locus-tag	class	description
NRL00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NRL00_00010	COG0592	DNA-directed DNA polymerase activity
NRL00_00030	COG2378	regulation of single-species biofilm formation
NRL00_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
NRL00_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
NRL00_00045	COG3977	Valine--pyruvate aminotransferase
NRL00_00060	COG2814	Major facilitator Superfamily
NRL00_00065	COG0745	RESPONSE REGULATOR receiver
NRL00_00070	COG2205	protein histidine kinase activity
NRL00_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRL00_00105	COG4191	Histidine kinase
NRL00_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRL00_00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_00120	COG1309	transcriptional regulator
NRL00_00155	COG2271	Major facilitator Superfamily
NRL00_00175	COG0561	phosphatase activity
NRL00_00180	COG2267	carboxylic ester hydrolase activity
NRL00_00190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRL00_00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRL00_00200	COG1758	RNA polymerase activity
NRL00_00210	COG0859	PFAM glycosyl transferase family 9
NRL00_00215	COG3642	lipopolysaccharide core region biosynthetic process
NRL00_00255	COG0589	response to stress
NRL00_00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRL00_00270	COG1528	Iron-storage protein
NRL00_00275	COG2081	HI0933 family
NRL00_00280	COG2223	nitrite transmembrane transporter activity
NRL00_00290	COG3275	phosphorelay sensor kinase activity
NRL00_00295	COG3279	Response regulator of the LytR AlgR family
NRL00_00300	COG2223	nitrite transmembrane transporter activity
NRL00_00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRL00_00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRL00_00325	COG0583	DNA-binding transcription factor activity
NRL00_00335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NRL00_00365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRL00_00365	COG1042	CoA-binding domain protein
NRL00_00365	COG0045	succinate-CoA ligase (ADP-forming) activity
NRL00_00380	COG0583	DNA-binding transcription factor activity
NRL00_00385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NRL00_00390	COG0166	Belongs to the GPI family
NRL00_00400	COG0668	transmembrane transport
NRL00_00405	COG1309	transcriptional regulator
NRL00_00410	COG0756	dUTP diphosphatase activity
NRL00_00415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRL00_00420	COG2003	Belongs to the UPF0758 family
NRL00_00425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRL00_00430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRL00_00440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRL00_00445	COG2990	Protein conserved in bacteria
NRL00_00450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRL00_00455	COG0859	PFAM glycosyl transferase family 9
NRL00_00460	COG0463	Glycosyl transferase, family 2
NRL00_00465	COG0859	PFAM glycosyl transferase family 9
NRL00_00470	COG1519	Transferase
NRL00_00490	COG1609	Transcriptional regulator
NRL00_00495	COG0604	alcohol dehydrogenase
NRL00_00515	COG1580	Controls the rotational direction of flagella during chemotaxis
NRL00_00520	COG3161	chorismate lyase activity
NRL00_00525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NRL00_00530	COG2937	Belongs to the GPAT DAPAT family
NRL00_00535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRL00_00550	COG0534	Mate efflux family protein
NRL00_00555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRL00_00560	COG2205	protein histidine kinase activity
NRL00_00565	COG0745	RESPONSE REGULATOR receiver
NRL00_00575	COG1045	serine acetyltransferase
NRL00_00585	COG3074	FtsZ-dependent cytokinesis
NRL00_00590	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NRL00_00595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRL00_00595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRL00_00600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NRL00_00635	COG1609	Transcriptional regulator
NRL00_00640	COG3250	beta-galactosidase activity
NRL00_00645	COG2731	YhcH YjgK YiaL family protein
NRL00_00650	COG0531	amino acid
NRL00_00655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRL00_00660	COG0531	amino acid
NRL00_00665	COG0385	Bile acid
NRL00_00670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NRL00_00690	COG0583	DNA-binding transcription factor activity
NRL00_00695	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRL00_00700	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRL00_00705	COG3845	ABC transporter
NRL00_00710	COG1744	ABC transporter substrate-binding protein PnrA-like
NRL00_00715	COG0210	DNA helicase
NRL00_00750	COG0583	DNA-binding transcription factor activity
NRL00_00770	COG3161	chorismate lyase activity
NRL00_00805	COG1280	lysine exporter protein (LysE YggA)
NRL00_00815	COG2391	methyltransferase activity
NRL00_00825	COG1280	lysine exporter protein (LysE YggA)
NRL00_00835	COG2962	Rard protein
NRL00_00845	COG1012	belongs to the aldehyde dehydrogenase family
NRL00_00850	COG1396	sequence-specific DNA binding
NRL00_00855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRL00_00865	COG0519	Catalyzes the synthesis of GMP from XMP
NRL00_00865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRL00_00870	COG0686	Belongs to the AlaDH PNT family
NRL00_00875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRL00_00900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRL00_00905	COG0569	domain protein
NRL00_00910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRL00_00910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRL00_00915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRL00_00920	COG0242	peptide deformylase activity
NRL00_00930	COG0758	DNA mediated transformation
NRL00_00935	COG2922	Belongs to the Smg family
NRL00_00940	COG0551	DNA topoisomerase type I activity
NRL00_00950	COG0009	L-threonylcarbamoyladenylate synthase
NRL00_00955	COG0408	coproporphyrinogen oxidase activity
NRL00_00960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRL00_00970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NRL00_00980	COG3078	GTPase activator activity
NRL00_00990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRL00_00995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRL00_01000	COG2204	response regulator
NRL00_01005	COG3852	Histidine kinase
NRL00_01015	COG0174	glutamine synthetase
NRL00_01020	COG1217	gtp-binding protein TYPA
NRL00_01025	COG1295	ribonuclease BN
NRL00_01030	COG1490	D-aminoacyl-tRNA deacylase activity
NRL00_01040	COG0456	acetyltransferase
NRL00_01050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRL00_01055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRL00_01060	COG2610	gluconate transmembrane transporter activity
NRL00_01065	COG3265	gluconokinase activity
NRL00_01070	COG0129	dihydroxy-acid dehydratase activity
NRL00_01075	COG0800	Aldolase
NRL00_01080	COG1609	Transcriptional regulator
NRL00_01090	COG4942	peptidase
NRL00_01095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NRL00_01100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRL00_01105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NRL00_01110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRL00_01115	COG0316	Belongs to the HesB IscA family
NRL00_01115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NRL00_01120	COG1040	competence protein
NRL00_01125	COG0596	Alpha beta hydrolase
NRL00_01145	COG2183	response to ionizing radiation
NRL00_01150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRL00_01170	COG0051	transcription antitermination factor activity, RNA binding
NRL00_01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRL00_01180	COG0088	Forms part of the polypeptide exit tunnel
NRL00_01185	COG0089	rRNA binding
NRL00_01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRL00_01195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NRL00_01200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRL00_01205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRL00_01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NRL00_01215	COG0255	Belongs to the universal ribosomal protein uL29 family
NRL00_01220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRL00_01225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRL00_01230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NRL00_01235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRL00_01240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRL00_01245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRL00_01250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRL00_01255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NRL00_01260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRL00_01265	COG1841	ribosomal large subunit assembly
NRL00_01270	COG0200	Binds to the 23S rRNA
NRL00_01275	COG0201	protein transport
NRL00_01280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRL00_01285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRL00_01290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRL00_01295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NRL00_01300	COG0202	RNA polymerase activity
NRL00_01305	COG0203	ribosomal protein L17
NRL00_01350	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRL00_01355	COG0583	DNA-binding transcription factor activity
NRL00_01360	COG4221	oxidoreductase activity
NRL00_01375	COG1770	oligopeptidase
NRL00_01380	COG2358	TRAP transporter, solute receptor (TAXI family
NRL00_01395	COG3714	YhhN family
NRL00_01420	COG1301	dicarboxylic acid transport
NRL00_01430	COG2095	MarC family integral membrane protein
NRL00_01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRL00_01450	COG0741	lytic transglycosylase activity
NRL00_01460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRL00_01485	COG0742	ribosomal rna small subunit methyltransferase
NRL00_01490	COG0552	protein localization to endoplasmic reticulum
NRL00_01495	COG2884	Cell division ATP-binding protein ftsE
NRL00_01500	COG2177	Part of the ABC transporter FtsEX involved in
NRL00_01510	COG0288	reversible hydration of carbon dioxide
NRL00_01515	COG2188	Transcriptional regulator
NRL00_01520	COG1228	amidohydrolase
NRL00_01525	COG0010	Belongs to the arginase family
NRL00_01530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NRL00_01535	COG2986	histidine ammonia-lyase
NRL00_01540	COG0387	Pfam Sodium calcium exchanger
NRL00_01545	COG2200	EAL domain
NRL00_01550	COG2200	EAL domain
NRL00_01550	COG2199	diguanylate cyclase activity
NRL00_01595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRL00_01600	COG1459	type II secretion system
NRL00_01610	COG2165	general secretion pathway protein
NRL00_01645	COG1077	Cell shape determining protein MreB Mrl
NRL00_01650	COG1792	Involved in formation and maintenance of cell shape
NRL00_01655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NRL00_01660	COG0424	maF-like protein
NRL00_01665	COG1530	ribonuclease E activity
NRL00_01670	COG3164	Protein of unknown function
NRL00_01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRL00_01690	COG0312	modulator of DNA gyrase
NRL00_01705	COG0477	Major facilitator Superfamily
NRL00_01715	COG3437	response regulator, receiver
NRL00_01720	COG5002	protein histidine kinase activity
NRL00_01720	COG2205	protein histidine kinase activity
NRL00_01720	COG0784	Response regulator, receiver
NRL00_01725	COG2172	sigma factor antagonist activity
NRL00_01730	COG1366	Belongs to the anti-sigma-factor antagonist family
NRL00_01750	COG3700	Belongs to the class B bacterial acid phosphatase family
NRL00_01755	COG2321	neutral zinc metallopeptidase
NRL00_01765	COG1639	'signal transduction protein
NRL00_01790	COG0189	ligase activity
NRL00_01795	COG0642	Histidine kinase
NRL00_01800	COG0745	RESPONSE REGULATOR receiver
NRL00_01825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NRL00_01830	COG0352	thiamine-phosphate diphosphorylase activity
NRL00_01835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRL00_01845	COG2022	thiamine diphosphate biosynthetic process
NRL00_01850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRL00_01875	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NRL00_01900	COG0814	amino acid
NRL00_01905	COG3932	Exopolysaccharide synthesis, ExoD
NRL00_01925	COG1733	regulation of RNA biosynthetic process
NRL00_01970	COG1494	fructose-1,6-bisphosphatase
NRL00_01985	COG2959	enzyme of heme biosynthesis
NRL00_01995	COG0181	hydroxymethylbilane synthase activity
NRL00_02000	COG3072	Adenylate cyclase
NRL00_02005	COG0400	carboxylic ester hydrolase activity
NRL00_02010	COG1965	Belongs to the frataxin family
NRL00_02020	COG0019	diaminopimelate decarboxylase activity
NRL00_02025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRL00_02040	COG1011	Hydrolase
NRL00_02060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRL00_02065	COG0561	phosphatase activity
NRL00_02080	COG1129	ABC transporter
NRL00_02080	COG0842	Transport permease protein
NRL00_02090	COG1546	Belongs to the CinA family
NRL00_02090	COG1058	Belongs to the CinA family
NRL00_02095	COG1418	mRNA catabolic process
NRL00_02100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NRL00_02110	COG1522	sequence-specific DNA binding
NRL00_02115	COG1368	sulfuric ester hydrolase activity
NRL00_02135	COG1285	pathogenesis
NRL00_02155	COG4221	oxidoreductase activity
NRL00_02170	COG1979	alcohol dehydrogenase
NRL00_02180	COG2873	o-acetylhomoserine
NRL00_02190	COG4533	DNA binding
NRL00_02205	COG5380	lipid catabolic process
NRL00_02210	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NRL00_02220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRL00_02225	COG2949	membrane
NRL00_02230	COG3291	Pkd domain containing protein
NRL00_02240	COG3539	Fimbrial protein
NRL00_02250	COG3188	usher protein
NRL00_02255	COG3121	Chaperone
NRL00_02275	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_02280	COG1441	menaquinone biosynthetic process
NRL00_02285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NRL00_02290	COG0596	Alpha beta hydrolase
NRL00_02295	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NRL00_02300	COG1169	isochorismate synthase
NRL00_02305	COG1575	Belongs to the MenA family. Type 1 subfamily
NRL00_02335	COG0513	Belongs to the DEAD box helicase family
NRL00_02340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRL00_02345	COG1988	membrane-bound metal-dependent
NRL00_02360	COG1671	Belongs to the UPF0178 family
NRL00_02385	COG3263	regulation of cellular component size
NRL00_02390	COG3722	fumarate hydratase activity
NRL00_02395	COG0246	Mannitol dehydrogenase
NRL00_02400	COG2213	PTS system mannitol-specific
NRL00_02400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_02410	COG1309	transcriptional regulator
NRL00_02415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NRL00_02425	COG3916	Acyl-homoserine-lactone synthase
NRL00_02430	COG2771	luxR family
NRL00_02445	COG3133	Outer membrane lipoprotein
NRL00_02450	COG0456	acetyltransferase
NRL00_02460	COG0006	proline dipeptidase activity
NRL00_02470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NRL00_02475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NRL00_02485	COG3031	protein transport across the cell outer membrane
NRL00_02495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRL00_02500	COG1459	type II secretion system
NRL00_02505	COG2165	general secretion pathway protein
NRL00_02515	COG2165	general secretion pathway protein
NRL00_02520	COG4795	General secretion pathway protein
NRL00_02535	COG3156	type II secretion system protein K
NRL00_02545	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NRL00_02560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRL00_02565	COG1011	Hydrolase
NRL00_02570	COG0494	nUDIX hydrolase
NRL00_02575	COG1218	3'(2'),5'-bisphosphate nucleotidase
NRL00_02580	COG0814	amino acid
NRL00_02585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRL00_02590	COG2207	Transcriptional regulator
NRL00_02590	COG3708	Transcriptional regulator
NRL00_02600	COG0626	cystathionine gamma-synthase activity
NRL00_02605	COG0460	homoserine dehydrogenase
NRL00_02605	COG0527	aspartate kinase activity
NRL00_02610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NRL00_02620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NRL00_02625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRL00_02635	COG0137	argininosuccinate synthase activity
NRL00_02640	COG0165	Argininosuccinate lyase
NRL00_02670	COG0110	maltose O-acetyltransferase activity
NRL00_02675	COG3174	membrane
