locus-tag	class	description
K8O95_00010	COG0137	argininosuccinate synthase activity
K8O95_00015	COG0165	Argininosuccinate lyase
K8O95_00035	COG3314	Sporulation integral membrane protein YlbJ
K8O95_00040	COG0110	maltose O-acetyltransferase activity
K8O95_00065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8O95_00070	COG2022	thiamine diphosphate biosynthetic process
K8O95_00080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8O95_00085	COG0352	thiamine-phosphate diphosphorylase activity
K8O95_00090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K8O95_00110	COG0745	RESPONSE REGULATOR receiver
K8O95_00115	COG0642	Histidine kinase
K8O95_00120	COG0189	ligase activity
K8O95_00125	COG1410	methionine synthase
K8O95_00125	COG0646	methionine synthase
K8O95_00135	COG2200	EAL domain
K8O95_00140	COG2200	EAL domain
K8O95_00145	COG1049	propionate catabolic process, 2-methylcitrate cycle
K8O95_00150	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8O95_00155	COG0840	transmembrane signaling receptor activity
K8O95_00165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O95_00170	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O95_00175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K8O95_00180	COG2186	Transcriptional regulator
K8O95_00205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8O95_00210	COG1459	type II secretion system
K8O95_00215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K8O95_00225	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K8O95_00230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K8O95_00240	COG0653	protein targeting
K8O95_00250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K8O95_00255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K8O95_00260	COG0849	cell division
K8O95_00265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K8O95_00270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8O95_00275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8O95_00280	COG0772	Belongs to the SEDS family
K8O95_00285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8O95_00290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8O95_00295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8O95_00300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8O95_00305	COG0768	penicillin binding
K8O95_00310	COG3116	cell division
K8O95_00315	COG0275	rRNA processing
K8O95_00320	COG2001	Belongs to the MraZ family
K8O95_00330	COG0741	lytic transglycosylase activity
K8O95_00330	COG1388	LysM domain
K8O95_00345	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8O95_00350	COG1191	sigma factor activity
K8O95_00375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K8O95_00380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8O95_00400	COG4786	Flagellar basal body rod
K8O95_00400	COG1256	bacterial-type flagellum assembly
K8O95_00410	COG1706	bacterial-type flagellum-dependent cell motility
K8O95_00415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K8O95_00420	COG4786	Flagellar basal body rod
K8O95_00430	COG1749	Flagellar hook protein flgE
K8O95_00445	COG1815	bacterial-type flagellum-dependent cell motility
K8O95_00480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8O95_00490	COG1677	Flagellar hook-basal body complex protein FliE
K8O95_00515	COG1987	bacterial-type flagellum assembly
K8O95_00540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K8O95_00545	COG3107	peptidoglycan biosynthetic process
K8O95_00550	COG0792	nuclease activity
K8O95_00555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K8O95_00560	COG2823	Periplasmic or secreted lipoprotein
K8O95_00565	COG2969	positive regulation of protein catabolic process
K8O95_00570	COG0625	glutathione transferase activity
K8O95_00575	COG2857	Cytochrome c1
K8O95_00580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8O95_00585	COG0723	plastoquinol--plastocyanin reductase activity
K8O95_00590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K8O95_00595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K8O95_00600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K8O95_00610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O95_00615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O95_00620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_00625	COG1660	Displays ATPase and GTPase activities
K8O95_00630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_00640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K8O95_00645	COG1137	ATPase activity
K8O95_00650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K8O95_00655	COG3117	lipopolysaccharide transmembrane transporter activity
K8O95_00660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K8O95_00665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K8O95_00665	COG0517	IMP dehydrogenase activity
K8O95_00670	COG1127	ABC transporter
K8O95_00675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K8O95_00680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K8O95_00685	COG2854	intermembrane phospholipid transfer
K8O95_00695	COG5007	Belongs to the BolA IbaG family
K8O95_00700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K8O95_00705	COG0312	modulator of DNA gyrase
K8O95_00710	COG3028	Belongs to the UPF0307 family
K8O95_00715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K8O95_00725	COG0668	transmembrane transport
K8O95_00730	COG1011	Hydrolase
K8O95_00745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K8O95_00750	COG0019	diaminopimelate decarboxylase activity
K8O95_00760	COG1965	Belongs to the frataxin family
K8O95_00765	COG0400	carboxylic ester hydrolase activity
K8O95_00770	COG3072	Adenylate cyclase
K8O95_00775	COG0181	hydroxymethylbilane synthase activity
K8O95_00785	COG2959	enzyme of heme biosynthesis
K8O95_00800	COG1494	fructose-1,6-bisphosphatase
K8O95_00810	COG1686	Belongs to the peptidase S11 family
K8O95_00830	COG4974	Belongs to the 'phage' integrase family
K8O95_00905	COG4695	Portal protein
K8O95_00955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8O95_01050	COG0795	lipopolysaccharide-transporting ATPase activity
K8O95_01055	COG0795	lipopolysaccharide-transporting ATPase activity
K8O95_01060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O95_01065	COG2927	DNA polymerase III (CHI subunit)
K8O95_01085	COG1247	-acetyltransferase
K8O95_01090	COG0753	catalase activity
K8O95_01115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8O95_01135	COG4533	DNA binding
K8O95_01145	COG2873	o-acetylhomoserine
K8O95_01170	COG3842	ATPase activity
K8O95_01180	COG1175	transmembrane transport
K8O95_01205	COG3069	C4-dicarboxylate transmembrane transporter activity
K8O95_01220	COG0346	lactoylglutathione lyase activity
K8O95_01235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8O95_01240	COG1074	ATP-dependent DNA helicase activity
K8O95_01245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K8O95_01250	COG2259	Doxx family
K8O95_01255	COG1741	Belongs to the pirin family
K8O95_01265	COG0583	DNA-binding transcription factor activity
K8O95_01285	COG4771	TonB-dependent receptor
K8O95_01310	COG0203	ribosomal protein L17
K8O95_01315	COG0202	RNA polymerase activity
K8O95_01320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K8O95_01325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K8O95_01330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K8O95_01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8O95_01340	COG0201	protein transport
K8O95_01345	COG0200	Binds to the 23S rRNA
K8O95_01350	COG1841	ribosomal large subunit assembly
K8O95_01355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K8O95_01360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K8O95_01365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K8O95_01370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K8O95_01375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K8O95_01380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K8O95_01385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K8O95_01390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K8O95_01395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K8O95_01400	COG0255	Belongs to the universal ribosomal protein uL29 family
K8O95_01405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K8O95_01410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K8O95_01415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K8O95_01420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K8O95_01425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K8O95_01430	COG0089	rRNA binding
K8O95_01435	COG0088	Forms part of the polypeptide exit tunnel
K8O95_01440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K8O95_01445	COG0051	transcription antitermination factor activity, RNA binding
K8O95_01455	COG2205	protein histidine kinase activity
K8O95_01465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O95_01470	COG2183	response to ionizing radiation
K8O95_01490	COG0596	Alpha beta hydrolase
K8O95_01495	COG1040	competence protein
K8O95_01500	COG0316	Belongs to the HesB IscA family
K8O95_01500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K8O95_01505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K8O95_01510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K8O95_01520	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K8O95_01525	COG4942	peptidase
K8O95_01535	COG1609	Transcriptional regulator
K8O95_01540	COG0800	Aldolase
K8O95_01545	COG0129	dihydroxy-acid dehydratase activity
K8O95_01550	COG3265	gluconokinase activity
K8O95_01555	COG2610	gluconate transmembrane transporter activity
K8O95_01560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O95_01565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8O95_01575	COG0456	acetyltransferase
K8O95_01580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8O95_01585	COG1490	D-aminoacyl-tRNA deacylase activity
K8O95_01590	COG1295	ribonuclease BN
K8O95_01595	COG0281	malic enzyme
K8O95_01600	COG0702	epimerase
K8O95_01610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8O95_01615	COG0254	rRNA binding
K8O95_01625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K8O95_01630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K8O95_01640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K8O95_01650	COG0514	ATP-dependent DNA helicase (RecQ)
K8O95_01655	COG2050	protein possibly involved in aromatic compounds catabolism
K8O95_01670	COG2258	MOSC domain
K8O95_01675	COG1177	transmembrane transport
K8O95_01680	COG1176	ABC-type spermidine putrescine transport system, permease component I
K8O95_01685	COG3842	ATPase activity
K8O95_01705	COG0174	glutamine synthetase
K8O95_01720	COG3045	CreA protein
K8O95_01730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8O95_01735	COG0443	Heat shock 70 kDa protein
K8O95_01745	COG4310	Domain of unknown function (DUF2172)
K8O95_01760	COG0366	Alpha amylase catalytic
K8O95_01775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8O95_01795	COG3250	beta-galactosidase activity
K8O95_01800	COG1609	Transcriptional regulator
K8O95_01805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8O95_01810	COG1085	galactose-1-phosphate uridylyltransferase
K8O95_01815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K8O95_01820	COG2017	converts alpha-aldose to the beta-anomer
K8O95_01825	COG1968	undecaprenyl-diphosphatase activity
K8O95_01830	COG0018	arginyl-trna synthetase
K8O95_01840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K8O95_01845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K8O95_01855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_01860	COG1131	(ABC) transporter
K8O95_01865	COG0842	Transport permease protein
K8O95_01870	COG0842	Transport permease protein
K8O95_01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8O95_01890	COG2116	formate transmembrane transporter activity
K8O95_01895	COG1648	precorrin-2 dehydrogenase activity
K8O95_01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8O95_01900	COG2239	Acts as a magnesium transporter
K8O95_01910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K8O95_01915	COG2937	Belongs to the GPAT DAPAT family
K8O95_01920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K8O95_01925	COG3161	chorismate lyase activity
K8O95_01930	COG1580	Controls the rotational direction of flagella during chemotaxis
K8O95_01945	COG0604	alcohol dehydrogenase
K8O95_01950	COG1519	Transferase
K8O95_01955	COG0859	PFAM glycosyl transferase family 9
K8O95_01960	COG0463	Glycosyl transferase, family 2
K8O95_01965	COG0859	PFAM glycosyl transferase family 9
K8O95_01970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K8O95_01975	COG2990	Protein conserved in bacteria
K8O95_01980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K8O95_01990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K8O95_01995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K8O95_02000	COG2003	Belongs to the UPF0758 family
K8O95_02005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8O95_02010	COG0756	dUTP diphosphatase activity
K8O95_02015	COG1309	transcriptional regulator
K8O95_02020	COG0668	transmembrane transport
K8O95_02025	COG0166	Belongs to the GPI family
K8O95_02030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K8O95_02080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8O95_02090	COG0583	DNA-binding transcription factor activity
K8O95_02105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K8O95_02110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K8O95_02115	COG2223	nitrite transmembrane transporter activity
K8O95_02120	COG3279	Response regulator of the LytR AlgR family
K8O95_02125	COG3275	phosphorelay sensor kinase activity
K8O95_02135	COG2081	HI0933 family
K8O95_02140	COG1528	Iron-storage protein
K8O95_02145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8O95_02150	COG0589	response to stress
K8O95_02190	COG3642	lipopolysaccharide core region biosynthetic process
K8O95_02195	COG0859	PFAM glycosyl transferase family 9
K8O95_02205	COG1758	RNA polymerase activity
K8O95_02210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8O95_02215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8O95_02225	COG2267	carboxylic ester hydrolase activity
K8O95_02230	COG0561	phosphatase activity
K8O95_02260	COG2271	Major facilitator Superfamily
K8O95_02265	COG0469	pyruvate kinase activity
K8O95_02295	COG1309	transcriptional regulator
K8O95_02300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_02305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_02315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K8O95_02330	COG3118	belongs to the thioredoxin family
K8O95_02335	COG0513	Belongs to the DEAD box helicase family
K8O95_02340	COG0248	Ppx GppA phosphatase
K8O95_02355	COG0742	ribosomal rna small subunit methyltransferase
K8O95_02375	COG0084	hydrolase, TatD family'
K8O95_02380	COG0805	protein transport
K8O95_02385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8O95_02395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K8O95_02400	COG3165	ubiquinone biosynthetic process from chorismate
K8O95_02410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K8O95_02415	COG0402	S-adenosylhomocysteine deaminase activity
K8O95_02420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K8O95_02460	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K8O95_02465	COG0848	biopolymer transport protein
K8O95_02470	COG0811	peptide transport
K8O95_02475	COG0811	peptide transport
K8O95_02485	COG2771	luxR family
K8O95_02495	COG1349	DNA-binding transcription factor activity
K8O95_02500	COG0745	RESPONSE REGULATOR receiver
K8O95_02505	COG2205	protein histidine kinase activity
K8O95_02510	COG4452	Inner membrane protein CreD
