG1027	Aspartate ammonia-lyase
WP8S18E04_34110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S18E04_34120	COG2918	glutathione biosynthetic process
WP8S18E04_34130	COG0612	Peptidase, M16
WP8S18E04_34140	COG1238	metal cluster binding
WP8S18E04_34220	COG0359	binds to the 23S rRNA
WP8S18E04_34230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP8S18E04_34240	COG0360	Binds together with S18 to 16S ribosomal RNA
WP8S18E04_34250	COG1914	H( )-stimulated, divalent metal cation uptake system
WP8S18E04_34270	COG2153	protein acetylation
WP8S18E04_34290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S18E04_34300	COG0557	exoribonuclease II activity
WP8S18E04_34310	COG3706	GGDEF domain
WP8S18E04_34320	COG1854	S-ribosylhomocysteine lyase activity
WP8S18E04_34350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP8S18E04_34350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S18E04_34420	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8S18E04_34430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP8S18E04_34440	COG1047	Peptidyl-prolyl cis-trans
WP8S18E04_34450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP8S18E04_34460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP8S18E04_34470	COG0196	riboflavin kinase activity
WP8S18E04_34480	COG0728	peptidoglycan biosynthetic process
WP8S18E04_34490	COG0268	Binds directly to 16S ribosomal RNA
WP8S18E04_34500	COG0640	Transcriptional regulator
WP8S18E04_34510	COG0583	DNA-binding transcription factor activity
WP8S18E04_34530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S18E04_34540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP8S18E04_34550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP8S18E04_34570	COG1051	belongs to the nudix hydrolase family
WP8S18E04_34610	COG0335	large ribosomal subunit rRNA binding
WP8S18E04_34620	COG0336	Belongs to the RNA methyltransferase TrmD family
WP8S18E04_34630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP8S18E04_34640	COG0228	four-way junction DNA binding
WP8S18E04_34650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP8S18E04_34660	COG4137	Cytochrome C assembly protein
WP8S18E04_34670	COG4536	flavin adenine dinucleotide binding
WP8S18E04_34690	COG1017	nitric oxide dioxygenase activity
WP8S18E04_34690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E04_34700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP8S18E04_34710	COG0039	L-malate dehydrogenase activity
WP8S18E04_34720	COG4160	amino acid transport
WP8S18E04_34730	COG4215	(ABC) transporter
WP8S18E04_34740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E04_34750	COG1126	abc transporter atp-binding protein
WP8S18E04_34760	COG1438	arginine binding
WP8S18E04_34770	COG2837	iron assimilation
WP8S18E04_34780	COG3842	ATPase activity
WP8S18E04_34810	COG0347	Belongs to the P(II) protein family
WP8S18E04_34840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E04_34850	COG0583	DNA-binding transcription factor activity
WP8S18E04_34880	COG1929	Belongs to the glycerate kinase type-1 family
WP8S18E04_34890	COG2610	gluconate transmembrane transporter activity
WP8S18E04_34900	COG3835	regulator
WP8S18E04_34910	COG3112	Uncharacterised protein family (UPF0231)
WP8S18E04_34950	COG1872	DUF167
WP8S18E04_34960	COG0762	integral membrane protein
WP8S18E04_34970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP8S18E04_34980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP8S18E04_35000	COG2805	Type II/IV secretion system protein
WP8S18E04_35010	COG3022	response to hydroperoxide
WP8S18E04_35020	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_35030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP8S18E04_35070	COG0735	belongs to the Fur family
WP8S18E04_35080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E04_35110	COG0776	regulation of translation
WP8S18E04_35120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP8S18E04_35140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP8S18E04_35170	COG0560	Phosphoserine phosphatase
WP8S18E04_35190	COG3447	MASE1 domain protein
WP8S18E04_35190	COG5001	Diguanylate cyclase
WP8S18E04_35190	COG5002	protein histidine kinase activity
WP8S18E04_35200	COG4520	surface antigen
WP8S18E04_35220	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP8S18E04_35230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP8S18E04_35240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP8S18E04_35260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E04_35270	COG0084	hydrolase, TatD family'
WP8S18E04_35280	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8S18E04_35310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E04_35320	COG0004	ammonium transporteR