NRL00_02680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NRL00_02690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NRL00_02695	COG4208	sulfate ABC transporter
NRL00_02700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRL00_02705	COG0583	DNA-binding transcription factor activity
NRL00_02710	COG3397	chitin binding
NRL00_02745	COG4946	Tricorn protease homolog
NRL00_02745	COG0793	Belongs to the peptidase S41A family
NRL00_02765	COG1328	CTP reductase activity
NRL00_02770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRL00_02785	COG1448	Aminotransferase
NRL00_02825	COG0513	Belongs to the DEAD box helicase family
NRL00_02855	COG3112	Uncharacterised protein family (UPF0231)
NRL00_02860	COG3835	regulator
NRL00_02865	COG2610	gluconate transmembrane transporter activity
NRL00_02870	COG1929	Belongs to the glycerate kinase type-1 family
NRL00_02885	COG0583	DNA-binding transcription factor activity
NRL00_02890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRL00_02905	COG0347	Belongs to the P(II) protein family
NRL00_02910	COG1840	ABC-type Fe3 transport system, periplasmic component
NRL00_02920	COG3842	ATPase activity
NRL00_02925	COG2837	iron assimilation
NRL00_02930	COG1438	arginine binding
NRL00_02935	COG1126	abc transporter atp-binding protein
NRL00_02940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_02945	COG4215	(ABC) transporter
NRL00_02950	COG4160	amino acid transport
NRL00_02955	COG0039	L-malate dehydrogenase activity
NRL00_02960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NRL00_02965	COG1017	nitric oxide dioxygenase activity
NRL00_02965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRL00_02970	COG1959	2 iron, 2 sulfur cluster binding
NRL00_02975	COG4536	flavin adenine dinucleotide binding
NRL00_02980	COG4137	Cytochrome C assembly protein
NRL00_02985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRL00_02990	COG0228	four-way junction DNA binding
NRL00_02995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRL00_03000	COG0336	Belongs to the RNA methyltransferase TrmD family
NRL00_03005	COG0335	large ribosomal subunit rRNA binding
NRL00_03015	COG3066	DNA modification
NRL00_03020	COG1051	belongs to the nudix hydrolase family
NRL00_03030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NRL00_03035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NRL00_03040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRL00_03050	COG0583	DNA-binding transcription factor activity
NRL00_03055	COG0640	Transcriptional regulator
NRL00_03060	COG0268	Binds directly to 16S ribosomal RNA
NRL00_03065	COG0728	peptidoglycan biosynthetic process
NRL00_03070	COG0196	riboflavin kinase activity
NRL00_03075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRL00_03080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NRL00_03085	COG1047	Peptidyl-prolyl cis-trans
NRL00_03090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NRL00_03095	COG4970	Tfp pilus assembly protein FimT
NRL00_03150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRL00_03150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRL00_03165	COG1854	S-ribosylhomocysteine lyase activity
NRL00_03170	COG3706	GGDEF domain
NRL00_03175	COG0557	exoribonuclease II activity
NRL00_03200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRL00_03210	COG2153	protein acetylation
NRL00_03215	COG0697	spore germination
NRL00_03235	COG2814	Major facilitator Superfamily
NRL00_03245	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_03250	COG0583	DNA-binding transcription factor activity
NRL00_03260	COG1914	H( )-stimulated, divalent metal cation uptake system
NRL00_03265	COG0360	Binds together with S18 to 16S ribosomal RNA
NRL00_03270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRL00_03275	COG0359	binds to the 23S rRNA
NRL00_03280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRL00_03310	COG1238	metal cluster binding
NRL00_03315	COG0612	Peptidase, M16
NRL00_03320	COG2918	glutathione biosynthetic process
NRL00_03325	COG1022	Amp-dependent synthetase and ligase
NRL00_03335	COG0456	acetyltransferase
NRL00_03345	COG0714	Associated with various cellular activities
NRL00_03375	COG0456	acetyltransferase
NRL00_03385	COG1902	pentaerythritol trinitrate reductase activity
NRL00_03400	COG2957	Belongs to the agmatine deiminase family
NRL00_03405	COG0154	amidase activity
NRL00_03430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRL00_03435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRL00_03445	COG0513	Belongs to the DEAD box helicase family
NRL00_03470	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
NRL00_03475	COG1858	cytochrome C peroxidase
NRL00_03500	COG2070	2-Nitropropane dioxygenase
NRL00_03535	COG2205	protein histidine kinase activity
NRL00_03540	COG0745	RESPONSE REGULATOR receiver
NRL00_03545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_03550	COG0577	efflux transmembrane transporter activity
NRL00_03550	COG1136	(ABC) transporter
NRL00_03555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_03560	COG1126	abc transporter atp-binding protein
NRL00_03565	COG0765	amino acid transport
NRL00_03570	COG0765	amino acid transport
NRL00_03575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRL00_03580	COG1505	serine-type exopeptidase activity
NRL00_03585	COG2982	Protein involved in outer membrane biogenesis
NRL00_03600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NRL00_03615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRL00_03620	COG4991	sh3 domain protein
NRL00_03630	COG2816	NAD+ diphosphatase activity
NRL00_03635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NRL00_03640	COG1940	carbohydrate kinase activity
NRL00_03645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRL00_03650	COG0126	phosphoglycerate kinase activity
NRL00_03660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRL00_03680	COG4232	protein-disulfide reductase activity
NRL00_03705	COG0354	folic acid binding
NRL00_03710	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NRL00_03720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRL00_03725	COG1595	DNA-templated transcription, initiation
NRL00_03730	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NRL00_03745	COG0481	GTPase activity
NRL00_03750	COG0681	Belongs to the peptidase S26 family
NRL00_03755	COG0571	ribonuclease III activity
NRL00_03765	COG1381	Involved in DNA repair and RecF pathway recombination
NRL00_03770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NRL00_03780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRL00_03785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_03790	COG3716	PTS system mannose fructose sorbose family IID component
NRL00_03800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRL00_03805	COG2222	sugar isomerase
NRL00_03815	COG1349	DNA-binding transcription factor activity
NRL00_03820	COG3023	N-Acetylmuramoyl-L-alanine amidase
NRL00_03825	COG4807	Protein conserved in bacteria
NRL00_03835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRL00_03840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRL00_03845	COG3956	TIGRFAM MazG family protein
NRL00_03850	COG0504	CTP synthase activity
NRL00_03855	COG0148	phosphopyruvate hydratase activity
NRL00_03860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NRL00_03865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NRL00_03875	COG0585	pseudouridine synthase activity
NRL00_03880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NRL00_03885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRL00_03890	COG1238	metal cluster binding
NRL00_03895	COG1388	LysM domain
NRL00_03895	COG4942	peptidase
NRL00_03905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRL00_03910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NRL00_03915	COG1610	YqeY-like protein
NRL00_03920	COG0358	DNA primase activity
NRL00_03925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRL00_03950	COG0138	bifunctional purine biosynthesis protein purh
NRL00_03965	COG3036	rescue of stalled ribosome
NRL00_03970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRL00_03975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRL00_03985	COG0673	inositol 2-dehydrogenase activity
NRL00_03995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRL00_04000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRL00_04005	COG3227	Zinc metalloprotease (Elastase)
NRL00_04015	COG0477	Major facilitator Superfamily
NRL00_04025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRL00_04030	COG1027	Aspartate ammonia-lyase
NRL00_04035	COG3030	protein affecting phage T7 exclusion by the F plasmid
NRL00_04040	COG0534	Mate efflux family protein
NRL00_04045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRL00_04050	COG0459	protein refolding
NRL00_04060	COG3300	MHYT domain
NRL00_04060	COG5001	Diguanylate cyclase
NRL00_04070	COG0564	pseudouridine synthase activity
NRL00_04075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRL00_04110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRL00_04120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRL00_04125	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NRL00_04135	COG4143	(ABC) transporter
NRL00_04150	COG0066	3-isopropylmalate dehydratase activity
NRL00_04155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NRL00_04160	COG0473	3-isopropylmalate dehydrogenase activity
NRL00_04165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRL00_04175	COG0671	phosphoesterase, PA-phosphatase related
NRL00_04190	COG0028	Belongs to the TPP enzyme family
NRL00_04195	COG0440	acetolactate synthase activity
NRL00_04200	COG0280	phosphate acetyltransferase
NRL00_04200	COG0857	belongs to the CobB CobQ family
NRL00_04205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRL00_04215	COG3013	Belongs to the UPF0304 family
NRL00_04220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NRL00_04225	COG2716	regulation of RNA biosynthetic process
NRL00_04235	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NRL00_04240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRL00_04255	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NRL00_04275	COG2198	Histidine kinase
NRL00_04275	COG0784	Response regulator, receiver
NRL00_04275	COG5002	protein histidine kinase activity
NRL00_04300	COG0840	transmembrane signaling receptor activity
NRL00_04310	COG1464	Belongs to the NlpA lipoprotein family
NRL00_04315	COG2011	ABC-type metal ion transport system permease component
NRL00_04340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRL00_04340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NRL00_04345	COG0802	atpase or kinase
NRL00_04355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NRL00_04360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NRL00_04365	COG1923	regulation of RNA biosynthetic process
NRL00_04370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRL00_04375	COG0330	HflC and HflK could
NRL00_04380	COG0330	HflC and HflK could
NRL00_04385	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NRL00_04390	COG0142	geranyltranstransferase activity
NRL00_04395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NRL00_04400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRL00_04405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NRL00_04410	COG3314	Sporulation integral membrane protein YlbJ
NRL00_04415	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_04430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRL00_04435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRL00_04445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRL00_04450	COG2967	ApaG domain
NRL00_04455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRL00_04460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NRL00_04470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NRL00_04475	COG3178	'Phosphotransferase
NRL00_04480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRL00_04485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRL00_04490	COG2252	PERMEase
NRL00_04500	COG0488	(ABC) transporter
NRL00_04515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRL00_04520	COG0741	lytic transglycosylase activity
NRL00_04545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NRL00_04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRL00_04560	COG3721	Heme iron utilization protein
NRL00_04565	COG0748	coenzyme F420 binding
NRL00_04585	COG4771	TonB-dependent receptor
NRL00_04590	COG2814	Major facilitator Superfamily
NRL00_04600	COG3655	Transcriptional regulator
NRL00_04610	COG2202	Pas domain
NRL00_04610	COG2205	protein histidine kinase activity
NRL00_04625	COG3397	chitin binding
NRL00_04640	COG1765	OsmC-like protein
NRL00_04655	COG3954	Phosphoribulokinase
NRL00_04660	COG2076	Multidrug Resistance protein
NRL00_04665	COG2076	Multidrug Resistance protein
NRL00_04670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NRL00_04675	COG0726	polysaccharide deacetylase
NRL00_04680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRL00_04680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRL00_04685	COG0463	Glycosyl transferase, family 2
NRL00_04690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRL00_04700	COG3089	Belongs to the UPF0270 family
NRL00_04705	COG0429	hydrolase of the alpha beta-hydrolase fold
NRL00_04710	COG0784	Response regulator, receiver
NRL00_04710	COG0835	chemotaxis
NRL00_04720	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NRL00_04725	COG1047	Peptidyl-prolyl cis-trans
NRL00_04730	COG2900	Belongs to the SlyX family
NRL00_04740	COG0545	Peptidyl-prolyl cis-trans isomerase
NRL00_04745	COG2204	response regulator
NRL00_04765	COG0737	Belongs to the 5'-nucleotidase family
NRL00_04770	COG2200	EAL domain
NRL00_04785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRL00_04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_04795	COG0826	peptidase U32
NRL00_04800	COG2199	diguanylate cyclase activity
NRL00_04800	COG2200	EAL domain
NRL00_04800	COG2203	Gaf domain
NRL00_04825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRL00_04830	COG2201	protein-glutamate methylesterase activity
NRL00_04835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NRL00_04845	COG0840	transmembrane signaling receptor activity
NRL00_04850	COG0835	chemotaxis
NRL00_04860	COG0643	Histidine kinase
NRL00_04860	COG2198	Histidine kinase
NRL00_04870	COG0745	RESPONSE REGULATOR receiver
NRL00_04880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRL00_04890	COG1280	lysine exporter protein (LysE YggA)
NRL00_04895	COG0826	peptidase U32
NRL00_04925	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NRL00_04950	COG0300	oxidoreductase activity
NRL00_04960	COG0840	transmembrane signaling receptor activity
NRL00_04995	COG0077	Prephenate dehydratase
NRL00_04995	COG1605	Chorismate mutase
NRL00_05025	COG3272	Protein of unknown function (DUF1722)
NRL00_05030	COG0789	Transcriptional regulator
NRL00_05035	COG0415	Belongs to the DNA photolyase family
NRL00_05045	COG4221	oxidoreductase activity
NRL00_05060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRL00_05085	COG0783	Belongs to the Dps family
NRL00_05090	COG1151	hydroxylamine reductase activity
NRL00_05100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRL00_05105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRL00_05105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRL00_05115	COG2831	hemolysin activation secretion protein
NRL00_05180	COG2771	luxR family
NRL00_05200	COG4104	PAAR repeat-containing protein
NRL00_05245	COG0693	protein deglycase activity
NRL00_05250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRL00_05255	COG1666	GTP binding
NRL00_05260	COG3248	Nucleoside-binding outer membrane protein
NRL00_05265	COG2211	Major facilitator Superfamily
NRL00_05275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRL00_05285	COG2813	Specifically methylates the guanine in position
NRL00_05290	COG0271	Belongs to the BolA IbaG family
NRL00_05295	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRL00_05300	COG1805	sodium ion transport
NRL00_05305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRL00_05310	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRL00_05315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRL00_05320	COG2871	sodium ion transport
NRL00_05325	COG1477	protein flavinylation
NRL00_05340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRL00_05345	COG0840	transmembrane signaling receptor activity
NRL00_05350	COG0583	DNA-binding transcription factor activity
