locus-tag	class	description
LEO81_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEO81_00010	COG0592	DNA-directed DNA polymerase activity
LEO81_00030	COG2378	regulation of single-species biofilm formation
LEO81_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO81_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO81_00045	COG3977	Valine--pyruvate aminotransferase
LEO81_00060	COG2814	Major facilitator Superfamily
LEO81_00065	COG0745	RESPONSE REGULATOR receiver
LEO81_00070	COG2205	protein histidine kinase activity
LEO81_00090	COG3539	Fimbrial protein
LEO81_00095	COG3188	usher protein
LEO81_00100	COG3121	Chaperone
LEO81_00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO81_00125	COG4191	Histidine kinase
LEO81_00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_00130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO81_00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_00140	COG1309	transcriptional regulator
LEO81_00175	COG2271	Major facilitator Superfamily
LEO81_00195	COG0561	phosphatase activity
LEO81_00200	COG2267	carboxylic ester hydrolase activity
LEO81_00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO81_00215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO81_00220	COG1758	RNA polymerase activity
LEO81_00230	COG0859	PFAM glycosyl transferase family 9
LEO81_00235	COG3642	lipopolysaccharide core region biosynthetic process
LEO81_00275	COG0589	response to stress
LEO81_00280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO81_00290	COG1528	Iron-storage protein
LEO81_00295	COG2081	HI0933 family
LEO81_00300	COG2223	nitrite transmembrane transporter activity
LEO81_00310	COG3275	phosphorelay sensor kinase activity
LEO81_00315	COG3279	Response regulator of the LytR AlgR family
LEO81_00320	COG2223	nitrite transmembrane transporter activity
LEO81_00325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEO81_00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEO81_00345	COG0583	DNA-binding transcription factor activity
LEO81_00355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEO81_00390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEO81_00395	COG2166	iron-sulfur cluster assembly
LEO81_00400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO81_00410	COG3300	MHYT domain
LEO81_00410	COG5001	Diguanylate cyclase
LEO81_00415	COG3245	cytochrome
LEO81_00420	COG1063	alcohol dehydrogenase
LEO81_00435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO81_00450	COG3306	glycosyltransferase involved in LPS biosynthesis
LEO81_00470	COG4774	siderophore transport
LEO81_00475	COG4607	ABC-type enterochelin transport system periplasmic component
LEO81_00480	COG4604	ABC transporter, ATP-binding protein
LEO81_00485	COG4605	iron ion homeostasis
LEO81_00490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO81_00495	COG1132	(ABC) transporter
LEO81_00500	COG1132	(ABC) transporter
LEO81_00500	COG2375	cellular response to nickel ion
LEO81_00510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO81_00520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO81_00535	COG1561	YicC-like family, N-terminal region
LEO81_00540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEO81_00545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEO81_00555	COG0789	Transcriptional regulator
LEO81_00560	COG2203	Gaf domain
LEO81_00560	COG3706	GGDEF domain
LEO81_00560	COG4251	negative regulation of phosphorylation
LEO81_00560	COG5001	Diguanylate cyclase
LEO81_00565	COG3084	Protein conserved in bacteria
LEO81_00575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEO81_00580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO81_00585	COG3639	organic phosphonate transmembrane transporter activity
LEO81_00590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LEO81_00595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LEO81_00605	COG1335	isochorismatase
LEO81_00615	COG1683	Conserved Protein
LEO81_00620	COG0204	Acyl-transferase
LEO81_00625	COG0204	Acyl-transferase
LEO81_00630	COG0606	chelatase, subunit chli
LEO81_00640	COG3978	acetolactate synthase activity
LEO81_00650	COG0129	dihydroxy-acid dehydratase activity
LEO81_00680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEO81_00685	COG0254	rRNA binding
LEO81_00690	COG0702	epimerase
LEO81_00695	COG0281	malic enzyme
LEO81_00705	COG2205	protein histidine kinase activity
LEO81_00710	COG0745	RESPONSE REGULATOR receiver
LEO81_00715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO81_00750	COG4310	Domain of unknown function (DUF2172)
LEO81_00770	COG2089	acid synthase
LEO81_00780	COG1083	cytidylyl-transferase
LEO81_00795	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_00800	COG0318	PFAM AMP-dependent synthetase and ligase
LEO81_00815	COG1215	transferase activity, transferring glycosyl groups
LEO81_00820	COG1442	glycosyl transferase family 8
LEO81_00860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO81_00870	COG4106	trans-aconitate 2-methyltransferase activity
LEO81_00885	COG0529	Catalyzes the synthesis of activated sulfate
LEO81_00895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO81_00900	COG3848	Pyruvate phosphate dikinase
LEO81_00900	COG0574	Belongs to the PEP-utilizing enzyme family
LEO81_00905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO81_00910	COG1213	nucleotidyl transferase
LEO81_00915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO81_00920	COG1086	Polysaccharide biosynthesis protein
LEO81_00925	COG0366	Alpha amylase catalytic
LEO81_00935	COG3187	Heat shock protein
LEO81_00940	COG0443	Heat shock 70 kDa protein
LEO81_00945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO81_00950	COG3045	CreA protein
LEO81_00970	COG0174	glutamine synthetase
LEO81_00990	COG3842	ATPase activity
LEO81_00995	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO81_01000	COG1177	transmembrane transport
LEO81_01005	COG2258	MOSC domain
LEO81_01020	COG2050	protein possibly involved in aromatic compounds catabolism
LEO81_01025	COG0514	ATP-dependent DNA helicase (RecQ)
LEO81_01035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEO81_01045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEO81_01050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO81_01060	COG2239	Acts as a magnesium transporter
LEO81_01065	COG1648	precorrin-2 dehydrogenase activity
LEO81_01065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO81_01070	COG2116	formate transmembrane transporter activity
LEO81_01080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO81_01090	COG0477	Major facilitator Superfamily
LEO81_01095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LEO81_01100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LEO81_01110	COG0018	arginyl-trna synthetase
LEO81_01120	COG1595	DNA-templated transcription, initiation
LEO81_01125	COG3806	Anti-sigma factor
LEO81_01130	COG1968	undecaprenyl-diphosphatase activity
LEO81_01135	COG0667	Aldo Keto reductase
LEO81_01140	COG2017	converts alpha-aldose to the beta-anomer
LEO81_01145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO81_01155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO81_01160	COG1609	Transcriptional regulator
LEO81_01165	COG3250	beta-galactosidase activity
LEO81_01215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO81_01220	COG1288	antiporter activity
LEO81_01225	COG1438	arginine binding
LEO81_01230	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEO81_01235	COG0540	Belongs to the ATCase OTCase family
LEO81_01255	COG0688	phosphatidylethanolamine metabolic process
LEO81_01275	COG2207	Transcriptional regulator
LEO81_01280	COG1979	alcohol dehydrogenase
LEO81_01285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEO81_01290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEO81_01300	COG3681	Belongs to the UPF0597 family
LEO81_01310	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO81_01315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO81_01320	COG0564	pseudouridine synthase activity
LEO81_01330	COG0542	response to heat
LEO81_01335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO81_01340	COG2502	aspartate--ammonia ligase
LEO81_01345	COG1522	sequence-specific DNA binding
LEO81_01355	COG5413	integral membrane protein
LEO81_01360	COG0517	IMP dehydrogenase activity
LEO81_01360	COG0516	GMP reductase activity
LEO81_01365	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_01380	COG2205	protein histidine kinase activity
LEO81_01390	COG2204	response regulator
LEO81_01405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LEO81_01435	COG0243	molybdopterin cofactor binding
LEO81_01440	COG3005	denitrification pathway
LEO81_01445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEO81_01465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO81_01470	COG0569	domain protein
LEO81_01475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEO81_01500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO81_01515	COG0250	Participates in transcription elongation, termination and antitermination
LEO81_01520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEO81_01525	COG0081	regulation of translation
LEO81_01530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEO81_01535	COG0222	ribosome binding
LEO81_01540	COG0085	RNA polymerase activity
LEO81_01545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEO81_01550	COG2964	Protein conserved in bacteria
LEO81_01555	COG0251	oxidation-reduction process
LEO81_01570	COG2168	tRNA wobble position uridine thiolation
LEO81_01575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEO81_01580	COG0049	tRNA binding
LEO81_01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEO81_01590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO81_01595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO81_01630	COG2252	PERMEase
LEO81_01635	COG2376	Dihydroxyacetone kinase
LEO81_01640	COG1461	Dihydroxyacetone kinase
LEO81_01655	COG3284	Transcriptional regulator
LEO81_01660	COG4221	oxidoreductase activity
LEO81_01665	COG0628	permease
LEO81_01670	COG0671	phosphoesterase, PA-phosphatase related
LEO81_01695	COG1247	-acetyltransferase
LEO81_01715	COG3706	GGDEF domain
LEO81_01725	COG3842	ATPase activity
LEO81_01735	COG1175	transmembrane transport
LEO81_01760	COG0583	DNA-binding transcription factor activity
LEO81_01770	COG1741	Belongs to the pirin family
LEO81_01775	COG2259	Doxx family
LEO81_01780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LEO81_01785	COG1074	ATP-dependent DNA helicase activity
LEO81_01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO81_01800	COG0583	DNA-binding transcription factor activity
LEO81_01810	COG0346	lactoylglutathione lyase activity
LEO81_01855	COG4251	negative regulation of phosphorylation
LEO81_01855	COG2203	Gaf domain
LEO81_01855	COG3706	GGDEF domain
LEO81_01855	COG5001	Diguanylate cyclase
LEO81_01860	COG4771	TonB-dependent receptor
LEO81_01890	COG2197	response regulator
LEO81_01895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEO81_01905	COG3047	cAMP biosynthetic process
LEO81_01910	COG0840	transmembrane signaling receptor activity
LEO81_01935	COG3135	benzoate transporter
LEO81_01940	COG1396	sequence-specific DNA binding
LEO81_01970	COG2926	Belongs to the UPF0265 family
LEO81_01980	COG3028	Belongs to the UPF0307 family
LEO81_01985	COG0312	modulator of DNA gyrase
LEO81_01990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEO81_01995	COG5007	Belongs to the BolA IbaG family
LEO81_02005	COG2854	intermembrane phospholipid transfer
LEO81_02010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO81_02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEO81_02020	COG1127	ABC transporter
LEO81_02025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO81_02025	COG0517	IMP dehydrogenase activity
LEO81_02030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEO81_02040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LEO81_02045	COG1137	ATPase activity
LEO81_02050	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LEO81_02060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_02065	COG1660	Displays ATPase and GTPase activities
LEO81_02070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_02075	COG3711	transcriptional antiterminator
LEO81_02075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_02090	COG3964	amidohydrolase
LEO81_02120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO81_02125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO81_02135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LEO81_02140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEO81_02145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEO81_02150	COG0723	plastoquinol--plastocyanin reductase activity
LEO81_02155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEO81_02160	COG2857	Cytochrome c1
LEO81_02165	COG0625	glutathione transferase activity
LEO81_02170	COG2969	positive regulation of protein catabolic process
LEO81_02175	COG2823	Periplasmic or secreted lipoprotein
LEO81_02180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO81_02185	COG0792	nuclease activity
LEO81_02190	COG3107	peptidoglycan biosynthetic process
LEO81_02195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEO81_02205	COG2001	Belongs to the MraZ family
LEO81_02210	COG0275	rRNA processing
LEO81_02215	COG3116	cell division
LEO81_02220	COG0768	penicillin binding
LEO81_02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEO81_02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO81_02240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEO81_02245	COG0772	Belongs to the SEDS family
LEO81_02250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO81_02255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO81_02260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LEO81_02265	COG0849	cell division
LEO81_02270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEO81_02275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEO81_02285	COG0653	protein targeting
LEO81_02295	COG0494	nUDIX hydrolase
LEO81_02300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LEO81_02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LEO81_02320	COG1459	type II secretion system
LEO81_02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO81_02350	COG2186	Transcriptional regulator
LEO81_02355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LEO81_02360	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO81_02365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO81_02370	COG0840	transmembrane signaling receptor activity
LEO81_02375	COG0840	transmembrane signaling receptor activity
LEO81_02380	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO81_02385	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEO81_02390	COG2200	EAL domain
LEO81_02400	COG1280	lysine exporter protein (LysE YggA)
LEO81_02410	COG0523	cobalamin synthesis protein
LEO81_02415	COG0477	Major facilitator Superfamily
LEO81_02430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEO81_02435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEO81_02470	COG3314	Sporulation integral membrane protein YlbJ
LEO81_02475	COG0784	Response regulator, receiver
LEO81_02475	COG0835	chemotaxis
LEO81_02485	COG1444	tRNA N-acetyltransferase activity
LEO81_02510	COG1803	Methylglyoxal synthase
LEO81_02525	COG0252	asparaginase activity
LEO81_02540	COG1609	Transcriptional regulator
LEO81_02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO81_02545	COG1263	PTS System
LEO81_02550	COG0366	Alpha amylase catalytic
LEO81_02555	COG0110	maltose O-acetyltransferase activity
LEO81_02580	COG1012	belongs to the aldehyde dehydrogenase family
LEO81_02585	COG1177	transmembrane transport
LEO81_02590	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO81_02595	COG3842	ATPase activity
LEO81_02600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEO81_02605	COG0583	DNA-binding transcription factor activity
LEO81_02610	COG1757	Na H antiporter
LEO81_02650	COG0297	glycogen (starch) synthase activity
LEO81_02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO81_02660	COG2813	Specifically methylates the guanine in position
LEO81_02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO81_02670	COG5001	Diguanylate cyclase
LEO81_02670	COG4251	negative regulation of phosphorylation
LEO81_02670	COG3706	GGDEF domain
LEO81_02670	COG2203	Gaf domain
LEO81_02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO81_02690	COG2995	paraquat-inducible protein a
LEO81_02695	COG3008	intermembrane lipid transfer
LEO81_02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO81_02700	COG3009	Protein conserved in bacteria