WP8S18E04_35350	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S18E04_35360	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S18E04_35370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S18E04_35380	COG2927	DNA polymerase III (CHI subunit)
WP8S18E04_35390	COG0525	valine-tRNA ligase activity
WP8S18E04_35400	COG1253	flavin adenine dinucleotide binding
WP8S18E04_35410	COG0586	Pfam SNARE associated Golgi protein
WP8S18E04_35420	COG1686	Belongs to the peptidase S11 family
WP8S18E04_35430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP8S18E04_35440	COG0527	aspartate kinase activity
WP8S18E04_35450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8S18E04_35460	COG2137	regulation of response to DNA damage stimulus
WP8S18E04_35470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP8S18E04_35480	COG1546	Belongs to the CinA family
WP8S18E04_35510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP8S18E04_35560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP8S18E04_35570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP8S18E04_35600	COG0477	Major facilitator Superfamily
WP8S18E04_35610	COG0523	cobalamin synthesis protein
WP8S18E04_35630	COG1280	lysine exporter protein (LysE YggA)
WP8S18E04_35650	COG2200	EAL domain
WP8S18E04_35660	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP8S18E04_35670	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S18E04_35680	COG0840	transmembrane signaling receptor activity
WP8S18E04_35690	COG0840	transmembrane signaling receptor activity
WP8S18E04_35710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S18E04_35720	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S18E04_35730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP8S18E04_35740	COG2186	Transcriptional regulator
WP8S18E04_35780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S18E04_35790	COG1459	type II secretion system
WP8S18E04_35800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WP8S18E04_35820	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP8S18E04_35830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP8S18E04_35840	COG0494	nUDIX hydrolase
WP8S18E04_35860	COG0653	protein targeting
WP8S18E04_35880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP8S18E04_35890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP8S18E04_35900	COG0849	cell division
WP8S18E04_35910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP8S18E04_35920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S18E04_35930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP8S18E04_35940	COG0772	Belongs to the SEDS family
WP8S18E04_35950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP8S18E04_35960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S18E04_35970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP8S18E04_35980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP8S18E04_35990	COG0768	penicillin binding
WP8S18E04_36000	COG3116	cell division
WP8S18E04_36010	COG0275	rRNA processing
WP8S18E04_36020	COG2001	Belongs to the MraZ family
WP8S18E04_36030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP8S18E04_36040	COG3107	peptidoglycan biosynthetic process
WP8S18E04_36050	COG0792	nuclease activity
WP8S18E04_36060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S18E04_36070	COG2823	Periplasmic or secreted lipoprotein
WP8S18E04_36080	COG2969	positive regulation of protein catabolic process
WP8S18E04_36090	COG0625	glutathione transferase activity
WP8S18E04_36100	COG2857	Cytochrome c1
WP8S18E04_36110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP8S18E04_36120	COG0723	plastoquinol--plastocyanin reductase activity
WP8S18E04_36130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP8S18E04_36140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP8S18E04_36150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP8S18E04_36170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S18E04_36180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S18E04_36240	COG3964	amidohydrolase
WP8S18E04_36280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_36290	COG1660	Displays ATPase and GTPase activities
WP8S18E04_36300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E04_36320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP8S18E04_36330	COG1137	ATPase activity
WP8S18E04_36340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP8S18E04_36360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP8S18E04_36370	COG0517	IMP dehydrogenase activity
WP8S18E04_36370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP8S18E04_36380	COG1127	ABC transporter