NRL00_05360	COG2363	Small membrane protein
NRL00_05365	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NRL00_05375	COG0473	3-isopropylmalate dehydrogenase activity
NRL00_05380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRL00_05385	COG1611	Belongs to the LOG family
NRL00_05400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRL00_05400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRL00_05410	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NRL00_05435	COG3098	single-species biofilm formation
NRL00_05440	COG0564	pseudouridine synthase activity
NRL00_05460	COG1263	PTS System
NRL00_05460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRL00_05470	COG2171	N-acyltransferase activity
NRL00_05475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NRL00_05480	COG0024	Methionine aminopeptidase
NRL00_05485	COG0052	Belongs to the universal ribosomal protein uS2 family
NRL00_05490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRL00_05495	COG0528	UMP kinase activity
NRL00_05500	COG0233	cytoplasmic translational termination
NRL00_05505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRL00_05510	COG0575	Belongs to the CDS family
NRL00_05515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NRL00_05520	COG0750	zinc metalloprotease
NRL00_05535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRL00_05540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRL00_05545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRL00_05550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRL00_05555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRL00_05565	COG0825	malonyl-CoA metabolic process
NRL00_05570	COG3710	Transcriptional regulator
NRL00_05575	COG0531	amino acid
NRL00_05580	COG1982	Orn Lys Arg decarboxylase major
NRL00_05585	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRL00_05600	COG0814	amino acid
NRL00_05605	COG0531	amino acid
NRL00_05620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRL00_05630	COG0180	Tryptophanyl-tRNA synthetase
NRL00_05645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRL00_05655	COG1012	belongs to the aldehyde dehydrogenase family
NRL00_05665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRL00_05675	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRL00_05675	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRL00_05675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_05675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRL00_05710	COG0488	(ABC) transporter
NRL00_05720	COG0366	Alpha amylase catalytic
NRL00_05730	COG3097	Belongs to the UPF0267 family
NRL00_05750	COG0471	metal ion transport
NRL00_05750	COG0490	domain, Protein
NRL00_05790	COG0012	GTP binding
NRL00_05795	COG0193	aminoacyl-tRNA hydrolase activity
NRL00_05800	COG0737	Belongs to the 5'-nucleotidase family
NRL00_05805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRL00_05815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NRL00_05820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NRL00_05825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NRL00_05830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRL00_05835	COG2890	protein-(glutamine-N5) methyltransferase activity
NRL00_05845	COG2912	Transglutaminase-like superfamily
NRL00_05850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NRL00_05855	COG1301	dicarboxylic acid transport
NRL00_05865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRL00_05880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRL00_05885	COG1115	amino acid carrier protein
NRL00_05900	COG0714	Associated with various cellular activities
NRL00_05910	COG3104	oligopeptide transport
NRL00_05915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRL00_05920	COG1678	Uncharacterized ACR, COG1678
NRL00_05930	COG0189	ligase activity
NRL00_05935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRL00_05945	COG3091	SprT-like family
NRL00_05955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NRL00_05970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRL00_05975	COG0739	heme binding
NRL00_05980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRL00_05985	COG3408	Glycogen debranching enzyme
NRL00_05985	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NRL00_05995	COG1881	PFAM PEBP family protein
NRL00_06000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRL00_06005	COG0583	DNA-binding transcription factor activity
NRL00_06015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRL00_06025	COG0583	DNA-binding transcription factor activity
NRL00_06030	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_06035	COG0616	signal peptide processing
NRL00_06040	COG3724	N-succinylarginine dihydrolase activity
NRL00_06060	COG0840	transmembrane signaling receptor activity
NRL00_06070	COG2971	BadF BadG BcrA BcrD
NRL00_06080	COG4608	Belongs to the ABC transporter superfamily
NRL00_06085	COG0444	Belongs to the ABC transporter superfamily
NRL00_06090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRL00_06095	COG0601	transmembrane transport
NRL00_06100	COG4166	transmembrane transport
NRL00_06105	COG2205	protein histidine kinase activity
NRL00_06105	COG0784	Response regulator, receiver
NRL00_06145	COG3220	belongs to the UPF0276 family
NRL00_06175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRL00_06180	COG1289	transmembrane transporter activity
NRL00_06185	COG0303	'Molybdopterin
NRL00_06190	COG0746	molybdenum cofactor guanylyltransferase activity
NRL00_06200	COG4662	Binding-protein-dependent transport system inner membrane component
NRL00_06210	COG2204	response regulator
NRL00_06215	COG3852	Histidine kinase
NRL00_06220	COG1910	domain protein
NRL00_06225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRL00_06260	COG3383	formate dehydrogenase (NAD+) activity
NRL00_06260	COG3383	formate dehydrogenase (NAD+) activity
NRL00_06265	COG0437	4 iron, 4 sulfur cluster binding
NRL00_06275	COG0281	malic enzyme
NRL00_06295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_06310	COG2706	6-phosphogluconolactonase activity
NRL00_06320	COG1196	nuclear chromosome segregation
NRL00_06320	COG3264	Mechanosensitive ion channel
NRL00_06325	COG0469	pyruvate kinase activity
NRL00_06340	COG4651	solute:proton antiporter activity
NRL00_06340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRL00_06350	COG2974	May be involved in recombination
NRL00_06360	COG0420	3'-5' exonuclease activity
NRL00_06365	COG0419	ATPase involved in DNA repair
NRL00_06380	COG3038	cytochrome b561
NRL00_06390	COG2190	(PTS) system
NRL00_06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRL00_06400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_06405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRL00_06410	COG0542	response to heat
NRL00_06425	COG2770	Histidine kinase
NRL00_06425	COG3437	response regulator, receiver
NRL00_06430	COG1720	tRNA m6t6A37 methyltransferase activity
NRL00_06450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NRL00_06455	COG4988	ABC transporter
NRL00_06470	COG0745	RESPONSE REGULATOR receiver
NRL00_06480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRL00_06495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NRL00_06500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NRL00_06510	COG0083	homoserine kinase activity
NRL00_06515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRL00_06535	COG0813	purine-nucleoside phosphorylase activity
NRL00_06555	COG2203	Gaf domain
NRL00_06555	COG3706	GGDEF domain
NRL00_06555	COG4251	negative regulation of phosphorylation
NRL00_06555	COG5001	Diguanylate cyclase
NRL00_06560	COG0784	Response regulator, receiver
NRL00_06560	COG2205	protein histidine kinase activity
NRL00_06560	COG5002	protein histidine kinase activity
NRL00_06565	COG3384	dioxygenase
NRL00_06575	COG1283	sodium-dependent phosphate transmembrane transporter activity
NRL00_06585	COG0531	amino acid
NRL00_06595	COG0531	amino acid
NRL00_06615	COG1396	sequence-specific DNA binding
NRL00_06615	COG1917	Cupin 2, conserved barrel domain protein
NRL00_06620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRL00_06640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRL00_06645	COG2375	cellular response to nickel ion
NRL00_06655	COG0577	efflux transmembrane transporter activity
NRL00_06655	COG1136	(ABC) transporter
NRL00_06660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_06670	COG1227	inorganic diphosphatase activity
NRL00_06675	COG0497	DNA recombination
NRL00_06680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRL00_06685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRL00_06690	COG0443	Heat shock 70 kDa protein
NRL00_06695	COG0484	heat shock protein binding
NRL00_06725	COG1285	pathogenesis
NRL00_06740	COG0640	Transcriptional regulator
NRL00_06770	COG0095	Lipoate-protein ligase
NRL00_06785	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRL00_06790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_06815	COG0708	Exodeoxyribonuclease III
NRL00_06830	COG0071	Belongs to the small heat shock protein (HSP20) family
NRL00_06835	COG2211	Major facilitator Superfamily
NRL00_06875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NRL00_06880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRL00_06885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRL00_06890	COG1845	cytochrome c oxidase, subunit III
NRL00_06895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NRL00_06900	COG0109	protoheme IX farnesyltransferase activity
NRL00_06905	COG2814	Major facilitator Superfamily
NRL00_06920	COG3152	Membrane
NRL00_06930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRL00_06950	COG3550	peptidyl-serine autophosphorylation
NRL00_06955	COG1396	sequence-specific DNA binding
NRL00_06960	COG1988	membrane-bound metal-dependent
NRL00_06995	COG0159	tryptophan synthase activity
NRL00_07000	COG0133	tryptophan synthase activity
NRL00_07005	COG0135	phosphoribosylanthranilate isomerase activity
NRL00_07005	COG0134	indole-3-glycerol-phosphate synthase activity
NRL00_07010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRL00_07015	COG0512	Glutamine amidotransferase of anthranilate synthase
NRL00_07015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRL00_07020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRL00_07030	COG0009	L-threonylcarbamoyladenylate synthase
NRL00_07040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRL00_07050	COG1946	Acyl-CoA thioesterase
NRL00_07065	COG1309	transcriptional regulator
NRL00_07070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_07075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRL00_07090	COG1091	dTDP-4-dehydrorhamnose reductase activity
NRL00_07110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRL00_07115	COG2030	dehydratase
NRL00_07125	COG2244	polysaccharide biosynthetic process
NRL00_07145	COG1216	Glycosyl transferase, family 2
NRL00_07150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRL00_07165	COG3132	Protein of unknown function, DUF480
NRL00_07205	COG1278	Cold shock
NRL00_07230	COG4166	transmembrane transport
NRL00_07235	COG0697	spore germination
NRL00_07240	COG1349	DNA-binding transcription factor activity
NRL00_07245	COG1882	Formate acetyltransferase
NRL00_07250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRL00_07255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRL00_07280	COG4166	transmembrane transport
NRL00_07285	COG0622	Phosphoesterase
NRL00_07300	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NRL00_07305	COG0784	Response regulator, receiver
NRL00_07305	COG0835	chemotaxis
NRL00_07310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NRL00_07315	COG1815	bacterial-type flagellum-dependent cell motility
NRL00_07335	COG4787	bacterial-type flagellum-dependent cell motility
NRL00_07345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRL00_07350	COG1706	bacterial-type flagellum-dependent cell motility
NRL00_07355	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRL00_07355	COG3951	Flagellar rod assembly protein muramidase FlgJ
NRL00_07360	COG1256	bacterial-type flagellum assembly
NRL00_07370	COG2239	Acts as a magnesium transporter
NRL00_07380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRL00_07385	COG2716	regulation of RNA biosynthetic process
NRL00_07410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRL00_07415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRL00_07420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRL00_07425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRL00_07445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NRL00_07460	COG0590	tRNA wobble adenosine to inosine editing
NRL00_07465	COG0573	inorganic phosphate transmembrane transporter activity
NRL00_07470	COG0581	inorganic phosphate transmembrane transporter activity
NRL00_07475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRL00_07480	COG0704	Plays a role in the regulation of phosphate uptake
NRL00_07495	COG1253	flavin adenine dinucleotide binding
NRL00_07510	COG0531	amino acid
NRL00_07535	COG0765	amino acid transport
NRL00_07540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_07545	COG2271	Major facilitator Superfamily
NRL00_07560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRL00_07585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRL00_07590	COG0477	Major facilitator Superfamily
NRL00_07595	COG0123	including yeast histone deacetylase and acetoin utilization protein
NRL00_07605	COG1199	ATP-dependent helicase activity
NRL00_07620	COG1448	Aminotransferase
NRL00_07625	COG0433	COG0433 Predicted ATPase
NRL00_07640	COG2333	competence protein COMEC
NRL00_07640	COG0658	competence protein
NRL00_07650	COG1663	tetraacyldisaccharide 4'-kinase activity
NRL00_07655	COG2835	tetraacyldisaccharide 4'-kinase activity
NRL00_07660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NRL00_07665	COG2197	response regulator
NRL00_07670	COG0322	excinuclease ABC activity
NRL00_07715	COG2863	cytochrome
NRL00_07720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRL00_07725	COG0437	4 iron, 4 sulfur cluster binding
NRL00_07730	COG3301	Polysulphide reductase, NrfD
NRL00_07735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRL00_07745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRL00_07765	COG2199	diguanylate cyclase activity
NRL00_07765	COG2203	Gaf domain
NRL00_07810	COG2119	membrane
NRL00_07815	COG0023	Translation Initiation Factor
NRL00_07855	COG2205	protein histidine kinase activity
NRL00_07855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_07865	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NRL00_07870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRL00_07875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRL00_07880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRL00_07885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NRL00_07890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRL00_07900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NRL00_07905	COG0505	Belongs to the CarA family
NRL00_07910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRL00_07915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRL00_07950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRL00_07955	COG0513	Belongs to the DEAD box helicase family
NRL00_07965	COG4104	PAAR repeat-containing protein
NRL00_07980	COG0789	Transcriptional regulator
NRL00_07995	COG0493	'glutamate synthase
NRL00_08000	COG0067	glutamate synthase
NRL00_08000	COG0069	glutamate synthase activity
NRL00_08000	COG0070	glutamate synthase
NRL00_08005	COG1242	4 iron, 4 sulfur cluster binding
NRL00_08065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRL00_08070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRL00_08070	COG0574	Belongs to the PEP-utilizing enzyme family
NRL00_08110	COG1464	Belongs to the NlpA lipoprotein family
NRL00_08115	COG0671	phosphoesterase, PA-phosphatase related
NRL00_08120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRL00_08125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRL00_08135	COG0101	tRNA pseudouridine synthase activity
NRL00_08140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRL00_08145	COG0285	dihydrofolate synthase activity
NRL00_08150	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NRL00_08155	COG2920	part of a sulfur-relay system
NRL00_08160	COG1289	transmembrane transporter activity
NRL00_08165	COG0670	Belongs to the BI1 family
NRL00_08185	COG4792	protein secretion
NRL00_08190	COG4791	protein targeting
NRL00_08195	COG4794	Type iii secretion