LEO81_02720	COG3240	lipase activity
LEO81_02725	COG3111	PFAM Bacterial OB fold (BOF) protein
LEO81_02735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LEO81_02740	COG1194	a g-specific adenine glycosylase
LEO81_02750	COG3409	Peptidoglycan-binding domain 1 protein
LEO81_02750	COG3267	Type II secretory pathway component ExeA
LEO81_02755	COG0617	tRNA 3'-terminal CCA addition
LEO81_02770	COG1346	cytolysis
LEO81_02775	COG1380	Effector of murein hydrolase LrgA
LEO81_02780	COG0583	DNA-binding transcription factor activity
LEO81_02810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEO81_02815	COG0306	phosphate transporter
LEO81_02820	COG1392	Phosphate transport regulator
LEO81_02835	COG1560	Kdo2-lipid A biosynthetic process
LEO81_02840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEO81_02840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEO81_02845	COG1538	Outer membrane efflux protein
LEO81_02850	COG0494	nUDIX hydrolase
LEO81_02855	COG3151	Protein conserved in bacteria
LEO81_02865	COG3150	esterase
LEO81_02870	COG1051	belongs to the nudix hydrolase family
LEO81_02885	COG1566	PFAM secretion protein HlyD family protein
LEO81_02890	COG1289	transmembrane transporter activity
LEO81_02910	COG0583	DNA-binding transcription factor activity
LEO81_02920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO81_02960	COG0484	heat shock protein binding
LEO81_02970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO81_02990	COG0204	Acyl-transferase
LEO81_02995	COG1842	Phage shock protein A
LEO81_03010	COG2827	Endonuclease containing a URI domain
LEO81_03020	COG2962	Rard protein
LEO81_03025	COG1573	uracil-dna glycosylase
LEO81_03030	COG0697	spore germination
LEO81_03035	COG0583	DNA-binding transcription factor activity
LEO81_03040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEO81_03045	COG1121	(ABC) transporter
LEO81_03050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LEO81_03070	COG0739	heme binding
LEO81_03080	COG3068	Protein conserved in bacteria
LEO81_03100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEO81_03105	COG1546	Belongs to the CinA family
LEO81_03110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEO81_03120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO81_03125	COG0527	aspartate kinase activity
LEO81_03130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LEO81_03165	COG1686	Belongs to the peptidase S11 family
LEO81_03170	COG0586	Pfam SNARE associated Golgi protein
LEO81_03175	COG1253	flavin adenine dinucleotide binding
LEO81_03180	COG0525	valine-tRNA ligase activity
LEO81_03185	COG2927	DNA polymerase III (CHI subunit)
LEO81_03190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO81_03195	COG0795	lipopolysaccharide-transporting ATPase activity
LEO81_03200	COG0795	lipopolysaccharide-transporting ATPase activity
LEO81_03215	COG0004	ammonium transporteR
LEO81_03220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO81_03235	COG2165	general secretion pathway protein
LEO81_03240	COG0084	hydrolase, TatD family'
LEO81_03245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO81_03255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO81_03260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LEO81_03265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEO81_03270	COG0813	purine-nucleoside phosphorylase activity
LEO81_03275	COG3447	MASE1 domain protein
LEO81_03275	COG5001	Diguanylate cyclase
LEO81_03275	COG5002	protein histidine kinase activity
LEO81_03285	COG0560	Phosphoserine phosphatase
LEO81_03320	COG0776	regulation of translation
LEO81_03335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO81_03340	COG0735	belongs to the Fur family
LEO81_03365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEO81_03370	COG0513	Belongs to the DEAD box helicase family
LEO81_03375	COG3022	response to hydroperoxide
LEO81_03390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEO81_03395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEO81_03400	COG0762	integral membrane protein
LEO81_03405	COG1872	DUF167
LEO81_03420	COG4166	transmembrane transport
LEO81_03430	COG0110	maltose O-acetyltransferase activity
LEO81_03440	COG1024	Enoyl-CoA hydratase
LEO81_03455	COG4221	oxidoreductase activity
LEO81_03460	COG0442	prolyl-tRNA aminoacylation
LEO81_03465	COG0840	transmembrane signaling receptor activity
LEO81_03470	COG0632	four-way junction helicase activity
LEO81_03475	COG2255	four-way junction helicase activity
LEO81_03480	COG1271	oxidase subunit
LEO81_03485	COG1294	oxidase, subunit
LEO81_03490	COG4890	Cyd operon protein YbgT
LEO81_03495	COG3790	cyd operon protein YbgE
LEO81_03500	COG0824	Thioesterase
LEO81_03505	COG0811	peptide transport
LEO81_03520	COG0823	Involved in the tonB-independent uptake of proteins
LEO81_03525	COG2885	chlorophyll binding
LEO81_03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LEO81_03605	COG0840	transmembrane signaling receptor activity
LEO81_03610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEO81_03615	COG0676	glucose-6-phosphate 1-epimerase activity
LEO81_03620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO81_03625	COG1640	4-alpha-glucanotransferase
LEO81_03630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEO81_03650	COG1051	belongs to the nudix hydrolase family
LEO81_03655	COG2130	NADP-dependent
LEO81_03660	COG1846	Transcriptional regulator
LEO81_03690	COG0561	phosphatase activity
LEO81_03705	COG0733	neurotransmitter:sodium symporter activity
LEO81_03715	COG0733	neurotransmitter:sodium symporter activity
LEO81_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO81_03755	COG1794	racemase activity, acting on amino acids and derivatives
LEO81_03770	COG2731	YhcH YjgK YiaL family protein
LEO81_03780	COG0668	transmembrane transport
LEO81_03790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO81_03795	COG0789	Transcriptional regulator
LEO81_03805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEO81_03825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LEO81_03835	COG0488	(ABC) transporter
LEO81_03840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO81_03840	COG0517	IMP dehydrogenase activity
LEO81_03845	COG1585	Membrane protein implicated in regulation of membrane protease activity
LEO81_03850	COG0330	HflC and HflK could
LEO81_03855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO81_03855	COG1648	precorrin-2 dehydrogenase activity
LEO81_03860	COG0175	sulfate reduction
LEO81_03865	COG2895	sulfate adenylyltransferase (ATP) activity
LEO81_03870	COG0471	metal ion transport
LEO81_03870	COG3273	potassium ion transport
LEO81_03875	COG0529	Catalyzes the synthesis of activated sulfate
LEO81_03915	COG0625	glutathione transferase activity
LEO81_03920	COG0840	transmembrane signaling receptor activity
LEO81_03940	COG1136	(ABC) transporter
LEO81_03955	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LEO81_03970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEO81_03975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO81_03980	COG0163	prenyltransferase activity
LEO81_03995	COG1131	(ABC) transporter
LEO81_04000	COG0842	Transport permease protein
LEO81_04005	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LEO81_04010	COG1924	4 iron, 4 sulfur cluster binding
LEO81_04030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEO81_04035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEO81_04050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO81_04055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LEO81_04060	COG1489	DNA binding
LEO81_04070	COG1643	Atp-dependent helicase
LEO81_04075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO81_04080	COG0346	lactoylglutathione lyase activity
LEO81_04090	COG2076	Multidrug Resistance protein
LEO81_04100	COG0784	Response regulator, receiver
LEO81_04100	COG3437	response regulator, receiver
LEO81_04110	COG0671	phosphoesterase, PA-phosphatase related
LEO81_04125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEO81_04130	COG0038	chloride channel
LEO81_04140	COG0316	Belongs to the HesB IscA family
LEO81_04170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LEO81_04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_04215	COG0745	RESPONSE REGULATOR receiver
LEO81_04220	COG3104	oligopeptide transport
LEO81_04225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEO81_04230	COG1555	photosystem II stabilization
LEO81_04235	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO81_04240	COG2350	Protein conserved in bacteria
LEO81_04245	COG2917	probably involved in intracellular septation
LEO81_04250	COG0076	glutamate decarboxylase activity
LEO81_04255	COG1272	protein, Hemolysin III
LEO81_04260	COG2985	domain, Protein
LEO81_04260	COG0569	domain protein
LEO81_04270	COG0564	pseudouridine synthase activity
LEO81_04275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO81_04310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO81_04320	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LEO81_04330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEO81_04340	COG4143	(ABC) transporter
LEO81_04355	COG0066	3-isopropylmalate dehydratase activity
LEO81_04360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEO81_04365	COG0473	3-isopropylmalate dehydrogenase activity
LEO81_04370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO81_04380	COG0671	phosphoesterase, PA-phosphatase related
LEO81_04395	COG0028	Belongs to the TPP enzyme family
LEO81_04400	COG0440	acetolactate synthase activity
LEO81_04405	COG0280	phosphate acetyltransferase
LEO81_04405	COG0857	belongs to the CobB CobQ family
LEO81_04410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO81_04420	COG3013	Belongs to the UPF0304 family
LEO81_04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEO81_04430	COG2716	regulation of RNA biosynthetic process
LEO81_04440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LEO81_04445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEO81_04460	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LEO81_04480	COG0784	Response regulator, receiver
LEO81_04480	COG5002	protein histidine kinase activity
LEO81_04480	COG2198	Histidine kinase
LEO81_04505	COG0840	transmembrane signaling receptor activity
LEO81_04515	COG1464	Belongs to the NlpA lipoprotein family
LEO81_04520	COG2011	ABC-type metal ion transport system permease component
LEO81_04525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEO81_04545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEO81_04545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEO81_04550	COG0802	atpase or kinase
LEO81_04560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO81_04565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEO81_04570	COG1923	regulation of RNA biosynthetic process
LEO81_04575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEO81_04580	COG0330	HflC and HflK could
LEO81_04585	COG0330	HflC and HflK could
LEO81_04590	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LEO81_04595	COG0142	geranyltranstransferase activity
LEO81_04600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEO81_04605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEO81_04610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEO81_04615	COG3314	Sporulation integral membrane protein YlbJ
LEO81_04620	COG0318	PFAM AMP-dependent synthetase and ligase
LEO81_04635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO81_04640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEO81_04650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO81_04655	COG2967	ApaG domain
LEO81_04660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEO81_04665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEO81_04675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO81_04680	COG3178	'Phosphotransferase
LEO81_04685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEO81_04690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO81_04695	COG2252	PERMEase
LEO81_04705	COG0488	(ABC) transporter
LEO81_04720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO81_04725	COG0741	lytic transglycosylase activity
LEO81_04750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LEO81_04755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO81_04765	COG3721	Heme iron utilization protein
LEO81_04770	COG0748	coenzyme F420 binding
LEO81_04790	COG4771	TonB-dependent receptor
LEO81_04795	COG2814	Major facilitator Superfamily
LEO81_04805	COG3655	Transcriptional regulator
LEO81_04815	COG2202	Pas domain
LEO81_04815	COG2205	protein histidine kinase activity
LEO81_04830	COG3397	chitin binding
LEO81_04845	COG1765	OsmC-like protein
LEO81_04860	COG3954	Phosphoribulokinase
LEO81_04865	COG2076	Multidrug Resistance protein
LEO81_04870	COG2076	Multidrug Resistance protein
LEO81_04875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEO81_04880	COG0726	polysaccharide deacetylase
LEO81_04885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO81_04885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO81_04890	COG0463	Glycosyl transferase, family 2
LEO81_04895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO81_04905	COG3089	Belongs to the UPF0270 family
LEO81_04910	COG0429	hydrolase of the alpha beta-hydrolase fold
LEO81_04915	COG0784	Response regulator, receiver
LEO81_04915	COG0835	chemotaxis
LEO81_04930	COG1047	Peptidyl-prolyl cis-trans
LEO81_04935	COG2900	Belongs to the SlyX family
LEO81_04945	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO81_04950	COG2204	response regulator
LEO81_04970	COG0737	Belongs to the 5'-nucleotidase family
LEO81_04975	COG2200	EAL domain
LEO81_04990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO81_04995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_05000	COG0826	peptidase U32
LEO81_05005	COG2199	diguanylate cyclase activity
LEO81_05005	COG2203	Gaf domain
LEO81_05005	COG2200	EAL domain
LEO81_05030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO81_05035	COG2201	protein-glutamate methylesterase activity
LEO81_05040	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LEO81_05050	COG0840	transmembrane signaling receptor activity
LEO81_05055	COG0835	chemotaxis
LEO81_05065	COG0643	Histidine kinase
LEO81_05065	COG2198	Histidine kinase
LEO81_05075	COG0745	RESPONSE REGULATOR receiver
LEO81_05085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO81_05095	COG1280	lysine exporter protein (LysE YggA)
LEO81_05100	COG0826	peptidase U32
LEO81_05130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEO81_05155	COG0300	oxidoreductase activity
LEO81_05195	COG0077	Prephenate dehydratase
LEO81_05195	COG1605	Chorismate mutase
LEO81_05225	COG3272	Protein of unknown function (DUF1722)
LEO81_05230	COG0789	Transcriptional regulator
LEO81_05235	COG0415	Belongs to the DNA photolyase family
LEO81_05245	COG4221	oxidoreductase activity
LEO81_05260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEO81_05285	COG0783	Belongs to the Dps family
LEO81_05295	COG1151	hydroxylamine reductase activity
LEO81_05305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO81_05310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO81_05310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO81_05325	COG2771	luxR family
LEO81_05385	COG0693	protein deglycase activity
LEO81_05390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEO81_05395	COG1666	GTP binding
LEO81_05400	COG3248	Nucleoside-binding outer membrane protein
LEO81_05405	COG2211	Major facilitator Superfamily
LEO81_05415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO81_05425	COG2813	Specifically methylates the guanine in position
LEO81_05430	COG0271	Belongs to the BolA IbaG family
LEO81_05435	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO81_05440	COG1805	sodium ion transport
LEO81_05445	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO81_05450	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO81_05455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO81_05460	COG2871	sodium ion transport
LEO81_05465	COG1477	protein flavinylation
LEO81_05480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO81_05485	COG0840	transmembrane signaling receptor activity
LEO81_05490	COG0583	DNA-binding transcription factor activity
LEO81_05500	COG2363	Small membrane protein
LEO81_05505	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEO81_05515	COG0473	3-isopropylmalate dehydrogenase activity
LEO81_05520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO81_05525	COG1611	Belongs to the LOG family
