locus-tag	class	description
NHF51_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NHF51_00010	COG0592	DNA-directed DNA polymerase activity
NHF51_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NHF51_00020	COG0187	DNA topoisomerase II activity
NHF51_00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NHF51_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
NHF51_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
NHF51_00055	COG3977	Valine--pyruvate aminotransferase
NHF51_00070	COG2814	Major facilitator Superfamily
NHF51_00075	COG0745	RESPONSE REGULATOR receiver
NHF51_00080	COG2205	protein histidine kinase activity
NHF51_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHF51_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_00105	COG4191	Histidine kinase
NHF51_00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHF51_00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHF51_00120	COG1309	transcriptional regulator
NHF51_00150	COG0561	phosphatase activity
NHF51_00155	COG2267	carboxylic ester hydrolase activity
NHF51_00160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHF51_00165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NHF51_00170	COG1758	RNA polymerase activity
NHF51_00175	COG0194	GDP metabolic process
NHF51_00180	COG0859	PFAM glycosyl transferase family 9
NHF51_00185	COG3642	lipopolysaccharide core region biosynthetic process
NHF51_00225	COG0589	response to stress
NHF51_00230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NHF51_00235	COG3706	GGDEF domain
NHF51_00240	COG1528	Iron-storage protein
NHF51_00245	COG2081	HI0933 family
NHF51_00250	COG2223	nitrite transmembrane transporter activity
NHF51_00260	COG3275	phosphorelay sensor kinase activity
NHF51_00265	COG3279	Response regulator of the LytR AlgR family
NHF51_00270	COG2223	nitrite transmembrane transporter activity
NHF51_00275	COG4206	TonB-dependent receptor
NHF51_00280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NHF51_00315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NHF51_00320	COG2166	iron-sulfur cluster assembly
NHF51_00325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NHF51_00330	COG0210	DNA helicase
NHF51_00345	COG1063	alcohol dehydrogenase
NHF51_00355	COG1309	transcriptional regulator
NHF51_00360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NHF51_00395	COG0604	alcohol dehydrogenase
NHF51_00410	COG1580	Controls the rotational direction of flagella during chemotaxis
NHF51_00415	COG3161	chorismate lyase activity
NHF51_00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NHF51_00425	COG2937	Belongs to the GPAT DAPAT family
NHF51_00430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NHF51_00445	COG0534	Mate efflux family protein
NHF51_00450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NHF51_00455	COG2205	protein histidine kinase activity
NHF51_00460	COG0745	RESPONSE REGULATOR receiver
NHF51_00470	COG1045	serine acetyltransferase
NHF51_00480	COG3074	FtsZ-dependent cytokinesis
NHF51_00485	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NHF51_00490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHF51_00490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHF51_00495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NHF51_00535	COG1609	Transcriptional regulator
NHF51_00545	COG3250	beta-galactosidase activity
NHF51_00550	COG2731	YhcH YjgK YiaL family protein
NHF51_00555	COG0531	amino acid
NHF51_00560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHF51_00565	COG0531	amino acid
NHF51_00570	COG0385	Bile acid
NHF51_00575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NHF51_00600	COG0583	DNA-binding transcription factor activity
NHF51_00605	COG1079	Belongs to the binding-protein-dependent transport system permease family
NHF51_00610	COG4603	Belongs to the binding-protein-dependent transport system permease family
NHF51_00615	COG3845	ABC transporter
NHF51_00620	COG1744	ABC transporter substrate-binding protein PnrA-like
NHF51_00625	COG0210	DNA helicase
NHF51_00635	COG2856	Zn peptidase
NHF51_00660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHF51_00695	COG0583	DNA-binding transcription factor activity
NHF51_00700	COG1280	lysine exporter protein (LysE YggA)
NHF51_00705	COG2391	methyltransferase activity
NHF51_00710	COG1280	lysine exporter protein (LysE YggA)
NHF51_00720	COG2962	Rard protein
NHF51_00730	COG1012	belongs to the aldehyde dehydrogenase family
NHF51_00735	COG1396	sequence-specific DNA binding
NHF51_00740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHF51_00750	COG0519	Catalyzes the synthesis of GMP from XMP
NHF51_00750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NHF51_00755	COG0583	DNA-binding transcription factor activity
NHF51_00760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHF51_00770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_00770	COG2221	Nitrite and sulphite reductase 4Fe-4S
NHF51_00780	COG1322	Protein conserved in bacteria
NHF51_00785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHF51_00790	COG0569	domain protein
NHF51_00795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHF51_00795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHF51_00800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NHF51_00805	COG0242	peptide deformylase activity
NHF51_00815	COG0758	DNA mediated transformation
NHF51_00820	COG2922	Belongs to the Smg family
NHF51_00825	COG0551	DNA topoisomerase type I activity
NHF51_00835	COG0009	L-threonylcarbamoyladenylate synthase
NHF51_00840	COG0408	coproporphyrinogen oxidase activity
NHF51_00845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NHF51_00850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NHF51_00860	COG3078	GTPase activator activity
NHF51_00870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NHF51_00875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NHF51_00880	COG2204	response regulator
NHF51_00885	COG3852	Histidine kinase
NHF51_00895	COG0174	glutamine synthetase
NHF51_00900	COG1217	gtp-binding protein TYPA
NHF51_00905	COG1295	ribonuclease BN
NHF51_00910	COG1490	D-aminoacyl-tRNA deacylase activity
NHF51_00920	COG0456	acetyltransferase
NHF51_00930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NHF51_00935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHF51_00940	COG2610	gluconate transmembrane transporter activity
NHF51_00945	COG3265	gluconokinase activity
NHF51_00950	COG0129	dihydroxy-acid dehydratase activity
NHF51_00955	COG0800	Aldolase
NHF51_00960	COG1609	Transcriptional regulator
NHF51_00970	COG4942	peptidase
NHF51_00975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NHF51_00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHF51_00985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NHF51_00990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NHF51_00995	COG0316	Belongs to the HesB IscA family
NHF51_00995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NHF51_01000	COG1040	competence protein
NHF51_01005	COG0596	Alpha beta hydrolase
NHF51_01020	COG2183	response to ionizing radiation
NHF51_01025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NHF51_01045	COG0051	transcription antitermination factor activity, RNA binding
NHF51_01050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NHF51_01055	COG0088	Forms part of the polypeptide exit tunnel
NHF51_01060	COG0089	rRNA binding
NHF51_01065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NHF51_01070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NHF51_01075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NHF51_01080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NHF51_01085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NHF51_01090	COG0255	Belongs to the universal ribosomal protein uL29 family
NHF51_01095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NHF51_01100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NHF51_01105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NHF51_01110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NHF51_01115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NHF51_01120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NHF51_01125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NHF51_01130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NHF51_01135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NHF51_01140	COG1841	ribosomal large subunit assembly
NHF51_01145	COG0200	Binds to the 23S rRNA
NHF51_01150	COG0201	protein transport
NHF51_01155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NHF51_01160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NHF51_01165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NHF51_01170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NHF51_01175	COG0202	RNA polymerase activity
NHF51_01180	COG0203	ribosomal protein L17
NHF51_01235	COG2249	NAD(P)H dehydrogenase (quinone) activity
NHF51_01250	COG1770	oligopeptidase
NHF51_01270	COG3714	YhhN family
NHF51_01295	COG1301	dicarboxylic acid transport
NHF51_01305	COG2095	MarC family integral membrane protein
NHF51_01315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHF51_01325	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NHF51_01335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHF51_01360	COG0742	ribosomal rna small subunit methyltransferase
NHF51_01365	COG0552	protein localization to endoplasmic reticulum
NHF51_01370	COG2884	Cell division ATP-binding protein ftsE
NHF51_01375	COG2177	Part of the ABC transporter FtsEX involved in
NHF51_01385	COG0288	reversible hydration of carbon dioxide
NHF51_01390	COG2188	Transcriptional regulator
NHF51_01395	COG1228	amidohydrolase
NHF51_01400	COG0010	Belongs to the arginase family
NHF51_01405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NHF51_01410	COG2986	histidine ammonia-lyase
NHF51_01415	COG0387	Pfam Sodium calcium exchanger
NHF51_01420	COG2200	EAL domain
NHF51_01425	COG2200	EAL domain
NHF51_01425	COG2199	diguanylate cyclase activity
NHF51_01470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHF51_01475	COG1459	type II secretion system
NHF51_01495	COG4968	Prepilin-type N-terminal cleavage methylation domain
NHF51_01520	COG1077	Cell shape determining protein MreB Mrl
NHF51_01525	COG1792	Involved in formation and maintenance of cell shape
NHF51_01530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NHF51_01535	COG0424	maF-like protein
NHF51_01540	COG1530	ribonuclease E activity
NHF51_01545	COG3164	Protein of unknown function
NHF51_01560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NHF51_01565	COG0312	modulator of DNA gyrase
NHF51_01580	COG0477	Major facilitator Superfamily
NHF51_01590	COG2321	neutral zinc metallopeptidase
NHF51_01630	COG0189	ligase activity
NHF51_01640	COG0745	RESPONSE REGULATOR receiver
NHF51_01660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NHF51_01665	COG0352	thiamine-phosphate diphosphorylase activity
NHF51_01670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHF51_01680	COG2022	thiamine diphosphate biosynthetic process
NHF51_01685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NHF51_01690	COG0583	DNA-binding transcription factor activity
NHF51_01695	COG1280	lysine exporter protein (LysE YggA)
NHF51_01715	COG3932	Exopolysaccharide synthesis, ExoD
NHF51_01745	COG1247	-acetyltransferase
NHF51_01750	COG2226	methyltransferase
NHF51_01760	COG1494	fructose-1,6-bisphosphatase
NHF51_01770	COG3071	HemY protein
NHF51_01775	COG2959	enzyme of heme biosynthesis
NHF51_01780	COG1587	Uroporphyrinogen-III synthase
NHF51_01785	COG0181	hydroxymethylbilane synthase activity
NHF51_01790	COG3072	Adenylate cyclase
NHF51_01795	COG0400	carboxylic ester hydrolase activity
NHF51_01800	COG1965	Belongs to the frataxin family
NHF51_01810	COG0019	diaminopimelate decarboxylase activity
NHF51_01815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NHF51_01830	COG1011	Hydrolase
NHF51_01840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NHF51_01845	COG0561	phosphatase activity
NHF51_01860	COG0842	Transport permease protein
NHF51_01860	COG1129	ABC transporter
NHF51_01870	COG1988	membrane-bound metal-dependent
NHF51_01875	COG1546	Belongs to the CinA family
NHF51_01875	COG1058	Belongs to the CinA family
NHF51_01885	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NHF51_01895	COG1522	sequence-specific DNA binding
NHF51_01900	COG1368	sulfuric ester hydrolase activity
NHF51_01915	COG1285	pathogenesis
NHF51_01940	COG4221	oxidoreductase activity
NHF51_01955	COG1979	alcohol dehydrogenase
NHF51_01965	COG2873	o-acetylhomoserine
NHF51_01990	COG5380	lipid catabolic process
NHF51_01995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NHF51_02010	COG2949	membrane
NHF51_02015	COG0318	PFAM AMP-dependent synthetase and ligase
NHF51_02025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NHF51_02030	COG0596	Alpha beta hydrolase
NHF51_02035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NHF51_02040	COG1169	isochorismate synthase
NHF51_02045	COG1575	Belongs to the MenA family. Type 1 subfamily
NHF51_02050	COG1966	Carbon starvation protein
NHF51_02055	COG2879	small protein
NHF51_02060	COG0523	cobalamin synthesis protein
NHF51_02090	COG0513	Belongs to the DEAD box helicase family
NHF51_02095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHF51_02105	COG1671	Belongs to the UPF0178 family
NHF51_02135	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NHF51_02150	COG2771	luxR family
NHF51_02165	COG1560	Kdo2-lipid A biosynthetic process
NHF51_02170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NHF51_02170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NHF51_02175	COG1538	Outer membrane efflux protein
NHF51_02180	COG0494	nUDIX hydrolase
NHF51_02185	COG3151	Protein conserved in bacteria
NHF51_02195	COG3150	esterase
NHF51_02200	COG1051	belongs to the nudix hydrolase family
NHF51_02215	COG1566	PFAM secretion protein HlyD family protein
NHF51_02220	COG1289	transmembrane transporter activity
NHF51_02285	COG0484	heat shock protein binding
NHF51_02295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHF51_02315	COG0204	Acyl-transferase
NHF51_02320	COG1842	Phage shock protein A
NHF51_02335	COG2827	Endonuclease containing a URI domain
NHF51_02340	COG2962	Rard protein
NHF51_02345	COG1573	uracil-dna glycosylase
NHF51_02355	COG0583	DNA-binding transcription factor activity
NHF51_02360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NHF51_02365	COG1121	(ABC) transporter
NHF51_02370	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NHF51_02390	COG0739	heme binding
NHF51_02420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NHF51_02430	COG1546	Belongs to the CinA family
NHF51_02435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NHF51_02445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHF51_02450	COG0527	aspartate kinase activity
NHF51_02455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NHF51_02490	COG1686	Belongs to the peptidase S11 family
NHF51_02495	COG0586	Pfam SNARE associated Golgi protein
NHF51_02500	COG1253	flavin adenine dinucleotide binding
NHF51_02515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHF51_02520	COG0795	lipopolysaccharide-transporting ATPase activity
NHF51_02525	COG0795	lipopolysaccharide-transporting ATPase activity
NHF51_02540	COG0004	ammonium transporteR
NHF51_02545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHF51_02560	COG0084	hydrolase, TatD family'
NHF51_02565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHF51_02575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NHF51_02580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NHF51_02585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NHF51_02590	COG0813	purine-nucleoside phosphorylase activity