NRL00_08200	COG4790	Type iii secretion
NRL00_08270	COG0457	Tetratricopeptide repeat
NRL00_08360	COG1317	bacterial-type flagellum organization
NRL00_08375	COG2194	sulfuric ester hydrolase activity
NRL00_08380	COG0392	lysyltransferase activity
NRL00_08380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRL00_08390	COG0840	transmembrane signaling receptor activity
NRL00_08395	COG5001	Diguanylate cyclase
NRL00_08400	COG0564	pseudouridine synthase activity
NRL00_08415	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NRL00_08425	COG0625	glutathione transferase activity
NRL00_08445	COG0367	asparagine synthase
NRL00_08455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRL00_08455	COG4651	solute:proton antiporter activity
NRL00_08460	COG0647	UMP catabolic process
NRL00_08465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRL00_08470	COG1902	pentaerythritol trinitrate reductase activity
NRL00_08475	COG1253	flavin adenine dinucleotide binding
NRL00_08485	COG0247	lactate metabolic process
NRL00_08485	COG0277	FAD linked oxidase domain protein
NRL00_08495	COG2050	protein possibly involved in aromatic compounds catabolism
NRL00_08505	COG2056	Na+-H+ antiporter family
NRL00_08510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRL00_08525	COG0346	lactoylglutathione lyase activity
NRL00_08530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRL00_08535	COG4660	Part of a membrane complex involved in electron transport
NRL00_08540	COG4659	FMN binding
NRL00_08545	COG4658	electron transport chain
NRL00_08550	COG4656	Part of a membrane complex involved in electron transport
NRL00_08555	COG2878	Part of a membrane complex involved in electron transport
NRL00_08560	COG4657	Part of a membrane complex involved in electron transport
NRL00_08565	COG0697	spore germination
NRL00_08580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRL00_08585	COG1288	antiporter activity
NRL00_08590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRL00_08590	COG3264	Mechanosensitive ion channel
NRL00_08595	COG0436	Aminotransferase
NRL00_08605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NRL00_08610	COG2027	D-alanyl-D-alanine carboxypeptidase
NRL00_08615	COG1061	Type III restriction enzyme res subunit
NRL00_08620	COG1566	PFAM secretion protein HlyD family protein
NRL00_08630	COG1966	Carbon starvation protein
NRL00_08635	COG3279	Response regulator of the LytR AlgR family
NRL00_08640	COG3275	phosphorelay sensor kinase activity
NRL00_08645	COG2199	diguanylate cyclase activity
NRL00_08645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRL00_08650	COG1012	belongs to the aldehyde dehydrogenase family
NRL00_08650	COG1454	alcohol dehydrogenase
NRL00_08660	COG2095	MarC family integral membrane protein
NRL00_08670	COG0601	transmembrane transport
NRL00_08675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRL00_08680	COG0444	Belongs to the ABC transporter superfamily
NRL00_08690	COG0861	Integral membrane protein TerC family
NRL00_08695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRL00_08705	COG1301	dicarboxylic acid transport
NRL00_08720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRL00_08730	COG0840	transmembrane signaling receptor activity
NRL00_08735	COG0537	adenosine 5'-monophosphoramidase activity
NRL00_08770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRL00_08775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRL00_08790	COG2354	Protein conserved in bacteria
NRL00_08805	COG2233	PERMEase
NRL00_08810	COG3150	esterase
NRL00_08815	COG1252	NADH dehydrogenase
NRL00_08835	COG0393	Putative heavy-metal-binding
NRL00_08850	COG1368	sulfuric ester hydrolase activity
NRL00_08860	COG0527	aspartate kinase activity
NRL00_08865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRL00_08865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRL00_08870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRL00_08890	COG0596	Alpha beta hydrolase
NRL00_08895	COG0583	DNA-binding transcription factor activity
NRL00_08900	COG1620	l-lactate permease
NRL00_08905	COG0247	lactate metabolic process
NRL00_08910	COG1139	Iron-sulfur cluster binding protein
NRL00_08950	COG0577	efflux transmembrane transporter activity
NRL00_08955	COG1136	(ABC) transporter
NRL00_08975	COG2814	Major facilitator Superfamily
NRL00_08995	COG0672	)-iron permease
NRL00_09035	COG0659	secondary active sulfate transmembrane transporter activity
NRL00_09045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRL00_09050	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NRL00_09055	COG0437	4 iron, 4 sulfur cluster binding
NRL00_09060	COG5557	Pfam Polysulphide reductase, NrfD
NRL00_09065	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NRL00_09070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRL00_09075	COG1773	rubredoxin
NRL00_09080	COG0747	negative chemotaxis
NRL00_09085	COG0601	transmembrane transport
NRL00_09090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRL00_09095	COG0444	Belongs to the ABC transporter superfamily
NRL00_09100	COG1124	(ABC) transporter
NRL00_09105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NRL00_09115	COG0375	protein maturation
NRL00_09120	COG0309	Hydrogenase expression formation protein (HypE)
NRL00_09130	COG0298	carbon dioxide binding
NRL00_09135	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NRL00_09145	COG1921	L-seryl-tRNASec selenium transferase activity
NRL00_09155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRL00_09165	COG3260	NADH ubiquinone oxidoreductase 20
NRL00_09170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_09175	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NRL00_09175	COG3261	NADH dehydrogenase
NRL00_09180	COG0650	Formate hydrogenlyase subunit 4
NRL00_09185	COG0651	ATP synthesis coupled electron transport
NRL00_09190	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_09195	COG3158	transport of potassium into the cell
NRL00_09205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_09230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRL00_09235	COG0326	Molecular chaperone. Has ATPase activity
NRL00_09240	COG0563	adenylate kinase activity
NRL00_09245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRL00_09250	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NRL00_09255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRL00_09270	COG5001	Diguanylate cyclase
NRL00_09270	COG3300	MHYT domain
NRL00_09275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRL00_09300	COG1021	2,3-dihydroxybenzoate-AMP ligase
NRL00_09305	COG1535	isochorismatase
NRL00_09305	COG3433	isochorismatase activity
NRL00_09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRL00_09315	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_09325	COG3321	synthase
NRL00_09325	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_09325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRL00_09325	COG0300	oxidoreductase activity
NRL00_09325	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_09330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRL00_09340	COG1120	ATPase activity
NRL00_09345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRL00_09350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRL00_09355	COG4771	TonB-dependent receptor
NRL00_09395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRL00_09400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NRL00_09405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRL00_09420	COG1570	exodeoxyribonuclease VII activity
NRL00_09445	COG3158	transport of potassium into the cell
NRL00_09450	COG0516	GMP reductase activity
NRL00_09450	COG0517	IMP dehydrogenase activity
NRL00_09455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRL00_09455	COG0519	Catalyzes the synthesis of GMP from XMP
NRL00_09500	COG2062	phosphohistidine phosphatase, SixA
NRL00_09510	COG0697	spore germination
NRL00_09515	COG4166	transmembrane transport
NRL00_09520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NRL00_09525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRL00_09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRL00_09540	COG1136	(ABC) transporter
NRL00_09545	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRL00_09550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NRL00_09560	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRL00_09565	COG0740	serine-type endopeptidase activity
NRL00_09570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRL00_09575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRL00_09580	COG0776	regulation of translation
NRL00_09585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRL00_09590	COG0488	(ABC) transporter
NRL00_09595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRL00_09600	COG3162	membrane
NRL00_09615	COG1024	Enoyl-CoA hydratase
NRL00_09660	COG1115	amino acid carrier protein
NRL00_09675	COG1584	GPR1 FUN34 yaaH family protein
NRL00_09710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRL00_09715	COG1960	acyl-CoA dehydrogenase activity
NRL00_09725	COG1960	acyl-CoA dehydrogenase activity
NRL00_09730	COG1024	Enoyl-CoA hydratase
NRL00_09735	COG1024	Enoyl-CoA hydratase
NRL00_09745	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_09755	COG0730	response to heat
NRL00_09770	COG1073	alpha beta
NRL00_09775	COG1506	peptidase
NRL00_09775	COG0823	Involved in the tonB-independent uptake of proteins
NRL00_09780	COG0702	epimerase
NRL00_09785	COG0583	DNA-binding transcription factor activity
NRL00_09790	COG0667	Aldo Keto reductase
NRL00_09840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRL00_09850	COG0438	transferase activity, transferring glycosyl groups
NRL00_09920	COG0438	transferase activity, transferring glycosyl groups
NRL00_09925	COG0583	DNA-binding transcription factor activity
NRL00_09930	COG2723	6-phospho-beta-galactosidase activity
NRL00_09935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRL00_09945	COG0583	DNA-binding transcription factor activity
NRL00_09950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRL00_09955	COG0673	inositol 2-dehydrogenase activity
NRL00_09960	COG0583	DNA-binding transcription factor activity
NRL00_09970	COG1560	Kdo2-lipid A biosynthetic process
NRL00_09975	COG1560	Kdo2-lipid A biosynthetic process
NRL00_09990	COG2199	diguanylate cyclase activity
NRL00_09990	COG2203	Gaf domain
NRL00_10000	COG0417	DNA replication proofreading
NRL00_10030	COG0534	Mate efflux family protein
NRL00_10040	COG0307	riboflavin synthase, alpha
NRL00_10050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRL00_10055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NRL00_10060	COG0697	spore germination
NRL00_10065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRL00_10110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRL00_10115	COG3099	Belongs to the UPF0263 family
NRL00_10120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NRL00_10125	COG2894	cell division
NRL00_10130	COG0850	regulation of cytokinetic process
NRL00_10135	COG3100	YcgL domain-containing protein
NRL00_10140	COG2951	lytic endotransglycosylase activity
NRL00_10145	COG1760	l-serine dehydratase
NRL00_10150	COG1760	l-serine dehydratase
NRL00_10155	COG3123	guanosine phosphorylase activity
NRL00_10175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NRL00_10180	COG2067	long-chain fatty acid transport protein
NRL00_10185	COG2067	long-chain fatty acid transport protein
NRL00_10195	COG1595	DNA-templated transcription, initiation
NRL00_10225	COG0714	Associated with various cellular activities
NRL00_10230	COG0183	Belongs to the thiolase family
NRL00_10235	COG1024	Enoyl-CoA hydratase
NRL00_10235	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRL00_10255	COG4383	Mu-like prophage protein gp29
NRL00_10290	COG3829	transcription factor binding
NRL00_10295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRL00_10300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRL00_10305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRL00_10315	COG0549	Belongs to the carbamate kinase family
NRL00_10320	COG0697	spore germination
NRL00_10325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NRL00_10325	COG3608	succinylglutamate desuccinylase aspartoacylase
NRL00_10330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NRL00_10335	COG2068	MobA-Related Protein
NRL00_10340	COG0493	'glutamate synthase
NRL00_10340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_10345	COG0402	S-adenosylhomocysteine deaminase activity
NRL00_10350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRL00_10355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRL00_10355	COG2080	2 iron, 2 sulfur cluster binding
NRL00_10360	COG2233	PERMEase
NRL00_10365	COG0402	S-adenosylhomocysteine deaminase activity
NRL00_10370	COG2252	PERMEase
NRL00_10375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRL00_10380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRL00_10385	COG2080	2 iron, 2 sulfur cluster binding
NRL00_10395	COG3134	Outer membrane lipoprotein
NRL00_10405	COG1288	antiporter activity
NRL00_10410	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_10420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRL00_10420	COG0140	phosphoribosyl-ATP diphosphatase activity
NRL00_10425	COG0107	imidazoleglycerol-phosphate synthase activity
NRL00_10430	COG2198	Histidine kinase
NRL00_10430	COG2205	protein histidine kinase activity
NRL00_10430	COG0784	Response regulator, receiver
NRL00_10435	COG2199	diguanylate cyclase activity
NRL00_10440	COG3437	response regulator, receiver
NRL00_10445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NRL00_10450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NRL00_10455	COG0131	Imidazoleglycerol-phosphate dehydratase
NRL00_10455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRL00_10460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRL00_10465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRL00_10470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NRL00_10480	COG1199	ATP-dependent helicase activity
NRL00_10485	COG1214	PFAM Peptidase M22, glycoprotease
NRL00_10500	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_10505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NRL00_10520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRL00_10525	COG2832	Protein of unknown function (DUF454)
NRL00_10530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRL00_10535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NRL00_10540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRL00_10565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NRL00_10575	COG3314	Sporulation integral membrane protein YlbJ
NRL00_10585	COG0517	IMP dehydrogenase activity
NRL00_10585	COG0617	tRNA 3'-terminal CCA addition
NRL00_10585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRL00_10590	COG1643	Atp-dependent helicase
NRL00_10600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRL00_10610	COG3437	response regulator, receiver
NRL00_10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRL00_10620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NRL00_10625	COG0709	Synthesizes selenophosphate from selenide and ATP
NRL00_10640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRL00_10645	COG0840	transmembrane signaling receptor activity
NRL00_10650	COG1254	Belongs to the acylphosphatase family
NRL00_10655	COG0625	glutathione transferase activity
NRL00_10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRL00_10660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRL00_10665	COG0489	protein tyrosine kinase activity
NRL00_10670	COG0572	uridine kinase
NRL00_10675	COG0717	Belongs to the dCTP deaminase family
NRL00_10680	COG0306	phosphate transporter
NRL00_10685	COG1530	ribonuclease E activity
NRL00_10695	COG0546	phosphoglycolate phosphatase activity
NRL00_10700	COG0424	maF-like protein
NRL00_10705	COG2814	Major facilitator Superfamily
NRL00_10720	COG1399	metal-binding, possibly nucleic acid-binding protein
NRL00_10725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRL00_10730	COG0416	fatty acid biosynthetic process
NRL00_10735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRL00_10745	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_10750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRL00_10760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRL00_10765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRL00_10770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRL00_10775	COG0470	DNA polymerase III
NRL00_10780	COG0084	hydrolase, TatD family'