K8O95_02515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K8O95_02520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K8O95_02525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K8O95_02530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K8O95_02535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K8O95_02540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8O95_02545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8O95_02555	COG0356	it plays a direct role in the translocation of protons across the membrane
K8O95_02565	COG1475	DNA binding
K8O95_02570	COG1192	Involved in chromosome partitioning
K8O95_02575	COG0357	Ribosomal RNA small subunit methyltransferase G
K8O95_02580	COG0445	tRNA wobble uridine modification
K8O95_02585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8O95_02590	COG4774	siderophore transport
K8O95_02595	COG4615	Cyclic peptide transporter
K8O95_02600	COG1120	ATPase activity
K8O95_02605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8O95_02620	COG1902	pentaerythritol trinitrate reductase activity
K8O95_02625	COG1280	lysine exporter protein (LysE YggA)
K8O95_02630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K8O95_02635	COG0706	membrane insertase activity
K8O95_02640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K8O95_02645	COG0594	ribonuclease P activity
K8O95_02650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K8O95_02655	COG1126	abc transporter atp-binding protein
K8O95_02670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K8O95_02675	COG0592	DNA-directed DNA polymerase activity
K8O95_02690	COG0071	Belongs to the small heat shock protein (HSP20) family
K8O95_02695	COG0071	Belongs to the small heat shock protein (HSP20) family
K8O95_02700	COG3977	Valine--pyruvate aminotransferase
K8O95_02715	COG2814	Major facilitator Superfamily
K8O95_02720	COG0745	RESPONSE REGULATOR receiver
K8O95_02725	COG2205	protein histidine kinase activity
K8O95_02750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O95_02760	COG2960	long-chain fatty acid transporting porin activity
K8O95_02775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8O95_02810	COG0683	leucine binding
K8O95_02815	COG1609	Transcriptional regulator
K8O95_02820	COG0348	domain, Protein
K8O95_02825	COG0814	amino acid
K8O95_02855	COG0751	glycine-tRNA ligase activity
K8O95_02860	COG0752	glycyl-tRNA synthetase alpha subunit
K8O95_02865	COG2818	Glycosylase
K8O95_02870	COG2885	chlorophyll binding
K8O95_02875	COG0251	oxidation-reduction process
K8O95_02880	COG0425	Belongs to the sulfur carrier protein TusA family
K8O95_02905	COG0183	Belongs to the thiolase family
K8O95_02910	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8O95_02910	COG1024	Enoyl-CoA hydratase
K8O95_02915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8O95_02920	COG0006	proline dipeptidase activity
K8O95_02925	COG1739	Uncharacterized protein family UPF0029
K8O95_02930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8O95_02935	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K8O95_02965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8O95_02970	COG2166	iron-sulfur cluster assembly
K8O95_02975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8O95_02990	COG3245	cytochrome
K8O95_02995	COG1063	alcohol dehydrogenase
K8O95_03000	COG0156	8-amino-7-oxononanoate synthase activity
K8O95_03010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8O95_03025	COG3306	glycosyltransferase involved in LPS biosynthesis
K8O95_03090	COG0210	DNA helicase
K8O95_03095	COG1744	ABC transporter substrate-binding protein PnrA-like
K8O95_03100	COG3845	ABC transporter
K8O95_03105	COG4603	Belongs to the binding-protein-dependent transport system permease family
K8O95_03110	COG1079	Belongs to the binding-protein-dependent transport system permease family
K8O95_03120	COG0534	Mate efflux family protein
K8O95_03125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K8O95_03130	COG2205	protein histidine kinase activity
K8O95_03135	COG0745	RESPONSE REGULATOR receiver
K8O95_03145	COG1045	serine acetyltransferase
K8O95_03155	COG3074	FtsZ-dependent cytokinesis
K8O95_03160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K8O95_03165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O95_03165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O95_03170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8O95_03205	COG1609	Transcriptional regulator
K8O95_03210	COG3250	beta-galactosidase activity
K8O95_03215	COG2731	YhcH YjgK YiaL family protein
K8O95_03220	COG0531	amino acid
K8O95_03225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O95_03230	COG0531	amino acid
K8O95_03235	COG0385	Bile acid
K8O95_03240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K8O95_03260	COG0583	DNA-binding transcription factor activity
K8O95_03265	COG1561	YicC-like family, N-terminal region
K8O95_03270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K8O95_03275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8O95_03285	COG0789	Transcriptional regulator
K8O95_03290	COG3706	GGDEF domain
K8O95_03290	COG4251	negative regulation of phosphorylation
K8O95_03290	COG5001	Diguanylate cyclase
K8O95_03290	COG2203	Gaf domain
K8O95_03295	COG3084	Protein conserved in bacteria
K8O95_03305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8O95_03310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8O95_03315	COG3639	organic phosphonate transmembrane transporter activity
K8O95_03320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K8O95_03325	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K8O95_03335	COG1335	isochorismatase
K8O95_03345	COG1683	Conserved Protein
K8O95_03350	COG0204	Acyl-transferase
K8O95_03355	COG0204	Acyl-transferase
K8O95_03360	COG0606	chelatase, subunit chli
K8O95_03370	COG3978	acetolactate synthase activity
K8O95_03380	COG0129	dihydroxy-acid dehydratase activity
K8O95_03395	COG1309	transcriptional regulator
K8O95_03405	COG2391	methyltransferase activity
K8O95_03410	COG1280	lysine exporter protein (LysE YggA)
K8O95_03420	COG2962	Rard protein
K8O95_03430	COG1012	belongs to the aldehyde dehydrogenase family
K8O95_03435	COG1396	sequence-specific DNA binding
K8O95_03440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8O95_03450	COG0519	Catalyzes the synthesis of GMP from XMP
K8O95_03450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8O95_03460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O95_03490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K8O95_03495	COG2204	response regulator
K8O95_03500	COG3852	Histidine kinase
K8O95_03510	COG0174	glutamine synthetase
K8O95_03515	COG1217	gtp-binding protein TYPA
K8O95_03520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8O95_03525	COG0569	domain protein
K8O95_03530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O95_03530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8O95_03535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8O95_03540	COG0242	peptide deformylase activity
K8O95_03545	COG1652	LysM domain
K8O95_03550	COG0758	DNA mediated transformation
K8O95_03555	COG2922	Belongs to the Smg family
K8O95_03560	COG0551	DNA topoisomerase type I activity
K8O95_03565	COG0009	L-threonylcarbamoyladenylate synthase
K8O95_03570	COG0408	coproporphyrinogen oxidase activity
K8O95_03575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K8O95_03585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K8O95_03595	COG3078	GTPase activator activity
K8O95_03605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8O95_03635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K8O95_03640	COG1288	antiporter activity
K8O95_03645	COG1438	arginine binding
K8O95_03650	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K8O95_03655	COG0540	Belongs to the ATCase OTCase family
K8O95_03675	COG3040	lipid binding
K8O95_03680	COG2207	Transcriptional regulator
K8O95_03685	COG1979	alcohol dehydrogenase
K8O95_03690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K8O95_03695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K8O95_03700	COG3681	Belongs to the UPF0597 family
K8O95_03710	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8O95_03715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O95_03720	COG0564	pseudouridine synthase activity
K8O95_03730	COG0542	response to heat
K8O95_03735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K8O95_03740	COG2502	aspartate--ammonia ligase
K8O95_03745	COG1522	sequence-specific DNA binding
K8O95_03755	COG5413	integral membrane protein
K8O95_03760	COG0517	IMP dehydrogenase activity
K8O95_03760	COG0617	tRNA 3'-terminal CCA addition
K8O95_03760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8O95_03765	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_03780	COG2205	protein histidine kinase activity
K8O95_03790	COG2204	response regulator
K8O95_03840	COG0243	molybdopterin cofactor binding
K8O95_03845	COG3005	denitrification pathway
K8O95_03850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O95_03850	COG4191	Histidine kinase
K8O95_03860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8O95_03880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8O95_03885	COG0569	domain protein
K8O95_03890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K8O95_03920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O95_03935	COG0250	Participates in transcription elongation, termination and antitermination
K8O95_03940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K8O95_03945	COG0081	regulation of translation
K8O95_03950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K8O95_03955	COG0222	ribosome binding
K8O95_03960	COG0085	RNA polymerase activity
K8O95_03965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K8O95_03970	COG2964	Protein conserved in bacteria
K8O95_03990	COG2168	tRNA wobble position uridine thiolation
K8O95_03995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K8O95_04000	COG0049	tRNA binding
K8O95_04005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8O95_04010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O95_04015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K8O95_04060	COG3714	YhhN family
K8O95_04085	COG1301	dicarboxylic acid transport
K8O95_04095	COG2095	MarC family integral membrane protein
K8O95_04105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8O95_04115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K8O95_04120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O95_04135	COG1770	oligopeptidase
K8O95_04150	COG4221	oxidoreductase activity
K8O95_04155	COG0583	DNA-binding transcription factor activity
K8O95_04160	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8O95_04185	COG0742	ribosomal rna small subunit methyltransferase
K8O95_04190	COG0552	protein localization to endoplasmic reticulum
K8O95_04195	COG2884	Cell division ATP-binding protein ftsE
K8O95_04200	COG2177	Part of the ABC transporter FtsEX involved in
K8O95_04210	COG0288	reversible hydration of carbon dioxide
K8O95_04220	COG3314	Sporulation integral membrane protein YlbJ
K8O95_04225	COG1228	amidohydrolase
K8O95_04230	COG0010	Belongs to the arginase family
K8O95_04235	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K8O95_04240	COG2986	histidine ammonia-lyase
K8O95_04245	COG0387	Pfam Sodium calcium exchanger
K8O95_04250	COG2200	EAL domain
K8O95_04260	COG2199	diguanylate cyclase activity
K8O95_04260	COG2200	EAL domain
K8O95_04305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8O95_04310	COG1459	type II secretion system
K8O95_04320	COG2165	general secretion pathway protein
K8O95_04355	COG1077	Cell shape determining protein MreB Mrl
K8O95_04360	COG1792	Involved in formation and maintenance of cell shape
K8O95_04365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K8O95_04370	COG0424	maF-like protein
K8O95_04375	COG1530	ribonuclease E activity
K8O95_04380	COG3164	Protein of unknown function
K8O95_04385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8O95_04390	COG0312	modulator of DNA gyrase
K8O95_04405	COG0477	Major facilitator Superfamily
K8O95_04445	COG0523	cobalamin synthesis protein
K8O95_04450	COG0477	Major facilitator Superfamily
K8O95_04470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K8O95_04475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K8O95_04500	COG2203	Gaf domain
K8O95_04500	COG2199	diguanylate cyclase activity
K8O95_04520	COG0814	amino acid
K8O95_04525	COG3932	Exopolysaccharide synthesis, ExoD
K8O95_04535	COG1733	regulation of RNA biosynthetic process
K8O95_04545	COG0004	ammonium transporteR
K8O95_04550	COG3133	Outer membrane lipoprotein
K8O95_04555	COG0456	acetyltransferase
K8O95_04575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K8O95_04580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K8O95_04600	COG0628	permease
K8O95_04615	COG3284	Transcriptional regulator
K8O95_04625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_04625	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K8O95_04625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O95_04630	COG1461	Dihydroxyacetone kinase
K8O95_04635	COG2376	Dihydroxyacetone kinase
K8O95_04640	COG2252	PERMEase
K8O95_04645	COG1278	Cold shock
K8O95_04650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8O95_04665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K8O95_04680	COG0840	transmembrane signaling receptor activity
K8O95_04700	COG3135	benzoate transporter
K8O95_04705	COG1396	sequence-specific DNA binding
K8O95_04755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8O95_04755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8O95_04770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K8O95_04775	COG0038	chloride channel
K8O95_04785	COG0316	Belongs to the HesB IscA family
K8O95_04790	COG1757	Na H antiporter
K8O95_04830	COG0297	glycogen (starch) synthase activity
K8O95_04835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K8O95_04840	COG2813	Specifically methylates the guanine in position
K8O95_04845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8O95_04855	COG1392	Phosphate transport regulator
K8O95_04860	COG0306	phosphate transporter
K8O95_04865	COG0460	homoserine dehydrogenase
K8O95_04865	COG0527	aspartate kinase activity
K8O95_04870	COG0626	cystathionine gamma-synthase activity
K8O95_04880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O95_04885	COG0814	amino acid
K8O95_04890	COG1218	3'(2'),5'-bisphosphate nucleotidase
K8O95_04895	COG0494	nUDIX hydrolase
K8O95_04900	COG1011	Hydrolase
K8O95_04915	COG0110	maltose O-acetyltransferase activity
K8O95_04920	COG3174	membrane
K8O95_04925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K8O95_04935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K8O95_04940	COG4208	sulfate ABC transporter
K8O95_04945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K8O95_04950	COG0583	DNA-binding transcription factor activity
K8O95_04955	COG3397	chitin binding
K8O95_04960	COG0840	transmembrane signaling receptor activity
K8O95_04970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8O95_04975	COG1215	transferase activity, transferring glycosyl groups
K8O95_04980	COG1215	transferase activity, transferring glycosyl groups
K8O95_04985	COG4783	chaperone-mediated protein folding
K8O95_05005	COG1215	transferase activity, transferring glycosyl groups
K8O95_05020	COG0726	polysaccharide deacetylase
K8O95_05020	COG1649	PFAM Uncharacterised BCR, COG1649
K8O95_05025	COG1215	transferase activity, transferring glycosyl groups
K8O95_05080	COG0628	permease
K8O95_05095	COG1328	CTP reductase activity
K8O95_05100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8O95_05115	COG1448	Aminotransferase
K8O95_05130	COG1840	ABC-type Fe3 transport system, periplasmic component
K8O95_05140	COG3842	ATPase activity
K8O95_05145	COG2837	iron assimilation
K8O95_05150	COG1438	arginine binding
K8O95_05155	COG1126	abc transporter atp-binding protein
K8O95_05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O95_05165	COG4215	(ABC) transporter
K8O95_05170	COG4160	amino acid transport
K8O95_05175	COG0039	L-malate dehydrogenase activity