NHF51_02600	COG3064	Membrane
NHF51_02615	COG0560	Phosphoserine phosphatase
NHF51_02640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NHF51_02645	COG0776	regulation of translation
NHF51_02660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHF51_02665	COG0735	belongs to the Fur family
NHF51_02685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NHF51_02690	COG0513	Belongs to the DEAD box helicase family
NHF51_02695	COG3022	response to hydroperoxide
NHF51_02710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NHF51_02715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHF51_02720	COG0762	integral membrane protein
NHF51_02725	COG1872	DUF167
NHF51_02745	COG3112	Uncharacterised protein family (UPF0231)
NHF51_02755	COG3835	regulator
NHF51_02760	COG2610	gluconate transmembrane transporter activity
NHF51_02765	COG1929	Belongs to the glycerate kinase type-1 family
NHF51_02780	COG0583	DNA-binding transcription factor activity
NHF51_02785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHF51_02800	COG0347	Belongs to the P(II) protein family
NHF51_02805	COG1840	ABC-type Fe3 transport system, periplasmic component
NHF51_02815	COG3842	ATPase activity
NHF51_02820	COG2837	iron assimilation
NHF51_02825	COG1438	arginine binding
NHF51_02830	COG1126	abc transporter atp-binding protein
NHF51_02835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_02840	COG4215	(ABC) transporter
NHF51_02845	COG4160	amino acid transport
NHF51_02850	COG0039	L-malate dehydrogenase activity
NHF51_02855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NHF51_02860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHF51_02860	COG1017	nitric oxide dioxygenase activity
NHF51_02870	COG4536	flavin adenine dinucleotide binding
NHF51_02875	COG4137	Cytochrome C assembly protein
NHF51_02880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NHF51_02885	COG0228	four-way junction DNA binding
NHF51_02890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NHF51_02895	COG0336	Belongs to the RNA methyltransferase TrmD family
NHF51_02900	COG0335	large ribosomal subunit rRNA binding
NHF51_02910	COG3066	DNA modification
NHF51_02915	COG1051	belongs to the nudix hydrolase family
NHF51_02925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NHF51_02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NHF51_02935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NHF51_02945	COG0583	DNA-binding transcription factor activity
NHF51_02950	COG0640	Transcriptional regulator
NHF51_02955	COG0268	Binds directly to 16S ribosomal RNA
NHF51_02960	COG0728	peptidoglycan biosynthetic process
NHF51_02965	COG0196	riboflavin kinase activity
NHF51_02970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NHF51_02975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NHF51_02980	COG1047	Peptidyl-prolyl cis-trans
NHF51_02985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NHF51_03025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NHF51_03025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NHF51_03040	COG1854	S-ribosylhomocysteine lyase activity
NHF51_03045	COG3706	GGDEF domain
NHF51_03050	COG0557	exoribonuclease II activity
NHF51_03055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHF51_03065	COG2153	protein acetylation
NHF51_03080	COG1914	H( )-stimulated, divalent metal cation uptake system
NHF51_03085	COG0360	Binds together with S18 to 16S ribosomal RNA
NHF51_03090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NHF51_03095	COG0359	binds to the 23S rRNA
NHF51_03100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHF51_03120	COG0604	alcohol dehydrogenase
NHF51_03120	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_03120	COG3321	synthase
NHF51_03125	COG1238	metal cluster binding
NHF51_03130	COG0612	Peptidase, M16
NHF51_03135	COG2918	glutathione biosynthetic process
NHF51_03140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NHF51_03145	COG1027	Aspartate ammonia-lyase
NHF51_03150	COG3030	protein affecting phage T7 exclusion by the F plasmid
NHF51_03155	COG0534	Mate efflux family protein
NHF51_03160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NHF51_03165	COG0459	protein refolding
NHF51_03185	COG0564	pseudouridine synthase activity
NHF51_03190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHF51_03220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NHF51_03230	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NHF51_03235	COG4208	sulfate ABC transporter
NHF51_03240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NHF51_03245	COG0583	DNA-binding transcription factor activity
NHF51_03250	COG3397	chitin binding
NHF51_03275	COG1328	CTP reductase activity
NHF51_03280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHF51_03295	COG1448	Aminotransferase
NHF51_03305	COG1230	cation diffusion facilitator family transporter
NHF51_03330	COG0513	Belongs to the DEAD box helicase family
NHF51_03355	COG4166	transmembrane transport
NHF51_03365	COG0110	maltose O-acetyltransferase activity
NHF51_03375	COG1024	Enoyl-CoA hydratase
NHF51_03390	COG4221	oxidoreductase activity
NHF51_03400	COG0442	prolyl-tRNA aminoacylation
NHF51_03405	COG0632	four-way junction helicase activity
NHF51_03410	COG2255	four-way junction helicase activity
NHF51_03415	COG1271	oxidase subunit
NHF51_03420	COG1294	oxidase, subunit
NHF51_03425	COG4890	Cyd operon protein YbgT
NHF51_03430	COG3790	cyd operon protein YbgE
NHF51_03435	COG0824	Thioesterase
NHF51_03440	COG0811	peptide transport
NHF51_03455	COG0823	Involved in the tonB-independent uptake of proteins
NHF51_03460	COG2885	chlorophyll binding
NHF51_03465	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NHF51_03540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NHF51_03545	COG0676	glucose-6-phosphate 1-epimerase activity
NHF51_03550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NHF51_03555	COG1640	4-alpha-glucanotransferase
NHF51_03560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NHF51_03585	COG2130	NADP-dependent
NHF51_03590	COG1846	Transcriptional regulator
NHF51_03605	COG1522	sequence-specific DNA binding
NHF51_03620	COG0561	phosphatase activity
NHF51_03635	COG0733	neurotransmitter:sodium symporter activity
NHF51_03640	COG0733	neurotransmitter:sodium symporter activity
NHF51_03650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHF51_03665	COG1794	racemase activity, acting on amino acids and derivatives
NHF51_03670	COG1022	Amp-dependent synthetase and ligase
NHF51_03680	COG0456	acetyltransferase
NHF51_03695	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NHF51_03700	COG5001	Diguanylate cyclase
NHF51_03700	COG3300	MHYT domain
NHF51_03715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NHF51_03720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NHF51_03725	COG0456	acetyltransferase
NHF51_03730	COG1902	pentaerythritol trinitrate reductase activity
NHF51_03745	COG2852	Protein conserved in bacteria
NHF51_03755	COG2957	Belongs to the agmatine deiminase family
NHF51_03775	COG0471	metal ion transport
NHF51_03780	COG0513	Belongs to the DEAD box helicase family
NHF51_03785	COG2203	Gaf domain
NHF51_03785	COG2199	diguanylate cyclase activity
NHF51_03795	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
NHF51_03845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NHF51_03850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHF51_03860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHF51_03890	COG0745	RESPONSE REGULATOR receiver
NHF51_03895	COG3104	oligopeptide transport
NHF51_03900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NHF51_03905	COG1555	photosystem II stabilization
NHF51_03915	COG2350	Protein conserved in bacteria
NHF51_03920	COG2917	probably involved in intracellular septation
NHF51_03925	COG0076	glutamate decarboxylase activity
NHF51_03930	COG1272	protein, Hemolysin III
NHF51_03935	COG2985	domain, Protein
NHF51_03935	COG0569	domain protein
NHF51_03945	COG0477	Major facilitator Superfamily
NHF51_03955	COG3227	Zinc metalloprotease (Elastase)
NHF51_03960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHF51_03965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHF51_03975	COG2731	YhcH YjgK YiaL family protein
NHF51_03985	COG0668	transmembrane transport
NHF51_03995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHF51_04010	COG0789	Transcriptional regulator
NHF51_04045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NHF51_04055	COG0488	(ABC) transporter
NHF51_04065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NHF51_04070	COG0835	chemotaxis
NHF51_04070	COG0784	Response regulator, receiver
NHF51_04075	COG2755	lipolytic protein G-D-S-L family
NHF51_04080	COG4181	ATPase activity
NHF51_04085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NHF51_04090	COG1090	epimerase
NHF51_04095	COG2200	EAL domain
NHF51_04100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHF51_04105	COG4935	Belongs to the peptidase S8 family
NHF51_04105	COG2234	aminopeptidase activity
NHF51_04110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NHF51_04115	COG3171	Protein conserved in bacteria
NHF51_04120	COG2066	Belongs to the glutaminase family
NHF51_04125	COG2897	thiosulfate sulfurtransferase activity
NHF51_04135	COG1132	(ABC) transporter
NHF51_04165	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NHF51_04170	COG3300	MHYT domain
NHF51_04170	COG5001	Diguanylate cyclase
NHF51_04190	COG4628	conserved protein (DUF2132)
NHF51_04195	COG0688	phosphatidylethanolamine metabolic process
NHF51_04200	COG1162	GTPase activity
NHF51_04205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NHF51_04245	COG1278	Cold shock
NHF51_04255	COG0840	transmembrane signaling receptor activity
NHF51_04260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHF51_04310	COG0848	biopolymer transport protein
NHF51_04315	COG0811	peptide transport
NHF51_04320	COG0811	peptide transport
NHF51_04330	COG4206	TonB-dependent receptor
NHF51_04335	COG4174	ABC transporter (Permease)
NHF51_04340	COG4239	(ABC) transporter, permease
NHF51_04345	COG0747	negative chemotaxis
NHF51_04350	COG0444	Belongs to the ABC transporter superfamily
NHF51_04355	COG4608	Belongs to the ABC transporter superfamily
NHF51_04360	COG2195	Cleaves the N-terminal amino acid of tripeptides
NHF51_04365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NHF51_04370	COG1073	alpha beta
NHF51_04385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NHF51_04410	COG0243	molybdopterin cofactor binding
NHF51_04425	COG1116	anion transmembrane transporter activity
NHF51_04425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NHF51_04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHF51_04435	COG1116	anion transmembrane transporter activity
NHF51_04440	COG2146	nitrite reductase [NAD(P)H] activity
NHF51_04440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHF51_04445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHF51_04445	COG2146	nitrite reductase [NAD(P)H] activity
NHF51_04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHF51_04455	COG2313	pseudouridylate synthase activity
NHF51_04460	COG1858	cytochrome C peroxidase
NHF51_04490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHF51_04495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHF51_04515	COG2986	histidine ammonia-lyase
NHF51_04540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHF51_04550	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_04560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHF51_04565	COG0521	Mo-molybdopterin cofactor biosynthetic process
NHF51_04575	COG2966	Psort location CytoplasmicMembrane, score
NHF51_04580	COG3610	response to peptide
NHF51_04590	COG4175	Glycine betaine
NHF51_04595	COG4176	ABC-type proline glycine betaine transport system permease component
NHF51_04600	COG2113	Glycine betaine
NHF51_04605	COG0175	sulfate reduction
NHF51_04610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHF51_04620	COG0384	phenazine biosynthesis protein PhzF
NHF51_04625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NHF51_04640	COG0786	glutamate:sodium symporter activity
NHF51_04645	COG0252	asparaginase activity
NHF51_04650	COG3139	Protein of unknown function (DUF1315)
NHF51_04670	COG0616	signal peptide processing
NHF51_04675	COG0446	pyridine nucleotide-disulphide oxidoreductase
NHF51_04675	COG1902	pentaerythritol trinitrate reductase activity
NHF51_04680	COG0778	Nitroreductase
NHF51_04690	COG2264	protein methyltransferase activity
NHF51_04695	COG0604	alcohol dehydrogenase
NHF51_04700	COG0583	DNA-binding transcription factor activity
NHF51_04705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_04705	COG2190	(PTS) system
NHF51_04705	COG1263	PTS System
NHF51_04710	COG4145	pantothenate transmembrane transporter activity
NHF51_04715	COG3924	membrane
NHF51_04720	COG0439	Biotin carboxylase
NHF51_04725	COG0511	ligase activity, forming carbon-carbon bonds
NHF51_04730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NHF51_04735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHF51_04750	COG3381	protein complex oligomerization
NHF51_04765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NHF51_04770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHF51_04780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHF51_04780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHF51_04795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NHF51_04800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHF51_04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NHF51_04810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NHF51_04815	COG4172	Belongs to the ABC transporter superfamily
NHF51_04825	COG0601	transmembrane transport
NHF51_04835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NHF51_04840	COG0142	geranyltranstransferase activity
NHF51_04845	COG1722	exodeoxyribonuclease VII activity
NHF51_04850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHF51_04855	COG1360	Flagellar Motor Protein
NHF51_04885	COG1534	Rna-binding protein
NHF51_04890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NHF51_04900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NHF51_04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHF51_04910	COG0149	triose-phosphate isomerase activity
NHF51_04915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NHF51_04930	COG0779	Required for maturation of 30S ribosomal subunits
NHF51_04935	COG0195	Participates in both transcription termination and antitermination
NHF51_04940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NHF51_04945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NHF51_04950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NHF51_04955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NHF51_04960	COG1185	polyribonucleotide nucleotidyltransferase activity
NHF51_04965	COG2211	Major facilitator Superfamily
NHF51_04970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NHF51_04975	COG1422	Protein of unknown function (DUF1090)
NHF51_04980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_04985	COG0826	peptidase U32
NHF51_05000	COG0312	modulator of DNA gyrase
NHF51_05015	COG4974	Belongs to the 'phage' integrase family
NHF51_05020	COG1970	mechanosensitive ion channel activity
NHF51_05050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NHF51_05060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NHF51_05065	COG0321	lipoyl(octanoyl) transferase activity
NHF51_05070	COG2921	Belongs to the UPF0250 family
NHF51_05075	COG1686	Belongs to the peptidase S11 family