NRL00_10795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRL00_10795	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NRL00_10800	COG3008	intermembrane lipid transfer
NRL00_10805	COG2995	paraquat-inducible protein a
NRL00_10815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRL00_10820	COG0372	Belongs to the citrate synthase family
NRL00_10865	COG4221	oxidoreductase activity
NRL00_10875	COG3141	response to X-ray
NRL00_10895	COG4128	Pfam Zonular occludens toxin
NRL00_10935	COG1067	ATP-dependent peptidase activity
NRL00_10940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRL00_10955	COG0488	(ABC) transporter
NRL00_10965	COG0116	Belongs to the methyltransferase superfamily
NRL00_10965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRL00_10975	COG0167	dihydroorotate dehydrogenase activity
NRL00_10980	COG2902	Dehydrogenase
NRL00_10990	COG0308	aminopeptidase N
NRL00_11000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NRL00_11005	COG1956	GAF domain-containing protein
NRL00_11015	COG3278	Belongs to the heme-copper respiratory oxidase family
NRL00_11030	COG2010	Cytochrome c
NRL00_11055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRL00_11060	COG0589	response to stress
NRL00_11065	COG0037	tRNA processing
NRL00_11085	COG1869	D-ribose catabolic process
NRL00_11090	COG1129	ABC transporter
NRL00_11095	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRL00_11100	COG1879	ABC-type sugar transport system periplasmic component
NRL00_11105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRL00_11110	COG1609	Transcriptional regulator
NRL00_11115	COG5001	Diguanylate cyclase
NRL00_11115	COG3300	MHYT domain
NRL00_11140	COG0784	Response regulator, receiver
NRL00_11140	COG2205	protein histidine kinase activity
NRL00_11145	COG0776	regulation of translation
NRL00_11150	COG0072	phenylalanine-tRNA ligase activity
NRL00_11150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRL00_11155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRL00_11160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRL00_11165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRL00_11170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRL00_11175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRL00_11200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRL00_11210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRL00_11220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRL00_11225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NRL00_11230	COG3313	Fe-S protein
NRL00_11235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_11235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_11235	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NRL00_11240	COG1105	Belongs to the carbohydrate kinase PfkB family
NRL00_11245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_11245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_11250	COG1609	Transcriptional regulator
NRL00_11255	COG0814	amino acid
NRL00_11270	COG0513	Belongs to the DEAD box helicase family
NRL00_11280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NRL00_11285	COG2890	protein-(glutamine-N5) methyltransferase activity
NRL00_11290	COG2840	Smr protein MutS2
NRL00_11300	COG3706	GGDEF domain
NRL00_11305	COG0406	alpha-ribazole phosphatase activity
NRL00_11330	COG2824	Alkylphosphonate utilization operon protein PhnA
NRL00_11335	COG0384	phenazine biosynthesis protein PhzF
NRL00_11360	COG0242	peptide deformylase activity
NRL00_11385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRL00_11390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRL00_11395	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NRL00_11405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRL00_11410	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NRL00_11420	COG0205	6-phosphofructokinase activity
NRL00_11425	COG1473	amidohydrolase
NRL00_11430	COG1011	Hydrolase
NRL00_11435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRL00_11470	COG3593	DNA synthesis involved in DNA repair
NRL00_11490	COG0583	DNA-binding transcription factor activity
NRL00_11495	COG0730	response to heat
NRL00_11500	COG3148	PFAM DTW domain containing protein
NRL00_11510	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRL00_11520	COG0386	Belongs to the glutathione peroxidase family
NRL00_11525	COG0513	Belongs to the DEAD box helicase family
NRL00_11530	COG0456	acetyltransferase
NRL00_11570	COG2329	Antibiotic biosynthesis monooxygenase
NRL00_11575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRL00_11605	COG2501	S4 domain
NRL00_11620	COG1132	(ABC) transporter
NRL00_11625	COG1132	(ABC) transporter
NRL00_11635	COG3118	belongs to the thioredoxin family
NRL00_11640	COG0471	metal ion transport
NRL00_11645	COG0058	SHG alpha-glucan phosphorylase activity
NRL00_11675	COG0814	amino acid
NRL00_11680	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NRL00_11685	COG0514	ATP-dependent DNA helicase (RecQ)
NRL00_11690	COG2766	serine protein kinase
NRL00_11695	COG2718	Belongs to the UPF0229 family
NRL00_11700	COG2719	SpoVR family
NRL00_11705	COG2186	Transcriptional regulator
NRL00_11710	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRL00_11715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRL00_11720	COG0586	Pfam SNARE associated Golgi protein
NRL00_11730	COG0556	nucleotide-excision repair
NRL00_11740	COG0569	domain protein
NRL00_11740	COG2985	domain, Protein
NRL00_11745	COG1196	nuclear chromosome segregation
NRL00_11745	COG0741	lytic transglycosylase activity
NRL00_11745	COG0739	heme binding
NRL00_11750	COG3181	Tripartite tricarboxylate transporter family receptor
NRL00_11765	COG4565	transcriptional regulatory protein
NRL00_11770	COG3290	protein histidine kinase activity
NRL00_11775	COG1940	carbohydrate kinase activity
NRL00_11775	COG1846	Transcriptional regulator
NRL00_11780	COG0840	transmembrane signaling receptor activity
NRL00_11785	COG3012	SEC-C Motif Domain Protein
NRL00_11790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRL00_11795	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NRL00_11800	COG0247	lactate metabolic process
NRL00_11815	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRL00_11820	COG0437	4 iron, 4 sulfur cluster binding
NRL00_11825	COG3301	Polysulphide reductase, NrfD
NRL00_11830	COG1138	Cytochrome C-type biogenesis protein
NRL00_11835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRL00_11840	COG3088	subunit of a heme lyase
NRL00_11840	COG4235	cytochrome complex assembly
NRL00_11855	COG3033	Beta-eliminating lyase
NRL00_11865	COG3046	protein related to deoxyribodipyrimidine photolyase
NRL00_11870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRL00_11875	COG0516	GMP reductase activity
NRL00_11875	COG0517	IMP dehydrogenase activity
NRL00_11890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRL00_11905	COG4774	siderophore transport
NRL00_11910	COG4977	sequence-specific DNA binding
NRL00_11920	COG0583	DNA-binding transcription factor activity
NRL00_11925	COG2910	NAD(P)H-binding
NRL00_11940	COG0612	Peptidase, M16
NRL00_11945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRL00_11950	COG2076	Multidrug Resistance protein
NRL00_11955	COG1944	ATP diphosphatase activity
NRL00_11960	COG2116	formate transmembrane transporter activity
NRL00_11965	COG1882	Formate acetyltransferase
NRL00_11970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRL00_11975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRL00_11980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRL00_11990	COG1840	ABC-type Fe3 transport system, periplasmic component
NRL00_11995	COG3842	ATPase activity
NRL00_12005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRL00_12010	COG2983	Belongs to the UPF0260 family
NRL00_12015	COG1280	lysine exporter protein (LysE YggA)
NRL00_12040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRL00_12045	COG0045	succinate-CoA ligase (ADP-forming) activity
NRL00_12050	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRL00_12055	COG0567	Dehydrogenase, E1 component
NRL00_12070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NRL00_12095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRL00_12100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NRL00_12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRL00_12110	COG3069	C4-dicarboxylate transmembrane transporter activity
NRL00_12125	COG1451	nucleotide metabolic process
NRL00_12140	COG0254	rRNA binding
NRL00_12145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRL00_12155	COG0583	DNA-binding transcription factor activity
NRL00_12160	COG2925	Exonuclease
NRL00_12170	COG3345	alpha-galactosidase
NRL00_12175	COG1380	Effector of murein hydrolase LrgA
NRL00_12180	COG1346	cytolysis
NRL00_12185	COG0295	cytidine deaminase activity
NRL00_12190	COG1022	Amp-dependent synthetase and ligase
NRL00_12205	COG0861	Integral membrane protein TerC family
NRL00_12210	COG2885	chlorophyll binding
NRL00_12235	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRL00_12245	COG3768	UPF0283 membrane protein
NRL00_12250	COG3106	COG3106 Predicted ATPase
NRL00_12265	COG1842	Phage shock protein A
NRL00_12270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRL00_12280	COG4168	peptide transport system, permease
NRL00_12285	COG4171	peptide transport system, permease
NRL00_12300	COG4172	Belongs to the ABC transporter superfamily
NRL00_12310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NRL00_12315	COG1286	toxin biosynthetic process
NRL00_12320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRL00_12325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRL00_12330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NRL00_12335	COG0531	amino acid
NRL00_12335	COG1674	ftsk spoiiie
NRL00_12345	COG0492	ferredoxin-NADP+ reductase activity
NRL00_12350	COG3706	GGDEF domain
NRL00_12355	COG3134	Outer membrane lipoprotein
NRL00_12360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NRL00_12365	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NRL00_12370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NRL00_12375	COG0542	response to heat
NRL00_12380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NRL00_12385	COG1278	Cold shock
NRL00_12390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRL00_12465	COG3829	transcription factor binding
NRL00_12525	COG3209	COG3209 Rhs family protein
NRL00_12560	COG1435	thymidine kinase activity
NRL00_12565	COG1757	Na H antiporter
NRL00_12570	COG2916	Histone family protein nucleoid-structuring protein H-NS
NRL00_12575	COG2096	Adenosyltransferase
NRL00_12580	COG3530	Putative quorum-sensing-regulated virulence factor
NRL00_12585	COG0602	queuosine metabolic process
NRL00_12590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NRL00_12610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NRL00_12620	COG0776	regulation of translation
NRL00_12625	COG0539	negative regulation of cytoplasmic translation
NRL00_12630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRL00_12635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRL00_12645	COG0583	DNA-binding transcription factor activity
NRL00_12665	COG0778	Nitroreductase
NRL00_12670	COG5001	Diguanylate cyclase
NRL00_12670	COG3300	MHYT domain
NRL00_12680	COG0583	DNA-binding transcription factor activity
NRL00_12685	COG3437	response regulator, receiver
NRL00_12710	COG4989	oxidoreductase activity
NRL00_12715	COG0724	RNA recognition motif
NRL00_12735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NRL00_12755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRL00_12760	COG1360	Flagellar Motor Protein
NRL00_12765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_12770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_12775	COG0649	NAD binding
NRL00_12775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_12790	COG1034	ATP synthesis coupled electron transport
NRL00_12795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRL00_12800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_12805	COG0839	Belongs to the complex I subunit 6 family
NRL00_12810	COG0713	ATP synthesis coupled electron transport
NRL00_12820	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRL00_12825	COG1007	ATP synthesis coupled electron transport
NRL00_12840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRL00_12840	COG2199	diguanylate cyclase activity
NRL00_12845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRL00_12845	COG0047	phosphoribosylformylglycinamidine synthase activity
NRL00_12850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRL00_12855	COG1645	bacterial-type flagellum-dependent swarming motility
NRL00_12860	COG1160	GTP binding
NRL00_12865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRL00_12870	COG2976	Protein conserved in bacteria
NRL00_12875	COG0124	histidyl-tRNA synthetase
NRL00_12880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NRL00_12895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NRL00_12900	COG0105	UTP biosynthetic process
NRL00_12905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRL00_12915	COG0633	Ferredoxin
NRL00_12920	COG0443	Heat shock 70 kDa protein
NRL00_12925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRL00_12935	COG0822	iron-sulfur transferase activity
NRL00_12940	COG1104	cysteine desulfurase activity
NRL00_12960	COG3154	lipid carrier protein
NRL00_12965	COG0826	peptidase U32
NRL00_12970	COG0826	peptidase U32
NRL00_12985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRL00_12990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRL00_12995	COG1862	Preprotein translocase
NRL00_13000	COG0343	queuine tRNA-ribosyltransferase activity
NRL00_13005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NRL00_13010	COG0517	IMP dehydrogenase activity
NRL00_13020	COG3634	alkyl hydroperoxide reductase activity
NRL00_13025	COG0477	Major facilitator Superfamily
NRL00_13030	COG3852	Histidine kinase
NRL00_13045	COG3119	arylsulfatase activity
NRL00_13050	COG0641	radical SAM
NRL00_13055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRL00_13055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRL00_13060	COG0509	glycine decarboxylation via glycine cleavage system
NRL00_13065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRL00_13070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRL00_13075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRL00_13095	COG2814	Major facilitator Superfamily
NRL00_13100	COG0625	glutathione transferase activity
NRL00_13110	COG0483	inositol monophosphate 1-phosphatase activity
NRL00_13130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRL00_13190	COG0301	tRNA thio-modification
NRL00_13190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRL00_13200	COG4953	penicillin-binding protein 1C
NRL00_13205	COG2373	Large extracellular alpha-helical protein
NRL00_13210	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRL00_13220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRL00_13240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_13250	COG2431	L-lysine efflux transmembrane transporter activity
NRL00_13255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRL00_13260	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NRL00_13280	COG1393	Belongs to the ArsC family
NRL00_13290	COG4783	chaperone-mediated protein folding
NRL00_13295	COG0425	Belongs to the sulfur carrier protein TusA family
NRL00_13310	COG0596	Alpha beta hydrolase
NRL00_13320	COG3842	ATPase activity
NRL00_13325	COG3833	ABC-type maltose transport systems, permease component
NRL00_13330	COG1175	transmembrane transport
NRL00_13340	COG3081	Nucleoid-associated protein
NRL00_13345	COG3082	Protein of unknown function (DUF1414)
NRL00_13350	COG3083	sulfuric ester hydrolase activity
NRL00_13355	COG4771	TonB-dependent receptor
NRL00_13360	COG1770	oligopeptidase
NRL00_13380	COG4574	serine-type endopeptidase inhibitor activity
NRL00_13385	COG3085	chromosome segregation
NRL00_13390	COG0583	DNA-binding transcription factor activity
NRL00_13395	COG0287	Prephenate dehydrogenase
NRL00_13395	COG1605	Chorismate mutase
NRL00_13400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRL00_13405	COG0584	glycerophosphoryl diester phosphodiesterase
NRL00_13420	COG1349	DNA-binding transcription factor activity
NRL00_13425	COG2271	Major facilitator Superfamily
NRL00_13430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRL00_13435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRL00_13450	COG0583	DNA-binding transcription factor activity