LEO81_05540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO81_05540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO81_05550	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LEO81_05575	COG3098	single-species biofilm formation
LEO81_05580	COG0564	pseudouridine synthase activity
LEO81_05610	COG2171	N-acyltransferase activity
LEO81_05615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEO81_05620	COG0024	Methionine aminopeptidase
LEO81_05625	COG0052	Belongs to the universal ribosomal protein uS2 family
LEO81_05630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEO81_05635	COG0528	UMP kinase activity
LEO81_05640	COG0233	cytoplasmic translational termination
LEO81_05645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEO81_05650	COG0575	Belongs to the CDS family
LEO81_05655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEO81_05660	COG0750	zinc metalloprotease
LEO81_05675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO81_05680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO81_05685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO81_05690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO81_05695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEO81_05705	COG0825	malonyl-CoA metabolic process
LEO81_05710	COG3710	Transcriptional regulator
LEO81_05715	COG0531	amino acid
LEO81_05720	COG1982	Orn Lys Arg decarboxylase major
LEO81_05725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO81_05740	COG0814	amino acid
LEO81_05745	COG0531	amino acid
LEO81_05755	COG0488	(ABC) transporter
LEO81_05765	COG3590	peptidase
LEO81_05775	COG3706	GGDEF domain
LEO81_05810	COG0366	Alpha amylase catalytic
LEO81_05825	COG0463	Glycosyl transferase, family 2
LEO81_05840	COG2989	Protein conserved in bacteria
LEO81_05845	COG3108	Peptidase M15
LEO81_05855	COG2860	membrane
LEO81_05865	COG1196	nuclear chromosome segregation
LEO81_05870	COG3115	cell septum assembly
LEO81_05875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEO81_05885	COG1328	CTP reductase activity
LEO81_05890	COG0602	queuosine metabolic process
LEO81_05920	COG1566	PFAM secretion protein HlyD family protein
LEO81_05925	COG1846	Transcriptional regulator
LEO81_05940	COG0281	malic enzyme
LEO81_05945	COG3290	protein histidine kinase activity
LEO81_05950	COG4565	transcriptional regulatory protein
LEO81_05955	COG0697	spore germination
LEO81_05970	COG3284	Transcriptional regulator
LEO81_05975	COG1960	acyl-CoA dehydrogenase activity
LEO81_05980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LEO81_05985	COG0346	lactoylglutathione lyase activity
LEO81_05990	COG0745	RESPONSE REGULATOR receiver
LEO81_05995	COG5002	protein histidine kinase activity
LEO81_06020	COG3142	Participates in the control of copper homeostasis
LEO81_06030	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO81_06035	COG1131	(ABC) transporter
LEO81_06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_06055	COG4597	amino acid ABC transporter
LEO81_06060	COG0765	amino acid transport
LEO81_06065	COG1126	abc transporter atp-binding protein
LEO81_06075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LEO81_06095	COG0019	diaminopimelate decarboxylase activity
LEO81_06100	COG1115	amino acid carrier protein
LEO81_06105	COG0095	Lipoate-protein ligase
LEO81_06110	COG2233	PERMEase
LEO81_06125	COG0534	Mate efflux family protein
LEO81_06130	COG2207	Transcriptional regulator
LEO81_06135	COG0281	malic enzyme
LEO81_06165	COG0733	neurotransmitter:sodium symporter activity
LEO81_06170	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO81_06180	COG1566	PFAM secretion protein HlyD family protein
LEO81_06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO81_06195	COG1032	radical SAM domain protein
LEO81_06225	COG3152	Membrane
LEO81_06245	COG0673	inositol 2-dehydrogenase activity
LEO81_06250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEO81_06255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO81_06260	COG0739	heme binding
LEO81_06260	COG0741	lytic transglycosylase activity
LEO81_06260	COG1196	nuclear chromosome segregation
LEO81_06265	COG0366	Alpha amylase catalytic
LEO81_06285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO81_06295	COG0788	formyltetrahydrofolate deformylase activity
LEO81_06300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO81_06310	COG3118	belongs to the thioredoxin family
LEO81_06315	COG2091	lysine biosynthetic process via aminoadipic acid
LEO81_06320	COG0791	NLP P60 protein
LEO81_06325	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LEO81_06340	COG1376	ErfK ybiS ycfS ynhG family protein
LEO81_06340	COG1388	LysM domain
LEO81_06360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO81_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_06375	COG5002	protein histidine kinase activity
LEO81_06390	COG0583	DNA-binding transcription factor activity
LEO81_06395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO81_06400	COG0243	molybdopterin cofactor binding
LEO81_06410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEO81_06420	COG1960	acyl-CoA dehydrogenase activity
LEO81_06435	COG0469	pyruvate kinase activity
LEO81_06440	COG1737	Transcriptional regulator
LEO81_06460	COG2274	protein secretion by the type I secretion system
LEO81_06470	COG2274	protein secretion by the type I secretion system
LEO81_06480	COG2994	toxin metabolic process
LEO81_06485	COG1073	alpha beta
LEO81_06485	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LEO81_06485	COG3064	Membrane
LEO81_06490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO81_06510	COG1342	Belongs to the UPF0251 family
LEO81_06515	COG0640	Transcriptional regulator
LEO81_06530	COG0798	PFAM Bile acid sodium symporter
LEO81_06535	COG1393	Belongs to the ArsC family
LEO81_06550	COG1677	Flagellar hook-basal body complex protein FliE
LEO81_06560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEO81_06615	COG1684	flagellar biosynthetic protein fliR
LEO81_06625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEO81_06650	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LEO81_06655	COG2198	Histidine kinase
LEO81_06655	COG0643	Histidine kinase
LEO81_06655	COG0784	Response regulator, receiver
LEO81_06660	COG2201	protein-glutamate methylesterase activity
LEO81_06665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO81_06675	COG1192	Involved in chromosome partitioning
LEO81_06685	COG0835	chemotaxis
LEO81_06700	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO81_06705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO81_06710	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO81_06715	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEO81_06720	COG1138	Cytochrome C-type biogenesis protein
LEO81_06725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO81_06730	COG3088	subunit of a heme lyase
LEO81_06730	COG4235	cytochrome complex assembly
LEO81_06735	COG0457	Tetratricopeptide repeat
LEO81_06750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEO81_06755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO81_06755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO81_06770	COG0259	pyridoxamine-phosphate oxidase activity
LEO81_06775	COG0625	glutathione transferase activity
LEO81_06785	COG3153	acetyltransferase
LEO81_06795	COG2850	peptidyl-arginine hydroxylation
LEO81_06800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEO81_06805	COG2915	High frequency lysogenization protein hflD homolog
LEO81_06810	COG0482	sulfurtransferase activity
LEO81_06820	COG1187	pseudouridine synthase activity
LEO81_06830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_06830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_06830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_06840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_06840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_06850	COG0456	acetyltransferase
LEO81_06860	COG0789	Transcriptional regulator
LEO81_06865	COG1902	pentaerythritol trinitrate reductase activity
LEO81_06865	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO81_06870	COG1609	Transcriptional regulator
LEO81_06875	COG1263	PTS System
LEO81_06875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO81_06880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO81_06890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_06910	COG2207	Transcriptional regulator
LEO81_06915	COG0538	isocitrate dehydrogenase activity
LEO81_06920	COG0659	secondary active sulfate transmembrane transporter activity
LEO81_06930	COG3048	D-serine ammonia-lyase activity
LEO81_06935	COG0583	DNA-binding transcription factor activity
LEO81_06940	COG1940	carbohydrate kinase activity
LEO81_06945	COG0514	ATP-dependent DNA helicase (RecQ)
LEO81_06950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO81_07005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEO81_07010	COG2867	negative regulation of translational initiation
LEO81_07015	COG2914	Belongs to the UPF0125 (RnfH) family
LEO81_07020	COG0702	epimerase
LEO81_07025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO81_07030	COG1454	alcohol dehydrogenase
LEO81_07040	COG0564	pseudouridine synthase activity
LEO81_07070	COG1280	lysine exporter protein (LysE YggA)
LEO81_07090	COG3263	regulation of cellular component size
LEO81_07100	COG1876	peptidase activity
LEO81_07105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO81_07110	COG1393	Belongs to the ArsC family
LEO81_07115	COG0583	DNA-binding transcription factor activity
LEO81_07125	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO81_07140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO81_07145	COG0017	Asparaginyl-tRNA synthetase
LEO81_07165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO81_07170	COG0156	8-amino-7-oxononanoate synthase activity
LEO81_07175	COG1073	alpha beta
LEO81_07175	COG2226	methyltransferase
LEO81_07180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEO81_07185	COG0501	Belongs to the peptidase M48B family
LEO81_07195	COG0633	Ferredoxin
LEO81_07195	COG3217	Mosc domain protein beta barrel domain protein
LEO81_07195	COG0633	Ferredoxin
LEO81_07195	COG3217	Mosc domain protein beta barrel domain protein
LEO81_07205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LEO81_07205	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO81_07205	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO81_07205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO81_07210	COG2366	antibiotic biosynthetic process
LEO81_07215	COG1917	Cupin 2, conserved barrel domain protein
LEO81_07215	COG2169	Transcriptional regulator
LEO81_07220	COG2841	Protein conserved in bacteria
LEO81_07230	COG0534	Mate efflux family protein
LEO81_07270	COG1309	transcriptional regulator
LEO81_07285	COG0791	NLP P60 protein
LEO81_07295	COG0583	DNA-binding transcription factor activity
LEO81_07300	COG0450	alkyl hydroperoxide reductase
LEO81_07320	COG0500	methyltransferase
LEO81_07325	COG4106	trans-aconitate 2-methyltransferase activity
LEO81_07330	COG1801	Protein of unknown function DUF72
LEO81_07335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEO81_07340	COG0217	transcriptional regulatory protein
LEO81_07345	COG2194	sulfuric ester hydrolase activity
LEO81_07350	COG1940	carbohydrate kinase activity
LEO81_07350	COG1846	Transcriptional regulator
LEO81_07355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO81_07360	COG0363	glucosamine-6-phosphate deaminase activity
LEO81_07365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO81_07365	COG2190	(PTS) system
LEO81_07365	COG1263	PTS System
LEO81_07375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO81_07380	COG0735	belongs to the Fur family
LEO81_07390	COG0716	FMN binding
LEO81_07405	COG0596	Alpha beta hydrolase
LEO81_07410	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LEO81_07415	COG0033	Phosphoglucomutase
LEO81_07425	COG1846	Transcriptional regulator
LEO81_07440	COG2951	lytic endotransglycosylase activity
LEO81_07445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEO81_07450	COG4136	ATPase activity
LEO81_07460	COG4134	Bacterial extracellular solute-binding protein
LEO81_07470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO81_07480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO81_07485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO81_07495	COG0729	surface antigen
LEO81_07500	COG2911	Protein conserved in bacteria
LEO81_07520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEO81_07530	COG0741	lytic transglycosylase activity
LEO81_07545	COG1607	acyl-coa hydrolase
LEO81_07555	COG3021	interspecies interaction between organisms
LEO81_07560	COG1388	LysM domain
LEO81_07560	COG0741	lytic transglycosylase activity
LEO81_07565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO81_07570	COG2226	methyltransferase
LEO81_07575	COG0328	RNA-DNA hybrid ribonuclease activity
LEO81_07580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO81_07590	COG0784	Response regulator, receiver
LEO81_07590	COG3437	response regulator, receiver
LEO81_07595	COG1960	acyl-CoA dehydrogenase activity
LEO81_07600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO81_07605	COG0121	glutamine amidotransferase
LEO81_07625	COG0784	Response regulator, receiver
LEO81_07625	COG2205	protein histidine kinase activity
LEO81_07635	COG2197	response regulator
LEO81_07640	COG3850	Histidine kinase
LEO81_07645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO81_07650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_07650	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_07660	COG0243	molybdopterin cofactor binding
LEO81_07665	COG0437	4 iron, 4 sulfur cluster binding
LEO81_07670	COG0348	domain, Protein
LEO81_07680	COG3005	denitrification pathway
LEO81_07685	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO81_07690	COG0315	cyclic pyranopterin monophosphate synthase activity
LEO81_07695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEO81_07700	COG0314	molybdopterin synthase activity
LEO81_07715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LEO81_07720	COG2267	carboxylic ester hydrolase activity
LEO81_07725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO81_07735	COG0302	gtp cyclohydrolase
LEO81_07740	COG0840	transmembrane signaling receptor activity
LEO81_07745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEO81_07755	COG0583	DNA-binding transcription factor activity
LEO81_07785	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO81_07795	COG1166	arginine decarboxylase activity
LEO81_07805	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LEO81_07810	COG0583	DNA-binding transcription factor activity
LEO81_07830	COG0814	amino acid
LEO81_07840	COG3681	Belongs to the UPF0597 family
LEO81_07845	COG2964	Protein conserved in bacteria
LEO81_07855	COG1061	Type III restriction enzyme res subunit
LEO81_07865	COG0346	lactoylglutathione lyase activity
LEO81_07875	COG1187	pseudouridine synthase activity
LEO81_07885	COG2807	transmembrane transport
LEO81_07895	COG0583	DNA-binding transcription factor activity
LEO81_07900	COG2271	Major facilitator Superfamily
LEO81_07930	COG2979	Protein of unknown function (DUF533)
LEO81_07940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO81_07950	COG1294	oxidase, subunit
LEO81_07970	COG3220	belongs to the UPF0276 family
LEO81_07985	COG2814	Major facilitator Superfamily
LEO81_07990	COG0656	L-ascorbic acid biosynthetic process
LEO81_08025	COG0583	DNA-binding transcription factor activity
LEO81_08035	COG0840	transmembrane signaling receptor activity
LEO81_08040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEO81_08045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO81_08050	COG2271	Major facilitator Superfamily
LEO81_08055	COG1349	DNA-binding transcription factor activity
LEO81_08070	COG0584	glycerophosphoryl diester phosphodiesterase
LEO81_08075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO81_08080	COG0287	Prephenate dehydrogenase
LEO81_08080	COG1605	Chorismate mutase
LEO81_08085	COG0583	DNA-binding transcription factor activity
LEO81_08090	COG3085	chromosome segregation
LEO81_08095	COG4574	serine-type endopeptidase inhibitor activity
LEO81_08115	COG1770	oligopeptidase
LEO81_08120	COG4771	TonB-dependent receptor
LEO81_08125	COG3083	sulfuric ester hydrolase activity
LEO81_08130	COG3082	Protein of unknown function (DUF1414)
LEO81_08135	COG3081	Nucleoid-associated protein
LEO81_08145	COG1175	transmembrane transport
LEO81_08150	COG3833	ABC-type maltose transport systems, permease component
LEO81_08155	COG3842	ATPase activity
LEO81_08165	COG0596	Alpha beta hydrolase
LEO81_08180	COG0425	Belongs to the sulfur carrier protein TusA family
LEO81_08185	COG4783	chaperone-mediated protein folding