K8O95_05180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K8O95_05185	COG1017	nitric oxide dioxygenase activity
K8O95_05185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8O95_05195	COG4536	flavin adenine dinucleotide binding
K8O95_05200	COG4137	Cytochrome C assembly protein
K8O95_05205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8O95_05210	COG0228	four-way junction DNA binding
K8O95_05215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K8O95_05220	COG0336	Belongs to the RNA methyltransferase TrmD family
K8O95_05225	COG0335	large ribosomal subunit rRNA binding
K8O95_05235	COG3066	DNA modification
K8O95_05240	COG1051	belongs to the nudix hydrolase family
K8O95_05250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K8O95_05255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K8O95_05280	COG0513	Belongs to the DEAD box helicase family
K8O95_05295	COG3112	Uncharacterised protein family (UPF0231)
K8O95_05300	COG3835	regulator
K8O95_05305	COG2610	gluconate transmembrane transporter activity
K8O95_05310	COG1929	Belongs to the glycerate kinase type-1 family
K8O95_05325	COG0583	DNA-binding transcription factor activity
K8O95_05330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8O95_05340	COG1872	DUF167
K8O95_05345	COG0762	integral membrane protein
K8O95_05350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8O95_05355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K8O95_05370	COG3022	response to hydroperoxide
K8O95_05390	COG0347	Belongs to the P(II) protein family
K8O95_05410	COG0617	tRNA 3'-terminal CCA addition
K8O95_05415	COG1194	a g-specific adenine glycosylase
K8O95_05420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K8O95_05430	COG3111	PFAM Bacterial OB fold (BOF) protein
K8O95_05435	COG3240	lipase activity
K8O95_05445	COG3706	GGDEF domain
K8O95_05450	COG0557	exoribonuclease II activity
K8O95_05455	COG1204	response to ionizing radiation
K8O95_05465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8O95_05475	COG2153	protein acetylation
K8O95_05480	COG0513	Belongs to the DEAD box helicase family
K8O95_05485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K8O95_05505	COG0735	belongs to the Fur family
K8O95_05510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8O95_05515	COG0840	transmembrane signaling receptor activity
K8O95_05525	COG4166	transmembrane transport
K8O95_05535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K8O95_05540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K8O95_05545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K8O95_05550	COG2204	response regulator
K8O95_05565	COG1024	Enoyl-CoA hydratase
K8O95_05580	COG4221	oxidoreductase activity
K8O95_05585	COG0442	prolyl-tRNA aminoacylation
K8O95_05590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8O95_05595	COG3009	Protein conserved in bacteria
K8O95_05600	COG3008	intermembrane lipid transfer
K8O95_05600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K8O95_05605	COG2995	paraquat-inducible protein a
K8O95_05615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_05625	COG2203	Gaf domain
K8O95_05625	COG3706	GGDEF domain
K8O95_05625	COG4251	negative regulation of phosphorylation
K8O95_05625	COG5001	Diguanylate cyclase
K8O95_05630	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K8O95_05645	COG2771	luxR family
K8O95_05660	COG0840	transmembrane signaling receptor activity
K8O95_05665	COG0632	four-way junction helicase activity
K8O95_05670	COG2255	four-way junction helicase activity
K8O95_05680	COG1294	oxidase, subunit
K8O95_05685	COG4890	Cyd operon protein YbgT
K8O95_05690	COG3790	cyd operon protein YbgE
K8O95_05695	COG0824	Thioesterase
K8O95_05700	COG0811	peptide transport
K8O95_05715	COG0823	Involved in the tonB-independent uptake of proteins
K8O95_05720	COG2885	chlorophyll binding
K8O95_05725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K8O95_05790	COG0733	neurotransmitter:sodium symporter activity
K8O95_05800	COG0733	neurotransmitter:sodium symporter activity
K8O95_05815	COG0561	phosphatase activity
K8O95_05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O95_05855	COG0358	DNA primase activity
K8O95_05860	COG1610	YqeY-like protein
K8O95_05865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K8O95_05870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K8O95_05875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K8O95_05880	COG1027	Aspartate ammonia-lyase
K8O95_05885	COG3030	protein affecting phage T7 exclusion by the F plasmid
K8O95_05890	COG0534	Mate efflux family protein
K8O95_05895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K8O95_05900	COG0459	protein refolding
K8O95_05950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K8O95_05955	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K8O95_05960	COG1178	ABC-type Fe3 transport system permease component
K8O95_05965	COG4143	(ABC) transporter
K8O95_05980	COG0066	3-isopropylmalate dehydratase activity
K8O95_05985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K8O95_05990	COG0473	3-isopropylmalate dehydrogenase activity
K8O95_05995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8O95_06020	COG0028	Belongs to the TPP enzyme family
K8O95_06025	COG0440	acetolactate synthase activity
K8O95_06060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K8O95_06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_06105	COG0745	RESPONSE REGULATOR receiver
K8O95_06110	COG3104	oligopeptide transport
K8O95_06115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8O95_06120	COG1555	photosystem II stabilization
K8O95_06125	COG0857	belongs to the CobB CobQ family
K8O95_06125	COG0280	phosphate acetyltransferase
K8O95_06130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K8O95_06140	COG3013	Belongs to the UPF0304 family
K8O95_06145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8O95_06150	COG2716	regulation of RNA biosynthetic process
K8O95_06155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8O95_06160	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K8O95_06165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K8O95_06190	COG2198	Histidine kinase
K8O95_06190	COG0784	Response regulator, receiver
K8O95_06190	COG5002	protein histidine kinase activity
K8O95_06205	COG2205	protein histidine kinase activity
K8O95_06205	COG0784	Response regulator, receiver
K8O95_06215	COG0250	Participates in transcription elongation, termination and antitermination
K8O95_06220	COG1464	Belongs to the NlpA lipoprotein family
K8O95_06225	COG2011	ABC-type metal ion transport system permease component
K8O95_06230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8O95_06250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K8O95_06250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K8O95_06255	COG0802	atpase or kinase
K8O95_06265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K8O95_06270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8O95_06275	COG1923	regulation of RNA biosynthetic process
K8O95_06280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8O95_06285	COG0330	HflC and HflK could
K8O95_06290	COG0330	HflC and HflK could
K8O95_06295	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K8O95_06300	COG0142	geranyltranstransferase activity
K8O95_06305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K8O95_06310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K8O95_06315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K8O95_06320	COG3314	Sporulation integral membrane protein YlbJ
K8O95_06325	COG0318	PFAM AMP-dependent synthetase and ligase
K8O95_06330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K8O95_06335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8O95_06345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K8O95_06350	COG2967	ApaG domain
K8O95_06355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8O95_06360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K8O95_06370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K8O95_06380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8O95_06385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K8O95_06390	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8O95_06395	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K8O95_06400	COG1073	alpha beta
K8O95_06410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K8O95_06415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K8O95_06425	COG4628	conserved protein (DUF2132)
K8O95_06430	COG0688	phosphatidylethanolamine metabolic process
K8O95_06440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K8O95_06480	COG1278	Cold shock
K8O95_06490	COG0840	transmembrane signaling receptor activity
K8O95_06495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O95_06505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8O95_06510	COG4991	sh3 domain protein
K8O95_06520	COG2816	NAD+ diphosphatase activity
K8O95_06525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K8O95_06530	COG1940	carbohydrate kinase activity
K8O95_06535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8O95_06540	COG0126	phosphoglycerate kinase activity
K8O95_06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O95_06595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K8O95_06605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K8O95_06610	COG1595	DNA-templated transcription, initiation
K8O95_06615	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
K8O95_06620	COG3026	antisigma factor binding
K8O95_06630	COG0481	GTPase activity
K8O95_06635	COG0681	Belongs to the peptidase S26 family
K8O95_06640	COG0571	ribonuclease III activity
K8O95_06650	COG1381	Involved in DNA repair and RecF pathway recombination
K8O95_06655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K8O95_06675	COG2350	Protein conserved in bacteria
K8O95_06680	COG2917	probably involved in intracellular septation
K8O95_06685	COG0076	glutamate decarboxylase activity
K8O95_06690	COG1272	protein, Hemolysin III
K8O95_06695	COG0569	domain protein
K8O95_06695	COG2985	domain, Protein
K8O95_06710	COG3300	MHYT domain
K8O95_06710	COG5001	Diguanylate cyclase
K8O95_06715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
K8O95_06735	COG1858	cytochrome C peroxidase
K8O95_06745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8O95_06750	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_06795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O95_06810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O95_06845	COG2313	pseudouridylate synthase activity
K8O95_06850	COG1522	sequence-specific DNA binding
K8O95_06850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O95_06890	COG1765	OsmC-like protein
K8O95_06905	COG3954	Phosphoribulokinase
K8O95_06910	COG3089	Belongs to the UPF0270 family
K8O95_06915	COG0429	hydrolase of the alpha beta-hydrolase fold
K8O95_06920	COG0784	Response regulator, receiver
K8O95_06920	COG0835	chemotaxis
K8O95_06930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
K8O95_06935	COG1047	Peptidyl-prolyl cis-trans
K8O95_06950	COG0545	Peptidyl-prolyl cis-trans isomerase
K8O95_06955	COG2204	response regulator
K8O95_06975	COG0737	Belongs to the 5'-nucleotidase family
K8O95_06990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8O95_07015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8O95_07025	COG3721	Heme iron utilization protein
K8O95_07030	COG0748	coenzyme F420 binding
K8O95_07075	COG2814	Major facilitator Superfamily
K8O95_07080	COG2205	protein histidine kinase activity
K8O95_07125	COG0835	chemotaxis
K8O95_07125	COG0784	Response regulator, receiver
K8O95_07130	COG2755	lipolytic protein G-D-S-L family
K8O95_07135	COG4181	ATPase activity
K8O95_07140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K8O95_07145	COG1090	epimerase
K8O95_07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8O95_07155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K8O95_07160	COG3171	Protein conserved in bacteria
K8O95_07165	COG2066	Belongs to the glutaminase family
K8O95_07170	COG2897	thiosulfate sulfurtransferase activity
K8O95_07175	COG1404	Belongs to the peptidase S8 family
K8O95_07190	COG0521	Mo-molybdopterin cofactor biosynthetic process
K8O95_07200	COG2966	Psort location CytoplasmicMembrane, score
K8O95_07215	COG4175	Glycine betaine
K8O95_07220	COG4176	ABC-type proline glycine betaine transport system permease component
K8O95_07225	COG2113	Glycine betaine
K8O95_07230	COG0175	sulfate reduction
K8O95_07235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8O95_07240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8O95_07245	COG0384	phenazine biosynthesis protein PhzF
K8O95_07250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K8O95_07265	COG0786	glutamate:sodium symporter activity
K8O95_07270	COG0252	asparaginase activity
K8O95_07275	COG3139	Protein of unknown function (DUF1315)
K8O95_07295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K8O95_07300	COG0321	lipoyl(octanoyl) transferase activity
K8O95_07305	COG2921	Belongs to the UPF0250 family
K8O95_07310	COG1686	Belongs to the peptidase S11 family
K8O95_07315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K8O95_07320	COG2951	lytic endotransglycosylase activity
K8O95_07325	COG0772	Belongs to the SEDS family
K8O95_07330	COG0768	penicillin binding
K8O95_07335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K8O95_07340	COG0799	negative regulation of ribosome biogenesis
K8O95_07345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K8O95_07360	COG0495	leucyl-tRNA aminoacylation
K8O95_07365	COG2888	peptidyl-tyrosine sulfation
K8O95_07370	COG0312	modulator of DNA gyrase
K8O95_07385	COG4974	Belongs to the 'phage' integrase family
K8O95_07395	COG1970	mechanosensitive ion channel activity
K8O95_07410	COG0789	Transcriptional regulator
K8O95_07420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K8O95_07425	COG4535	Mg2 and Co2 transporter CorC
K8O95_07430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K8O95_07435	COG1702	phosphate starvation-inducible protein PhoH
K8O95_07440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8O95_07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O95_07465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_07470	COG2199	diguanylate cyclase activity
K8O95_07485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8O95_07495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K8O95_07505	COG0516	GMP reductase activity
K8O95_07510	COG0189	ligase activity
K8O95_07510	COG4067	protein conserved in archaea
K8O95_07515	COG0642	Histidine kinase
K8O95_07530	COG0300	oxidoreductase activity
K8O95_07555	COG3214	Protein conserved in bacteria
K8O95_07565	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8O95_07570	COG0700	Nucleoside recognition
K8O95_07575	COG3366	ferrous iron transmembrane transporter activity
K8O95_07585	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K8O95_07590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K8O95_07595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K8O95_07600	COG1053	succinate dehydrogenase
K8O95_07610	COG0584	glycerophosphoryl diester phosphodiesterase
K8O95_07615	COG3264	Mechanosensitive ion channel
K8O95_07615	COG1511	domain protein
K8O95_07625	COG0739	heme binding
K8O95_07635	COG0583	DNA-binding transcription factor activity
K8O95_07655	COG0583	DNA-binding transcription factor activity
K8O95_07660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8O95_07690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K8O95_07695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K8O95_07705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K8O95_07710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K8O95_07720	COG0180	Tryptophanyl-tRNA synthetase
K8O95_07735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8O95_07745	COG1012	belongs to the aldehyde dehydrogenase family