WP8S18E04_36390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP8S18E04_36400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S18E04_36410	COG2854	intermembrane phospholipid transfer
WP8S18E04_36430	COG5007	Belongs to the BolA IbaG family
WP8S18E04_36440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP8S18E04_36460	COG1494	fructose-1,6-bisphosphatase
WP8S18E04_36520	COG1733	regulation of RNA biosynthetic process
WP8S18E04_36550	COG3932	Exopolysaccharide synthesis, ExoD
WP8S18E04_36560	COG2199	diguanylate cyclase activity
WP8S18E04_36560	COG2203	Gaf domain
WP8S18E04_36650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S18E04_36660	COG2022	thiamine diphosphate biosynthetic process
WP8S18E04_36680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S18E04_36690	COG0352	thiamine-phosphate diphosphorylase activity
WP8S18E04_36700	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP8S18E04_36730	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_36740	COG0642	Histidine kinase
WP8S18E04_36750	COG0189	ligase activity
WP8S18E04_36820	COG2321	neutral zinc metallopeptidase
WP8S18E04_36840	COG0477	Major facilitator Superfamily
WP8S18E04_36870	COG0312	modulator of DNA gyrase
WP8S18E04_36880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S18E04_36890	COG3164	Protein of unknown function
WP8S18E04_36900	COG1530	ribonuclease E activity
WP8S18E04_36910	COG0424	maF-like protein
WP8S18E04_36920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP8S18E04_36930	COG1792	Involved in formation and maintenance of cell shape
WP8S18E04_36940	COG1077	Cell shape determining protein MreB Mrl
WP8S18E04_37150	COG2801	Transposase and inactivated derivatives
WP8S18E04_37160	COG2200	EAL domain
WP8S18E04_37170	COG0387	Pfam Sodium calcium exchanger
WP8S18E04_37180	COG2986	histidine ammonia-lyase
WP8S18E04_37190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP8S18E04_37200	COG0010	Belongs to the arginase family
WP8S18E04_37210	COG1228	amidohydrolase
WP8S18E04_37220	COG2188	Transcriptional regulator
WP8S18E04_37230	COG0288	reversible hydration of carbon dioxide
WP8S18E04_37250	COG2177	Part of the ABC transporter FtsEX involved in
WP8S18E04_37260	COG2884	Cell division ATP-binding protein ftsE
WP8S18E04_37270	COG0552	protein localization to endoplasmic reticulum
WP8S18E04_37280	COG0742	ribosomal rna small subunit methyltransferase
WP8S18E04_37330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S18E04_37350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S18E04_37370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S18E04_37390	COG2095	MarC family integral membrane protein
WP8S18E04_37410	COG1301	dicarboxylic acid transport
WP8S18E04_37430	COG0583	DNA-binding transcription factor activity
WP8S18E04_37460	COG3714	YhhN family
WP8S18E04_37490	COG2358	TRAP transporter, solute receptor (TAXI family
WP8S18E04_37500	COG1770	oligopeptidase
WP8S18E04_37530	COG4221	oxidoreductase activity
WP8S18E04_37540	COG0583	DNA-binding transcription factor activity
WP8S18E04_37550	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8S18E04_37590	COG0203	ribosomal protein L17
WP8S18E04_37600	COG0202	RNA polymerase activity
WP8S18E04_37610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP8S18E04_37620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP8S18E04_37630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP8S18E04_37640	COG0201	protein transport
WP8S18E04_37650	COG0200	Binds to the 23S rRNA
WP8S18E04_37660	COG1841	ribosomal large subunit assembly
WP8S18E04_37670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP8S18E04_37680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP8S18E04_37690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP8S18E04_37700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP8S18E04_37710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP8S18E04_37720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP8S18E04_37730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP8S18E04_37740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP8S18E04_37750	COG0255	Belongs to the universal ribosomal protein uL29 family
WP8S18E04_37760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP8S18E04_37770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP8S18E04_37780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP8S18E04_37790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP8S18E04_37800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP8S18E04_37810	COG0089	rRNA binding
WP8S18E04_37820	COG0088	Forms part of the polypeptide exit tunnel
WP8S18E04_37830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP8S18E04_37840	COG0051	transcription antitermination factor activity, RNA binding