LEO81_08195	COG1393	Belongs to the ArsC family
LEO81_08215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO81_08220	COG2431	L-lysine efflux transmembrane transporter activity
LEO81_08230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_08250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO81_08260	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO81_08265	COG2373	Large extracellular alpha-helical protein
LEO81_08270	COG4953	penicillin-binding protein 1C
LEO81_08280	COG0301	tRNA thio-modification
LEO81_08280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO81_08300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO81_08335	COG1086	Polysaccharide biosynthesis protein
LEO81_08350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO81_08370	COG0483	inositol monophosphate 1-phosphatase activity
LEO81_08380	COG0625	glutathione transferase activity
LEO81_08385	COG2814	Major facilitator Superfamily
LEO81_08405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO81_08410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO81_08415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEO81_08420	COG0509	glycine decarboxylation via glycine cleavage system
LEO81_08425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO81_08425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO81_08430	COG0641	radical SAM
LEO81_08435	COG3119	arylsulfatase activity
LEO81_08450	COG3852	Histidine kinase
LEO81_08455	COG0477	Major facilitator Superfamily
LEO81_08460	COG3634	alkyl hydroperoxide reductase activity
LEO81_08470	COG0517	IMP dehydrogenase activity
LEO81_08475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEO81_08480	COG0343	queuine tRNA-ribosyltransferase activity
LEO81_08485	COG1862	Preprotein translocase
LEO81_08490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO81_08495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO81_08510	COG0826	peptidase U32
LEO81_08515	COG0826	peptidase U32
LEO81_08520	COG3154	lipid carrier protein
LEO81_08540	COG1104	cysteine desulfurase activity
LEO81_08545	COG0822	iron-sulfur transferase activity
LEO81_08555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO81_08560	COG0443	Heat shock 70 kDa protein
LEO81_08565	COG0633	Ferredoxin
LEO81_08575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO81_08580	COG0105	UTP biosynthetic process
LEO81_08585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEO81_08605	COG0124	histidyl-tRNA synthetase
LEO81_08610	COG2976	Protein conserved in bacteria
LEO81_08615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO81_08620	COG1160	GTP binding
LEO81_08625	COG1645	bacterial-type flagellum-dependent swarming motility
LEO81_08630	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO81_08635	COG0047	phosphoribosylformylglycinamidine synthase activity
LEO81_08635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEO81_08640	COG2199	diguanylate cyclase activity
LEO81_08640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO81_08655	COG1007	ATP synthesis coupled electron transport
LEO81_08660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_08670	COG0713	ATP synthesis coupled electron transport
LEO81_08675	COG0839	Belongs to the complex I subunit 6 family
LEO81_08680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_08685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LEO81_08690	COG1034	ATP synthesis coupled electron transport
LEO81_08705	COG0649	NAD binding
LEO81_08705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_08710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_08715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_08720	COG1360	Flagellar Motor Protein
LEO81_08725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO81_08745	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEO81_08765	COG0724	RNA recognition motif
LEO81_08770	COG4989	oxidoreductase activity
LEO81_08795	COG3437	response regulator, receiver
LEO81_08800	COG0583	DNA-binding transcription factor activity
LEO81_08810	COG3300	MHYT domain
LEO81_08810	COG5001	Diguanylate cyclase
LEO81_08815	COG0778	Nitroreductase
LEO81_08835	COG0583	DNA-binding transcription factor activity
LEO81_08845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO81_08850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEO81_08855	COG0539	negative regulation of cytoplasmic translation
LEO81_08860	COG0776	regulation of translation
LEO81_08870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LEO81_08890	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEO81_08895	COG0602	queuosine metabolic process
LEO81_08900	COG3530	Putative quorum-sensing-regulated virulence factor
LEO81_08905	COG2096	Adenosyltransferase
LEO81_08910	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO81_08915	COG1757	Na H antiporter
LEO81_08920	COG1435	thymidine kinase activity
LEO81_08950	COG3501	Rhs element vgr protein
LEO81_09025	COG3829	transcription factor binding
LEO81_09090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEO81_09095	COG1278	Cold shock
LEO81_09100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEO81_09105	COG0542	response to heat
LEO81_09110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEO81_09115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LEO81_09120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEO81_09125	COG3134	Outer membrane lipoprotein
LEO81_09130	COG3706	GGDEF domain
LEO81_09135	COG0492	ferredoxin-NADP+ reductase activity
LEO81_09145	COG1674	ftsk spoiiie
LEO81_09145	COG0531	amino acid
LEO81_09150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LEO81_09155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEO81_09160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEO81_09165	COG1286	toxin biosynthetic process
LEO81_09170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEO81_09180	COG4172	Belongs to the ABC transporter superfamily
LEO81_09190	COG4171	peptide transport system, permease
LEO81_09195	COG4168	peptide transport system, permease
LEO81_09205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LEO81_09210	COG1842	Phage shock protein A
LEO81_09225	COG3106	COG3106 Predicted ATPase
LEO81_09230	COG3768	UPF0283 membrane protein
LEO81_09240	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEO81_09260	COG2885	chlorophyll binding
LEO81_09265	COG0861	Integral membrane protein TerC family
LEO81_09280	COG1022	Amp-dependent synthetase and ligase
LEO81_09285	COG0295	cytidine deaminase activity
LEO81_09290	COG1346	cytolysis
LEO81_09295	COG1380	Effector of murein hydrolase LrgA
LEO81_09300	COG3345	alpha-galactosidase
LEO81_09310	COG2925	Exonuclease
LEO81_09315	COG0583	DNA-binding transcription factor activity
LEO81_09325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO81_09330	COG0254	rRNA binding
LEO81_09345	COG1451	nucleotide metabolic process
LEO81_09360	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO81_09370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LEO81_09370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO81_09375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO81_09400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LEO81_09415	COG0567	Dehydrogenase, E1 component
LEO81_09420	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO81_09425	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO81_09430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LEO81_09445	COG1280	lysine exporter protein (LysE YggA)
LEO81_09450	COG2983	Belongs to the UPF0260 family
LEO81_09455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO81_09465	COG3842	ATPase activity
LEO81_09470	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO81_09480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LEO81_09490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO81_09495	COG1882	Formate acetyltransferase
LEO81_09500	COG2116	formate transmembrane transporter activity
LEO81_09505	COG1944	ATP diphosphatase activity
LEO81_09510	COG2076	Multidrug Resistance protein
LEO81_09515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO81_09520	COG0612	Peptidase, M16
LEO81_09525	COG0626	cystathionine gamma-synthase activity
LEO81_09535	COG2910	NAD(P)H-binding
LEO81_09540	COG0583	DNA-binding transcription factor activity
LEO81_09555	COG4774	siderophore transport
LEO81_09570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEO81_09585	COG0516	GMP reductase activity
LEO81_09585	COG0517	IMP dehydrogenase activity
LEO81_09590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO81_09595	COG3046	protein related to deoxyribodipyrimidine photolyase
LEO81_09605	COG3033	Beta-eliminating lyase
LEO81_09620	COG4235	cytochrome complex assembly
LEO81_09620	COG3088	subunit of a heme lyase
LEO81_09625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO81_09630	COG1138	Cytochrome C-type biogenesis protein
LEO81_09635	COG3301	Polysulphide reductase, NrfD
LEO81_09640	COG0437	4 iron, 4 sulfur cluster binding
LEO81_09645	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO81_09660	COG0247	lactate metabolic process
LEO81_09665	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEO81_09670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEO81_09675	COG3012	SEC-C Motif Domain Protein
LEO81_09680	COG0840	transmembrane signaling receptor activity
LEO81_09685	COG1846	Transcriptional regulator
LEO81_09685	COG1940	carbohydrate kinase activity
LEO81_09690	COG3290	protein histidine kinase activity
LEO81_09695	COG4565	transcriptional regulatory protein
LEO81_09710	COG3181	Tripartite tricarboxylate transporter family receptor
LEO81_09720	COG0569	domain protein
LEO81_09720	COG2985	domain, Protein
LEO81_09730	COG0556	nucleotide-excision repair
LEO81_09740	COG0586	Pfam SNARE associated Golgi protein
LEO81_09745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO81_09750	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO81_09755	COG2186	Transcriptional regulator
LEO81_09760	COG2719	SpoVR family
LEO81_09765	COG2718	Belongs to the UPF0229 family
LEO81_09770	COG2766	serine protein kinase
LEO81_09775	COG0514	ATP-dependent DNA helicase (RecQ)
LEO81_09780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LEO81_09785	COG0814	amino acid
LEO81_09815	COG0058	SHG alpha-glucan phosphorylase activity
LEO81_09820	COG0471	metal ion transport
LEO81_09825	COG3118	belongs to the thioredoxin family
LEO81_09835	COG1132	(ABC) transporter
LEO81_09840	COG1132	(ABC) transporter
LEO81_09855	COG2501	S4 domain
LEO81_09885	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO81_09890	COG2329	Antibiotic biosynthesis monooxygenase
LEO81_09925	COG0456	acetyltransferase
LEO81_09930	COG0513	Belongs to the DEAD box helicase family
LEO81_09935	COG0386	Belongs to the glutathione peroxidase family
LEO81_09945	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEO81_09955	COG3148	PFAM DTW domain containing protein
LEO81_09960	COG0730	response to heat
LEO81_09965	COG0583	DNA-binding transcription factor activity
LEO81_09980	COG3593	DNA synthesis involved in DNA repair
LEO81_10035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO81_10040	COG1011	Hydrolase
LEO81_10045	COG1473	amidohydrolase
LEO81_10050	COG0205	6-phosphofructokinase activity
LEO81_10060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LEO81_10065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO81_10075	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LEO81_10080	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO81_10085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO81_10110	COG0242	peptide deformylase activity
LEO81_10135	COG0384	phenazine biosynthesis protein PhzF
LEO81_10150	COG2824	Alkylphosphonate utilization operon protein PhnA
LEO81_10175	COG0588	phosphoglycerate mutase activity
LEO81_10180	COG3706	GGDEF domain
LEO81_10190	COG2840	Smr protein MutS2
LEO81_10195	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO81_10200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEO81_10210	COG0513	Belongs to the DEAD box helicase family
LEO81_10225	COG0814	amino acid
LEO81_10230	COG1609	Transcriptional regulator
LEO81_10235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_10235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_10240	COG1105	Belongs to the carbohydrate kinase PfkB family
LEO81_10245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_10245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO81_10245	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LEO81_10250	COG3313	Fe-S protein
LEO81_10255	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEO81_10260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO81_10270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO81_10280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO81_10305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEO81_10310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEO81_10315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEO81_10320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEO81_10325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEO81_10330	COG0072	phenylalanine-tRNA ligase activity
LEO81_10330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO81_10335	COG0776	regulation of translation
LEO81_10340	COG0784	Response regulator, receiver
LEO81_10340	COG2205	protein histidine kinase activity
LEO81_10365	COG3300	MHYT domain
LEO81_10365	COG5001	Diguanylate cyclase
LEO81_10370	COG1609	Transcriptional regulator
LEO81_10375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO81_10380	COG1879	ABC-type sugar transport system periplasmic component
LEO81_10385	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO81_10390	COG1129	ABC transporter
LEO81_10395	COG1869	D-ribose catabolic process
LEO81_10400	COG0625	glutathione transferase activity
LEO81_10415	COG0037	tRNA processing
LEO81_10420	COG0589	response to stress
LEO81_10425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO81_10450	COG2010	Cytochrome c
LEO81_10465	COG3278	Belongs to the heme-copper respiratory oxidase family
LEO81_10475	COG1956	GAF domain-containing protein
LEO81_10480	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LEO81_10490	COG0308	aminopeptidase N
LEO81_10500	COG2902	Dehydrogenase
LEO81_10505	COG0167	dihydroorotate dehydrogenase activity
LEO81_10515	COG0116	Belongs to the methyltransferase superfamily
LEO81_10515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO81_10525	COG0488	(ABC) transporter
LEO81_10540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO81_10545	COG1067	ATP-dependent peptidase activity
LEO81_10585	COG4128	Pfam Zonular occludens toxin
LEO81_10665	COG3141	response to X-ray
LEO81_10675	COG4221	oxidoreductase activity
LEO81_10720	COG0372	Belongs to the citrate synthase family
LEO81_10725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LEO81_10735	COG2995	paraquat-inducible protein a
LEO81_10740	COG3008	intermembrane lipid transfer
LEO81_10745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO81_10745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEO81_10760	COG0084	hydrolase, TatD family'
LEO81_10765	COG0470	DNA polymerase III
LEO81_10770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEO81_10775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEO81_10780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEO81_10785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO81_10790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO81_10795	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO81_10810	COG0416	fatty acid biosynthetic process
LEO81_10815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEO81_10820	COG1399	metal-binding, possibly nucleic acid-binding protein
LEO81_10830	COG0424	maF-like protein
LEO81_10835	COG0546	phosphoglycolate phosphatase activity
LEO81_10840	COG0564	pseudouridine synthase activity
LEO81_10845	COG1530	ribonuclease E activity
LEO81_10850	COG0306	phosphate transporter
LEO81_10855	COG0717	Belongs to the dCTP deaminase family
LEO81_10860	COG0572	uridine kinase
LEO81_10865	COG0489	protein tyrosine kinase activity
LEO81_10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO81_10870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO81_10875	COG0625	glutathione transferase activity
LEO81_10880	COG1254	Belongs to the acylphosphatase family
LEO81_10885	COG0840	transmembrane signaling receptor activity
LEO81_10890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO81_10900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO81_10915	COG0709	Synthesizes selenophosphate from selenide and ATP