K8O95_07760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_07775	COG0488	(ABC) transporter
K8O95_07785	COG0443	Heat shock 70 kDa protein
K8O95_07790	COG2214	Heat shock protein DnaJ domain protein
K8O95_07800	COG0657	acetylesterase activity
K8O95_07815	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K8O95_07825	COG0471	metal ion transport
K8O95_07825	COG0490	domain, Protein
K8O95_07870	COG0012	GTP binding
K8O95_07875	COG0193	aminoacyl-tRNA hydrolase activity
K8O95_07880	COG0737	Belongs to the 5'-nucleotidase family
K8O95_07885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K8O95_07895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K8O95_07900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K8O95_07905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K8O95_07910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K8O95_07915	COG2890	protein-(glutamine-N5) methyltransferase activity
K8O95_07925	COG2912	Transglutaminase-like superfamily
K8O95_07930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K8O95_07940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K8O95_07955	COG1881	PFAM PEBP family protein
K8O95_07960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K8O95_07975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8O95_07985	COG0583	DNA-binding transcription factor activity
K8O95_07990	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_07995	COG0616	signal peptide processing
K8O95_08000	COG2211	Major facilitator Superfamily
K8O95_08005	COG3706	GGDEF domain
K8O95_08010	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K8O95_08020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O95_08025	COG0826	peptidase U32
K8O95_08050	COG3724	N-succinylarginine dihydrolase activity
K8O95_08070	COG0840	transmembrane signaling receptor activity
K8O95_08080	COG2971	BadF BadG BcrA BcrD
K8O95_08090	COG4608	Belongs to the ABC transporter superfamily
K8O95_08095	COG0444	Belongs to the ABC transporter superfamily
K8O95_08100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8O95_08105	COG0601	transmembrane transport
K8O95_08115	COG2205	protein histidine kinase activity
K8O95_08115	COG0784	Response regulator, receiver
K8O95_08155	COG3220	belongs to the UPF0276 family
K8O95_08185	COG1289	transmembrane transporter activity
K8O95_08190	COG0303	'Molybdopterin
K8O95_08195	COG0746	molybdenum cofactor guanylyltransferase activity
K8O95_08205	COG4662	Binding-protein-dependent transport system inner membrane component
K8O95_08215	COG2204	response regulator
K8O95_08220	COG3852	Histidine kinase
K8O95_08225	COG1910	domain protein
K8O95_08230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K8O95_08265	COG3383	formate dehydrogenase (NAD+) activity
K8O95_08265	COG3383	formate dehydrogenase (NAD+) activity
K8O95_08270	COG0437	4 iron, 4 sulfur cluster binding
K8O95_08280	COG0281	malic enzyme
K8O95_08295	COG2233	PERMEase
K8O95_08310	COG0837	glucose binding
K8O95_08315	COG1737	Transcriptional regulator
K8O95_08320	COG0469	pyruvate kinase activity
K8O95_08335	COG1677	Flagellar hook-basal body complex protein FliE
K8O95_08345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8O95_08400	COG1684	flagellar biosynthetic protein fliR
K8O95_08410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8O95_08435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K8O95_08440	COG0643	Histidine kinase
K8O95_08440	COG0784	Response regulator, receiver
K8O95_08440	COG2198	Histidine kinase
K8O95_08445	COG2201	protein-glutamate methylesterase activity
K8O95_08450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8O95_08455	COG1360	Flagellar Motor Protein
K8O95_08460	COG1192	Involved in chromosome partitioning
K8O95_08470	COG0835	chemotaxis
K8O95_08480	COG4133	protoheme IX ABC transporter activity
K8O95_08485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8O95_08490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8O95_08495	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8O95_08500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K8O95_08505	COG1138	Cytochrome C-type biogenesis protein
K8O95_08510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O95_08535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K8O95_08540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O95_08540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8O95_08555	COG0259	pyridoxamine-phosphate oxidase activity
K8O95_08560	COG0625	glutathione transferase activity
K8O95_08565	COG3153	acetyltransferase
K8O95_08575	COG2850	peptidyl-arginine hydroxylation
K8O95_08580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K8O95_08585	COG2915	High frequency lysogenization protein hflD homolog
K8O95_08590	COG0482	sulfurtransferase activity
K8O95_08600	COG1187	pseudouridine synthase activity
K8O95_08610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_08620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_08620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_08620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_08635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8O95_08655	COG1342	Belongs to the UPF0251 family
K8O95_08670	COG1309	transcriptional regulator
K8O95_08675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_08680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_08690	COG1091	dTDP-4-dehydrorhamnose reductase activity
K8O95_08710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8O95_08725	COG0028	Belongs to the TPP enzyme family
K8O95_08745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8O95_08765	COG0438	transferase activity, transferring glycosyl groups
K8O95_08770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8O95_08780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
K8O95_08790	COG2916	Histone family protein nucleoid-structuring protein H-NS
K8O95_08800	COG1136	(ABC) transporter
K8O95_08800	COG0577	efflux transmembrane transporter activity
K8O95_08805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_08815	COG0497	DNA recombination
K8O95_08820	COG1486	melibiose metabolic process
K8O95_08825	COG0583	DNA-binding transcription factor activity
K8O95_08830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K8O95_08835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K8O95_08840	COG0443	Heat shock 70 kDa protein
K8O95_08845	COG0484	heat shock protein binding
K8O95_08850	COG1285	pathogenesis
K8O95_08865	COG0640	Transcriptional regulator
K8O95_08895	COG0095	Lipoate-protein ligase
K8O95_08905	COG0702	epimerase
K8O95_08910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O95_08915	COG1454	alcohol dehydrogenase
K8O95_08955	COG1280	lysine exporter protein (LysE YggA)
K8O95_08960	COG3263	regulation of cellular component size
K8O95_08970	COG3263	regulation of cellular component size
K8O95_08985	COG1876	peptidase activity
K8O95_08990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8O95_08995	COG1393	Belongs to the ArsC family
K8O95_09005	COG3069	C4-dicarboxylate transmembrane transporter activity
K8O95_09010	COG1473	amidohydrolase
K8O95_09020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K8O95_09025	COG0017	Asparaginyl-tRNA synthetase
K8O95_09045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8O95_09050	COG0156	8-amino-7-oxononanoate synthase activity
K8O95_09055	COG1073	alpha beta
K8O95_09055	COG2226	methyltransferase
K8O95_09060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K8O95_09065	COG0501	Belongs to the peptidase M48B family
K8O95_09075	COG0633	Ferredoxin
K8O95_09075	COG3217	Mosc domain protein beta barrel domain protein
K8O95_09075	COG3217	Mosc domain protein beta barrel domain protein
K8O95_09075	COG0633	Ferredoxin
K8O95_09085	COG0674	pyruvate-flavodoxin oxidoreductase activity
K8O95_09085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K8O95_09085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K8O95_09085	COG1013	pyruvate-flavodoxin oxidoreductase activity
K8O95_09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8O95_09100	COG1607	acyl-coa hydrolase
K8O95_09110	COG3021	interspecies interaction between organisms
K8O95_09125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K8O95_09130	COG2027	D-alanyl-D-alanine carboxypeptidase
K8O95_09135	COG1061	Type III restriction enzyme res subunit
K8O95_09140	COG1566	PFAM secretion protein HlyD family protein
K8O95_09150	COG1966	Carbon starvation protein
K8O95_09155	COG3279	Response regulator of the LytR AlgR family
K8O95_09160	COG3275	phosphorelay sensor kinase activity
K8O95_09170	COG2194	sulfuric ester hydrolase activity
K8O95_09175	COG1846	Transcriptional regulator
K8O95_09175	COG1940	carbohydrate kinase activity
K8O95_09180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K8O95_09185	COG0363	glucosamine-6-phosphate deaminase activity
K8O95_09190	COG1263	PTS System
K8O95_09190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_09190	COG2190	(PTS) system
K8O95_09200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O95_09205	COG0735	belongs to the Fur family
K8O95_09215	COG0716	FMN binding
K8O95_09230	COG0596	Alpha beta hydrolase
K8O95_09235	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K8O95_09240	COG0033	Phosphoglucomutase
K8O95_09255	COG2951	lytic endotransglycosylase activity
K8O95_09260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K8O95_09265	COG4136	ATPase activity
K8O95_09270	COG4135	transport system, permease component
K8O95_09275	COG4134	Bacterial extracellular solute-binding protein
K8O95_09280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O95_09285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K8O95_09300	COG0583	DNA-binding transcription factor activity
K8O95_09305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8O95_09315	COG0729	surface antigen
K8O95_09320	COG2911	Protein conserved in bacteria
K8O95_09340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K8O95_09360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K8O95_09365	COG4771	TonB-dependent receptor
K8O95_09370	COG1169	isochorismate synthase
K8O95_09375	COG1021	2,3-dihydroxybenzoate-AMP ligase
K8O95_09380	COG1535	isochorismatase
K8O95_09380	COG3433	isochorismatase activity
K8O95_09385	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_09390	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K8O95_09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8O95_09415	COG1278	Cold shock
K8O95_09440	COG4166	transmembrane transport
K8O95_09450	COG1349	DNA-binding transcription factor activity
K8O95_09455	COG1882	Formate acetyltransferase
K8O95_09460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8O95_09465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8O95_09475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K8O95_09490	COG4166	transmembrane transport
K8O95_09495	COG0622	Phosphoesterase
K8O95_09510	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
K8O95_09515	COG0835	chemotaxis
K8O95_09515	COG0784	Response regulator, receiver
K8O95_09520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8O95_09525	COG1815	bacterial-type flagellum-dependent cell motility
K8O95_09545	COG4787	bacterial-type flagellum-dependent cell motility
K8O95_09555	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K8O95_09560	COG1706	bacterial-type flagellum-dependent cell motility
K8O95_09565	COG3951	Flagellar rod assembly protein muramidase FlgJ
K8O95_09565	COG1705	Flagellar rod assembly protein muramidase FlgJ
K8O95_09580	COG2239	Acts as a magnesium transporter
K8O95_09590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K8O95_09595	COG2716	regulation of RNA biosynthetic process
K8O95_09620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K8O95_09625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8O95_09630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K8O95_09635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K8O95_09655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K8O95_09670	COG0590	tRNA wobble adenosine to inosine editing
K8O95_09675	COG0573	inorganic phosphate transmembrane transporter activity
K8O95_09680	COG0581	inorganic phosphate transmembrane transporter activity
K8O95_09685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8O95_09690	COG0704	Plays a role in the regulation of phosphate uptake
K8O95_09695	COG1253	flavin adenine dinucleotide binding
K8O95_09720	COG0765	amino acid transport
K8O95_09725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O95_09730	COG2271	Major facilitator Superfamily
K8O95_09740	COG2197	response regulator
K8O95_09745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O95_09765	COG1785	Belongs to the alkaline phosphatase family
K8O95_09770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K8O95_09775	COG0477	Major facilitator Superfamily
K8O95_09780	COG0123	including yeast histone deacetylase and acetoin utilization protein
K8O95_09790	COG1199	ATP-dependent helicase activity
K8O95_09800	COG1605	Chorismate mutase
K8O95_09800	COG0287	Prephenate dehydrogenase
K8O95_09805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K8O95_09815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8O95_09820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8O95_09855	COG0537	adenosine 5'-monophosphoramidase activity
K8O95_09875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8O95_09890	COG1301	dicarboxylic acid transport
K8O95_09895	COG1733	regulation of RNA biosynthetic process
K8O95_09910	COG2354	Protein conserved in bacteria
K8O95_09920	COG2233	PERMEase
K8O95_09930	COG1252	NADH dehydrogenase
K8O95_09950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8O95_09955	COG3300	MHYT domain
K8O95_09955	COG5001	Diguanylate cyclase
K8O95_09960	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8O95_09970	COG2373	Large extracellular alpha-helical protein
K8O95_09975	COG4953	penicillin-binding protein 1C
K8O95_09985	COG0301	tRNA thio-modification
K8O95_09985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8O95_10000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8O95_10010	COG1334	flagellar protein FlaG
K8O95_10045	COG2089	acid synthase
K8O95_10055	COG1083	cytidylyl-transferase
K8O95_10075	COG0318	PFAM AMP-dependent synthetase and ligase
K8O95_10090	COG1216	Glycosyl transferase, family 2
K8O95_10095	COG1442	glycosyl transferase family 8
K8O95_10105	COG1216	Glycosyl transferase, family 2
K8O95_10110	COG0463	Glycosyl transferase, family 2
K8O95_10115	COG2226	methyltransferase
K8O95_10145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8O95_10150	COG1086	Polysaccharide biosynthesis protein
K8O95_10155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8O95_10165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K8O95_10190	COG0625	glutathione transferase activity
K8O95_10195	COG2814	Major facilitator Superfamily
K8O95_10200	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O95_10210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K8O95_10215	COG0215	cysteine-tRNA ligase activity
K8O95_10260	COG2119	membrane
K8O95_10265	COG0023	Translation Initiation Factor
K8O95_10275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8O95_10290	COG0513	Belongs to the DEAD box helicase family
K8O95_10295	COG0493	'glutamate synthase
K8O95_10300	COG0070	glutamate synthase
K8O95_10300	COG0069	glutamate synthase activity
K8O95_10300	COG0067	glutamate synthase
K8O95_10305	COG1242	4 iron, 4 sulfur cluster binding
K8O95_10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_10360	COG3634	alkyl hydroperoxide reductase activity
K8O95_10370	COG0517	IMP dehydrogenase activity
K8O95_10375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K8O95_10380	COG0343	queuine tRNA-ribosyltransferase activity
K8O95_10385	COG1862	Preprotein translocase
K8O95_10390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8O95_10395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8O95_10410	COG0826	peptidase U32
K8O95_10415	COG0826	peptidase U32