WP8S18E04_37860	COG2205	protein histidine kinase activity
WP8S18E04_37870	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_37880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S18E04_37890	COG2183	response to ionizing radiation
WP8S18E04_37920	COG0596	Alpha beta hydrolase
WP8S18E04_37930	COG1040	competence protein
WP8S18E04_37940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP8S18E04_37940	COG0316	Belongs to the HesB IscA family
WP8S18E04_37950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP8S18E04_37960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP8S18E04_37970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E04_37980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP8S18E04_37990	COG4942	peptidase
WP8S18E04_38010	COG1609	Transcriptional regulator
WP8S18E04_38030	COG0800	Aldolase
WP8S18E04_38040	COG0129	dihydroxy-acid dehydratase activity
WP8S18E04_38050	COG3265	gluconokinase activity
WP8S18E04_38060	COG2610	gluconate transmembrane transporter activity
WP8S18E04_38070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S18E04_38080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP8S18E04_38100	COG0456	acetyltransferase
WP8S18E04_38130	COG1490	D-aminoacyl-tRNA deacylase activity
WP8S18E04_38140	COG1295	ribonuclease BN
WP8S18E04_38160	COG0174	glutamine synthetase
WP8S18E04_38180	COG3852	Histidine kinase
WP8S18E04_38200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8S18E04_38210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8S18E04_38230	COG3078	GTPase activator activity
WP8S18E04_38250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP8S18E04_38260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP8S18E04_38270	COG0408	coproporphyrinogen oxidase activity
WP8S18E04_38280	COG0009	L-threonylcarbamoyladenylate synthase
WP8S18E04_38290	COG0551	DNA topoisomerase type I activity
WP8S18E04_38300	COG2922	Belongs to the Smg family
WP8S18E04_38310	COG0758	DNA mediated transformation
WP8S18E04_38330	COG0242	peptide deformylase activity
WP8S18E04_38340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP8S18E04_38350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E04_38350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E04_38360	COG0569	domain protein
WP8S18E04_38370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E04_38380	COG1322	Protein conserved in bacteria
WP8S18E04_38420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E04_38440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S18E04_38440	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S18E04_38470	COG1396	sequence-specific DNA binding
WP8S18E04_38480	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E04_38500	COG2962	Rard protein
WP8S18E04_38610	COG0583	DNA-binding transcription factor activity
WP8S18E04_38650	COG2801	Transposase and inactivated derivatives
WP8S18E04_38660	COG0210	DNA helicase
WP8S18E04_38730	COG0583	DNA-binding transcription factor activity
WP8S18E04_38780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E04_38790	COG0385	Bile acid
WP8S18E04_38800	COG0531	amino acid
WP8S18E04_38810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E04_38820	COG0531	amino acid
WP8S18E04_38830	COG2731	YhcH YjgK YiaL family protein
WP8S18E04_38840	COG3250	beta-galactosidase activity
WP8S18E04_38850	COG1609	Transcriptional regulator
WP8S18E04_38860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP8S18E04_38870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E04_38870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E04_38880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP8S18E04_38890	COG3074	FtsZ-dependent cytokinesis
WP8S18E04_38910	COG1045	serine acetyltransferase
WP8S18E04_38930	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_38940	COG2205	protein histidine kinase activity
WP8S18E04_38950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP8S18E04_38960	COG0534	Mate efflux family protein
WP8S18E04_38990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S18E04_39000	COG2937	Belongs to the GPAT DAPAT family
WP8S18E04_39010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP8S18E04_39020	COG3161	chorismate lyase activity
WP8S18E04_39030	COG1580	Controls the rotational direction of flagella during chemotaxis
WP8S18E04_39070	COG1609	Transcriptional regulator
WP8S18E04_39170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S18E04_39190	COG0156	8-amino-7-oxononanoate synthase activity
WP8S18E04_39200	COG1063	alcohol dehydrogenase
WP8S18E04_39240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP8S18E04_39250	COG2166	iron-sulfur cluster assembly