LEO81_10920	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LEO81_10925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO81_10930	COG3437	response regulator, receiver
LEO81_10940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEO81_10950	COG1643	Atp-dependent helicase
LEO81_10955	COG0617	tRNA 3'-terminal CCA addition
LEO81_10955	COG0517	IMP dehydrogenase activity
LEO81_10955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO81_10965	COG3314	Sporulation integral membrane protein YlbJ
LEO81_10975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LEO81_10980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEO81_10990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEO81_10995	COG2832	Protein of unknown function (DUF454)
LEO81_11000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO81_11015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LEO81_11020	COG0318	PFAM AMP-dependent synthetase and ligase
LEO81_11025	COG2267	carboxylic ester hydrolase activity
LEO81_11035	COG1214	PFAM Peptidase M22, glycoprotease
LEO81_11040	COG1199	ATP-dependent helicase activity
LEO81_11050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEO81_11055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEO81_11060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEO81_11065	COG0131	Imidazoleglycerol-phosphate dehydratase
LEO81_11065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO81_11070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO81_11075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEO81_11080	COG3437	response regulator, receiver
LEO81_11085	COG2199	diguanylate cyclase activity
LEO81_11090	COG2205	protein histidine kinase activity
LEO81_11090	COG2198	Histidine kinase
LEO81_11090	COG0784	Response regulator, receiver
LEO81_11095	COG0107	imidazoleglycerol-phosphate synthase activity
LEO81_11100	COG0140	phosphoribosyl-ATP diphosphatase activity
LEO81_11100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEO81_11110	COG2378	regulation of single-species biofilm formation
LEO81_11115	COG0318	PFAM AMP-dependent synthetase and ligase
LEO81_11120	COG1288	antiporter activity
LEO81_11130	COG3134	Outer membrane lipoprotein
LEO81_11140	COG2080	2 iron, 2 sulfur cluster binding
LEO81_11145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO81_11150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO81_11155	COG2252	PERMEase
LEO81_11160	COG0402	S-adenosylhomocysteine deaminase activity
LEO81_11165	COG2233	PERMEase
LEO81_11170	COG2080	2 iron, 2 sulfur cluster binding
LEO81_11170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO81_11175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO81_11180	COG0402	S-adenosylhomocysteine deaminase activity
LEO81_11185	COG0493	'glutamate synthase
LEO81_11185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_11190	COG2068	MobA-Related Protein
LEO81_11195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEO81_11200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LEO81_11200	COG3608	succinylglutamate desuccinylase aspartoacylase
LEO81_11205	COG0697	spore germination
LEO81_11210	COG0549	Belongs to the carbamate kinase family
LEO81_11220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO81_11225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEO81_11230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO81_11235	COG3829	transcription factor binding
LEO81_11265	COG1024	Enoyl-CoA hydratase
LEO81_11265	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO81_11270	COG0183	Belongs to the thiolase family
LEO81_11275	COG0714	Associated with various cellular activities
LEO81_11305	COG1595	DNA-templated transcription, initiation
LEO81_11320	COG2067	long-chain fatty acid transport protein
LEO81_11325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LEO81_11345	COG3123	guanosine phosphorylase activity
LEO81_11350	COG1760	l-serine dehydratase
LEO81_11355	COG1760	l-serine dehydratase
LEO81_11360	COG2951	lytic endotransglycosylase activity
LEO81_11365	COG3100	YcgL domain-containing protein
LEO81_11370	COG0850	regulation of cytokinetic process
LEO81_11375	COG2894	cell division
LEO81_11380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEO81_11385	COG3099	Belongs to the UPF0263 family
LEO81_11390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO81_11430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO81_11435	COG0697	spore germination
LEO81_11440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEO81_11445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO81_11455	COG0307	riboflavin synthase, alpha
LEO81_11465	COG0534	Mate efflux family protein
LEO81_11495	COG0417	DNA replication proofreading
LEO81_11505	COG2199	diguanylate cyclase activity
LEO81_11505	COG2203	Gaf domain
LEO81_11520	COG1560	Kdo2-lipid A biosynthetic process
LEO81_11525	COG1560	Kdo2-lipid A biosynthetic process
LEO81_11535	COG0583	DNA-binding transcription factor activity
LEO81_11540	COG0673	inositol 2-dehydrogenase activity
LEO81_11545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LEO81_11550	COG0583	DNA-binding transcription factor activity
LEO81_11560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO81_11565	COG2723	6-phospho-beta-galactosidase activity
LEO81_11570	COG0583	DNA-binding transcription factor activity
LEO81_11575	COG0438	transferase activity, transferring glycosyl groups
LEO81_11645	COG0438	transferase activity, transferring glycosyl groups
LEO81_11655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO81_11705	COG0667	Aldo Keto reductase
LEO81_11710	COG0583	DNA-binding transcription factor activity
LEO81_11715	COG0702	epimerase
LEO81_11720	COG1073	alpha beta
LEO81_11725	COG1073	alpha beta
LEO81_11740	COG0730	response to heat
LEO81_11750	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_11760	COG1024	Enoyl-CoA hydratase
LEO81_11765	COG1024	Enoyl-CoA hydratase
LEO81_11770	COG1960	acyl-CoA dehydrogenase activity
LEO81_11780	COG1960	acyl-CoA dehydrogenase activity
LEO81_11785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEO81_11820	COG1584	GPR1 FUN34 yaaH family protein
LEO81_11835	COG1115	amino acid carrier protein
LEO81_11840	COG1024	Enoyl-CoA hydratase
LEO81_11855	COG3162	membrane
LEO81_11860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO81_11865	COG0488	(ABC) transporter
LEO81_11870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO81_11875	COG0776	regulation of translation
LEO81_11880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEO81_11885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEO81_11890	COG0740	serine-type endopeptidase activity
LEO81_11895	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEO81_11905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LEO81_11910	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO81_11915	COG1136	(ABC) transporter
LEO81_11920	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO81_11930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEO81_11935	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEO81_11940	COG4166	transmembrane transport
LEO81_11945	COG0697	spore germination
LEO81_11955	COG2062	phosphohistidine phosphatase, SixA
LEO81_12000	COG0519	Catalyzes the synthesis of GMP from XMP
LEO81_12000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO81_12005	COG0516	GMP reductase activity
LEO81_12005	COG0517	IMP dehydrogenase activity
LEO81_12010	COG3158	transport of potassium into the cell
LEO81_12030	COG0697	spore germination
LEO81_12035	COG1570	exodeoxyribonuclease VII activity
LEO81_12050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO81_12055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEO81_12060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LEO81_12100	COG4771	TonB-dependent receptor
LEO81_12105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO81_12110	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO81_12115	COG1120	ATPase activity
LEO81_12125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO81_12130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO81_12140	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_12145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO81_12150	COG1535	isochorismatase
LEO81_12150	COG3433	isochorismatase activity
LEO81_12155	COG1021	2,3-dihydroxybenzoate-AMP ligase
LEO81_12175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO81_12180	COG5001	Diguanylate cyclase
LEO81_12180	COG3300	MHYT domain
LEO81_12195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO81_12200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LEO81_12205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEO81_12210	COG0563	adenylate kinase activity
LEO81_12215	COG0326	Molecular chaperone. Has ATPase activity
LEO81_12220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEO81_12245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_12255	COG3158	transport of potassium into the cell
LEO81_12260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO81_12265	COG0651	ATP synthesis coupled electron transport
LEO81_12270	COG0650	Formate hydrogenlyase subunit 4
LEO81_12275	COG3261	NADH dehydrogenase
LEO81_12275	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LEO81_12280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_12285	COG3260	NADH ubiquinone oxidoreductase 20
LEO81_12295	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO81_12305	COG1921	L-seryl-tRNASec selenium transferase activity
LEO81_12315	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LEO81_12320	COG0298	carbon dioxide binding
LEO81_12330	COG0309	Hydrogenase expression formation protein (HypE)
LEO81_12335	COG0375	protein maturation
LEO81_12345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEO81_12350	COG1124	(ABC) transporter
LEO81_12355	COG0444	Belongs to the ABC transporter superfamily
LEO81_12360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO81_12375	COG1773	rubredoxin
LEO81_12380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO81_12385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LEO81_12390	COG5557	Pfam Polysulphide reductase, NrfD
LEO81_12395	COG0437	4 iron, 4 sulfur cluster binding
LEO81_12400	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LEO81_12405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO81_12425	COG0659	secondary active sulfate transmembrane transporter activity
LEO81_12465	COG0672	)-iron permease
LEO81_12485	COG2814	Major facilitator Superfamily
LEO81_12505	COG1136	(ABC) transporter
LEO81_12510	COG0577	efflux transmembrane transporter activity
LEO81_12555	COG1139	Iron-sulfur cluster binding protein
LEO81_12560	COG0247	lactate metabolic process
LEO81_12565	COG1620	l-lactate permease
LEO81_12570	COG0583	DNA-binding transcription factor activity
LEO81_12575	COG0596	Alpha beta hydrolase
LEO81_12595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO81_12600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEO81_12600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO81_12605	COG0527	aspartate kinase activity
LEO81_12615	COG1368	sulfuric ester hydrolase activity
LEO81_12620	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEO81_12630	COG0393	Putative heavy-metal-binding
LEO81_12650	COG1252	NADH dehydrogenase
LEO81_12655	COG3150	esterase
LEO81_12660	COG2233	PERMEase
LEO81_12675	COG2354	Protein conserved in bacteria
LEO81_12690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO81_12695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO81_12730	COG0537	adenosine 5'-monophosphoramidase activity
LEO81_12745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEO81_12760	COG1301	dicarboxylic acid transport
LEO81_12770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO81_12775	COG0861	Integral membrane protein TerC family
LEO81_12785	COG0444	Belongs to the ABC transporter superfamily
LEO81_12790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO81_12795	COG0601	transmembrane transport
LEO81_12805	COG2095	MarC family integral membrane protein
LEO81_12815	COG1012	belongs to the aldehyde dehydrogenase family
LEO81_12815	COG1454	alcohol dehydrogenase
LEO81_12820	COG2199	diguanylate cyclase activity
LEO81_12820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO81_12825	COG3275	phosphorelay sensor kinase activity
LEO81_12830	COG3279	Response regulator of the LytR AlgR family
LEO81_12835	COG1966	Carbon starvation protein
LEO81_12845	COG1566	PFAM secretion protein HlyD family protein
LEO81_12850	COG1061	Type III restriction enzyme res subunit
LEO81_12855	COG2027	D-alanyl-D-alanine carboxypeptidase
LEO81_12860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEO81_12870	COG0436	Aminotransferase
LEO81_12875	COG3264	Mechanosensitive ion channel
LEO81_12875	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO81_12880	COG1288	antiporter activity
LEO81_12885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO81_12905	COG4657	Part of a membrane complex involved in electron transport
LEO81_12910	COG2878	Part of a membrane complex involved in electron transport
LEO81_12920	COG4658	electron transport chain
LEO81_12925	COG4659	FMN binding
LEO81_12930	COG4660	Part of a membrane complex involved in electron transport
LEO81_12935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEO81_12940	COG0346	lactoylglutathione lyase activity
LEO81_12955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO81_12960	COG2056	Na+-H+ antiporter family
LEO81_12970	COG2050	protein possibly involved in aromatic compounds catabolism
LEO81_12980	COG0247	lactate metabolic process
LEO81_12980	COG0277	FAD linked oxidase domain protein
LEO81_12990	COG1253	flavin adenine dinucleotide binding
LEO81_12995	COG1902	pentaerythritol trinitrate reductase activity
LEO81_13000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO81_13005	COG0647	UMP catabolic process
LEO81_13010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO81_13010	COG4651	solute:proton antiporter activity
LEO81_13020	COG0367	asparagine synthase
LEO81_13030	COG0625	glutathione transferase activity
LEO81_13040	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LEO81_13055	COG0564	pseudouridine synthase activity
LEO81_13060	COG5001	Diguanylate cyclase
LEO81_13065	COG0840	transmembrane signaling receptor activity
LEO81_13075	COG0392	lysyltransferase activity
LEO81_13075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEO81_13080	COG2194	sulfuric ester hydrolase activity
LEO81_13100	COG0670	Belongs to the BI1 family
LEO81_13105	COG1289	transmembrane transporter activity
LEO81_13110	COG2920	part of a sulfur-relay system
LEO81_13115	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LEO81_13120	COG0285	dihydrofolate synthase activity
LEO81_13125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEO81_13130	COG0101	tRNA pseudouridine synthase activity
LEO81_13140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO81_13145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO81_13150	COG0671	phosphoesterase, PA-phosphatase related
LEO81_13155	COG1464	Belongs to the NlpA lipoprotein family
LEO81_13195	COG0574	Belongs to the PEP-utilizing enzyme family
LEO81_13195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO81_13200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LEO81_13255	COG1242	4 iron, 4 sulfur cluster binding
LEO81_13260	COG0067	glutamate synthase
LEO81_13260	COG0069	glutamate synthase activity
LEO81_13260	COG0070	glutamate synthase
LEO81_13265	COG0493	'glutamate synthase
LEO81_13280	COG0789	Transcriptional regulator
LEO81_13295	COG4104	PAAR repeat-containing protein
LEO81_13305	COG0513	Belongs to the DEAD box helicase family
LEO81_13310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO81_13360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO81_13365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEO81_13370	COG0505	Belongs to the CarA family
LEO81_13375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEO81_13385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEO81_13390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEO81_13395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO81_13400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEO81_13405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO81_13410	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LEO81_13420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_13420	COG2205	protein histidine kinase activity
LEO81_13460	COG0023	Translation Initiation Factor
LEO81_13465	COG2119	membrane
LEO81_13495	COG2203	Gaf domain
LEO81_13495	COG2199	diguanylate cyclase activity