K8O95_10420	COG3154	lipid carrier protein
K8O95_10435	COG1959	2 iron, 2 sulfur cluster binding
K8O95_10440	COG1104	cysteine desulfurase activity
K8O95_10445	COG0822	iron-sulfur transferase activity
K8O95_10455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K8O95_10460	COG0443	Heat shock 70 kDa protein
K8O95_10465	COG0633	Ferredoxin
K8O95_10475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O95_10480	COG0105	UTP biosynthetic process
K8O95_10485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K8O95_10495	COG1426	Protein conserved in bacteria
K8O95_10500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K8O95_10505	COG0124	histidyl-tRNA synthetase
K8O95_10510	COG2976	Protein conserved in bacteria
K8O95_10515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O95_10520	COG1160	GTP binding
K8O95_10525	COG1645	bacterial-type flagellum-dependent swarming motility
K8O95_10535	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K8O95_10540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8O95_10540	COG0047	phosphoribosylformylglycinamidine synthase activity
K8O95_10550	COG2056	Na+-H+ antiporter family
K8O95_10555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K8O95_10560	COG0671	phosphoesterase, PA-phosphatase related
K8O95_10565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8O95_10570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8O95_10580	COG0101	tRNA pseudouridine synthase activity
K8O95_10585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K8O95_10590	COG0285	dihydrofolate synthase activity
K8O95_10595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K8O95_10600	COG0393	Putative heavy-metal-binding
K8O95_10605	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8O95_10610	COG1368	sulfuric ester hydrolase activity
K8O95_10620	COG0527	aspartate kinase activity
K8O95_10625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K8O95_10625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K8O95_10630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8O95_10650	COG0596	Alpha beta hydrolase
K8O95_10655	COG0346	lactoylglutathione lyase activity
K8O95_10665	COG0583	DNA-binding transcription factor activity
K8O95_10670	COG1620	l-lactate permease
K8O95_10675	COG0247	lactate metabolic process
K8O95_10680	COG1139	Iron-sulfur cluster binding protein
K8O95_10705	COG0577	efflux transmembrane transporter activity
K8O95_10730	COG2814	Major facilitator Superfamily
K8O95_10755	COG0672	)-iron permease
K8O95_10780	COG0659	secondary active sulfate transmembrane transporter activity
K8O95_10870	COG0583	DNA-binding transcription factor activity
K8O95_10875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8O95_10880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K8O95_10885	COG0539	negative regulation of cytoplasmic translation
K8O95_10890	COG0776	regulation of translation
K8O95_10900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K8O95_10920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K8O95_10925	COG0602	queuosine metabolic process
K8O95_10930	COG3530	Putative quorum-sensing-regulated virulence factor
K8O95_10935	COG2096	Adenosyltransferase
K8O95_10940	COG2916	Histone family protein nucleoid-structuring protein H-NS
K8O95_10945	COG1757	Na H antiporter
K8O95_10950	COG1435	thymidine kinase activity
K8O95_10970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8O95_10975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K8O95_10980	COG0326	Molecular chaperone. Has ATPase activity
K8O95_10985	COG4172	Belongs to the ABC transporter superfamily
K8O95_10995	COG4171	peptide transport system, permease
K8O95_11000	COG4168	peptide transport system, permease
K8O95_11005	COG0747	negative chemotaxis
K8O95_11010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K8O95_11015	COG1842	Phage shock protein A
K8O95_11030	COG3106	COG3106 Predicted ATPase
K8O95_11035	COG3768	UPF0283 membrane protein
K8O95_11040	COG0583	DNA-binding transcription factor activity
K8O95_11045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K8O95_11050	COG3842	ATPase activity
K8O95_11055	COG1176	ABC-type spermidine putrescine transport system, permease component I
K8O95_11060	COG1177	transmembrane transport
K8O95_11065	COG1012	belongs to the aldehyde dehydrogenase family
K8O95_11075	COG2154	pterin-4-alpha-carbinolamine dehydratase
K8O95_11095	COG2199	diguanylate cyclase activity
K8O95_11100	COG2885	chlorophyll binding
K8O95_11105	COG0861	Integral membrane protein TerC family
K8O95_11120	COG1022	Amp-dependent synthetase and ligase
K8O95_11145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K8O95_11150	COG1278	Cold shock
K8O95_11155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K8O95_11160	COG0542	response to heat
K8O95_11165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K8O95_11170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K8O95_11175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K8O95_11180	COG3134	Outer membrane lipoprotein
K8O95_11185	COG3706	GGDEF domain
K8O95_11190	COG0492	ferredoxin-NADP+ reductase activity
K8O95_11195	COG0686	Belongs to the AlaDH PNT family
K8O95_11205	COG0531	amino acid
K8O95_11205	COG1674	ftsk spoiiie
K8O95_11210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K8O95_11215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8O95_11220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K8O95_11225	COG1286	toxin biosynthetic process
K8O95_11230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K8O95_11240	COG0563	adenylate kinase activity
K8O95_11245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K8O95_11255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O95_11260	COG0840	transmembrane signaling receptor activity
K8O95_11275	COG5001	Diguanylate cyclase
K8O95_11275	COG3300	MHYT domain
K8O95_11325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K8O95_11330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K8O95_11335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K8O95_11350	COG0513	Belongs to the DEAD box helicase family
K8O95_11355	COG0386	Belongs to the glutathione peroxidase family
K8O95_11365	COG1181	Belongs to the D-alanine--D-alanine ligase family
K8O95_11370	COG1570	exodeoxyribonuclease VII activity
K8O95_11375	COG2200	EAL domain
K8O95_11380	COG0516	GMP reductase activity
K8O95_11380	COG0517	IMP dehydrogenase activity
K8O95_11385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8O95_11385	COG0519	Catalyzes the synthesis of GMP from XMP
K8O95_11405	COG0500	methyltransferase
K8O95_11415	COG2062	phosphohistidine phosphatase, SixA
K8O95_11425	COG0697	spore germination
K8O95_11430	COG4166	transmembrane transport
K8O95_11435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K8O95_11440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8O95_11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
K8O95_11455	COG1136	(ABC) transporter
K8O95_11460	COG4591	ABC-type transport system involved in lipoprotein release permease component
K8O95_11465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K8O95_11475	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8O95_11480	COG0740	serine-type endopeptidase activity
K8O95_11485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K8O95_11490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K8O95_11495	COG0776	regulation of translation
K8O95_11500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8O95_11505	COG0488	(ABC) transporter
K8O95_11535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8O95_11540	COG3162	membrane
K8O95_11555	COG1024	Enoyl-CoA hydratase
K8O95_11560	COG1115	amino acid carrier protein
K8O95_11575	COG1584	GPR1 FUN34 yaaH family protein
K8O95_11605	COG1024	Enoyl-CoA hydratase
K8O95_11605	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8O95_11610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8O95_11615	COG1960	acyl-CoA dehydrogenase activity
K8O95_11620	COG1960	acyl-CoA dehydrogenase activity
K8O95_11625	COG1024	Enoyl-CoA hydratase
K8O95_11630	COG1024	Enoyl-CoA hydratase
K8O95_11640	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_11650	COG0730	response to heat
K8O95_11670	COG0667	Aldo Keto reductase
K8O95_11680	COG2205	protein histidine kinase activity
K8O95_11680	COG0784	Response regulator, receiver
K8O95_11720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8O95_11730	COG0438	transferase activity, transferring glycosyl groups
K8O95_11810	COG0438	transferase activity, transferring glycosyl groups
K8O95_11815	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
K8O95_11820	COG0437	4 iron, 4 sulfur cluster binding
K8O95_11825	COG5557	Pfam Polysulphide reductase, NrfD
K8O95_11830	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
K8O95_11835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K8O95_11840	COG1773	rubredoxin
K8O95_11845	COG0747	negative chemotaxis
K8O95_11855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8O95_11865	COG3842	ATPase activity
K8O95_11870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K8O95_11875	COG0375	protein maturation
K8O95_11880	COG0309	Hydrogenase expression formation protein (HypE)
K8O95_11890	COG0298	carbon dioxide binding
K8O95_11895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
K8O95_11905	COG1921	L-seryl-tRNASec selenium transferase activity
K8O95_11915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K8O95_11925	COG3260	NADH ubiquinone oxidoreductase 20
K8O95_11930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_11935	COG3261	NADH dehydrogenase
K8O95_11935	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
K8O95_11940	COG0650	Formate hydrogenlyase subunit 4
K8O95_11945	COG0651	ATP synthesis coupled electron transport
K8O95_11950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O95_11970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O95_11995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8O95_12000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O95_12005	COG0295	cytidine deaminase activity
K8O95_12010	COG1346	cytolysis
K8O95_12015	COG1380	Effector of murein hydrolase LrgA
K8O95_12020	COG3345	alpha-galactosidase
K8O95_12030	COG2925	Exonuclease
K8O95_12040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8O95_12045	COG0436	Aminotransferase
K8O95_12050	COG0583	DNA-binding transcription factor activity
K8O95_12055	COG0617	tRNA 3'-terminal CCA addition
K8O95_12055	COG0517	IMP dehydrogenase activity
K8O95_12055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8O95_12060	COG1643	Atp-dependent helicase
K8O95_12070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K8O95_12085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K8O95_12090	COG2067	long-chain fatty acid transport protein
K8O95_12095	COG2067	long-chain fatty acid transport protein
K8O95_12105	COG1595	DNA-templated transcription, initiation
K8O95_12115	COG2304	oxidoreductase activity
K8O95_12135	COG0714	Associated with various cellular activities
K8O95_12140	COG0183	Belongs to the thiolase family
K8O95_12145	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8O95_12145	COG1024	Enoyl-CoA hydratase
K8O95_12150	COG2719	SpoVR family
K8O95_12155	COG2718	Belongs to the UPF0229 family
K8O95_12160	COG2766	serine protein kinase
K8O95_12165	COG0514	ATP-dependent DNA helicase (RecQ)
K8O95_12170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K8O95_12175	COG0814	amino acid
K8O95_12180	COG0494	nUDIX hydrolase
K8O95_12200	COG0140	phosphoribosyl-ATP diphosphatase activity
K8O95_12200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K8O95_12205	COG0107	imidazoleglycerol-phosphate synthase activity
K8O95_12210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K8O95_12215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K8O95_12220	COG0131	Imidazoleglycerol-phosphate dehydratase
K8O95_12220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K8O95_12225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K8O95_12230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K8O95_12235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K8O95_12245	COG1199	ATP-dependent helicase activity
K8O95_12250	COG1214	PFAM Peptidase M22, glycoprotease
K8O95_12260	COG0596	Alpha beta hydrolase
K8O95_12265	COG0318	PFAM AMP-dependent synthetase and ligase
K8O95_12275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O95_12280	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K8O95_12285	COG0709	Synthesizes selenophosphate from selenide and ATP
K8O95_12300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8O95_12310	COG1254	Belongs to the acylphosphatase family
K8O95_12315	COG0625	glutathione transferase activity
K8O95_12320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O95_12320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O95_12325	COG0489	protein tyrosine kinase activity
K8O95_12330	COG0572	uridine kinase
K8O95_12335	COG0717	Belongs to the dCTP deaminase family
K8O95_12340	COG0306	phosphate transporter
K8O95_12345	COG1530	ribonuclease E activity
K8O95_12360	COG0424	maF-like protein
K8O95_12365	COG1399	metal-binding, possibly nucleic acid-binding protein
K8O95_12370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K8O95_12375	COG0416	fatty acid biosynthetic process
K8O95_12380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O95_12390	COG1028	Short-chain dehydrogenase reductase Sdr
K8O95_12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O95_12405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8O95_12410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8O95_12415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K8O95_12420	COG0470	DNA polymerase III
K8O95_12425	COG0084	hydrolase, TatD family'
K8O95_12440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8O95_12440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K8O95_12445	COG3008	intermembrane lipid transfer
K8O95_12450	COG2995	paraquat-inducible protein a
K8O95_12460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K8O95_12465	COG0372	Belongs to the citrate synthase family
K8O95_12510	COG4221	oxidoreductase activity
K8O95_12520	COG3141	response to X-ray
K8O95_12540	COG1067	ATP-dependent peptidase activity
K8O95_12545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O95_12555	COG0488	(ABC) transporter
K8O95_12565	COG0116	Belongs to the methyltransferase superfamily
K8O95_12565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8O95_12570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8O95_12575	COG0254	rRNA binding
K8O95_12595	COG3290	protein histidine kinase activity
K8O95_12595	COG0840	transmembrane signaling receptor activity
K8O95_12605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8O95_12610	COG2201	protein-glutamate methylesterase activity
K8O95_12615	COG2203	Gaf domain
K8O95_12615	COG3706	GGDEF domain
K8O95_12615	COG5001	Diguanylate cyclase
K8O95_12615	COG4251	negative regulation of phosphorylation
K8O95_12625	COG0167	dihydroorotate dehydrogenase activity
K8O95_12630	COG2902	Dehydrogenase
K8O95_12640	COG0308	aminopeptidase N
K8O95_12645	COG0793	Belongs to the peptidase S41A family
K8O95_12650	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K8O95_12655	COG1956	GAF domain-containing protein
K8O95_12665	COG3278	Belongs to the heme-copper respiratory oxidase family
K8O95_12680	COG2010	Cytochrome c
K8O95_12705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8O95_12710	COG0589	response to stress
K8O95_12715	COG0037	tRNA processing
K8O95_12740	COG1177	transmembrane transport
K8O95_12750	COG2194	sulfuric ester hydrolase activity
K8O95_12755	COG1869	D-ribose catabolic process
K8O95_12760	COG1129	ABC transporter
K8O95_12765	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8O95_12770	COG1879	ABC-type sugar transport system periplasmic component
K8O95_12775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O95_12780	COG1609	Transcriptional regulator