NRL00_13475	COG0656	L-ascorbic acid biosynthetic process
NRL00_13480	COG2814	Major facilitator Superfamily
NRL00_13495	COG3220	belongs to the UPF0276 family
NRL00_13515	COG1294	oxidase, subunit
NRL00_13525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRL00_13540	COG2979	Protein of unknown function (DUF533)
NRL00_13570	COG2271	Major facilitator Superfamily
NRL00_13575	COG0583	DNA-binding transcription factor activity
NRL00_13585	COG2807	transmembrane transport
NRL00_13595	COG1187	pseudouridine synthase activity
NRL00_13610	COG1403	HNH endonuclease
NRL00_13620	COG2964	Protein conserved in bacteria
NRL00_13625	COG3681	Belongs to the UPF0597 family
NRL00_13635	COG0814	amino acid
NRL00_13655	COG0583	DNA-binding transcription factor activity
NRL00_13660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NRL00_13670	COG1166	arginine decarboxylase activity
NRL00_13680	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRL00_13710	COG0583	DNA-binding transcription factor activity
NRL00_13720	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NRL00_13725	COG0840	transmembrane signaling receptor activity
NRL00_13730	COG0302	gtp cyclohydrolase
NRL00_13740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRL00_13765	COG2267	carboxylic ester hydrolase activity
NRL00_13770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NRL00_13785	COG0314	molybdopterin synthase activity
NRL00_13790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NRL00_13795	COG0315	cyclic pyranopterin monophosphate synthase activity
NRL00_13800	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRL00_13805	COG3005	denitrification pathway
NRL00_13815	COG0348	domain, Protein
NRL00_13820	COG0437	4 iron, 4 sulfur cluster binding
NRL00_13825	COG0243	molybdopterin cofactor binding
NRL00_13835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_13835	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRL00_13840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRL00_13845	COG3850	Histidine kinase
NRL00_13850	COG2197	response regulator
NRL00_13860	COG2205	protein histidine kinase activity
NRL00_13860	COG0784	Response regulator, receiver
NRL00_13880	COG0121	glutamine amidotransferase
NRL00_13885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRL00_13890	COG1960	acyl-CoA dehydrogenase activity
NRL00_13895	COG0784	Response regulator, receiver
NRL00_13895	COG3437	response regulator, receiver
NRL00_13905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRL00_13910	COG0328	RNA-DNA hybrid ribonuclease activity
NRL00_13915	COG2226	methyltransferase
NRL00_13920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRL00_13925	COG1388	LysM domain
NRL00_13925	COG0741	lytic transglycosylase activity
NRL00_13930	COG3021	interspecies interaction between organisms
NRL00_13940	COG1607	acyl-coa hydrolase
NRL00_13955	COG0741	lytic transglycosylase activity
NRL00_13965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRL00_13985	COG2911	Protein conserved in bacteria
NRL00_13990	COG0729	surface antigen
NRL00_14000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRL00_14005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRL00_14015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRL00_14025	COG4134	Bacterial extracellular solute-binding protein
NRL00_14035	COG4136	ATPase activity
NRL00_14040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRL00_14045	COG2951	lytic endotransglycosylase activity
NRL00_14060	COG1846	Transcriptional regulator
NRL00_14070	COG0033	Phosphoglucomutase
NRL00_14075	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NRL00_14080	COG0596	Alpha beta hydrolase
NRL00_14095	COG0716	FMN binding
NRL00_14105	COG0735	belongs to the Fur family
NRL00_14110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRL00_14120	COG1263	PTS System
NRL00_14120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRL00_14120	COG2190	(PTS) system
NRL00_14125	COG0363	glucosamine-6-phosphate deaminase activity
NRL00_14130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRL00_14135	COG1846	Transcriptional regulator
NRL00_14135	COG1940	carbohydrate kinase activity
NRL00_14145	COG2194	sulfuric ester hydrolase activity
NRL00_14150	COG0217	transcriptional regulatory protein
NRL00_14155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRL00_14160	COG1801	Protein of unknown function DUF72
NRL00_14165	COG4106	trans-aconitate 2-methyltransferase activity
NRL00_14170	COG0500	methyltransferase
NRL00_14190	COG0450	alkyl hydroperoxide reductase
NRL00_14195	COG0583	DNA-binding transcription factor activity
NRL00_14205	COG0791	NLP P60 protein
NRL00_14220	COG1309	transcriptional regulator
NRL00_14260	COG0534	Mate efflux family protein
NRL00_14270	COG2841	Protein conserved in bacteria
NRL00_14275	COG2169	Transcriptional regulator
NRL00_14275	COG1917	Cupin 2, conserved barrel domain protein
NRL00_14280	COG2366	antibiotic biosynthetic process
NRL00_14285	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRL00_14285	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRL00_14285	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRL00_14285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NRL00_14295	COG0633	Ferredoxin
NRL00_14295	COG3217	Mosc domain protein beta barrel domain protein
NRL00_14295	COG0633	Ferredoxin
NRL00_14295	COG3217	Mosc domain protein beta barrel domain protein
NRL00_14305	COG0501	Belongs to the peptidase M48B family
NRL00_14310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NRL00_14315	COG1073	alpha beta
NRL00_14315	COG2226	methyltransferase
NRL00_14320	COG0156	8-amino-7-oxononanoate synthase activity
NRL00_14325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRL00_14345	COG0017	Asparaginyl-tRNA synthetase
NRL00_14350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRL00_14365	COG3069	C4-dicarboxylate transmembrane transporter activity
NRL00_14375	COG0583	DNA-binding transcription factor activity
NRL00_14390	COG1393	Belongs to the ArsC family
NRL00_14395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRL00_14400	COG1876	peptidase activity
NRL00_14410	COG3263	regulation of cellular component size
NRL00_14430	COG1280	lysine exporter protein (LysE YggA)
NRL00_14460	COG0564	pseudouridine synthase activity
NRL00_14470	COG1454	alcohol dehydrogenase
NRL00_14475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRL00_14480	COG0702	epimerase
NRL00_14485	COG2914	Belongs to the UPF0125 (RnfH) family
NRL00_14490	COG2867	negative regulation of translational initiation
NRL00_14495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRL00_14525	COG0583	DNA-binding transcription factor activity
NRL00_14530	COG3048	D-serine ammonia-lyase activity
NRL00_14540	COG0659	secondary active sulfate transmembrane transporter activity
NRL00_14545	COG0538	isocitrate dehydrogenase activity
NRL00_14550	COG2207	Transcriptional regulator
NRL00_14570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_14580	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRL00_14580	COG1902	pentaerythritol trinitrate reductase activity
NRL00_14585	COG0789	Transcriptional regulator
NRL00_14595	COG0456	acetyltransferase
NRL00_14625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_14625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_14625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_14635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_14635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_14635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRL00_14645	COG1187	pseudouridine synthase activity
NRL00_14655	COG0482	sulfurtransferase activity
NRL00_14660	COG2915	High frequency lysogenization protein hflD homolog
NRL00_14665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRL00_14670	COG2850	peptidyl-arginine hydroxylation
NRL00_14685	COG3153	acetyltransferase
NRL00_14700	COG0259	pyridoxamine-phosphate oxidase activity
NRL00_14715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRL00_14715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRL00_14720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NRL00_14735	COG0457	Tetratricopeptide repeat
NRL00_14740	COG4235	cytochrome complex assembly
NRL00_14740	COG3088	subunit of a heme lyase
NRL00_14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRL00_14750	COG1138	Cytochrome C-type biogenesis protein
NRL00_14755	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NRL00_14760	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRL00_14765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRL00_14770	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRL00_14785	COG0835	chemotaxis
NRL00_14795	COG1192	Involved in chromosome partitioning
NRL00_14805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRL00_14810	COG2201	protein-glutamate methylesterase activity
NRL00_14815	COG0643	Histidine kinase
NRL00_14815	COG0784	Response regulator, receiver
NRL00_14815	COG2198	Histidine kinase
NRL00_14820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NRL00_14845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRL00_14855	COG1684	flagellar biosynthetic protein fliR
NRL00_14910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRL00_14920	COG1677	Flagellar hook-basal body complex protein FliE
NRL00_14935	COG1393	Belongs to the ArsC family
NRL00_14940	COG0798	PFAM Bile acid sodium symporter
NRL00_14955	COG0640	Transcriptional regulator
NRL00_14960	COG1342	Belongs to the UPF0251 family
NRL00_14975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRL00_14995	COG1737	Transcriptional regulator
NRL00_15000	COG0469	pyruvate kinase activity
NRL00_15015	COG1960	acyl-CoA dehydrogenase activity
NRL00_15025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRL00_15035	COG0243	molybdopterin cofactor binding
NRL00_15040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRL00_15045	COG0583	DNA-binding transcription factor activity
NRL00_15055	COG1376	ErfK ybiS ycfS ynhG family protein
NRL00_15055	COG1388	LysM domain
NRL00_15070	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NRL00_15075	COG0791	NLP P60 protein
NRL00_15085	COG3118	belongs to the thioredoxin family
NRL00_15095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRL00_15100	COG0788	formyltetrahydrofolate deformylase activity
NRL00_15110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRL00_15130	COG0366	Alpha amylase catalytic
NRL00_15135	COG0739	heme binding
NRL00_15135	COG1196	nuclear chromosome segregation
NRL00_15135	COG0741	lytic transglycosylase activity
NRL00_15140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRL00_15145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRL00_15150	COG0673	inositol 2-dehydrogenase activity
NRL00_15175	COG3152	Membrane
NRL00_15200	COG1032	radical SAM domain protein
NRL00_15210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRL00_15215	COG1566	PFAM secretion protein HlyD family protein
NRL00_15225	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRL00_15230	COG0733	neurotransmitter:sodium symporter activity
NRL00_15260	COG0281	malic enzyme
NRL00_15265	COG2207	Transcriptional regulator
NRL00_15270	COG0534	Mate efflux family protein
NRL00_15285	COG2233	PERMEase
NRL00_15290	COG0095	Lipoate-protein ligase
NRL00_15295	COG1115	amino acid carrier protein
NRL00_15300	COG0019	diaminopimelate decarboxylase activity
NRL00_15310	COG0678	peroxiredoxin activity
NRL00_15320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRL00_15330	COG1126	abc transporter atp-binding protein
NRL00_15335	COG0765	amino acid transport
NRL00_15340	COG4597	amino acid ABC transporter
NRL00_15345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_15360	COG1131	(ABC) transporter
NRL00_15365	COG0545	Peptidyl-prolyl cis-trans isomerase
NRL00_15395	COG5002	protein histidine kinase activity
NRL00_15400	COG0745	RESPONSE REGULATOR receiver
NRL00_15405	COG0346	lactoylglutathione lyase activity
NRL00_15410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRL00_15415	COG1960	acyl-CoA dehydrogenase activity
NRL00_15420	COG3284	Transcriptional regulator
NRL00_15435	COG0697	spore germination
NRL00_15440	COG4565	transcriptional regulatory protein
NRL00_15445	COG3290	protein histidine kinase activity
NRL00_15450	COG0281	malic enzyme
NRL00_15465	COG1846	Transcriptional regulator
NRL00_15470	COG1566	PFAM secretion protein HlyD family protein
NRL00_15500	COG0602	queuosine metabolic process
NRL00_15505	COG1328	CTP reductase activity
NRL00_15515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRL00_15520	COG3115	cell septum assembly
NRL00_15525	COG1196	nuclear chromosome segregation
NRL00_15535	COG2860	membrane
NRL00_15545	COG3108	Peptidase M15
NRL00_15550	COG2989	Protein conserved in bacteria
NRL00_15565	COG0463	Glycosyl transferase, family 2
NRL00_15580	COG0366	Alpha amylase catalytic
NRL00_15615	COG3706	GGDEF domain
NRL00_15625	COG3590	peptidase
NRL00_15645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NRL00_15655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NRL00_15660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRL00_15690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NRL00_15695	COG0583	DNA-binding transcription factor activity
NRL00_15715	COG0583	DNA-binding transcription factor activity
NRL00_15730	COG0739	heme binding
NRL00_15740	COG1511	domain protein
NRL00_15740	COG3264	Mechanosensitive ion channel
NRL00_15745	COG0584	glycerophosphoryl diester phosphodiesterase
NRL00_15755	COG1053	succinate dehydrogenase
NRL00_15760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRL00_15765	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NRL00_15790	COG3214	Protein conserved in bacteria
NRL00_15795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRL00_15830	COG0642	Histidine kinase
NRL00_15850	COG0516	GMP reductase activity
NRL00_15860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRL00_15865	COG3647	Membrane
NRL00_15875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRL00_15895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRL00_15910	COG3706	GGDEF domain
NRL00_15920	COG1335	isochorismatase
NRL00_15925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRL00_15930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRL00_15935	COG1702	phosphate starvation-inducible protein PhoH
NRL00_15940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRL00_15945	COG4535	Mg2 and Co2 transporter CorC
NRL00_15950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NRL00_15955	COG2888	peptidyl-tyrosine sulfation
NRL00_15960	COG0495	leucyl-tRNA aminoacylation
NRL00_15975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRL00_15980	COG0799	negative regulation of ribosome biogenesis
NRL00_15985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NRL00_15990	COG0768	penicillin binding
NRL00_15995	COG0772	Belongs to the SEDS family
NRL00_16000	COG2951	lytic endotransglycosylase activity
NRL00_16010	COG1686	Belongs to the peptidase S11 family
NRL00_16015	COG2921	Belongs to the UPF0250 family
NRL00_16020	COG0321	lipoyl(octanoyl) transferase activity
NRL00_16025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NRL00_16030	COG3545	Serine hydrolase
NRL00_16050	COG0789	Transcriptional regulator
NRL00_16055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NRL00_16065	COG1970	mechanosensitive ion channel activity
NRL00_16075	COG4974	Belongs to the 'phage' integrase family
NRL00_16085	COG0312	modulator of DNA gyrase
NRL00_16090	COG0312	modulator of DNA gyrase
NRL00_16160	COG0114	fumarate hydratase activity
NRL00_16170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NRL00_16175	COG3706	GGDEF domain
NRL00_16180	COG2211	Major facilitator Superfamily
NRL00_16185	COG1185	polyribonucleotide nucleotidyltransferase activity
NRL00_16190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRL00_16195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRL00_16200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRL00_16205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NRL00_16210	COG0195	Participates in both transcription termination and antitermination
NRL00_16215	COG0779	Required for maturation of 30S ribosomal subunits
NRL00_16230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRL00_16235	COG0149	triose-phosphate isomerase activity
NRL00_16240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRL00_16245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRL00_16255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NRL00_16260	COG1534	Rna-binding protein
NRL00_16275	COG1360	Flagellar Motor Protein