WP8S18E04_39260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP8S18E04_39280	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP8S18E04_39290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E04_39300	COG1739	Uncharacterized protein family UPF0029
WP8S18E04_39310	COG0006	proline dipeptidase activity
WP8S18E04_39320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S18E04_39330	COG1024	Enoyl-CoA hydratase
WP8S18E04_39330	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S18E04_39340	COG0183	Belongs to the thiolase family
WP8S18E04_39350	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_39390	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S18E04_39400	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S18E04_39410	COG0251	oxidation-reduction process
WP8S18E04_39420	COG2885	chlorophyll binding
WP8S18E04_39440	COG1335	isochorismatase
WP8S18E04_39450	COG2818	Glycosylase
WP8S18E04_39460	COG0752	glycyl-tRNA synthetase alpha subunit
WP8S18E04_39470	COG0751	glycine-tRNA ligase activity
WP8S18E04_39500	COG3706	GGDEF domain
WP8S18E04_39500	COG2203	Gaf domain
WP8S18E04_39500	COG4251	negative regulation of phosphorylation
WP8S18E04_39500	COG5001	Diguanylate cyclase
WP8S18E04_39530	COG0814	amino acid
WP8S18E04_39540	COG0814	amino acid
WP8S18E04_39550	COG3033	Beta-eliminating lyase
WP8S18E04_39560	COG0348	domain, Protein
WP8S18E04_39580	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E04_39590	COG1773	rubredoxin
WP8S18E04_39590	COG0426	domain, Protein
WP8S18E04_39600	COG3604	Transcriptional regulator
WP8S18E04_39610	COG1609	Transcriptional regulator
WP8S18E04_39690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E04_39720	COG2960	long-chain fatty acid transporting porin activity
WP8S18E04_39740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP8S18E04_39770	COG3118	belongs to the thioredoxin family
WP8S18E04_39780	COG0513	Belongs to the DEAD box helicase family
WP8S18E04_39790	COG0248	Ppx GppA phosphatase
WP8S18E04_39810	COG0742	ribosomal rna small subunit methyltransferase
WP8S18E04_39830	COG0339	signal peptide processing
WP8S18E04_39850	COG0084	hydrolase, TatD family'
WP8S18E04_39860	COG0805	protein transport
WP8S18E04_39870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S18E04_39880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S18E04_39890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP8S18E04_39900	COG3165	ubiquinone biosynthetic process from chorismate
WP8S18E04_39920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP8S18E04_39930	COG0402	S-adenosylhomocysteine deaminase activity
WP8S18E04_39960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP8S18E04_39970	COG0848	biopolymer transport protein
WP8S18E04_39980	COG0811	peptide transport
WP8S18E04_39990	COG0811	peptide transport
WP8S18E04_40010	COG2771	luxR family
WP8S18E04_40020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP8S18E04_40030	COG1349	DNA-binding transcription factor activity
WP8S18E04_40040	COG0745	RESPONSE REGULATOR receiver
WP8S18E04_40050	COG2205	protein histidine kinase activity
WP8S18E04_40070	COG4452	Inner membrane protein CreD
WP8S18E04_40080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP8S18E04_40090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP8S18E04_40100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP8S18E04_40110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP8S18E04_40120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP8S18E04_40130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP8S18E04_40140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP8S18E04_40160	COG0356	it plays a direct role in the translocation of protons across the membrane
WP8S18E04_40180	COG1475	DNA binding
WP8S18E04_40190	COG1192	Involved in chromosome partitioning
WP8S18E04_40200	COG0357	Ribosomal RNA small subunit methyltransferase G
WP8S18E04_40210	COG0445	tRNA wobble uridine modification
WP8S18E04_40220	COG0716	FMN binding
WP8S18E04_40230	COG4774	siderophore transport
WP8S18E04_40240	COG4615	Cyclic peptide transporter
WP8S18E04_40250	COG1120	ATPase activity
WP8S18E04_40260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8S18E04_40280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP8S18E04_40290	COG0706	membrane insertase activity
WP8S18E04_40300	COG0594	ribonuclease P activity
WP8S18E04_40310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP8S18E04_P10080	COG2003	Belongs to the UPF0758 family
WP8S18E04_P10100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S18E04_P10110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8S18E04_P10120	COG3093	addiction module antidote protein HigA
WP8S18E04_P10170	COG0675	Transposase, IS605 OrfB family