NHF51_05080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NHF51_05085	COG2951	lytic endotransglycosylase activity
NHF51_05090	COG0772	Belongs to the SEDS family
NHF51_05095	COG0772	Belongs to the SEDS family
NHF51_05100	COG0768	penicillin binding
NHF51_05105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NHF51_05110	COG0799	negative regulation of ribosome biogenesis
NHF51_05115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NHF51_05130	COG0495	leucyl-tRNA aminoacylation
NHF51_05135	COG2888	peptidyl-tyrosine sulfation
NHF51_05140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NHF51_05145	COG4535	Mg2 and Co2 transporter CorC
NHF51_05150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NHF51_05155	COG1702	phosphate starvation-inducible protein PhoH
NHF51_05160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHF51_05165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHF51_05170	COG1335	isochorismatase
NHF51_05175	COG1278	Cold shock
NHF51_05180	COG3706	GGDEF domain
NHF51_05195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHF51_05210	COG2199	diguanylate cyclase activity
NHF51_05220	COG0584	glycerophosphoryl diester phosphodiesterase
NHF51_05225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHF51_05235	COG3647	Membrane
NHF51_05240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NHF51_05250	COG0516	GMP reductase activity
NHF51_05260	COG0642	Histidine kinase
NHF51_05275	COG0300	oxidoreductase activity
NHF51_05300	COG3214	Protein conserved in bacteria
NHF51_05305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NHF51_05315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NHF51_05320	COG1053	succinate dehydrogenase
NHF51_05330	COG0584	glycerophosphoryl diester phosphodiesterase
NHF51_05335	COG1511	domain protein
NHF51_05335	COG3264	Mechanosensitive ion channel
NHF51_05345	COG0739	heme binding
NHF51_05355	COG3121	Chaperone
NHF51_05360	COG3188	usher protein
NHF51_05365	COG3121	Chaperone
NHF51_05380	COG0583	DNA-binding transcription factor activity
NHF51_05400	COG0583	DNA-binding transcription factor activity
NHF51_05405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NHF51_05435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NHF51_05440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NHF51_05450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NHF51_05455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NHF51_05465	COG0180	Tryptophanyl-tRNA synthetase
NHF51_05480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHF51_05490	COG1012	belongs to the aldehyde dehydrogenase family
NHF51_05505	COG3069	C4-dicarboxylate transmembrane transporter activity
NHF51_05510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHF51_05520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHF51_05530	COG0657	acetylesterase activity
NHF51_05540	COG0471	metal ion transport
NHF51_05540	COG0490	domain, Protein
NHF51_05585	COG0012	GTP binding
NHF51_05590	COG0193	aminoacyl-tRNA hydrolase activity
NHF51_05595	COG0737	Belongs to the 5'-nucleotidase family
NHF51_05600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NHF51_05610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NHF51_05615	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NHF51_05620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NHF51_05625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NHF51_05630	COG2890	protein-(glutamine-N5) methyltransferase activity
NHF51_05640	COG2912	Transglutaminase-like superfamily
NHF51_05645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NHF51_05650	COG1301	dicarboxylic acid transport
NHF51_05660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NHF51_05675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHF51_05685	COG1115	amino acid carrier protein
NHF51_05705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NHF51_05710	COG1678	Uncharacterized ACR, COG1678
NHF51_05715	COG0189	ligase activity
NHF51_05720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NHF51_05730	COG3091	SprT-like family
NHF51_05740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NHF51_05770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NHF51_05775	COG0739	heme binding
NHF51_05780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHF51_05785	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NHF51_05785	COG3408	Glycogen debranching enzyme
NHF51_05790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NHF51_05795	COG0583	DNA-binding transcription factor activity
NHF51_05805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NHF51_05815	COG0583	DNA-binding transcription factor activity
NHF51_05820	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_05825	COG0616	signal peptide processing
NHF51_05830	COG3724	N-succinylarginine dihydrolase activity
NHF51_05850	COG0840	transmembrane signaling receptor activity
NHF51_05860	COG2971	BadF BadG BcrA BcrD
NHF51_05870	COG4608	Belongs to the ABC transporter superfamily
NHF51_05875	COG0444	Belongs to the ABC transporter superfamily
NHF51_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHF51_05895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHF51_05925	COG0798	PFAM Bile acid sodium symporter
NHF51_05940	COG1677	Flagellar hook-basal body complex protein FliE
NHF51_05950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHF51_06005	COG1684	flagellar biosynthetic protein fliR
NHF51_06020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHF51_06045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NHF51_06050	COG0643	Histidine kinase
NHF51_06050	COG0784	Response regulator, receiver
NHF51_06050	COG2198	Histidine kinase
NHF51_06055	COG2201	protein-glutamate methylesterase activity
NHF51_06060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHF51_06065	COG1360	Flagellar Motor Protein
NHF51_06070	COG1192	Involved in chromosome partitioning
NHF51_06080	COG0835	chemotaxis
NHF51_06095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHF51_06100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHF51_06105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHF51_06110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NHF51_06115	COG1138	Cytochrome C-type biogenesis protein
NHF51_06120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHF51_06130	COG4235	cytochrome complex assembly
NHF51_06130	COG3088	subunit of a heme lyase
NHF51_06145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NHF51_06150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHF51_06150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHF51_06165	COG0259	pyridoxamine-phosphate oxidase activity
NHF51_06200	COG3153	acetyltransferase
NHF51_06230	COG3158	transport of potassium into the cell
NHF51_06265	COG1012	belongs to the aldehyde dehydrogenase family
NHF51_06265	COG1454	alcohol dehydrogenase
NHF51_06280	COG1882	Formate acetyltransferase
NHF51_06285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHF51_06290	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NHF51_06295	COG4869	propanediol catabolic process
NHF51_06345	COG0582	viral genome integration into host DNA
NHF51_06400	COG2194	sulfuric ester hydrolase activity
NHF51_06420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NHF51_06425	COG2135	peptidase activity
NHF51_06495	COG2204	response regulator
NHF51_06555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NHF51_06565	COG1960	acyl-CoA dehydrogenase activity
NHF51_06570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHF51_06580	COG0469	pyruvate kinase activity
NHF51_06585	COG1737	Transcriptional regulator
NHF51_06590	COG0837	glucose binding
NHF51_06610	COG1091	dTDP-4-dehydrorhamnose reductase activity
NHF51_06635	COG0438	transferase activity, transferring glycosyl groups
NHF51_06640	COG3754	Rhamnan synthesis protein F
NHF51_06665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHF51_06685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NHF51_06690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NHF51_06695	COG2089	acid synthase
NHF51_06750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NHF51_06755	COG0489	protein tyrosine kinase activity
NHF51_06755	COG3206	protein involved in exopolysaccharide biosynthesis
NHF51_06775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHF51_06790	COG3132	Protein of unknown function, DUF480
NHF51_06830	COG1278	Cold shock
NHF51_06855	COG4166	transmembrane transport
NHF51_06860	COG0697	spore germination
NHF51_06865	COG1349	DNA-binding transcription factor activity
NHF51_06870	COG1882	Formate acetyltransferase
NHF51_06875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHF51_06880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHF51_06905	COG4166	transmembrane transport
NHF51_06910	COG0622	Phosphoesterase
NHF51_06925	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NHF51_06930	COG0784	Response regulator, receiver
NHF51_06930	COG0835	chemotaxis
NHF51_06935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NHF51_06940	COG1815	bacterial-type flagellum-dependent cell motility
NHF51_06955	COG1749	Flagellar hook protein flgE
NHF51_06960	COG4787	bacterial-type flagellum-dependent cell motility
NHF51_06970	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NHF51_06975	COG1706	bacterial-type flagellum-dependent cell motility
NHF51_06995	COG2239	Acts as a magnesium transporter
NHF51_07000	COG0248	Ppx GppA phosphatase
NHF51_07005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NHF51_07010	COG2716	regulation of RNA biosynthetic process
NHF51_07035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NHF51_07040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NHF51_07045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NHF51_07050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NHF51_07070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NHF51_07085	COG0590	tRNA wobble adenosine to inosine editing
NHF51_07090	COG0573	inorganic phosphate transmembrane transporter activity
NHF51_07095	COG0581	inorganic phosphate transmembrane transporter activity
NHF51_07100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NHF51_07110	COG1253	flavin adenine dinucleotide binding
NHF51_07125	COG0531	amino acid
NHF51_07140	COG1126	abc transporter atp-binding protein
NHF51_07145	COG0765	amino acid transport
NHF51_07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_07155	COG2271	Major facilitator Superfamily
NHF51_07165	COG2197	response regulator
NHF51_07170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NHF51_07190	COG1785	Belongs to the alkaline phosphatase family
NHF51_07195	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NHF51_07200	COG0477	Major facilitator Superfamily
NHF51_07205	COG0123	including yeast histone deacetylase and acetoin utilization protein
NHF51_07215	COG1199	ATP-dependent helicase activity
NHF51_07230	COG1448	Aminotransferase
NHF51_07235	COG0433	COG0433 Predicted ATPase
NHF51_07250	COG0658	competence protein
NHF51_07250	COG2333	competence protein COMEC
NHF51_07255	COG1132	(ABC) transporter
NHF51_07260	COG1663	tetraacyldisaccharide 4'-kinase activity
NHF51_07265	COG2835	tetraacyldisaccharide 4'-kinase activity
NHF51_07270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NHF51_07285	COG1053	succinate dehydrogenase
NHF51_07300	COG2197	response regulator
NHF51_07305	COG0322	excinuclease ABC activity
NHF51_07330	COG0582	viral genome integration into host DNA
NHF51_07375	COG2261	transglycosylase associated protein
NHF51_07380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHF51_07390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NHF51_07400	COG1074	ATP-dependent DNA helicase activity
NHF51_07405	COG1196	nuclear chromosome segregation
NHF51_07410	COG2199	diguanylate cyclase activity
NHF51_07410	COG2203	Gaf domain
NHF51_07440	COG2119	membrane
NHF51_07445	COG0023	Translation Initiation Factor
NHF51_07485	COG4139	cobalamin transport
NHF51_07490	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NHF51_07495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NHF51_07500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NHF51_07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NHF51_07510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NHF51_07515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NHF51_07525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NHF51_07535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NHF51_07540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHF51_07580	COG0513	Belongs to the DEAD box helicase family
NHF51_07590	COG4104	PAAR repeat-containing protein
NHF51_07605	COG0789	Transcriptional regulator
NHF51_07620	COG0493	'glutamate synthase
NHF51_07625	COG0067	glutamate synthase
NHF51_07625	COG0069	glutamate synthase activity
NHF51_07625	COG0070	glutamate synthase
NHF51_07630	COG1242	4 iron, 4 sulfur cluster binding
NHF51_07685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NHF51_07690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NHF51_07690	COG0574	Belongs to the PEP-utilizing enzyme family
NHF51_07700	COG1472	Belongs to the glycosyl hydrolase 3 family
NHF51_07715	COG1119	ATPase activity
NHF51_07730	COG1464	Belongs to the NlpA lipoprotein family
NHF51_07740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NHF51_07745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHF51_07755	COG0101	tRNA pseudouridine synthase activity
NHF51_07760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NHF51_07765	COG0285	dihydrofolate synthase activity
NHF51_07770	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NHF51_07775	COG2920	part of a sulfur-relay system
NHF51_07780	COG1289	transmembrane transporter activity
NHF51_07790	COG0670	Belongs to the BI1 family
NHF51_07800	COG3069	C4-dicarboxylate transmembrane transporter activity
NHF51_07805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHF51_07830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NHF51_07840	COG2175	clavaminate synthase activity
NHF51_07845	COG3246	L-lysine catabolic process to acetate
NHF51_07850	COG0477	Major facilitator Superfamily
NHF51_07860	COG2855	membrane
NHF51_07885	COG4447	cellulose binding
NHF51_07905	COG0318	PFAM AMP-dependent synthetase and ligase
NHF51_07910	COG0840	transmembrane signaling receptor activity
NHF51_07920	COG0564	pseudouridine synthase activity
NHF51_07935	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NHF51_07945	COG0625	glutathione transferase activity
NHF51_07950	COG0625	glutathione transferase activity
NHF51_07965	COG0367	asparagine synthase
NHF51_07975	COG0647	UMP catabolic process
NHF51_07985	COG1902	pentaerythritol trinitrate reductase activity
NHF51_07990	COG1253	flavin adenine dinucleotide binding
NHF51_08000	COG0247	lactate metabolic process
NHF51_08000	COG0277	FAD linked oxidase domain protein
NHF51_08010	COG2050	protein possibly involved in aromatic compounds catabolism
NHF51_08015	COG0513	Belongs to the DEAD box helicase family
NHF51_08020	COG2056	Na+-H+ antiporter family
NHF51_08025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NHF51_08035	COG0483	inositol monophosphate 1-phosphatase activity
NHF51_08050	COG0625	glutathione transferase activity
NHF51_08055	COG2814	Major facilitator Superfamily
NHF51_08060	COG0673	inositol 2-dehydrogenase activity
NHF51_08070	COG1879	ABC-type sugar transport system periplasmic component
NHF51_08075	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHF51_08080	COG1129	ABC transporter
NHF51_08085	COG1609	Transcriptional regulator