K8O95_12785	COG5001	Diguanylate cyclase
K8O95_12785	COG3300	MHYT domain
K8O95_12810	COG0784	Response regulator, receiver
K8O95_12810	COG2205	protein histidine kinase activity
K8O95_12815	COG0776	regulation of translation
K8O95_12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O95_12820	COG0072	phenylalanine-tRNA ligase activity
K8O95_12825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K8O95_12830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K8O95_12835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K8O95_12840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K8O95_12845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8O95_12865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8O95_12875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8O95_12880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8O95_12885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8O95_12890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K8O95_12895	COG3313	Fe-S protein
K8O95_12900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_12900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_12900	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K8O95_12905	COG1105	Belongs to the carbohydrate kinase PfkB family
K8O95_12910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_12910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_12915	COG1609	Transcriptional regulator
K8O95_12920	COG0814	amino acid
K8O95_12925	COG0513	Belongs to the DEAD box helicase family
K8O95_12930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K8O95_12935	COG2890	protein-(glutamine-N5) methyltransferase activity
K8O95_12940	COG2840	Smr protein MutS2
K8O95_12950	COG3706	GGDEF domain
K8O95_12965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8O95_12980	COG2824	Alkylphosphonate utilization operon protein PhnA
K8O95_12985	COG3706	GGDEF domain
K8O95_12990	COG0318	PFAM AMP-dependent synthetase and ligase
K8O95_12995	COG1288	antiporter activity
K8O95_13005	COG3134	Outer membrane lipoprotein
K8O95_13010	COG2080	2 iron, 2 sulfur cluster binding
K8O95_13015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K8O95_13020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K8O95_13025	COG2252	PERMEase
K8O95_13030	COG0402	S-adenosylhomocysteine deaminase activity
K8O95_13035	COG2233	PERMEase
K8O95_13040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K8O95_13040	COG2080	2 iron, 2 sulfur cluster binding
K8O95_13045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K8O95_13050	COG0402	S-adenosylhomocysteine deaminase activity
K8O95_13055	COG0493	'glutamate synthase
K8O95_13055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O95_13060	COG2068	MobA-Related Protein
K8O95_13065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8O95_13070	COG3608	succinylglutamate desuccinylase aspartoacylase
K8O95_13070	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K8O95_13080	COG0697	spore germination
K8O95_13085	COG0549	Belongs to the carbamate kinase family
K8O95_13095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8O95_13100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K8O95_13105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K8O95_13115	COG0456	acetyltransferase
K8O95_13125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K8O95_13130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K8O95_13140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8O95_13145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K8O95_13155	COG0205	6-phosphofructokinase activity
K8O95_13165	COG1301	dicarboxylic acid transport
K8O95_13170	COG3123	guanosine phosphorylase activity
K8O95_13175	COG1760	l-serine dehydratase
K8O95_13180	COG1760	l-serine dehydratase
K8O95_13185	COG3100	YcgL domain-containing protein
K8O95_13190	COG0850	regulation of cytokinetic process
K8O95_13195	COG2894	cell division
K8O95_13200	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K8O95_13205	COG3099	Belongs to the UPF0263 family
K8O95_13210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8O95_13250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K8O95_13255	COG0697	spore germination
K8O95_13260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K8O95_13265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_13275	COG0307	riboflavin synthase, alpha
K8O95_13285	COG0534	Mate efflux family protein
K8O95_13315	COG3829	transcription factor binding
K8O95_13325	COG4681	YaeQ
K8O95_13335	COG2186	Transcriptional regulator
K8O95_13340	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8O95_13345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K8O95_13350	COG0586	Pfam SNARE associated Golgi protein
K8O95_13360	COG0556	nucleotide-excision repair
K8O95_13375	COG0569	domain protein
K8O95_13375	COG2985	domain, Protein
K8O95_13380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8O95_13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O95_13385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K8O95_13400	COG3069	C4-dicarboxylate transmembrane transporter activity
K8O95_13415	COG1451	nucleotide metabolic process
K8O95_13430	COG0417	DNA replication proofreading
K8O95_13445	COG1560	Kdo2-lipid A biosynthetic process
K8O95_13450	COG1560	Kdo2-lipid A biosynthetic process
K8O95_13465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K8O95_13470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K8O95_13480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8O95_13485	COG2832	Protein of unknown function (DUF454)
K8O95_13490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8O95_13500	COG1011	Hydrolase
K8O95_13505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O95_13550	COG3593	DNA synthesis involved in DNA repair
K8O95_13565	COG0583	DNA-binding transcription factor activity
K8O95_13570	COG0730	response to heat
K8O95_13575	COG3148	PFAM DTW domain containing protein
K8O95_13580	COG1940	carbohydrate kinase activity
K8O95_13580	COG1846	Transcriptional regulator
K8O95_13585	COG0840	transmembrane signaling receptor activity
K8O95_13590	COG3012	SEC-C Motif Domain Protein
K8O95_13595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K8O95_13600	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K8O95_13605	COG0247	lactate metabolic process
K8O95_13620	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K8O95_13625	COG0437	4 iron, 4 sulfur cluster binding
K8O95_13630	COG3301	Polysulphide reductase, NrfD
K8O95_13635	COG1138	Cytochrome C-type biogenesis protein
K8O95_13645	COG4235	cytochrome complex assembly
K8O95_13645	COG3088	subunit of a heme lyase
K8O95_13650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_13655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K8O95_13660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K8O95_13670	COG1840	ABC-type Fe3 transport system, periplasmic component
K8O95_13675	COG3842	ATPase activity
K8O95_13685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O95_13700	COG1446	asparaginase
K8O95_13720	COG0045	succinate-CoA ligase (ADP-forming) activity
K8O95_13725	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O95_13730	COG0567	Dehydrogenase, E1 component
K8O95_13740	COG1053	succinate dehydrogenase
K8O95_13745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K8O95_13750	COG2009	succinate dehydrogenase
K8O95_13770	COG0085	RNA polymerase activity
K8O95_13810	COG1175	transmembrane transport
K8O95_13815	COG0395	ABC-type sugar transport system, permease component
K8O95_13820	COG1554	hydrolase, family 65, central catalytic
K8O95_13825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O95_13830	COG3842	ATPase activity
K8O95_13840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K8O95_13855	COG2501	S4 domain
K8O95_13865	COG0583	DNA-binding transcription factor activity
K8O95_13875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_13885	COG1132	(ABC) transporter
K8O95_13890	COG1132	(ABC) transporter
K8O95_13900	COG3118	belongs to the thioredoxin family
K8O95_13905	COG0471	metal ion transport
K8O95_13915	COG0058	SHG alpha-glucan phosphorylase activity
K8O95_13930	COG2983	Belongs to the UPF0260 family
K8O95_13935	COG1882	Formate acetyltransferase
K8O95_13940	COG2116	formate transmembrane transporter activity
K8O95_13945	COG1944	ATP diphosphatase activity
K8O95_13950	COG2723	6-phospho-beta-galactosidase activity
K8O95_13955	COG0583	DNA-binding transcription factor activity
K8O95_13960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K8O95_13980	COG3708	Transcriptional regulator
K8O95_13980	COG2207	Transcriptional regulator
K8O95_14000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K8O95_14005	COG5001	Diguanylate cyclase
K8O95_14005	COG3300	MHYT domain
K8O95_14010	COG0583	DNA-binding transcription factor activity
K8O95_14015	COG3437	response regulator, receiver
K8O95_14040	COG4989	oxidoreductase activity
K8O95_14045	COG0724	RNA recognition motif
K8O95_14055	COG1126	abc transporter atp-binding protein
K8O95_14060	COG0765	amino acid transport
K8O95_14070	COG0765	amino acid transport
K8O95_14075	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K8O95_14085	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K8O95_14110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8O95_14115	COG1360	Flagellar Motor Protein
K8O95_14120	COG4771	TonB-dependent receptor
K8O95_14125	COG1770	oligopeptidase
K8O95_14145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_14150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_14155	COG0649	NAD binding
K8O95_14155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_14170	COG1034	ATP synthesis coupled electron transport
K8O95_14175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K8O95_14180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_14185	COG0839	Belongs to the complex I subunit 6 family
K8O95_14190	COG0713	ATP synthesis coupled electron transport
K8O95_14200	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O95_14205	COG1007	ATP synthesis coupled electron transport
K8O95_14215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K8O95_14220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K8O95_14220	COG2199	diguanylate cyclase activity
K8O95_14230	COG2050	protein possibly involved in aromatic compounds catabolism
K8O95_14240	COG0277	FAD linked oxidase domain protein
K8O95_14240	COG0247	lactate metabolic process
K8O95_14250	COG1253	flavin adenine dinucleotide binding
K8O95_14255	COG1902	pentaerythritol trinitrate reductase activity
K8O95_14265	COG0647	UMP catabolic process
K8O95_14270	COG4651	solute:proton antiporter activity
K8O95_14270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8O95_14280	COG0367	asparagine synthase
K8O95_14290	COG0625	glutathione transferase activity
K8O95_14300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K8O95_14315	COG0564	pseudouridine synthase activity
K8O95_14330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O95_14340	COG2431	L-lysine efflux transmembrane transporter activity
K8O95_14355	COG1393	Belongs to the ArsC family
K8O95_14365	COG4783	chaperone-mediated protein folding
K8O95_14370	COG0425	Belongs to the sulfur carrier protein TusA family
K8O95_14390	COG2326	polyphosphate kinase activity
K8O95_14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O95_14410	COG3842	ATPase activity
K8O95_14415	COG3833	ABC-type maltose transport systems, permease component
K8O95_14420	COG1175	transmembrane transport
K8O95_14430	COG3081	Nucleoid-associated protein
K8O95_14435	COG3082	Protein of unknown function (DUF1414)
K8O95_14440	COG3083	sulfuric ester hydrolase activity
K8O95_14445	COG1464	Belongs to the NlpA lipoprotein family
K8O95_14470	COG0574	Belongs to the PEP-utilizing enzyme family
K8O95_14470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O95_14475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K8O95_14485	COG1113	amino acid transport
K8O95_14495	COG3852	Histidine kinase
K8O95_14510	COG3119	arylsulfatase activity
K8O95_14515	COG0641	radical SAM
K8O95_14525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O95_14525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O95_14530	COG0509	glycine decarboxylation via glycine cleavage system
K8O95_14535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K8O95_14540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O95_14545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O95_14550	COG3079	Belongs to the UPF0149 family
K8O95_14555	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K8O95_14565	COG0642	Histidine kinase
K8O95_14595	COG3302	dmso reductase anchor subunit
K8O95_14600	COG0437	4 iron, 4 sulfur cluster binding
K8O95_14605	COG0243	molybdopterin cofactor binding
K8O95_14610	COG3381	protein complex oligomerization
K8O95_14665	COG3118	belongs to the thioredoxin family
K8O95_14670	COG0492	ferredoxin-NADP+ reductase activity
K8O95_14675	COG1115	amino acid carrier protein
K8O95_14680	COG1063	alcohol dehydrogenase
K8O95_14700	COG4974	Belongs to the 'phage' integrase family
K8O95_14830	COG1328	CTP reductase activity
K8O95_14835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8O95_14840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K8O95_14940	COG0322	excinuclease ABC activity
K8O95_14945	COG2197	response regulator
K8O95_14950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K8O95_14955	COG2835	tetraacyldisaccharide 4'-kinase activity
K8O95_14960	COG1663	tetraacyldisaccharide 4'-kinase activity
K8O95_14965	COG1132	(ABC) transporter
K8O95_14970	COG2333	competence protein COMEC
K8O95_14970	COG0658	competence protein
K8O95_14985	COG0433	COG0433 Predicted ATPase
K8O95_14990	COG1448	Aminotransferase
K8O95_15000	COG0583	DNA-binding transcription factor activity
K8O95_15005	COG3085	chromosome segregation
K8O95_15010	COG4574	serine-type endopeptidase inhibitor activity
K8O95_15015	COG0584	glycerophosphoryl diester phosphodiesterase
K8O95_15025	COG1349	DNA-binding transcription factor activity
K8O95_15030	COG2271	Major facilitator Superfamily
K8O95_15035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K8O95_15040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K8O95_15045	COG0583	DNA-binding transcription factor activity
K8O95_15075	COG0656	L-ascorbic acid biosynthetic process
K8O95_15085	COG2814	Major facilitator Superfamily
K8O95_15095	COG2979	Protein of unknown function (DUF533)
K8O95_15120	COG1187	pseudouridine synthase activity
K8O95_15125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8O95_15160	COG4657	Part of a membrane complex involved in electron transport
K8O95_15165	COG2878	Part of a membrane complex involved in electron transport
K8O95_15175	COG4658	electron transport chain
K8O95_15180	COG4659	FMN binding
K8O95_15185	COG4660	Part of a membrane complex involved in electron transport
K8O95_15190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K8O95_15195	COG0346	lactoylglutathione lyase activity
K8O95_15225	COG3340	Belongs to the peptidase S51 family
K8O95_15240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8O95_15245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8O95_15250	COG0505	Belongs to the CarA family
K8O95_15255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K8O95_15265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K8O95_15270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K8O95_15275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8O95_15280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K8O95_15285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K8O95_15290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K8O95_15315	COG2020	methyltransferase activity
K8O95_15320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8O95_15325	COG0861	Integral membrane protein TerC family
K8O95_15340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8O95_15345	COG0601	transmembrane transport