NRL00_16280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRL00_16285	COG1722	exodeoxyribonuclease VII activity
NRL00_16290	COG0142	geranyltranstransferase activity
NRL00_16295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRL00_16300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRL00_16305	COG0601	transmembrane transport
NRL00_16315	COG4172	Belongs to the ABC transporter superfamily
NRL00_16320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRL00_16325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NRL00_16330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRL00_16335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NRL00_16350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRL00_16350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRL00_16355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NRL00_16370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRL00_16380	COG0784	Response regulator, receiver
NRL00_16380	COG2198	Histidine kinase
NRL00_16380	COG2205	protein histidine kinase activity
NRL00_16385	COG1879	ABC-type sugar transport system periplasmic component
NRL00_16395	COG0745	RESPONSE REGULATOR receiver
NRL00_16400	COG3005	denitrification pathway
NRL00_16410	COG3381	protein complex oligomerization
NRL00_16430	COG3300	MHYT domain
NRL00_16430	COG5001	Diguanylate cyclase
NRL00_16440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRL00_16445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NRL00_16450	COG0511	ligase activity, forming carbon-carbon bonds
NRL00_16455	COG0439	Biotin carboxylase
NRL00_16460	COG3924	membrane
NRL00_16465	COG4145	pantothenate transmembrane transporter activity
NRL00_16470	COG1263	PTS System
NRL00_16470	COG2190	(PTS) system
NRL00_16470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRL00_16475	COG0583	DNA-binding transcription factor activity
NRL00_16480	COG0604	alcohol dehydrogenase
NRL00_16485	COG2264	protein methyltransferase activity
NRL00_16500	COG0778	Nitroreductase
NRL00_16505	COG1902	pentaerythritol trinitrate reductase activity
NRL00_16505	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRL00_16510	COG0616	signal peptide processing
NRL00_16530	COG3139	Protein of unknown function (DUF1315)
NRL00_16535	COG0252	asparaginase activity
NRL00_16540	COG0786	glutamate:sodium symporter activity
NRL00_16555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRL00_16560	COG0384	phenazine biosynthesis protein PhzF
NRL00_16565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRL00_16570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRL00_16575	COG0175	sulfate reduction
NRL00_16580	COG2113	Glycine betaine
NRL00_16585	COG4176	ABC-type proline glycine betaine transport system permease component
NRL00_16590	COG4175	Glycine betaine
NRL00_16600	COG3610	response to peptide
NRL00_16605	COG2966	Psort location CytoplasmicMembrane, score
NRL00_16615	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRL00_16625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRL00_16630	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_16640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRL00_16665	COG2986	histidine ammonia-lyase
NRL00_16690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRL00_16695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRL00_16730	COG1858	cytochrome C peroxidase
NRL00_16740	COG2313	pseudouridylate synthase activity
NRL00_16745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRL00_16790	COG1073	alpha beta
NRL00_16795	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NRL00_16800	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRL00_16805	COG4608	Belongs to the ABC transporter superfamily
NRL00_16810	COG0444	Belongs to the ABC transporter superfamily
NRL00_16820	COG4239	(ABC) transporter, permease
NRL00_16825	COG4174	ABC transporter (Permease)
NRL00_16840	COG0811	peptide transport
NRL00_16845	COG0811	peptide transport
NRL00_16850	COG0848	biopolymer transport protein
NRL00_16900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRL00_16905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRL00_16910	COG0840	transmembrane signaling receptor activity
NRL00_16920	COG1278	Cold shock
NRL00_16940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NRL00_16945	COG1162	GTPase activity
NRL00_16950	COG0688	phosphatidylethanolamine metabolic process
NRL00_16955	COG4628	conserved protein (DUF2132)
NRL00_16975	COG5001	Diguanylate cyclase
NRL00_16975	COG3300	MHYT domain
NRL00_16980	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRL00_17010	COG1132	(ABC) transporter
NRL00_17020	COG1404	Belongs to the peptidase S8 family
NRL00_17025	COG2897	thiosulfate sulfurtransferase activity
NRL00_17030	COG2066	Belongs to the glutaminase family
NRL00_17035	COG3171	Protein conserved in bacteria
NRL00_17040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRL00_17045	COG4935	Belongs to the peptidase S8 family
NRL00_17045	COG2234	aminopeptidase activity
NRL00_17050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRL00_17055	COG2200	EAL domain
NRL00_17060	COG1090	epimerase
NRL00_17065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NRL00_17070	COG4181	ATPase activity
NRL00_17075	COG2755	lipolytic protein G-D-S-L family
NRL00_17080	COG0835	chemotaxis
NRL00_17080	COG0784	Response regulator, receiver
NRL00_17100	COG0569	domain protein
NRL00_17100	COG2985	domain, Protein
NRL00_17105	COG1272	protein, Hemolysin III
NRL00_17110	COG0076	glutamate decarboxylase activity
NRL00_17115	COG2917	probably involved in intracellular septation
NRL00_17120	COG2350	Protein conserved in bacteria
NRL00_17130	COG1555	photosystem II stabilization
NRL00_17135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRL00_17140	COG3104	oligopeptide transport
NRL00_17145	COG0745	RESPONSE REGULATOR receiver
NRL00_17175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRL00_17190	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NRL00_17220	COG0316	Belongs to the HesB IscA family
NRL00_17230	COG0038	chloride channel
NRL00_17235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NRL00_17250	COG0671	phosphoesterase, PA-phosphatase related
NRL00_17260	COG0784	Response regulator, receiver
NRL00_17260	COG3437	response regulator, receiver
NRL00_17270	COG2076	Multidrug Resistance protein
NRL00_17280	COG0346	lactoylglutathione lyase activity
NRL00_17285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRL00_17290	COG1643	Atp-dependent helicase
NRL00_17300	COG1489	DNA binding
NRL00_17305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRL00_17310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRL00_17325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NRL00_17330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NRL00_17360	COG1924	4 iron, 4 sulfur cluster binding
NRL00_17365	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NRL00_17370	COG0842	Transport permease protein
NRL00_17375	COG1131	(ABC) transporter
NRL00_17390	COG0163	prenyltransferase activity
NRL00_17395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRL00_17400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NRL00_17415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NRL00_17430	COG1136	(ABC) transporter
NRL00_17450	COG0840	transmembrane signaling receptor activity
NRL00_17475	COG0529	Catalyzes the synthesis of activated sulfate
NRL00_17480	COG0471	metal ion transport
NRL00_17480	COG3273	potassium ion transport
NRL00_17485	COG2895	sulfate adenylyltransferase (ATP) activity
NRL00_17490	COG0175	sulfate reduction
NRL00_17495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRL00_17495	COG1648	precorrin-2 dehydrogenase activity
NRL00_17500	COG0330	HflC and HflK could
NRL00_17505	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRL00_17510	COG0517	IMP dehydrogenase activity
NRL00_17510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRL00_17515	COG0488	(ABC) transporter
NRL00_17525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NRL00_17550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRL00_17560	COG0668	transmembrane transport
NRL00_17570	COG2731	YhcH YjgK YiaL family protein
NRL00_17585	COG1794	racemase activity, acting on amino acids and derivatives
NRL00_17600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRL00_17625	COG0733	neurotransmitter:sodium symporter activity
NRL00_17635	COG0733	neurotransmitter:sodium symporter activity
NRL00_17650	COG0561	phosphatase activity
NRL00_17680	COG1846	Transcriptional regulator
NRL00_17685	COG2130	NADP-dependent
NRL00_17690	COG1051	belongs to the nudix hydrolase family
NRL00_17710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NRL00_17715	COG1640	4-alpha-glucanotransferase
NRL00_17720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRL00_17725	COG0676	glucose-6-phosphate 1-epimerase activity
NRL00_17730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NRL00_17735	COG0840	transmembrane signaling receptor activity
NRL00_17810	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NRL00_17815	COG2885	chlorophyll binding
NRL00_17820	COG0823	Involved in the tonB-independent uptake of proteins
NRL00_17835	COG0811	peptide transport
NRL00_17840	COG0824	Thioesterase
NRL00_17845	COG3790	cyd operon protein YbgE
NRL00_17850	COG4890	Cyd operon protein YbgT
NRL00_17855	COG1294	oxidase, subunit
NRL00_17860	COG1271	oxidase subunit
NRL00_17865	COG2255	four-way junction helicase activity
NRL00_17870	COG0632	four-way junction helicase activity
NRL00_17875	COG0840	transmembrane signaling receptor activity
NRL00_17880	COG0442	prolyl-tRNA aminoacylation
NRL00_17885	COG4221	oxidoreductase activity
NRL00_17900	COG1024	Enoyl-CoA hydratase
NRL00_17910	COG0110	maltose O-acetyltransferase activity
NRL00_17920	COG4166	transmembrane transport
NRL00_17935	COG1872	DUF167
NRL00_17940	COG0762	integral membrane protein
NRL00_17945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRL00_17950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRL00_17965	COG3022	response to hydroperoxide
NRL00_17970	COG0513	Belongs to the DEAD box helicase family
NRL00_17975	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRL00_18000	COG0735	belongs to the Fur family
NRL00_18005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRL00_18020	COG0776	regulation of translation
NRL00_18055	COG0560	Phosphoserine phosphatase
NRL00_18065	COG5002	protein histidine kinase activity
NRL00_18065	COG5001	Diguanylate cyclase
NRL00_18065	COG3447	MASE1 domain protein
NRL00_18070	COG0813	purine-nucleoside phosphorylase activity
NRL00_18075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRL00_18080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRL00_18085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRL00_18095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRL00_18100	COG0084	hydrolase, TatD family'
NRL00_18105	COG2165	general secretion pathway protein
NRL00_18120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRL00_18125	COG0004	ammonium transporteR
NRL00_18140	COG0795	lipopolysaccharide-transporting ATPase activity
NRL00_18145	COG0795	lipopolysaccharide-transporting ATPase activity
NRL00_18150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRL00_18155	COG2927	DNA polymerase III (CHI subunit)
NRL00_18160	COG0525	valine-tRNA ligase activity
NRL00_18165	COG1253	flavin adenine dinucleotide binding
NRL00_18170	COG0586	Pfam SNARE associated Golgi protein
NRL00_18175	COG1686	Belongs to the peptidase S11 family
NRL00_18210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NRL00_18215	COG0527	aspartate kinase activity
NRL00_18220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRL00_18230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRL00_18235	COG1546	Belongs to the CinA family
NRL00_18240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NRL00_18260	COG3068	Protein conserved in bacteria
NRL00_18270	COG0739	heme binding
NRL00_18290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NRL00_18295	COG1121	(ABC) transporter
NRL00_18300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRL00_18305	COG0583	DNA-binding transcription factor activity
NRL00_18310	COG0697	spore germination
NRL00_18315	COG1573	uracil-dna glycosylase
NRL00_18320	COG2962	Rard protein
NRL00_18330	COG2827	Endonuclease containing a URI domain
NRL00_18345	COG1842	Phage shock protein A
NRL00_18350	COG0204	Acyl-transferase
NRL00_18370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRL00_18420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRL00_18430	COG0583	DNA-binding transcription factor activity
NRL00_18455	COG1289	transmembrane transporter activity
NRL00_18460	COG1566	PFAM secretion protein HlyD family protein
NRL00_18475	COG1051	belongs to the nudix hydrolase family
NRL00_18480	COG3150	esterase
NRL00_18490	COG3151	Protein conserved in bacteria
NRL00_18495	COG0494	nUDIX hydrolase
NRL00_18500	COG1538	Outer membrane efflux protein
NRL00_18505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NRL00_18505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRL00_18510	COG1560	Kdo2-lipid A biosynthetic process
NRL00_18525	COG1392	Phosphate transport regulator
NRL00_18530	COG0306	phosphate transporter
NRL00_18535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRL00_18565	COG0583	DNA-binding transcription factor activity
NRL00_18570	COG1380	Effector of murein hydrolase LrgA
NRL00_18575	COG1346	cytolysis
NRL00_18590	COG0617	tRNA 3'-terminal CCA addition
NRL00_18595	COG3409	Peptidoglycan-binding domain 1 protein
NRL00_18595	COG3267	Type II secretory pathway component ExeA
NRL00_18605	COG1194	a g-specific adenine glycosylase
NRL00_18610	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NRL00_18620	COG3111	PFAM Bacterial OB fold (BOF) protein
NRL00_18625	COG3240	lipase activity
NRL00_18640	COG3009	Protein conserved in bacteria
NRL00_18645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRL00_18645	COG3008	intermembrane lipid transfer
NRL00_18650	COG2995	paraquat-inducible protein a
NRL00_18660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRL00_18670	COG4251	negative regulation of phosphorylation
NRL00_18670	COG3706	GGDEF domain
NRL00_18670	COG2203	Gaf domain
NRL00_18670	COG5001	Diguanylate cyclase
NRL00_18675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRL00_18680	COG2813	Specifically methylates the guanine in position
NRL00_18685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRL00_18690	COG0297	glycogen (starch) synthase activity
NRL00_18730	COG1757	Na H antiporter
NRL00_18735	COG0583	DNA-binding transcription factor activity
NRL00_18740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NRL00_18745	COG3842	ATPase activity
NRL00_18750	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRL00_18755	COG1177	transmembrane transport
NRL00_18760	COG1012	belongs to the aldehyde dehydrogenase family
NRL00_18785	COG0110	maltose O-acetyltransferase activity
NRL00_18790	COG0366	Alpha amylase catalytic
NRL00_18795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRL00_18795	COG1263	PTS System
NRL00_18800	COG1609	Transcriptional regulator
NRL00_18815	COG0252	asparaginase activity
NRL00_18830	COG1803	Methylglyoxal synthase
NRL00_18855	COG1444	tRNA N-acetyltransferase activity
NRL00_18865	COG0784	Response regulator, receiver
NRL00_18865	COG0835	chemotaxis
NRL00_18870	COG3314	Sporulation integral membrane protein YlbJ
NRL00_18905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NRL00_18910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRL00_18925	COG0477	Major facilitator Superfamily
NRL00_18930	COG0523	cobalamin synthesis protein
NRL00_18940	COG1280	lysine exporter protein (LysE YggA)
NRL00_18950	COG1049	propionate catabolic process, 2-methylcitrate cycle
NRL00_18955	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRL00_18960	COG0840	transmembrane signaling receptor activity
NRL00_18965	COG0840	transmembrane signaling receptor activity
NRL00_18975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRL00_18980	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRL00_18985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRL00_18990	COG2186	Transcriptional regulator
NRL00_19015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRL00_19020	COG1459	type II secretion system
NRL00_19035	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NRL00_19040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NRL00_19045	COG0494	nUDIX hydrolase
NRL00_19055	COG0653	protein targeting