NHF51_08105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHF51_08110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHF51_08115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NHF51_08120	COG0509	glycine decarboxylation via glycine cleavage system
NHF51_08125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHF51_08125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHF51_08215	COG3634	alkyl hydroperoxide reductase activity
NHF51_08225	COG0517	IMP dehydrogenase activity
NHF51_08230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NHF51_08235	COG0343	queuine tRNA-ribosyltransferase activity
NHF51_08240	COG1862	Preprotein translocase
NHF51_08245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHF51_08250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHF51_08265	COG0826	peptidase U32
NHF51_08270	COG0826	peptidase U32
NHF51_08275	COG3154	lipid carrier protein
NHF51_08295	COG1104	cysteine desulfurase activity
NHF51_08300	COG0822	iron-sulfur transferase activity
NHF51_08310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NHF51_08315	COG0443	Heat shock 70 kDa protein
NHF51_08320	COG0633	Ferredoxin
NHF51_08335	COG0105	UTP biosynthetic process
NHF51_08340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NHF51_08360	COG0124	histidyl-tRNA synthetase
NHF51_08365	COG2976	Protein conserved in bacteria
NHF51_08370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHF51_08375	COG1160	GTP binding
NHF51_08380	COG1645	bacterial-type flagellum-dependent swarming motility
NHF51_08385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NHF51_08390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHF51_08390	COG0047	phosphoribosylformylglycinamidine synthase activity
NHF51_08395	COG1007	ATP synthesis coupled electron transport
NHF51_08400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_08410	COG0713	ATP synthesis coupled electron transport
NHF51_08415	COG0839	Belongs to the complex I subunit 6 family
NHF51_08420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_08425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NHF51_08430	COG1034	ATP synthesis coupled electron transport
NHF51_08445	COG0649	NAD binding
NHF51_08445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_08450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_08455	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_08460	COG1360	Flagellar Motor Protein
NHF51_08465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHF51_08480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NHF51_08490	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NHF51_08500	COG0724	RNA recognition motif
NHF51_08505	COG4989	oxidoreductase activity
NHF51_08530	COG3437	response regulator, receiver
NHF51_08535	COG0583	DNA-binding transcription factor activity
NHF51_08545	COG3300	MHYT domain
NHF51_08545	COG5001	Diguanylate cyclase
NHF51_08550	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NHF51_08580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NHF51_08585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NHF51_08590	COG0539	negative regulation of cytoplasmic translation
NHF51_08595	COG0776	regulation of translation
NHF51_08605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NHF51_08625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NHF51_08630	COG0602	queuosine metabolic process
NHF51_08635	COG3530	Putative quorum-sensing-regulated virulence factor
NHF51_08640	COG2096	Adenosyltransferase
NHF51_08645	COG2916	Histone family protein nucleoid-structuring protein H-NS
NHF51_08650	COG1757	Na H antiporter
NHF51_08655	COG1435	thymidine kinase activity
NHF51_08675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NHF51_08695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NHF51_08700	COG0626	cystathionine gamma-synthase activity
NHF51_08710	COG2910	NAD(P)H-binding
NHF51_08720	COG2207	Transcriptional regulator
NHF51_08720	COG3708	Transcriptional regulator
NHF51_08740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NHF51_08745	COG0517	IMP dehydrogenase activity
NHF51_08745	COG0617	tRNA 3'-terminal CCA addition
NHF51_08745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHF51_08760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHF51_08765	COG1686	Belongs to the peptidase S11 family
NHF51_08775	COG3088	subunit of a heme lyase
NHF51_08775	COG4235	cytochrome complex assembly
NHF51_08790	COG3301	Polysulphide reductase, NrfD
NHF51_08795	COG0437	4 iron, 4 sulfur cluster binding
NHF51_08800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NHF51_08815	COG0247	lactate metabolic process
NHF51_08820	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NHF51_08825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NHF51_08830	COG3012	SEC-C Motif Domain Protein
NHF51_08835	COG1846	Transcriptional regulator
NHF51_08835	COG1940	carbohydrate kinase activity
NHF51_08840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NHF51_08845	COG0569	domain protein
NHF51_08845	COG2985	domain, Protein
NHF51_08855	COG0556	nucleotide-excision repair
NHF51_08865	COG0586	Pfam SNARE associated Golgi protein
NHF51_08870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NHF51_08875	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NHF51_08885	COG2719	SpoVR family
NHF51_08890	COG2718	Belongs to the UPF0229 family
NHF51_08895	COG2766	serine protein kinase
NHF51_08900	COG0514	ATP-dependent DNA helicase (RecQ)
NHF51_08905	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NHF51_08910	COG0814	amino acid
NHF51_08940	COG0058	SHG alpha-glucan phosphorylase activity
NHF51_08950	COG0471	metal ion transport
NHF51_08955	COG3118	belongs to the thioredoxin family
NHF51_08965	COG1132	(ABC) transporter
NHF51_08970	COG1132	(ABC) transporter
NHF51_08980	COG2501	S4 domain
NHF51_08990	COG3243	poly(R)-hydroxyalkanoic acid synthase
NHF51_09010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NHF51_09015	COG2329	Antibiotic biosynthesis monooxygenase
NHF51_09040	COG1742	UPF0060 membrane protein
NHF51_09050	COG0513	Belongs to the DEAD box helicase family
NHF51_09055	COG0386	Belongs to the glutathione peroxidase family
NHF51_09065	COG1181	Belongs to the D-alanine--D-alanine ligase family
NHF51_09075	COG3148	PFAM DTW domain containing protein
NHF51_09080	COG0730	response to heat
NHF51_09085	COG0583	DNA-binding transcription factor activity
NHF51_09100	COG3593	DNA synthesis involved in DNA repair
NHF51_09150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHF51_09155	COG1011	Hydrolase
NHF51_09160	COG1473	amidohydrolase
NHF51_09165	COG0205	6-phosphofructokinase activity
NHF51_09175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NHF51_09180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHF51_09190	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NHF51_09230	COG0384	phenazine biosynthesis protein PhzF
NHF51_09235	COG1280	lysine exporter protein (LysE YggA)
NHF51_09240	COG2824	Alkylphosphonate utilization operon protein PhnA
NHF51_09275	COG2840	Smr protein MutS2
NHF51_09280	COG2890	protein-(glutamine-N5) methyltransferase activity
NHF51_09285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NHF51_09295	COG0513	Belongs to the DEAD box helicase family
NHF51_09315	COG0814	amino acid
NHF51_09320	COG1609	Transcriptional regulator
NHF51_09325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_09325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_09330	COG1105	Belongs to the carbohydrate kinase PfkB family
NHF51_09335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_09335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_09335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NHF51_09340	COG1609	Transcriptional regulator
NHF51_09350	COG1263	PTS System
NHF51_09350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_09355	COG0383	alpha-mannosidase activity
NHF51_09360	COG0738	Major facilitator superfamily
NHF51_09370	COG3313	Fe-S protein
NHF51_09375	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NHF51_09380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHF51_09385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHF51_09390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHF51_09400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHF51_09430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHF51_09435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NHF51_09440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NHF51_09445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NHF51_09450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NHF51_09455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHF51_09455	COG0072	phenylalanine-tRNA ligase activity
NHF51_09460	COG0776	regulation of translation
NHF51_09465	COG0784	Response regulator, receiver
NHF51_09465	COG2205	protein histidine kinase activity
NHF51_09490	COG2199	diguanylate cyclase activity
NHF51_09495	COG1609	Transcriptional regulator
NHF51_09500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHF51_09505	COG1879	ABC-type sugar transport system periplasmic component
NHF51_09510	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHF51_09515	COG1129	ABC transporter
NHF51_09520	COG1869	D-ribose catabolic process
NHF51_09525	COG0625	glutathione transferase activity
NHF51_09540	COG0037	tRNA processing
NHF51_09545	COG0589	response to stress
NHF51_09550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NHF51_09575	COG2010	Cytochrome c
NHF51_09590	COG3278	Belongs to the heme-copper respiratory oxidase family
NHF51_09600	COG1956	GAF domain-containing protein
NHF51_09605	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NHF51_09615	COG0308	aminopeptidase N
NHF51_09625	COG2902	Dehydrogenase
NHF51_09630	COG0167	dihydroorotate dehydrogenase activity
NHF51_09640	COG0116	Belongs to the methyltransferase superfamily
NHF51_09640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NHF51_09650	COG0488	(ABC) transporter
NHF51_09665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHF51_09670	COG1067	ATP-dependent peptidase activity
NHF51_09710	COG4128	Pfam Zonular occludens toxin
NHF51_09730	COG3141	response to X-ray
NHF51_09740	COG2995	paraquat-inducible protein a
NHF51_09745	COG3008	intermembrane lipid transfer
NHF51_09750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NHF51_09750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHF51_09760	COG2801	Transposase and inactivated derivatives
NHF51_09785	COG0084	hydrolase, TatD family'
NHF51_09790	COG0470	DNA polymerase III
NHF51_09795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NHF51_09800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NHF51_09805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHF51_09810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHF51_09815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHF51_09820	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_09830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHF51_09835	COG0416	fatty acid biosynthetic process
NHF51_09840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NHF51_09845	COG1399	metal-binding, possibly nucleic acid-binding protein
NHF51_09865	COG0546	phosphoglycolate phosphatase activity
NHF51_09875	COG1530	ribonuclease E activity
NHF51_09880	COG0306	phosphate transporter
NHF51_09885	COG0717	Belongs to the dCTP deaminase family
NHF51_09890	COG0572	uridine kinase
NHF51_09895	COG0489	protein tyrosine kinase activity
NHF51_09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHF51_09900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHF51_09910	COG1254	Belongs to the acylphosphatase family
NHF51_09915	COG0840	transmembrane signaling receptor activity
NHF51_09925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NHF51_09940	COG0709	Synthesizes selenophosphate from selenide and ATP
NHF51_09945	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NHF51_09950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHF51_09955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NHF51_09965	COG1643	Atp-dependent helicase
NHF51_09970	COG0517	IMP dehydrogenase activity
NHF51_09970	COG0617	tRNA 3'-terminal CCA addition
NHF51_09970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHF51_09975	COG2197	response regulator
NHF51_09980	COG3314	Sporulation integral membrane protein YlbJ
NHF51_09990	COG0583	DNA-binding transcription factor activity
NHF51_10000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NHF51_10010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NHF51_10015	COG2832	Protein of unknown function (DUF454)
NHF51_10020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHF51_10030	COG2197	response regulator
NHF51_10050	COG0318	PFAM AMP-dependent synthetase and ligase
NHF51_10055	COG2267	carboxylic ester hydrolase activity
NHF51_10065	COG1214	PFAM Peptidase M22, glycoprotease
NHF51_10070	COG1199	ATP-dependent helicase activity
NHF51_10080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NHF51_10085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NHF51_10090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NHF51_10095	COG0131	Imidazoleglycerol-phosphate dehydratase
NHF51_10095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NHF51_10100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NHF51_10105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NHF51_10110	COG3437	response regulator, receiver
NHF51_10115	COG2198	Histidine kinase
NHF51_10115	COG0784	Response regulator, receiver
NHF51_10115	COG2205	protein histidine kinase activity
NHF51_10120	COG0107	imidazoleglycerol-phosphate synthase activity
NHF51_10125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NHF51_10125	COG0140	phosphoribosyl-ATP diphosphatase activity
NHF51_10155	COG0318	PFAM AMP-dependent synthetase and ligase
NHF51_10160	COG1288	antiporter activity
NHF51_10165	COG3134	Outer membrane lipoprotein
NHF51_10170	COG3134	Outer membrane lipoprotein
NHF51_10185	COG4681	YaeQ
NHF51_10195	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHF51_10195	COG1024	Enoyl-CoA hydratase
NHF51_10200	COG0183	Belongs to the thiolase family
NHF51_10205	COG0714	Associated with various cellular activities
NHF51_10235	COG1595	DNA-templated transcription, initiation
NHF51_10245	COG2067	long-chain fatty acid transport protein
NHF51_10250	COG2067	long-chain fatty acid transport protein
NHF51_10255	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NHF51_10260	COG2067	long-chain fatty acid transport protein
NHF51_10280	COG3123	guanosine phosphorylase activity
NHF51_10285	COG1760	l-serine dehydratase
NHF51_10290	COG1760	l-serine dehydratase
NHF51_10295	COG2951	lytic endotransglycosylase activity
NHF51_10300	COG3100	YcgL domain-containing protein
NHF51_10305	COG0850	regulation of cytokinetic process
NHF51_10310	COG2894	cell division
NHF51_10315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NHF51_10320	COG3099	Belongs to the UPF0263 family
NHF51_10325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHF51_10365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NHF51_10370	COG0697	spore germination
NHF51_10375	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NHF51_10380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHF51_10390	COG0307	riboflavin synthase, alpha
NHF51_10400	COG0534	Mate efflux family protein
NHF51_10430	COG0417	DNA replication proofreading
NHF51_10450	COG1560	Kdo2-lipid A biosynthetic process
NHF51_10455	COG1560	Kdo2-lipid A biosynthetic process
NHF51_10465	COG0583	DNA-binding transcription factor activity
NHF51_10470	COG0673	inositol 2-dehydrogenase activity
NHF51_10475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NHF51_10495	COG2723	6-phospho-beta-galactosidase activity
NHF51_10500	COG0583	DNA-binding transcription factor activity
NHF51_10505	COG3706	GGDEF domain
NHF51_10515	COG0243	molybdopterin cofactor binding
NHF51_10520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NHF51_10570	COG1278	Cold shock
NHF51_10580	COG0604	alcohol dehydrogenase
NHF51_10585	COG1733	regulation of RNA biosynthetic process
NHF51_10590	COG0656	L-ascorbic acid biosynthetic process
NHF51_10610	COG0667	Aldo Keto reductase
NHF51_10615	COG1979	alcohol dehydrogenase
NHF51_10620	COG0583	DNA-binding transcription factor activity
NHF51_10630	COG0583	DNA-binding transcription factor activity
NHF51_10665	COG2801	Transposase and inactivated derivatives
NHF51_10725	COG0730	response to heat
NHF51_10735	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_10745	COG1024	Enoyl-CoA hydratase
NHF51_10750	COG1024	Enoyl-CoA hydratase
NHF51_10755	COG1960	acyl-CoA dehydrogenase activity
NHF51_10765	COG1960	acyl-CoA dehydrogenase activity
NHF51_10770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NHF51_10775	COG1024	Enoyl-CoA hydratase
NHF51_10800	COG1584	GPR1 FUN34 yaaH family protein
NHF51_10815	COG1115	amino acid carrier protein
NHF51_10820	COG1024	Enoyl-CoA hydratase
NHF51_10835	COG3162	membrane
NHF51_10840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHF51_10845	COG0488	(ABC) transporter
NHF51_10855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHF51_10860	COG0776	regulation of translation
NHF51_10865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHF51_10870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NHF51_10875	COG0740	serine-type endopeptidase activity
NHF51_10880	COG0544	peptidyl-prolyl cis-trans isomerase activity
NHF51_10890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NHF51_10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
NHF51_10900	COG1136	(ABC) transporter
NHF51_10905	COG4591	ABC-type transport system involved in lipoprotein release permease component
NHF51_10915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NHF51_10920	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NHF51_10925	COG4166	transmembrane transport
NHF51_10930	COG0697	spore germination
NHF51_10940	COG2062	phosphohistidine phosphatase, SixA
NHF51_10970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NHF51_10970	COG0519	Catalyzes the synthesis of GMP from XMP
NHF51_10975	COG0516	GMP reductase activity
NHF51_10975	COG0517	IMP dehydrogenase activity
NHF51_10985	COG0366	Alpha amylase catalytic
NHF51_10985	COG1874	Beta-galactosidase
NHF51_11005	COG0697	spore germination
NHF51_11010	COG1570	exodeoxyribonuclease VII activity
NHF51_11020	COG2885	chlorophyll binding
NHF51_11025	COG2199	diguanylate cyclase activity
NHF51_11040	COG2154	pterin-4-alpha-carbinolamine dehydratase
NHF51_11050	COG3768	UPF0283 membrane protein
NHF51_11055	COG3106	COG3106 Predicted ATPase
NHF51_11070	COG1842	Phage shock protein A
NHF51_11075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NHF51_11085	COG4168	peptide transport system, permease
NHF51_11090	COG4171	peptide transport system, permease
NHF51_11100	COG4172	Belongs to the ABC transporter superfamily
NHF51_11110	COG1609	Transcriptional regulator
NHF51_11115	COG1263	PTS System
NHF51_11115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_11120	COG2723	6-phospho-beta-galactosidase activity
NHF51_11125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NHF51_11130	COG1286	toxin biosynthetic process
NHF51_11135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NHF51_11140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NHF51_11145	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NHF51_11150	COG1674	ftsk spoiiie
NHF51_11150	COG0531	amino acid
NHF51_11160	COG0686	Belongs to the AlaDH PNT family
NHF51_11165	COG0492	ferredoxin-NADP+ reductase activity
NHF51_11170	COG3706	GGDEF domain
NHF51_11175	COG3134	Outer membrane lipoprotein
NHF51_11180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NHF51_11185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NHF51_11190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NHF51_11195	COG0542	response to heat
NHF51_11200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NHF51_11205	COG1278	Cold shock
NHF51_11210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHF51_11225	COG1944	ATP diphosphatase activity
NHF51_11230	COG2116	formate transmembrane transporter activity
NHF51_11235	COG1882	Formate acetyltransferase
NHF51_11240	COG2983	Belongs to the UPF0260 family
NHF51_11245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NHF51_11250	COG0045	succinate-CoA ligase (ADP-forming) activity
NHF51_11255	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHF51_11260	COG0567	Dehydrogenase, E1 component
NHF51_11270	COG1053	succinate dehydrogenase
NHF51_11275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NHF51_11280	COG2009	succinate dehydrogenase
NHF51_11300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHF51_11305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NHF51_11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHF51_11315	COG3069	C4-dicarboxylate transmembrane transporter activity
NHF51_11330	COG1451	nucleotide metabolic process
NHF51_11345	COG0254	rRNA binding
NHF51_11350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NHF51_11355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NHF51_11365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NHF51_11390	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_11395	COG1414	Transcriptional regulator
NHF51_11400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHF51_11405	COG0800	Aldolase
NHF51_11415	COG0392	lysyltransferase activity
NHF51_11415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NHF51_11435	COG2925	Exonuclease
NHF51_11450	COG1380	Effector of murein hydrolase LrgA
NHF51_11455	COG1346	cytolysis
NHF51_11460	COG0295	cytidine deaminase activity
NHF51_11465	COG1022	Amp-dependent synthetase and ligase
NHF51_11480	COG0861	Integral membrane protein TerC family
NHF51_11485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NHF51_11490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NHF51_11495	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NHF51_11535	COG4771	TonB-dependent receptor
NHF51_11540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHF51_11545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHF51_11550	COG1120	ATPase activity
NHF51_11560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHF51_11565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NHF51_11575	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_11580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NHF51_11585	COG1535	isochorismatase
NHF51_11585	COG3433	isochorismatase activity
NHF51_11590	COG1021	2,3-dihydroxybenzoate-AMP ligase
NHF51_11610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NHF51_11615	COG3300	MHYT domain
NHF51_11615	COG5001	Diguanylate cyclase
NHF51_11630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHF51_11640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NHF51_11645	COG0563	adenylate kinase activity
NHF51_11650	COG0326	Molecular chaperone. Has ATPase activity
NHF51_11655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NHF51_11680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_11690	COG3158	transport of potassium into the cell
NHF51_11695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_11700	COG0651	ATP synthesis coupled electron transport
NHF51_11705	COG0650	Formate hydrogenlyase subunit 4
NHF51_11710	COG3261	NADH dehydrogenase
NHF51_11710	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NHF51_11715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHF51_11720	COG3260	NADH ubiquinone oxidoreductase 20
NHF51_11730	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NHF51_11740	COG1921	L-seryl-tRNASec selenium transferase activity
NHF51_11750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NHF51_11755	COG0298	carbon dioxide binding
NHF51_11765	COG0309	Hydrogenase expression formation protein (HypE)
NHF51_11770	COG0375	protein maturation
NHF51_11780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NHF51_11785	COG1124	(ABC) transporter
NHF51_11795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHF51_11805	COG0747	negative chemotaxis
NHF51_11810	COG1773	rubredoxin
NHF51_11815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NHF51_11820	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NHF51_11825	COG5557	Pfam Polysulphide reductase, NrfD
NHF51_11830	COG0437	4 iron, 4 sulfur cluster binding
NHF51_11835	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NHF51_11850	COG0659	secondary active sulfate transmembrane transporter activity
NHF51_11870	COG2200	EAL domain
NHF51_11895	COG0559	Belongs to the binding-protein-dependent transport system permease family
NHF51_11920	COG0672	)-iron permease
NHF51_11925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NHF51_11925	COG0493	'glutamate synthase
NHF51_11945	COG2814	Major facilitator Superfamily
NHF51_11970	COG0577	efflux transmembrane transporter activity
NHF51_11995	COG2315	Protein conserved in bacteria
NHF51_12010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHF51_12015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NHF51_12015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NHF51_12020	COG0527	aspartate kinase activity
NHF51_12030	COG1368	sulfuric ester hydrolase activity
NHF51_12035	COG1619	proteins homologs of microcin C7 resistance protein MccF
NHF51_12040	COG0393	Putative heavy-metal-binding
NHF51_12045	COG1252	NADH dehydrogenase
NHF51_12065	COG2354	Protein conserved in bacteria
NHF51_12075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHF51_12080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHF51_12115	COG0537	adenosine 5'-monophosphoramidase activity
NHF51_12135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NHF51_12150	COG1301	dicarboxylic acid transport
NHF51_12160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHF51_12165	COG0861	Integral membrane protein TerC family
NHF51_12175	COG0444	Belongs to the ABC transporter superfamily
NHF51_12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHF51_12185	COG0601	transmembrane transport
NHF51_12195	COG2095	MarC family integral membrane protein
NHF51_12200	COG1012	belongs to the aldehyde dehydrogenase family
NHF51_12200	COG1454	alcohol dehydrogenase
NHF51_12205	COG2199	diguanylate cyclase activity
NHF51_12205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NHF51_12245	COG3275	phosphorelay sensor kinase activity
NHF51_12250	COG3279	Response regulator of the LytR AlgR family
NHF51_12255	COG1966	Carbon starvation protein
NHF51_12260	COG3264	Mechanosensitive ion channel
NHF51_12260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NHF51_12270	COG1566	PFAM secretion protein HlyD family protein
NHF51_12275	COG1061	Type III restriction enzyme res subunit
NHF51_12280	COG2027	D-alanyl-D-alanine carboxypeptidase
NHF51_12285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NHF51_12295	COG0436	Aminotransferase
NHF51_12300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NHF51_12335	COG2207	Transcriptional regulator
NHF51_12355	COG4657	Part of a membrane complex involved in electron transport
NHF51_12360	COG2878	Part of a membrane complex involved in electron transport
NHF51_12370	COG4658	electron transport chain
NHF51_12375	COG4659	FMN binding
NHF51_12380	COG4660	Part of a membrane complex involved in electron transport
NHF51_12385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NHF51_12390	COG0346	lactoylglutathione lyase activity
NHF51_12405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NHF51_12465	COG0301	tRNA thio-modification
NHF51_12465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHF51_12475	COG4953	penicillin-binding protein 1C
NHF51_12480	COG2373	Large extracellular alpha-helical protein
NHF51_12510	COG2271	Major facilitator Superfamily
NHF51_12515	COG1082	Xylose isomerase domain protein TIM barrel
NHF51_12520	COG2188	Transcriptional regulator
NHF51_12530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHF51_12550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_12560	COG2431	L-lysine efflux transmembrane transporter activity
NHF51_12575	COG1393	Belongs to the ArsC family
NHF51_12585	COG4783	chaperone-mediated protein folding
NHF51_12590	COG0425	Belongs to the sulfur carrier protein TusA family
NHF51_12610	COG3842	ATPase activity
NHF51_12615	COG3833	ABC-type maltose transport systems, permease component
NHF51_12620	COG1175	transmembrane transport
NHF51_12630	COG3081	Nucleoid-associated protein
NHF51_12635	COG3082	Protein of unknown function (DUF1414)
NHF51_12640	COG3083	sulfuric ester hydrolase activity
NHF51_12645	COG4771	TonB-dependent receptor
NHF51_12650	COG1770	oligopeptidase
NHF51_12670	COG4574	serine-type endopeptidase inhibitor activity
NHF51_12675	COG3085	chromosome segregation
NHF51_12680	COG0583	DNA-binding transcription factor activity
NHF51_12685	COG0287	Prephenate dehydrogenase
NHF51_12685	COG1605	Chorismate mutase
NHF51_12690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NHF51_12695	COG0584	glycerophosphoryl diester phosphodiesterase
NHF51_12705	COG1349	DNA-binding transcription factor activity
NHF51_12710	COG2271	Major facilitator Superfamily
NHF51_12715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NHF51_12720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NHF51_12725	COG0583	DNA-binding transcription factor activity
NHF51_12750	COG0656	L-ascorbic acid biosynthetic process
NHF51_12755	COG2814	Major facilitator Superfamily
NHF51_12765	COG1294	oxidase, subunit
NHF51_12775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHF51_12790	COG1595	DNA-templated transcription, initiation
NHF51_12805	COG2979	Protein of unknown function (DUF533)
NHF51_12835	COG0583	DNA-binding transcription factor activity
NHF51_12845	COG2807	transmembrane transport
NHF51_12850	COG1187	pseudouridine synthase activity
NHF51_12855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NHF51_12870	COG1061	Type III restriction enzyme res subunit
NHF51_12885	COG1166	arginine decarboxylase activity
NHF51_12890	COG2195	Cleaves the N-terminal amino acid of tripeptides
NHF51_12900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NHF51_12915	COG0583	DNA-binding transcription factor activity
NHF51_12925	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NHF51_12935	COG0302	gtp cyclohydrolase
NHF51_12945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHF51_12950	COG2267	carboxylic ester hydrolase activity
NHF51_12955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NHF51_12970	COG0314	molybdopterin synthase activity
NHF51_12975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NHF51_12980	COG0315	cyclic pyranopterin monophosphate synthase activity
NHF51_12985	COG0521	Mo-molybdopterin cofactor biosynthetic process
NHF51_12990	COG3005	denitrification pathway
NHF51_13000	COG0348	domain, Protein
NHF51_13005	COG0437	4 iron, 4 sulfur cluster binding
NHF51_13010	COG0243	molybdopterin cofactor binding
NHF51_13020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_13020	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHF51_13025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NHF51_13030	COG3850	Histidine kinase
NHF51_13035	COG2197	response regulator
NHF51_13070	COG0121	glutamine amidotransferase
NHF51_13075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NHF51_13085	COG3437	response regulator, receiver
NHF51_13085	COG0784	Response regulator, receiver