K8O95_15355	COG2095	MarC family integral membrane protein
K8O95_15360	COG1012	belongs to the aldehyde dehydrogenase family
K8O95_15360	COG1454	alcohol dehydrogenase
K8O95_15365	COG0217	transcriptional regulatory protein
K8O95_15370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K8O95_15380	COG1801	Protein of unknown function DUF72
K8O95_15385	COG4106	trans-aconitate 2-methyltransferase activity
K8O95_15390	COG0500	methyltransferase
K8O95_15410	COG0450	alkyl hydroperoxide reductase
K8O95_15415	COG0583	DNA-binding transcription factor activity
K8O95_15420	COG0791	NLP P60 protein
K8O95_15430	COG0659	secondary active sulfate transmembrane transporter activity
K8O95_15435	COG0538	isocitrate dehydrogenase activity
K8O95_15440	COG2207	Transcriptional regulator
K8O95_15445	COG1482	cell wall glycoprotein biosynthetic process
K8O95_15450	COG3537	Alpha-1,2-mannosidase
K8O95_15470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O95_15485	COG4521	taurine ABC transporter
K8O95_15490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K8O95_15495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8O95_15500	COG2175	clavaminate synthase activity
K8O95_15505	COG3152	Membrane
K8O95_15530	COG1309	transcriptional regulator
K8O95_15540	COG1454	alcohol dehydrogenase
K8O95_15560	COG0534	Mate efflux family protein
K8O95_15570	COG2841	Protein conserved in bacteria
K8O95_15575	COG1653	transport
K8O95_15580	COG5002	protein histidine kinase activity
K8O95_15580	COG5001	Diguanylate cyclase
K8O95_15585	COG3132	Protein of unknown function, DUF480
K8O95_15620	COG0708	Exodeoxyribonuclease III
K8O95_15640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O95_15645	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_15655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8O95_15660	COG1120	ATPase activity
K8O95_15665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8O95_15670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8O95_15675	COG4771	TonB-dependent receptor
K8O95_15680	COG2375	cellular response to nickel ion
K8O95_15685	COG0784	Response regulator, receiver
K8O95_15685	COG3437	response regulator, receiver
K8O95_15695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K8O95_15700	COG0328	RNA-DNA hybrid ribonuclease activity
K8O95_15705	COG2226	methyltransferase
K8O95_15710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O95_15715	COG0741	lytic transglycosylase activity
K8O95_15715	COG1388	LysM domain
K8O95_15735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8O95_15755	COG4104	PAAR repeat-containing protein
K8O95_15775	COG1073	alpha beta
K8O95_15780	COG1506	peptidase
K8O95_15780	COG0823	Involved in the tonB-independent uptake of proteins
K8O95_15785	COG0702	epimerase
K8O95_15800	COG1376	ErfK ybiS ycfS ynhG family protein
K8O95_15800	COG1388	LysM domain
K8O95_15810	COG0471	metal ion transport
K8O95_15820	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K8O95_15825	COG0791	NLP P60 protein
K8O95_15845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8O95_15850	COG0788	formyltetrahydrofolate deformylase activity
K8O95_15860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O95_15875	COG0739	heme binding
K8O95_15875	COG0741	lytic transglycosylase activity
K8O95_15875	COG1196	nuclear chromosome segregation
K8O95_15890	COG0436	Aminotransferase
K8O95_15895	COG3264	Mechanosensitive ion channel
K8O95_15895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K8O95_15900	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8O95_15910	COG2205	protein histidine kinase activity
K8O95_15915	COG0745	RESPONSE REGULATOR receiver
K8O95_15925	COG3681	Belongs to the UPF0597 family
K8O95_15930	COG0251	oxidation-reduction process
K8O95_15935	COG0814	amino acid
K8O95_15950	COG0583	DNA-binding transcription factor activity
K8O95_15955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K8O95_15965	COG1166	arginine decarboxylase activity
K8O95_15970	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8O95_15985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K8O95_15995	COG2353	YceI-like domain
K8O95_16000	COG0583	DNA-binding transcription factor activity
K8O95_16010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K8O95_16015	COG0840	transmembrane signaling receptor activity
K8O95_16020	COG0302	gtp cyclohydrolase
K8O95_16030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8O95_16045	COG2267	carboxylic ester hydrolase activity
K8O95_16050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K8O95_16065	COG0314	molybdopterin synthase activity
K8O95_16070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K8O95_16075	COG0315	cyclic pyranopterin monophosphate synthase activity
K8O95_16080	COG0521	Mo-molybdopterin cofactor biosynthetic process
K8O95_16085	COG3005	denitrification pathway
K8O95_16095	COG0348	domain, Protein
K8O95_16100	COG0437	4 iron, 4 sulfur cluster binding
K8O95_16105	COG0243	molybdopterin cofactor binding
K8O95_16115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O95_16120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8O95_16125	COG3850	Histidine kinase
K8O95_16130	COG2197	response regulator
K8O95_16160	COG0121	glutamine amidotransferase
K8O95_16165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K8O95_16170	COG1960	acyl-CoA dehydrogenase activity
K8O95_16175	COG1473	amidohydrolase
K8O95_16180	COG2914	Belongs to the UPF0125 (RnfH) family
K8O95_16185	COG2867	negative regulation of translational initiation
K8O95_16190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K8O95_16200	COG1349	DNA-binding transcription factor activity
K8O95_16205	COG0738	Major facilitator superfamily
K8O95_16230	COG1454	alcohol dehydrogenase
K8O95_16235	COG3383	formate dehydrogenase (NAD+) activity
K8O95_16245	COG4821	SIS domain
K8O95_16250	COG4821	SIS domain
K8O95_16255	COG3716	PTS system mannose fructose sorbose family IID component
K8O95_16260	COG3715	PTS system
K8O95_16265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_16275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K8O95_16280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_16285	COG2222	sugar isomerase
K8O95_16295	COG1349	DNA-binding transcription factor activity
K8O95_16300	COG2017	converts alpha-aldose to the beta-anomer
K8O95_16305	COG2814	Major facilitator Superfamily
K8O95_16305	COG0477	Major facilitator Superfamily
K8O95_16310	COG0457	Tetratricopeptide repeat
K8O95_16315	COG1940	carbohydrate kinase activity
K8O95_16325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K8O95_16335	COG1960	acyl-CoA dehydrogenase activity
K8O95_16340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_16350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K8O95_16355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8O95_16360	COG1263	PTS System
K8O95_16360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_16365	COG1609	Transcriptional regulator
K8O95_16385	COG1309	transcriptional regulator
K8O95_16390	COG2130	NADP-dependent
K8O95_16395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K8O95_16415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K8O95_16420	COG0083	homoserine kinase activity
K8O95_16430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K8O95_16435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K8O95_16440	COG1946	Acyl-CoA thioesterase
K8O95_16455	COG3210	domain, Protein
K8O95_16480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K8O95_16490	COG0009	L-threonylcarbamoyladenylate synthase
K8O95_16500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8O95_16505	COG0512	Glutamine amidotransferase of anthranilate synthase
K8O95_16505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8O95_16510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8O95_16515	COG0134	indole-3-glycerol-phosphate synthase activity
K8O95_16515	COG0135	phosphoribosylanthranilate isomerase activity
K8O95_16520	COG0133	tryptophan synthase activity
K8O95_16525	COG0159	tryptophan synthase activity
K8O95_16535	COG0515	serine threonine protein kinase
K8O95_16535	COG2815	serine threonine protein kinase
K8O95_16545	COG1988	membrane-bound metal-dependent
K8O95_16565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8O95_16575	COG0798	PFAM Bile acid sodium symporter
K8O95_16590	COG0640	Transcriptional regulator
K8O95_16605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K8O95_16615	COG0745	RESPONSE REGULATOR receiver
K8O95_16630	COG4988	ABC transporter
K8O95_16635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K8O95_16655	COG1720	tRNA m6t6A37 methyltransferase activity
K8O95_16660	COG3038	cytochrome b561
K8O95_16680	COG2862	Uncharacterized protein family, UPF0114
K8O95_16730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O95_16735	COG1396	sequence-specific DNA binding
K8O95_16735	COG1917	Cupin 2, conserved barrel domain protein
K8O95_16740	COG1012	belongs to the aldehyde dehydrogenase family
K8O95_16750	COG0531	amino acid
K8O95_16755	COG0531	amino acid
K8O95_16770	COG1283	sodium-dependent phosphate transmembrane transporter activity
K8O95_16785	COG2974	May be involved in recombination
K8O95_16795	COG0420	3'-5' exonuclease activity
K8O95_16800	COG0419	ATPase involved in DNA repair
K8O95_16805	COG3384	dioxygenase
K8O95_16815	COG0469	pyruvate kinase activity
K8O95_16820	COG1196	nuclear chromosome segregation
K8O95_16820	COG3264	Mechanosensitive ion channel
K8O95_16825	COG2190	(PTS) system
K8O95_16830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O95_16835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_16840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8O95_16845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8O95_16860	COG2770	Histidine kinase
K8O95_16860	COG3437	response regulator, receiver
K8O95_16865	COG3409	Peptidoglycan-binding domain 1 protein
K8O95_16865	COG3267	Type II secretory pathway component ExeA
K8O95_16875	COG3031	protein transport across the cell outer membrane
K8O95_16880	COG1450	Type ii and iii secretion system protein
K8O95_16885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8O95_16890	COG1459	type II secretion system
K8O95_16895	COG2165	general secretion pathway protein
K8O95_16905	COG2165	general secretion pathway protein
K8O95_16910	COG4795	General secretion pathway protein
K8O95_16915	COG3156	type II secretion system protein K
K8O95_16925	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K8O95_16935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8O95_16940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8O95_16945	COG2723	6-phospho-beta-galactosidase activity
K8O95_16950	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8O95_16955	COG1917	Cupin 2, conserved barrel domain protein
K8O95_16955	COG2169	Transcriptional regulator
K8O95_16960	COG1486	melibiose metabolic process
K8O95_16980	COG0670	Belongs to the BI1 family
K8O95_16985	COG1289	transmembrane transporter activity
K8O95_16990	COG2920	part of a sulfur-relay system
K8O95_17000	COG0673	inositol 2-dehydrogenase activity
K8O95_17030	COG1032	radical SAM domain protein
K8O95_17035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O95_17040	COG1566	PFAM secretion protein HlyD family protein
K8O95_17050	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8O95_17055	COG0733	neurotransmitter:sodium symporter activity
K8O95_17085	COG0281	malic enzyme
K8O95_17095	COG0534	Mate efflux family protein
K8O95_17105	COG3706	GGDEF domain
K8O95_17110	COG2233	PERMEase
K8O95_17115	COG0095	Lipoate-protein ligase
K8O95_17120	COG1115	amino acid carrier protein
K8O95_17125	COG0019	diaminopimelate decarboxylase activity
K8O95_17135	COG0678	peroxiredoxin activity
K8O95_17145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K8O95_17160	COG0545	Peptidyl-prolyl cis-trans isomerase
K8O95_17165	COG3142	Participates in the control of copper homeostasis
K8O95_17190	COG5002	protein histidine kinase activity
K8O95_17195	COG0745	RESPONSE REGULATOR receiver
K8O95_17200	COG0346	lactoylglutathione lyase activity
K8O95_17205	COG3706	GGDEF domain
K8O95_17210	COG3284	Transcriptional regulator
K8O95_17225	COG0697	spore germination
K8O95_17235	COG3290	protein histidine kinase activity
K8O95_17250	COG1566	PFAM secretion protein HlyD family protein
K8O95_17275	COG0602	queuosine metabolic process
K8O95_17280	COG1328	CTP reductase activity
K8O95_17290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8O95_17295	COG3115	cell septum assembly
K8O95_17300	COG1196	nuclear chromosome segregation
K8O95_17310	COG2860	membrane
K8O95_17320	COG3108	Peptidase M15
K8O95_17325	COG2989	Protein conserved in bacteria
K8O95_17340	COG0463	Glycosyl transferase, family 2
K8O95_17355	COG0366	Alpha amylase catalytic
K8O95_17390	COG2203	Gaf domain
K8O95_17390	COG2199	diguanylate cyclase activity
K8O95_17400	COG3590	peptidase
K8O95_17410	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K8O95_17415	COG1982	Orn Lys Arg decarboxylase major
K8O95_17420	COG0531	amino acid
K8O95_17425	COG3710	Transcriptional regulator
K8O95_17430	COG0531	amino acid
K8O95_17435	COG0814	amino acid
K8O95_17450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8O95_17455	COG0739	heme binding
K8O95_17460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K8O95_17480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K8O95_17490	COG3091	SprT-like family
K8O95_17500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K8O95_17505	COG0189	ligase activity
K8O95_17515	COG1678	Uncharacterized ACR, COG1678
K8O95_17520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K8O95_17530	COG0714	Associated with various cellular activities
K8O95_17545	COG1115	amino acid carrier protein
K8O95_17550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8O95_17560	COG0825	malonyl-CoA metabolic process
K8O95_17570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K8O95_17575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O95_17580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O95_17585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O95_17590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O95_17605	COG0750	zinc metalloprotease
K8O95_17610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K8O95_17615	COG0575	Belongs to the CDS family
K8O95_17620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K8O95_17625	COG0233	cytoplasmic translational termination
K8O95_17630	COG0528	UMP kinase activity
K8O95_17635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K8O95_17640	COG0052	Belongs to the universal ribosomal protein uS2 family
K8O95_17645	COG0024	Methionine aminopeptidase
K8O95_17655	COG2171	N-acyltransferase activity
K8O95_17665	COG1263	PTS System
K8O95_17665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_17680	COG0716	FMN binding
K8O95_17685	COG0564	pseudouridine synthase activity
K8O95_17690	COG3098	single-species biofilm formation
K8O95_17715	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K8O95_17725	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K8O95_17725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K8O95_17740	COG1611	Belongs to the LOG family
K8O95_17745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O95_17750	COG0473	3-isopropylmalate dehydrogenase activity
K8O95_17760	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K8O95_17765	COG2363	Small membrane protein
K8O95_17775	COG0583	DNA-binding transcription factor activity
K8O95_17780	COG0840	transmembrane signaling receptor activity
K8O95_17785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K8O95_17800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8O95_17805	COG1666	GTP binding
K8O95_17810	COG3248	Nucleoside-binding outer membrane protein
K8O95_17815	COG2211	Major facilitator Superfamily
K8O95_17820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K8O95_17830	COG2813	Specifically methylates the guanine in position
K8O95_17835	COG0271	Belongs to the BolA IbaG family