LEO81_13510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO81_13520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO81_13525	COG3301	Polysulphide reductase, NrfD
LEO81_13530	COG0437	4 iron, 4 sulfur cluster binding
LEO81_13535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO81_13580	COG4974	Belongs to the 'phage' integrase family
LEO81_13595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO81_13670	COG4695	Portal protein
LEO81_13750	COG3646	Phage regulatory protein
LEO81_13860	COG0322	excinuclease ABC activity
LEO81_13865	COG2197	response regulator
LEO81_13870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEO81_13875	COG2835	tetraacyldisaccharide 4'-kinase activity
LEO81_13880	COG1663	tetraacyldisaccharide 4'-kinase activity
LEO81_13890	COG0658	competence protein
LEO81_13890	COG2333	competence protein COMEC
LEO81_13905	COG0433	COG0433 Predicted ATPase
LEO81_13910	COG1448	Aminotransferase
LEO81_13925	COG1199	ATP-dependent helicase activity
LEO81_13935	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEO81_13940	COG0477	Major facilitator Superfamily
LEO81_13945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEO81_13970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO81_13985	COG2271	Major facilitator Superfamily
LEO81_13990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_13995	COG0765	amino acid transport
LEO81_14020	COG0531	amino acid
LEO81_14035	COG1253	flavin adenine dinucleotide binding
LEO81_14040	COG0704	Plays a role in the regulation of phosphate uptake
LEO81_14045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEO81_14050	COG0581	inorganic phosphate transmembrane transporter activity
LEO81_14055	COG0573	inorganic phosphate transmembrane transporter activity
LEO81_14060	COG0590	tRNA wobble adenosine to inosine editing
LEO81_14075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LEO81_14095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEO81_14100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEO81_14105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEO81_14110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEO81_14135	COG2716	regulation of RNA biosynthetic process
LEO81_14140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEO81_14150	COG2239	Acts as a magnesium transporter
LEO81_14160	COG1256	bacterial-type flagellum assembly
LEO81_14165	COG3951	Flagellar rod assembly protein muramidase FlgJ
LEO81_14165	COG1705	Flagellar rod assembly protein muramidase FlgJ
LEO81_14170	COG1706	bacterial-type flagellum-dependent cell motility
LEO81_14175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LEO81_14185	COG4787	bacterial-type flagellum-dependent cell motility
LEO81_14205	COG1815	bacterial-type flagellum-dependent cell motility
LEO81_14210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEO81_14215	COG0835	chemotaxis
LEO81_14215	COG0784	Response regulator, receiver
LEO81_14220	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LEO81_14235	COG0622	Phosphoesterase
LEO81_14240	COG4166	transmembrane transport
LEO81_14265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO81_14270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO81_14275	COG1882	Formate acetyltransferase
LEO81_14280	COG1349	DNA-binding transcription factor activity
LEO81_14285	COG0697	spore germination
LEO81_14315	COG1278	Cold shock
LEO81_14355	COG3132	Protein of unknown function, DUF480
LEO81_14365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO81_14385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEO81_14390	COG1596	polysaccharide export
LEO81_14420	COG0110	maltose O-acetyltransferase activity
LEO81_14440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO81_14455	COG0529	Catalyzes the synthesis of activated sulfate
LEO81_14460	COG0471	metal ion transport
LEO81_14460	COG3273	potassium ion transport
LEO81_14465	COG2895	sulfate adenylyltransferase (ATP) activity
LEO81_14480	COG1215	transferase activity, transferring glycosyl groups
LEO81_14485	COG3754	Rhamnan synthesis protein F
LEO81_14515	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEO81_14530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO81_14535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_14540	COG1309	transcriptional regulator
LEO81_14555	COG1946	Acyl-CoA thioesterase
LEO81_14565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEO81_14575	COG0009	L-threonylcarbamoyladenylate synthase
LEO81_14585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEO81_14590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO81_14590	COG0512	Glutamine amidotransferase of anthranilate synthase
LEO81_14595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO81_14600	COG0135	phosphoribosylanthranilate isomerase activity
LEO81_14600	COG0134	indole-3-glycerol-phosphate synthase activity
LEO81_14605	COG0133	tryptophan synthase activity
LEO81_14610	COG0159	tryptophan synthase activity
LEO81_14680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO81_14700	COG3311	Transcriptional regulator
LEO81_14720	COG1335	isochorismatase
LEO81_14725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LEO81_14730	COG1304	FMN binding
LEO81_14735	COG0549	Belongs to the carbamate kinase family
LEO81_14750	COG0583	DNA-binding transcription factor activity
LEO81_14785	COG2003	Belongs to the UPF0758 family
LEO81_14825	COG3381	protein complex oligomerization
LEO81_14835	COG3005	denitrification pathway
LEO81_14840	COG0745	RESPONSE REGULATOR receiver
LEO81_14850	COG1879	ABC-type sugar transport system periplasmic component
LEO81_14855	COG2205	protein histidine kinase activity
LEO81_14855	COG2198	Histidine kinase
LEO81_14855	COG0784	Response regulator, receiver
LEO81_14865	COG2814	Major facilitator Superfamily
LEO81_14870	COG0109	protoheme IX farnesyltransferase activity
LEO81_14875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LEO81_14880	COG1845	cytochrome c oxidase, subunit III
LEO81_14885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LEO81_14890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO81_14895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LEO81_14940	COG2211	Major facilitator Superfamily
LEO81_14945	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO81_14960	COG0708	Exodeoxyribonuclease III
LEO81_14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_14990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO81_15005	COG0095	Lipoate-protein ligase
LEO81_15035	COG0640	Transcriptional regulator
LEO81_15050	COG1285	pathogenesis
LEO81_15080	COG0484	heat shock protein binding
LEO81_15085	COG0443	Heat shock 70 kDa protein
LEO81_15090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEO81_15095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEO81_15100	COG0497	DNA recombination
LEO81_15105	COG1227	inorganic diphosphatase activity
LEO81_15115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_15120	COG1136	(ABC) transporter
LEO81_15120	COG0577	efflux transmembrane transporter activity
LEO81_15130	COG2375	cellular response to nickel ion
LEO81_15135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO81_15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO81_15160	COG1396	sequence-specific DNA binding
LEO81_15160	COG1917	Cupin 2, conserved barrel domain protein
LEO81_15175	COG0531	amino acid
LEO81_15185	COG0531	amino acid
LEO81_15195	COG1283	sodium-dependent phosphate transmembrane transporter activity
LEO81_15205	COG3384	dioxygenase
LEO81_15210	COG0784	Response regulator, receiver
LEO81_15210	COG2205	protein histidine kinase activity
LEO81_15210	COG5002	protein histidine kinase activity
LEO81_15215	COG3706	GGDEF domain
LEO81_15215	COG2203	Gaf domain
LEO81_15215	COG5001	Diguanylate cyclase
LEO81_15215	COG4251	negative regulation of phosphorylation
LEO81_15220	COG2205	protein histidine kinase activity
LEO81_15220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_15235	COG0813	purine-nucleoside phosphorylase activity
LEO81_15255	COG0488	(ABC) transporter
LEO81_15270	COG4319	ketosteroid isomerase
LEO81_15275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO81_15280	COG0083	homoserine kinase activity
LEO81_15290	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LEO81_15295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LEO81_15310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO81_15320	COG0745	RESPONSE REGULATOR receiver
LEO81_15335	COG4988	ABC transporter
LEO81_15340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LEO81_15360	COG1720	tRNA m6t6A37 methyltransferase activity
LEO81_15365	COG3437	response regulator, receiver
LEO81_15365	COG2770	Histidine kinase
LEO81_15380	COG0542	response to heat
LEO81_15385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEO81_15390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_15395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO81_15400	COG2190	(PTS) system
LEO81_15410	COG3038	cytochrome b561
LEO81_15420	COG0419	ATPase involved in DNA repair
LEO81_15425	COG0420	3'-5' exonuclease activity
LEO81_15435	COG2974	May be involved in recombination
LEO81_15445	COG4651	solute:proton antiporter activity
LEO81_15445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO81_15460	COG0469	pyruvate kinase activity
LEO81_15465	COG1196	nuclear chromosome segregation
LEO81_15465	COG3264	Mechanosensitive ion channel
LEO81_15475	COG2706	6-phosphogluconolactonase activity
LEO81_15490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_15510	COG0281	malic enzyme
LEO81_15520	COG0437	4 iron, 4 sulfur cluster binding
LEO81_15525	COG3383	formate dehydrogenase (NAD+) activity
LEO81_15525	COG3383	formate dehydrogenase (NAD+) activity
LEO81_15560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO81_15565	COG1910	domain protein
LEO81_15570	COG3852	Histidine kinase
LEO81_15575	COG2204	response regulator
LEO81_15585	COG4662	Binding-protein-dependent transport system inner membrane component
LEO81_15595	COG0746	molybdenum cofactor guanylyltransferase activity
LEO81_15600	COG0303	'Molybdopterin
LEO81_15605	COG1289	transmembrane transporter activity
LEO81_15610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO81_15640	COG3220	belongs to the UPF0276 family
LEO81_15680	COG2205	protein histidine kinase activity
LEO81_15680	COG0784	Response regulator, receiver
LEO81_15685	COG4166	transmembrane transport
LEO81_15690	COG0601	transmembrane transport
LEO81_15695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO81_15700	COG0444	Belongs to the ABC transporter superfamily
LEO81_15705	COG4608	Belongs to the ABC transporter superfamily
LEO81_15715	COG2971	BadF BadG BcrA BcrD
LEO81_15725	COG0840	transmembrane signaling receptor activity
LEO81_15745	COG3724	N-succinylarginine dihydrolase activity
LEO81_15750	COG0616	signal peptide processing
LEO81_15755	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_15760	COG0583	DNA-binding transcription factor activity
LEO81_15770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO81_15780	COG0583	DNA-binding transcription factor activity
LEO81_15785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEO81_15790	COG1881	PFAM PEBP family protein
LEO81_15800	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LEO81_15800	COG3408	Glycogen debranching enzyme
LEO81_15805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO81_15810	COG0739	heme binding
LEO81_15815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEO81_15830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEO81_15840	COG3091	SprT-like family
LEO81_15850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEO81_15855	COG0189	ligase activity
LEO81_15865	COG1678	Uncharacterized ACR, COG1678
LEO81_15870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEO81_15875	COG3104	oligopeptide transport
LEO81_15885	COG0714	Associated with various cellular activities
LEO81_15900	COG1115	amino acid carrier protein
LEO81_15905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO81_15920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEO81_15930	COG1301	dicarboxylic acid transport
LEO81_15935	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEO81_15940	COG2912	Transglutaminase-like superfamily
LEO81_15950	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO81_15955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEO81_15960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEO81_15965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LEO81_15970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEO81_15980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEO81_15985	COG0737	Belongs to the 5'-nucleotidase family
LEO81_15990	COG0193	aminoacyl-tRNA hydrolase activity
LEO81_15995	COG0012	GTP binding
LEO81_16040	COG0490	domain, Protein
LEO81_16040	COG0471	metal ion transport
LEO81_16050	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LEO81_16070	COG0366	Alpha amylase catalytic
LEO81_16080	COG0488	(ABC) transporter
LEO81_16110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO81_16110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO81_16110	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO81_16110	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO81_16120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO81_16130	COG1012	belongs to the aldehyde dehydrogenase family
LEO81_16140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEO81_16155	COG0180	Tryptophanyl-tRNA synthetase
LEO81_16165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEO81_16170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LEO81_16180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEO81_16185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEO81_16215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEO81_16220	COG0583	DNA-binding transcription factor activity
LEO81_16240	COG0583	DNA-binding transcription factor activity
LEO81_16255	COG0739	heme binding
LEO81_16265	COG1511	domain protein
LEO81_16265	COG3264	Mechanosensitive ion channel
LEO81_16270	COG0584	glycerophosphoryl diester phosphodiesterase
LEO81_16280	COG1053	succinate dehydrogenase
LEO81_16285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEO81_16290	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO81_16300	COG3366	ferrous iron transmembrane transporter activity
LEO81_16305	COG0700	Nucleoside recognition
LEO81_16310	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO81_16320	COG3214	Protein conserved in bacteria
LEO81_16360	COG0642	Histidine kinase
LEO81_16370	COG0516	GMP reductase activity
LEO81_16380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEO81_16385	COG3647	Membrane
LEO81_16395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO81_16415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO81_16430	COG3706	GGDEF domain
LEO81_16445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO81_16450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO81_16455	COG1702	phosphate starvation-inducible protein PhoH
LEO81_16460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEO81_16465	COG4535	Mg2 and Co2 transporter CorC
LEO81_16470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO81_16475	COG2888	peptidyl-tyrosine sulfation
LEO81_16480	COG0495	leucyl-tRNA aminoacylation
LEO81_16495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEO81_16500	COG0799	negative regulation of ribosome biogenesis
LEO81_16505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEO81_16510	COG0768	penicillin binding
LEO81_16515	COG0772	Belongs to the SEDS family
LEO81_16520	COG2951	lytic endotransglycosylase activity
LEO81_16525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO81_16530	COG1686	Belongs to the peptidase S11 family
LEO81_16535	COG2921	Belongs to the UPF0250 family
LEO81_16540	COG0321	lipoyl(octanoyl) transferase activity
LEO81_16545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEO81_16550	COG3545	Serine hydrolase
LEO81_16570	COG0789	Transcriptional regulator
LEO81_16575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEO81_16585	COG1970	mechanosensitive ion channel activity
LEO81_16595	COG4974	Belongs to the 'phage' integrase family
LEO81_16605	COG0312	modulator of DNA gyrase
LEO81_16610	COG0312	modulator of DNA gyrase
LEO81_16655	COG0114	fumarate hydratase activity
LEO81_16665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO81_16670	COG3706	GGDEF domain
LEO81_16675	COG2211	Major facilitator Superfamily
LEO81_16680	COG1185	polyribonucleotide nucleotidyltransferase activity
LEO81_16685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEO81_16690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEO81_16695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEO81_16700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEO81_16705	COG0195	Participates in both transcription termination and antitermination
LEO81_16710	COG0779	Required for maturation of 30S ribosomal subunits
LEO81_16725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEO81_16730	COG0149	triose-phosphate isomerase activity
LEO81_16735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO81_16740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEO81_16750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LEO81_16755	COG1534	Rna-binding protein
LEO81_16770	COG1360	Flagellar Motor Protein
LEO81_16775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO81_16780	COG1722	exodeoxyribonuclease VII activity
LEO81_16785	COG0142	geranyltranstransferase activity
LEO81_16790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEO81_16795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO81_16800	COG0601	transmembrane transport
LEO81_16810	COG4172	Belongs to the ABC transporter superfamily
LEO81_16815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LEO81_16820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEO81_16825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO81_16830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEO81_16845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO81_16845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO81_16850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEO81_16865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEO81_16875	COG2205	protein histidine kinase activity
LEO81_16875	COG0784	Response regulator, receiver
LEO81_16875	COG2198	Histidine kinase
LEO81_16880	COG1879	ABC-type sugar transport system periplasmic component
LEO81_16890	COG0745	RESPONSE REGULATOR receiver
LEO81_16895	COG3005	denitrification pathway
LEO81_16905	COG3381	protein complex oligomerization
LEO81_16925	COG3300	MHYT domain
LEO81_16925	COG5001	Diguanylate cyclase
LEO81_16935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO81_16940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEO81_16945	COG0511	ligase activity, forming carbon-carbon bonds
LEO81_16950	COG0439	Biotin carboxylase
LEO81_16955	COG3924	membrane
LEO81_16960	COG4145	pantothenate transmembrane transporter activity
LEO81_16965	COG2190	(PTS) system
LEO81_16965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO81_16965	COG1263	PTS System
LEO81_16970	COG0583	DNA-binding transcription factor activity
LEO81_16975	COG0604	alcohol dehydrogenase
LEO81_16980	COG2264	protein methyltransferase activity
LEO81_16995	COG0778	Nitroreductase
LEO81_17000	COG1902	pentaerythritol trinitrate reductase activity
LEO81_17000	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO81_17005	COG0616	signal peptide processing
LEO81_17025	COG3139	Protein of unknown function (DUF1315)
LEO81_17030	COG0252	asparaginase activity
LEO81_17035	COG0786	glutamate:sodium symporter activity
LEO81_17050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEO81_17055	COG0384	phenazine biosynthesis protein PhzF
LEO81_17060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO81_17065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO81_17070	COG0175	sulfate reduction
LEO81_17075	COG2113	Glycine betaine
LEO81_17080	COG4176	ABC-type proline glycine betaine transport system permease component
LEO81_17085	COG4175	Glycine betaine
LEO81_17095	COG3610	response to peptide
LEO81_17100	COG2966	Psort location CytoplasmicMembrane, score
LEO81_17110	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO81_17120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO81_17125	COG1028	Short-chain dehydrogenase reductase Sdr
LEO81_17135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO81_17185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO81_17190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO81_17225	COG1858	cytochrome C peroxidase
LEO81_17235	COG2313	pseudouridylate synthase activity
LEO81_17240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO81_17270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEO81_17285	COG1073	alpha beta
LEO81_17290	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LEO81_17295	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO81_17300	COG4608	Belongs to the ABC transporter superfamily
LEO81_17305	COG0444	Belongs to the ABC transporter superfamily
LEO81_17315	COG4239	(ABC) transporter, permease
LEO81_17320	COG4174	ABC transporter (Permease)
LEO81_17335	COG0811	peptide transport
LEO81_17340	COG0811	peptide transport
LEO81_17345	COG0848	biopolymer transport protein
LEO81_17390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO81_17395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO81_17400	COG0840	transmembrane signaling receptor activity
LEO81_17410	COG1278	Cold shock
LEO81_17445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LEO81_17450	COG1162	GTPase activity
LEO81_17455	COG0688	phosphatidylethanolamine metabolic process
LEO81_17460	COG4628	conserved protein (DUF2132)
LEO81_17480	COG5001	Diguanylate cyclase
LEO81_17480	COG3300	MHYT domain
LEO81_17485	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LEO81_17510	COG1132	(ABC) transporter
LEO81_17520	COG1404	Belongs to the peptidase S8 family
LEO81_17525	COG2897	thiosulfate sulfurtransferase activity
LEO81_17530	COG2066	Belongs to the glutaminase family
LEO81_17535	COG3171	Protein conserved in bacteria
LEO81_17540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEO81_17545	COG2234	aminopeptidase activity
LEO81_17545	COG4935	Belongs to the peptidase S8 family
LEO81_17550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO81_17555	COG2200	EAL domain
LEO81_17560	COG1090	epimerase
LEO81_17565	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LEO81_17570	COG4181	ATPase activity
LEO81_17575	COG2755	lipolytic protein G-D-S-L family
LEO81_17580	COG0835	chemotaxis
LEO81_17580	COG0784	Response regulator, receiver
LEO81_17595	COG3300	MHYT domain
LEO81_17595	COG5001	Diguanylate cyclase
LEO81_17605	COG0459	protein refolding
LEO81_17610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEO81_17615	COG0534	Mate efflux family protein
LEO81_17620	COG3030	protein affecting phage T7 exclusion by the F plasmid
LEO81_17625	COG1027	Aspartate ammonia-lyase
LEO81_17630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO81_17640	COG0477	Major facilitator Superfamily
LEO81_17650	COG3227	Zinc metalloprotease (Elastase)
LEO81_17655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO81_17660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO81_17670	COG0673	inositol 2-dehydrogenase activity
LEO81_17680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEO81_17685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO81_17690	COG3036	rescue of stalled ribosome
LEO81_17705	COG0138	bifunctional purine biosynthesis protein purh
LEO81_17730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO81_17735	COG0358	DNA primase activity
LEO81_17740	COG1610	YqeY-like protein
LEO81_17745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEO81_17750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEO81_17765	COG1238	metal cluster binding
LEO81_17770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO81_17775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEO81_17780	COG0585	pseudouridine synthase activity
LEO81_17790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEO81_17795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LEO81_17800	COG0148	phosphopyruvate hydratase activity
LEO81_17805	COG0504	CTP synthase activity
LEO81_17810	COG3956	TIGRFAM MazG family protein
LEO81_17815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO81_17820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO81_17830	COG4807	Protein conserved in bacteria
LEO81_17835	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEO81_17840	COG1349	DNA-binding transcription factor activity
LEO81_17850	COG2222	sugar isomerase
LEO81_17855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO81_17865	COG3716	PTS system mannose fructose sorbose family IID component
LEO81_17870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_17875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO81_17885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEO81_17890	COG1381	Involved in DNA repair and RecF pathway recombination
LEO81_17900	COG0571	ribonuclease III activity
LEO81_17905	COG0681	Belongs to the peptidase S26 family
LEO81_17910	COG0481	GTPase activity
LEO81_17925	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LEO81_17930	COG1595	DNA-templated transcription, initiation
LEO81_17935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEO81_17945	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LEO81_17950	COG0354	folic acid binding
LEO81_17970	COG1324	tolerance protein
LEO81_17995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO81_18005	COG0126	phosphoglycerate kinase activity
LEO81_18010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO81_18015	COG1940	carbohydrate kinase activity
LEO81_18020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEO81_18025	COG2816	NAD+ diphosphatase activity
LEO81_18035	COG4991	sh3 domain protein
LEO81_18040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO81_18055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LEO81_18070	COG2982	Protein involved in outer membrane biogenesis
LEO81_18075	COG1505	serine-type exopeptidase activity
LEO81_18080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO81_18085	COG0765	amino acid transport
LEO81_18090	COG0765	amino acid transport
LEO81_18095	COG1126	abc transporter atp-binding protein
LEO81_18100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_18105	COG0577	efflux transmembrane transporter activity
LEO81_18105	COG1136	(ABC) transporter
LEO81_18110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO81_18115	COG0745	RESPONSE REGULATOR receiver
LEO81_18120	COG2205	protein histidine kinase activity
LEO81_18155	COG2070	2-Nitropropane dioxygenase
LEO81_18180	COG1858	cytochrome C peroxidase
LEO81_18185	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LEO81_18205	COG0513	Belongs to the DEAD box helicase family
LEO81_18215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO81_18220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO81_18240	COG0154	amidase activity
LEO81_18245	COG2957	Belongs to the agmatine deiminase family
LEO81_18255	COG2852	Protein conserved in bacteria
LEO81_18265	COG1902	pentaerythritol trinitrate reductase activity
LEO81_18275	COG0456	acetyltransferase
LEO81_18295	COG5001	Diguanylate cyclase
LEO81_18310	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LEO81_18315	COG0714	Associated with various cellular activities
LEO81_18325	COG0456	acetyltransferase
LEO81_18335	COG1022	Amp-dependent synthetase and ligase
LEO81_18340	COG2918	glutathione biosynthetic process
LEO81_18345	COG0612	Peptidase, M16
LEO81_18350	COG1238	metal cluster binding
LEO81_18380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO81_18385	COG0359	binds to the 23S rRNA
LEO81_18390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEO81_18395	COG0360	Binds together with S18 to 16S ribosomal RNA
LEO81_18400	COG1914	H( )-stimulated, divalent metal cation uptake system
LEO81_18410	COG0583	DNA-binding transcription factor activity
LEO81_18420	COG2814	Major facilitator Superfamily
LEO81_18440	COG0697	spore germination
LEO81_18445	COG2153	protein acetylation
LEO81_18455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO81_18465	COG0384	phenazine biosynthesis protein PhzF
LEO81_18480	COG0557	exoribonuclease II activity
LEO81_18485	COG3706	GGDEF domain
LEO81_18490	COG1854	S-ribosylhomocysteine lyase activity
LEO81_18505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEO81_18505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO81_18565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEO81_18570	COG1047	Peptidyl-prolyl cis-trans
LEO81_18575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEO81_18580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEO81_18585	COG0196	riboflavin kinase activity
LEO81_18590	COG0728	peptidoglycan biosynthetic process
LEO81_18595	COG0268	Binds directly to 16S ribosomal RNA
LEO81_18600	COG0640	Transcriptional regulator
LEO81_18605	COG0583	DNA-binding transcription factor activity
LEO81_18615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO81_18620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEO81_18625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEO81_18635	COG1051	belongs to the nudix hydrolase family
LEO81_18640	COG3066	DNA modification
LEO81_18650	COG0335	large ribosomal subunit rRNA binding
LEO81_18655	COG0336	Belongs to the RNA methyltransferase TrmD family
LEO81_18660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEO81_18665	COG0228	four-way junction DNA binding
LEO81_18670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEO81_18675	COG4137	Cytochrome C assembly protein
LEO81_18680	COG4536	flavin adenine dinucleotide binding
LEO81_18685	COG1959	2 iron, 2 sulfur cluster binding
LEO81_18690	COG1017	nitric oxide dioxygenase activity
LEO81_18690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO81_18695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LEO81_18700	COG0039	L-malate dehydrogenase activity
LEO81_18705	COG4160	amino acid transport
LEO81_18710	COG4215	(ABC) transporter
LEO81_18715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_18720	COG1126	abc transporter atp-binding protein
LEO81_18725	COG1438	arginine binding
LEO81_18730	COG2837	iron assimilation
LEO81_18735	COG3842	ATPase activity
LEO81_18745	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO81_18750	COG0347	Belongs to the P(II) protein family
LEO81_18765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO81_18770	COG0583	DNA-binding transcription factor activity
LEO81_18785	COG1929	Belongs to the glycerate kinase type-1 family
LEO81_18790	COG2610	gluconate transmembrane transporter activity
LEO81_18795	COG3835	regulator
LEO81_18800	COG3112	Uncharacterised protein family (UPF0231)
LEO81_18830	COG0513	Belongs to the DEAD box helicase family
LEO81_18870	COG1448	Aminotransferase
LEO81_18885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO81_18890	COG1328	CTP reductase activity
LEO81_18910	COG0793	Belongs to the peptidase S41A family
LEO81_18910	COG4946	Tricorn protease homolog
LEO81_18940	COG0840	transmembrane signaling receptor activity
LEO81_18945	COG3397	chitin binding
LEO81_18950	COG0583	DNA-binding transcription factor activity
LEO81_18955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEO81_18960	COG4208	sulfate ABC transporter
LEO81_18965	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEO81_18975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEO81_18980	COG3174	membrane
LEO81_18985	COG0110	maltose O-acetyltransferase activity
LEO81_19010	COG0165	Argininosuccinate lyase
LEO81_19015	COG0137	argininosuccinate synthase activity
LEO81_19025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO81_19030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEO81_19040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEO81_19045	COG0460	homoserine dehydrogenase
LEO81_19045	COG0527	aspartate kinase activity
LEO81_19050	COG0626	cystathionine gamma-synthase activity
LEO81_19060	COG2207	Transcriptional regulator
LEO81_19060	COG3708	Transcriptional regulator
LEO81_19065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO81_19070	COG0814	amino acid
LEO81_19075	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO81_19080	COG0494	nUDIX hydrolase
LEO81_19085	COG1011	Hydrolase
LEO81_19090	COG1902	pentaerythritol trinitrate reductase activity
LEO81_19100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO81_19115	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LEO81_19125	COG3156	type II secretion system protein K
LEO81_19130	COG4795	General secretion pathway protein
LEO81_19135	COG2165	general secretion pathway protein
LEO81_19145	COG2165	general secretion pathway protein
LEO81_19150	COG1459	type II secretion system
LEO81_19155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO81_19165	COG3031	protein transport across the cell outer membrane
LEO81_19175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEO81_19180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEO81_19205	COG0456	acetyltransferase
LEO81_19210	COG3133	Outer membrane lipoprotein
LEO81_19225	COG2771	luxR family
LEO81_19230	COG3916	Acyl-homoserine-lactone synthase
LEO81_19240	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LEO81_19245	COG1309	transcriptional regulator
LEO81_19255	COG2213	PTS system mannitol-specific
LEO81_19255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO81_19260	COG0246	Mannitol dehydrogenase
LEO81_19265	COG3722	fumarate hydratase activity
LEO81_19270	COG3263	regulation of cellular component size
LEO81_19295	COG1671	Belongs to the UPF0178 family
LEO81_19310	COG1988	membrane-bound metal-dependent
LEO81_19315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO81_19320	COG0513	Belongs to the DEAD box helicase family
LEO81_19355	COG1575	Belongs to the MenA family. Type 1 subfamily
LEO81_19360	COG1169	isochorismate synthase
LEO81_19365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEO81_19370	COG0596	Alpha beta hydrolase
LEO81_19375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEO81_19380	COG1441	menaquinone biosynthetic process
LEO81_19385	COG0318	PFAM AMP-dependent synthetase and ligase
LEO81_19405	COG3121	Chaperone
LEO81_19410	COG3188	usher protein
LEO81_19420	COG3539	Fimbrial protein
LEO81_19430	COG3291	Pkd domain containing protein
LEO81_19435	COG2949	membrane
LEO81_19440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEO81_19450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO81_19455	COG5380	lipid catabolic process
LEO81_19480	COG2873	o-acetylhomoserine
LEO81_19490	COG1979	alcohol dehydrogenase
LEO81_19505	COG4221	oxidoreductase activity
LEO81_19525	COG1285	pathogenesis
LEO81_19545	COG1368	sulfuric ester hydrolase activity
LEO81_19550	COG1522	sequence-specific DNA binding
LEO81_19560	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEO81_19565	COG1418	mRNA catabolic process
LEO81_19570	COG1058	Belongs to the CinA family
LEO81_19570	COG1546	Belongs to the CinA family
LEO81_19580	COG1129	ABC transporter
LEO81_19580	COG0842	Transport permease protein
LEO81_19595	COG0561	phosphatase activity
LEO81_19600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO81_19620	COG1011	Hydrolase
LEO81_19635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEO81_19640	COG0019	diaminopimelate decarboxylase activity
LEO81_19650	COG1965	Belongs to the frataxin family
LEO81_19655	COG0400	carboxylic ester hydrolase activity
LEO81_19660	COG3072	Adenylate cyclase
LEO81_19665	COG0181	hydroxymethylbilane synthase activity
LEO81_19675	COG2959	enzyme of heme biosynthesis
LEO81_19690	COG1494	fructose-1,6-bisphosphatase
LEO81_19725	COG0456	acetyltransferase
LEO81_19730	COG1733	regulation of RNA biosynthetic process
LEO81_19750	COG3932	Exopolysaccharide synthesis, ExoD
LEO81_19755	COG0814	amino acid
LEO81_19780	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LEO81_19790	COG1192	Involved in chromosome partitioning
LEO81_19800	COG1943	Transposase
LEO81_19805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO81_19810	COG2022	thiamine diphosphate biosynthetic process
LEO81_19820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO81_19825	COG0352	thiamine-phosphate diphosphorylase activity
LEO81_19830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEO81_19850	COG0745	RESPONSE REGULATOR receiver
LEO81_19855	COG0642	Histidine kinase
LEO81_19860	COG0189	ligase activity
LEO81_19885	COG1639	'signal transduction protein
LEO81_19895	COG2321	neutral zinc metallopeptidase
LEO81_19900	COG3700	Belongs to the class B bacterial acid phosphatase family
LEO81_19920	COG1366	Belongs to the anti-sigma-factor antagonist family
LEO81_19930	COG2205	protein histidine kinase activity
LEO81_19930	COG5002	protein histidine kinase activity
LEO81_19930	COG0784	Response regulator, receiver
LEO81_19935	COG3437	response regulator, receiver
LEO81_19945	COG0477	Major facilitator Superfamily
LEO81_19960	COG0312	modulator of DNA gyrase
LEO81_19965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO81_19980	COG3164	Protein of unknown function
LEO81_19985	COG1530	ribonuclease E activity
LEO81_19990	COG0424	maF-like protein
LEO81_19995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LEO81_20000	COG1792	Involved in formation and maintenance of cell shape
LEO81_20005	COG1077	Cell shape determining protein MreB Mrl
LEO81_20035	COG4969	Belongs to the N-Me-Phe pilin family
LEO81_20040	COG2165	general secretion pathway protein
LEO81_20050	COG1459	type II secretion system
LEO81_20055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO81_20100	COG2199	diguanylate cyclase activity
LEO81_20100	COG2200	EAL domain
LEO81_20105	COG2200	EAL domain
LEO81_20110	COG0387	Pfam Sodium calcium exchanger
LEO81_20115	COG2986	histidine ammonia-lyase
LEO81_20120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LEO81_20125	COG0010	Belongs to the arginase family
LEO81_20130	COG1228	amidohydrolase
LEO81_20135	COG2188	Transcriptional regulator
LEO81_20140	COG0288	reversible hydration of carbon dioxide
LEO81_20150	COG2177	Part of the ABC transporter FtsEX involved in
LEO81_20155	COG2884	Cell division ATP-binding protein ftsE
LEO81_20160	COG0552	protein localization to endoplasmic reticulum
LEO81_20165	COG0742	ribosomal rna small subunit methyltransferase
LEO81_20190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO81_20200	COG0741	lytic transglycosylase activity
LEO81_20210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO81_20220	COG2095	MarC family integral membrane protein
LEO81_20230	COG1301	dicarboxylic acid transport
LEO81_20255	COG3714	YhhN family
LEO81_20270	COG2358	TRAP transporter, solute receptor (TAXI family
LEO81_20275	COG1770	oligopeptidase
LEO81_20290	COG4221	oxidoreductase activity
LEO81_20295	COG0583	DNA-binding transcription factor activity
LEO81_20300	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO81_20350	COG0203	ribosomal protein L17
LEO81_20355	COG0202	RNA polymerase activity
LEO81_20360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEO81_20365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEO81_20370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEO81_20375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO81_20380	COG0201	protein transport
LEO81_20385	COG0200	Binds to the 23S rRNA
LEO81_20390	COG1841	ribosomal large subunit assembly
LEO81_20395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEO81_20400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEO81_20405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEO81_20410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEO81_20415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEO81_20420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEO81_20425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEO81_20430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEO81_20435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEO81_20440	COG0255	Belongs to the universal ribosomal protein uL29 family
LEO81_20445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEO81_20450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEO81_20455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEO81_20460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEO81_20465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEO81_20470	COG0089	rRNA binding
LEO81_20475	COG0088	Forms part of the polypeptide exit tunnel
LEO81_20480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEO81_20485	COG0051	transcription antitermination factor activity, RNA binding
LEO81_20505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO81_20510	COG2183	response to ionizing radiation
LEO81_20530	COG0596	Alpha beta hydrolase
LEO81_20535	COG1040	competence protein
LEO81_20540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEO81_20540	COG0316	Belongs to the HesB IscA family
LEO81_20545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEO81_20550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LEO81_20555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO81_20560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEO81_20565	COG4942	peptidase
LEO81_20575	COG1609	Transcriptional regulator
LEO81_20580	COG0800	Aldolase
LEO81_20585	COG0129	dihydroxy-acid dehydratase activity
LEO81_20590	COG3265	gluconokinase activity
LEO81_20595	COG2610	gluconate transmembrane transporter activity
LEO81_20600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO81_20605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEO81_20615	COG0456	acetyltransferase
LEO81_20625	COG1490	D-aminoacyl-tRNA deacylase activity
LEO81_20630	COG1295	ribonuclease BN
LEO81_20635	COG1217	gtp-binding protein TYPA
LEO81_20640	COG0174	glutamine synthetase
LEO81_20650	COG3852	Histidine kinase
LEO81_20655	COG2204	response regulator
LEO81_20660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO81_20675	COG3078	GTPase activator activity
LEO81_20685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO81_20695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEO81_20700	COG0408	coproporphyrinogen oxidase activity
LEO81_20705	COG0009	L-threonylcarbamoyladenylate synthase
LEO81_20715	COG0551	DNA topoisomerase type I activity
LEO81_20720	COG2922	Belongs to the Smg family
LEO81_20725	COG0758	DNA mediated transformation
LEO81_20735	COG0242	peptide deformylase activity
LEO81_20740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO81_20745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO81_20745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO81_20750	COG0569	domain protein
LEO81_20755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO81_20760	COG1322	Protein conserved in bacteria
LEO81_20780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO81_20785	COG0686	Belongs to the AlaDH PNT family
LEO81_20790	COG0519	Catalyzes the synthesis of GMP from XMP
LEO81_20790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO81_20800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO81_20805	COG1396	sequence-specific DNA binding
LEO81_20810	COG1012	belongs to the aldehyde dehydrogenase family
LEO81_20820	COG2962	Rard protein
LEO81_20830	COG1280	lysine exporter protein (LysE YggA)
LEO81_20840	COG2391	methyltransferase activity
LEO81_20845	COG1280	lysine exporter protein (LysE YggA)
LEO81_20880	COG3161	chorismate lyase activity
LEO81_20900	COG0583	DNA-binding transcription factor activity
LEO81_20905	COG1943	Transposase
LEO81_20925	COG0210	DNA helicase
LEO81_20930	COG1744	ABC transporter substrate-binding protein PnrA-like
LEO81_20935	COG3845	ABC transporter
LEO81_20940	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEO81_20945	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEO81_20950	COG0583	DNA-binding transcription factor activity
LEO81_20970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEO81_20975	COG0385	Bile acid
LEO81_20980	COG0531	amino acid
LEO81_20985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO81_20990	COG0531	amino acid
LEO81_20995	COG2731	YhcH YjgK YiaL family protein
LEO81_21000	COG3250	beta-galactosidase activity
LEO81_21005	COG1609	Transcriptional regulator
LEO81_21040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEO81_21045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO81_21045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO81_21050	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LEO81_21055	COG3074	FtsZ-dependent cytokinesis
LEO81_21065	COG1045	serine acetyltransferase
LEO81_21075	COG0745	RESPONSE REGULATOR receiver
LEO81_21080	COG2205	protein histidine kinase activity
LEO81_21085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEO81_21090	COG0534	Mate efflux family protein
LEO81_21105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO81_21110	COG2937	Belongs to the GPAT DAPAT family
LEO81_21115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEO81_21120	COG3161	chorismate lyase activity
LEO81_21125	COG1580	Controls the rotational direction of flagella during chemotaxis
LEO81_21140	COG0604	alcohol dehydrogenase
LEO81_21145	COG1609	Transcriptional regulator
LEO81_21165	COG1519	Transferase
LEO81_21170	COG0859	PFAM glycosyl transferase family 9
LEO81_21175	COG0463	Glycosyl transferase, family 2
LEO81_21180	COG0859	PFAM glycosyl transferase family 9
LEO81_21185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEO81_21190	COG2990	Protein conserved in bacteria
LEO81_21195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEO81_21205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEO81_21210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEO81_21215	COG2003	Belongs to the UPF0758 family
LEO81_21220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEO81_21225	COG0756	dUTP diphosphatase activity
LEO81_21230	COG1309	transcriptional regulator
LEO81_21235	COG0668	transmembrane transport
LEO81_21245	COG0166	Belongs to the GPI family
LEO81_21250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEO81_21255	COG0583	DNA-binding transcription factor activity
LEO81_21270	COG1042	CoA-binding domain protein
LEO81_21270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO81_21270	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO81_21300	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LEO81_21305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO81_21310	COG1739	Uncharacterized protein family UPF0029
LEO81_21315	COG0006	proline dipeptidase activity
LEO81_21320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO81_21325	COG1024	Enoyl-CoA hydratase
LEO81_21325	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO81_21330	COG0183	Belongs to the thiolase family
LEO81_21355	COG0425	Belongs to the sulfur carrier protein TusA family
LEO81_21360	COG0251	oxidation-reduction process
LEO81_21370	COG2885	chlorophyll binding
LEO81_21380	COG2818	Glycosylase
LEO81_21385	COG0752	glycyl-tRNA synthetase alpha subunit
LEO81_21390	COG0751	glycine-tRNA ligase activity
LEO81_21430	COG0814	amino acid
LEO81_21435	COG0348	domain, Protein
LEO81_21440	COG2188	Transcriptional regulator
LEO81_21455	COG1609	Transcriptional regulator
LEO81_21495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO81_21520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEO81_21535	COG3118	belongs to the thioredoxin family
LEO81_21540	COG0513	Belongs to the DEAD box helicase family
LEO81_21545	COG0248	Ppx GppA phosphatase
LEO81_21560	COG0742	ribosomal rna small subunit methyltransferase
LEO81_21565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO81_21585	COG0084	hydrolase, TatD family'
LEO81_21590	COG0805	protein transport
LEO81_21595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO81_21605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEO81_21610	COG3165	ubiquinone biosynthetic process from chorismate
LEO81_21620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEO81_21625	COG0402	S-adenosylhomocysteine deaminase activity
LEO81_21670	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LEO81_21675	COG0848	biopolymer transport protein
LEO81_21680	COG0811	peptide transport
LEO81_21685	COG0811	peptide transport
LEO81_21695	COG2771	luxR family
LEO81_21700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEO81_21705	COG1349	DNA-binding transcription factor activity
LEO81_21710	COG0745	RESPONSE REGULATOR receiver
LEO81_21715	COG2205	protein histidine kinase activity
LEO81_21725	COG4452	Inner membrane protein CreD
LEO81_21730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO81_21735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEO81_21740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEO81_21745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEO81_21750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEO81_21755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEO81_21760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEO81_21770	COG0356	it plays a direct role in the translocation of protons across the membrane
LEO81_21780	COG1475	DNA binding
LEO81_21785	COG1192	Involved in chromosome partitioning
LEO81_21790	COG0357	Ribosomal RNA small subunit methyltransferase G
LEO81_21795	COG0445	tRNA wobble uridine modification
LEO81_21800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO81_21805	COG4774	siderophore transport
LEO81_21810	COG4615	Cyclic peptide transporter
LEO81_21815	COG1120	ATPase activity
LEO81_21825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO81_21830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEO81_21835	COG0706	membrane insertase activity
LEO81_21840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEO81_21845	COG0594	ribonuclease P activity
LEO81_21850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LEO81_21855	COG1126	abc transporter atp-binding protein