NHF51_13095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NHF51_13100	COG0328	RNA-DNA hybrid ribonuclease activity
NHF51_13105	COG2226	methyltransferase
NHF51_13110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHF51_13115	COG0741	lytic transglycosylase activity
NHF51_13115	COG1388	LysM domain
NHF51_13120	COG3021	interspecies interaction between organisms
NHF51_13130	COG1607	acyl-coa hydrolase
NHF51_13145	COG0741	lytic transglycosylase activity
NHF51_13155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NHF51_13175	COG2911	Protein conserved in bacteria
NHF51_13180	COG0729	surface antigen
NHF51_13190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHF51_13200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHF51_13205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHF51_13210	COG4134	Bacterial extracellular solute-binding protein
NHF51_13220	COG4136	ATPase activity
NHF51_13225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHF51_13230	COG2951	lytic endotransglycosylase activity
NHF51_13235	COG1846	Transcriptional regulator
NHF51_13245	COG0033	Phosphoglucomutase
NHF51_13250	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NHF51_13255	COG0596	Alpha beta hydrolase
NHF51_13270	COG0716	FMN binding
NHF51_13280	COG0735	belongs to the Fur family
NHF51_13285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHF51_13290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NHF51_13295	COG2080	2 iron, 2 sulfur cluster binding
NHF51_13320	COG1263	PTS System
NHF51_13320	COG2190	(PTS) system
NHF51_13320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_13325	COG0363	glucosamine-6-phosphate deaminase activity
NHF51_13330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NHF51_13335	COG1846	Transcriptional regulator
NHF51_13335	COG1940	carbohydrate kinase activity
NHF51_13340	COG2194	sulfuric ester hydrolase activity
NHF51_13345	COG0217	transcriptional regulatory protein
NHF51_13350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NHF51_13355	COG1801	Protein of unknown function DUF72
NHF51_13360	COG4106	trans-aconitate 2-methyltransferase activity
NHF51_13365	COG0500	methyltransferase
NHF51_13385	COG0583	DNA-binding transcription factor activity
NHF51_13390	COG0791	NLP P60 protein
NHF51_13405	COG1309	transcriptional regulator
NHF51_13440	COG0534	Mate efflux family protein
NHF51_13450	COG2841	Protein conserved in bacteria
NHF51_13455	COG0633	Ferredoxin
NHF51_13455	COG3217	Mosc domain protein beta barrel domain protein
NHF51_13455	COG0633	Ferredoxin
NHF51_13455	COG3217	Mosc domain protein beta barrel domain protein
NHF51_13460	COG0501	Belongs to the peptidase M48B family
NHF51_13465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NHF51_13470	COG2226	methyltransferase
NHF51_13470	COG1073	alpha beta
NHF51_13475	COG0156	8-amino-7-oxononanoate synthase activity
NHF51_13480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NHF51_13485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHF51_13495	COG0017	Asparaginyl-tRNA synthetase
NHF51_13500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NHF51_13510	COG1473	amidohydrolase
NHF51_13515	COG3069	C4-dicarboxylate transmembrane transporter activity
NHF51_13525	COG1393	Belongs to the ArsC family
NHF51_13530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHF51_13535	COG1876	peptidase activity
NHF51_13545	COG3263	regulation of cellular component size
NHF51_13555	COG1280	lysine exporter protein (LysE YggA)
NHF51_13580	COG0564	pseudouridine synthase activity
NHF51_13590	COG1454	alcohol dehydrogenase
NHF51_13595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHF51_13600	COG0702	epimerase
NHF51_13605	COG2914	Belongs to the UPF0125 (RnfH) family
NHF51_13610	COG2867	negative regulation of translational initiation
NHF51_13620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NHF51_13630	COG0582	viral genome integration into host DNA
NHF51_13655	COG3459	Glycosyltransferase 36 associated
NHF51_13700	COG2823	Periplasmic or secreted lipoprotein
NHF51_13730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NHF51_13735	COG2823	Periplasmic or secreted lipoprotein
NHF51_13750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHF51_13755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHF51_13760	COG1309	transcriptional regulator
NHF51_13775	COG1946	Acyl-CoA thioesterase
NHF51_13800	COG1984	allophanate hydrolase subunit 2
NHF51_13805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NHF51_13820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NHF51_13830	COG0009	L-threonylcarbamoyladenylate synthase
NHF51_13840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NHF51_13845	COG0512	Glutamine amidotransferase of anthranilate synthase
NHF51_13845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NHF51_13850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NHF51_13855	COG0134	indole-3-glycerol-phosphate synthase activity
NHF51_13855	COG0135	phosphoribosylanthranilate isomerase activity
NHF51_13860	COG0133	tryptophan synthase activity
NHF51_13865	COG0159	tryptophan synthase activity
NHF51_13910	COG4521	taurine ABC transporter
NHF51_13915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NHF51_13920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHF51_13930	COG2175	clavaminate synthase activity
NHF51_13935	COG5507	3-demethylubiquinone-9 3-methyltransferase
NHF51_13940	COG2814	Major facilitator Superfamily
NHF51_13950	COG0109	protoheme IX farnesyltransferase activity
NHF51_13955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NHF51_13960	COG1845	cytochrome c oxidase, subunit III
NHF51_13965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHF51_13970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHF51_13975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHF51_13980	COG0583	DNA-binding transcription factor activity
NHF51_14015	COG0745	RESPONSE REGULATOR receiver
NHF51_14025	COG0708	Exodeoxyribonuclease III
NHF51_14045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHF51_14050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHF51_14065	COG0095	Lipoate-protein ligase
NHF51_14085	COG1285	pathogenesis
NHF51_14090	COG0484	heat shock protein binding
NHF51_14095	COG0443	Heat shock 70 kDa protein
NHF51_14100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NHF51_14105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NHF51_14110	COG0497	DNA recombination
NHF51_14115	COG1227	inorganic diphosphatase activity
NHF51_14125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHF51_14130	COG1136	(ABC) transporter
NHF51_14130	COG0577	efflux transmembrane transporter activity
NHF51_14140	COG2375	cellular response to nickel ion
NHF51_14145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NHF51_14155	COG2916	Histone family protein nucleoid-structuring protein H-NS
NHF51_14160	COG0583	DNA-binding transcription factor activity
NHF51_14165	COG2610	gluconate transmembrane transporter activity
NHF51_14170	COG3048	D-serine ammonia-lyase activity
NHF51_14180	COG0538	isocitrate dehydrogenase activity
NHF51_14185	COG2207	Transcriptional regulator
NHF51_14205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_14215	COG4932	domain protein
NHF51_14215	COG5492	domain, Protein
NHF51_14225	COG2814	Major facilitator Superfamily
NHF51_14225	COG0477	Major facilitator Superfamily
NHF51_14235	COG1940	carbohydrate kinase activity
NHF51_14255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_14255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_14255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_14265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHF51_14275	COG1187	pseudouridine synthase activity
NHF51_14285	COG0482	sulfurtransferase activity
NHF51_14290	COG2915	High frequency lysogenization protein hflD homolog
NHF51_14295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHF51_14300	COG2850	peptidyl-arginine hydroxylation
NHF51_14305	COG0469	pyruvate kinase activity
NHF51_14310	COG1196	nuclear chromosome segregation
NHF51_14310	COG3264	Mechanosensitive ion channel
NHF51_14320	COG2706	6-phosphogluconolactonase activity
NHF51_14340	COG0281	malic enzyme
NHF51_14345	COG0746	molybdenum cofactor guanylyltransferase activity
NHF51_14350	COG1763	Mo-molybdopterin cofactor biosynthetic process
NHF51_14355	COG1289	transmembrane transporter activity
NHF51_14390	COG3220	belongs to the UPF0276 family
NHF51_14410	COG4319	ketosteroid isomerase
NHF51_14415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NHF51_14420	COG0083	homoserine kinase activity
NHF51_14430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NHF51_14435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NHF51_14450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NHF51_14460	COG0745	RESPONSE REGULATOR receiver
NHF51_14475	COG4988	ABC transporter
NHF51_14480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NHF51_14500	COG1720	tRNA m6t6A37 methyltransferase activity
NHF51_14515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHF51_14520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NHF51_14525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_14535	COG2190	(PTS) system
NHF51_14540	COG3038	cytochrome b561
NHF51_14545	COG0419	ATPase involved in DNA repair
NHF51_14550	COG0420	3'-5' exonuclease activity
NHF51_14560	COG2974	May be involved in recombination
NHF51_14570	COG0405	Gamma-glutamyltransferase
NHF51_14575	COG4651	solute:proton antiporter activity
NHF51_14575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NHF51_14580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHF51_14585	COG1396	sequence-specific DNA binding
NHF51_14585	COG1917	Cupin 2, conserved barrel domain protein
NHF51_14600	COG0531	amino acid
NHF51_14605	COG0531	amino acid
NHF51_14615	COG1283	sodium-dependent phosphate transmembrane transporter activity
NHF51_14625	COG3384	dioxygenase
NHF51_14630	COG2205	protein histidine kinase activity
NHF51_14630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_14640	COG1566	PFAM secretion protein HlyD family protein
NHF51_14665	COG0784	Response regulator, receiver
NHF51_14665	COG2205	protein histidine kinase activity
NHF51_14680	COG1388	LysM domain
NHF51_14680	COG1376	ErfK ybiS ycfS ynhG family protein
NHF51_14695	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NHF51_14700	COG0791	NLP P60 protein
NHF51_14710	COG3118	belongs to the thioredoxin family
NHF51_14720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NHF51_14725	COG0788	formyltetrahydrofolate deformylase activity
NHF51_14755	COG0741	lytic transglycosylase activity
NHF51_14760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NHF51_14765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NHF51_14770	COG0673	inositol 2-dehydrogenase activity
NHF51_14795	COG1032	radical SAM domain protein
NHF51_14800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHF51_14810	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHF51_14815	COG0733	neurotransmitter:sodium symporter activity
NHF51_14840	COG2885	chlorophyll binding
NHF51_14840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NHF51_14845	COG0281	malic enzyme
NHF51_14855	COG0534	Mate efflux family protein
NHF51_14870	COG2233	PERMEase
NHF51_14875	COG0095	Lipoate-protein ligase
NHF51_14880	COG1115	amino acid carrier protein
NHF51_14885	COG0019	diaminopimelate decarboxylase activity
NHF51_14900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NHF51_14910	COG1126	abc transporter atp-binding protein
NHF51_14915	COG0765	amino acid transport
NHF51_14920	COG4597	amino acid ABC transporter
NHF51_14925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_14940	COG1131	(ABC) transporter
NHF51_14945	COG0545	Peptidyl-prolyl cis-trans isomerase
NHF51_14950	COG3142	Participates in the control of copper homeostasis
NHF51_14955	COG1940	carbohydrate kinase activity
NHF51_14975	COG5002	protein histidine kinase activity
NHF51_14980	COG0745	RESPONSE REGULATOR receiver
NHF51_14985	COG0346	lactoylglutathione lyase activity
NHF51_14995	COG3284	Transcriptional regulator
NHF51_15010	COG0697	spore germination
NHF51_15020	COG3290	protein histidine kinase activity
NHF51_15025	COG0281	malic enzyme
NHF51_15035	COG1846	Transcriptional regulator
NHF51_15040	COG1566	PFAM secretion protein HlyD family protein
NHF51_15070	COG0602	queuosine metabolic process
NHF51_15075	COG1328	CTP reductase activity
NHF51_15085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NHF51_15090	COG3115	cell septum assembly
NHF51_15095	COG1196	nuclear chromosome segregation
NHF51_15105	COG2860	membrane
NHF51_15115	COG3108	Peptidase M15
NHF51_15120	COG2989	Protein conserved in bacteria
NHF51_15135	COG0463	Glycosyl transferase, family 2
NHF51_15150	COG0366	Alpha amylase catalytic
NHF51_15190	COG3706	GGDEF domain
NHF51_15195	COG0037	tRNA processing
NHF51_15200	COG3590	peptidase
NHF51_15210	COG0488	(ABC) transporter
NHF51_15215	COG0531	amino acid
NHF51_15220	COG0814	amino acid
NHF51_15225	COG0583	DNA-binding transcription factor activity
NHF51_15235	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NHF51_15240	COG1982	Orn Lys Arg decarboxylase major
NHF51_15245	COG0531	amino acid
NHF51_15250	COG3710	Transcriptional regulator
NHF51_15255	COG0825	malonyl-CoA metabolic process
NHF51_15265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NHF51_15270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHF51_15275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHF51_15280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHF51_15285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHF51_15300	COG0750	zinc metalloprotease
NHF51_15305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NHF51_15310	COG0575	Belongs to the CDS family
NHF51_15315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NHF51_15320	COG0233	cytoplasmic translational termination
NHF51_15325	COG0528	UMP kinase activity
NHF51_15330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NHF51_15335	COG0052	Belongs to the universal ribosomal protein uS2 family
NHF51_15340	COG0024	Methionine aminopeptidase
NHF51_15345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NHF51_15350	COG2171	N-acyltransferase activity
NHF51_15360	COG1263	PTS System
NHF51_15360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_15370	COG4580	involved in the transport of maltose and maltodextrins
NHF51_15380	COG0564	pseudouridine synthase activity
NHF51_15385	COG3098	single-species biofilm formation
NHF51_15410	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NHF51_15420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NHF51_15420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NHF51_15435	COG1611	Belongs to the LOG family
NHF51_15440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHF51_15445	COG0473	3-isopropylmalate dehydrogenase activity
NHF51_15455	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NHF51_15460	COG2363	Small membrane protein
NHF51_15470	COG0583	DNA-binding transcription factor activity
NHF51_15475	COG0840	transmembrane signaling receptor activity
NHF51_15480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NHF51_15495	COG1477	protein flavinylation
NHF51_15500	COG2871	sodium ion transport
NHF51_15505	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NHF51_15510	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NHF51_15515	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NHF51_15520	COG1805	sodium ion transport
NHF51_15525	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NHF51_15530	COG0271	Belongs to the BolA IbaG family
NHF51_15535	COG2813	Specifically methylates the guanine in position
NHF51_15545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NHF51_15550	COG2211	Major facilitator Superfamily
NHF51_15560	COG1666	GTP binding
NHF51_15565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHF51_15580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHF51_15585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NHF51_15590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NHF51_15595	COG2188	Transcriptional regulator
NHF51_15600	COG1840	ABC-type Fe3 transport system, periplasmic component
NHF51_15605	COG3842	ATPase activity
NHF51_15615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHF51_15640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NHF51_15640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NHF51_15645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHF51_15650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHF51_15650	COG1017	nitric oxide dioxygenase activity
NHF51_15655	COG1151	hydroxylamine reductase activity
NHF51_15660	COG0783	Belongs to the Dps family
NHF51_15685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NHF51_15700	COG0300	oxidoreductase activity
NHF51_15710	COG0415	Belongs to the DNA photolyase family
NHF51_15715	COG0789	Transcriptional regulator
NHF51_15720	COG3272	Protein of unknown function (DUF1722)
NHF51_15745	COG1605	Chorismate mutase
NHF51_15745	COG0077	Prephenate dehydratase
NHF51_15770	COG3940	Belongs to the glycosyl hydrolase 43 family
NHF51_15775	COG2211	Major facilitator Superfamily
NHF51_15785	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHF51_15790	COG1129	ABC transporter
NHF51_15795	COG1879	ABC-type sugar transport system periplasmic component
NHF51_15800	COG1069	ribulokinase activity
NHF51_15810	COG2160	L-arabinose isomerase activity
NHF51_15815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHF51_15820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NHF51_15825	COG4580	involved in the transport of maltose and maltodextrins
NHF51_15830	COG3940	Belongs to the glycosyl hydrolase 43 family
NHF51_15835	COG3842	ATPase activity
NHF51_15840	COG0395	ABC-type sugar transport system, permease component
NHF51_15845	COG1175	transmembrane transport
NHF51_15860	COG1609	Transcriptional regulator
NHF51_15885	COG3254	rhamnose metabolic process
NHF51_15895	COG4806	L-rhamnose isomerase
NHF51_15900	COG1070	Carbohydrate kinase
NHF51_15910	COG1454	alcohol dehydrogenase
NHF51_15915	COG0235	Class ii aldolase
NHF51_15920	COG2133	pyrroloquinoline quinone binding
NHF51_15940	COG0300	oxidoreductase activity
NHF51_15965	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NHF51_15980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NHF51_15990	COG3813	Protein conserved in bacteria
NHF51_16000	COG0826	peptidase U32
NHF51_16010	COG1280	lysine exporter protein (LysE YggA)
NHF51_16020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHF51_16090	COG1566	PFAM secretion protein HlyD family protein
NHF51_16100	COG0114	fumarate hydratase activity
NHF51_16110	COG0506	proline dehydrogenase activity
NHF51_16110	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NHF51_16110	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NHF51_16115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHF51_16130	COG0737	Belongs to the 5'-nucleotidase family
NHF51_16155	COG0545	Peptidyl-prolyl cis-trans isomerase
NHF51_16170	COG1047	Peptidyl-prolyl cis-trans
NHF51_16175	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NHF51_16185	COG0835	chemotaxis
NHF51_16185	COG0784	Response regulator, receiver
NHF51_16190	COG0429	hydrolase of the alpha beta-hydrolase fold
NHF51_16195	COG2203	Gaf domain
NHF51_16195	COG3706	GGDEF domain
NHF51_16195	COG4251	negative regulation of phosphorylation
NHF51_16195	COG5001	Diguanylate cyclase
NHF51_16200	COG3089	Belongs to the UPF0270 family
NHF51_16205	COG3954	Phosphoribulokinase
NHF51_16220	COG1765	OsmC-like protein
NHF51_16250	COG2202	Pas domain
NHF51_16250	COG2205	protein histidine kinase activity
NHF51_16255	COG2814	Major facilitator Superfamily
NHF51_16280	COG0748	coenzyme F420 binding
NHF51_16285	COG3721	Heme iron utilization protein
NHF51_16295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHF51_16320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NHF51_16330	COG0463	Glycosyl transferase, family 2
NHF51_16335	COG0741	lytic transglycosylase activity
NHF51_16340	COG0488	(ABC) transporter
NHF51_16350	COG2252	PERMEase
NHF51_16355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NHF51_16360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NHF51_16365	COG3178	'Phosphotransferase
NHF51_16370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NHF51_16380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NHF51_16385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NHF51_16390	COG2967	ApaG domain
NHF51_16395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NHF51_16405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHF51_16410	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NHF51_16415	COG3314	Sporulation integral membrane protein YlbJ
NHF51_16420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NHF51_16425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NHF51_16430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NHF51_16435	COG0142	geranyltranstransferase activity
NHF51_16440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NHF51_16445	COG0330	HflC and HflK could
NHF51_16450	COG0330	HflC and HflK could
NHF51_16455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NHF51_16460	COG1923	regulation of RNA biosynthetic process
NHF51_16465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NHF51_16470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NHF51_16480	COG0802	atpase or kinase
NHF51_16485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NHF51_16485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NHF51_16490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NHF51_16505	COG2011	ABC-type metal ion transport system permease component
NHF51_16510	COG1464	Belongs to the NlpA lipoprotein family
NHF51_16545	COG0784	Response regulator, receiver
NHF51_16545	COG2198	Histidine kinase
NHF51_16545	COG5002	protein histidine kinase activity
NHF51_16565	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NHF51_16575	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_16580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NHF51_16585	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NHF51_16590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHF51_16595	COG2716	regulation of RNA biosynthetic process
NHF51_16600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NHF51_16605	COG3013	Belongs to the UPF0304 family
NHF51_16615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NHF51_16620	COG0280	phosphate acetyltransferase
NHF51_16620	COG0857	belongs to the CobB CobQ family
NHF51_16625	COG0440	acetolactate synthase activity
NHF51_16630	COG0028	Belongs to the TPP enzyme family
NHF51_16640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NHF51_16655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHF51_16660	COG0473	3-isopropylmalate dehydrogenase activity
NHF51_16665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NHF51_16670	COG0066	3-isopropylmalate dehydratase activity
NHF51_16690	COG1178	ABC-type Fe3 transport system permease component
NHF51_16695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NHF51_16700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NHF51_16740	COG0316	Belongs to the HesB IscA family
NHF51_16750	COG0038	chloride channel
NHF51_16755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NHF51_16770	COG0671	phosphoesterase, PA-phosphatase related
NHF51_16780	COG0583	DNA-binding transcription factor activity
NHF51_16785	COG2076	Multidrug Resistance protein
NHF51_16795	COG0346	lactoylglutathione lyase activity
NHF51_16800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHF51_16805	COG1643	Atp-dependent helicase
NHF51_16815	COG1489	DNA binding
NHF51_16820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NHF51_16825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHF51_16830	COG0617	tRNA 3'-terminal CCA addition
NHF51_16840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NHF51_16845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NHF51_16855	COG0842	Transport permease protein
NHF51_16860	COG1131	(ABC) transporter
NHF51_16875	COG0163	prenyltransferase activity
NHF51_16880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NHF51_16885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NHF51_16900	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NHF51_16915	COG1136	(ABC) transporter
NHF51_16955	COG0529	Catalyzes the synthesis of activated sulfate
NHF51_16960	COG3273	potassium ion transport
NHF51_16960	COG0471	metal ion transport
NHF51_16965	COG2895	sulfate adenylyltransferase (ATP) activity
NHF51_16970	COG0175	sulfate reduction
NHF51_16975	COG1648	precorrin-2 dehydrogenase activity
NHF51_16975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NHF51_16980	COG0330	HflC and HflK could
NHF51_16985	COG1585	Membrane protein implicated in regulation of membrane protease activity
NHF51_16995	COG0673	inositol 2-dehydrogenase activity
NHF51_17005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NHF51_17010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NHF51_17015	COG3036	rescue of stalled ribosome
NHF51_17030	COG0138	bifunctional purine biosynthesis protein purh
NHF51_17035	COG0151	Belongs to the GarS family
NHF51_17070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHF51_17075	COG0358	DNA primase activity
NHF51_17080	COG1610	YqeY-like protein
NHF51_17085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NHF51_17090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NHF51_17100	COG1388	LysM domain
NHF51_17100	COG4942	peptidase
NHF51_17105	COG1238	metal cluster binding
NHF51_17110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NHF51_17115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NHF51_17120	COG0585	pseudouridine synthase activity
NHF51_17130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NHF51_17135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NHF51_17140	COG0148	phosphopyruvate hydratase activity
NHF51_17145	COG0504	CTP synthase activity
NHF51_17150	COG3956	TIGRFAM MazG family protein
NHF51_17155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NHF51_17160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHF51_17170	COG4807	Protein conserved in bacteria
NHF51_17175	COG3023	N-Acetylmuramoyl-L-alanine amidase
NHF51_17180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NHF51_17185	COG1381	Involved in DNA repair and RecF pathway recombination
NHF51_17200	COG0681	Belongs to the peptidase S26 family
NHF51_17205	COG0481	GTPase activity
NHF51_17220	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NHF51_17225	COG1595	DNA-templated transcription, initiation
NHF51_17230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NHF51_17240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NHF51_17250	COG0583	DNA-binding transcription factor activity
NHF51_17270	COG4232	protein-disulfide reductase activity
NHF51_17290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHF51_17295	COG0191	fructose-bisphosphate aldolase activity
NHF51_17300	COG0126	phosphoglycerate kinase activity
NHF51_17305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NHF51_17310	COG1940	carbohydrate kinase activity
NHF51_17315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NHF51_17325	COG4991	sh3 domain protein
NHF51_17330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NHF51_17345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NHF51_17355	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_17370	COG1505	serine-type exopeptidase activity
NHF51_17375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NHF51_17380	COG0765	amino acid transport
NHF51_17385	COG0765	amino acid transport
NHF51_17390	COG1126	abc transporter atp-binding protein
NHF51_17395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHF51_17400	COG3174	membrane
NHF51_17405	COG0110	maltose O-acetyltransferase activity
NHF51_17430	COG0165	Argininosuccinate lyase
NHF51_17435	COG0137	argininosuccinate synthase activity
NHF51_17445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NHF51_17450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NHF51_17460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NHF51_17495	COG0583	DNA-binding transcription factor activity
NHF51_17500	COG1380	Effector of murein hydrolase LrgA
NHF51_17505	COG1346	cytolysis
NHF51_17510	COG0527	aspartate kinase activity
NHF51_17510	COG0460	homoserine dehydrogenase
NHF51_17515	COG0626	cystathionine gamma-synthase activity
NHF51_17530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHF51_17535	COG0814	amino acid
NHF51_17540	COG1218	3'(2'),5'-bisphosphate nucleotidase
NHF51_17545	COG0494	nUDIX hydrolase
NHF51_17550	COG1011	Hydrolase
NHF51_17555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHF51_17570	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NHF51_17580	COG3156	type II secretion system protein K
NHF51_17585	COG4795	General secretion pathway protein
NHF51_17590	COG2165	general secretion pathway protein
NHF51_17600	COG2165	general secretion pathway protein
NHF51_17605	COG1459	type II secretion system
NHF51_17610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHF51_17620	COG3031	protein transport across the cell outer membrane
NHF51_17630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NHF51_17635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NHF51_17655	COG0456	acetyltransferase
NHF51_17660	COG3133	Outer membrane lipoprotein
NHF51_17670	COG1392	Phosphate transport regulator
NHF51_17675	COG0306	phosphate transporter
NHF51_17680	COG0617	tRNA 3'-terminal CCA addition
NHF51_17685	COG3267	Type II secretory pathway component ExeA
NHF51_17685	COG3409	Peptidoglycan-binding domain 1 protein
NHF51_17695	COG1194	a g-specific adenine glycosylase
NHF51_17700	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NHF51_17715	COG3240	lipase activity
NHF51_17725	COG3009	Protein conserved in bacteria
NHF51_17730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NHF51_17730	COG3008	intermembrane lipid transfer
NHF51_17735	COG2995	paraquat-inducible protein a
NHF51_17745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHF51_17750	COG4251	negative regulation of phosphorylation
NHF51_17750	COG3706	GGDEF domain
NHF51_17750	COG2203	Gaf domain
NHF51_17750	COG5001	Diguanylate cyclase
NHF51_17755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHF51_17760	COG2813	Specifically methylates the guanine in position
NHF51_17765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NHF51_17770	COG0297	glycogen (starch) synthase activity
NHF51_17810	COG1757	Na H antiporter
NHF51_17815	COG0583	DNA-binding transcription factor activity
NHF51_17820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NHF51_17825	COG3842	ATPase activity
NHF51_17830	COG1176	ABC-type spermidine putrescine transport system, permease component I
NHF51_17835	COG1177	transmembrane transport
NHF51_17840	COG1012	belongs to the aldehyde dehydrogenase family
NHF51_17845	COG0109	protoheme IX farnesyltransferase activity
NHF51_17850	COG1612	heme a metabolic process
NHF51_17875	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NHF51_17880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHF51_17885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHF51_17890	COG1444	tRNA N-acetyltransferase activity