K8O95_17840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8O95_17845	COG1805	sodium ion transport
K8O95_17850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8O95_17855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8O95_17860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8O95_17865	COG2871	sodium ion transport
K8O95_17870	COG1477	protein flavinylation
K8O95_17900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K8O95_17915	COG0300	oxidoreductase activity
K8O95_17925	COG0415	Belongs to the DNA photolyase family
K8O95_17930	COG0789	Transcriptional regulator
K8O95_17935	COG3272	Protein of unknown function (DUF1722)
K8O95_17965	COG0077	Prephenate dehydratase
K8O95_17965	COG1605	Chorismate mutase
K8O95_17995	COG1335	isochorismatase
K8O95_18000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K8O95_18005	COG1304	FMN binding
K8O95_18010	COG0549	Belongs to the carbamate kinase family
K8O95_18025	COG0583	DNA-binding transcription factor activity
K8O95_18035	COG0840	transmembrane signaling receptor activity
K8O95_18045	COG0300	oxidoreductase activity
K8O95_18070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K8O95_18110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8O95_18120	COG0826	peptidase U32
K8O95_18125	COG1280	lysine exporter protein (LysE YggA)
K8O95_18135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O95_18155	COG2198	Histidine kinase
K8O95_18155	COG0643	Histidine kinase
K8O95_18160	COG0835	chemotaxis
K8O95_18165	COG3290	protein histidine kinase activity
K8O95_18165	COG0840	transmembrane signaling receptor activity
K8O95_18170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8O95_18175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K8O95_18180	COG2201	protein-glutamate methylesterase activity
K8O95_18185	COG1185	polyribonucleotide nucleotidyltransferase activity
K8O95_18190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K8O95_18195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K8O95_18200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K8O95_18205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K8O95_18210	COG0195	Participates in both transcription termination and antitermination
K8O95_18215	COG0779	Required for maturation of 30S ribosomal subunits
K8O95_18230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8O95_18235	COG0149	triose-phosphate isomerase activity
K8O95_18240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8O95_18245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K8O95_18255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K8O95_18260	COG1534	Rna-binding protein
K8O95_18275	COG1360	Flagellar Motor Protein
K8O95_18275	COG1360	Flagellar Motor Protein
K8O95_18280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8O95_18285	COG1722	exodeoxyribonuclease VII activity
K8O95_18290	COG0142	geranyltranstransferase activity
K8O95_18295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K8O95_18305	COG0601	transmembrane transport
K8O95_18315	COG4172	Belongs to the ABC transporter superfamily
K8O95_18320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K8O95_18325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K8O95_18330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O95_18350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O95_18350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O95_18355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K8O95_18365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K8O95_18370	COG0784	Response regulator, receiver
K8O95_18370	COG2198	Histidine kinase
K8O95_18370	COG2205	protein histidine kinase activity
K8O95_18375	COG1879	ABC-type sugar transport system periplasmic component
K8O95_18385	COG0745	RESPONSE REGULATOR receiver
K8O95_18390	COG3005	denitrification pathway
K8O95_18400	COG3381	protein complex oligomerization
K8O95_18415	COG5001	Diguanylate cyclase
K8O95_18415	COG3300	MHYT domain
K8O95_18420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8O95_18425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K8O95_18430	COG0511	ligase activity, forming carbon-carbon bonds
K8O95_18435	COG0439	Biotin carboxylase
K8O95_18445	COG4145	pantothenate transmembrane transporter activity
K8O95_18450	COG1263	PTS System
K8O95_18450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_18450	COG2190	(PTS) system
K8O95_18455	COG0583	DNA-binding transcription factor activity
K8O95_18460	COG0604	alcohol dehydrogenase
K8O95_18465	COG2264	protein methyltransferase activity
K8O95_18470	COG0778	Nitroreductase
K8O95_18475	COG1902	pentaerythritol trinitrate reductase activity
K8O95_18475	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8O95_18480	COG0616	signal peptide processing
K8O95_18500	COG0848	biopolymer transport protein
K8O95_18505	COG0811	peptide transport
K8O95_18510	COG0811	peptide transport
K8O95_18525	COG4174	ABC transporter (Permease)
K8O95_18530	COG4239	(ABC) transporter, permease
K8O95_18540	COG0444	Belongs to the ABC transporter superfamily
K8O95_18545	COG4608	Belongs to the ABC transporter superfamily
K8O95_18565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K8O95_18575	COG0463	Glycosyl transferase, family 2
K8O95_18580	COG0741	lytic transglycosylase activity
K8O95_18585	COG0488	(ABC) transporter
K8O95_18595	COG2252	PERMEase
K8O95_18605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K8O95_18610	COG2982	Protein involved in outer membrane biogenesis
K8O95_18640	COG2070	2-Nitropropane dioxygenase
K8O95_18660	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
K8O95_18670	COG2203	Gaf domain
K8O95_18670	COG2199	diguanylate cyclase activity
K8O95_18675	COG0513	Belongs to the DEAD box helicase family
K8O95_18695	COG2957	Belongs to the agmatine deiminase family
K8O95_18710	COG1902	pentaerythritol trinitrate reductase activity
K8O95_18720	COG4942	peptidase
K8O95_18720	COG1388	LysM domain
K8O95_18725	COG1238	metal cluster binding
K8O95_18730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K8O95_18735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K8O95_18740	COG0585	pseudouridine synthase activity
K8O95_18750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K8O95_18755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K8O95_18760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8O95_18770	COG0668	transmembrane transport
K8O95_18780	COG2731	YhcH YjgK YiaL family protein
K8O95_18790	COG2132	Multicopper oxidase
K8O95_18795	COG1794	racemase activity, acting on amino acids and derivatives
K8O95_18810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8O95_18820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K8O95_18820	COG0517	IMP dehydrogenase activity
K8O95_18840	COG0488	(ABC) transporter
K8O95_18850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K8O95_18900	COG1335	isochorismatase
K8O95_18915	COG0148	phosphopyruvate hydratase activity
K8O95_18920	COG0504	CTP synthase activity
K8O95_18925	COG3956	TIGRFAM MazG family protein
K8O95_18930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8O95_18935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8O95_18945	COG4807	Protein conserved in bacteria
K8O95_18950	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8O95_18955	COG0783	Belongs to the Dps family
K8O95_18960	COG1151	hydroxylamine reductase activity
K8O95_18965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8O95_18970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8O95_18975	COG0671	phosphoesterase, PA-phosphatase related
K8O95_18980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8O95_18985	COG0163	prenyltransferase activity
K8O95_19000	COG1131	(ABC) transporter
K8O95_19005	COG0842	Transport permease protein
K8O95_19020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K8O95_19025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K8O95_19040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O95_19045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8O95_19050	COG1489	DNA binding
K8O95_19055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K8O95_19060	COG1643	Atp-dependent helicase
K8O95_19065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8O95_19070	COG0346	lactoylglutathione lyase activity
K8O95_19075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K8O95_19090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K8O95_19105	COG1136	(ABC) transporter
K8O95_19135	COG0529	Catalyzes the synthesis of activated sulfate
K8O95_19140	COG3273	potassium ion transport
K8O95_19140	COG0471	metal ion transport
K8O95_19145	COG2895	sulfate adenylyltransferase (ATP) activity
K8O95_19150	COG0175	sulfate reduction
K8O95_19155	COG1648	precorrin-2 dehydrogenase activity
K8O95_19155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8O95_19160	COG0330	HflC and HflK could
K8O95_19165	COG1585	Membrane protein implicated in regulation of membrane protease activity
K8O95_19170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K8O95_19180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8O95_19185	COG1640	4-alpha-glucanotransferase
K8O95_19190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K8O95_19210	COG0494	nUDIX hydrolase
K8O95_19225	COG0138	bifunctional purine biosynthesis protein purh
K8O95_19235	COG3036	rescue of stalled ribosome
K8O95_19240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8O95_19245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K8O95_19255	COG0673	inositol 2-dehydrogenase activity
K8O95_19265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8O95_19270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8O95_19275	COG0583	DNA-binding transcription factor activity
K8O95_19280	COG0477	Major facilitator Superfamily
K8O95_19285	COG0456	acetyltransferase
K8O95_19310	COG3300	MHYT domain
K8O95_19310	COG5001	Diguanylate cyclase
K8O95_19315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K8O95_19320	COG0714	Associated with various cellular activities
K8O95_19335	COG0456	acetyltransferase
K8O95_19345	COG1022	Amp-dependent synthetase and ligase
K8O95_19355	COG2918	glutathione biosynthetic process
K8O95_19360	COG0612	Peptidase, M16
K8O95_19365	COG1238	metal cluster binding
K8O95_19370	COG1064	alcohol dehydrogenase
K8O95_19400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8O95_19405	COG0359	binds to the 23S rRNA
K8O95_19410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K8O95_19415	COG0360	Binds together with S18 to 16S ribosomal RNA
K8O95_19420	COG1914	H( )-stimulated, divalent metal cation uptake system
K8O95_19425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8O95_19430	COG0776	regulation of translation
K8O95_19460	COG0560	Phosphoserine phosphatase
K8O95_19470	COG5002	protein histidine kinase activity
K8O95_19470	COG5001	Diguanylate cyclase
K8O95_19470	COG3447	MASE1 domain protein
K8O95_19475	COG0813	purine-nucleoside phosphorylase activity
K8O95_19480	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K8O95_19485	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K8O95_19490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K8O95_19500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8O95_19505	COG0084	hydrolase, TatD family'
K8O95_19510	COG2165	general secretion pathway protein
K8O95_19520	COG1854	S-ribosylhomocysteine lyase activity
K8O95_19535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8O95_19535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K8O95_19595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K8O95_19600	COG1047	Peptidyl-prolyl cis-trans
K8O95_19605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K8O95_19610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K8O95_19615	COG0196	riboflavin kinase activity
K8O95_19620	COG0728	peptidoglycan biosynthetic process
K8O95_19625	COG0268	Binds directly to 16S ribosomal RNA
K8O95_19630	COG0640	Transcriptional regulator
K8O95_19635	COG0583	DNA-binding transcription factor activity
K8O95_19645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8O95_19650	COG3068	Protein conserved in bacteria
K8O95_19660	COG0739	heme binding
K8O95_19680	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K8O95_19685	COG1121	(ABC) transporter
K8O95_19690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8O95_19695	COG0583	DNA-binding transcription factor activity
K8O95_19700	COG0697	spore germination
K8O95_19705	COG1573	uracil-dna glycosylase
K8O95_19720	COG2827	Endonuclease containing a URI domain
K8O95_19735	COG1842	Phage shock protein A
K8O95_19740	COG0204	Acyl-transferase
K8O95_19760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O95_19790	COG0814	amino acid
K8O95_19830	COG2329	Antibiotic biosynthesis monooxygenase
K8O95_19835	COG0187	DNA topoisomerase II activity
K8O95_19840	COG1051	belongs to the nudix hydrolase family
K8O95_19845	COG3150	esterase
K8O95_19855	COG3151	Protein conserved in bacteria
K8O95_19860	COG0494	nUDIX hydrolase
K8O95_19865	COG1538	Outer membrane efflux protein
K8O95_19870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K8O95_19870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K8O95_19875	COG1560	Kdo2-lipid A biosynthetic process
K8O95_19880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O95_19880	COG2213	PTS system mannitol-specific
K8O95_19885	COG0246	Mannitol dehydrogenase
K8O95_19890	COG3722	fumarate hydratase activity
K8O95_19900	COG0484	heat shock protein binding
K8O95_19920	COG1671	Belongs to the UPF0178 family
K8O95_19935	COG1988	membrane-bound metal-dependent
K8O95_19940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8O95_19945	COG0513	Belongs to the DEAD box helicase family
K8O95_19970	COG1575	Belongs to the MenA family. Type 1 subfamily
K8O95_19975	COG1169	isochorismate synthase
K8O95_19980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K8O95_19985	COG0596	Alpha beta hydrolase
K8O95_19990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K8O95_19995	COG1441	menaquinone biosynthetic process
K8O95_20005	COG3291	Pkd domain containing protein
K8O95_20015	COG1444	tRNA N-acetyltransferase activity
K8O95_20035	COG1803	Methylglyoxal synthase
K8O95_20040	COG1979	alcohol dehydrogenase
K8O95_20055	COG4221	oxidoreductase activity
K8O95_20085	COG1368	sulfuric ester hydrolase activity
K8O95_20090	COG1522	sequence-specific DNA binding
K8O95_20100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K8O95_20105	COG1418	mRNA catabolic process
K8O95_20110	COG1058	Belongs to the CinA family
K8O95_20110	COG1546	Belongs to the CinA family
K8O95_20120	COG0561	phosphatase activity
K8O95_20130	COG2926	Belongs to the UPF0265 family
K8O95_20165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8O95_20170	COG0564	pseudouridine synthase activity
K8O95_20180	COG0110	maltose O-acetyltransferase activity
K8O95_20185	COG0366	Alpha amylase catalytic
K8O95_20190	COG1263	PTS System
K8O95_20190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O95_20210	COG0252	asparaginase activity
K8O95_20215	COG1253	flavin adenine dinucleotide binding
K8O95_20220	COG0586	Pfam SNARE associated Golgi protein
K8O95_20225	COG1686	Belongs to the peptidase S11 family
K8O95_20250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K8O95_20255	COG0527	aspartate kinase activity
K8O95_20260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8O95_20270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K8O95_20275	COG1546	Belongs to the CinA family
K8O95_20280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8O95_20290	COG1346	cytolysis
K8O95_20295	COG1380	Effector of murein hydrolase LrgA
K8O95_20300	COG0583	DNA-binding transcription factor activity
K8O95_20310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8O95_20315	COG0406	alpha-ribazole phosphatase activity
K8O95_20320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K8O95_20330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K8O95_20335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily