locus-tag	class	description
HUI95_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUI95_00010	COG0592	DNA-directed DNA polymerase activity
HUI95_00030	COG2378	regulation of single-species biofilm formation
HUI95_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
HUI95_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
HUI95_00045	COG3977	Valine--pyruvate aminotransferase
HUI95_00060	COG2814	Major facilitator Superfamily
HUI95_00065	COG0745	RESPONSE REGULATOR receiver
HUI95_00070	COG2205	protein histidine kinase activity
HUI95_00105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUI95_00110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_00110	COG4191	Histidine kinase
HUI95_00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUI95_00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_00125	COG1309	transcriptional regulator
HUI95_00160	COG2271	Major facilitator Superfamily
HUI95_00180	COG0561	phosphatase activity
HUI95_00185	COG2267	carboxylic ester hydrolase activity
HUI95_00195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUI95_00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUI95_00205	COG1758	RNA polymerase activity
HUI95_00215	COG0859	PFAM glycosyl transferase family 9
HUI95_00220	COG3642	lipopolysaccharide core region biosynthetic process
HUI95_00260	COG0589	response to stress
HUI95_00265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUI95_00275	COG1528	Iron-storage protein
HUI95_00280	COG2081	HI0933 family
HUI95_00285	COG2223	nitrite transmembrane transporter activity
HUI95_00305	COG3188	usher protein
HUI95_00325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_00325	COG2205	protein histidine kinase activity
HUI95_00335	COG3275	phosphorelay sensor kinase activity
HUI95_00340	COG3279	Response regulator of the LytR AlgR family
HUI95_00345	COG2223	nitrite transmembrane transporter activity
HUI95_00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUI95_00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUI95_00370	COG0583	DNA-binding transcription factor activity
HUI95_00380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUI95_00420	COG1609	Transcriptional regulator
HUI95_00425	COG3250	beta-galactosidase activity
HUI95_00430	COG2731	YhcH YjgK YiaL family protein
HUI95_00435	COG0531	amino acid
HUI95_00440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUI95_00445	COG0531	amino acid
HUI95_00450	COG0385	Bile acid
HUI95_00455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUI95_00475	COG0583	DNA-binding transcription factor activity
HUI95_00480	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUI95_00485	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUI95_00490	COG3845	ABC transporter
HUI95_00495	COG1744	ABC transporter substrate-binding protein PnrA-like
HUI95_00500	COG0210	DNA helicase
HUI95_00505	COG2801	Transposase and inactivated derivatives
HUI95_00515	COG1192	Involved in chromosome partitioning
HUI95_00535	COG0583	DNA-binding transcription factor activity
HUI95_00555	COG3161	chorismate lyase activity
HUI95_00590	COG1280	lysine exporter protein (LysE YggA)
HUI95_00600	COG2391	methyltransferase activity
HUI95_00610	COG1280	lysine exporter protein (LysE YggA)
HUI95_00620	COG2962	Rard protein
HUI95_00630	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_00635	COG1396	sequence-specific DNA binding
HUI95_00640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUI95_00650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUI95_00650	COG0519	Catalyzes the synthesis of GMP from XMP
HUI95_00655	COG0686	Belongs to the AlaDH PNT family
HUI95_00660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUI95_00680	COG1322	Protein conserved in bacteria
HUI95_00685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUI95_00690	COG0569	domain protein
HUI95_00695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUI95_00695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUI95_00700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUI95_00705	COG0242	peptide deformylase activity
HUI95_00715	COG0758	DNA mediated transformation
HUI95_00720	COG2922	Belongs to the Smg family
HUI95_00725	COG0551	DNA topoisomerase type I activity
HUI95_00735	COG0009	L-threonylcarbamoyladenylate synthase
HUI95_00740	COG0408	coproporphyrinogen oxidase activity
HUI95_00745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUI95_00755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUI95_00765	COG3078	GTPase activator activity
HUI95_00780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUI95_00785	COG2204	response regulator
HUI95_00790	COG3852	Histidine kinase
HUI95_00800	COG0174	glutamine synthetase
HUI95_00805	COG1217	gtp-binding protein TYPA
HUI95_00810	COG1295	ribonuclease BN
HUI95_00815	COG1490	D-aminoacyl-tRNA deacylase activity
HUI95_00825	COG0456	acetyltransferase
HUI95_00835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUI95_00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUI95_00845	COG2610	gluconate transmembrane transporter activity
HUI95_00850	COG3265	gluconokinase activity
HUI95_00855	COG0129	dihydroxy-acid dehydratase activity
HUI95_00860	COG0800	Aldolase
HUI95_00865	COG1609	Transcriptional regulator
HUI95_00875	COG4942	peptidase
HUI95_00880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUI95_00885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUI95_00890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HUI95_00895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUI95_00900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUI95_00900	COG0316	Belongs to the HesB IscA family
HUI95_00905	COG1040	competence protein
HUI95_00910	COG0596	Alpha beta hydrolase
HUI95_00930	COG2183	response to ionizing radiation
HUI95_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUI95_00955	COG0051	transcription antitermination factor activity, RNA binding
HUI95_00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUI95_00965	COG0088	Forms part of the polypeptide exit tunnel
HUI95_00970	COG0089	rRNA binding
HUI95_00975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUI95_00980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUI95_00985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUI95_00990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUI95_00995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUI95_01000	COG0255	Belongs to the universal ribosomal protein uL29 family
HUI95_01005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUI95_01010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUI95_01015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUI95_01020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUI95_01025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUI95_01030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUI95_01035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUI95_01040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUI95_01045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUI95_01050	COG1841	ribosomal large subunit assembly
HUI95_01055	COG0200	Binds to the 23S rRNA
HUI95_01060	COG0201	protein transport
HUI95_01065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUI95_01070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUI95_01075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUI95_01080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUI95_01085	COG0202	RNA polymerase activity
HUI95_01090	COG0203	ribosomal protein L17
HUI95_01140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUI95_01145	COG0583	DNA-binding transcription factor activity
HUI95_01150	COG4221	oxidoreductase activity
HUI95_01165	COG1770	oligopeptidase
HUI95_01170	COG2358	TRAP transporter, solute receptor (TAXI family
HUI95_01185	COG3714	YhhN family
HUI95_01210	COG1301	dicarboxylic acid transport
HUI95_01220	COG2095	MarC family integral membrane protein
HUI95_01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUI95_01240	COG0741	lytic transglycosylase activity
HUI95_01250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUI95_01275	COG0742	ribosomal rna small subunit methyltransferase
HUI95_01280	COG0552	protein localization to endoplasmic reticulum
HUI95_01285	COG2884	Cell division ATP-binding protein ftsE
HUI95_01290	COG2177	Part of the ABC transporter FtsEX involved in
HUI95_01300	COG0288	reversible hydration of carbon dioxide
HUI95_01305	COG2188	Transcriptional regulator
HUI95_01310	COG1228	amidohydrolase
HUI95_01315	COG0010	Belongs to the arginase family
HUI95_01320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUI95_01325	COG2986	histidine ammonia-lyase
HUI95_01330	COG0387	Pfam Sodium calcium exchanger
HUI95_01335	COG2200	EAL domain
HUI95_01340	COG2199	diguanylate cyclase activity
HUI95_01340	COG2200	EAL domain
HUI95_01385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUI95_01390	COG1459	type II secretion system
HUI95_01400	COG2165	general secretion pathway protein
HUI95_01435	COG1077	Cell shape determining protein MreB Mrl
HUI95_01440	COG1792	Involved in formation and maintenance of cell shape
HUI95_01445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HUI95_01450	COG0424	maF-like protein
HUI95_01455	COG1530	ribonuclease E activity
HUI95_01460	COG3164	Protein of unknown function
HUI95_01470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUI95_01475	COG0312	modulator of DNA gyrase
HUI95_01490	COG0477	Major facilitator Superfamily
HUI95_01500	COG3437	response regulator, receiver
HUI95_01505	COG0784	Response regulator, receiver
HUI95_01505	COG2205	protein histidine kinase activity
HUI95_01505	COG5002	protein histidine kinase activity
HUI95_01510	COG2172	sigma factor antagonist activity
HUI95_01515	COG1366	Belongs to the anti-sigma-factor antagonist family
HUI95_01535	COG3700	Belongs to the class B bacterial acid phosphatase family
HUI95_01540	COG2321	neutral zinc metallopeptidase
HUI95_01550	COG1639	'signal transduction protein
HUI95_01580	COG0189	ligase activity
HUI95_01585	COG0642	Histidine kinase
HUI95_01590	COG0745	RESPONSE REGULATOR receiver
HUI95_01615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUI95_01620	COG0352	thiamine-phosphate diphosphorylase activity
HUI95_01625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUI95_01635	COG2022	thiamine diphosphate biosynthetic process
HUI95_01640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUI95_01645	COG1943	Transposase
HUI95_01665	COG0110	maltose O-acetyltransferase activity
HUI95_01670	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HUI95_01695	COG0814	amino acid
HUI95_01700	COG3932	Exopolysaccharide synthesis, ExoD
HUI95_01725	COG0456	acetyltransferase
HUI95_01760	COG1494	fructose-1,6-bisphosphatase
HUI95_01775	COG2959	enzyme of heme biosynthesis
HUI95_01785	COG0181	hydroxymethylbilane synthase activity
HUI95_01790	COG3072	Adenylate cyclase
HUI95_01795	COG0400	carboxylic ester hydrolase activity
HUI95_01800	COG1965	Belongs to the frataxin family
HUI95_01810	COG0019	diaminopimelate decarboxylase activity
HUI95_01815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUI95_01830	COG1011	Hydrolase
HUI95_01850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUI95_01855	COG0561	phosphatase activity
HUI95_01870	COG1129	ABC transporter
HUI95_01870	COG0842	Transport permease protein
HUI95_01880	COG1058	Belongs to the CinA family
HUI95_01880	COG1546	Belongs to the CinA family
HUI95_01885	COG1418	mRNA catabolic process
HUI95_01890	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HUI95_01900	COG1522	sequence-specific DNA binding
HUI95_01905	COG1368	sulfuric ester hydrolase activity
HUI95_01925	COG1285	pathogenesis
HUI95_01945	COG4221	oxidoreductase activity
HUI95_01960	COG1979	alcohol dehydrogenase
HUI95_01970	COG2873	o-acetylhomoserine
HUI95_01995	COG5380	lipid catabolic process
HUI95_02000	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUI95_02010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUI95_02015	COG2949	membrane
HUI95_02020	COG3291	Pkd domain containing protein
HUI95_02030	COG3539	Fimbrial protein
HUI95_02040	COG3188	usher protein
HUI95_02045	COG3121	Chaperone
HUI95_02065	COG0318	PFAM AMP-dependent synthetase and ligase
HUI95_02070	COG1441	menaquinone biosynthetic process
HUI95_02075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUI95_02080	COG0596	Alpha beta hydrolase
HUI95_02085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUI95_02090	COG1169	isochorismate synthase
HUI95_02095	COG1575	Belongs to the MenA family. Type 1 subfamily
HUI95_02120	COG0513	Belongs to the DEAD box helicase family
HUI95_02125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUI95_02130	COG1988	membrane-bound metal-dependent
HUI95_02145	COG1671	Belongs to the UPF0178 family
HUI95_02175	COG3722	fumarate hydratase activity
HUI95_02180	COG0246	Mannitol dehydrogenase
HUI95_02185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_02185	COG2213	PTS system mannitol-specific
HUI95_02195	COG1309	transcriptional regulator
HUI95_02200	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HUI95_02210	COG3916	Acyl-homoserine-lactone synthase
HUI95_02215	COG2771	luxR family
HUI95_02230	COG3133	Outer membrane lipoprotein
HUI95_02235	COG0456	acetyltransferase
HUI95_02255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HUI95_02260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUI95_02270	COG3031	protein transport across the cell outer membrane
HUI95_02280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUI95_02285	COG1459	type II secretion system
HUI95_02290	COG2165	general secretion pathway protein
HUI95_02300	COG2165	general secretion pathway protein
HUI95_02305	COG4795	General secretion pathway protein
HUI95_02310	COG3156	type II secretion system protein K
HUI95_02320	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HUI95_02335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUI95_02345	COG1902	pentaerythritol trinitrate reductase activity
HUI95_02350	COG1011	Hydrolase
HUI95_02355	COG0494	nUDIX hydrolase
HUI95_02360	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUI95_02365	COG0814	amino acid
HUI95_02370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUI95_02375	COG2207	Transcriptional regulator
HUI95_02375	COG3708	Transcriptional regulator
HUI95_02385	COG0626	cystathionine gamma-synthase activity
HUI95_02390	COG0527	aspartate kinase activity
HUI95_02390	COG0460	homoserine dehydrogenase
HUI95_02395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUI95_02405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUI95_02410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUI95_02420	COG0137	argininosuccinate synthase activity
HUI95_02425	COG0165	Argininosuccinate lyase
HUI95_02450	COG0110	maltose O-acetyltransferase activity
HUI95_02455	COG3174	membrane
HUI95_02460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUI95_02470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HUI95_02475	COG4208	sulfate ABC transporter
HUI95_02480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUI95_02485	COG0583	DNA-binding transcription factor activity
HUI95_02490	COG3397	chitin binding
HUI95_02525	COG4946	Tricorn protease homolog
HUI95_02525	COG0793	Belongs to the peptidase S41A family
HUI95_02545	COG1328	CTP reductase activity
HUI95_02550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUI95_02565	COG1448	Aminotransferase
HUI95_02605	COG0513	Belongs to the DEAD box helicase family
HUI95_02635	COG3112	Uncharacterised protein family (UPF0231)
HUI95_02640	COG3835	regulator
HUI95_02645	COG2610	gluconate transmembrane transporter activity
HUI95_02650	COG1929	Belongs to the glycerate kinase type-1 family
HUI95_02665	COG0583	DNA-binding transcription factor activity
HUI95_02670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUI95_02685	COG0347	Belongs to the P(II) protein family
HUI95_02690	COG1840	ABC-type Fe3 transport system, periplasmic component
HUI95_02700	COG3842	ATPase activity
HUI95_02705	COG2837	iron assimilation
HUI95_02710	COG1438	arginine binding
HUI95_02715	COG1126	abc transporter atp-binding protein
HUI95_02720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_02725	COG4215	(ABC) transporter
HUI95_02730	COG4160	amino acid transport
HUI95_02735	COG0039	L-malate dehydrogenase activity
HUI95_02740	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HUI95_02745	COG1017	nitric oxide dioxygenase activity
HUI95_02745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUI95_02750	COG1959	2 iron, 2 sulfur cluster binding
HUI95_02755	COG4536	flavin adenine dinucleotide binding
HUI95_02760	COG4137	Cytochrome C assembly protein
HUI95_02765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUI95_02770	COG0228	four-way junction DNA binding
HUI95_02775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUI95_02780	COG0336	Belongs to the RNA methyltransferase TrmD family
HUI95_02785	COG0335	large ribosomal subunit rRNA binding
HUI95_02795	COG3066	DNA modification
HUI95_02800	COG1051	belongs to the nudix hydrolase family
HUI95_02810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUI95_02815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUI95_02820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUI95_02830	COG0583	DNA-binding transcription factor activity
HUI95_02835	COG0640	Transcriptional regulator
HUI95_02840	COG0268	Binds directly to 16S ribosomal RNA
HUI95_02845	COG0728	peptidoglycan biosynthetic process
HUI95_02850	COG0196	riboflavin kinase activity
HUI95_02855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUI95_02860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUI95_02865	COG1047	Peptidyl-prolyl cis-trans
HUI95_02870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUI95_02875	COG4970	Tfp pilus assembly protein FimT
HUI95_02930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUI95_02930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUI95_02945	COG1854	S-ribosylhomocysteine lyase activity
HUI95_02950	COG3706	GGDEF domain
HUI95_02955	COG0557	exoribonuclease II activity
HUI95_02970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUI95_02985	COG2153	protein acetylation
HUI95_02990	COG0697	spore germination
HUI95_03010	COG2814	Major facilitator Superfamily
HUI95_03020	COG0583	DNA-binding transcription factor activity
HUI95_03030	COG1914	H( )-stimulated, divalent metal cation uptake system
HUI95_03035	COG0360	Binds together with S18 to 16S ribosomal RNA
HUI95_03040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUI95_03045	COG0359	binds to the 23S rRNA
HUI95_03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUI95_03075	COG1064	alcohol dehydrogenase
HUI95_03080	COG1238	metal cluster binding
HUI95_03085	COG0612	Peptidase, M16
HUI95_03090	COG2918	glutathione biosynthetic process
HUI95_03095	COG1022	Amp-dependent synthetase and ligase
HUI95_03105	COG0456	acetyltransferase
HUI95_03115	COG2801	Transposase and inactivated derivatives
HUI95_03140	COG5001	Diguanylate cyclase
HUI95_03165	COG1902	pentaerythritol trinitrate reductase activity
HUI95_03175	COG2852	Protein conserved in bacteria
HUI95_03185	COG2957	Belongs to the agmatine deiminase family
HUI95_03190	COG0154	amidase activity
HUI95_03210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUI95_03215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUI95_03225	COG0513	Belongs to the DEAD box helicase family
HUI95_03245	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HUI95_03250	COG1858	cytochrome C peroxidase
HUI95_03275	COG2070	2-Nitropropane dioxygenase
HUI95_03315	COG2205	protein histidine kinase activity
HUI95_03320	COG0745	RESPONSE REGULATOR receiver
HUI95_03325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_03330	COG0577	efflux transmembrane transporter activity
HUI95_03330	COG1136	(ABC) transporter
HUI95_03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_03340	COG1126	abc transporter atp-binding protein
HUI95_03345	COG0765	amino acid transport
HUI95_03350	COG0765	amino acid transport
HUI95_03355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUI95_03360	COG1505	serine-type exopeptidase activity
HUI95_03365	COG2982	Protein involved in outer membrane biogenesis
HUI95_03375	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_03380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUI95_03395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUI95_03400	COG4991	sh3 domain protein
HUI95_03415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUI95_03420	COG1940	carbohydrate kinase activity
HUI95_03425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUI95_03430	COG0126	phosphoglycerate kinase activity
HUI95_03440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUI95_03485	COG0354	folic acid binding
HUI95_03490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HUI95_03500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUI95_03505	COG1595	DNA-templated transcription, initiation
HUI95_03510	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HUI95_03525	COG0481	GTPase activity
HUI95_03530	COG0681	Belongs to the peptidase S26 family
HUI95_03535	COG0571	ribonuclease III activity
HUI95_03545	COG1381	Involved in DNA repair and RecF pathway recombination
HUI95_03550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUI95_03560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUI95_03565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_03570	COG3716	PTS system mannose fructose sorbose family IID component
HUI95_03580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUI95_03585	COG2222	sugar isomerase
HUI95_03595	COG1349	DNA-binding transcription factor activity
HUI95_03600	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUI95_03605	COG4807	Protein conserved in bacteria
HUI95_03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUI95_03620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUI95_03625	COG3956	TIGRFAM MazG family protein
HUI95_03630	COG0504	CTP synthase activity
HUI95_03635	COG0148	phosphopyruvate hydratase activity
HUI95_03640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HUI95_03645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUI95_03655	COG0585	pseudouridine synthase activity
HUI95_03660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUI95_03665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUI95_03670	COG1238	metal cluster binding
HUI95_03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUI95_03690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUI95_03695	COG1610	YqeY-like protein
HUI95_03700	COG0358	DNA primase activity
HUI95_03705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUI95_03730	COG0138	bifunctional purine biosynthesis protein purh
HUI95_03740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUI95_03745	COG3036	rescue of stalled ribosome
HUI95_03750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUI95_03755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUI95_03765	COG0673	inositol 2-dehydrogenase activity
HUI95_03775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUI95_03780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUI95_03785	COG3227	Zinc metalloprotease (Elastase)
HUI95_03795	COG0477	Major facilitator Superfamily
HUI95_03805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HUI95_03810	COG1027	Aspartate ammonia-lyase
HUI95_03815	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUI95_03820	COG0534	Mate efflux family protein
HUI95_03825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUI95_03830	COG0459	protein refolding
HUI95_03850	COG0564	pseudouridine synthase activity
HUI95_03855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUI95_03890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HUI95_03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_03935	COG0745	RESPONSE REGULATOR receiver
HUI95_03940	COG3104	oligopeptide transport
HUI95_03945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUI95_03950	COG1555	photosystem II stabilization
HUI95_03960	COG2350	Protein conserved in bacteria
HUI95_03965	COG2917	probably involved in intracellular septation
HUI95_03970	COG0076	glutamate decarboxylase activity
HUI95_03975	COG1272	protein, Hemolysin III
HUI95_03980	COG2985	domain, Protein
HUI95_03980	COG0569	domain protein
HUI95_03990	COG0784	Response regulator, receiver
HUI95_03990	COG0835	chemotaxis
HUI95_03995	COG2755	lipolytic protein G-D-S-L family
HUI95_04000	COG4181	ATPase activity
HUI95_04005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HUI95_04010	COG1090	epimerase
HUI95_04015	COG2200	EAL domain
HUI95_04020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUI95_04025	COG4935	Belongs to the peptidase S8 family
HUI95_04025	COG2234	aminopeptidase activity
HUI95_04030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUI95_04035	COG3171	Protein conserved in bacteria
HUI95_04040	COG2066	Belongs to the glutaminase family
HUI95_04045	COG2897	thiosulfate sulfurtransferase activity
HUI95_04060	COG1132	(ABC) transporter
HUI95_04085	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HUI95_04090	COG3300	MHYT domain
HUI95_04090	COG5001	Diguanylate cyclase
HUI95_04110	COG4628	conserved protein (DUF2132)
HUI95_04115	COG0688	phosphatidylethanolamine metabolic process
HUI95_04120	COG1162	GTPase activity
HUI95_04125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUI95_04165	COG1278	Cold shock
HUI95_04175	COG0840	transmembrane signaling receptor activity
HUI95_04180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUI95_04230	COG0848	biopolymer transport protein
HUI95_04235	COG0811	peptide transport
HUI95_04240	COG0811	peptide transport
HUI95_04255	COG4174	ABC transporter (Permease)
HUI95_04260	COG4239	(ABC) transporter, permease
HUI95_04270	COG0444	Belongs to the ABC transporter superfamily
HUI95_04275	COG4608	Belongs to the ABC transporter superfamily
HUI95_04280	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUI95_04285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUI95_04290	COG1073	alpha beta
HUI95_04305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUI95_04335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUI95_04340	COG2313	pseudouridylate synthase activity
HUI95_04350	COG1858	cytochrome C peroxidase
HUI95_04385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUI95_04390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUI95_04405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUI95_04415	COG2986	histidine ammonia-lyase
HUI95_04440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUI95_04450	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_04455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUI95_04465	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUI95_04475	COG2966	Psort location CytoplasmicMembrane, score
HUI95_04480	COG3610	response to peptide
HUI95_04500	COG4175	Glycine betaine
HUI95_04505	COG4176	ABC-type proline glycine betaine transport system permease component
HUI95_04510	COG2113	Glycine betaine
HUI95_04515	COG0175	sulfate reduction
HUI95_04520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUI95_04525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUI95_04530	COG0384	phenazine biosynthesis protein PhzF
HUI95_04535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUI95_04550	COG0786	glutamate:sodium symporter activity
HUI95_04555	COG0252	asparaginase activity
HUI95_04560	COG3139	Protein of unknown function (DUF1315)
HUI95_04580	COG0616	signal peptide processing
HUI95_04585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUI95_04585	COG1902	pentaerythritol trinitrate reductase activity
HUI95_04590	COG0778	Nitroreductase
HUI95_04605	COG2264	protein methyltransferase activity
HUI95_04610	COG0604	alcohol dehydrogenase
HUI95_04615	COG0583	DNA-binding transcription factor activity
HUI95_04620	COG1263	PTS System
HUI95_04620	COG2190	(PTS) system
HUI95_04620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUI95_04625	COG4145	pantothenate transmembrane transporter activity
HUI95_04630	COG3924	membrane
HUI95_04635	COG0439	Biotin carboxylase
HUI95_04640	COG0511	ligase activity, forming carbon-carbon bonds
HUI95_04645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUI95_04650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUI95_04660	COG3300	MHYT domain
HUI95_04660	COG5001	Diguanylate cyclase
HUI95_04680	COG3381	protein complex oligomerization
HUI95_04690	COG3005	denitrification pathway
HUI95_04695	COG0745	RESPONSE REGULATOR receiver
HUI95_04705	COG1879	ABC-type sugar transport system periplasmic component
HUI95_04710	COG0784	Response regulator, receiver
HUI95_04710	COG2198	Histidine kinase
HUI95_04710	COG2205	protein histidine kinase activity
HUI95_04720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUI95_04735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUI95_04740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUI95_04740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUI95_04755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUI95_04760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUI95_04765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUI95_04770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUI95_04775	COG4172	Belongs to the ABC transporter superfamily
HUI95_04785	COG0601	transmembrane transport
HUI95_04790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUI95_04795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUI95_04800	COG0142	geranyltranstransferase activity
HUI95_04805	COG1722	exodeoxyribonuclease VII activity
HUI95_04810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUI95_04815	COG1360	Flagellar Motor Protein
HUI95_04830	COG1534	Rna-binding protein
HUI95_04835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HUI95_04845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUI95_04850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUI95_04855	COG0149	triose-phosphate isomerase activity
HUI95_04860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUI95_04875	COG0779	Required for maturation of 30S ribosomal subunits
HUI95_04880	COG0195	Participates in both transcription termination and antitermination
HUI95_04885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUI95_04890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUI95_04895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUI95_04900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUI95_04905	COG1185	polyribonucleotide nucleotidyltransferase activity
HUI95_04910	COG2211	Major facilitator Superfamily
HUI95_04915	COG3706	GGDEF domain
HUI95_04920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HUI95_04930	COG0114	fumarate hydratase activity
HUI95_05000	COG0312	modulator of DNA gyrase
HUI95_05005	COG0312	modulator of DNA gyrase
HUI95_05015	COG4974	Belongs to the 'phage' integrase family
HUI95_05025	COG1970	mechanosensitive ion channel activity
HUI95_05035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUI95_05040	COG0789	Transcriptional regulator
HUI95_05060	COG3545	Serine hydrolase
HUI95_05065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUI95_05070	COG0321	lipoyl(octanoyl) transferase activity
HUI95_05075	COG2921	Belongs to the UPF0250 family
HUI95_05080	COG1686	Belongs to the peptidase S11 family
HUI95_05090	COG2951	lytic endotransglycosylase activity
HUI95_05095	COG0772	Belongs to the SEDS family
HUI95_05100	COG0768	penicillin binding
HUI95_05105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUI95_05110	COG0799	negative regulation of ribosome biogenesis
HUI95_05115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUI95_05130	COG0495	leucyl-tRNA aminoacylation
HUI95_05135	COG2888	peptidyl-tyrosine sulfation
HUI95_05140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUI95_05145	COG4535	Mg2 and Co2 transporter CorC
HUI95_05150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUI95_05155	COG1702	phosphate starvation-inducible protein PhoH
HUI95_05160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUI95_05165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUI95_05170	COG1335	isochorismatase
HUI95_05180	COG3706	GGDEF domain
HUI95_05195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUI95_05215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUI95_05225	COG3647	Membrane
HUI95_05230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUI95_05240	COG0516	GMP reductase activity
HUI95_05250	COG0642	Histidine kinase
HUI95_05290	COG3214	Protein conserved in bacteria
HUI95_05315	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HUI95_05320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUI95_05325	COG1053	succinate dehydrogenase
HUI95_05335	COG0584	glycerophosphoryl diester phosphodiesterase
HUI95_05340	COG3264	Mechanosensitive ion channel
HUI95_05340	COG1511	domain protein
HUI95_05350	COG0739	heme binding
HUI95_05365	COG0583	DNA-binding transcription factor activity
HUI95_05385	COG0583	DNA-binding transcription factor activity
HUI95_05390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUI95_05420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUI95_05425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUI95_05435	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HUI95_05445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUI95_05455	COG0180	Tryptophanyl-tRNA synthetase
HUI95_05470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUI95_05480	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUI95_05500	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUI95_05500	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUI95_05500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUI95_05500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_05530	COG0488	(ABC) transporter
HUI95_05540	COG0366	Alpha amylase catalytic
HUI95_05550	COG3097	Belongs to the UPF0267 family
HUI95_05560	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HUI95_05570	COG0490	domain, Protein
HUI95_05570	COG0471	metal ion transport
HUI95_05615	COG0012	GTP binding
HUI95_05620	COG0193	aminoacyl-tRNA hydrolase activity
HUI95_05625	COG0737	Belongs to the 5'-nucleotidase family
HUI95_05630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUI95_05640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUI95_05645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HUI95_05650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUI95_05655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUI95_05660	COG2890	protein-(glutamine-N5) methyltransferase activity
HUI95_05670	COG2912	Transglutaminase-like superfamily
HUI95_05675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUI95_05680	COG1301	dicarboxylic acid transport
HUI95_05690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUI95_05705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUI95_05710	COG1115	amino acid carrier protein
HUI95_05725	COG0714	Associated with various cellular activities
HUI95_05735	COG3104	oligopeptide transport
HUI95_05740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUI95_05745	COG1678	Uncharacterized ACR, COG1678
HUI95_05755	COG0189	ligase activity
HUI95_05760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUI95_05770	COG3091	SprT-like family
HUI95_05780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUI95_05795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUI95_05800	COG0739	heme binding
HUI95_05805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUI95_05810	COG3408	Glycogen debranching enzyme
HUI95_05810	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HUI95_05820	COG1881	PFAM PEBP family protein
HUI95_05825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUI95_05830	COG0583	DNA-binding transcription factor activity
HUI95_05840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUI95_05850	COG0583	DNA-binding transcription factor activity
HUI95_05855	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_05860	COG0616	signal peptide processing
HUI95_05865	COG3724	N-succinylarginine dihydrolase activity
HUI95_05885	COG0840	transmembrane signaling receptor activity
HUI95_05895	COG2971	BadF BadG BcrA BcrD
HUI95_05905	COG4608	Belongs to the ABC transporter superfamily
HUI95_05910	COG0444	Belongs to the ABC transporter superfamily
HUI95_05915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUI95_05920	COG0601	transmembrane transport
HUI95_05925	COG4166	transmembrane transport
HUI95_05930	COG0784	Response regulator, receiver
HUI95_05930	COG2205	protein histidine kinase activity
HUI95_05970	COG3220	belongs to the UPF0276 family
HUI95_06000	COG1289	transmembrane transporter activity
HUI95_06005	COG0303	'Molybdopterin
HUI95_06010	COG0746	molybdenum cofactor guanylyltransferase activity
HUI95_06020	COG4662	Binding-protein-dependent transport system inner membrane component
HUI95_06030	COG2204	response regulator
HUI95_06035	COG3852	Histidine kinase
HUI95_06040	COG1910	domain protein
HUI95_06045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUI95_06080	COG3383	formate dehydrogenase (NAD+) activity
HUI95_06080	COG3383	formate dehydrogenase (NAD+) activity
HUI95_06085	COG0437	4 iron, 4 sulfur cluster binding
HUI95_06095	COG0281	malic enzyme
HUI95_06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_06130	COG2706	6-phosphogluconolactonase activity
HUI95_06140	COG3264	Mechanosensitive ion channel
HUI95_06140	COG1196	nuclear chromosome segregation
HUI95_06145	COG0469	pyruvate kinase activity
HUI95_06155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUI95_06155	COG4651	solute:proton antiporter activity
HUI95_06165	COG2974	May be involved in recombination
HUI95_06175	COG0420	3'-5' exonuclease activity
HUI95_06185	COG3038	cytochrome b561
HUI95_06195	COG2190	(PTS) system
HUI95_06200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUI95_06205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_06210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUI95_06215	COG0542	response to heat
HUI95_06230	COG2770	Histidine kinase
HUI95_06230	COG3437	response regulator, receiver
HUI95_06235	COG1720	tRNA m6t6A37 methyltransferase activity
HUI95_06255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUI95_06260	COG4988	ABC transporter
HUI95_06275	COG0745	RESPONSE REGULATOR receiver
HUI95_06285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUI95_06300	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HUI95_06305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HUI95_06315	COG0083	homoserine kinase activity
HUI95_06320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUI95_06335	COG0813	purine-nucleoside phosphorylase activity
HUI95_06350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_06350	COG2205	protein histidine kinase activity
HUI95_06355	COG5001	Diguanylate cyclase
HUI95_06355	COG4251	negative regulation of phosphorylation
HUI95_06355	COG2203	Gaf domain
HUI95_06355	COG3706	GGDEF domain
HUI95_06360	COG2205	protein histidine kinase activity
HUI95_06360	COG0784	Response regulator, receiver
HUI95_06360	COG5002	protein histidine kinase activity
HUI95_06365	COG3384	dioxygenase
HUI95_06375	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUI95_06385	COG0531	amino acid
HUI95_06395	COG0531	amino acid
HUI95_06410	COG1396	sequence-specific DNA binding
HUI95_06410	COG1917	Cupin 2, conserved barrel domain protein
HUI95_06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUI95_06435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUI95_06440	COG2375	cellular response to nickel ion
HUI95_06450	COG0577	efflux transmembrane transporter activity
HUI95_06450	COG1136	(ABC) transporter
HUI95_06455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_06465	COG1227	inorganic diphosphatase activity
HUI95_06470	COG0497	DNA recombination
HUI95_06475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUI95_06480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUI95_06485	COG0443	Heat shock 70 kDa protein
HUI95_06490	COG0484	heat shock protein binding
HUI95_06520	COG1285	pathogenesis
HUI95_06535	COG0640	Transcriptional regulator
HUI95_06565	COG0095	Lipoate-protein ligase
HUI95_06580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUI95_06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_06610	COG0708	Exodeoxyribonuclease III
HUI95_06625	COG0071	Belongs to the small heat shock protein (HSP20) family
HUI95_06630	COG2211	Major facilitator Superfamily
HUI95_06670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUI95_06675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUI95_06680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUI95_06685	COG1845	cytochrome c oxidase, subunit III
HUI95_06690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUI95_06695	COG0109	protoheme IX farnesyltransferase activity
HUI95_06700	COG2814	Major facilitator Superfamily
HUI95_06710	COG2175	clavaminate synthase activity
HUI95_06715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUI95_06720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUI95_06725	COG4521	taurine ABC transporter
HUI95_06735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUI95_06765	COG3621	Patatin-like phospholipase
HUI95_06775	COG0159	tryptophan synthase activity
HUI95_06780	COG0133	tryptophan synthase activity
HUI95_06785	COG0134	indole-3-glycerol-phosphate synthase activity
HUI95_06785	COG0135	phosphoribosylanthranilate isomerase activity
HUI95_06790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUI95_06795	COG0512	Glutamine amidotransferase of anthranilate synthase
HUI95_06795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUI95_06800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUI95_06810	COG0009	L-threonylcarbamoyladenylate synthase
HUI95_06820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUI95_06830	COG1946	Acyl-CoA thioesterase
HUI95_06850	COG1309	transcriptional regulator
HUI95_06855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUI95_06860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUI95_06875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUI95_06900	COG0110	maltose O-acetyltransferase activity
HUI95_06920	COG0110	maltose O-acetyltransferase activity
HUI95_06940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUI95_06960	COG3132	Protein of unknown function, DUF480
HUI95_06980	COG2988	succinylglutamate desuccinylase activity
HUI95_07000	COG1278	Cold shock
HUI95_07025	COG4166	transmembrane transport
HUI95_07030	COG0697	spore germination
HUI95_07035	COG1349	DNA-binding transcription factor activity
HUI95_07040	COG1882	Formate acetyltransferase
HUI95_07045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUI95_07050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUI95_07075	COG4166	transmembrane transport
HUI95_07080	COG0622	Phosphoesterase
HUI95_07095	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HUI95_07100	COG0784	Response regulator, receiver
HUI95_07100	COG0835	chemotaxis
HUI95_07105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUI95_07110	COG1815	bacterial-type flagellum-dependent cell motility
HUI95_07130	COG4787	bacterial-type flagellum-dependent cell motility
HUI95_07140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUI95_07145	COG1706	bacterial-type flagellum-dependent cell motility
HUI95_07150	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUI95_07150	COG3951	Flagellar rod assembly protein muramidase FlgJ
HUI95_07155	COG1256	bacterial-type flagellum assembly
HUI95_07165	COG2239	Acts as a magnesium transporter
HUI95_07175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUI95_07180	COG2716	regulation of RNA biosynthetic process
HUI95_07205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUI95_07210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUI95_07215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUI95_07220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUI95_07240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUI95_07255	COG0590	tRNA wobble adenosine to inosine editing
HUI95_07260	COG0573	inorganic phosphate transmembrane transporter activity
HUI95_07265	COG0581	inorganic phosphate transmembrane transporter activity
HUI95_07270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUI95_07275	COG0704	Plays a role in the regulation of phosphate uptake
HUI95_07280	COG1253	flavin adenine dinucleotide binding
HUI95_07295	COG0531	amino acid
HUI95_07320	COG0765	amino acid transport
HUI95_07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_07330	COG2271	Major facilitator Superfamily
HUI95_07345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUI95_07370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUI95_07375	COG0477	Major facilitator Superfamily
HUI95_07380	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUI95_07390	COG1199	ATP-dependent helicase activity
HUI95_07405	COG1448	Aminotransferase
HUI95_07410	COG0433	COG0433 Predicted ATPase
HUI95_07425	COG0658	competence protein
HUI95_07425	COG2333	competence protein COMEC
HUI95_07435	COG1663	tetraacyldisaccharide 4'-kinase activity
HUI95_07440	COG2835	tetraacyldisaccharide 4'-kinase activity
HUI95_07445	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUI95_07450	COG2197	response regulator
HUI95_07455	COG0322	excinuclease ABC activity
HUI95_07505	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HUI95_07510	COG0437	4 iron, 4 sulfur cluster binding
HUI95_07515	COG3301	Polysulphide reductase, NrfD
HUI95_07520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUI95_07530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUI95_07545	COG2199	diguanylate cyclase activity
HUI95_07545	COG2203	Gaf domain
HUI95_07575	COG2119	membrane
HUI95_07580	COG0023	Translation Initiation Factor
HUI95_07620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_07620	COG2205	protein histidine kinase activity
HUI95_07630	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HUI95_07635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUI95_07640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUI95_07645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUI95_07650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUI95_07655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUI95_07665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUI95_07670	COG0505	Belongs to the CarA family
HUI95_07675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUI95_07680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUI95_07695	COG2814	Major facilitator Superfamily
HUI95_07735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUI95_07740	COG0513	Belongs to the DEAD box helicase family
HUI95_07750	COG4104	PAAR repeat-containing protein
HUI95_07765	COG0789	Transcriptional regulator
HUI95_07780	COG0493	'glutamate synthase
HUI95_07785	COG0067	glutamate synthase
HUI95_07785	COG0069	glutamate synthase activity
HUI95_07785	COG0070	glutamate synthase
HUI95_07790	COG1242	4 iron, 4 sulfur cluster binding
HUI95_07845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HUI95_07850	COG0574	Belongs to the PEP-utilizing enzyme family
HUI95_07850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUI95_07895	COG1464	Belongs to the NlpA lipoprotein family
HUI95_07900	COG0671	phosphoesterase, PA-phosphatase related
HUI95_07905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUI95_07910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUI95_07920	COG0101	tRNA pseudouridine synthase activity
HUI95_07925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUI95_07930	COG0285	dihydrofolate synthase activity
HUI95_07935	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HUI95_07940	COG2920	part of a sulfur-relay system
HUI95_07945	COG1289	transmembrane transporter activity
HUI95_07950	COG0670	Belongs to the BI1 family
HUI95_07970	COG2194	sulfuric ester hydrolase activity
HUI95_07975	COG0392	lysyltransferase activity
HUI95_07975	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUI95_07985	COG0840	transmembrane signaling receptor activity
HUI95_07990	COG5001	Diguanylate cyclase
HUI95_07995	COG0564	pseudouridine synthase activity
HUI95_08010	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUI95_08020	COG0625	glutathione transferase activity
HUI95_08030	COG0367	asparagine synthase
HUI95_08040	COG4651	solute:proton antiporter activity
HUI95_08040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUI95_08045	COG0647	UMP catabolic process
HUI95_08050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUI95_08055	COG1902	pentaerythritol trinitrate reductase activity
HUI95_08060	COG1253	flavin adenine dinucleotide binding
HUI95_08070	COG0247	lactate metabolic process
HUI95_08070	COG0277	FAD linked oxidase domain protein
HUI95_08080	COG2050	protein possibly involved in aromatic compounds catabolism
HUI95_08090	COG2056	Na+-H+ antiporter family
HUI95_08095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUI95_08110	COG0346	lactoylglutathione lyase activity
HUI95_08115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUI95_08120	COG4660	Part of a membrane complex involved in electron transport
HUI95_08125	COG4659	FMN binding
HUI95_08130	COG4658	electron transport chain
HUI95_08140	COG2878	Part of a membrane complex involved in electron transport
HUI95_08145	COG4657	Part of a membrane complex involved in electron transport
HUI95_08150	COG0697	spore germination
HUI95_08160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUI95_08165	COG1288	antiporter activity
HUI95_08170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HUI95_08170	COG3264	Mechanosensitive ion channel
HUI95_08175	COG0436	Aminotransferase
HUI95_08185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUI95_08190	COG2027	D-alanyl-D-alanine carboxypeptidase
HUI95_08195	COG1061	Type III restriction enzyme res subunit
HUI95_08200	COG1566	PFAM secretion protein HlyD family protein
HUI95_08210	COG1966	Carbon starvation protein
HUI95_08215	COG3279	Response regulator of the LytR AlgR family
HUI95_08220	COG3275	phosphorelay sensor kinase activity
HUI95_08225	COG2199	diguanylate cyclase activity
HUI95_08225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUI95_08230	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_08230	COG1454	alcohol dehydrogenase
HUI95_08240	COG2095	MarC family integral membrane protein
HUI95_08250	COG0601	transmembrane transport
HUI95_08255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUI95_08260	COG0444	Belongs to the ABC transporter superfamily
HUI95_08270	COG0861	Integral membrane protein TerC family
HUI95_08275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUI95_08285	COG1301	dicarboxylic acid transport
HUI95_08300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUI95_08315	COG0537	adenosine 5'-monophosphoramidase activity
HUI95_08350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUI95_08355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUI95_08375	COG2354	Protein conserved in bacteria
HUI95_08390	COG2233	PERMEase
HUI95_08395	COG3150	esterase
HUI95_08400	COG1252	NADH dehydrogenase
HUI95_08420	COG0393	Putative heavy-metal-binding
HUI95_08430	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUI95_08435	COG1368	sulfuric ester hydrolase activity
HUI95_08445	COG0527	aspartate kinase activity
HUI95_08450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUI95_08450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUI95_08455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUI95_08475	COG0596	Alpha beta hydrolase
HUI95_08480	COG0583	DNA-binding transcription factor activity
HUI95_08485	COG1620	l-lactate permease
HUI95_08490	COG0247	lactate metabolic process
HUI95_08495	COG1139	Iron-sulfur cluster binding protein
HUI95_08510	COG2801	Transposase and inactivated derivatives
HUI95_08535	COG0577	efflux transmembrane transporter activity
HUI95_08540	COG1136	(ABC) transporter
HUI95_08560	COG2814	Major facilitator Superfamily
HUI95_08580	COG0672	)-iron permease
HUI95_08610	COG0659	secondary active sulfate transmembrane transporter activity
HUI95_08620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUI95_08630	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HUI95_08635	COG0437	4 iron, 4 sulfur cluster binding
HUI95_08640	COG5557	Pfam Polysulphide reductase, NrfD
HUI95_08645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HUI95_08650	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HUI95_08655	COG1773	rubredoxin
HUI95_08670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUI95_08680	COG1124	(ABC) transporter
HUI95_08685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUI95_08690	COG0375	protein maturation
HUI95_08695	COG0309	Hydrogenase expression formation protein (HypE)
HUI95_08705	COG0298	carbon dioxide binding
HUI95_08710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HUI95_08720	COG1921	L-seryl-tRNASec selenium transferase activity
HUI95_08730	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HUI95_08740	COG3260	NADH ubiquinone oxidoreductase 20
HUI95_08745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_08750	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HUI95_08750	COG3261	NADH dehydrogenase
HUI95_08755	COG0650	Formate hydrogenlyase subunit 4
HUI95_08760	COG0651	ATP synthesis coupled electron transport
HUI95_08765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_08770	COG3158	transport of potassium into the cell
HUI95_08780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_08805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUI95_08810	COG0326	Molecular chaperone. Has ATPase activity
HUI95_08815	COG0563	adenylate kinase activity
HUI95_08820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUI95_08825	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HUI95_08830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUI95_08845	COG3300	MHYT domain
HUI95_08845	COG5001	Diguanylate cyclase
HUI95_08850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUI95_08870	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUI95_08875	COG1535	isochorismatase
HUI95_08875	COG3433	isochorismatase activity
HUI95_08880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUI95_08885	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUI95_08900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUI95_08905	COG2977	Belongs to the P-Pant transferase superfamily
HUI95_08910	COG1120	ATPase activity
HUI95_08915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUI95_08920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUI95_08925	COG4771	TonB-dependent receptor
HUI95_08965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUI95_08970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUI95_08975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUI95_08990	COG1570	exodeoxyribonuclease VII activity
HUI95_09015	COG3158	transport of potassium into the cell
HUI95_09020	COG0517	IMP dehydrogenase activity
HUI95_09020	COG0516	GMP reductase activity
HUI95_09025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUI95_09025	COG0519	Catalyzes the synthesis of GMP from XMP
HUI95_09075	COG2062	phosphohistidine phosphatase, SixA
HUI95_09085	COG0697	spore germination
HUI95_09090	COG4166	transmembrane transport
HUI95_09095	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUI95_09100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUI95_09110	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUI95_09115	COG1136	(ABC) transporter
HUI95_09120	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUI95_09135	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUI95_09140	COG0740	serine-type endopeptidase activity
HUI95_09145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUI95_09150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUI95_09155	COG0776	regulation of translation
HUI95_09160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUI95_09165	COG0488	(ABC) transporter
HUI95_09170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUI95_09175	COG3162	membrane
HUI95_09190	COG1024	Enoyl-CoA hydratase
HUI95_09195	COG1115	amino acid carrier protein
HUI95_09210	COG1584	GPR1 FUN34 yaaH family protein
HUI95_09245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUI95_09250	COG1960	acyl-CoA dehydrogenase activity
HUI95_09260	COG1960	acyl-CoA dehydrogenase activity
HUI95_09265	COG1024	Enoyl-CoA hydratase
HUI95_09270	COG1024	Enoyl-CoA hydratase
HUI95_09280	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_09290	COG0730	response to heat
HUI95_09335	COG3423	Transcriptional regulator
HUI95_09370	COG1073	alpha beta
HUI95_09375	COG0823	Involved in the tonB-independent uptake of proteins
HUI95_09375	COG1506	peptidase
HUI95_09380	COG0702	epimerase
HUI95_09385	COG0583	DNA-binding transcription factor activity
HUI95_09390	COG0667	Aldo Keto reductase
HUI95_09440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUI95_09445	COG1215	transferase activity, transferring glycosyl groups
HUI95_09450	COG0438	transferase activity, transferring glycosyl groups
HUI95_09520	COG0438	transferase activity, transferring glycosyl groups
HUI95_09525	COG0583	DNA-binding transcription factor activity
HUI95_09530	COG2723	6-phospho-beta-galactosidase activity
HUI95_09535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUI95_09545	COG0583	DNA-binding transcription factor activity
HUI95_09550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUI95_09555	COG0673	inositol 2-dehydrogenase activity
HUI95_09560	COG0583	DNA-binding transcription factor activity
HUI95_09570	COG1560	Kdo2-lipid A biosynthetic process
HUI95_09575	COG1560	Kdo2-lipid A biosynthetic process
HUI95_09590	COG5001	Diguanylate cyclase
HUI95_09590	COG3300	MHYT domain
HUI95_09600	COG0417	DNA replication proofreading
HUI95_09630	COG0534	Mate efflux family protein
HUI95_09640	COG0307	riboflavin synthase, alpha
HUI95_09650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUI95_09655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUI95_09660	COG0697	spore germination
HUI95_09665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUI95_09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUI95_09710	COG3099	Belongs to the UPF0263 family
HUI95_09715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUI95_09720	COG2894	cell division
HUI95_09725	COG0850	regulation of cytokinetic process
HUI95_09730	COG3100	YcgL domain-containing protein
HUI95_09735	COG2951	lytic endotransglycosylase activity
HUI95_09740	COG1760	l-serine dehydratase
HUI95_09745	COG1760	l-serine dehydratase
HUI95_09750	COG3123	guanosine phosphorylase activity
HUI95_09770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUI95_09775	COG2067	long-chain fatty acid transport protein
HUI95_09790	COG1595	DNA-templated transcription, initiation
HUI95_09820	COG0714	Associated with various cellular activities
HUI95_09825	COG0183	Belongs to the thiolase family
HUI95_09830	COG1024	Enoyl-CoA hydratase
HUI95_09830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUI95_09850	COG3829	transcription factor binding
HUI95_09855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUI95_09860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUI95_09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUI95_09875	COG0549	Belongs to the carbamate kinase family
HUI95_09880	COG0697	spore germination
HUI95_09885	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUI95_09885	COG3608	succinylglutamate desuccinylase aspartoacylase
HUI95_09890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUI95_09895	COG2068	MobA-Related Protein
HUI95_09900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_09900	COG0493	'glutamate synthase
HUI95_09905	COG0402	S-adenosylhomocysteine deaminase activity
HUI95_09910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUI95_09915	COG2080	2 iron, 2 sulfur cluster binding
HUI95_09915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUI95_09920	COG2233	PERMEase
HUI95_09925	COG0402	S-adenosylhomocysteine deaminase activity
HUI95_09930	COG2252	PERMEase
HUI95_09935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUI95_09940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUI95_09945	COG2080	2 iron, 2 sulfur cluster binding
HUI95_09955	COG3134	Outer membrane lipoprotein
HUI95_09970	COG1288	antiporter activity
HUI95_09975	COG0318	PFAM AMP-dependent synthetase and ligase
HUI95_09980	COG2378	regulation of single-species biofilm formation
HUI95_09990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUI95_09990	COG0140	phosphoribosyl-ATP diphosphatase activity
HUI95_09995	COG0107	imidazoleglycerol-phosphate synthase activity
HUI95_10000	COG2205	protein histidine kinase activity
HUI95_10000	COG0784	Response regulator, receiver
HUI95_10000	COG2198	Histidine kinase
HUI95_10005	COG2199	diguanylate cyclase activity
HUI95_10010	COG3437	response regulator, receiver
HUI95_10015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUI95_10020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUI95_10025	COG0131	Imidazoleglycerol-phosphate dehydratase
HUI95_10025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUI95_10030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUI95_10035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUI95_10040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUI95_10050	COG1199	ATP-dependent helicase activity
HUI95_10055	COG1214	PFAM Peptidase M22, glycoprotease
HUI95_10070	COG0318	PFAM AMP-dependent synthetase and ligase
HUI95_10075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUI95_10090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUI95_10095	COG2832	Protein of unknown function (DUF454)
HUI95_10100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUI95_10110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUI95_10115	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUI95_10125	COG3314	Sporulation integral membrane protein YlbJ
HUI95_10135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUI95_10135	COG0617	tRNA 3'-terminal CCA addition
HUI95_10135	COG0517	IMP dehydrogenase activity
HUI95_10140	COG1643	Atp-dependent helicase
HUI95_10150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUI95_10160	COG3437	response regulator, receiver
HUI95_10165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUI95_10170	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUI95_10175	COG0709	Synthesizes selenophosphate from selenide and ATP
HUI95_10190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUI95_10195	COG0840	transmembrane signaling receptor activity
HUI95_10200	COG1254	Belongs to the acylphosphatase family
HUI95_10205	COG0625	glutathione transferase activity
HUI95_10210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUI95_10210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUI95_10215	COG0489	protein tyrosine kinase activity
HUI95_10220	COG0572	uridine kinase
HUI95_10225	COG0717	Belongs to the dCTP deaminase family
HUI95_10230	COG0306	phosphate transporter
HUI95_10235	COG1530	ribonuclease E activity
HUI95_10245	COG0546	phosphoglycolate phosphatase activity
HUI95_10250	COG0424	maF-like protein
HUI95_10260	COG1399	metal-binding, possibly nucleic acid-binding protein
HUI95_10265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUI95_10270	COG0416	fatty acid biosynthetic process
HUI95_10275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUI95_10285	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_10290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUI95_10300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUI95_10305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUI95_10310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUI95_10315	COG0470	DNA polymerase III
HUI95_10320	COG0084	hydrolase, TatD family'
HUI95_10385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUI95_10385	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HUI95_10390	COG3008	intermembrane lipid transfer
HUI95_10395	COG2995	paraquat-inducible protein a
HUI95_10405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUI95_10410	COG0372	Belongs to the citrate synthase family
HUI95_10455	COG4221	oxidoreductase activity
HUI95_10465	COG3141	response to X-ray
HUI95_10490	COG4128	Pfam Zonular occludens toxin
HUI95_10575	COG4128	Pfam Zonular occludens toxin
HUI95_10580	COG1598	PFAM Uncharacterised protein family UPF0150
HUI95_10635	COG4128	Pfam Zonular occludens toxin
HUI95_10640	COG1598	PFAM Uncharacterised protein family UPF0150
HUI95_10650	COG1067	ATP-dependent peptidase activity
HUI95_10655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUI95_10670	COG0488	(ABC) transporter
HUI95_10680	COG0116	Belongs to the methyltransferase superfamily
HUI95_10680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUI95_10695	COG0167	dihydroorotate dehydrogenase activity
HUI95_10700	COG2902	Dehydrogenase
HUI95_10710	COG0308	aminopeptidase N
HUI95_10720	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HUI95_10725	COG1956	GAF domain-containing protein
HUI95_10735	COG3278	Belongs to the heme-copper respiratory oxidase family
HUI95_10750	COG2010	Cytochrome c
HUI95_10775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUI95_10780	COG0589	response to stress
HUI95_10785	COG0037	tRNA processing
HUI95_10800	COG0625	glutathione transferase activity
HUI95_10805	COG1869	D-ribose catabolic process
HUI95_10810	COG1129	ABC transporter
HUI95_10815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUI95_10820	COG1879	ABC-type sugar transport system periplasmic component
HUI95_10825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUI95_10830	COG1609	Transcriptional regulator
HUI95_10835	COG5001	Diguanylate cyclase
HUI95_10835	COG3300	MHYT domain
HUI95_10860	COG2205	protein histidine kinase activity
HUI95_10860	COG0784	Response regulator, receiver
HUI95_10865	COG0776	regulation of translation
HUI95_10870	COG0072	phenylalanine-tRNA ligase activity
HUI95_10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUI95_10875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUI95_10880	COG4974	Belongs to the 'phage' integrase family
HUI95_10895	COG3620	sequence-specific DNA binding
HUI95_10950	COG4916	TIR domain
HUI95_10955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUI95_10975	COG4695	Portal protein
HUI95_11105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUI95_11110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUI95_11115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUI95_11120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUI95_11145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUI95_11155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUI95_11165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUI95_11170	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUI95_11175	COG3313	Fe-S protein
HUI95_11180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_11180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_11180	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HUI95_11185	COG1105	Belongs to the carbohydrate kinase PfkB family
HUI95_11190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_11190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_11195	COG1609	Transcriptional regulator
HUI95_11200	COG0814	amino acid
HUI95_11215	COG0513	Belongs to the DEAD box helicase family
HUI95_11225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUI95_11230	COG2890	protein-(glutamine-N5) methyltransferase activity
HUI95_11235	COG2840	Smr protein MutS2
HUI95_11245	COG3706	GGDEF domain
HUI95_11275	COG2824	Alkylphosphonate utilization operon protein PhnA
HUI95_11290	COG0384	phenazine biosynthesis protein PhzF
HUI95_11315	COG0242	peptide deformylase activity
HUI95_11340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUI95_11345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HUI95_11350	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HUI95_11360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUI95_11365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUI95_11375	COG0205	6-phosphofructokinase activity
HUI95_11380	COG1473	amidohydrolase
HUI95_11385	COG1011	Hydrolase
HUI95_11390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUI95_11445	COG3593	DNA synthesis involved in DNA repair
HUI95_11465	COG0730	response to heat
HUI95_11470	COG3148	PFAM DTW domain containing protein
HUI95_11480	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUI95_11490	COG0386	Belongs to the glutathione peroxidase family
HUI95_11495	COG0513	Belongs to the DEAD box helicase family
HUI95_11500	COG0456	acetyltransferase
HUI95_11535	COG2329	Antibiotic biosynthesis monooxygenase
HUI95_11540	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUI95_11570	COG2501	S4 domain
HUI95_11585	COG1132	(ABC) transporter
HUI95_11590	COG1132	(ABC) transporter
HUI95_11600	COG3118	belongs to the thioredoxin family
HUI95_11605	COG0471	metal ion transport
HUI95_11610	COG0058	SHG alpha-glucan phosphorylase activity
HUI95_11640	COG0814	amino acid
HUI95_11645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HUI95_11650	COG0514	ATP-dependent DNA helicase (RecQ)
HUI95_11655	COG2766	serine protein kinase
HUI95_11660	COG2718	Belongs to the UPF0229 family
HUI95_11665	COG2719	SpoVR family
HUI95_11670	COG2186	Transcriptional regulator
HUI95_11675	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUI95_11680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUI95_11685	COG0586	Pfam SNARE associated Golgi protein
HUI95_11695	COG0556	nucleotide-excision repair
HUI95_11705	COG2985	domain, Protein
HUI95_11705	COG0569	domain protein
HUI95_11710	COG0739	heme binding
HUI95_11710	COG0741	lytic transglycosylase activity
HUI95_11710	COG1196	nuclear chromosome segregation
HUI95_11715	COG3181	Tripartite tricarboxylate transporter family receptor
HUI95_11730	COG4565	transcriptional regulatory protein
HUI95_11735	COG3290	protein histidine kinase activity
HUI95_11740	COG1940	carbohydrate kinase activity
HUI95_11740	COG1846	Transcriptional regulator
HUI95_11745	COG0840	transmembrane signaling receptor activity
HUI95_11750	COG3012	SEC-C Motif Domain Protein
HUI95_11755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUI95_11760	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HUI95_11765	COG0247	lactate metabolic process
HUI95_11780	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HUI95_11785	COG0437	4 iron, 4 sulfur cluster binding
HUI95_11790	COG3301	Polysulphide reductase, NrfD
HUI95_11795	COG1138	Cytochrome C-type biogenesis protein
HUI95_11800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUI95_11805	COG3088	subunit of a heme lyase
HUI95_11805	COG4235	cytochrome complex assembly
HUI95_11820	COG3033	Beta-eliminating lyase
HUI95_11830	COG3046	protein related to deoxyribodipyrimidine photolyase
HUI95_11835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUI95_11855	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUI95_11870	COG4774	siderophore transport
HUI95_11875	COG4977	sequence-specific DNA binding
HUI95_11885	COG0583	DNA-binding transcription factor activity
HUI95_11890	COG2910	NAD(P)H-binding
HUI95_11900	COG0626	cystathionine gamma-synthase activity
HUI95_11905	COG0612	Peptidase, M16
HUI95_11910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUI95_11920	COG1944	ATP diphosphatase activity
HUI95_11925	COG2116	formate transmembrane transporter activity
HUI95_11930	COG1882	Formate acetyltransferase
HUI95_11935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUI95_11945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUI95_11955	COG1840	ABC-type Fe3 transport system, periplasmic component
HUI95_11960	COG3842	ATPase activity
HUI95_11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUI95_11975	COG2983	Belongs to the UPF0260 family
HUI95_11985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUI95_11990	COG0045	succinate-CoA ligase (ADP-forming) activity
HUI95_11995	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUI95_12000	COG0567	Dehydrogenase, E1 component
HUI95_12015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUI95_12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUI95_12045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HUI95_12045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUI95_12055	COG3069	C4-dicarboxylate transmembrane transporter activity
HUI95_12070	COG1451	nucleotide metabolic process
HUI95_12085	COG0254	rRNA binding
HUI95_12090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUI95_12100	COG0583	DNA-binding transcription factor activity
HUI95_12105	COG2925	Exonuclease
HUI95_12115	COG3345	alpha-galactosidase
HUI95_12120	COG1380	Effector of murein hydrolase LrgA
HUI95_12125	COG1346	cytolysis
HUI95_12130	COG0295	cytidine deaminase activity
HUI95_12135	COG1022	Amp-dependent synthetase and ligase
HUI95_12150	COG0861	Integral membrane protein TerC family
HUI95_12155	COG2885	chlorophyll binding
HUI95_12180	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUI95_12190	COG3768	UPF0283 membrane protein
HUI95_12195	COG3106	COG3106 Predicted ATPase
HUI95_12210	COG1842	Phage shock protein A
HUI95_12215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HUI95_12225	COG4168	peptide transport system, permease
HUI95_12230	COG4171	peptide transport system, permease
HUI95_12240	COG4172	Belongs to the ABC transporter superfamily
HUI95_12250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUI95_12255	COG1286	toxin biosynthetic process
HUI95_12260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUI95_12265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUI95_12270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUI95_12275	COG1674	ftsk spoiiie
HUI95_12275	COG0531	amino acid
HUI95_12285	COG0492	ferredoxin-NADP+ reductase activity
HUI95_12290	COG3706	GGDEF domain
HUI95_12295	COG3134	Outer membrane lipoprotein
HUI95_12300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUI95_12305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HUI95_12310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUI95_12315	COG0542	response to heat
HUI95_12320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUI95_12325	COG1278	Cold shock
HUI95_12330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUI95_12390	COG3829	transcription factor binding
HUI95_12465	COG3501	Rhs element vgr protein
HUI95_12490	COG1435	thymidine kinase activity
HUI95_12495	COG1757	Na H antiporter
HUI95_12500	COG2916	Histone family protein nucleoid-structuring protein H-NS
HUI95_12505	COG2096	Adenosyltransferase
HUI95_12510	COG3530	Putative quorum-sensing-regulated virulence factor
HUI95_12515	COG0602	queuosine metabolic process
HUI95_12520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUI95_12540	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HUI95_12550	COG0776	regulation of translation
HUI95_12555	COG0539	negative regulation of cytoplasmic translation
HUI95_12560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUI95_12565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUI95_12575	COG0583	DNA-binding transcription factor activity
HUI95_12595	COG0778	Nitroreductase
HUI95_12600	COG5001	Diguanylate cyclase
HUI95_12600	COG3300	MHYT domain
HUI95_12610	COG0583	DNA-binding transcription factor activity
HUI95_12615	COG3437	response regulator, receiver
HUI95_12640	COG4989	oxidoreductase activity
HUI95_12645	COG0724	RNA recognition motif
HUI95_12665	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUI95_12685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUI95_12690	COG1360	Flagellar Motor Protein
HUI95_12695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_12700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_12705	COG0649	NAD binding
HUI95_12705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_12720	COG1034	ATP synthesis coupled electron transport
HUI95_12725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUI95_12730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_12735	COG0839	Belongs to the complex I subunit 6 family
HUI95_12740	COG0713	ATP synthesis coupled electron transport
HUI95_12750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUI95_12755	COG1007	ATP synthesis coupled electron transport
HUI95_12765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUI95_12770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUI95_12770	COG2199	diguanylate cyclase activity
HUI95_12775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUI95_12775	COG0047	phosphoribosylformylglycinamidine synthase activity
HUI95_12780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUI95_12785	COG1645	bacterial-type flagellum-dependent swarming motility
HUI95_12790	COG1160	GTP binding
HUI95_12795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUI95_12800	COG2976	Protein conserved in bacteria
HUI95_12805	COG0124	histidyl-tRNA synthetase
HUI95_12810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUI95_12825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUI95_12830	COG0105	UTP biosynthetic process
HUI95_12835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUI95_12845	COG0633	Ferredoxin
HUI95_12850	COG0443	Heat shock 70 kDa protein
HUI95_12855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUI95_12865	COG0822	iron-sulfur transferase activity
HUI95_12870	COG1104	cysteine desulfurase activity
HUI95_12890	COG3154	lipid carrier protein
HUI95_12895	COG0826	peptidase U32
HUI95_12900	COG0826	peptidase U32
HUI95_12915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUI95_12920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUI95_12925	COG1862	Preprotein translocase
HUI95_12930	COG0343	queuine tRNA-ribosyltransferase activity
HUI95_12935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUI95_12940	COG0517	IMP dehydrogenase activity
HUI95_12950	COG3634	alkyl hydroperoxide reductase activity
HUI95_12955	COG0477	Major facilitator Superfamily
HUI95_12960	COG3852	Histidine kinase
HUI95_12975	COG3119	arylsulfatase activity
HUI95_12980	COG0641	radical SAM
HUI95_12985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUI95_12985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUI95_12990	COG0509	glycine decarboxylation via glycine cleavage system
HUI95_12995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUI95_13000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUI95_13005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUI95_13025	COG2814	Major facilitator Superfamily
HUI95_13030	COG0625	glutathione transferase activity
HUI95_13040	COG0483	inositol monophosphate 1-phosphatase activity
HUI95_13060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUI95_13070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUI95_13100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUI95_13120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUI95_13120	COG0301	tRNA thio-modification
HUI95_13130	COG4953	penicillin-binding protein 1C
HUI95_13135	COG2373	Large extracellular alpha-helical protein
HUI95_13140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUI95_13150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUI95_13190	COG1215	transferase activity, transferring glycosyl groups
HUI95_13190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUI95_13195	COG0438	transferase activity, transferring glycosyl groups
HUI95_13205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUI95_13210	COG1216	Glycosyl transferase, family 2
HUI95_13235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_13245	COG2431	L-lysine efflux transmembrane transporter activity
HUI95_13250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUI95_13270	COG1393	Belongs to the ArsC family
HUI95_13280	COG4783	chaperone-mediated protein folding
HUI95_13285	COG0425	Belongs to the sulfur carrier protein TusA family
HUI95_13310	COG3842	ATPase activity
HUI95_13315	COG3833	ABC-type maltose transport systems, permease component
HUI95_13320	COG1175	transmembrane transport
HUI95_13330	COG3081	Nucleoid-associated protein
HUI95_13335	COG3082	Protein of unknown function (DUF1414)
HUI95_13340	COG3083	sulfuric ester hydrolase activity
HUI95_13345	COG4771	TonB-dependent receptor
HUI95_13350	COG1770	oligopeptidase
HUI95_13370	COG4574	serine-type endopeptidase inhibitor activity
HUI95_13375	COG3085	chromosome segregation
HUI95_13380	COG0583	DNA-binding transcription factor activity
HUI95_13385	COG0287	Prephenate dehydrogenase
HUI95_13385	COG1605	Chorismate mutase
HUI95_13390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUI95_13395	COG0584	glycerophosphoryl diester phosphodiesterase
HUI95_13410	COG1349	DNA-binding transcription factor activity
HUI95_13415	COG2271	Major facilitator Superfamily
HUI95_13420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUI95_13425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUI95_13430	COG0840	transmembrane signaling receptor activity
HUI95_13440	COG0583	DNA-binding transcription factor activity
HUI95_13465	COG0656	L-ascorbic acid biosynthetic process
HUI95_13470	COG2814	Major facilitator Superfamily
HUI95_13485	COG3220	belongs to the UPF0276 family
HUI95_13505	COG1294	oxidase, subunit
HUI95_13515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUI95_13525	COG2979	Protein of unknown function (DUF533)
HUI95_13560	COG0583	DNA-binding transcription factor activity
HUI95_13570	COG2807	transmembrane transport
HUI95_13580	COG1187	pseudouridine synthase activity
HUI95_13600	COG2801	Transposase and inactivated derivatives
HUI95_13620	COG1403	HNH endonuclease
HUI95_13635	COG3681	Belongs to the UPF0597 family
HUI95_13645	COG0814	amino acid
HUI95_13665	COG0583	DNA-binding transcription factor activity
HUI95_13670	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HUI95_13680	COG1166	arginine decarboxylase activity
HUI95_13690	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUI95_13720	COG0583	DNA-binding transcription factor activity
HUI95_13730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUI95_13735	COG0840	transmembrane signaling receptor activity
HUI95_13740	COG0302	gtp cyclohydrolase
HUI95_13750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUI95_13755	COG2267	carboxylic ester hydrolase activity
HUI95_13760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUI95_13775	COG0314	molybdopterin synthase activity
HUI95_13780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUI95_13785	COG0315	cyclic pyranopterin monophosphate synthase activity
HUI95_13790	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUI95_13795	COG3005	denitrification pathway
HUI95_13805	COG0348	domain, Protein
HUI95_13810	COG0437	4 iron, 4 sulfur cluster binding
HUI95_13815	COG0243	molybdopterin cofactor binding
HUI95_13825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_13825	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_13830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUI95_13835	COG3850	Histidine kinase
HUI95_13840	COG2197	response regulator
HUI95_13850	COG2205	protein histidine kinase activity
HUI95_13850	COG0784	Response regulator, receiver
HUI95_13870	COG0121	glutamine amidotransferase
HUI95_13875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUI95_13880	COG1960	acyl-CoA dehydrogenase activity
HUI95_13885	COG3437	response regulator, receiver
HUI95_13885	COG0784	Response regulator, receiver
HUI95_13895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUI95_13900	COG0328	RNA-DNA hybrid ribonuclease activity
HUI95_13905	COG2226	methyltransferase
HUI95_13910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUI95_13915	COG0741	lytic transglycosylase activity
HUI95_13915	COG1388	LysM domain
HUI95_13920	COG3021	interspecies interaction between organisms
HUI95_13930	COG1607	acyl-coa hydrolase
HUI95_13945	COG0741	lytic transglycosylase activity
HUI95_13955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUI95_13975	COG2911	Protein conserved in bacteria
HUI95_13980	COG0729	surface antigen
HUI95_13990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUI95_13995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUI95_14005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUI95_14015	COG4134	Bacterial extracellular solute-binding protein
HUI95_14025	COG4136	ATPase activity
HUI95_14030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUI95_14035	COG2951	lytic endotransglycosylase activity
HUI95_14050	COG1846	Transcriptional regulator
HUI95_14060	COG0033	Phosphoglucomutase
HUI95_14065	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HUI95_14070	COG0596	Alpha beta hydrolase
HUI95_14085	COG0716	FMN binding
HUI95_14095	COG0735	belongs to the Fur family
HUI95_14100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUI95_14110	COG2190	(PTS) system
HUI95_14110	COG1263	PTS System
HUI95_14110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUI95_14115	COG0363	glucosamine-6-phosphate deaminase activity
HUI95_14120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUI95_14125	COG1940	carbohydrate kinase activity
HUI95_14125	COG1846	Transcriptional regulator
HUI95_14130	COG2194	sulfuric ester hydrolase activity
HUI95_14135	COG0217	transcriptional regulatory protein
HUI95_14140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUI95_14145	COG1801	Protein of unknown function DUF72
HUI95_14150	COG4106	trans-aconitate 2-methyltransferase activity
HUI95_14155	COG0500	methyltransferase
HUI95_14175	COG0450	alkyl hydroperoxide reductase
HUI95_14180	COG0583	DNA-binding transcription factor activity
HUI95_14190	COG0791	NLP P60 protein
HUI95_14205	COG1309	transcriptional regulator
HUI95_14245	COG0534	Mate efflux family protein
HUI95_14255	COG2841	Protein conserved in bacteria
HUI95_14265	COG2366	antibiotic biosynthetic process
HUI95_14270	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUI95_14270	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUI95_14270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUI95_14270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HUI95_14280	COG0633	Ferredoxin
HUI95_14280	COG3217	Mosc domain protein beta barrel domain protein
HUI95_14280	COG0633	Ferredoxin
HUI95_14280	COG3217	Mosc domain protein beta barrel domain protein
HUI95_14290	COG0501	Belongs to the peptidase M48B family
HUI95_14295	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUI95_14305	COG0156	8-amino-7-oxononanoate synthase activity
HUI95_14310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUI95_14330	COG0017	Asparaginyl-tRNA synthetase
HUI95_14335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HUI95_14350	COG3069	C4-dicarboxylate transmembrane transporter activity
HUI95_14360	COG0583	DNA-binding transcription factor activity
HUI95_14365	COG1393	Belongs to the ArsC family
HUI95_14370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUI95_14375	COG1876	peptidase activity
HUI95_14385	COG3263	regulation of cellular component size
HUI95_14405	COG1280	lysine exporter protein (LysE YggA)
HUI95_14435	COG0564	pseudouridine synthase activity
HUI95_14445	COG1454	alcohol dehydrogenase
HUI95_14450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUI95_14455	COG0702	epimerase
HUI95_14460	COG2914	Belongs to the UPF0125 (RnfH) family
HUI95_14465	COG2867	negative regulation of translational initiation
HUI95_14470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUI95_14500	COG0583	DNA-binding transcription factor activity
HUI95_14505	COG3048	D-serine ammonia-lyase activity
HUI95_14515	COG0659	secondary active sulfate transmembrane transporter activity
HUI95_14520	COG0538	isocitrate dehydrogenase activity
HUI95_14525	COG2207	Transcriptional regulator
HUI95_14545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_14555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUI95_14560	COG1263	PTS System
HUI95_14560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUI95_14565	COG1609	Transcriptional regulator
HUI95_14575	COG0456	acetyltransferase
HUI95_14585	COG2801	Transposase and inactivated derivatives
HUI95_14595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_14595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_14595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_14605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_14605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_14605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUI95_14615	COG1187	pseudouridine synthase activity
HUI95_14625	COG0482	sulfurtransferase activity
HUI95_14630	COG2915	High frequency lysogenization protein hflD homolog
HUI95_14635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUI95_14640	COG2850	peptidyl-arginine hydroxylation
HUI95_14655	COG3153	acetyltransferase
HUI95_14665	COG0625	glutathione transferase activity
HUI95_14670	COG0259	pyridoxamine-phosphate oxidase activity
HUI95_14685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUI95_14685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUI95_14690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUI95_14710	COG4235	cytochrome complex assembly
HUI95_14710	COG3088	subunit of a heme lyase
HUI95_14715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUI95_14720	COG1138	Cytochrome C-type biogenesis protein
HUI95_14725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HUI95_14730	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUI95_14735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUI95_14740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUI95_14755	COG0835	chemotaxis
HUI95_14765	COG1192	Involved in chromosome partitioning
HUI95_14775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUI95_14780	COG2201	protein-glutamate methylesterase activity
HUI95_14785	COG0643	Histidine kinase
HUI95_14785	COG2198	Histidine kinase
HUI95_14785	COG0784	Response regulator, receiver
HUI95_14790	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HUI95_14815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUI95_14825	COG1684	flagellar biosynthetic protein fliR
HUI95_14880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUI95_14890	COG1677	Flagellar hook-basal body complex protein FliE
HUI95_14905	COG1393	Belongs to the ArsC family
HUI95_14910	COG0798	PFAM Bile acid sodium symporter
HUI95_14925	COG0640	Transcriptional regulator
HUI95_14930	COG1342	Belongs to the UPF0251 family
HUI95_14945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUI95_14950	COG1073	alpha beta
HUI95_14950	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HUI95_14950	COG3064	Membrane
HUI95_14955	COG2994	toxin metabolic process
HUI95_14965	COG2274	protein secretion by the type I secretion system
HUI95_14975	COG2274	protein secretion by the type I secretion system
HUI95_14995	COG1737	Transcriptional regulator
HUI95_15000	COG0469	pyruvate kinase activity
HUI95_15015	COG1960	acyl-CoA dehydrogenase activity
HUI95_15025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUI95_15035	COG0243	molybdopterin cofactor binding
HUI95_15040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUI95_15045	COG0583	DNA-binding transcription factor activity
HUI95_15080	COG1454	alcohol dehydrogenase
HUI95_15080	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_15090	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_15090	COG1454	alcohol dehydrogenase
HUI95_15095	COG1882	Formate acetyltransferase
HUI95_15100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUI95_15110	COG4869	propanediol catabolic process
HUI95_15135	COG1376	ErfK ybiS ycfS ynhG family protein
HUI95_15135	COG1388	LysM domain
HUI95_15150	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HUI95_15155	COG0791	NLP P60 protein
HUI95_15165	COG3118	belongs to the thioredoxin family
HUI95_15175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUI95_15180	COG0788	formyltetrahydrofolate deformylase activity
HUI95_15190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUI95_15210	COG0366	Alpha amylase catalytic
HUI95_15215	COG0741	lytic transglycosylase activity
HUI95_15215	COG0739	heme binding
HUI95_15215	COG1196	nuclear chromosome segregation
HUI95_15220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUI95_15225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUI95_15230	COG0673	inositol 2-dehydrogenase activity
HUI95_15255	COG3152	Membrane
HUI95_15275	COG1104	cysteine desulfurase activity
HUI95_15290	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_15295	COG1280	lysine exporter protein (LysE YggA)
HUI95_15305	COG1032	radical SAM domain protein
HUI95_15315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUI95_15320	COG1566	PFAM secretion protein HlyD family protein
HUI95_15330	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUI95_15335	COG0733	neurotransmitter:sodium symporter activity
HUI95_15365	COG0281	malic enzyme
HUI95_15370	COG2207	Transcriptional regulator
HUI95_15375	COG0534	Mate efflux family protein
HUI95_15390	COG2233	PERMEase
HUI95_15395	COG0095	Lipoate-protein ligase
HUI95_15400	COG1115	amino acid carrier protein
HUI95_15405	COG0019	diaminopimelate decarboxylase activity
HUI95_15425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUI95_15435	COG1126	abc transporter atp-binding protein
HUI95_15440	COG0765	amino acid transport
HUI95_15445	COG4597	amino acid ABC transporter
HUI95_15450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_15465	COG1131	(ABC) transporter
HUI95_15470	COG0545	Peptidyl-prolyl cis-trans isomerase
HUI95_15485	COG3142	Participates in the control of copper homeostasis
HUI95_15510	COG5002	protein histidine kinase activity
HUI95_15515	COG0745	RESPONSE REGULATOR receiver
HUI95_15520	COG0346	lactoylglutathione lyase activity
HUI95_15525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUI95_15530	COG1960	acyl-CoA dehydrogenase activity
HUI95_15535	COG3284	Transcriptional regulator
HUI95_15550	COG0697	spore germination
HUI95_15555	COG4565	transcriptional regulatory protein
HUI95_15560	COG3290	protein histidine kinase activity
HUI95_15565	COG0281	malic enzyme
HUI95_15580	COG1846	Transcriptional regulator
HUI95_15585	COG1566	PFAM secretion protein HlyD family protein
HUI95_15615	COG0602	queuosine metabolic process
HUI95_15620	COG1328	CTP reductase activity
HUI95_15630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUI95_15635	COG3115	cell septum assembly
HUI95_15640	COG1196	nuclear chromosome segregation
HUI95_15650	COG2860	membrane
HUI95_15660	COG3108	Peptidase M15
HUI95_15665	COG2989	Protein conserved in bacteria
HUI95_15680	COG0463	Glycosyl transferase, family 2
HUI95_15695	COG0366	Alpha amylase catalytic
HUI95_15730	COG3706	GGDEF domain
HUI95_15740	COG3590	peptidase
HUI95_15750	COG0488	(ABC) transporter
HUI95_15760	COG0531	amino acid
HUI95_15765	COG0814	amino acid
HUI95_15780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUI95_15785	COG1982	Orn Lys Arg decarboxylase major
HUI95_15790	COG0531	amino acid
HUI95_15795	COG3710	Transcriptional regulator
HUI95_15800	COG0825	malonyl-CoA metabolic process
HUI95_15810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUI95_15815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUI95_15820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUI95_15825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUI95_15830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUI95_15845	COG0750	zinc metalloprotease
HUI95_15850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUI95_15855	COG0575	Belongs to the CDS family
HUI95_15860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUI95_15865	COG0233	cytoplasmic translational termination
HUI95_15870	COG0528	UMP kinase activity
HUI95_15875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUI95_15880	COG0052	Belongs to the universal ribosomal protein uS2 family
HUI95_15885	COG0024	Methionine aminopeptidase
HUI95_15890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUI95_15895	COG2171	N-acyltransferase activity
HUI95_15925	COG0564	pseudouridine synthase activity
HUI95_15930	COG3098	single-species biofilm formation
HUI95_15955	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HUI95_15965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUI95_15965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUI95_15980	COG1611	Belongs to the LOG family
HUI95_15985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUI95_15990	COG0473	3-isopropylmalate dehydrogenase activity
HUI95_16000	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HUI95_16005	COG2363	Small membrane protein
HUI95_16015	COG0583	DNA-binding transcription factor activity
HUI95_16020	COG0840	transmembrane signaling receptor activity
HUI95_16025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUI95_16040	COG1477	protein flavinylation
HUI95_16045	COG2871	sodium ion transport
HUI95_16050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUI95_16055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUI95_16060	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUI95_16065	COG1805	sodium ion transport
HUI95_16070	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUI95_16075	COG0271	Belongs to the BolA IbaG family
HUI95_16080	COG2813	Specifically methylates the guanine in position
HUI95_16090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUI95_16100	COG2211	Major facilitator Superfamily
HUI95_16105	COG3248	Nucleoside-binding outer membrane protein
HUI95_16110	COG1666	GTP binding
HUI95_16115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUI95_16120	COG0693	protein deglycase activity
HUI95_16155	COG2801	Transposase and inactivated derivatives
HUI95_16200	COG2771	luxR family
HUI95_16210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUI95_16210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUI95_16215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUI95_16225	COG1151	hydroxylamine reductase activity
HUI95_16230	COG0783	Belongs to the Dps family
HUI95_16255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUI95_16270	COG4221	oxidoreductase activity
HUI95_16280	COG0415	Belongs to the DNA photolyase family
HUI95_16285	COG0789	Transcriptional regulator
HUI95_16290	COG3272	Protein of unknown function (DUF1722)
HUI95_16320	COG1605	Chorismate mutase
HUI95_16320	COG0077	Prephenate dehydratase
HUI95_16345	COG1349	DNA-binding transcription factor activity
HUI95_16350	COG2084	Dehydrogenase
HUI95_16360	COG0235	Class ii aldolase
HUI95_16365	COG3622	Belongs to the hyi family
HUI95_16370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUI95_16375	COG2610	gluconate transmembrane transporter activity
HUI95_16385	COG0840	transmembrane signaling receptor activity
HUI95_16395	COG0300	oxidoreductase activity
HUI95_16420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUI95_16450	COG0826	peptidase U32
HUI95_16455	COG1280	lysine exporter protein (LysE YggA)
HUI95_16465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUI95_16475	COG0745	RESPONSE REGULATOR receiver
HUI95_16485	COG0643	Histidine kinase
HUI95_16485	COG2198	Histidine kinase
HUI95_16495	COG0835	chemotaxis
HUI95_16500	COG0840	transmembrane signaling receptor activity
HUI95_16510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUI95_16515	COG2201	protein-glutamate methylesterase activity
HUI95_16520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUI95_16545	COG2199	diguanylate cyclase activity
HUI95_16545	COG2200	EAL domain
HUI95_16545	COG2203	Gaf domain
HUI95_16550	COG0826	peptidase U32
HUI95_16555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUI95_16560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUI95_16575	COG2200	EAL domain
HUI95_16580	COG0737	Belongs to the 5'-nucleotidase family
HUI95_16600	COG2204	response regulator
HUI95_16605	COG0545	Peptidyl-prolyl cis-trans isomerase
HUI95_16615	COG2900	Belongs to the SlyX family
HUI95_16620	COG1047	Peptidyl-prolyl cis-trans
HUI95_16625	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HUI95_16635	COG0835	chemotaxis
HUI95_16635	COG0784	Response regulator, receiver
HUI95_16640	COG0429	hydrolase of the alpha beta-hydrolase fold
HUI95_16645	COG3089	Belongs to the UPF0270 family
HUI95_16655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUI95_16660	COG0463	Glycosyl transferase, family 2
HUI95_16665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUI95_16665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUI95_16670	COG0726	polysaccharide deacetylase
HUI95_16675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUI95_16680	COG2076	Multidrug Resistance protein
HUI95_16685	COG2076	Multidrug Resistance protein
HUI95_16690	COG3954	Phosphoribulokinase
HUI95_16705	COG1765	OsmC-like protein
HUI95_16720	COG3397	chitin binding
HUI95_16735	COG2202	Pas domain
HUI95_16735	COG2205	protein histidine kinase activity
HUI95_16745	COG3655	Transcriptional regulator
HUI95_16755	COG2814	Major facilitator Superfamily
HUI95_16760	COG4771	TonB-dependent receptor
HUI95_16780	COG0748	coenzyme F420 binding
HUI95_16785	COG3721	Heme iron utilization protein
HUI95_16795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUI95_16800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUI95_16825	COG0741	lytic transglycosylase activity
HUI95_16830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUI95_16845	COG0488	(ABC) transporter
HUI95_16855	COG2252	PERMEase
HUI95_16860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUI95_16865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUI95_16870	COG3178	'Phosphotransferase
HUI95_16875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUI95_16885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUI95_16890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUI95_16895	COG2967	ApaG domain
HUI95_16900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUI95_16910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUI95_16915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUI95_16930	COG0318	PFAM AMP-dependent synthetase and ligase
HUI95_16935	COG3314	Sporulation integral membrane protein YlbJ
HUI95_16940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUI95_16945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUI95_16950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUI95_16955	COG0142	geranyltranstransferase activity
HUI95_16960	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HUI95_16965	COG0330	HflC and HflK could
HUI95_16970	COG0330	HflC and HflK could
HUI95_16975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUI95_16980	COG1923	regulation of RNA biosynthetic process
HUI95_16985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUI95_16990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUI95_17000	COG0802	atpase or kinase
HUI95_17005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUI95_17005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUI95_17025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUI95_17030	COG2011	ABC-type metal ion transport system permease component
HUI95_17035	COG1464	Belongs to the NlpA lipoprotein family
HUI95_17045	COG0840	transmembrane signaling receptor activity
HUI95_17070	COG5002	protein histidine kinase activity
HUI95_17070	COG0784	Response regulator, receiver
HUI95_17070	COG2198	Histidine kinase
HUI95_17090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HUI95_17105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUI95_17110	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HUI95_17120	COG2716	regulation of RNA biosynthetic process
HUI95_17125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUI95_17130	COG3013	Belongs to the UPF0304 family
HUI95_17140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUI95_17145	COG0280	phosphate acetyltransferase
HUI95_17145	COG0857	belongs to the CobB CobQ family
HUI95_17150	COG0440	acetolactate synthase activity
HUI95_17155	COG0028	Belongs to the TPP enzyme family
HUI95_17170	COG0671	phosphoesterase, PA-phosphatase related
HUI95_17180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUI95_17185	COG0473	3-isopropylmalate dehydrogenase activity
HUI95_17190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUI95_17195	COG0066	3-isopropylmalate dehydratase activity
HUI95_17210	COG4143	(ABC) transporter
HUI95_17220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HUI95_17230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUI95_17240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUI95_17270	COG0316	Belongs to the HesB IscA family
HUI95_17280	COG0038	chloride channel
HUI95_17285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUI95_17300	COG0671	phosphoesterase, PA-phosphatase related
HUI95_17310	COG3437	response regulator, receiver
HUI95_17310	COG0784	Response regulator, receiver
HUI95_17320	COG2076	Multidrug Resistance protein
HUI95_17330	COG0346	lactoylglutathione lyase activity
HUI95_17335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUI95_17340	COG1643	Atp-dependent helicase
HUI95_17350	COG1489	DNA binding
HUI95_17355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUI95_17360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUI95_17365	COG0617	tRNA 3'-terminal CCA addition
HUI95_17375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUI95_17380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUI95_17400	COG1924	4 iron, 4 sulfur cluster binding
HUI95_17405	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HUI95_17410	COG0842	Transport permease protein
HUI95_17415	COG1131	(ABC) transporter
HUI95_17430	COG0163	prenyltransferase activity
HUI95_17435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUI95_17440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUI95_17455	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HUI95_17470	COG1136	(ABC) transporter
HUI95_17505	COG2801	Transposase and inactivated derivatives
HUI95_17510	COG0529	Catalyzes the synthesis of activated sulfate
HUI95_17515	COG0471	metal ion transport
HUI95_17515	COG3273	potassium ion transport
HUI95_17520	COG2895	sulfate adenylyltransferase (ATP) activity
HUI95_17525	COG0175	sulfate reduction
HUI95_17530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUI95_17530	COG1648	precorrin-2 dehydrogenase activity
HUI95_17535	COG0330	HflC and HflK could
HUI95_17540	COG1585	Membrane protein implicated in regulation of membrane protease activity
HUI95_17545	COG0517	IMP dehydrogenase activity
HUI95_17545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUI95_17550	COG0488	(ABC) transporter
HUI95_17560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUI95_17565	COG0583	DNA-binding transcription factor activity
HUI95_17595	COG0789	Transcriptional regulator
HUI95_17605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUI95_17615	COG0668	transmembrane transport
HUI95_17625	COG2731	YhcH YjgK YiaL family protein
HUI95_17640	COG1794	racemase activity, acting on amino acids and derivatives
HUI95_17655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUI95_17680	COG0733	neurotransmitter:sodium symporter activity
HUI95_17690	COG0733	neurotransmitter:sodium symporter activity
HUI95_17705	COG0561	phosphatase activity
HUI95_17735	COG1846	Transcriptional regulator
HUI95_17740	COG2130	NADP-dependent
HUI95_17745	COG1051	belongs to the nudix hydrolase family
HUI95_17765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUI95_17770	COG1640	4-alpha-glucanotransferase
HUI95_17775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUI95_17780	COG0676	glucose-6-phosphate 1-epimerase activity
HUI95_17785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUI95_17790	COG0840	transmembrane signaling receptor activity
HUI95_17865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HUI95_17870	COG2885	chlorophyll binding
HUI95_17875	COG0823	Involved in the tonB-independent uptake of proteins
HUI95_17890	COG0811	peptide transport
HUI95_17895	COG0824	Thioesterase
HUI95_17900	COG3790	cyd operon protein YbgE
HUI95_17905	COG4890	Cyd operon protein YbgT
HUI95_17910	COG1294	oxidase, subunit
HUI95_17915	COG1271	oxidase subunit
HUI95_17920	COG2255	four-way junction helicase activity
HUI95_17925	COG0632	four-way junction helicase activity
HUI95_17930	COG0840	transmembrane signaling receptor activity
HUI95_17935	COG0442	prolyl-tRNA aminoacylation
HUI95_17940	COG4221	oxidoreductase activity
HUI95_17955	COG1024	Enoyl-CoA hydratase
HUI95_17965	COG0110	maltose O-acetyltransferase activity
HUI95_17975	COG4166	transmembrane transport
HUI95_17990	COG1872	DUF167
HUI95_17995	COG0762	integral membrane protein
HUI95_18000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUI95_18005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUI95_18020	COG3022	response to hydroperoxide
HUI95_18025	COG0513	Belongs to the DEAD box helicase family
HUI95_18030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUI95_18055	COG0735	belongs to the Fur family
HUI95_18060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUI95_18075	COG0776	regulation of translation
HUI95_18110	COG0560	Phosphoserine phosphatase
HUI95_18120	COG3447	MASE1 domain protein
HUI95_18120	COG5001	Diguanylate cyclase
HUI95_18120	COG5002	protein histidine kinase activity
HUI95_18125	COG0813	purine-nucleoside phosphorylase activity
HUI95_18130	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HUI95_18135	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUI95_18140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUI95_18150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUI95_18155	COG0084	hydrolase, TatD family'
HUI95_18160	COG2165	general secretion pathway protein
HUI95_18175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUI95_18180	COG0004	ammonium transporteR
HUI95_18185	COG4974	Belongs to the 'phage' integrase family
HUI95_18275	COG4695	Portal protein
HUI95_18325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUI95_18400	COG4974	Belongs to the 'phage' integrase family
HUI95_18490	COG4695	Portal protein
HUI95_18540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUI95_18625	COG0795	lipopolysaccharide-transporting ATPase activity
HUI95_18630	COG0795	lipopolysaccharide-transporting ATPase activity
HUI95_18635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUI95_18640	COG2927	DNA polymerase III (CHI subunit)
HUI95_18645	COG0525	valine-tRNA ligase activity
HUI95_18650	COG1253	flavin adenine dinucleotide binding
HUI95_18655	COG0586	Pfam SNARE associated Golgi protein
HUI95_18660	COG1686	Belongs to the peptidase S11 family
HUI95_18695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HUI95_18700	COG0527	aspartate kinase activity
HUI95_18705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUI95_18715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUI95_18720	COG1546	Belongs to the CinA family
HUI95_18725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUI95_18745	COG3068	Protein conserved in bacteria
HUI95_18755	COG0739	heme binding
HUI95_18775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HUI95_18780	COG1121	(ABC) transporter
HUI95_18785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUI95_18790	COG0583	DNA-binding transcription factor activity
HUI95_18795	COG0697	spore germination
HUI95_18800	COG1573	uracil-dna glycosylase
HUI95_18805	COG2962	Rard protein
HUI95_18815	COG2827	Endonuclease containing a URI domain
HUI95_18830	COG1842	Phage shock protein A
HUI95_18835	COG0204	Acyl-transferase
HUI95_18855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUI95_18915	COG0583	DNA-binding transcription factor activity
HUI95_18925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUI95_18935	COG0583	DNA-binding transcription factor activity
HUI95_18955	COG1289	transmembrane transporter activity
HUI95_18960	COG1566	PFAM secretion protein HlyD family protein
HUI95_18975	COG1051	belongs to the nudix hydrolase family
HUI95_18980	COG3150	esterase
HUI95_18990	COG3151	Protein conserved in bacteria
HUI95_18995	COG0494	nUDIX hydrolase
HUI95_19000	COG1538	Outer membrane efflux protein
HUI95_19005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUI95_19005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUI95_19010	COG1560	Kdo2-lipid A biosynthetic process
HUI95_19025	COG1392	Phosphate transport regulator
HUI95_19030	COG0306	phosphate transporter
HUI95_19035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUI95_19065	COG0583	DNA-binding transcription factor activity
HUI95_19070	COG1380	Effector of murein hydrolase LrgA
HUI95_19075	COG1346	cytolysis
HUI95_19090	COG0617	tRNA 3'-terminal CCA addition
HUI95_19095	COG3267	Type II secretory pathway component ExeA
HUI95_19095	COG3409	Peptidoglycan-binding domain 1 protein
HUI95_19105	COG1194	a g-specific adenine glycosylase
HUI95_19110	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HUI95_19120	COG3111	PFAM Bacterial OB fold (BOF) protein
HUI95_19125	COG3240	lipase activity
HUI95_19140	COG3009	Protein conserved in bacteria
HUI95_19145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUI95_19145	COG3008	intermembrane lipid transfer
HUI95_19150	COG2995	paraquat-inducible protein a
HUI95_19160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUI95_19170	COG5001	Diguanylate cyclase
HUI95_19170	COG2203	Gaf domain
HUI95_19170	COG3706	GGDEF domain
HUI95_19170	COG4251	negative regulation of phosphorylation
HUI95_19175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUI95_19180	COG2813	Specifically methylates the guanine in position
HUI95_19185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUI95_19190	COG0297	glycogen (starch) synthase activity
HUI95_19230	COG1757	Na H antiporter
HUI95_19235	COG0583	DNA-binding transcription factor activity
HUI95_19240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUI95_19245	COG3842	ATPase activity
HUI95_19250	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUI95_19255	COG1177	transmembrane transport
HUI95_19260	COG1012	belongs to the aldehyde dehydrogenase family
HUI95_19285	COG0110	maltose O-acetyltransferase activity
HUI95_19290	COG0366	Alpha amylase catalytic
HUI95_19300	COG1609	Transcriptional regulator
HUI95_19315	COG0252	asparaginase activity
HUI95_19330	COG1803	Methylglyoxal synthase
HUI95_19355	COG1444	tRNA N-acetyltransferase activity
HUI95_19365	COG0835	chemotaxis
HUI95_19365	COG0784	Response regulator, receiver
HUI95_19370	COG3314	Sporulation integral membrane protein YlbJ
HUI95_19385	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HUI95_19400	COG2801	Transposase and inactivated derivatives
HUI95_19465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUI95_19470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUI95_19485	COG0477	Major facilitator Superfamily
HUI95_19490	COG0523	cobalamin synthesis protein
HUI95_19500	COG1280	lysine exporter protein (LysE YggA)
HUI95_19510	COG2200	EAL domain
HUI95_19515	COG1049	propionate catabolic process, 2-methylcitrate cycle
HUI95_19520	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUI95_19525	COG0840	transmembrane signaling receptor activity
HUI95_19530	COG0840	transmembrane signaling receptor activity
HUI95_19540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUI95_19545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUI95_19550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUI95_19555	COG2186	Transcriptional regulator
HUI95_19580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUI95_19585	COG1459	type II secretion system
HUI95_19600	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HUI95_19605	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUI95_19610	COG0494	nUDIX hydrolase
HUI95_19620	COG0653	protein targeting
HUI95_19630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUI95_19635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUI95_19640	COG0849	cell division
HUI95_19645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUI95_19650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUI95_19655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUI95_19660	COG0772	Belongs to the SEDS family
HUI95_19665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUI95_19670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUI95_19675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUI95_19685	COG0768	penicillin binding
HUI95_19690	COG3116	cell division
HUI95_19695	COG0275	rRNA processing
HUI95_19700	COG2001	Belongs to the MraZ family
HUI95_19710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUI95_19715	COG3107	peptidoglycan biosynthetic process
HUI95_19720	COG0792	nuclease activity
HUI95_19725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUI95_19730	COG2823	Periplasmic or secreted lipoprotein
HUI95_19735	COG2969	positive regulation of protein catabolic process
HUI95_19740	COG0625	glutathione transferase activity
HUI95_19745	COG2857	Cytochrome c1
HUI95_19750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUI95_19755	COG0723	plastoquinol--plastocyanin reductase activity
HUI95_19760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUI95_19765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUI95_19770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUI95_19780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUI95_19785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUI95_19815	COG3964	amidohydrolase
HUI95_19830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_19830	COG3711	transcriptional antiterminator
HUI95_19835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_19840	COG1660	Displays ATPase and GTPase activities