NHF51_17915	COG1803	Methylglyoxal synthase
NHF51_17930	COG0252	asparaginase activity
NHF51_17945	COG1609	Transcriptional regulator
NHF51_17950	COG1263	PTS System
NHF51_17950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHF51_17955	COG0366	Alpha amylase catalytic
NHF51_17960	COG0110	maltose O-acetyltransferase activity
NHF51_18000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NHF51_18005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NHF51_18020	COG0477	Major facilitator Superfamily
NHF51_18025	COG0523	cobalamin synthesis protein
NHF51_18035	COG1280	lysine exporter protein (LysE YggA)
NHF51_18045	COG2200	EAL domain
NHF51_18050	COG1049	propionate catabolic process, 2-methylcitrate cycle
NHF51_18055	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHF51_18060	COG0840	transmembrane signaling receptor activity
NHF51_18075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHF51_18080	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHF51_18085	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NHF51_18090	COG2186	Transcriptional regulator
NHF51_18115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHF51_18120	COG1459	type II secretion system
NHF51_18135	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NHF51_18140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NHF51_18145	COG0494	nUDIX hydrolase
NHF51_18155	COG0653	protein targeting
NHF51_18165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NHF51_18170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NHF51_18175	COG0849	cell division
NHF51_18180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NHF51_18185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NHF51_18190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NHF51_18195	COG0772	Belongs to the SEDS family
NHF51_18200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NHF51_18205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHF51_18210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NHF51_18215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NHF51_18220	COG0768	penicillin binding
NHF51_18225	COG3116	cell division
NHF51_18230	COG0275	rRNA processing
NHF51_18235	COG2001	Belongs to the MraZ family
NHF51_18245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NHF51_18250	COG3107	peptidoglycan biosynthetic process
NHF51_18255	COG0792	nuclease activity
NHF51_18260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NHF51_18265	COG2823	Periplasmic or secreted lipoprotein
NHF51_18270	COG2969	positive regulation of protein catabolic process
NHF51_18275	COG0625	glutathione transferase activity
NHF51_18280	COG2857	Cytochrome c1
NHF51_18285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHF51_18290	COG0723	plastoquinol--plastocyanin reductase activity
NHF51_18295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NHF51_18300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NHF51_18305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NHF51_18315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHF51_18320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHF51_18350	COG3964	amidohydrolase
NHF51_18370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_18375	COG1660	Displays ATPase and GTPase activities
NHF51_18380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHF51_18395	COG1137	ATPase activity
NHF51_18400	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NHF51_18405	COG3117	lipopolysaccharide transmembrane transporter activity
NHF51_18410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NHF51_18415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NHF51_18415	COG0517	IMP dehydrogenase activity
NHF51_18420	COG1127	ABC transporter
NHF51_18425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NHF51_18430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NHF51_18435	COG2854	intermembrane phospholipid transfer
NHF51_18445	COG5007	Belongs to the BolA IbaG family
NHF51_18450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NHF51_18455	COG0312	modulator of DNA gyrase
NHF51_18460	COG3028	Belongs to the UPF0307 family
NHF51_18470	COG2926	Belongs to the UPF0265 family
NHF51_18500	COG1396	sequence-specific DNA binding
NHF51_18505	COG3135	benzoate transporter
NHF51_18535	COG3047	cAMP biosynthetic process
NHF51_18545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NHF51_18550	COG2197	response regulator
NHF51_18555	COG0629	single-stranded DNA binding
NHF51_18570	COG1278	Cold shock
NHF51_18595	COG3706	GGDEF domain
NHF51_18605	COG0346	lactoylglutathione lyase activity
NHF51_18620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NHF51_18625	COG1074	ATP-dependent DNA helicase activity
NHF51_18630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NHF51_18635	COG2259	Doxx family
NHF51_18640	COG1741	Belongs to the pirin family
NHF51_18650	COG0583	DNA-binding transcription factor activity
NHF51_18685	COG3842	ATPase activity
NHF51_18695	COG3706	GGDEF domain
NHF51_18720	COG1247	-acetyltransferase
NHF51_18725	COG0753	catalase activity
NHF51_18745	COG0671	phosphoesterase, PA-phosphatase related
NHF51_18750	COG0628	permease
NHF51_18770	COG3284	Transcriptional regulator
NHF51_18780	COG1461	Dihydroxyacetone kinase
NHF51_18785	COG2376	Dihydroxyacetone kinase
NHF51_18790	COG2252	PERMEase
NHF51_18830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NHF51_18835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHF51_18840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NHF51_18845	COG0049	tRNA binding
NHF51_18850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NHF51_18855	COG2168	tRNA wobble position uridine thiolation
NHF51_18870	COG0251	oxidation-reduction process
NHF51_18875	COG2964	Protein conserved in bacteria
NHF51_18880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHF51_18885	COG0085	RNA polymerase activity
NHF51_18890	COG0222	ribosome binding
NHF51_18895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NHF51_18900	COG0081	regulation of translation
NHF51_18905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NHF51_18910	COG0250	Participates in transcription elongation, termination and antitermination
NHF51_18925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHF51_18950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NHF51_18955	COG0569	domain protein
NHF51_18960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHF51_18965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHF51_18970	COG3005	denitrification pathway
NHF51_18975	COG0243	molybdopterin cofactor binding
NHF51_19005	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NHF51_19020	COG2204	response regulator
NHF51_19030	COG2205	protein histidine kinase activity
NHF51_19045	COG1028	Short-chain dehydrogenase reductase Sdr
NHF51_19050	COG0517	IMP dehydrogenase activity
NHF51_19050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHF51_19050	COG0617	tRNA 3'-terminal CCA addition
NHF51_19055	COG5413	integral membrane protein
NHF51_19065	COG1522	sequence-specific DNA binding
NHF51_19070	COG2502	aspartate--ammonia ligase
NHF51_19075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NHF51_19080	COG0542	response to heat
NHF51_19090	COG0564	pseudouridine synthase activity
NHF51_19095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHF51_19100	COG0446	pyridine nucleotide-disulphide oxidoreductase
NHF51_19110	COG3681	Belongs to the UPF0597 family
NHF51_19115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NHF51_19120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NHF51_19130	COG1979	alcohol dehydrogenase
NHF51_19135	COG2207	Transcriptional regulator
NHF51_19170	COG0540	Belongs to the ATCase OTCase family
NHF51_19175	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NHF51_19180	COG1438	arginine binding
NHF51_19185	COG1288	antiporter activity
NHF51_19190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NHF51_19230	COG3250	beta-galactosidase activity
NHF51_19235	COG1609	Transcriptional regulator
NHF51_19240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHF51_19250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NHF51_19255	COG2017	converts alpha-aldose to the beta-anomer
NHF51_19260	COG0667	Aldo Keto reductase
NHF51_19265	COG1968	undecaprenyl-diphosphatase activity
NHF51_19275	COG1595	DNA-templated transcription, initiation
NHF51_19285	COG0018	arginyl-trna synthetase
NHF51_19295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NHF51_19300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NHF51_19315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHF51_19325	COG2116	formate transmembrane transporter activity
NHF51_19330	COG1648	precorrin-2 dehydrogenase activity
NHF51_19330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NHF51_19335	COG2239	Acts as a magnesium transporter
NHF51_19340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NHF51_19345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NHF51_19355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NHF51_19365	COG0514	ATP-dependent DNA helicase (RecQ)
NHF51_19370	COG2050	protein possibly involved in aromatic compounds catabolism
NHF51_19385	COG2258	MOSC domain
NHF51_19390	COG1177	transmembrane transport
NHF51_19395	COG1176	ABC-type spermidine putrescine transport system, permease component I
NHF51_19400	COG3842	ATPase activity
NHF51_19420	COG0174	glutamine synthetase
NHF51_19440	COG3045	CreA protein
NHF51_19445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHF51_19450	COG0443	Heat shock 70 kDa protein
NHF51_19465	COG0366	Alpha amylase catalytic
NHF51_19480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHF51_19485	COG0745	RESPONSE REGULATOR receiver
NHF51_19490	COG2205	protein histidine kinase activity
NHF51_19500	COG0281	malic enzyme
NHF51_19505	COG0702	epimerase
NHF51_19510	COG0254	rRNA binding
NHF51_19515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NHF51_19535	COG0129	dihydroxy-acid dehydratase activity
NHF51_19545	COG3978	acetolactate synthase activity
NHF51_19555	COG0606	chelatase, subunit chli
NHF51_19560	COG0204	Acyl-transferase
NHF51_19565	COG0204	Acyl-transferase
NHF51_19570	COG1683	Conserved Protein
NHF51_19585	COG1335	isochorismatase
NHF51_19595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NHF51_19600	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NHF51_19605	COG3639	organic phosphonate transmembrane transporter activity
NHF51_19610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NHF51_19615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NHF51_19625	COG3084	Protein conserved in bacteria
NHF51_19635	COG0789	Transcriptional regulator
NHF51_19645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NHF51_19650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NHF51_19655	COG1561	YicC-like family, N-terminal region
NHF51_19665	COG1519	Transferase
NHF51_19670	COG0859	PFAM glycosyl transferase family 9
NHF51_19675	COG0463	Glycosyl transferase, family 2
NHF51_19680	COG0859	PFAM glycosyl transferase family 9
NHF51_19685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NHF51_19690	COG2990	Protein conserved in bacteria
NHF51_19695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NHF51_19705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NHF51_19710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NHF51_19715	COG2003	Belongs to the UPF0758 family
NHF51_19720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NHF51_19725	COG0756	dUTP diphosphatase activity
NHF51_19730	COG1309	transcriptional regulator
NHF51_19735	COG0668	transmembrane transport
NHF51_19745	COG0166	Belongs to the GPI family
NHF51_19750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NHF51_19755	COG0583	DNA-binding transcription factor activity
NHF51_19795	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NHF51_19800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHF51_19805	COG1739	Uncharacterized protein family UPF0029
NHF51_19810	COG0006	proline dipeptidase activity
NHF51_19815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHF51_19820	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHF51_19820	COG1024	Enoyl-CoA hydratase
NHF51_19825	COG0183	Belongs to the thiolase family
NHF51_19840	COG1653	transport
NHF51_19855	COG0425	Belongs to the sulfur carrier protein TusA family
NHF51_19860	COG0251	oxidation-reduction process
NHF51_19865	COG2885	chlorophyll binding
NHF51_19885	COG2818	Glycosylase
NHF51_19890	COG0752	glycyl-tRNA synthetase alpha subunit
NHF51_19895	COG0751	glycine-tRNA ligase activity
NHF51_19920	COG0640	Transcriptional regulator
NHF51_19930	COG0814	amino acid
NHF51_19940	COG0814	amino acid
NHF51_19945	COG3033	Beta-eliminating lyase
NHF51_19950	COG0348	domain, Protein
NHF51_19960	COG0446	pyridine nucleotide-disulphide oxidoreductase
NHF51_19965	COG0426	domain, Protein
NHF51_19965	COG1773	rubredoxin
NHF51_19970	COG3604	Transcriptional regulator
NHF51_19975	COG1609	Transcriptional regulator
NHF51_19980	COG0683	leucine binding
NHF51_20015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHF51_20030	COG2960	long-chain fatty acid transporting porin activity
NHF51_20040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NHF51_20055	COG3118	belongs to the thioredoxin family
NHF51_20060	COG0513	Belongs to the DEAD box helicase family
NHF51_20065	COG0248	Ppx GppA phosphatase
NHF51_20080	COG0742	ribosomal rna small subunit methyltransferase
NHF51_20100	COG0084	hydrolase, TatD family'
NHF51_20105	COG0805	protein transport
NHF51_20110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHF51_20115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHF51_20120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NHF51_20135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHF51_20140	COG0402	S-adenosylhomocysteine deaminase activity
NHF51_20185	COG0848	biopolymer transport protein
NHF51_20190	COG0811	peptide transport
NHF51_20195	COG0811	peptide transport
NHF51_20205	COG2771	luxR family
NHF51_20215	COG1349	DNA-binding transcription factor activity
NHF51_20220	COG0745	RESPONSE REGULATOR receiver
NHF51_20225	COG2205	protein histidine kinase activity
NHF51_20235	COG4452	Inner membrane protein CreD
NHF51_20240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NHF51_20245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NHF51_20250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NHF51_20255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NHF51_20260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NHF51_20265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHF51_20270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NHF51_20280	COG0356	it plays a direct role in the translocation of protons across the membrane
NHF51_20290	COG1475	DNA binding
NHF51_20295	COG1192	Involved in chromosome partitioning
NHF51_20300	COG0357	Ribosomal RNA small subunit methyltransferase G
NHF51_20305	COG0445	tRNA wobble uridine modification
NHF51_20310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NHF51_20315	COG4774	siderophore transport
NHF51_20320	COG4615	Cyclic peptide transporter
NHF51_20325	COG1120	ATPase activity
NHF51_20330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHF51_20340	COG3550	peptidyl-serine autophosphorylation
NHF51_20395	COG4974	Belongs to the 'phage' integrase family
NHF51_20400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NHF51_20405	COG0706	membrane insertase activity
NHF51_20410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NHF51_20415	COG0594	ribonuclease P activity
NHF51_20420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NHF51_20425	COG1126	abc transporter atp-binding protein