NRL00_19065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NRL00_19070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NRL00_19075	COG0849	cell division
NRL00_19080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRL00_19085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRL00_19090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRL00_19095	COG0772	Belongs to the SEDS family
NRL00_19100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRL00_19105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRL00_19110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRL00_19120	COG0768	penicillin binding
NRL00_19125	COG3116	cell division
NRL00_19130	COG0275	rRNA processing
NRL00_19135	COG2001	Belongs to the MraZ family
NRL00_19145	COG1388	LysM domain
NRL00_19145	COG0741	lytic transglycosylase activity
NRL00_19150	COG1360	Flagellar Motor Protein
NRL00_19155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRL00_19160	COG1191	sigma factor activity
NRL00_19185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NRL00_19190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRL00_19195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRL00_19210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRL00_19215	COG1256	bacterial-type flagellum assembly
NRL00_19215	COG4786	Flagellar basal body rod
NRL00_19225	COG1706	bacterial-type flagellum-dependent cell motility
NRL00_19230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRL00_19235	COG4786	Flagellar basal body rod
NRL00_19245	COG1749	Flagellar hook protein flgE
NRL00_19260	COG1815	bacterial-type flagellum-dependent cell motility
NRL00_19295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRL00_19305	COG1677	Flagellar hook-basal body complex protein FliE
NRL00_19355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRL00_19360	COG3107	peptidoglycan biosynthetic process
NRL00_19365	COG0792	nuclease activity
NRL00_19370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRL00_19375	COG2823	Periplasmic or secreted lipoprotein
NRL00_19380	COG2969	positive regulation of protein catabolic process
NRL00_19385	COG0625	glutathione transferase activity
NRL00_19390	COG2857	Cytochrome c1
NRL00_19395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRL00_19400	COG0723	plastoquinol--plastocyanin reductase activity
NRL00_19405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRL00_19410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NRL00_19415	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NRL00_19425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRL00_19430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRL00_19460	COG3964	amidohydrolase
NRL00_19475	COG3711	transcriptional antiterminator
NRL00_19475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_19480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_19485	COG1660	Displays ATPase and GTPase activities
NRL00_19490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRL00_19500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NRL00_19505	COG1137	ATPase activity
NRL00_19510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NRL00_19515	COG3117	lipopolysaccharide transmembrane transporter activity
NRL00_19520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NRL00_19525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRL00_19525	COG0517	IMP dehydrogenase activity
NRL00_19530	COG1127	ABC transporter
NRL00_19535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NRL00_19540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRL00_19545	COG2854	intermembrane phospholipid transfer
NRL00_19555	COG5007	Belongs to the BolA IbaG family
NRL00_19560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRL00_19565	COG0312	modulator of DNA gyrase
NRL00_19570	COG3028	Belongs to the UPF0307 family
NRL00_19580	COG2926	Belongs to the UPF0265 family
NRL00_19610	COG1396	sequence-specific DNA binding
NRL00_19615	COG3135	benzoate transporter
NRL00_19640	COG0840	transmembrane signaling receptor activity
NRL00_19655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRL00_19660	COG2197	response regulator
NRL00_19695	COG4771	TonB-dependent receptor
NRL00_19700	COG2203	Gaf domain
NRL00_19700	COG4251	negative regulation of phosphorylation
NRL00_19700	COG3706	GGDEF domain
NRL00_19700	COG5001	Diguanylate cyclase
NRL00_19745	COG0346	lactoylglutathione lyase activity
NRL00_19755	COG0583	DNA-binding transcription factor activity
NRL00_19765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRL00_19770	COG1074	ATP-dependent DNA helicase activity
NRL00_19775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NRL00_19780	COG2259	Doxx family
NRL00_19785	COG1741	Belongs to the pirin family
NRL00_19795	COG0583	DNA-binding transcription factor activity
NRL00_19820	COG1175	transmembrane transport
NRL00_19830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRL00_19840	COG3706	GGDEF domain
NRL00_19860	COG1247	-acetyltransferase
NRL00_19885	COG0671	phosphoesterase, PA-phosphatase related
NRL00_19890	COG0628	permease
NRL00_19895	COG4221	oxidoreductase activity
NRL00_19900	COG2957	Belongs to the agmatine deiminase family
NRL00_19905	COG0583	DNA-binding transcription factor activity
NRL00_19910	COG3284	Transcriptional regulator
NRL00_19925	COG1461	Dihydroxyacetone kinase
NRL00_19930	COG2376	Dihydroxyacetone kinase
NRL00_19935	COG2252	PERMEase
NRL00_19975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRL00_19980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRL00_19985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRL00_19990	COG0049	tRNA binding
NRL00_19995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRL00_20000	COG2168	tRNA wobble position uridine thiolation
NRL00_20015	COG0251	oxidation-reduction process
NRL00_20020	COG2964	Protein conserved in bacteria
NRL00_20025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRL00_20030	COG0085	RNA polymerase activity
NRL00_20035	COG0222	ribosome binding
NRL00_20040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRL00_20045	COG0081	regulation of translation
NRL00_20050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRL00_20055	COG0250	Participates in transcription elongation, termination and antitermination
NRL00_20070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRL00_20095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRL00_20105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRL00_20125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRL00_20130	COG3005	denitrification pathway
NRL00_20135	COG0243	molybdopterin cofactor binding
NRL00_20165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NRL00_20180	COG2204	response regulator
NRL00_20190	COG2205	protein histidine kinase activity
NRL00_20205	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_20215	COG5413	integral membrane protein
NRL00_20225	COG1522	sequence-specific DNA binding
NRL00_20230	COG2502	aspartate--ammonia ligase
NRL00_20235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRL00_20240	COG0542	response to heat
NRL00_20250	COG0564	pseudouridine synthase activity
NRL00_20255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRL00_20260	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRL00_20270	COG3681	Belongs to the UPF0597 family
NRL00_20280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NRL00_20285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NRL00_20290	COG1979	alcohol dehydrogenase
NRL00_20295	COG2207	Transcriptional regulator
NRL00_20300	COG3040	lipid binding
NRL00_20315	COG0688	phosphatidylethanolamine metabolic process
NRL00_20335	COG0540	Belongs to the ATCase OTCase family
NRL00_20340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NRL00_20345	COG1438	arginine binding
NRL00_20350	COG1288	antiporter activity
NRL00_20355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRL00_20385	COG0840	transmembrane signaling receptor activity
NRL00_20405	COG3250	beta-galactosidase activity
NRL00_20410	COG1609	Transcriptional regulator
NRL00_20415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRL00_20425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRL00_20430	COG2017	converts alpha-aldose to the beta-anomer
NRL00_20435	COG0667	Aldo Keto reductase
NRL00_20440	COG1968	undecaprenyl-diphosphatase activity
NRL00_20445	COG3806	Anti-sigma factor
NRL00_20450	COG1595	DNA-templated transcription, initiation
NRL00_20470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NRL00_20475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NRL00_20480	COG0477	Major facilitator Superfamily
NRL00_20490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRL00_20505	COG2116	formate transmembrane transporter activity
NRL00_20510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRL00_20510	COG1648	precorrin-2 dehydrogenase activity
NRL00_20515	COG2239	Acts as a magnesium transporter
NRL00_20525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRL00_20530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NRL00_20540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NRL00_20550	COG0514	ATP-dependent DNA helicase (RecQ)
NRL00_20555	COG2050	protein possibly involved in aromatic compounds catabolism
NRL00_20570	COG2258	MOSC domain
NRL00_20575	COG1177	transmembrane transport
NRL00_20580	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRL00_20585	COG3842	ATPase activity
NRL00_20605	COG0174	glutamine synthetase
NRL00_20625	COG3045	CreA protein
NRL00_20630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRL00_20635	COG0443	Heat shock 70 kDa protein
NRL00_20640	COG3187	Heat shock protein
NRL00_20650	COG0366	Alpha amylase catalytic
NRL00_20655	COG1086	Polysaccharide biosynthesis protein
NRL00_20660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRL00_20665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NRL00_20675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRL00_20700	COG0367	asparagine synthase
NRL00_20730	COG1215	transferase activity, transferring glycosyl groups
NRL00_20745	COG0318	PFAM AMP-dependent synthetase and ligase
NRL00_20750	COG1028	Short-chain dehydrogenase reductase Sdr
NRL00_20765	COG1083	cytidylyl-transferase
NRL00_20775	COG2089	acid synthase
NRL00_20795	COG4310	Domain of unknown function (DUF2172)
NRL00_20830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRL00_20835	COG0745	RESPONSE REGULATOR receiver
NRL00_20840	COG2205	protein histidine kinase activity
NRL00_20850	COG0281	malic enzyme
NRL00_20855	COG0702	epimerase
NRL00_20860	COG0254	rRNA binding
NRL00_20865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRL00_20895	COG0129	dihydroxy-acid dehydratase activity
NRL00_20905	COG3978	acetolactate synthase activity
NRL00_20965	COG2129	metallophosphoesterase
NRL00_21035	COG0204	Acyl-transferase
NRL00_21040	COG0204	Acyl-transferase
NRL00_21045	COG1683	Conserved Protein
NRL00_21055	COG1335	isochorismatase
NRL00_21065	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NRL00_21070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NRL00_21075	COG3639	organic phosphonate transmembrane transporter activity
NRL00_21080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRL00_21085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRL00_21095	COG3084	Protein conserved in bacteria
NRL00_21100	COG2203	Gaf domain
NRL00_21100	COG3706	GGDEF domain
NRL00_21100	COG4251	negative regulation of phosphorylation
NRL00_21100	COG5001	Diguanylate cyclase
NRL00_21105	COG0789	Transcriptional regulator
NRL00_21115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRL00_21120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NRL00_21125	COG1561	YicC-like family, N-terminal region
NRL00_21140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRL00_21150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRL00_21160	COG2375	cellular response to nickel ion
NRL00_21160	COG1132	(ABC) transporter
NRL00_21165	COG1132	(ABC) transporter
NRL00_21170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRL00_21175	COG4605	iron ion homeostasis
NRL00_21180	COG4604	ABC transporter, ATP-binding protein
NRL00_21185	COG4607	ABC-type enterochelin transport system periplasmic component
NRL00_21190	COG4774	siderophore transport
NRL00_21210	COG3306	glycosyltransferase involved in LPS biosynthesis
NRL00_21225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRL00_21240	COG1063	alcohol dehydrogenase
NRL00_21245	COG3245	cytochrome
NRL00_21250	COG5001	Diguanylate cyclase
NRL00_21250	COG3300	MHYT domain
NRL00_21260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRL00_21265	COG2166	iron-sulfur cluster assembly
NRL00_21270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NRL00_21300	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NRL00_21305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRL00_21310	COG1739	Uncharacterized protein family UPF0029
NRL00_21315	COG0006	proline dipeptidase activity
NRL00_21320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRL00_21325	COG1024	Enoyl-CoA hydratase
NRL00_21325	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRL00_21330	COG0183	Belongs to the thiolase family
NRL00_21355	COG0425	Belongs to the sulfur carrier protein TusA family
NRL00_21360	COG0251	oxidation-reduction process
NRL00_21375	COG2885	chlorophyll binding
NRL00_21385	COG2818	Glycosylase
NRL00_21390	COG0752	glycyl-tRNA synthetase alpha subunit
NRL00_21395	COG0751	glycine-tRNA ligase activity
NRL00_21430	COG0814	amino acid
NRL00_21435	COG0348	domain, Protein
NRL00_21445	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRL00_21450	COG1773	rubredoxin
NRL00_21450	COG0426	domain, Protein
NRL00_21455	COG3604	Transcriptional regulator
NRL00_21460	COG2188	Transcriptional regulator
NRL00_21475	COG1609	Transcriptional regulator
NRL00_21515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRL00_21540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRL00_21555	COG3118	belongs to the thioredoxin family
NRL00_21560	COG0513	Belongs to the DEAD box helicase family
NRL00_21565	COG0248	Ppx GppA phosphatase
NRL00_21580	COG0742	ribosomal rna small subunit methyltransferase
NRL00_21585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRL00_21605	COG0084	hydrolase, TatD family'
NRL00_21610	COG0805	protein transport
NRL00_21615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRL00_21625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NRL00_21630	COG3165	ubiquinone biosynthetic process from chorismate
NRL00_21640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRL00_21645	COG0402	S-adenosylhomocysteine deaminase activity
NRL00_21690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NRL00_21695	COG0848	biopolymer transport protein
NRL00_21700	COG0811	peptide transport
NRL00_21705	COG0811	peptide transport
NRL00_21715	COG2771	luxR family
NRL00_21720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRL00_21725	COG1349	DNA-binding transcription factor activity
NRL00_21730	COG0745	RESPONSE REGULATOR receiver
NRL00_21735	COG2205	protein histidine kinase activity
NRL00_21745	COG4452	Inner membrane protein CreD
NRL00_21750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NRL00_21755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NRL00_21760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRL00_21765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRL00_21770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRL00_21775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRL00_21780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRL00_21790	COG0356	it plays a direct role in the translocation of protons across the membrane
NRL00_21800	COG1475	DNA binding
NRL00_21805	COG1192	Involved in chromosome partitioning
NRL00_21810	COG0357	Ribosomal RNA small subunit methyltransferase G
NRL00_21815	COG0445	tRNA wobble uridine modification
NRL00_21820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRL00_21825	COG4774	siderophore transport
NRL00_21830	COG4615	Cyclic peptide transporter
NRL00_21835	COG1120	ATPase activity
NRL00_21855	COG3645	SOS response
NRL00_21865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NRL00_21870	COG1715	Restriction endonuclease
NRL00_21900	COG0582	viral genome integration into host DNA
NRL00_21905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRL00_21910	COG0706	membrane insertase activity
NRL00_21915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRL00_21920	COG0594	ribonuclease P activity
NRL00_21925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NRL00_21930	COG1126	abc transporter atp-binding protein