HUI95_19845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUI95_19855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUI95_19860	COG1137	ATPase activity
HUI95_19865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HUI95_19870	COG3117	lipopolysaccharide transmembrane transporter activity
HUI95_19875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUI95_19880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUI95_19880	COG0517	IMP dehydrogenase activity
HUI95_19885	COG1127	ABC transporter
HUI95_19890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUI95_19895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUI95_19900	COG2854	intermembrane phospholipid transfer
HUI95_19910	COG5007	Belongs to the BolA IbaG family
HUI95_19915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUI95_19920	COG0312	modulator of DNA gyrase
HUI95_19925	COG3028	Belongs to the UPF0307 family
HUI95_19935	COG2926	Belongs to the UPF0265 family
HUI95_19965	COG1396	sequence-specific DNA binding
HUI95_19970	COG3135	benzoate transporter
HUI95_19995	COG0840	transmembrane signaling receptor activity
HUI95_20000	COG3047	cAMP biosynthetic process
HUI95_20010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUI95_20015	COG2197	response regulator
HUI95_20025	COG4974	Belongs to the 'phage' integrase family
HUI95_20050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUI95_20070	COG3436	PFAM IS66 Orf2 family protein
HUI95_20130	COG3539	Fimbrial protein
HUI95_20135	COG3121	Chaperone
HUI95_20140	COG3188	usher protein
HUI95_20145	COG3539	Fimbrial protein
HUI95_20180	COG2916	Histone family protein nucleoid-structuring protein H-NS
HUI95_20195	COG5642	Protein of unknown function (DUF2384)
HUI95_20265	COG2181	nitrate reductase activity
HUI95_20270	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUI95_20280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HUI95_20285	COG2223	nitrite transmembrane transporter activity
HUI95_20290	COG3850	Histidine kinase
HUI95_20295	COG2197	response regulator
HUI95_20305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUI95_20350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUI95_20380	COG1396	sequence-specific DNA binding
HUI95_20410	COG4771	TonB-dependent receptor
HUI95_20415	COG4251	negative regulation of phosphorylation
HUI95_20415	COG3706	GGDEF domain
HUI95_20415	COG2203	Gaf domain
HUI95_20415	COG5001	Diguanylate cyclase
HUI95_20460	COG0346	lactoylglutathione lyase activity
HUI95_20470	COG0583	DNA-binding transcription factor activity
HUI95_20480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUI95_20485	COG1074	ATP-dependent DNA helicase activity
HUI95_20490	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HUI95_20495	COG2259	Doxx family
HUI95_20500	COG1741	Belongs to the pirin family
HUI95_20510	COG0583	DNA-binding transcription factor activity
HUI95_20535	COG1175	transmembrane transport
HUI95_20545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUI95_20555	COG3706	GGDEF domain
HUI95_20575	COG1247	-acetyltransferase
HUI95_20605	COG0628	permease
HUI95_20610	COG4221	oxidoreductase activity
HUI95_20615	COG2957	Belongs to the agmatine deiminase family
HUI95_20620	COG0583	DNA-binding transcription factor activity
HUI95_20625	COG3284	Transcriptional regulator
HUI95_20640	COG1461	Dihydroxyacetone kinase
HUI95_20645	COG2376	Dihydroxyacetone kinase
HUI95_20650	COG2252	PERMEase
HUI95_20690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUI95_20695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUI95_20700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUI95_20705	COG0049	tRNA binding
HUI95_20710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUI95_20715	COG2168	tRNA wobble position uridine thiolation
HUI95_20730	COG0251	oxidation-reduction process
HUI95_20735	COG2964	Protein conserved in bacteria
HUI95_20740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUI95_20745	COG0085	RNA polymerase activity
HUI95_20750	COG0222	ribosome binding
HUI95_20755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUI95_20760	COG0081	regulation of translation
HUI95_20765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUI95_20770	COG0250	Participates in transcription elongation, termination and antitermination
HUI95_20785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUI95_20810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUI95_20815	COG0569	domain protein
HUI95_20820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUI95_20840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUI95_20845	COG3005	denitrification pathway
HUI95_20850	COG0243	molybdopterin cofactor binding
HUI95_20880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HUI95_20895	COG2204	response regulator
HUI95_20905	COG2205	protein histidine kinase activity
HUI95_20920	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_20925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUI95_20925	COG3620	sequence-specific DNA binding
HUI95_20925	COG0617	tRNA 3'-terminal CCA addition
HUI95_20930	COG5413	integral membrane protein
HUI95_20940	COG1522	sequence-specific DNA binding
HUI95_20945	COG2502	aspartate--ammonia ligase
HUI95_20950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUI95_20955	COG0542	response to heat
HUI95_20965	COG0564	pseudouridine synthase activity
HUI95_20970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUI95_20975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUI95_20985	COG3681	Belongs to the UPF0597 family
HUI95_20995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HUI95_21000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUI95_21005	COG1979	alcohol dehydrogenase
HUI95_21010	COG2207	Transcriptional regulator
HUI95_21015	COG3040	lipid binding
HUI95_21030	COG0688	phosphatidylethanolamine metabolic process
HUI95_21050	COG0540	Belongs to the ATCase OTCase family
HUI95_21055	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HUI95_21060	COG1438	arginine binding
HUI95_21065	COG1288	antiporter activity
HUI95_21070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUI95_21120	COG3250	beta-galactosidase activity
HUI95_21125	COG1609	Transcriptional regulator
HUI95_21130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUI95_21140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUI95_21145	COG2017	converts alpha-aldose to the beta-anomer
HUI95_21150	COG0667	Aldo Keto reductase
HUI95_21155	COG1968	undecaprenyl-diphosphatase activity
HUI95_21160	COG3806	Anti-sigma factor
HUI95_21165	COG1595	DNA-templated transcription, initiation
HUI95_21185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUI95_21190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUI95_21195	COG0477	Major facilitator Superfamily
HUI95_21205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUI95_21215	COG2116	formate transmembrane transporter activity
HUI95_21220	COG1648	precorrin-2 dehydrogenase activity
HUI95_21220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUI95_21225	COG2239	Acts as a magnesium transporter
HUI95_21235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUI95_21240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUI95_21250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUI95_21260	COG0514	ATP-dependent DNA helicase (RecQ)
HUI95_21265	COG2050	protein possibly involved in aromatic compounds catabolism
HUI95_21280	COG2258	MOSC domain
HUI95_21285	COG1177	transmembrane transport
HUI95_21290	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUI95_21295	COG3842	ATPase activity
HUI95_21315	COG0174	glutamine synthetase
HUI95_21335	COG3045	CreA protein
HUI95_21340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUI95_21345	COG0443	Heat shock 70 kDa protein
HUI95_21350	COG3187	Heat shock protein
HUI95_21360	COG0366	Alpha amylase catalytic
HUI95_21365	COG1086	Polysaccharide biosynthesis protein
HUI95_21370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUI95_21380	COG1083	cytidylyl-transferase
HUI95_21385	COG2089	acid synthase
HUI95_21400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUI95_21410	COG1216	Glycosyl transferase, family 2
HUI95_21420	COG1216	Glycosyl transferase, family 2
HUI95_21430	COG0463	Glycosyl transferase, family 2
HUI95_21445	COG0318	PFAM AMP-dependent synthetase and ligase
HUI95_21450	COG1028	Short-chain dehydrogenase reductase Sdr
HUI95_21465	COG1083	cytidylyl-transferase
HUI95_21475	COG2089	acid synthase
HUI95_21495	COG4310	Domain of unknown function (DUF2172)
HUI95_21530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUI95_21535	COG0745	RESPONSE REGULATOR receiver
HUI95_21540	COG2205	protein histidine kinase activity
HUI95_21550	COG0281	malic enzyme
HUI95_21555	COG0702	epimerase
HUI95_21560	COG0254	rRNA binding
HUI95_21565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUI95_21595	COG0129	dihydroxy-acid dehydratase activity
HUI95_21605	COG3978	acetolactate synthase activity
HUI95_21615	COG0606	chelatase, subunit chli
HUI95_21620	COG0204	Acyl-transferase
HUI95_21625	COG0204	Acyl-transferase
HUI95_21630	COG1683	Conserved Protein
HUI95_21640	COG1335	isochorismatase
HUI95_21650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HUI95_21655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUI95_21660	COG3639	organic phosphonate transmembrane transporter activity
HUI95_21665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUI95_21670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUI95_21680	COG3084	Protein conserved in bacteria
HUI95_21685	COG3706	GGDEF domain
HUI95_21685	COG4251	negative regulation of phosphorylation
HUI95_21685	COG5001	Diguanylate cyclase
HUI95_21685	COG2203	Gaf domain
HUI95_21690	COG0789	Transcriptional regulator
HUI95_21700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUI95_21705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUI95_21710	COG1561	YicC-like family, N-terminal region
HUI95_21725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUI95_21735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUI95_21745	COG1132	(ABC) transporter
HUI95_21745	COG2375	cellular response to nickel ion
HUI95_21750	COG1132	(ABC) transporter
HUI95_21755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUI95_21760	COG4605	iron ion homeostasis
HUI95_21765	COG4604	ABC transporter, ATP-binding protein
HUI95_21770	COG4607	ABC-type enterochelin transport system periplasmic component
HUI95_21775	COG4774	siderophore transport
HUI95_21795	COG3306	glycosyltransferase involved in LPS biosynthesis
HUI95_21810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUI95_21825	COG1063	alcohol dehydrogenase
HUI95_21830	COG3245	cytochrome
HUI95_21835	COG3300	MHYT domain
HUI95_21835	COG5001	Diguanylate cyclase
HUI95_21845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUI95_21850	COG2166	iron-sulfur cluster assembly
HUI95_21855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUI95_21885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUI95_21890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUI95_21890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUI95_21895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HUI95_21900	COG3074	FtsZ-dependent cytokinesis
HUI95_21910	COG1045	serine acetyltransferase
HUI95_21920	COG0745	RESPONSE REGULATOR receiver
HUI95_21925	COG2205	protein histidine kinase activity
HUI95_21930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUI95_21935	COG0534	Mate efflux family protein
HUI95_21950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUI95_21955	COG2937	Belongs to the GPAT DAPAT family
HUI95_21960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUI95_21965	COG3161	chorismate lyase activity
HUI95_21970	COG1580	Controls the rotational direction of flagella during chemotaxis
HUI95_21985	COG0604	alcohol dehydrogenase
HUI95_21990	COG1609	Transcriptional regulator
HUI95_22010	COG1519	Transferase
HUI95_22015	COG0859	PFAM glycosyl transferase family 9
HUI95_22020	COG0463	Glycosyl transferase, family 2
HUI95_22025	COG0859	PFAM glycosyl transferase family 9
HUI95_22030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUI95_22035	COG2990	Protein conserved in bacteria
HUI95_22040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUI95_22050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUI95_22055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUI95_22060	COG2003	Belongs to the UPF0758 family
HUI95_22065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUI95_22070	COG0756	dUTP diphosphatase activity
HUI95_22075	COG1309	transcriptional regulator
HUI95_22080	COG0668	transmembrane transport
HUI95_22090	COG0166	Belongs to the GPI family
HUI95_22095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUI95_22100	COG0583	DNA-binding transcription factor activity
HUI95_22115	COG0045	succinate-CoA ligase (ADP-forming) activity
HUI95_22115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUI95_22115	COG1042	CoA-binding domain protein
HUI95_22145	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HUI95_22150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUI95_22155	COG1739	Uncharacterized protein family UPF0029
HUI95_22160	COG0006	proline dipeptidase activity
HUI95_22165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUI95_22170	COG1024	Enoyl-CoA hydratase
HUI95_22170	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUI95_22175	COG0183	Belongs to the thiolase family
HUI95_22200	COG0425	Belongs to the sulfur carrier protein TusA family
HUI95_22205	COG0251	oxidation-reduction process
HUI95_22215	COG2885	chlorophyll binding
HUI95_22225	COG2818	Glycosylase
HUI95_22230	COG0752	glycyl-tRNA synthetase alpha subunit
HUI95_22235	COG0751	glycine-tRNA ligase activity
HUI95_22270	COG0814	amino acid
HUI95_22275	COG0348	domain, Protein
HUI95_22285	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUI95_22290	COG0426	domain, Protein
HUI95_22290	COG1773	rubredoxin
HUI95_22295	COG3604	Transcriptional regulator
HUI95_22300	COG2188	Transcriptional regulator
HUI95_22315	COG1609	Transcriptional regulator
HUI95_22355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUI95_22380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUI95_22395	COG3118	belongs to the thioredoxin family
HUI95_22400	COG0513	Belongs to the DEAD box helicase family
HUI95_22405	COG0248	Ppx GppA phosphatase
HUI95_22420	COG0742	ribosomal rna small subunit methyltransferase
HUI95_22425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUI95_22445	COG0084	hydrolase, TatD family'
HUI95_22450	COG0805	protein transport
HUI95_22455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUI95_22465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUI95_22470	COG3165	ubiquinone biosynthetic process from chorismate
HUI95_22475	COG2226	methyltransferase
HUI95_22480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUI95_22485	COG0402	S-adenosylhomocysteine deaminase activity
HUI95_22525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HUI95_22530	COG0848	biopolymer transport protein
HUI95_22535	COG0811	peptide transport
HUI95_22540	COG0811	peptide transport
HUI95_22550	COG2771	luxR family
HUI95_22555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUI95_22560	COG1349	DNA-binding transcription factor activity
HUI95_22565	COG0745	RESPONSE REGULATOR receiver
HUI95_22570	COG2205	protein histidine kinase activity
HUI95_22580	COG4452	Inner membrane protein CreD
HUI95_22585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUI95_22590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUI95_22595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUI95_22600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUI95_22605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUI95_22610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUI95_22615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUI95_22625	COG0356	it plays a direct role in the translocation of protons across the membrane
HUI95_22635	COG1475	DNA binding
HUI95_22640	COG1192	Involved in chromosome partitioning
HUI95_22645	COG0357	Ribosomal RNA small subunit methyltransferase G
HUI95_22650	COG0445	tRNA wobble uridine modification
HUI95_22655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUI95_22660	COG4774	siderophore transport
HUI95_22665	COG4615	Cyclic peptide transporter
HUI95_22670	COG1120	ATPase activity
HUI95_22680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUI95_22685	COG3550	peptidyl-serine autophosphorylation
HUI95_22695	COG2801	Transposase and inactivated derivatives
HUI95_22705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUI95_22710	COG0706	membrane insertase activity
HUI95_22715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUI95_22720	COG0594	ribonuclease P activity
HUI95_22725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUI95_22730	COG1126	abc transporter atp-binding protein